locus-tag	class	description
HF295_00010	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HF295_00020	COG3457	Alanine racemase
HF295_00030	COG5012	cobalamin binding
HF295_00040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HF295_00050	COG3804	dihydrodipicolinate reductase
HF295_00055	COG0549	Belongs to the carbamate kinase family
HF295_00060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HF295_00070	COG0116	Belongs to the methyltransferase superfamily
HF295_00085	COG1342	Belongs to the UPF0251 family
HF295_00095	COG0450	alkyl hydroperoxide reductase
HF295_00110	COG0336	Belongs to the RNA methyltransferase TrmD family
HF295_00115	COG0335	large ribosomal subunit rRNA binding
HF295_00130	COG1253	flavin adenine dinucleotide binding
HF295_00135	COG2217	Heavy metal translocating P-type atpase
HF295_00140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HF295_00145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HF295_00150	COG1363	Peptidase, m42
HF295_00160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HF295_00170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HF295_00175	COG0237	dephospho-CoA kinase activity
HF295_00180	COG3611	Membrane attachment protein
HF295_00185	COG1484	DNA-dependent DNA replication
HF295_00190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HF295_00200	COG0194	GDP metabolic process
HF295_00205	COG1758	RNA polymerase activity
HF295_00210	COG2176	DNA-directed DNA polymerase activity
HF295_00230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HF295_00240	COG1592	Rubrerythrin
HF295_00245	COG1162	GTPase activity
HF295_00250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HF295_00260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HF295_00265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HF295_00270	COG0251	oxidation-reduction process
HF295_00280	COG1461	Dihydroxyacetone kinase
HF295_00285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HF295_00290	COG0416	fatty acid biosynthetic process
HF295_00305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HF295_00315	COG0489	protein tyrosine kinase activity
HF295_00330	COG0275	rRNA processing
HF295_00500	COG1595	DNA-templated transcription, initiation
HF295_00510	COG2801	Transposase and inactivated derivatives
HF295_00515	COG1373	ATPase (AAA superfamily
HF295_00530	COG0668	transmembrane transport
HF295_00535	COG1136	(ABC) transporter
HF295_00540	COG4591	ABC-type transport system involved in lipoprotein release permease component
HF295_00550	COG0017	Asparaginyl-tRNA synthetase
HF295_00555	COG0564	pseudouridine synthase activity
HF295_00560	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HF295_00565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HF295_00580	COG1307	EDD domain protein, DegV family
HF295_00585	COG1132	(ABC) transporter
HF295_00590	COG1132	(ABC) transporter
HF295_00605	COG1132	(ABC) transporter
HF295_00610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF295_00620	COG1473	amidohydrolase
HF295_00650	COG0180	Tryptophanyl-tRNA synthetase
HF295_00660	COG1393	Belongs to the ArsC family
HF295_00675	COG0006	proline dipeptidase activity
HF295_00680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HF295_00685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HF295_00690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HF295_00695	COG3906	Belongs to the UPF0473 family
HF295_00700	COG4122	O-methyltransferase activity
HF295_00715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HF295_00720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HF295_00730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HF295_00735	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HF295_00740	COG1713	HD superfamily hydrolase involved in NAD metabolism
HF295_00745	COG0799	negative regulation of ribosome biogenesis
HF295_00750	COG2226	methyltransferase
HF295_00755	COG1596	polysaccharide export
HF295_00755	COG1555	photosystem II stabilization
HF295_00760	COG0658	competence protein
HF295_00760	COG2333	competence protein COMEC
HF295_00770	COG0268	Binds directly to 16S ribosomal RNA
HF295_00780	COG0469	pyruvate kinase activity
HF295_00800	COG0488	(ABC) transporter
HF295_00805	COG0018	arginyl-trna synthetase
HF295_00810	COG1132	(ABC) transporter
HF295_00815	COG1132	(ABC) transporter
HF295_00820	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HF295_00830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HF295_00845	COG2832	Protein of unknown function (DUF454)
HF295_00850	COG0492	ferredoxin-NADP+ reductase activity
HF295_00860	COG1012	belongs to the aldehyde dehydrogenase family
HF295_00900	COG0318	PFAM AMP-dependent synthetase and ligase
HF295_00915	COG0746	molybdenum cofactor guanylyltransferase activity
HF295_00930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HF295_00930	COG2080	2 iron, 2 sulfur cluster binding
HF295_00940	COG3608	succinylglutamate desuccinylase aspartoacylase
HF295_00940	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HF295_00950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HF295_00955	COG0402	S-adenosylhomocysteine deaminase activity
HF295_00960	COG0167	dihydroorotate dehydrogenase activity
HF295_00980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HF295_00990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HF295_00995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HF295_01000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HF295_01010	COG0590	tRNA wobble adenosine to inosine editing
HF295_01025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HF295_01030	COG0509	glycine decarboxylation via glycine cleavage system
HF295_01035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF295_01040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF295_01055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HF295_01060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HF295_01065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HF295_01080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HF295_01085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HF295_01100	COG0656	L-ascorbic acid biosynthetic process
HF295_01115	COG5297	Belongs to the glycosyl hydrolase family 6
HF295_01115	COG3250	beta-galactosidase activity
HF295_01130	COG1175	transmembrane transport
HF295_01135	COG0395	ABC-type sugar transport system, permease component
HF295_01155	COG0395	ABC-type sugar transport system, permease component
HF295_01165	COG1609	Transcriptional regulator
HF295_01180	COG2508	Transcriptional regulator
HF295_01185	COG3842	ATPase activity
HF295_01210	COG0673	inositol 2-dehydrogenase activity
HF295_01225	COG1129	ABC transporter
HF295_01230	COG1172	Belongs to the binding-protein-dependent transport system permease family
HF295_01235	COG1420	regulation of RNA biosynthetic process
HF295_01240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF295_01245	COG0443	Heat shock 70 kDa protein
HF295_01280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF295_01290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HF295_01295	COG1702	phosphate starvation-inducible protein PhoH
HF295_01300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HF295_01305	COG0295	cytidine deaminase activity
HF295_01310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HF295_01320	COG0423	glycine-tRNA ligase activity
HF295_01325	COG0358	DNA primase activity
HF295_01330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HF295_01335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HF295_01350	COG1307	EDD domain protein, DegV family
HF295_01355	COG1846	Transcriptional regulator
HF295_01365	COG3763	UPF0154 protein
HF295_01375	COG0187	DNA topoisomerase II activity
HF295_01380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HF295_01395	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HF295_01395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HF295_01400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HF295_01405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HF295_01410	COG1490	D-aminoacyl-tRNA deacylase activity
HF295_01420	COG0124	histidyl-tRNA synthetase
HF295_01425	COG0628	permease
HF295_01435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HF295_01450	COG3480	Lon protease (S16) C-terminal proteolytic domain
HF295_01475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HF295_01480	COG0564	pseudouridine synthase activity
HF295_01485	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HF295_01490	COG1193	negative regulation of DNA recombination
HF295_01495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HF295_01500	COG0196	riboflavin kinase activity
HF295_01510	COG0544	peptidyl-prolyl cis-trans isomerase activity
HF295_01515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HF295_01535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HF295_01540	COG1185	polyribonucleotide nucleotidyltransferase activity
HF295_01550	COG0481	GTPase activity
HF295_01555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HF295_01560	COG4974	Belongs to the 'phage' integrase family
HF295_01565	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HF295_01580	COG2255	four-way junction helicase activity
HF295_01585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HF295_01590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HF295_01595	COG4869	propanediol catabolic process
HF295_01600	COG0343	queuine tRNA-ribosyltransferase activity
HF295_01605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HF295_01610	COG2239	Acts as a magnesium transporter
HF295_01615	COG2239	Acts as a magnesium transporter
HF295_01625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HF295_01635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HF295_01640	COG1799	cell septum assembly
HF295_01650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HF295_01675	COG0612	Peptidase, M16
HF295_01680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HF295_01695	COG0525	valine-tRNA ligase activity
HF295_01700	COG0285	dihydrofolate synthase activity
HF295_01705	COG2003	Belongs to the UPF0758 family
HF295_01740	COG0629	single-stranded DNA binding
HF295_01745	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HF295_01750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HF295_01760	COG2059	Chromate
HF295_01785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HF295_01800	COG0737	Belongs to the 5'-nucleotidase family
HF295_01805	COG3300	MHYT domain
HF295_01805	COG5001	Diguanylate cyclase
HF295_01810	COG0406	alpha-ribazole phosphatase activity
HF295_01825	COG0326	Molecular chaperone. Has ATPase activity
HF295_01845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HF295_01850	COG2205	protein histidine kinase activity
HF295_01850	COG0784	Response regulator, receiver
HF295_01855	COG1215	transferase activity, transferring glycosyl groups
HF295_01865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HF295_01880	COG0632	four-way junction helicase activity
HF295_01885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HF295_01900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HF295_01915	COG2217	Heavy metal translocating P-type atpase
HF295_01920	COG1523	belongs to the glycosyl hydrolase 13 family
HF295_01930	COG3833	ABC-type maltose transport systems, permease component
HF295_01935	COG1175	transmembrane transport
HF295_01945	COG0366	Alpha amylase catalytic
HF295_01965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HF295_01970	COG0742	ribosomal rna small subunit methyltransferase
HF295_01980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HF295_01980	COG0574	Belongs to the PEP-utilizing enzyme family
HF295_01990	COG4555	ABC transporter
HF295_02000	COG0584	glycerophosphoryl diester phosphodiesterase
HF295_02005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HF295_02015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HF295_02045	COG1668	transmembrane transport
HF295_02050	COG4555	ABC transporter
HF295_02055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HF295_02060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HF295_02070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HF295_02075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HF295_02080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HF295_02090	COG1131	(ABC) transporter
HF295_02110	COG2217	Heavy metal translocating P-type atpase
HF295_02115	COG5002	protein histidine kinase activity
HF295_02120	COG0745	RESPONSE REGULATOR receiver
HF295_02140	COG2801	Transposase and inactivated derivatives
HF295_02165	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HF295_02170	COG1363	Peptidase, m42
HF295_02175	COG0564	pseudouridine synthase activity
HF295_02180	COG3557	Belongs to the UPF0374 family
HF295_02190	COG0513	Belongs to the DEAD box helicase family
HF295_02205	COG0497	DNA recombination
HF295_02215	COG1722	exodeoxyribonuclease VII activity
HF295_02220	COG1570	exodeoxyribonuclease VII activity
HF295_02225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HF295_02240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HF295_02245	COG0569	domain protein
HF295_02255	COG5002	protein histidine kinase activity
HF295_02260	COG0745	RESPONSE REGULATOR receiver
HF295_02265	COG0704	Plays a role in the regulation of phosphate uptake
HF295_02275	COG0581	inorganic phosphate transmembrane transporter activity
HF295_02280	COG0573	inorganic phosphate transmembrane transporter activity
HF295_02290	COG0776	regulation of translation
HF295_02305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HF295_02310	COG1187	pseudouridine synthase activity
HF295_02315	COG1253	flavin adenine dinucleotide binding
HF295_02320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HF295_02330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HF295_02340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HF295_02350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF295_02355	COG1692	metallophosphoesterase
HF295_02365	COG1418	mRNA catabolic process
HF295_02365	COG4372	Transposase
HF295_02370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HF295_02385	COG2996	Protein conserved in bacteria
HF295_02395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HF295_02420	COG1074	ATP-dependent DNA helicase activity
HF295_02445	COG1045	serine acetyltransferase
HF295_02455	COG1104	cysteine desulfurase activity
HF295_02465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF295_02475	COG5001	Diguanylate cyclase
HF295_02480	COG2203	Gaf domain
HF295_02480	COG4251	negative regulation of phosphorylation
HF295_02480	COG5001	Diguanylate cyclase
HF295_02480	COG3706	GGDEF domain
HF295_02485	COG1970	mechanosensitive ion channel activity
HF295_02505	COG1595	DNA-templated transcription, initiation
HF295_02535	COG5646	InterPro IPR014922
HF295_02550	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HF295_02555	COG1307	EDD domain protein, DegV family
HF295_02585	COG2801	Transposase and inactivated derivatives
HF295_02590	COG2801	Transposase and inactivated derivatives
HF295_02600	COG4372	Transposase
HF295_02665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HF295_02670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HF295_02710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HF295_02720	COG1216	Glycosyl transferase, family 2
HF295_02720	COG0463	Glycosyl transferase, family 2
HF295_02725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HF295_02730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HF295_02750	COG4974	Belongs to the 'phage' integrase family
HF295_02860	COG2356	endonuclease I
HF295_02930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HF295_02935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HF295_02940	COG1120	ATPase activity
HF295_02955	COG0668	transmembrane transport
HF295_02965	COG0488	(ABC) transporter
HF295_02990	COG4770	biotin carboxylase activity
HF295_02995	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HF295_03015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HF295_03020	COG1121	(ABC) transporter
HF295_03025	COG0803	Belongs to the bacterial solute-binding protein 9 family
HF295_03055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HF295_03065	COG1126	abc transporter atp-binding protein
HF295_03080	COG5001	Diguanylate cyclase
HF295_03090	COG3426	butyrate kinase activity
HF295_03095	COG0280	phosphate acetyltransferase
HF295_03115	COG1144	Oxidoreductase
HF295_03130	COG2356	endonuclease I
HF295_03155	COG2252	PERMEase
HF295_03165	COG1765	OsmC-like protein
HF295_03170	COG1012	belongs to the aldehyde dehydrogenase family
HF295_03175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HF295_03200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HF295_03210	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HF295_03215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HF295_03220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HF295_03225	COG0534	Mate efflux family protein
HF295_03240	COG0205	6-phosphofructokinase activity
HF295_03250	COG0156	8-amino-7-oxononanoate synthase activity
HF295_03255	COG1063	alcohol dehydrogenase
HF295_03270	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HF295_03275	COG1368	sulfuric ester hydrolase activity
HF295_03280	COG0154	amidase activity
HF295_03290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HF295_03290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HF295_03310	COG4608	Belongs to the ABC transporter superfamily
HF295_03315	COG0444	Belongs to the ABC transporter superfamily
HF295_03325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HF295_03330	COG0601	transmembrane transport
HF295_03345	COG2226	methyltransferase
HF295_03355	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HF295_03365	COG1528	Iron-storage protein
HF295_03400	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HF295_03415	COG1272	protein, Hemolysin III
HF295_03425	COG0698	ribose 5-phosphate isomerase
HF295_03435	COG1126	abc transporter atp-binding protein
HF295_03440	COG0765	amino acid transport
HF295_03450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HF295_03465	COG0174	glutamine synthetase
HF295_03495	COG2081	HI0933 family
HF295_03500	COG4399	Belongs to the UPF0754 family
HF295_03505	COG0708	Exodeoxyribonuclease III
HF295_03540	COG2226	methyltransferase
HF295_03590	COG2226	methyltransferase
HF295_03600	COG2801	Transposase and inactivated derivatives
HF295_03620	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HF295_03630	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HF295_03635	COG0583	DNA-binding transcription factor activity
HF295_03640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HF295_03645	COG2086	electron transfer activity
HF295_03650	COG1960	acyl-CoA dehydrogenase activity
HF295_03660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HF295_03665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HF295_03685	COG5658	integral membrane protein
HF295_03700	COG2217	Heavy metal translocating P-type atpase
HF295_03715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HF295_03720	COG0557	exoribonuclease II activity
HF295_03730	COG0148	phosphopyruvate hydratase activity
HF295_03740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HF295_03755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HF295_03765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HF295_03770	COG0778	Nitroreductase
HF295_03785	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HF295_03795	COG0058	SHG alpha-glucan phosphorylase activity
HF295_03800	COG0297	glycogen (starch) synthase activity
HF295_03805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HF295_03815	COG2137	regulation of response to DNA damage stimulus
HF295_03820	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HF295_03825	COG0653	protein targeting
HF295_03830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HF295_03840	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HF295_03845	COG0495	leucyl-tRNA aminoacylation
HF295_03855	COG1242	4 iron, 4 sulfur cluster binding
HF295_03860	COG0697	spore germination
HF295_03885	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HF295_03890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HF295_03895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HF295_03900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HF295_03905	COG5018	Exonuclease
HF295_03910	COG0322	excinuclease ABC activity
HF295_03915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HF295_03920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HF295_03930	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HF295_03935	COG0195	Participates in both transcription termination and antitermination
HF295_03940	COG0779	Required for maturation of 30S ribosomal subunits
HF295_03950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HF295_03970	COG0301	tRNA thio-modification
HF295_03975	COG1956	GAF domain-containing protein
HF295_03980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HF295_03985	COG0446	pyridine nucleotide-disulphide oxidoreductase
HF295_03995	COG0126	phosphoglycerate kinase activity
HF295_04005	COG3870	Protein conserved in bacteria
HF295_04020	COG0719	Fe-S assembly protein
HF295_04025	COG0822	iron-sulfur transferase activity
HF295_04030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HF295_04035	COG0719	Fe-S assembly protein
HF295_04040	COG0396	ATPase activity
HF295_04045	COG1285	pathogenesis
HF295_04065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HF295_04110	COG2267	carboxylic ester hydrolase activity
HF295_04115	COG2267	carboxylic ester hydrolase activity
HF295_04120	COG0427	acetyl-CoA hydrolase
HF295_04130	COG0410	ABC transporter
HF295_04150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HF295_04155	COG1028	Short-chain dehydrogenase reductase Sdr
HF295_04160	COG0183	Belongs to the thiolase family
HF295_04165	COG1309	transcriptional regulator
HF295_04170	COG4251	negative regulation of phosphorylation
HF295_04170	COG2203	Gaf domain
HF295_04170	COG3706	GGDEF domain
HF295_04170	COG5001	Diguanylate cyclase
HF295_04175	COG1716	ATPase activity
HF295_04175	COG5001	Diguanylate cyclase
HF295_04195	COG3481	metal-dependent phosphohydrolase, HD sub domain
HF295_04200	COG1523	belongs to the glycosyl hydrolase 13 family
HF295_04205	COG0617	tRNA 3'-terminal CCA addition
HF295_04210	COG1739	Uncharacterized protein family UPF0029
HF295_04260	COG1837	Belongs to the UPF0109 family
HF295_04265	COG0228	four-way junction DNA binding
HF295_04280	COG0426	domain, Protein
HF295_04290	COG3579	cysteine-type endopeptidase activity
HF295_04300	COG3579	cysteine-type endopeptidase activity
HF295_04310	COG0493	'glutamate synthase
HF295_04340	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HF295_04345	COG3706	GGDEF domain
HF295_04350	COG0598	Magnesium transport protein CorA
HF295_04360	COG0671	phosphoesterase, PA-phosphatase related
HF295_04380	COG3177	Filamentation induced by cAMP protein fic
HF295_04400	COG1373	ATPase (AAA superfamily
HF295_04420	COG0009	L-threonylcarbamoyladenylate synthase
HF295_04440	COG3177	Filamentation induced by cAMP protein fic
HF295_04625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HF295_04630	COG0758	DNA mediated transformation
HF295_04650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HF295_04700	COG3935	DnaD domain protein
HF295_04715	COG4974	Belongs to the 'phage' integrase family
HF295_04760	COG2514	catechol 2,3-dioxygenase activity
HF295_04770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HF295_04775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF295_04780	COG3681	Belongs to the UPF0597 family
HF295_04785	COG0501	Belongs to the peptidase M48B family
HF295_04810	COG0095	Lipoate-protein ligase
HF295_04820	COG0651	ATP synthesis coupled electron transport
HF295_04825	COG0651	ATP synthesis coupled electron transport
HF295_04830	COG0651	ATP synthesis coupled electron transport
HF295_04855	COG1320	monovalent cation:proton antiporter activity
HF295_04860	COG2212	antiporter activity
HF295_04865	COG1863	multisubunit Na H antiporter MnhE subunit
HF295_04885	COG3022	response to hydroperoxide
HF295_04890	COG1368	sulfuric ester hydrolase activity
HF295_04895	COG2199	diguanylate cyclase activity
HF295_04895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HF295_04915	COG3706	GGDEF domain
HF295_04940	COG5001	Diguanylate cyclase
HF295_04955	COG1373	ATPase (AAA superfamily
HF295_04985	COG0750	zinc metalloprotease
HF295_04990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HF295_05005	COG0233	cytoplasmic translational termination
HF295_05015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HF295_05025	COG0756	dUTP diphosphatase activity
HF295_05030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HF295_05035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HF295_05040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HF295_05045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HF295_05050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF295_05055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HF295_05060	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF295_05065	COG0356	it plays a direct role in the translocation of protons across the membrane
HF295_05080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HF295_05085	COG0546	phosphoglycolate phosphatase activity
HF295_05090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HF295_05095	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HF295_05100	COG0681	Belongs to the peptidase S26 family
HF295_05105	COG1674	ftsk spoiiie
HF295_05115	COG0561	phosphatase activity
HF295_05120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HF295_05125	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HF295_05130	COG0552	protein localization to endoplasmic reticulum
HF295_05135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HF295_05140	COG2890	protein-(glutamine-N5) methyltransferase activity
HF295_05145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HF295_05150	COG0305	Participates in initiation and elongation during chromosome replication
HF295_05155	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HF295_05160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HF295_05165	COG0629	single-stranded DNA binding
HF295_05170	COG0360	Binds together with S18 to 16S ribosomal RNA
HF295_05185	COG1546	Belongs to the CinA family
HF295_05185	COG1058	Belongs to the CinA family
HF295_05190	COG0012	GTP binding
HF295_05195	COG0084	hydrolase, TatD family'
HF295_05200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HF295_05205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HF295_05210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HF295_05215	COG0049	tRNA binding
HF295_05220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HF295_05225	COG0494	nUDIX hydrolase
HF295_05235	COG0753	catalase activity
HF295_05240	COG2832	Protein of unknown function (DUF454)
HF295_05250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HF295_05300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HF295_05305	COG0085	RNA polymerase activity
HF295_05310	COG2813	Specifically methylates the guanine in position
HF295_05315	COG0222	ribosome binding
HF295_05320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HF295_05325	COG0081	regulation of translation
HF295_05335	COG1136	(ABC) transporter
HF295_05340	COG1136	(ABC) transporter
HF295_05340	COG0577	efflux transmembrane transporter activity
HF295_05345	COG0250	Participates in transcription elongation, termination and antitermination
HF295_05355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HF295_05365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HF295_05370	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HF295_05375	COG0215	cysteine-tRNA ligase activity
HF295_05380	COG1278	Cold shock
HF295_05390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HF295_05395	COG3422	double-strand break repair
HF295_05400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HF295_05405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HF295_05415	COG0693	protein deglycase activity
HF295_05420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HF295_05425	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HF295_05430	COG1774	PSP1 C-terminal conserved region
HF295_05435	COG0470	DNA polymerase III
HF295_05440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HF295_05445	COG1121	(ABC) transporter
HF295_05450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HF295_05455	COG0101	tRNA pseudouridine synthase activity
HF295_05465	COG1122	ATPase activity
HF295_05470	COG1122	ATPase activity
HF295_05480	COG0203	ribosomal protein L17
HF295_05490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HF295_05495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF295_05500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HF295_05510	COG0024	Methionine aminopeptidase
HF295_05520	COG0201	protein transport
HF295_05530	COG1841	ribosomal large subunit assembly
HF295_05540	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HF295_05545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HF295_05550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HF295_05555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HF295_05565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HF295_05570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HF295_05580	COG0255	Belongs to the universal ribosomal protein uL29 family
HF295_05590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HF295_05595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HF295_05600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HF295_05605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF295_05610	COG0089	rRNA binding
HF295_05615	COG0088	Forms part of the polypeptide exit tunnel
HF295_05620	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HF295_05625	COG0051	transcription antitermination factor activity, RNA binding
HF295_05630	COG1199	ATP-dependent helicase activity
HF295_05630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HF295_05650	COG1518	maintenance of DNA repeat elements
HF295_05655	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HF295_05660	COG0428	transporter
HF295_05665	COG1979	alcohol dehydrogenase
HF295_05670	COG0584	glycerophosphoryl diester phosphodiesterase
HF295_05675	COG0483	inositol monophosphate 1-phosphatase activity
HF295_05700	COG0656	L-ascorbic acid biosynthetic process
HF295_05715	COG1671	Belongs to the UPF0178 family
HF295_05745	COG3706	GGDEF domain
HF295_05815	COG1475	DNA binding
HF295_05820	COG1192	Involved in chromosome partitioning
HF295_05840	COG0357	Ribosomal RNA small subunit methyltransferase G
HF295_05845	COG0445	tRNA wobble uridine modification
HF295_05865	COG1435	thymidine kinase activity
HF295_05870	COG0254	rRNA binding
HF295_05875	COG0281	malic enzyme
HF295_05885	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HF295_05885	COG0037	tRNA processing
HF295_05890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HF295_05895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HF295_05905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HF295_05925	COG0312	modulator of DNA gyrase
HF295_05930	COG0312	modulator of DNA gyrase
HF295_05935	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HF295_05950	COG1283	sodium-dependent phosphate transmembrane transporter activity
HF295_05955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HF295_05960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HF295_05965	COG2356	endonuclease I
HF295_05985	COG0395	ABC-type sugar transport system, permease component
HF295_05990	COG1175	transmembrane transport
HF295_05995	COG3842	ATPase activity
HF295_06015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HF295_06020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HF295_06025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HF295_06035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HF295_06040	COG0037	tRNA processing
HF295_06065	COG0017	Asparaginyl-tRNA synthetase
HF295_06085	COG2088	sporulation resulting in formation of a cellular spore
HF295_06090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HF295_06100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HF295_06105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HF295_06110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HF295_06115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HF295_06120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HF295_06130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HF295_06135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HF295_06200	COG0592	DNA-directed DNA polymerase activity
HF295_06205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HF295_06215	COG0594	ribonuclease P activity
HF295_06235	COG0537	adenosine 5'-monophosphoramidase activity
HF295_06240	COG0546	phosphoglycolate phosphatase activity
HF295_06245	COG1597	lipid kinase activity
HF295_06250	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HF295_06255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HF295_06260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HF295_06265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HF295_06270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HF295_06300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HF295_06310	COG0463	Glycosyl transferase, family 2
HF295_06315	COG2246	polysaccharide biosynthetic process
HF295_06320	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HF295_06335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HF295_06340	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HF295_06350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HF295_06355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HF295_06360	COG1098	S1 RNA binding domain
HF295_06365	COG0166	Belongs to the GPI family
HF295_06375	COG0802	atpase or kinase
HF295_06380	COG1214	PFAM Peptidase M22, glycoprotease
HF295_06390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HF295_06410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HF295_06425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HF295_06430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HF295_06435	COG1481	regulation of sporulation
HF295_06440	COG0736	holo-[acyl-carrier-protein] synthase activity
HF295_06450	COG2183	response to ionizing radiation
HF295_06505	COG0701	Predicted permease
HF295_06520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HF295_06525	COG0187	DNA topoisomerase II activity
HF295_06530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HF295_06535	COG2501	S4 domain
HF295_06540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HF295_06545	COG0300	oxidoreductase activity
HF295_06565	COG1607	acyl-coa hydrolase
HF295_06570	COG3246	L-lysine catabolic process to acetate
HF295_06575	COG0604	alcohol dehydrogenase
HF295_06580	COG1509	lysine 2,3-aminomutase activity
HF295_06590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HF295_06595	COG5012	cobalamin binding
HF295_06600	COG2096	Adenosyltransferase
HF295_06605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HF295_06625	COG3052	prosthetic group binding
HF295_06635	COG3051	citrate lyase alpha subunit
HF295_06655	COG0534	Mate efflux family protein
HF295_06730	COG1269	ATP hydrolysis coupled proton transport
HF295_06760	COG1394	ATPase activity, coupled to movement of substances
HF295_06780	COG1362	aminopeptidase activity
HF295_06790	COG1011	Hydrolase
HF295_06805	COG0584	glycerophosphoryl diester phosphodiesterase
HF295_06815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HF295_06825	COG1307	EDD domain protein, DegV family
HF295_06830	COG0110	maltose O-acetyltransferase activity
HF295_06855	COG2801	Transposase and inactivated derivatives
HF295_06920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HF295_06925	COG2356	endonuclease I
HF295_06930	COG0827	DNA restriction-modification system
HF295_06935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HF295_06950	COG0587	DNA-directed DNA polymerase activity
HF295_06960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HF295_06985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HF295_07015	COG0640	Transcriptional regulator
HF295_07020	COG2217	Heavy metal translocating P-type atpase
HF295_07085	COG1172	Belongs to the binding-protein-dependent transport system permease family
HF295_07090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HF295_07095	COG1349	DNA-binding transcription factor activity
HF295_07100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HF295_07110	COG0698	ribose 5-phosphate isomerase
HF295_07120	COG2251	uridine kinase activity
HF295_07125	COG0366	Alpha amylase catalytic
HF295_07135	COG1695	Transcriptional regulator
HF295_07150	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HF295_07155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF295_07185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HF295_07195	COG0531	amino acid
HF295_07200	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HF295_07205	COG0732	type I restriction modification DNA specificity domain
HF295_07210	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HF295_07230	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HF295_07330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HF295_07330	COG1522	sequence-specific DNA binding
HF295_07340	COG0693	protein deglycase activity
HF295_07375	COG0513	Belongs to the DEAD box helicase family
HF295_07390	COG4485	Bacterial membrane protein, YfhO
HF295_07410	COG0432	Pfam Uncharacterised protein family UPF0047
HF295_07415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HF295_07425	COG1461	Dihydroxyacetone kinase
HF295_07430	COG0415	Belongs to the DNA photolyase family
HF295_07440	COG3033	Beta-eliminating lyase
HF295_07485	COG2033	superoxide reductase activity
HF295_07495	COG1968	undecaprenyl-diphosphatase activity
HF295_07505	COG3206	protein involved in exopolysaccharide biosynthesis
HF295_07505	COG0489	protein tyrosine kinase activity
HF295_07515	COG0745	RESPONSE REGULATOR receiver
HF295_07520	COG5002	protein histidine kinase activity
HF295_07530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HF295_07550	COG0534	Mate efflux family protein
HF295_07555	COG1132	(ABC) transporter
HF295_07560	COG1073	alpha beta
HF295_07580	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HF295_07585	COG4974	Belongs to the 'phage' integrase family
HF295_07590	COG0366	Alpha amylase catalytic
HF295_07595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HF295_07675	COG1725	Transcriptional regulator
HF295_07685	COG1131	(ABC) transporter
HF295_07695	COG0656	L-ascorbic acid biosynthetic process
HF295_07725	COG3590	peptidase
HF295_07745	COG3447	MASE1 domain protein
HF295_07745	COG5001	Diguanylate cyclase
HF295_07745	COG5002	protein histidine kinase activity
HF295_07800	COG1744	ABC transporter substrate-binding protein PnrA-like
HF295_07830	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HF295_07840	COG4658	electron transport chain
HF295_07845	COG1902	pentaerythritol trinitrate reductase activity
HF295_07875	COG4251	negative regulation of phosphorylation
HF295_07875	COG3706	GGDEF domain
HF295_07875	COG5001	Diguanylate cyclase
HF295_07875	COG2203	Gaf domain
HF295_07885	COG0628	permease
HF295_07895	COG0667	Aldo Keto reductase
HF295_07935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HF295_07940	COG0457	Tetratricopeptide repeat
HF295_07940	COG0705	Rhomboid family
HF295_07945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HF295_07950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HF295_07960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HF295_07975	COG0825	malonyl-CoA metabolic process
HF295_07980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HF295_07980	COG0825	malonyl-CoA metabolic process
HF295_07985	COG0439	Biotin carboxylase
HF295_07990	COG0511	ligase activity, forming carbon-carbon bonds
HF295_07995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HF295_08035	COG1176	ABC-type spermidine putrescine transport system, permease component I
HF295_08060	COG1472	Belongs to the glycosyl hydrolase 3 family
HF295_08065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HF295_08080	COG0436	Aminotransferase
HF295_08085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HF295_08090	COG2819	hydrolase of the alpha beta superfamily
HF295_08105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HF295_08110	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HF295_08115	COG0384	phenazine biosynthesis protein PhzF
HF295_08120	COG2261	transglycosylase associated protein
HF295_08135	COG1506	peptidase
HF295_08135	COG0823	Involved in the tonB-independent uptake of proteins
HF295_08135	COG4946	Tricorn protease homolog
HF295_08175	COG4174	ABC transporter (Permease)
HF295_08180	COG1760	l-serine dehydratase
HF295_08225	COG0504	CTP synthase activity
HF295_08245	COG1373	ATPase (AAA superfamily
HF295_08255	COG0494	nUDIX hydrolase
HF295_08265	COG1937	Protein conserved in bacteria
HF295_08285	COG0432	Pfam Uncharacterised protein family UPF0047
HF295_08325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HF295_08355	COG2199	diguanylate cyclase activity
HF295_08355	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HF295_08360	COG1194	a g-specific adenine glycosylase
HF295_08365	COG0459	protein refolding
HF295_08390	COG0346	lactoylglutathione lyase activity
HF295_08400	COG0400	carboxylic ester hydrolase activity
HF295_08410	COG1131	(ABC) transporter
HF295_08420	COG1902	pentaerythritol trinitrate reductase activity
HF295_08425	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HF295_08450	COG2356	endonuclease I
HF295_08460	COG2309	aminopeptidase activity
HF295_08465	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HF295_08490	COG0405	Gamma-glutamyltransferase
HF295_08500	COG2195	Cleaves the N-terminal amino acid of tripeptides
HF295_08530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HF295_08545	COG3118	belongs to the thioredoxin family
HF295_08550	COG0492	ferredoxin-NADP+ reductase activity
HF295_08575	COG1131	(ABC) transporter
HF295_08585	COG0010	Belongs to the arginase family
HF295_08590	COG1982	Orn Lys Arg decarboxylase major
HF295_08605	COG4656	Part of a membrane complex involved in electron transport
HF295_08630	COG4657	Part of a membrane complex involved in electron transport
HF295_08645	COG2986	histidine ammonia-lyase
HF295_08660	COG1228	amidohydrolase
HF295_08665	COG3404	Formiminotransferase-cyclodeaminase
HF295_08670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HF295_08685	COG0577	efflux transmembrane transporter activity
HF295_08685	COG1136	(ABC) transporter
HF295_08690	COG0156	8-amino-7-oxononanoate synthase activity
HF295_08695	COG0300	oxidoreductase activity
HF295_08705	COG0386	Belongs to the glutathione peroxidase family