locus-tag class description TepiRe1_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) TepiRe1_0003 ENOG4105WQ3 Rna-binding protein TepiRe1_0004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) TepiRe1_0007 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TepiRe1_0008 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TepiRe1_0009 ENOG4105CXN decarboxylase TepiRe1_0010 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) TepiRe1_0011 ENOG4105X0R protein from nitrogen regulatory protein P-II TepiRe1_0012 ENOG4105XVJ Protein of unknown function (DUF327) TepiRe1_0014 ENOG4105MA4 psp1 domain protein TepiRe1_0016 ENOG4108JUB Transcriptional regulator TepiRe1_0017 ENOG4105MWK D-amino acid dehydrogenase, small subunit TepiRe1_0018 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TepiRe1_0020 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) TepiRe1_0035 ENOG4105II7 pyrroline-5-carboxylate reductase TepiRe1_0036 ENOG4105KRN Transcriptional regulator, abrb family TepiRe1_0039 ENOG4108IMY Transcriptional regulator TepiRe1_0040 ENOG4105DC7 peptidase M24 TepiRe1_0042 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TepiRe1_0043 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TepiRe1_0045 ENOG4108JQ7 (ABC) transporter TepiRe1_0046 ENOG4105C6N Formate acetyltransferase TepiRe1_0047 ENOG4105F1A Pyruvate formate-lyase TepiRe1_0048 ENOG4105C26 Dehydrogenase TepiRe1_0051 ENOG4105C6Z Gluconate TepiRe1_0054 ENOG4105CK1 PTS System TepiRe1_0055 ENOG4105CS2 ec 3.2.1.21 TepiRe1_0056 ENOG4105VCP PTS System TepiRe1_0060 ENOG4105CFC Transporter TepiRe1_0062 ENOG4105CH2 amidohydrolase TepiRe1_0070 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein TepiRe1_0073 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) TepiRe1_0076 ENOG4105F8V Hydrolase, tatD family TepiRe1_0078 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) TepiRe1_0079 ENOG4108XRC Protein of unknown function (DUF458) TepiRe1_0081 ENOG4105XFA sporulation peptidase YabG TepiRe1_0082 ENOG4105JFG SpoIID LytB domain protein TepiRe1_0083 ENOG4105W42 Veg protein TepiRe1_0085 ENOG4105K4I Scp-like extracellular TepiRe1_0088 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) TepiRe1_0089 ENOG4105DRR Transcriptional regulator, GntR family TepiRe1_0090 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) TepiRe1_0091 ENOG4105DFT pur operon repressor TepiRe1_0092 ENOG4105K4W Could be involved in septation (By similarity) TepiRe1_0093 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) TepiRe1_0094 ENOG4105C5T Phosphoribosyl pyrophosphate synthase TepiRe1_0095 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) TepiRe1_0096 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) TepiRe1_0100 ENOG4105CBX hi0933 family TepiRe1_0101 ENOG4108IMY Transcriptional regulator TepiRe1_0103 ENOG4105K63 Thioredoxin TepiRe1_0105 ENOG4105DSE periplasmic solute binding protein TepiRe1_0106 ENOG4105FDK ABC transporter TepiRe1_0108 ENOG4105N80 Ferric uptake regulator, Fur family TepiRe1_0115 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) TepiRe1_0117 ENOG4107YT1 Glutamate mutase subunit sigma TepiRe1_0119 ENOG4105DJI Methylaspartate mutase, E subunit TepiRe1_0120 ENOG4105DV9 Methylaspartate ammonia-lyase TepiRe1_0121 ENOG4105DV9 Methylaspartate ammonia-lyase TepiRe1_0125 ENOG4105PTM secreted protein TepiRe1_0144 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit TepiRe1_0145 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ TepiRe1_0146 ENOG4105CG6 trap dicarboxylate transporter dctm subunit TepiRe1_0153 ENOG4108JUB Transcriptional regulator TepiRe1_0154 ENOG4105DFM M18 family aminopeptidase TepiRe1_0155 ENOG4105DFM M18 family aminopeptidase TepiRe1_0158 ENOG4108SAX Membrane TepiRe1_0160 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) TepiRe1_0161 ENOG4105NBU tryptophan transport protein TepiRe1_0166 ENOG4107SDT Homocitrate synthase TepiRe1_0167 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TepiRe1_0168 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) TepiRe1_0169 ENOG4105DBK s4 domain protein TepiRe1_0171 ENOG4105G6Z alkaline phosphatase TepiRe1_0172 ENOG4105G6Z alkaline phosphatase TepiRe1_0174 ENOG4105KME endoribonuclease L-psp TepiRe1_0175 ENOG4105C7B Threonine dehydratase TepiRe1_0176 ENOG410667J hydrolase TepiRe1_0178 ENOG4105UQX Mate efflux family protein TepiRe1_0181 ENOG4108JA2 transcriptioN-repair coupling factor TepiRe1_0183 ENOG4108M14 stage v sporulation protein t TepiRe1_0184 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase TepiRe1_0185 ENOG4105CKP Polysaccharide Biosynthesis Protein TepiRe1_0186 ENOG4105DXN mazG family TepiRe1_0193 ENOG41060GV RNA binding s1 domain protein TepiRe1_0195 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TepiRe1_0196 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TepiRe1_0198 ENOG4105XPM ribosomal protein TepiRe1_0199 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) TepiRe1_0200 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) TepiRe1_0201 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TepiRe1_0202 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) TepiRe1_0203 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) TepiRe1_0204 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) TepiRe1_0205 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) TepiRe1_0206 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity TepiRe1_0207 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) TepiRe1_0208 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) TepiRe1_0209 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) TepiRe1_0211 ENOG41082SA 50s ribosomal protein l29 TepiRe1_0212 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal TepiRe1_0213 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) TepiRe1_0214 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) TepiRe1_0215 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits TepiRe1_0216 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) TepiRe1_0217 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) TepiRe1_0218 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) TepiRe1_0219 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) TepiRe1_0220 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) TepiRe1_0221 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) TepiRe1_0222 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) TepiRe1_0223 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) TepiRe1_0224 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) TepiRe1_0226 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) TepiRe1_0227 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits TepiRe1_0228 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) TepiRe1_0229 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) TepiRe1_0230 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TepiRe1_0231 ENOG4108ZT0 50S ribosomal protein l17 TepiRe1_0232 ENOG4108JJB ABC transporter TepiRe1_0234 ENOG4108JJB ABC transporter TepiRe1_0235 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) TepiRe1_0236 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) TepiRe1_0237 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) TepiRe1_0238 ENOG4108UJD 30S ribosomal protein S9 TepiRe1_0239 ENOG4107QW8 radical SAM domain protein TepiRe1_0240 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) TepiRe1_0241 ENOG4105UQX Mate efflux family protein TepiRe1_0244 ENOG4107T2D Phosphoribosylaminoimidazolesuccinocarboxamide synthase TepiRe1_0245 ENOG4105C3M thioredoxin reductase TepiRe1_0247 ENOG4105DBV ornithine carbamoyltransferase TepiRe1_0249 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) TepiRe1_0250 ENOG4105CRK lysyL-tRNA synthetase TepiRe1_0256 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes TepiRe1_0261 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) TepiRe1_0267 ENOG4107U53 septum site-determining protein minD TepiRe1_0267 ENOG4107U53 septum site-determining protein minD TepiRe1_0268 ENOG4105VYW UPF0251 protein TepiRe1_0276 ENOG4105D17 glycoside hydrolase, family 3 domain protein TepiRe1_0284 ENOG41080HT Transcriptional regulator, arsr family TepiRe1_0286 ENOG4108SHJ s-layer protein TepiRe1_0298 ENOG4105D2N Aldolase TepiRe1_0299 ENOG4105CPQ Dehydrogenase TepiRe1_0300 ENOG4105F3R pts system mannose fructose sorbose family iid TepiRe1_0301 ENOG4105ETZ PTS System TepiRe1_0302 ENOG4108IQ3 PTS system TepiRe1_0312 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) TepiRe1_0313 ENOG4108Z5V transcriptional regulator, merr family TepiRe1_0314 ENOG4108UM1 dedA family TepiRe1_0319 ENOG4105RYY domain protein TepiRe1_0325 ENOG4108Q52 Methyltransferase cognate corrinoid protein TepiRe1_0326 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) TepiRe1_0328 ENOG4108Q52 Methyltransferase cognate corrinoid protein TepiRe1_0335 ENOG4108Q52 Methyltransferase cognate corrinoid protein TepiRe1_0339 ENOG410908R Methenyltetrahydrofolate cyclohydrolase TepiRe1_0340 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) TepiRe1_0344 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) TepiRe1_0345 ENOG4108Q52 Methyltransferase cognate corrinoid protein TepiRe1_0347 ENOG4107414 GntR family transcriptional regulator TepiRe1_0348 ENOG4107GBW cellulosome anchoring protein cohesin TepiRe1_0351 ENOG4105BZU Histidine kinase TepiRe1_0353 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) TepiRe1_0355 ENOG4105HKU nucleoside recognition domain-containing protein TepiRe1_0356 ENOG4105HKU nucleoside recognition domain-containing protein TepiRe1_0359 ENOG4105C8B TIGR00159 family TepiRe1_0361 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) TepiRe1_0362 ENOG4105C1A potassium transporter peripheral membrane TepiRe1_0363 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) TepiRe1_0366 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) TepiRe1_0368 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein TepiRe1_0370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TepiRe1_0371 ENOG4108JQ6 ABC transporter TepiRe1_0374 ENOG4105CNW domain protein TepiRe1_0375 ENOG4105C59 p-type ATPase TepiRe1_0376 ENOG4108UIN ybak prolyl-trna synthetase associated region TepiRe1_0380 ENOG4105DGA Diaminopimelate dehydrogenase TepiRe1_0381 ENOG4105UQX Mate efflux family protein TepiRe1_0383 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) TepiRe1_0384 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) TepiRe1_0385 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor TepiRe1_0386 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor TepiRe1_0390 ENOG4105PW4 Sugar fermentation stimulation protein homolog TepiRe1_0395 ENOG4107SJS nitrite reductase, (NAD(P)H) TepiRe1_0396 ENOG4105VCQ rubredoxin TepiRe1_0397 ENOG4105KY8 Rubrerythrin TepiRe1_0398 ENOG4105CPF Cell wall formation (By similarity) TepiRe1_0403 ENOG4108ZJI phenylacetic acid degradation protein TepiRe1_0404 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) TepiRe1_0411 ENOG4105VRS hydrolase family 18 TepiRe1_0413 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein TepiRe1_0414 ENOG4105BZ8 glutamate synthase TepiRe1_0417 ENOG4105CIZ coA-substrate-specific enzyme activase TepiRe1_0418 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) TepiRe1_0419 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit TepiRe1_0426 ENOG4105CJN penicillin-binding protein TepiRe1_0428 ENOG4108IV0 ABC, transporter TepiRe1_0429 ENOG4105C0Z ABC transporter TepiRe1_0430 ENOG4105CF8 branched-chain amino acid ABC transporter, permease TepiRe1_0431 ENOG4105C32 Amino acid ABC transporter (Permease) TepiRe1_0436 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) TepiRe1_0437 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) TepiRe1_0440 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) TepiRe1_0444 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TepiRe1_0445 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TepiRe1_0450 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin TepiRe1_0453 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) TepiRe1_0464 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC TepiRe1_0465 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) TepiRe1_0466 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family TepiRe1_0467 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family TepiRe1_0468 ENOG4105F4R Transcriptional regulator mode TepiRe1_0470 ENOG4105EHG Permease protein TepiRe1_0471 ENOG4105E0A ABC, transporter TepiRe1_0472 ENOG4105S10 periplasmic binding protein TepiRe1_0473 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) TepiRe1_0474 ENOG4105VFE sira family TepiRe1_0475 ENOG4105C3J Cysteine desulfurase TepiRe1_0481 ENOG4107W7X Aldolase TepiRe1_0482 ENOG4105C5I Dehydrogenase TepiRe1_0485 ENOG4105C28 cystathionine TepiRe1_0486 ENOG4105CMG Carbohydrate kinase TepiRe1_0488 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TepiRe1_0490 ENOG4105C3U ABC transporter TepiRe1_0491 ENOG4108JQ7 (ABC) transporter TepiRe1_0492 ENOG4107QSE Dipeptidase TepiRe1_0493 ENOG4105CEM UPF0597 protein TepiRe1_0494 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) TepiRe1_0495 ENOG4108JJB ABC transporter TepiRe1_0496 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) TepiRe1_0497 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein TepiRe1_0498 ENOG41081F0 Precorrin-8x methylmutase TepiRe1_0501 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase TepiRe1_0503 ENOG4105CIA precorrin-4 C(11)-methyltransferase TepiRe1_0504 ENOG4108P62 biosynthesis protein (CbiG) TepiRe1_0505 ENOG4105E4R Precorrin-3B C17-methyltransferase TepiRe1_0507 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) TepiRe1_0508 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) TepiRe1_0510 ENOG4105D52 delta-aminolevulinic acid dehydratase TepiRe1_0511 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) TepiRe1_0512 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase TepiRe1_0513 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) TepiRe1_0514 ENOG4105CE4 GlcNAc 6-P deacetylase TepiRe1_0515 ENOG4106N3A copper homeostasis protein cutc TepiRe1_0517 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) TepiRe1_0520 ENOG4105EQD regulatoR TepiRe1_0521 ENOG4105C2F Histidine kinase TepiRe1_0522 ENOG4105C2J ABC transporter TepiRe1_0523 ENOG4105C2J ABC transporter TepiRe1_0524 ENOG4105CNN ABC, transporter TepiRe1_0529 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) TepiRe1_0530 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) TepiRe1_0531 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TepiRe1_0533 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) TepiRe1_0535 ENOG4108ESY Metal dependent phosphohydrolase TepiRe1_0537 ENOG4108ME1 Peptidase M55 D-aminopeptidase TepiRe1_0538 ENOG4105CD3 dihydroorotase TepiRe1_0539 ENOG4105K8N protein family UPF0079, ATPase TepiRe1_0540 ENOG41072GX Peptidase M22 Glycoprotease TepiRe1_0541 ENOG410801F ribosomal-protein-alanine acetyltransferase TepiRe1_0542 ENOG4108S4C acetyltransferase TepiRe1_0543 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TepiRe1_0544 ENOG4105C5H ABC transporter TepiRe1_0547 ENOG4105C6K Malic enzyme TepiRe1_0551 ENOG4108SHJ s-layer protein TepiRe1_0552 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator TepiRe1_0553 ENOG4105KT7 mgtC SapB transporter TepiRe1_0554 ENOG4105D00 flagellar biosynthetic protein flhB TepiRe1_0556 ENOG4105C7N Xanthine uracil vitamin C permease TepiRe1_0559 ENOG4107WUB V-type ATPase 116 kDa subunit TepiRe1_0560 ENOG410839E ATP synthase, F0 subunit c TepiRe1_0563 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) TepiRe1_0564 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) TepiRe1_0565 ENOG4106C6A Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) TepiRe1_0583 ENOG4105C79 DNA protecting protein DprA TepiRe1_0592 ENOG4105E5G Alpha beta hydrolase fold TepiRe1_0596 ENOG4105EE0 oxidoreductase TepiRe1_0597 ENOG4108XIB electron transport protein ysaA TepiRe1_0598 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit TepiRe1_0599 ENOG41080XS Cobyrinic acid ac-diamide synthase TepiRe1_0600 ENOG4105CKU formyltetrahydrofolate synthetase TepiRe1_0602 ENOG410908R Methenyltetrahydrofolate cyclohydrolase TepiRe1_0603 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) TepiRe1_0604 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) TepiRe1_0607 ENOG4105SYT Methylenetetrahydrofolate reductase TepiRe1_0610 ENOG4106HYN CO dehydrogenase acetyl-CoA synthase delta subunit TepiRe1_0611 ENOG4105EYX Acetyl-CoA decarbonylase synthase complex subunit gamma TepiRe1_0612 ENOG4107VP5 methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase TepiRe1_0613 ENOG4105E8X CO dehydrogenase acetyl-CoA synthase complex beta subunit TepiRe1_0614 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) TepiRe1_0620 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) TepiRe1_0621 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator TepiRe1_0622 ENOG41062EX TepiRe1_0623 ENOG410641M TepiRe1_0624 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) TepiRe1_0625 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A TepiRe1_0628 ENOG4108JUA Transcriptional regulator TepiRe1_0629 ENOG4108NVR Methyl-accepting chemotaxis TepiRe1_0630 ENOG4105CMT Dihydroxyacetone kinase TepiRe1_0632 ENOG4105VDH Dihydroxyacetone kinase TepiRe1_0634 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme TepiRe1_0636 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TepiRe1_0639 ENOG4108UVJ appr-1-p processing domain protein TepiRe1_0640 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase TepiRe1_0641 ENOG4105CJT Mannose-1-phosphate guanylyltransferase TepiRe1_0642 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR TepiRe1_0647 ENOG4105C3G gtp-binding protein TepiRe1_0650 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) TepiRe1_0654 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase TepiRe1_0655 ENOG4108U5N UPF0316 protein TepiRe1_0657 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) TepiRe1_0658 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) TepiRe1_0660 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation TepiRe1_0661 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TepiRe1_0662 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) TepiRe1_0663 ENOG4108IUQ atp-dependent protease TepiRe1_0664 ENOG4105VRS hydrolase family 18 TepiRe1_0666 ENOG4107QSE Dipeptidase TepiRe1_0667 ENOG4105KGF protein, YerC YecD TepiRe1_0671 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TepiRe1_0673 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) TepiRe1_0674 ENOG4105DT3 PTS system, galactitol-specific IIc component TepiRe1_0675 ENOG4105CPQ Dehydrogenase TepiRe1_0676 ENOG4105CPQ Dehydrogenase TepiRe1_0692 ENOG4107RHR regulatoR TepiRe1_0694 ENOG410787A Pts system, glucitol sorbitol-specific TepiRe1_0695 ENOG4105DZY Pts system, glucitol sorbitol-specific TepiRe1_0698 ENOG4107RUY (E1 component), alpha subunit TepiRe1_0699 ENOG4105CPP Dehydrogenase, E1 component TepiRe1_0702 ENOG4108IJ0 Aspartate ammonia-lyase TepiRe1_0703 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) TepiRe1_0704 ENOG4105ETE Transcriptional regulator (LacI family TepiRe1_0705 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TepiRe1_0706 ENOG4105C2J ABC transporter TepiRe1_0707 ENOG4105CNN ABC, transporter TepiRe1_0708 ENOG4105CPQ Dehydrogenase TepiRe1_0709 ENOG4105CPQ Dehydrogenase TepiRe1_0710 ENOG4107W9I Creatinine amidohydrolase TepiRe1_0711 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) TepiRe1_0712 ENOG4107S8A protein TIM barrel TepiRe1_0718 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) TepiRe1_0719 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) TepiRe1_0721 ENOG4105ECC imidazole-glycerol-phosphate dehydratase TepiRe1_0722 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase TepiRe1_0723 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) TepiRe1_0724 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase TepiRe1_0728 ENOG4108UH6 UPF0754 membrane protein TepiRe1_0728 ENOG4108UH6 UPF0754 membrane protein TepiRe1_0729 ENOG4105C22 threonyL-tRNA synthetase TepiRe1_0730 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) TepiRe1_0732 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) TepiRe1_0733 ENOG4105CZN Potassium uptake protein TepiRe1_0735 ENOG4108RWN rrna methyltransferase TepiRe1_0736 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) TepiRe1_0737 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) TepiRe1_0738 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) TepiRe1_0739 ENOG4105DCG PHP domain protein TepiRe1_0740 ENOG4105C98 muts2 protein TepiRe1_0743 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) TepiRe1_0748 ENOG4105EQI Metal Dependent Phosphohydrolase TepiRe1_0749 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) TepiRe1_0750 ENOG41086CI Bifunctional phosphoglucose phosphomannose isomerase TepiRe1_0751 ENOG4105DCG PHP domain protein TepiRe1_0752 ENOG4105F0I Aminotransferase TepiRe1_0754 ENOG4105D4A Cell wall formation (By similarity) TepiRe1_0760 ENOG4105CJW magnesium transporter TepiRe1_0761 ENOG4105CJW magnesium transporter TepiRe1_0762 ENOG41084CE UPF0342 protein TepiRe1_0763 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) TepiRe1_0764 ENOG4105CHW UPF0052 protein TepiRe1_0765 ENOG4105CIE May be required for sporulation (By similarity) TepiRe1_0766 ENOG4105KRI phosphocarrier protein (HPr TepiRe1_0768 ENOG4105C0B DNA polymerase III (alpha subunit) TepiRe1_0770 ENOG4105CTQ phosphohexokinase TepiRe1_0772 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 TepiRe1_0774 ENOG4105EPR degv family TepiRe1_0777 ENOG4105ETE Transcriptional regulator (LacI family TepiRe1_0778 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) TepiRe1_0780 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) TepiRe1_0782 ENOG4105C2J ABC transporter TepiRe1_0783 ENOG4105CNN ABC, transporter TepiRe1_0785 ENOG4107QP6 Xylose isomerase domain protein TIM barrel TepiRe1_0786 ENOG4105E2R ROK family TepiRe1_0787 ENOG4105DZS Phenylacetate-CoA ligase TepiRe1_0793 ENOG4108Z3G 3H domain protein TepiRe1_0797 ENOG4105E1K spore germination protein TepiRe1_0799 ENOG4105DF9 Lipoate-protein, ligase TepiRe1_0800 ENOG4105KST dependent repressor TepiRe1_0802 ENOG4105CE1 Ferrous iron transport protein b TepiRe1_0803 ENOG4105DKQ ROK family TepiRe1_0804 ENOG4105DKQ ROK family TepiRe1_0805 ENOG4105D2N Aldolase TepiRe1_0806 ENOG41086CI Bifunctional phosphoglucose phosphomannose isomerase TepiRe1_0808 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TepiRe1_0809 ENOG4105C2J ABC transporter TepiRe1_0810 ENOG4108HWV )-transporter TepiRe1_0813 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) TepiRe1_0833 ENOG4105F3H Histidine kinase TepiRe1_0834 ENOG4105C6T cysteine synthase TepiRe1_0837 ENOG4105C84 Histidine ammonia-lyase TepiRe1_0838 ENOG4105CK7 Sodium proline symporter TepiRe1_0839 ENOG4105CGP Urocanate hydratase TepiRe1_0840 ENOG4105CCS Glutamate formiminotransferase TepiRe1_0841 ENOG4105CI2 imidazolone-5-propionate hydrolase TepiRe1_0842 ENOG410908R Methenyltetrahydrofolate cyclohydrolase TepiRe1_0845 ENOG4105DIB Oligopeptide-binding protein TepiRe1_0846 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TepiRe1_0847 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TepiRe1_0848 ENOG4105C3U ABC transporter TepiRe1_0849 ENOG4108JQ7 (ABC) transporter TepiRe1_0856 ENOG4107EF8 Glycosyl transferase (Group 1 TepiRe1_0871 ENOG4108V0P LemA family TepiRe1_0873 ENOG4105C22 threonyL-tRNA synthetase TepiRe1_0874 ENOG4105VEQ Cold shock protein TepiRe1_0888 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving TepiRe1_0889 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) TepiRe1_0890 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) TepiRe1_0891 ENOG41081UC Inherit from COG: Competence protein TepiRe1_0895 ENOG4105E1Q flagellar hook-associated protein TepiRe1_0896 ENOG4105DTJ flagellar hook-associated protein TepiRe1_0898 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) TepiRe1_0899 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) TepiRe1_0918 ENOG4105C3G gtp-binding protein TepiRe1_0926 ENOG4107RT6 flagellar hook-associated TepiRe1_0927 ENOG4105MQ3 flagellar protein FliS TepiRe1_0932 ENOG4105C28 cystathionine TepiRe1_0933 ENOG4105DFD Na H antiporter TepiRe1_0934 ENOG4107RVV histidinol phosphate phosphatase, hisj family TepiRe1_0936 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer TepiRe1_0939 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) TepiRe1_0945 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) TepiRe1_0964 ENOG41086D8 Transcriptional regulator TepiRe1_0968 ENOG4105MU5 relaxase mobilization nuclease domain protein TepiRe1_0977 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TepiRe1_0979 ENOG4105DA5 (ABC) transporter TepiRe1_0983 ENOG4105C5H ABC transporter TepiRe1_0991 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism TepiRe1_0994 ENOG4105DY9 regulatoR TepiRe1_1003 ENOG4105D5G Transposase TepiRe1_1016 ENOG4108N3W hemolysin secretion protein TepiRe1_1045 ENOG4108JJ8 (ABC) transporter TepiRe1_1055 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TepiRe1_1063 ENOG4105C8Y Acetylornithine aminotransferase TepiRe1_1064 ENOG4105UQX Mate efflux family protein TepiRe1_1065 ENOG41069ER domain protein TepiRe1_1066 ENOG4105DZ1 carboxypeptidase TepiRe1_1069 ENOG4108QY0 Membrane TepiRe1_1071 ENOG4105Y5S NADH ubiquinone oxidoreductase, 24 kD TepiRe1_1074 ENOG4108I5C dEAD DEAH box helicase TepiRe1_1075 ENOG4107X2U Inherit from COG: Exonuclease-like protein TepiRe1_1077 ENOG4105CVA phosphate TepiRe1_1078 ENOG4105C8U phosphate abc transporter TepiRe1_1079 ENOG4105E2Z phosphate ABC transporter (Permease TepiRe1_1080 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TepiRe1_1081 ENOG4105BZU Histidine kinase TepiRe1_1082 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) TepiRe1_1083 ENOG4108UTW Plays a role in the regulation of phosphate uptake TepiRe1_1084 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) TepiRe1_1085 ENOG4105VI0 Pts system, glucitol sorbitol-specific TepiRe1_1088 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) TepiRe1_1092 ENOG4105CJ1 ABC, transporter TepiRe1_1094 ENOG4105DFD Na H antiporter TepiRe1_1096 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) TepiRe1_1097 ENOG4105EHG Permease protein TepiRe1_1098 ENOG4108YZT Adenosylcobinamide kinase TepiRe1_1099 ENOG4105JZC GHMP kinase TepiRe1_1100 ENOG4105CIH Imidazole acetol-phosphate transaminase TepiRe1_1101 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) TepiRe1_1102 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) TepiRe1_1103 ENOG4105CVJ phosphoglycerate mutase TepiRe1_1104 ENOG41083MR nifu domain-containing protein TepiRe1_1109 ENOG4105JVQ RNA Polymerase TepiRe1_1110 ENOG4108P49 AntiSigma factor TepiRe1_1113 ENOG4105CCN Peptidase M56 TepiRe1_1115 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) TepiRe1_1116 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase TepiRe1_1117 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) TepiRe1_1120 ENOG4108IMY Transcriptional regulator TepiRe1_1130 ENOG4105CDU Replicative dna helicase TepiRe1_1133 ENOG4105KC4 UPF0296 protein TepiRe1_1134 ENOG4108UUM single-stranded DNA-binding protein TepiRe1_1144 ENOG4105IG6 Phage terminase, large subunit TepiRe1_1167 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) TepiRe1_1168 ENOG4105CY0 Metallo-Beta-Lactamase TepiRe1_1170 ENOG41066FP Small acid-soluble spore protein I TepiRe1_1171 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase TepiRe1_1172 ENOG4105CHM Aminotransferase TepiRe1_1173 ENOG4105VR9 phosphoribosylformylglycinamidine synthase TepiRe1_1174 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I TepiRe1_1175 ENOG4107QIK phosphoribosylformylglycinamidine synthase TepiRe1_1177 ENOG4105CXB phosphoribosylaminoimidazole synthetase TepiRe1_1178 ENOG4108V3E phosphoribosylglycinamide formyltransferase TepiRe1_1179 ENOG4105DC1 bifunctional purine biosynthesis protein purh TepiRe1_1180 ENOG4107QNG Phosphoribosylglycinamide synthetase TepiRe1_1181 ENOG4108RAC Rubrerythrin TepiRe1_1182 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) TepiRe1_1184 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) TepiRe1_1185 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 TepiRe1_1186 ENOG4105TQK DNA polymerase iii, delta' subunit TepiRe1_1187 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) TepiRe1_1189 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) TepiRe1_1192 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) TepiRe1_1193 ENOG4105CSA Coproporphyrinogen iii oxidase TepiRe1_1194 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) TepiRe1_1195 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) TepiRe1_1196 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ TepiRe1_1197 ENOG4105CFG Acts as a chaperone (By similarity) TepiRe1_1198 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TepiRe1_1199 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) TepiRe1_1200 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) TepiRe1_1201 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TepiRe1_1202 ENOG4107YU2 histidine triad (hIT) protein TepiRe1_1203 ENOG4105VCC 30S ribosomal protein S21 TepiRe1_1204 ENOG4105KTH gatB Yqey TepiRe1_1205 ENOG4105F7J membrane-bound serine protease TepiRe1_1206 ENOG4105DI5 UPF0365 protein TepiRe1_1208 ENOG41068P3 sporulation protein YqfC TepiRe1_1210 ENOG4105C9A Phoh family TepiRe1_1211 ENOG4105CTJ Metal Dependent Phosphohydrolase TepiRe1_1212 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) TepiRe1_1214 ENOG4108R5T secreted protein TepiRe1_1215 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) TepiRe1_1217 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) TepiRe1_1218 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) TepiRe1_1219 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein TepiRe1_1220 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) TepiRe1_1221 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TepiRe1_1223 ENOG4105EGD dinuclear metal center protein, YbgI family TepiRe1_1225 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TepiRe1_1227 ENOG410828M hemerythrin-like, metal-binding protein TepiRe1_1232 ENOG4108V6E Cell division protein mraZ TepiRe1_1233 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) TepiRe1_1234 ENOG41068JM cell division protein, FtsL TepiRe1_1235 ENOG4105CJN penicillin-binding protein TepiRe1_1236 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) TepiRe1_1237 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) TepiRe1_1238 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) TepiRe1_1239 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) TepiRe1_1240 ENOG4105CNI cell division protein FtsW TepiRe1_1241 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) TepiRe1_1242 ENOG4105DFU Cell wall formation (By similarity) TepiRe1_1243 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) TepiRe1_1246 ENOG4105K67 small basic protein TepiRe1_1247 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) TepiRe1_1248 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) TepiRe1_1250 ENOG4105FFI sigma-e processing peptidase spoiiga TepiRe1_1251 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TepiRe1_1252 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TepiRe1_1254 ENOG4105WR5 sporulation protein, YlmC YmxH family TepiRe1_1255 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) TepiRe1_1256 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) TepiRe1_1261 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) TepiRe1_1262 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase TepiRe1_1264 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) TepiRe1_1265 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 TepiRe1_1266 ENOG4105D1H recombination factor protein RarA TepiRe1_1267 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) TepiRe1_1268 ENOG4105KXX peptidase s58 dmpa TepiRe1_1278 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein TepiRe1_1279 ENOG4107RA1 nh(3)-dependent nad( ) synthetase TepiRe1_1280 ENOG4105CDY transcriptional regulatory protein TepiRe1_1282 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) TepiRe1_1283 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) TepiRe1_1284 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) TepiRe1_1285 ENOG4105JFG SpoIID LytB domain protein TepiRe1_1286 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) TepiRe1_1288 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) TepiRe1_1289 ENOG4105VIE preprotein translocase, subunit YajC TepiRe1_1291 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TepiRe1_1292 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TepiRe1_1295 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) TepiRe1_1296 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) TepiRe1_1297 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TepiRe1_1298 ENOG4105EA8 2-Nitropropane dioxygenase TepiRe1_1299 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase TepiRe1_1300 ENOG4105CHR reductase TepiRe1_1301 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) TepiRe1_1302 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TepiRe1_1303 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) TepiRe1_1304 ENOG4105MCT stage V sporulation protein S TepiRe1_1305 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) TepiRe1_1306 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) TepiRe1_1307 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) TepiRe1_1309 ENOG4105K5M 30s ribosomal protein S16 TepiRe1_1311 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) TepiRe1_1312 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) TepiRe1_1313 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) TepiRe1_1315 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TepiRe1_1316 ENOG4105VFF UPF0102 protein TepiRe1_1317 ENOG4105C0P Mg chelatase subunit ChlI TepiRe1_1318 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase TepiRe1_1319 ENOG4105C79 DNA protecting protein DprA TepiRe1_1320 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) TepiRe1_1321 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) TepiRe1_1322 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TepiRe1_1323 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) TepiRe1_1324 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) TepiRe1_1325 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) TepiRe1_1326 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) TepiRe1_1327 ENOG4108ZC9 flagellar basal-body rod protein flgc TepiRe1_1328 ENOG4105VQ0 flagellar hook-basal body complex protein fliE TepiRe1_1329 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) TepiRe1_1330 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TepiRe1_1336 ENOG410822I Flagellar hook capping protein TepiRe1_1338 ENOG4105BZE flagellar hook protein, FlgE TepiRe1_1340 ENOG4105E14 MotA TolQ exbB proton channel TepiRe1_1341 ENOG4106VK6 Flagellar motor protein TepiRe1_1343 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TepiRe1_1344 ENOG4105DD5 Flagellar motor switch protein TepiRe1_1345 ENOG4107YTP response regulator receiver protein TepiRe1_1347 ENOG4105CN7 Flagellar biosynthetic protein FliP TepiRe1_1348 ENOG4105VS8 Flagellar biosynthetic protein fliq TepiRe1_1349 ENOG4105D19 Role in flagellar biosynthesis (By similarity) TepiRe1_1350 ENOG4105D00 flagellar biosynthetic protein flhB TepiRe1_1351 ENOG4105D7B Flagellar biosynthesis protein flha TepiRe1_1352 ENOG4105FZW flagellar biosynthesis regulator FlhF TepiRe1_1355 ENOG4105CBS Chea signal transduction histidine kinase TepiRe1_1356 ENOG4108V3W Chemotaxis protein, CheW TepiRe1_1357 ENOG4107PHP CheC --inhibitor of MCP methylation TepiRe1_1358 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) TepiRe1_1359 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TepiRe1_1364 ENOG4105C02 permease TepiRe1_1365 ENOG4105CE9 30S ribosomal protein S2 TepiRe1_1366 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) TepiRe1_1367 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) TepiRe1_1368 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) TepiRe1_1370 ENOG4105KNE Phosphatidate cytidylyltransferase TepiRe1_1371 ENOG4108REF Sporulation integral membrane protein ytvi TepiRe1_1372 ENOG4105DZP Membrane-associated zinc metalloprotease TepiRe1_1373 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) TepiRe1_1374 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) TepiRe1_1376 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) TepiRe1_1377 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) TepiRe1_1378 ENOG4105CHV Transcription elongation factor NusA TepiRe1_1379 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination TepiRe1_1380 ENOG4105VHM ribosomal protein TepiRe1_1381 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) TepiRe1_1383 ENOG4105SFS phosphoesterase RecJ domain protein TepiRe1_1384 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) TepiRe1_1385 ENOG4105DTN riboflavin biosynthesis protein ribF TepiRe1_1386 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) TepiRe1_1387 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) TepiRe1_1388 ENOG4108ZJ4 polysaccharide deacetylase TepiRe1_1389 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TepiRe1_1390 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) TepiRe1_1393 ENOG4105CN5 Metallo-Beta-Lactamase TepiRe1_1394 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit TepiRe1_1396 ENOG4105CNU cell division protein FtsK TepiRe1_1398 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) TepiRe1_1400 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) TepiRe1_1401 ENOG4105CEV competence damage-inducible protein TepiRe1_1402 ENOG4105M7V 2'-5' rna ligase TepiRe1_1403 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) TepiRe1_1405 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) TepiRe1_1409 ENOG4105D48 metallophosphoesterase TepiRe1_1410 ENOG4105MCT stage V sporulation protein S TepiRe1_1411 ENOG4105DB7 PHP domain protein TepiRe1_1413 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein TepiRe1_1414 ENOG4105DQU oxidoreductase, subunit beta TepiRe1_1416 ENOG4105D82 Glutamate dehydrogenase TepiRe1_1418 ENOG4105D5P Methylmalonyl-coA mutase TepiRe1_1419 ENOG4105DJT lAO AO transport system ATPase TepiRe1_1420 ENOG4108ZVT methylmalonyl-coA epimerase TepiRe1_1421 ENOG4108HNZ carboxyl transferase TepiRe1_1423 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein TepiRe1_1424 ENOG4105D9Q decarboxylase (Beta subunit) TepiRe1_1425 ENOG4107QSA Oxaloacetate decarboxylase TepiRe1_1427 ENOG41073R8 VanW family TepiRe1_1430 ENOG4108UN4 phage SPO1 DNA polymerase-related protein TepiRe1_1431 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TepiRe1_1432 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) TepiRe1_1433 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) TepiRe1_1434 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) TepiRe1_1435 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) TepiRe1_1436 ENOG4106F1P AAA ATPase, central domain protein TepiRe1_1437 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control TepiRe1_1440 ENOG4105CXI aluminum resistance protein TepiRe1_1441 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) TepiRe1_1444 ENOG4105YAC TepiRe1_1445 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) TepiRe1_1448 ENOG4105CN9 Peptidase m42 family protein TepiRe1_1449 ENOG4105CN9 Peptidase m42 family protein TepiRe1_1450 ENOG4105CN9 Peptidase m42 family protein TepiRe1_1451 ENOG4105BZU Histidine kinase TepiRe1_1452 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) TepiRe1_1453 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) TepiRe1_1454 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) TepiRe1_1457 ENOG4105CBX hi0933 family TepiRe1_1459 ENOG4105E0A ABC, transporter TepiRe1_1461 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) TepiRe1_1463 ENOG4105FE9 pseudouridine synthase TepiRe1_1466 ENOG4107CHF 5,6-aminomutase beta subunit TepiRe1_1469 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) TepiRe1_1470 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) TepiRe1_1473 ENOG4105KBJ sporulation protein ytfj TepiRe1_1476 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) TepiRe1_1477 ENOG4105C31 Tryptophanyl-tRNA synthetase TepiRe1_1478 ENOG4108Z4T Peptidase M50 TepiRe1_1479 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) TepiRe1_1480 ENOG4105CIZ coA-substrate-specific enzyme activase TepiRe1_1485 ENOG4105CZ3 stage V sporulation protein ad TepiRe1_1486 ENOG41090VF Stage v sporulation protein ac TepiRe1_1487 ENOG41084UG Pfam:DUF1458 TepiRe1_1488 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TepiRe1_1489 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) TepiRe1_1490 ENOG41082AN stage II sporulation protein TepiRe1_1491 ENOG4105DZ1 carboxypeptidase TepiRe1_1492 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TepiRe1_1493 ENOG4105MZ9 stage II sporulation protein m TepiRe1_1496 ENOG4107QQR Sporulation TepiRe1_1497 ENOG4105S1Z Stage IV sporulation protein B TepiRe1_1498 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) TepiRe1_1499 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) TepiRe1_1500 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) TepiRe1_1502 ENOG4105DX0 Hemolysin A TepiRe1_1506 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) TepiRe1_1507 ENOG4105M7K Involved in the transcription termination process (By similarity) TepiRe1_1510 ENOG4105VBF alkaline shock protein TepiRe1_1515 ENOG4105KQ4 Stage iii sporulation protein ad TepiRe1_1516 ENOG4108CQH stage III sporulation protein AC TepiRe1_1518 ENOG4105CD2 stage iii sporulation protein aa TepiRe1_1520 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) TepiRe1_1521 ENOG4105DC7 peptidase M24 TepiRe1_1531 ENOG4107QHF type ii secretion system protein e TepiRe1_1532 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase TepiRe1_1533 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TepiRe1_1534 ENOG4105CJN penicillin-binding protein TepiRe1_1535 ENOG4105HHA aminodeoxychorismate lyase TepiRe1_1538 ENOG4105I3K Ferric uptake regulator, Fur family TepiRe1_1540 ENOG41085AS UPF0473 protein TepiRe1_1541 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) TepiRe1_1542 ENOG4107SET aldo keto reductase TepiRe1_1543 ENOG4105VBH UPF0297 protein TepiRe1_1544 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) TepiRe1_1546 ENOG4105CUZ uba thif-type nad fad binding protein TepiRe1_1547 ENOG4105C9M aspartyl-trna synthetase TepiRe1_1548 ENOG4105C0H protease TepiRe1_1550 ENOG4105C5X domain protein TepiRe1_1551 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) TepiRe1_1552 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) TepiRe1_1553 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) TepiRe1_1554 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) TepiRe1_1559 ENOG4108IJ2 phosphate acetyltransferase TepiRe1_1561 ENOG41063PX domain protein TepiRe1_1563 ENOG4105H20 Sporulation integral membrane protein YlbJ TepiRe1_1565 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) TepiRe1_1566 ENOG4106H78 methyltransferase TepiRe1_1569 ENOG4105DP4 dak2 domain fusion protein ylov TepiRe1_1570 ENOG4108ZAA Alkaline-shock protein TepiRe1_1573 ENOG4105DJV ribulose-phosphate 3-epimerase TepiRe1_1574 ENOG4105D9P serine threonine protein kinase TepiRe1_1575 ENOG4108ZF3 Phosphatase TepiRe1_1576 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs TepiRe1_1577 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B TepiRe1_1579 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) TepiRe1_1580 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TepiRe1_1581 ENOG4105C25 Primosomal protein n' TepiRe1_1582 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase TepiRe1_1583 ENOG41084KE Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) TepiRe1_1584 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) TepiRe1_1586 ENOG4105DSJ YicC domain protein TepiRe1_1588 ENOG4105F23 Fibronectin-binding protein TepiRe1_1589 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) TepiRe1_1590 ENOG4105C34 Pseudouridine synthase TepiRe1_1591 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) TepiRe1_1592 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters TepiRe1_1596 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) TepiRe1_1597 ENOG4105DFA alanine racemase domain protein TepiRe1_1600 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) TepiRe1_1601 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) TepiRe1_1603 ENOG41090I5 UPF0735 ACT domain-containing protein TepiRe1_1605 ENOG4105CSM endonuclease III TepiRe1_1606 ENOG4105CN1 protease TepiRe1_1609 ENOG4105C19 ABC transporter TepiRe1_1611 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TepiRe1_1614 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) TepiRe1_1615 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) TepiRe1_1617 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein TepiRe1_1619 ENOG4105DIW FeS assembly protein SUFB TepiRe1_1620 ENOG4108IUZ ABC transporter TepiRe1_1622 ENOG4105C8T Leucyl-tRNA synthetase TepiRe1_1624 ENOG4108KGH TRANSCRIPTIONal TepiRe1_1625 ENOG4108WF2 Metal Dependent Phosphohydrolase TepiRe1_1626 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) TepiRe1_1627 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control TepiRe1_1630 ENOG4105K46 50S ribosomal protein l27 TepiRe1_1631 ENOG4105X36 (ribosomal) protein TepiRe1_1634 ENOG4105MSI germination protein ypeb TepiRe1_1640 ENOG4105C03 ribonuclease TepiRe1_1645 ENOG4105CNI cell division protein FtsW TepiRe1_1646 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) TepiRe1_1647 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) TepiRe1_1648 ENOG4107QMS site-determining protein TepiRe1_1649 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) TepiRe1_1650 ENOG4105CJN penicillin-binding protein TepiRe1_1652 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) TepiRe1_1653 ENOG4105DFF Rod shape-determining protein mreb TepiRe1_1654 ENOG4105W5Q DNA repair protein (RadC TepiRe1_1655 ENOG4108Z03 MAF-like protein TepiRe1_1659 ENOG4105EMN RNA polymerase sigma factor TepiRe1_1668 ENOG4105CPQ Dehydrogenase TepiRe1_1673 ENOG4105C6Z Gluconate TepiRe1_1678 ENOG4107S2N Type III effector Hrp-dependent TepiRe1_1679 ENOG4108JUB Transcriptional regulator TepiRe1_1682 ENOG4105C8Q Methyl-accepting chemotaxis TepiRe1_1684 ENOG4108JIC nucleoside recognition domain protein TepiRe1_1685 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) TepiRe1_1687 ENOG4105DCF alanine dehydrogenase TepiRe1_1689 ENOG4105BZU Histidine kinase TepiRe1_1690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TepiRe1_1694 ENOG4105EAM Na Pi-cotransporter TepiRe1_1695 ENOG4105EAM Na Pi-cotransporter TepiRe1_1699 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TepiRe1_1700 ENOG4105C7J ABC transporter, permease TepiRe1_1702 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TepiRe1_1704 ENOG4105CTX dehydratase TepiRe1_1705 ENOG4107QZW Altronate oxidoreductase TepiRe1_1706 ENOG4105DH8 myo-inositol catabolism TepiRe1_1708 ENOG4105CG6 trap dicarboxylate transporter dctm subunit TepiRe1_1710 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit TepiRe1_1714 ENOG4105MWK D-amino acid dehydrogenase, small subunit TepiRe1_1715 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein TepiRe1_1719 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) TepiRe1_1723 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) TepiRe1_1731 ENOG4105DEF Extracellular solute-binding protein, family 5 TepiRe1_1733 ENOG4108VMM UPF0756 membrane protein TepiRe1_1734 ENOG4105E4C Lytic transglycosylase catalytic TepiRe1_1735 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) TepiRe1_1738 ENOG4105EMN RNA polymerase sigma factor TepiRe1_1739 ENOG4108IV0 ABC, transporter TepiRe1_1740 ENOG4105C0Z ABC transporter TepiRe1_1741 ENOG4105CF8 branched-chain amino acid ABC transporter, permease TepiRe1_1742 ENOG4105C32 Amino acid ABC transporter (Permease) TepiRe1_1743 ENOG4105CP9 extracellular ligand-binding receptor TepiRe1_1744 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) TepiRe1_1745 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) TepiRe1_1746 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) TepiRe1_1748 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase TepiRe1_1749 ENOG4105DK0 Indole-3-glycerol phosphate synthase TepiRe1_1751 ENOG4105DDQ anthranilate synthase TepiRe1_1752 ENOG4105CRQ synthase (Component I) TepiRe1_1754 ENOG4105CS2 ec 3.2.1.21 TepiRe1_1755 ENOG4105CAH Chromate TepiRe1_1756 ENOG4105CAH Chromate TepiRe1_1757 ENOG4105E2R ROK family TepiRe1_1758 ENOG4105C4X radical SAM domain protein TepiRe1_1760 ENOG4105CK1 PTS System TepiRe1_1762 ENOG4105VCP PTS System TepiRe1_1767 ENOG4105CK1 PTS System TepiRe1_1769 ENOG4105VCP PTS System TepiRe1_1770 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TepiRe1_1771 ENOG4105C8Q Methyl-accepting chemotaxis TepiRe1_1773 ENOG4105F0V Cell wall hydrolase TepiRe1_1774 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) TepiRe1_1775 ENOG41076HS cation diffusion facilitator family transporter TepiRe1_1777 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TepiRe1_1778 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) TepiRe1_1781 ENOG4105C0H protease TepiRe1_1782 ENOG4105CN1 protease TepiRe1_1783 ENOG4105E4C Lytic transglycosylase catalytic TepiRe1_1784 ENOG4105CRP Part of the ABC transporter FtsEX involved in TepiRe1_1785 ENOG4105CAK Cell division ATP-binding protein ftsE TepiRe1_1787 ENOG4105C8J )-transporter TepiRe1_1788 ENOG4105CKB glycosidase TepiRe1_1797 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) TepiRe1_1798 ENOG4108HHA Transketolase TepiRe1_1802 ENOG4105CPK Glycosyl transferase (Group 1 TepiRe1_1807 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) TepiRe1_1810 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase TepiRe1_1812 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) TepiRe1_1813 ENOG4105D2N Aldolase TepiRe1_1816 ENOG4105S7A ErfK ybiS ycfS ynhG family protein TepiRe1_1817 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) TepiRe1_1818 ENOG4105C8M UPF0272 protein TepiRe1_1819 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase TepiRe1_1821 ENOG4105C7H Helicase, RecD TraA family TepiRe1_1823 ENOG4105BZU Histidine kinase TepiRe1_1825 ENOG4105C87 Aminotransferase class I and II TepiRe1_1826 ENOG4108IQ3 PTS system TepiRe1_1828 ENOG4105F3R pts system mannose fructose sorbose family iid TepiRe1_1829 ENOG4105C5R Aminotransferase TepiRe1_1831 ENOG4108IQ3 PTS system TepiRe1_1832 ENOG4108EQA pts system TepiRe1_1833 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TepiRe1_1836 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP TepiRe1_1839 ENOG4107NFR Fructose-1,6-bisphosphatase TepiRe1_1847 ENOG4105MZU cell filamentation protein TepiRe1_1855 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) TepiRe1_1856 ENOG4107RBB ABC transporter, permease TepiRe1_1857 ENOG4105C19 ABC transporter TepiRe1_1861 ENOG4105DVE abc transporter atp-binding protein TepiRe1_1862 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family TepiRe1_1863 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate TepiRe1_1867 ENOG4105ETZ PTS System TepiRe1_1870 ENOG4106KNT transcriptional regulator TepiRe1_1871 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) TepiRe1_1872 ENOG4105W8H transhydrogenase (subunit alpha TepiRe1_1873 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) TepiRe1_1874 ENOG4108JUB Transcriptional regulator TepiRe1_1875 ENOG4105CI1 PTS System TepiRe1_1877 ENOG4105CI1 PTS System TepiRe1_1878 ENOG4108WYP Transcriptional regulator TepiRe1_1879 ENOG4105DH8 myo-inositol catabolism TepiRe1_1881 ENOG4105CPQ Dehydrogenase TepiRe1_1883 ENOG4108IV0 ABC, transporter TepiRe1_1884 ENOG4105C0Z ABC transporter TepiRe1_1885 ENOG4105CF8 branched-chain amino acid ABC transporter, permease TepiRe1_1886 ENOG4105C32 Amino acid ABC transporter (Permease) TepiRe1_1887 ENOG4105CP9 extracellular ligand-binding receptor TepiRe1_1888 ENOG41061TZ Short-chain dehydrogenase reductase Sdr TepiRe1_1889 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) TepiRe1_1891 ENOG4105CMG Carbohydrate kinase TepiRe1_1892 ENOG4108JQ1 Dehydrogenase TepiRe1_1893 ENOG4105DEI Mannitol dehydrogenase TepiRe1_1894 ENOG4105BZU Histidine kinase TepiRe1_1897 ENOG4105CJR Integral membrane protein (MviN TepiRe1_1903 ENOG4108KMV Glycosyl transferase (Group 1 TepiRe1_1909 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TepiRe1_1910 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) TepiRe1_1913 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TepiRe1_1915 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TepiRe1_1916 ENOG4105D3Q Sugar transferase TepiRe1_1926 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TepiRe1_1927 ENOG4108Z5K methylglyoxal synthase TepiRe1_1929 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TepiRe1_1930 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TepiRe1_1931 ENOG4105ENT Efflux transporter rnd family, mfp subunit TepiRe1_1932 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) TepiRe1_1935 ENOG4107BJW polysaccharide deacetylase TepiRe1_1941 ENOG4108RVA ribokinase TepiRe1_1942 ENOG4105C2X Arabinose 5-phosphate isomerase TepiRe1_1943 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TepiRe1_1944 ENOG4105C6K Malic enzyme TepiRe1_1947 ENOG4105ERH Fumarylacetoacetate hydrolase TepiRe1_1948 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TepiRe1_1949 ENOG4105DG4 malate L-lactate dehydrogenase TepiRe1_1950 ENOG4108IV0 ABC, transporter TepiRe1_1951 ENOG4105C0Z ABC transporter TepiRe1_1952 ENOG4105CF8 branched-chain amino acid ABC transporter, permease TepiRe1_1953 ENOG4105C32 Amino acid ABC transporter (Permease) TepiRe1_1955 ENOG4105ETE Transcriptional regulator (LacI family TepiRe1_1957 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TepiRe1_1960 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TepiRe1_1962 ENOG4108IYU L-aspartate oxidase TepiRe1_1965 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) TepiRe1_1966 ENOG4105E39 Enoyl-CoA hydratase TepiRe1_1967 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) TepiRe1_1968 ENOG4108Z7G MaoC domain protein dehydratase TepiRe1_1969 ENOG4107Y0V Not clear, may be involved in an isomerization step TepiRe1_1970 ENOG4105CG6 trap dicarboxylate transporter dctm subunit TepiRe1_1971 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter TepiRe1_1972 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit TepiRe1_1973 ENOG4105E2X shikimate dehydrogenase TepiRe1_1977 ENOG4108RTU Aldolase TepiRe1_1978 ENOG410688J Ferredoxin TepiRe1_1979 ENOG4108HWV )-transporter TepiRe1_1980 ENOG4105C2J ABC transporter TepiRe1_1981 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TepiRe1_1982 ENOG4105DFW ABC transporter TepiRe1_1983 ENOG4108VAC response regulator TepiRe1_1984 ENOG4108HRK Histidine kinase TepiRe1_1989 ENOG4105C8Q Methyl-accepting chemotaxis TepiRe1_1991 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) TepiRe1_1992 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) TepiRe1_1993 ENOG4108R6K riboflavin synthase, subunit alpha TepiRe1_1994 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) TepiRe1_1995 ENOG4105VI0 Pts system, glucitol sorbitol-specific TepiRe1_1998 ENOG4105DZY Pts system, glucitol sorbitol-specific TepiRe1_1999 ENOG410787A Pts system, glucitol sorbitol-specific TepiRe1_2001 ENOG4107QN1 sodium solute TepiRe1_2005 ENOG4107RCH Diaminopropionate ammonia-lyase TepiRe1_2006 ENOG4108JUB Transcriptional regulator TepiRe1_2007 ENOG4105CK1 PTS System TepiRe1_2009 ENOG4105VCP PTS System TepiRe1_2011 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TepiRe1_2020 ENOG4105DFD Na H antiporter TepiRe1_2021 ENOG4105C0F tryptophanase EC 4.1.99.1 TepiRe1_2025 ENOG4105WEF catalase TepiRe1_2026 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit TepiRe1_2028 ENOG4105DZB Electron transport complex TepiRe1_2029 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit TepiRe1_2030 ENOG4105D6A Electron transport complex TepiRe1_2031 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) TepiRe1_2032 ENOG4105TMB Formate nitrite transporter TepiRe1_2033 ENOG4107QHI -hydrogenase TepiRe1_2034 ENOG4107QIZ NADH dehydrogenase TepiRe1_2036 ENOG4105BZU Histidine kinase TepiRe1_2037 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit TepiRe1_2041 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase TepiRe1_2042 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) TepiRe1_2045 ENOG4108JQ7 (ABC) transporter TepiRe1_2046 ENOG4105C3U ABC transporter TepiRe1_2047 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TepiRe1_2048 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TepiRe1_2049 ENOG4105DEF Extracellular solute-binding protein, family 5 TepiRe1_2051 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) TepiRe1_2052 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) TepiRe1_2053 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) TepiRe1_2058 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family TepiRe1_2060 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate TepiRe1_2062 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase TepiRe1_2069 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) TepiRe1_2071 ENOG4105C28 cystathionine TepiRe1_2073 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) TepiRe1_2074 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) TepiRe1_2075 ENOG4105CUT histidyl-tRNA synthetase TepiRe1_2079 ENOG4107R8N Glycosyl transferase, family 2 TepiRe1_2082 ENOG4105CM2 brancheD-chain amino acid aminotransferase TepiRe1_2083 ENOG4105C7K acetolactate synthase TepiRe1_2084 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) TepiRe1_2085 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TepiRe1_2086 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TepiRe1_2087 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) TepiRe1_2088 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase TepiRe1_2090 ENOG4105C7K acetolactate synthase TepiRe1_2097 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) TepiRe1_2098 ENOG4105CH2 amidohydrolase TepiRe1_2099 ENOG4107XCH Cyclase family TepiRe1_2101 ENOG4105C01 Dihydroxy-acid dehydratase TepiRe1_2102 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase TepiRe1_2103 ENOG4105JXH GntR family transcriptional regulator TepiRe1_2104 ENOG4108IUS Transketolase TepiRe1_2105 ENOG4108HHA Transketolase TepiRe1_2109 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit TepiRe1_2114 ENOG4105C2F Histidine kinase TepiRe1_2116 ENOG4105CDA abc transporter atp-binding protein TepiRe1_2117 ENOG4105E5Q amino acid AbC transporter TepiRe1_2119 ENOG4105CT1 (ABC) transporter TepiRe1_2120 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for TepiRe1_2123 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation TepiRe1_2124 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination TepiRe1_2125 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) TepiRe1_2127 ENOG4105CP7 Triose-phosphate isomerase TepiRe1_2128 ENOG4105BZA Phosphoglycerate kinase TepiRe1_2131 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TepiRe1_2137 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) TepiRe1_2139 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) TepiRe1_2140 ENOG4108Z0R Transferase TepiRe1_2143 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) TepiRe1_2144 ENOG4105EPR degv family TepiRe1_2146 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) TepiRe1_2148 ENOG4105KG3 cytidine deaminase TepiRe1_2149 ENOG4105FDP GntR family transcriptional regulator TepiRe1_2152 ENOG4105UIB (ABC) transporter TepiRe1_2153 ENOG4108JQ9 ABC transporter TepiRe1_2154 ENOG4105DIH basic membrane TepiRe1_2158 ENOG4105DGA Diaminopimelate dehydrogenase TepiRe1_2161 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism TepiRe1_2163 ENOG4105DY9 regulatoR TepiRe1_2167 ENOG4108UIC UPF0340 protein TepiRe1_2168 ENOG4105C0D helicase TepiRe1_2169 ENOG4107XWB Zinc finger, swim domain protein TepiRe1_2170 ENOG4106N3A copper homeostasis protein cutc TepiRe1_2171 ENOG4108SU4 UPF0309 protein TepiRe1_2174 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC TepiRe1_2176 ENOG4106ETB IIa component TepiRe1_2177 ENOG4105QUH Domain of unknown function (DUF2088) TepiRe1_2180 ENOG4105C87 Aminotransferase class I and II TepiRe1_2181 ENOG4108Z0Z intracellular protease Pfpi family TepiRe1_2183 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) TepiRe1_2184 ENOG4108626 Racemase TepiRe1_2185 ENOG4106PKC pyridoxal phosphate binding TepiRe1_2186 ENOG41080QX K07048 phosphotriesterase-related protein TepiRe1_2187 ENOG4106M0N transport system permease protein TepiRe1_2188 ENOG4105MUZ Protein of unknown function DUF2620 TepiRe1_2190 ENOG4108M21 TepiRe1_2191 ENOG4105J7I hydrolase TepiRe1_2193 ENOG4108IGT Dipeptidase TepiRe1_2194 ENOG4108UT2 hemolysin iii TepiRe1_2197 ENOG4105CIH Imidazole acetol-phosphate transaminase TepiRe1_2198 ENOG4105DFD Na H antiporter TepiRe1_2199 ENOG41062D9 Histidine kinase TepiRe1_2200 ENOG4105XJC Two component transcriptional regulator (Winged helix family TepiRe1_2204 ENOG4105KTW ethanolamine utilization protein TepiRe1_2205 ENOG4105M3W utilization protein TepiRe1_2208 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) TepiRe1_2210 ENOG4108FN7 Aldo keto reductase TepiRe1_2211 ENOG4105CNN ABC, transporter TepiRe1_2212 ENOG4105C2J ABC transporter TepiRe1_2213 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TepiRe1_2216 ENOG4105CJ3 phosphate transporter TepiRe1_2217 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) TepiRe1_2222 ENOG41067VP Protein of unknown function (DUF1049) TepiRe1_2223 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) TepiRe1_2224 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj TepiRe1_2225 ENOG4105CGA flagellar basal-body rod protein FlgG TepiRe1_2227 ENOG4105DFF Rod shape-determining protein mreb TepiRe1_2228 ENOG4105MT0 Sporulation transcriptional regulator spoiiid TepiRe1_2229 ENOG4108K5P (LipO)protein TepiRe1_2231 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) TepiRe1_2235 ENOG4105M56 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) TepiRe1_2238 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) TepiRe1_2239 ENOG4105KXQ Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) TepiRe1_2241 ENOG4105QD4 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) TepiRe1_2247 ENOG4105WJF TepiRe1_2248 ENOG4108JCD RNA Polymerase TepiRe1_2249 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase TepiRe1_2250 ENOG4105ESV Glycosyl transferase, family 4 TepiRe1_2252 ENOG4108HHA Transketolase TepiRe1_2256 ENOG4105XN3 extracellular solute-binding protein family 1 TepiRe1_2257 ENOG4107EJG GntR family transcriptional regulator TepiRe1_2263 ENOG4108UK2 deaminase TepiRe1_2267 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) TepiRe1_2269 ENOG4107YBY Hydrolase TepiRe1_2271 ENOG4105CK5 oxidoreductase TepiRe1_2272 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) TepiRe1_2273 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) TepiRe1_2274 ENOG4108YZG isomerase TepiRe1_2276 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TepiRe1_2278 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) TepiRe1_2279 ENOG4105CBJ Metal-dependent enzyme TepiRe1_2280 ENOG41082DI 50s ribosomal protein l31 TepiRe1_2284 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) TepiRe1_2286 ENOG4105CPI Metal Dependent Phosphohydrolase TepiRe1_2287 ENOG4105NBF ammecr1 domain protein TepiRe1_2293 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) TepiRe1_2294 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) TepiRe1_2298 ENOG4108UGV hypoxanthine phosphoribosyltransferase TepiRe1_2301 ENOG4105C8Q Methyl-accepting chemotaxis TepiRe1_2303 ENOG4105C6Z Gluconate TepiRe1_2304 ENOG4105BZW Glycerate kinase TepiRe1_2305 ENOG4105CMG Carbohydrate kinase TepiRe1_2306 ENOG4105C6Z Gluconate TepiRe1_2307 ENOG4105D2N Aldolase TepiRe1_2308 ENOG4108JQ1 Dehydrogenase TepiRe1_2309 ENOG4106KNT transcriptional regulator TepiRe1_2310 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) TepiRe1_2311 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit TepiRe1_2313 ENOG4105CHR reductase TepiRe1_2315 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) TepiRe1_2320 ENOG4106J7S Glycosyl transferase, family 2 TepiRe1_2322 ENOG4107Y70 Heat shock protein TepiRe1_2324 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) TepiRe1_2325 ENOG4108VZM 50s ribosomal protein L10 TepiRe1_2327 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) TepiRe1_2328 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) TepiRe1_2329 ENOG410683Z Preprotein translocase SecE subunit TepiRe1_2330 ENOG4105WDJ 50S ribosomal protein L33 TepiRe1_2334 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) TepiRe1_2335 ENOG4105QIV RNA polymerase TepiRe1_2336 ENOG4105M0M Tetracycline resistance protein TepiRe1_2337 ENOG4105C2N RNA methyltransferase TrmH family group 3 TepiRe1_2339 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) TepiRe1_2340 ENOG4105C8N cysteinyl-tRNA synthetase TepiRe1_2341 ENOG4105D7W serine acetyltransferase TepiRe1_2342 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) TepiRe1_2343 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) TepiRe1_2344 ENOG4105CTP PilT protein domain protein TepiRe1_2345 ENOG4108VJ1 Transcriptional regulator (CarD family TepiRe1_2347 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) TepiRe1_2348 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TepiRe1_2349 ENOG41066A3 ATP guanido phosphotransferase TepiRe1_2350 ENOG4108Z0C Uvrb UvrC protein TepiRe1_2353 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TepiRe1_2354 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) TepiRe1_2356 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TepiRe1_2357 ENOG4105VZJ PTS System TepiRe1_2358 ENOG4105CK1 PTS System TepiRe1_2361 ENOG4105F8D glycoside hydrolase family 4 TepiRe1_2362 ENOG4107104 thymidine kinase TepiRe1_2367 ENOG4105D78 K07001 NTE family protein TepiRe1_2368 ENOG4105DDK oxidoreductase, beta subunit TepiRe1_2369 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) TepiRe1_2370 ENOG4105WGB oxidoreductase, delta subunit TepiRe1_2371 ENOG4105EJ5 oxidoreductase gamma subunit TepiRe1_2378 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate TepiRe1_2380 ENOG4105CMG Carbohydrate kinase TepiRe1_2381 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) TepiRe1_2386 ENOG4108YZG isomerase TepiRe1_2387 ENOG4105N2W Transcriptional regulator TepiRe1_2388 ENOG4108UTZ Dihydroxyacetone kinase TepiRe1_2389 ENOG4105CMT Dihydroxyacetone kinase TepiRe1_2390 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) TepiRe1_2393 ENOG4105CVR type I restriction-modification system TepiRe1_2394 ENOG4105F27 Major Facilitator TepiRe1_2403 ENOG4108WS4 fmn reductase TepiRe1_2407 ENOG4105CJ1 ABC, transporter TepiRe1_2408 ENOG41082YX Transcriptional regulator, arsr family TepiRe1_2410 ENOG4105BZU Histidine kinase TepiRe1_2412 ENOG4105VCP PTS System TepiRe1_2415 ENOG4107QSE Dipeptidase TepiRe1_2417 ENOG4105CK1 PTS System TepiRe1_2420 ENOG4105ETD TRANSCRIPTIONal TepiRe1_2421 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase TepiRe1_2422 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) TepiRe1_2423 ENOG4105EEI dihydropteroate synthase TepiRe1_2424 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase TepiRe1_2425 ENOG4105CS2 ec 3.2.1.21 TepiRe1_2426 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase TepiRe1_2427 ENOG4105CK1 PTS System TepiRe1_2442 ENOG4105QUH Domain of unknown function (DUF2088) TepiRe1_2443 ENOG4105CHY citrate lyase, alpha TepiRe1_2445 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) TepiRe1_2446 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TepiRe1_2447 ENOG4107QM5 aconitate hydratase TepiRe1_2450 ENOG4105C7F AcnD-accessory protein PrpF TepiRe1_2452 ENOG4108KB2 LysR family Transcriptional regulator TepiRe1_2454 ENOG4105DUA (citrate (pro-3S)-lyase ligase TepiRe1_2459 ENOG4108UXE Protein tyrosine phosphatase TepiRe1_2462 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TepiRe1_2463 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TepiRe1_2464 ENOG4105C6Z Gluconate TepiRe1_2465 ENOG4108JUB Transcriptional regulator TepiRe1_2510 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) TepiRe1_2511 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) TepiRe1_2512 ENOG4105C6E dna polymerase iii TepiRe1_2513 ENOG4108Z6B deaminase TepiRe1_2514 ENOG4108Z7F N-acetyltransferase TepiRe1_2515 ENOG4108ZJ4 polysaccharide deacetylase TepiRe1_2516 ENOG4105W7A Protein of unknown function (DUF503) TepiRe1_2517 ENOG4105E5Q amino acid AbC transporter TepiRe1_2519 ENOG4105E5Q amino acid AbC transporter TepiRe1_2520 ENOG4105CIF Ornithine Cyclodeaminase TepiRe1_2521 ENOG4106TNF Periplasmic binding protein TepiRe1_2523 ENOG4105C8J )-transporter TepiRe1_2524 ENOG4105C0F tryptophanase EC 4.1.99.1 TepiRe1_2525 ENOG4108JUB Transcriptional regulator TepiRe1_2530 ENOG4105C6F GntR Family Transcriptional Regulator TepiRe1_2532 ENOG4105BZJ Electron transfer flavoprotein TepiRe1_2533 ENOG4105C10 Electron transfer flavoprotein TepiRe1_2534 ENOG4105CQB FAD linked oxidase domain protein TepiRe1_2537 ENOG4105JVQ RNA Polymerase TepiRe1_2539 ENOG4108HQS Glycine betaine TepiRe1_2543 ENOG4108ZJ4 polysaccharide deacetylase TepiRe1_2545 ENOG4107QHQ amino acid TepiRe1_2546 ENOG4105C87 Aminotransferase class I and II TepiRe1_2548 ENOG4107VRI Transcriptional regulator TepiRe1_2550 ENOG4105C8Q Methyl-accepting chemotaxis TepiRe1_2556 ENOG4105NA0 Transcriptional regulator TepiRe1_2583 ENOG4105DNE Transposase TepiRe1_2585 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TepiRe1_2586 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase TepiRe1_2587 ENOG4105XSJ toxin secretion phage lysis holin TepiRe1_2604 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TepiRe1_2606 ENOG4105CAR Terminase, large subunit TepiRe1_2614 ENOG4105VXN addiction module toxin, RelE StbE family TepiRe1_2622 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) TepiRe1_2626 ENOG4105C2M dna polymerase I TepiRe1_2639 ENOG4105ZU5 s-layer protein TepiRe1_2641 ENOG4105DAN ATP-dependent protease TepiRe1_2642 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) TepiRe1_2643 ENOG4108NVR Methyl-accepting chemotaxis TepiRe1_2644 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) TepiRe1_2645 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein TepiRe1_2647 ENOG4105C75 arginyL-tRNA synthetase TepiRe1_2649 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) TepiRe1_2650 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) TepiRe1_2651 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) TepiRe1_2652 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) TepiRe1_2654 ENOG4105CD3 dihydroorotase TepiRe1_2655 ENOG4105CXT aspartate transcarbamylase TepiRe1_2658 ENOG4105CQC Prephenate dehydratase TepiRe1_2659 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase TepiRe1_2661 ENOG4105D49 3-dehydroquinate synthase TepiRe1_2662 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase TepiRe1_2663 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase TepiRe1_2665 ENOG4105E2X shikimate dehydrogenase TepiRe1_2666 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) TepiRe1_2667 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) TepiRe1_2668 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) TepiRe1_2670 ENOG4105F0V Cell wall hydrolase TepiRe1_2671 ENOG4105XEW small acid-soluble spore protein TepiRe1_2672 ENOG4105CXN decarboxylase TepiRe1_2673 ENOG4108ZXQ stage ii sporulation protein r TepiRe1_2677 ENOG4105VUC UPF0237 protein TepiRe1_2685 ENOG4105CAH Chromate TepiRe1_2686 ENOG4105CAH Chromate TepiRe1_2688 ENOG4105CSV Glutaminase TepiRe1_2692 ENOG4107QJQ Mate efflux family protein TepiRe1_2693 ENOG4108MCI Transcriptional regulator, ARAC family TepiRe1_2697 ENOG4105C9U ATP-dependent DNA helicase RecQ TepiRe1_2699 ENOG4107QHI -hydrogenase TepiRe1_2700 ENOG4107QIZ NADH dehydrogenase TepiRe1_2701 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit TepiRe1_2708 ENOG4105CIG ABC transporter TepiRe1_2712 ENOG4107R8N Glycosyl transferase, family 2 TepiRe1_2716 ENOG4105C01 Dihydroxy-acid dehydratase TepiRe1_2720 ENOG4106A3R peptidase TepiRe1_2721 ENOG4108VAU general secretion pathway protein G TepiRe1_2723 ENOG4107YTP response regulator receiver protein TepiRe1_2725 ENOG4105WH1 Two component transcriptional regulator luxr family TepiRe1_2726 ENOG4107R88 Chemotaxis protein (CheV) TepiRe1_2729 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TepiRe1_2730 ENOG4105DRR Transcriptional regulator, GntR family TepiRe1_2731 ENOG4105C8Q Methyl-accepting chemotaxis TepiRe1_2732 ENOG4105BZU Histidine kinase TepiRe1_2733 ENOG4105CPI Metal Dependent Phosphohydrolase TepiRe1_2734 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TepiRe1_2735 ENOG4108EQA pts system TepiRe1_2736 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB TepiRe1_2737 ENOG4105ETZ PTS System TepiRe1_2738 ENOG4105F3R pts system mannose fructose sorbose family iid TepiRe1_2739 ENOG4105CPQ Dehydrogenase TepiRe1_2742 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase TepiRe1_2743 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TepiRe1_2744 ENOG4105C8Q Methyl-accepting chemotaxis TepiRe1_2746 ENOG4105CEM UPF0597 protein TepiRe1_2747 ENOG4108JUB Transcriptional regulator TepiRe1_2749 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) TepiRe1_2750 ENOG4105EPR degv family TepiRe1_2753 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) TepiRe1_2756 ENOG4107S52 alpha-2-macroglobulin domain protein TepiRe1_2759 ENOG4107XJU UPF0178 protein TepiRe1_2763 ENOG4105DIN metallophosphoesterase TepiRe1_2765 ENOG4105CGK Exodeoxyribonuclease III TepiRe1_2769 ENOG4105VFE sira family TepiRe1_2770 ENOG41066VF YeeE YedE family protein TepiRe1_2775 ENOG4105DM4 PTS System TepiRe1_2776 ENOG4105DM4 PTS System TepiRe1_2777 ENOG4105DE4 1-phosphofructokinase TepiRe1_2778 ENOG4105E98 transcriptional regulator DeoR family TepiRe1_2779 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) TepiRe1_2782 ENOG4105IJJ transcriptional regulator, crp fnr family TepiRe1_2789 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) TepiRe1_2798 ENOG4105C3R Methionine synthase TepiRe1_2800 ENOG4105E5Q amino acid AbC transporter TepiRe1_2801 ENOG4106TNF Periplasmic binding protein TepiRe1_2803 ENOG4105C0H protease TepiRe1_2808 ENOG4105BZU Histidine kinase TepiRe1_2809 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TepiRe1_2814 ENOG41061JJ Peptidase family M23 TepiRe1_2817 ENOG4105DZ0 fad dependent oxidoreductase TepiRe1_2820 ENOG4105CDU Replicative dna helicase TepiRe1_2821 ENOG4105K9Q Binds to the 23S rRNA (By similarity) TepiRe1_2822 ENOG4105BZR domain protein TepiRe1_2823 ENOG4108XMW Membrane TepiRe1_2824 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) TepiRe1_2825 ENOG4108UUM single-stranded DNA-binding protein TepiRe1_2826 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) TepiRe1_2828 ENOG4105VDK protein, conserved in bacteria TepiRe1_2829 ENOG4105D8X mechanosensitive ion channel TepiRe1_2832 ENOG4108K88 Membrane TepiRe1_2833 ENOG4108ZDA Sporulation protein YyaC TepiRe1_2835 ENOG4108K5P (LipO)protein TepiRe1_2839 ENOG41090HT Inherit from COG: transposase TepiRe1_2841 ENOG4105FA0 parb-like partition protein TepiRe1_2842 ENOG4107QJE Chromosome Partitioning Protein TepiRe1_2845 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) TepiRe1_2846 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) TepiRe1_2847 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) TepiRe1_2848 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein TepiRe1_2849 ENOG4107R4E Membrane TepiRe1_2850 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) TepiRe1_2851 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) TepiRe1_2852 ENOG4105VG0 50S ribosomal protein l34