locus-tag	class	description
KHQ82_00010	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
KHQ82_00070	COG1132	(ABC) transporter
KHQ82_00075	COG1132	(ABC) transporter
KHQ82_00085	COG0549	Belongs to the carbamate kinase family
KHQ82_00110	COG1309	transcriptional regulator
KHQ82_00125	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KHQ82_00135	COG2059	Chromate
KHQ82_00140	COG0405	Gamma-glutamyltransferase
KHQ82_00145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KHQ82_00170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KHQ82_00175	COG0303	'Molybdopterin
KHQ82_00200	COG0521	Mo-molybdopterin cofactor biosynthetic process
KHQ82_00240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KHQ82_00260	COG0402	S-adenosylhomocysteine deaminase activity
KHQ82_00270	COG2252	PERMEase
KHQ82_00280	COG2414	aldehyde ferredoxin oxidoreductase
KHQ82_00305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KHQ82_00305	COG3608	succinylglutamate desuccinylase aspartoacylase
KHQ82_00310	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KHQ82_00310	COG3608	succinylglutamate desuccinylase aspartoacylase
KHQ82_00315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KHQ82_00330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KHQ82_00330	COG0493	'glutamate synthase
KHQ82_00335	COG0402	S-adenosylhomocysteine deaminase activity
KHQ82_00340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KHQ82_00345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KHQ82_00350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KHQ82_00360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KHQ82_00365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KHQ82_00370	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KHQ82_00375	COG2080	2 iron, 2 sulfur cluster binding
KHQ82_00385	COG2801	Transposase and inactivated derivatives
KHQ82_00505	COG0493	'glutamate synthase
KHQ82_00510	COG0649	NAD binding
KHQ82_00515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KHQ82_00520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KHQ82_00525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KHQ82_00530	COG0651	ATP synthesis coupled electron transport
KHQ82_00535	COG0651	ATP synthesis coupled electron transport
KHQ82_00540	COG1006	Multisubunit Na H antiporter MnhC subunit
KHQ82_00545	COG2111	Na H antiporter
KHQ82_00560	COG2212	antiporter activity
KHQ82_00565	COG1863	multisubunit Na H antiporter MnhE subunit
KHQ82_00575	COG3681	Belongs to the UPF0597 family
KHQ82_00590	COG2814	Major facilitator Superfamily
KHQ82_00605	COG1122	ATPase activity
KHQ82_00615	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KHQ82_00640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KHQ82_00645	COG1609	Transcriptional regulator
KHQ82_00650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KHQ82_00655	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KHQ82_00660	COG0157	Belongs to the NadC ModD family
KHQ82_00665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KHQ82_00670	COG1592	Rubrerythrin
KHQ82_00680	COG2610	gluconate transmembrane transporter activity
KHQ82_00685	COG3835	regulator
KHQ82_00690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KHQ82_00695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KHQ82_00705	COG3457	Alanine racemase
KHQ82_00715	COG5012	cobalamin binding
KHQ82_00725	COG1307	EDD domain protein, DegV family
KHQ82_00730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KHQ82_00750	COG1695	Transcriptional regulator
KHQ82_00760	COG3804	dihydrodipicolinate reductase
KHQ82_00820	COG1272	protein, Hemolysin III
KHQ82_00825	COG1307	EDD domain protein, DegV family
KHQ82_00830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KHQ82_00835	COG1116	anion transmembrane transporter activity
KHQ82_00840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KHQ82_00850	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KHQ82_00855	COG1151	hydroxylamine reductase activity
KHQ82_00905	COG1454	alcohol dehydrogenase
KHQ82_00940	COG1079	Belongs to the binding-protein-dependent transport system permease family
KHQ82_00945	COG1079	Belongs to the binding-protein-dependent transport system permease family
KHQ82_00950	COG3845	ABC transporter
KHQ82_00955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KHQ82_00960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KHQ82_00975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KHQ82_00985	COG0577	efflux transmembrane transporter activity
KHQ82_00985	COG1136	(ABC) transporter
KHQ82_00995	COG0577	efflux transmembrane transporter activity
KHQ82_00995	COG1136	(ABC) transporter
KHQ82_01010	COG2356	endonuclease I
KHQ82_01035	COG0402	S-adenosylhomocysteine deaminase activity
KHQ82_01040	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KHQ82_01045	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KHQ82_01050	COG1079	Belongs to the binding-protein-dependent transport system permease family
KHQ82_01055	COG4603	Belongs to the binding-protein-dependent transport system permease family
KHQ82_01060	COG3845	ABC transporter
KHQ82_01065	COG1744	ABC transporter substrate-binding protein PnrA-like
KHQ82_01075	COG1136	(ABC) transporter
KHQ82_01080	COG0577	efflux transmembrane transporter activity
KHQ82_01080	COG1136	(ABC) transporter
KHQ82_01085	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KHQ82_01105	COG2267	carboxylic ester hydrolase activity
KHQ82_01145	COG3118	belongs to the thioredoxin family
KHQ82_01155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KHQ82_01175	COG3647	Membrane
KHQ82_01180	COG2801	Transposase and inactivated derivatives
KHQ82_01190	COG1966	Carbon starvation protein
KHQ82_01195	COG3279	Response regulator of the LytR AlgR family
KHQ82_01200	COG3275	phosphorelay sensor kinase activity
KHQ82_01210	COG0745	RESPONSE REGULATOR receiver
KHQ82_01215	COG5002	protein histidine kinase activity
KHQ82_01225	COG0673	inositol 2-dehydrogenase activity
KHQ82_01250	COG0494	nUDIX hydrolase
KHQ82_01265	COG1733	regulation of RNA biosynthetic process
KHQ82_01280	COG0456	acetyltransferase
KHQ82_01295	COG3290	protein histidine kinase activity
KHQ82_01300	COG3279	Response regulator of the LytR AlgR family
KHQ82_01355	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
KHQ82_01365	COG0312	modulator of DNA gyrase
KHQ82_01375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KHQ82_01375	COG0723	plastoquinol--plastocyanin reductase activity
KHQ82_01400	COG0116	Belongs to the methyltransferase superfamily
KHQ82_01420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KHQ82_01425	COG4399	Belongs to the UPF0754 family
KHQ82_01445	COG2207	Transcriptional regulator
KHQ82_01445	COG3708	Transcriptional regulator
KHQ82_01450	COG0494	nUDIX hydrolase
KHQ82_01460	COG3639	organic phosphonate transmembrane transporter activity
KHQ82_01465	COG3639	organic phosphonate transmembrane transporter activity
KHQ82_01470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KHQ82_01475	COG0737	Belongs to the 5'-nucleotidase family
KHQ82_01490	COG2267	carboxylic ester hydrolase activity
KHQ82_01495	COG0427	acetyl-CoA hydrolase
KHQ82_01525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KHQ82_01530	COG1028	Short-chain dehydrogenase reductase Sdr
KHQ82_01535	COG0183	Belongs to the thiolase family
KHQ82_01545	COG0765	amino acid transport
KHQ82_01550	COG1126	abc transporter atp-binding protein
KHQ82_01555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHQ82_01570	COG0189	ligase activity
KHQ82_01580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KHQ82_01610	COG1285	pathogenesis
KHQ82_01615	COG0156	8-amino-7-oxononanoate synthase activity
KHQ82_01620	COG1063	alcohol dehydrogenase
KHQ82_01630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KHQ82_01645	COG0436	Aminotransferase
KHQ82_01665	COG1266	CAAX protease self-immunity
KHQ82_01675	COG0697	spore germination
KHQ82_01710	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KHQ82_01715	COG5012	cobalamin binding
KHQ82_01720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KHQ82_01730	COG1509	lysine 2,3-aminomutase activity
KHQ82_01735	COG0384	phenazine biosynthesis protein PhzF
KHQ82_01740	COG0604	alcohol dehydrogenase
KHQ82_01745	COG3246	L-lysine catabolic process to acetate
KHQ82_01750	COG1607	acyl-coa hydrolase
KHQ82_01760	COG2030	dehydratase
KHQ82_01775	COG1331	Highly conserved protein containing a thioredoxin domain
KHQ82_01800	COG0183	Belongs to the thiolase family
KHQ82_01805	COG2031	fatty acid transporter
KHQ82_01815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KHQ82_01945	COG2385	sporulation resulting in formation of a cellular spore
KHQ82_01950	COG2183	response to ionizing radiation
KHQ82_01955	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KHQ82_01960	COG2155	Conserved Protein
KHQ82_01970	COG1481	regulation of sporulation
KHQ82_01975	COG0492	ferredoxin-NADP+ reductase activity
KHQ82_01980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KHQ82_01990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KHQ82_02005	COG5632	N-Acetylmuramoyl-L-alanine amidase
KHQ82_02005	COG3409	Peptidoglycan-binding domain 1 protein
KHQ82_02015	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
KHQ82_02020	COG3051	citrate lyase alpha subunit
KHQ82_02030	COG3052	prosthetic group binding
KHQ82_02050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KHQ82_02055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KHQ82_02065	COG0210	DNA helicase
KHQ82_02080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KHQ82_02085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KHQ82_02090	COG1028	Short-chain dehydrogenase reductase Sdr
KHQ82_02095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KHQ82_02100	COG2070	2-Nitropropane dioxygenase
KHQ82_02105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KHQ82_02110	COG0825	malonyl-CoA metabolic process
KHQ82_02115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KHQ82_02120	COG0439	Biotin carboxylase
KHQ82_02125	COG0511	ligase activity, forming carbon-carbon bonds
KHQ82_02135	COG2070	2-Nitropropane dioxygenase
KHQ82_02140	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KHQ82_02140	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KHQ82_02160	COG0640	Transcriptional regulator
KHQ82_02170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KHQ82_02180	COG1214	PFAM Peptidase M22, glycoprotease
KHQ82_02185	COG0802	atpase or kinase
KHQ82_02190	COG0860	N-Acetylmuramoyl-L-alanine amidase
KHQ82_02200	COG1098	S1 RNA binding domain
KHQ82_02205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KHQ82_02210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KHQ82_02215	COG4470	Protein conserved in bacteria
KHQ82_02225	COG3377	Domain of unknown function (DUF1805)
KHQ82_02240	COG1714	RDD family
KHQ82_02245	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KHQ82_02250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KHQ82_02265	COG1803	Methylglyoxal synthase
KHQ82_02275	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KHQ82_02290	COG0542	response to heat
KHQ82_02310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KHQ82_02315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KHQ82_02320	COG1363	Peptidase, m42
KHQ82_02340	COG1162	GTPase activity
KHQ82_02345	COG2234	aminopeptidase activity
KHQ82_02350	COG2234	aminopeptidase activity
KHQ82_02365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KHQ82_02405	COG0424	maF-like protein
KHQ82_02410	COG2270	Major facilitator Superfamily
KHQ82_02435	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KHQ82_02440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KHQ82_02445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KHQ82_02480	COG1473	amidohydrolase
KHQ82_02490	COG0504	CTP synthase activity
KHQ82_02510	COG1283	sodium-dependent phosphate transmembrane transporter activity
KHQ82_02515	COG1309	transcriptional regulator
KHQ82_02520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KHQ82_02530	COG2217	Heavy metal translocating P-type atpase
KHQ82_02540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KHQ82_02545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KHQ82_02550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KHQ82_02555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KHQ82_02560	COG0037	tRNA processing
KHQ82_02610	COG0017	Asparaginyl-tRNA synthetase
KHQ82_02630	COG0706	membrane insertase activity
KHQ82_02635	COG0594	ribonuclease P activity
KHQ82_02650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KHQ82_02655	COG0592	DNA-directed DNA polymerase activity
KHQ82_02660	COG2501	S4 domain
KHQ82_02665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KHQ82_02670	COG0187	DNA topoisomerase II activity
KHQ82_02675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KHQ82_02690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KHQ82_02695	COG0537	adenosine 5'-monophosphoramidase activity
KHQ82_02710	COG3773	Cell wall hydrolase
KHQ82_02715	COG0280	phosphate acetyltransferase
KHQ82_02725	COG0656	L-ascorbic acid biosynthetic process
KHQ82_02730	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KHQ82_02750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KHQ82_02755	COG2088	sporulation resulting in formation of a cellular spore
KHQ82_02760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KHQ82_02765	COG0488	(ABC) transporter
KHQ82_02775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KHQ82_02780	COG2002	toxin-antitoxin pair type II binding
KHQ82_02810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KHQ82_02915	COG0436	Aminotransferase
KHQ82_02925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KHQ82_02930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KHQ82_02935	COG2171	N-acyltransferase activity
KHQ82_02940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KHQ82_02955	COG2195	Cleaves the N-terminal amino acid of tripeptides
KHQ82_02960	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KHQ82_02970	COG0509	glycine decarboxylation via glycine cleavage system
KHQ82_02975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KHQ82_02985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KHQ82_02990	COG0071	Belongs to the small heat shock protein (HSP20) family
KHQ82_03000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KHQ82_03025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KHQ82_03030	COG4656	Part of a membrane complex involved in electron transport
KHQ82_03035	COG4658	electron transport chain
KHQ82_03045	COG4660	Part of a membrane complex involved in electron transport
KHQ82_03050	COG4657	Part of a membrane complex involved in electron transport
KHQ82_03055	COG2878	Part of a membrane complex involved in electron transport
KHQ82_03070	COG0174	glutamine synthetase
KHQ82_03085	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KHQ82_03085	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KHQ82_03090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KHQ82_03095	COG0254	rRNA binding
KHQ82_03100	COG1435	thymidine kinase activity
KHQ82_03125	COG0745	RESPONSE REGULATOR receiver
KHQ82_03130	COG0445	tRNA wobble uridine modification
KHQ82_03135	COG0357	Ribosomal RNA small subunit methyltransferase G
KHQ82_03140	COG1192	Involved in chromosome partitioning
KHQ82_03145	COG1475	DNA binding
KHQ82_03150	COG4481	Protein conserved in bacteria
KHQ82_03165	COG0628	permease
KHQ82_03205	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KHQ82_03215	COG1132	(ABC) transporter
KHQ82_03290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHQ82_03305	COG4974	Belongs to the 'phage' integrase family
KHQ82_03415	COG1403	HNH endonuclease
KHQ82_03425	COG4974	Belongs to the 'phage' integrase family
KHQ82_03455	COG2382	esterase
KHQ82_03455	COG3507	Belongs to the glycosyl hydrolase 43 family
KHQ82_03455	COG3693	PFAM glycoside hydrolase, family 10
KHQ82_03520	COG0778	Nitroreductase
KHQ82_03545	COG4658	electron transport chain
KHQ82_03555	COG4660	Part of a membrane complex involved in electron transport
KHQ82_03560	COG4657	Part of a membrane complex involved in electron transport
KHQ82_03565	COG2878	Part of a membrane complex involved in electron transport
KHQ82_03590	COG0709	Synthesizes selenophosphate from selenide and ATP
KHQ82_03615	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KHQ82_03635	COG0051	transcription antitermination factor activity, RNA binding
KHQ82_03640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KHQ82_03645	COG0088	Forms part of the polypeptide exit tunnel
KHQ82_03650	COG0089	rRNA binding
KHQ82_03655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KHQ82_03660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KHQ82_03665	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KHQ82_03675	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KHQ82_03680	COG0255	Belongs to the universal ribosomal protein uL29 family
KHQ82_03685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KHQ82_03705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KHQ82_03710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KHQ82_03715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KHQ82_03720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KHQ82_03725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KHQ82_03730	COG1841	ribosomal large subunit assembly
KHQ82_03735	COG0200	Binds to the 23S rRNA
KHQ82_03740	COG0201	protein transport
KHQ82_03745	COG0563	adenylate kinase activity
KHQ82_03750	COG0024	Methionine aminopeptidase
KHQ82_03755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KHQ82_03760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KHQ82_03770	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KHQ82_03775	COG0202	RNA polymerase activity
KHQ82_03780	COG0203	ribosomal protein L17
KHQ82_03790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KHQ82_03825	COG1428	Deoxynucleoside kinase
KHQ82_03845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KHQ82_03850	COG0101	tRNA pseudouridine synthase activity
KHQ82_03855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KHQ82_03860	COG0470	DNA polymerase III
KHQ82_03865	COG1774	PSP1 C-terminal conserved region
KHQ82_03870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KHQ82_03880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KHQ82_03895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KHQ82_03900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KHQ82_03915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KHQ82_03920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KHQ82_03925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KHQ82_03930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KHQ82_03940	COG0151	Belongs to the GarS family
KHQ82_03945	COG0516	GMP reductase activity
KHQ82_03945	COG0517	IMP dehydrogenase activity
KHQ82_03955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KHQ82_03955	COG0519	Catalyzes the synthesis of GMP from XMP
KHQ82_03960	COG2199	diguanylate cyclase activity
KHQ82_03960	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KHQ82_03965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KHQ82_03970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KHQ82_03975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KHQ82_03990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KHQ82_04000	COG0215	cysteine-tRNA ligase activity
KHQ82_04005	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KHQ82_04010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHQ82_04020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KHQ82_04030	COG0250	Participates in transcription elongation, termination and antitermination
KHQ82_04035	COG0494	nUDIX hydrolase
KHQ82_04045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KHQ82_04050	COG0081	regulation of translation
KHQ82_04055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KHQ82_04065	COG2813	Specifically methylates the guanine in position
KHQ82_04075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KHQ82_04080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KHQ82_04085	COG0049	tRNA binding
KHQ82_04095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KHQ82_04105	COG0084	hydrolase, TatD family'
KHQ82_04110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KHQ82_04120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KHQ82_04125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KHQ82_04130	COG0012	GTP binding
KHQ82_04150	COG0360	Binds together with S18 to 16S ribosomal RNA
KHQ82_04155	COG0629	single-stranded DNA binding
KHQ82_04160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KHQ82_04165	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KHQ82_04170	COG0359	binds to the 23S rRNA
KHQ82_04175	COG0305	Participates in initiation and elongation during chromosome replication
KHQ82_04185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KHQ82_04200	COG0009	L-threonylcarbamoyladenylate synthase
KHQ82_04215	COG0698	ribose 5-phosphate isomerase
KHQ82_04220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KHQ82_04240	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KHQ82_04245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KHQ82_04255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KHQ82_04260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KHQ82_04265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KHQ82_04270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KHQ82_04295	COG2385	sporulation resulting in formation of a cellular spore
KHQ82_04305	COG1609	Transcriptional regulator
KHQ82_04310	COG1739	Uncharacterized protein family UPF0029
KHQ82_04325	COG3481	metal-dependent phosphohydrolase, HD sub domain
KHQ82_04340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KHQ82_04345	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KHQ82_04350	COG1396	sequence-specific DNA binding
KHQ82_04360	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KHQ82_04385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KHQ82_04390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHQ82_04395	COG0765	amino acid transport
KHQ82_04430	COG1131	(ABC) transporter
KHQ82_04480	COG1234	tRNA 3'-trailer cleavage
KHQ82_04485	COG0367	asparagine synthase
KHQ82_04500	COG1217	gtp-binding protein TYPA
KHQ82_04505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KHQ82_04510	COG2011	ABC-type metal ion transport system permease component
KHQ82_04515	COG1464	Belongs to the NlpA lipoprotein family
KHQ82_04535	COG2226	methyltransferase
KHQ82_04550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KHQ82_04580	COG0579	oxidoreductase
KHQ82_04600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KHQ82_04605	COG3859	Proton-coupled thiamine transporter YuaJ
KHQ82_04615	COG0778	Nitroreductase
KHQ82_04620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KHQ82_04645	COG1671	Belongs to the UPF0178 family
KHQ82_04655	COG4152	abc transporter atp-binding protein
KHQ82_04660	COG1668	transmembrane transport
KHQ82_04670	COG0312	modulator of DNA gyrase
KHQ82_04695	COG1846	Transcriptional regulator
KHQ82_04700	COG0534	Mate efflux family protein
KHQ82_04705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHQ82_04710	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KHQ82_04715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KHQ82_04720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KHQ82_04730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KHQ82_04740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KHQ82_04745	COG0077	Prephenate dehydratase
KHQ82_04745	COG1605	Chorismate mutase
KHQ82_04755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KHQ82_04760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KHQ82_04765	COG0824	Thioesterase
KHQ82_04770	COG2211	Major facilitator Superfamily
KHQ82_04775	COG0697	spore germination
KHQ82_04795	COG1278	Cold shock
KHQ82_04805	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KHQ82_04810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KHQ82_04815	COG0543	2 iron, 2 sulfur cluster binding
KHQ82_04820	COG0167	dihydroorotate dehydrogenase activity
KHQ82_04825	COG0284	orotidine-5'-phosphate decarboxylase activity
KHQ82_04840	COG1494	fructose-1,6-bisphosphatase
KHQ82_04880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHQ82_04885	COG0765	amino acid transport
KHQ82_04890	COG1126	abc transporter atp-binding protein
KHQ82_04905	COG0396	ATPase activity
KHQ82_04910	COG0719	Fe-S assembly protein
KHQ82_04915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KHQ82_04930	COG0596	Alpha beta hydrolase
KHQ82_04930	COG0596	Alpha beta hydrolase
KHQ82_04940	COG1181	Belongs to the D-alanine--D-alanine ligase family
KHQ82_04960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KHQ82_05025	COG3842	ATPase activity
KHQ82_05035	COG0126	phosphoglycerate kinase activity
KHQ82_05040	COG0149	triose-phosphate isomerase activity
KHQ82_05045	COG2197	response regulator
KHQ82_05065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KHQ82_05075	COG0335	large ribosomal subunit rRNA binding
KHQ82_05095	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KHQ82_05100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KHQ82_05105	COG2137	regulation of response to DNA damage stimulus
KHQ82_05115	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KHQ82_05130	COG0561	phosphatase activity
KHQ82_05140	COG1674	ftsk spoiiie
KHQ82_05150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KHQ82_05155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KHQ82_05165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KHQ82_05170	COG1609	Transcriptional regulator
KHQ82_05185	COG1164	Oligoendopeptidase f
KHQ82_05190	COG0180	Tryptophanyl-tRNA synthetase
KHQ82_05200	COG0601	transmembrane transport
KHQ82_05205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KHQ82_05210	COG0444	Belongs to the ABC transporter superfamily
KHQ82_05215	COG4608	Belongs to the ABC transporter superfamily
KHQ82_05225	COG1393	Belongs to the ArsC family
KHQ82_05230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KHQ82_05240	COG0740	serine-type endopeptidase activity
KHQ82_05260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KHQ82_05265	COG0148	phosphopyruvate hydratase activity
KHQ82_05280	COG0557	exoribonuclease II activity
KHQ82_05285	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KHQ82_05295	COG4974	Belongs to the 'phage' integrase family
KHQ82_05435	COG2801	Transposase and inactivated derivatives
KHQ82_05450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KHQ82_05475	COG1136	(ABC) transporter
KHQ82_05475	COG0577	efflux transmembrane transporter activity
KHQ82_05485	COG0534	Mate efflux family protein
KHQ82_05505	COG2197	response regulator
KHQ82_05515	COG0733	neurotransmitter:sodium symporter activity
KHQ82_05520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KHQ82_05540	COG0789	Transcriptional regulator
KHQ82_05540	COG4978	Transcriptional regulator
KHQ82_05570	COG1902	pentaerythritol trinitrate reductase activity
KHQ82_05575	COG4166	transmembrane transport
KHQ82_05580	COG0601	transmembrane transport
KHQ82_05585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KHQ82_05590	COG0444	Belongs to the ABC transporter superfamily
KHQ82_05595	COG4608	Belongs to the ABC transporter superfamily
KHQ82_05605	COG0006	proline dipeptidase activity
KHQ82_05620	COG2309	aminopeptidase activity
KHQ82_05630	COG0436	Aminotransferase
KHQ82_05635	COG0006	proline dipeptidase activity
KHQ82_05640	COG0006	proline dipeptidase activity
KHQ82_05655	COG0436	Aminotransferase
KHQ82_05680	COG4821	SIS domain
KHQ82_05690	COG0363	glucosamine-6-phosphate deaminase activity
KHQ82_05700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KHQ82_05745	COG2376	Dihydroxyacetone kinase
KHQ82_05755	COG1172	Belongs to the binding-protein-dependent transport system permease family
KHQ82_05760	COG1172	Belongs to the binding-protein-dependent transport system permease family
KHQ82_05765	COG1363	Peptidase, m42
KHQ82_05775	COG0434	BtpA family
KHQ82_05790	COG3033	Beta-eliminating lyase
KHQ82_05810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KHQ82_05810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KHQ82_05815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KHQ82_05820	COG2197	response regulator
KHQ82_05845	COG1028	Short-chain dehydrogenase reductase Sdr
KHQ82_05870	COG0194	GDP metabolic process
KHQ82_05905	COG0489	protein tyrosine kinase activity
KHQ82_05925	COG0489	protein tyrosine kinase activity
KHQ82_05930	COG2894	cell division
KHQ82_05940	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KHQ82_05960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KHQ82_06000	COG1132	(ABC) transporter
KHQ82_06020	COG0534	Mate efflux family protein
KHQ82_06030	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KHQ82_06035	COG0174	glutamine synthetase
KHQ82_06040	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
KHQ82_06045	COG0133	tryptophan synthase activity
KHQ82_06050	COG0513	Belongs to the DEAD box helicase family
KHQ82_06065	COG1752	Esterase of the alpha-beta hydrolase superfamily
KHQ82_06085	COG0739	heme binding
KHQ82_06120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KHQ82_06160	COG1388	LysM domain
KHQ82_06160	COG3858	chitin binding
KHQ82_06215	COG1054	Belongs to the UPF0176 family
KHQ82_06225	COG2176	DNA-directed DNA polymerase activity
KHQ82_06240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KHQ82_06245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHQ82_06245	COG0072	phenylalanine-tRNA ligase activity
KHQ82_06255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KHQ82_06255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KHQ82_06260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KHQ82_06265	COG1162	GTPase activity
KHQ82_06270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KHQ82_06285	COG1461	Dihydroxyacetone kinase
KHQ82_06300	COG0697	spore germination
KHQ82_06330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KHQ82_06335	COG0416	fatty acid biosynthetic process
KHQ82_06345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KHQ82_06355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KHQ82_06380	COG1323	Belongs to the UPF0348 family
KHQ82_06395	COG0275	rRNA processing
KHQ82_06400	COG0768	penicillin binding
KHQ82_06405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KHQ82_06410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KHQ82_06415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KHQ82_06420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KHQ82_06430	COG0482	sulfurtransferase activity
KHQ82_06435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KHQ82_06440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KHQ82_06460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KHQ82_06470	COG3906	Belongs to the UPF0473 family
KHQ82_06475	COG4122	O-methyltransferase activity
KHQ82_06480	COG0826	peptidase U32
KHQ82_06485	COG0826	peptidase U32
KHQ82_06490	COG0572	uridine kinase
KHQ82_06495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KHQ82_06505	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KHQ82_06510	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KHQ82_06520	COG0799	negative regulation of ribosome biogenesis
KHQ82_06525	COG2226	methyltransferase
KHQ82_06535	COG0658	competence protein
KHQ82_06535	COG2333	competence protein COMEC
KHQ82_06545	COG0268	Binds directly to 16S ribosomal RNA
KHQ82_06560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KHQ82_06565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KHQ82_06575	COG1692	metallophosphoesterase
KHQ82_06580	COG2359	stage V sporulation protein S
KHQ82_06590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KHQ82_06600	COG1268	BioY protein
KHQ82_06605	COG0601	transmembrane transport
KHQ82_06610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KHQ82_06615	COG0444	Belongs to the ABC transporter superfamily
KHQ82_06620	COG4608	Belongs to the ABC transporter superfamily
KHQ82_06625	COG4166	transmembrane transport
KHQ82_06645	COG0632	four-way junction helicase activity
KHQ82_06655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KHQ82_06660	COG1760	l-serine dehydratase
KHQ82_06665	COG0343	queuine tRNA-ribosyltransferase activity
KHQ82_06670	COG0772	Belongs to the SEDS family
KHQ82_06675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KHQ82_06680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KHQ82_06690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KHQ82_06700	COG1191	sigma factor activity
KHQ82_06705	COG1191	sigma factor activity
KHQ82_06710	COG1873	PFAM PRC-barrel domain
KHQ82_06715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KHQ82_06720	COG1799	cell septum assembly
KHQ82_06725	COG0762	integral membrane protein
KHQ82_06740	COG0574	Belongs to the PEP-utilizing enzyme family
KHQ82_06740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KHQ82_06745	COG0534	Mate efflux family protein
KHQ82_06755	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KHQ82_06760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KHQ82_06790	COG3557	Belongs to the UPF0374 family
KHQ82_06810	COG0006	proline dipeptidase activity
KHQ82_06815	COG5002	protein histidine kinase activity
KHQ82_06815	COG0784	Response regulator, receiver
KHQ82_06830	COG4667	esterase of the alpha-beta hydrolase superfamily
KHQ82_06840	COG3546	catalase activity
KHQ82_06865	COG2239	Acts as a magnesium transporter
KHQ82_06885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KHQ82_06920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KHQ82_06925	COG1363	Peptidase, m42
KHQ82_06935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KHQ82_06940	COG0006	proline dipeptidase activity
KHQ82_06960	COG1131	(ABC) transporter
KHQ82_06970	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KHQ82_06975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KHQ82_06980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KHQ82_06985	COG0668	transmembrane transport
KHQ82_06995	COG0018	arginyl-trna synthetase
KHQ82_07000	COG1363	Peptidase, m42
KHQ82_07005	COG0742	ribosomal rna small subunit methyltransferase
KHQ82_07010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KHQ82_07030	COG1388	LysM domain
KHQ82_07030	COG3942	CHAP domain
KHQ82_07055	COG1053	succinate dehydrogenase
KHQ82_07060	COG4565	transcriptional regulatory protein
KHQ82_07065	COG3290	protein histidine kinase activity
KHQ82_07070	COG4565	transcriptional regulatory protein
KHQ82_07095	COG2801	Transposase and inactivated derivatives
KHQ82_07105	COG2205	protein histidine kinase activity
KHQ82_07110	COG0745	RESPONSE REGULATOR receiver
KHQ82_07115	COG4591	ABC-type transport system involved in lipoprotein release permease component
KHQ82_07120	COG1136	(ABC) transporter
KHQ82_07145	COG0456	acetyltransferase
KHQ82_07155	COG0745	RESPONSE REGULATOR receiver
KHQ82_07170	COG2205	protein histidine kinase activity
KHQ82_07240	COG1309	transcriptional regulator
KHQ82_07355	COG4974	Belongs to the 'phage' integrase family
KHQ82_07365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KHQ82_07375	COG2217	Heavy metal translocating P-type atpase
KHQ82_07380	COG0544	peptidyl-prolyl cis-trans isomerase activity
KHQ82_07385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KHQ82_07390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KHQ82_07395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KHQ82_07415	COG0525	valine-tRNA ligase activity
KHQ82_07420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KHQ82_07425	COG1307	EDD domain protein, DegV family
KHQ82_07435	COG1982	Orn Lys Arg decarboxylase major
KHQ82_07440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KHQ82_07450	COG0300	oxidoreductase activity
KHQ82_07455	COG0156	8-amino-7-oxononanoate synthase activity
KHQ82_07470	COG1307	EDD domain protein, DegV family
KHQ82_07475	COG0285	dihydrofolate synthase activity
KHQ82_07485	COG2003	Belongs to the UPF0758 family
KHQ82_07495	COG1994	Peptidase M50
KHQ82_07500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KHQ82_07525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KHQ82_07530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KHQ82_07535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KHQ82_07540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KHQ82_07545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KHQ82_07550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KHQ82_07555	COG0393	Putative heavy-metal-binding
KHQ82_07560	COG1253	flavin adenine dinucleotide binding
KHQ82_07570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KHQ82_07570	COG4499	WXG100 protein secretion system (Wss), protein YukC
KHQ82_07580	COG0726	polysaccharide deacetylase
KHQ82_07590	COG0527	aspartate kinase activity
KHQ82_07595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KHQ82_07610	COG1744	ABC transporter substrate-binding protein PnrA-like
KHQ82_07615	COG3845	ABC transporter
KHQ82_07620	COG4603	Belongs to the binding-protein-dependent transport system permease family
KHQ82_07625	COG1079	Belongs to the binding-protein-dependent transport system permease family
KHQ82_07630	COG3033	Beta-eliminating lyase
KHQ82_07635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KHQ82_07645	COG0569	domain protein
KHQ82_07655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KHQ82_07665	COG0622	Phosphoesterase
KHQ82_07680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KHQ82_07695	COG3480	Lon protease (S16) C-terminal proteolytic domain
KHQ82_07705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KHQ82_07710	COG0564	pseudouridine synthase activity
KHQ82_07720	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KHQ82_07725	COG1193	negative regulation of DNA recombination
KHQ82_07730	COG3118	belongs to the thioredoxin family
KHQ82_07735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KHQ82_07740	COG0196	riboflavin kinase activity
KHQ82_07745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KHQ82_07750	COG1185	polyribonucleotide nucleotidyltransferase activity
KHQ82_07755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KHQ82_07760	COG0281	malic enzyme
KHQ82_07770	COG0481	GTPase activity
KHQ82_07775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KHQ82_07785	COG4974	Belongs to the 'phage' integrase family
KHQ82_07790	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KHQ82_07795	COG2364	Membrane
KHQ82_07800	COG0456	acetyltransferase
KHQ82_07800	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KHQ82_07810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KHQ82_07820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KHQ82_07825	COG0187	DNA topoisomerase II activity
KHQ82_07830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KHQ82_07835	COG3763	UPF0154 protein
KHQ82_07845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KHQ82_07855	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KHQ82_07860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KHQ82_07870	COG0316	Belongs to the HesB IscA family
KHQ82_07870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KHQ82_07900	COG5002	protein histidine kinase activity
KHQ82_07900	COG3850	Histidine kinase
KHQ82_07905	COG0745	RESPONSE REGULATOR receiver
KHQ82_07910	COG0577	efflux transmembrane transporter activity
KHQ82_07915	COG1136	(ABC) transporter
KHQ82_07920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHQ82_07935	COG3835	regulator
KHQ82_07950	COG0833	amino acid
KHQ82_07960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KHQ82_07965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KHQ82_08000	COG3118	belongs to the thioredoxin family
KHQ82_08025	COG0358	DNA primase activity
KHQ82_08040	COG0730	response to heat
KHQ82_08045	COG1381	Involved in DNA repair and RecF pathway recombination
KHQ82_08050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KHQ82_08055	COG0295	cytidine deaminase activity
KHQ82_08060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KHQ82_08065	COG1702	phosphate starvation-inducible protein PhoH
KHQ82_08075	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KHQ82_08085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KHQ82_08090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KHQ82_08095	COG0484	heat shock protein binding
KHQ82_08100	COG0443	Heat shock 70 kDa protein
KHQ82_08110	COG1420	regulation of RNA biosynthetic process
KHQ82_08115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KHQ82_08145	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KHQ82_08155	COG1459	type II secretion system
KHQ82_08160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KHQ82_08185	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KHQ82_08190	COG0513	Belongs to the DEAD box helicase family
KHQ82_08195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KHQ82_08205	COG0745	RESPONSE REGULATOR receiver
KHQ82_08210	COG0750	zinc metalloprotease
KHQ82_08215	COG0497	DNA recombination
KHQ82_08220	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KHQ82_08225	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KHQ82_08230	COG1722	exodeoxyribonuclease VII activity
KHQ82_08235	COG1570	exodeoxyribonuclease VII activity
KHQ82_08240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KHQ82_08250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KHQ82_08255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KHQ82_08260	COG0124	histidyl-tRNA synthetase
KHQ82_08270	COG1490	D-aminoacyl-tRNA deacylase activity
KHQ82_08275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KHQ82_08280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KHQ82_08285	COG2244	polysaccharide biosynthetic process
KHQ82_08290	COG2323	membrane
KHQ82_08300	COG0776	regulation of translation
KHQ82_08305	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KHQ82_08315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KHQ82_08325	COG0539	negative regulation of cytoplasmic translation
KHQ82_08330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KHQ82_08340	COG1187	pseudouridine synthase activity
KHQ82_08345	COG0700	Nucleoside recognition
KHQ82_08350	COG2715	membrane protein required for spore maturation
KHQ82_08355	COG1686	Belongs to the peptidase S11 family
KHQ82_08360	COG0697	spore germination
KHQ82_08370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KHQ82_08385	COG2172	sigma factor antagonist activity
KHQ82_08415	COG1686	Belongs to the peptidase S11 family
KHQ82_08420	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KHQ82_08435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KHQ82_08440	COG0629	single-stranded DNA binding
KHQ82_08445	COG0612	Peptidase, M16
KHQ82_08470	COG1321	iron dependent repressor
KHQ82_08475	COG1187	pseudouridine synthase activity
KHQ82_08495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KHQ82_08530	COG2199	diguanylate cyclase activity
KHQ82_08535	COG2033	superoxide reductase activity
KHQ82_08540	COG1592	Rubrerythrin
KHQ82_08580	COG0280	phosphate acetyltransferase
KHQ82_08585	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
KHQ82_08590	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
KHQ82_08595	COG0698	ribose 5-phosphate isomerase
KHQ82_08605	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KHQ82_08625	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
KHQ82_08630	COG4656	Part of a membrane complex involved in electron transport
KHQ82_08635	COG1012	belongs to the aldehyde dehydrogenase family
KHQ82_08645	COG0149	triose-phosphate isomerase activity
KHQ82_08650	COG1609	Transcriptional regulator
KHQ82_08655	COG1278	Cold shock
KHQ82_08660	COG2816	NAD+ diphosphatase activity
KHQ82_08675	COG2226	methyltransferase
KHQ82_08685	COG2909	trisaccharide binding
KHQ82_08700	COG2205	protein histidine kinase activity
KHQ82_08705	COG0745	RESPONSE REGULATOR receiver
KHQ82_08715	COG0582	viral genome integration into host DNA
KHQ82_08735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KHQ82_08790	COG1837	Belongs to the UPF0109 family
KHQ82_08795	COG0228	four-way junction DNA binding
KHQ82_08815	COG2244	polysaccharide biosynthetic process
KHQ82_08830	COG0242	peptide deformylase activity
KHQ82_08835	COG2801	Transposase and inactivated derivatives
KHQ82_08845	COG0561	phosphatase activity
KHQ82_08850	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KHQ82_08855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KHQ82_08885	COG2197	response regulator
KHQ82_08900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KHQ82_08905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KHQ82_08915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KHQ82_08920	COG0195	Participates in both transcription termination and antitermination
KHQ82_08925	COG0779	Required for maturation of 30S ribosomal subunits
KHQ82_08930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHQ82_08980	COG1028	Short-chain dehydrogenase reductase Sdr
KHQ82_08980	COG0604	alcohol dehydrogenase
KHQ82_08980	COG3321	synthase
KHQ82_09040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KHQ82_09055	COG2205	protein histidine kinase activity
KHQ82_09060	COG0745	RESPONSE REGULATOR receiver
KHQ82_09075	COG3591	Belongs to the peptidase S1B family
KHQ82_09085	COG0301	tRNA thio-modification
KHQ82_09090	COG1956	GAF domain-containing protein
KHQ82_09105	COG1307	EDD domain protein, DegV family
KHQ82_09110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KHQ82_09125	COG5522	Integral membrane protein (intg_mem_TP0381)
KHQ82_09135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KHQ82_09155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KHQ82_09160	COG3383	formate dehydrogenase (NAD+) activity
KHQ82_09195	COG1136	(ABC) transporter
KHQ82_09195	COG0577	efflux transmembrane transporter activity
KHQ82_09205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KHQ82_09245	COG0444	Belongs to the ABC transporter superfamily
KHQ82_09250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KHQ82_09255	COG0601	transmembrane transport
KHQ82_09260	COG4166	transmembrane transport
KHQ82_09275	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KHQ82_09280	COG1132	(ABC) transporter
KHQ82_09285	COG1132	(ABC) transporter
KHQ82_09295	COG1247	-acetyltransferase
KHQ82_09305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KHQ82_09310	COG0789	Transcriptional regulator
KHQ82_09320	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KHQ82_09335	COG1132	(ABC) transporter
KHQ82_09340	COG1132	(ABC) transporter
KHQ82_09355	COG0798	PFAM Bile acid sodium symporter
KHQ82_09380	COG1131	(ABC) transporter
KHQ82_09395	COG3426	butyrate kinase activity
KHQ82_09400	COG0280	phosphate acetyltransferase
KHQ82_09405	COG1363	Peptidase, m42
KHQ82_09430	COG0393	Putative heavy-metal-binding
KHQ82_09440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KHQ82_09445	COG1045	serine acetyltransferase
KHQ82_09510	COG0442	prolyl-tRNA aminoacylation
KHQ82_09515	COG0750	zinc metalloprotease
KHQ82_09520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KHQ82_09525	COG4589	Belongs to the CDS family
KHQ82_09530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KHQ82_09535	COG0233	cytoplasmic translational termination
KHQ82_09540	COG0528	UMP kinase activity
KHQ82_09545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KHQ82_09550	COG0052	Belongs to the universal ribosomal protein uS2 family
KHQ82_09555	COG0756	dUTP diphosphatase activity
KHQ82_09560	COG4974	Belongs to the 'phage' integrase family
KHQ82_09565	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KHQ82_09570	COG0251	oxidation-reduction process
KHQ82_09585	COG1597	lipid kinase activity
KHQ82_09590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KHQ82_09600	COG2226	methyltransferase
KHQ82_09605	COG1484	DNA-dependent DNA replication
KHQ82_09615	COG0237	dephospho-CoA kinase activity
KHQ82_09620	COG0731	radical SAM domain protein
KHQ82_09620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KHQ82_09625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KHQ82_09630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KHQ82_09630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KHQ82_09635	COG1876	peptidase activity
KHQ82_09665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KHQ82_09680	COG0552	protein localization to endoplasmic reticulum
KHQ82_09685	COG0495	leucyl-tRNA aminoacylation
KHQ82_09695	COG1115	amino acid carrier protein
KHQ82_09700	COG1242	4 iron, 4 sulfur cluster binding
KHQ82_09710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KHQ82_09720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KHQ82_09730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KHQ82_09735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KHQ82_09740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KHQ82_09745	COG1758	RNA polymerase activity
KHQ82_09750	COG0194	GDP metabolic process
KHQ82_09755	COG1293	RNA-binding protein homologous to eukaryotic snRNP
KHQ82_09765	COG2801	Transposase and inactivated derivatives
KHQ82_09770	COG0602	queuosine metabolic process
KHQ82_09775	COG0488	(ABC) transporter
KHQ82_09780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KHQ82_09815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KHQ82_09840	COG0736	holo-[acyl-carrier-protein] synthase activity
KHQ82_09845	COG0556	nucleotide-excision repair
KHQ82_09850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KHQ82_09860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KHQ82_09865	COG1032	radical SAM domain protein
KHQ82_09880	COG0205	6-phosphofructokinase activity
KHQ82_09885	COG0587	DNA-directed DNA polymerase activity
KHQ82_09900	COG3409	Peptidoglycan-binding domain 1 protein
KHQ82_09900	COG5632	N-Acetylmuramoyl-L-alanine amidase
KHQ82_09905	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KHQ82_09915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KHQ82_09940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KHQ82_09960	COG0367	asparagine synthase
KHQ82_09970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KHQ82_09985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KHQ82_09995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KHQ82_10005	COG0175	sulfate reduction
KHQ82_10010	COG0529	Catalyzes the synthesis of activated sulfate
KHQ82_10020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KHQ82_10030	COG1840	ABC-type Fe3 transport system, periplasmic component
KHQ82_10035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KHQ82_10040	COG0827	DNA restriction-modification system
KHQ82_10045	COG3874	Sporulation protein YtfJ
KHQ82_10055	COG0367	asparagine synthase
KHQ82_10060	COG4667	esterase of the alpha-beta hydrolase superfamily
KHQ82_10065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KHQ82_10075	COG1473	amidohydrolase
KHQ82_10080	COG1968	undecaprenyl-diphosphatase activity
KHQ82_10095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KHQ82_10110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KHQ82_10135	COG1509	lysine 2,3-aminomutase activity
KHQ82_10180	COG1136	(ABC) transporter
KHQ82_10180	COG0577	efflux transmembrane transporter activity
KHQ82_10190	COG1309	transcriptional regulator
KHQ82_10210	COG1733	regulation of RNA biosynthetic process
KHQ82_10230	COG0745	RESPONSE REGULATOR receiver
KHQ82_10235	COG5002	protein histidine kinase activity
KHQ82_10265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KHQ82_10270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KHQ82_10275	COG2081	HI0933 family
KHQ82_10285	COG0640	Transcriptional regulator
KHQ82_10295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KHQ82_10315	COG1597	lipid kinase activity
KHQ82_10370	COG1714	RDD family
KHQ82_10375	COG2197	response regulator
KHQ82_10380	COG4585	Histidine kinase
KHQ82_10395	COG1454	alcohol dehydrogenase
KHQ82_10405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KHQ82_10415	COG1846	Transcriptional regulator
KHQ82_10425	COG1979	alcohol dehydrogenase
KHQ82_10430	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KHQ82_10435	COG0402	S-adenosylhomocysteine deaminase activity
KHQ82_10445	COG1079	Belongs to the binding-protein-dependent transport system permease family
KHQ82_10455	COG3845	ABC transporter
KHQ82_10515	COG2304	oxidoreductase activity
KHQ82_10540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KHQ82_10550	COG3655	Transcriptional regulator
KHQ82_10565	COG5505	Protein of unknown function (DUF819)
KHQ82_10590	COG1309	transcriptional regulator
KHQ82_10635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KHQ82_10675	COG1476	TRANSCRIPTIONal