locus-tag	class	description
TepiRe1_0002	COG0592	DNA-directed DNA polymerase activity
TepiRe1_0003	COG2501	S4 domain
TepiRe1_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TepiRe1_0007	COG0187	DNA topoisomerase II activity
TepiRe1_0008	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TepiRe1_0009	COG1982	Orn Lys Arg decarboxylase major
TepiRe1_0010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TepiRe1_0011	COG3870	Protein conserved in bacteria
TepiRe1_0012	COG1728	Protein conserved in bacteria
TepiRe1_0014	COG1774	PSP1 C-terminal conserved region
TepiRe1_0015	COG2738	Putative neutral zinc metallopeptidase
TepiRe1_0016	COG3829	transcription factor binding
TepiRe1_0016	COG3290	protein histidine kinase activity
TepiRe1_0018	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TepiRe1_0020	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TepiRe1_0021	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TepiRe1_0035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TepiRe1_0036	COG2002	toxin-antitoxin pair type II binding
TepiRe1_0039	COG1396	sequence-specific DNA binding
TepiRe1_0040	COG0006	proline dipeptidase activity
TepiRe1_0041	COG4166	transmembrane transport
TepiRe1_0042	COG0601	transmembrane transport
TepiRe1_0043	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TepiRe1_0044	COG0444	Belongs to the ABC transporter superfamily
TepiRe1_0045	COG4608	Belongs to the ABC transporter superfamily
TepiRe1_0048	COG1012	belongs to the aldehyde dehydrogenase family
TepiRe1_0051	COG2610	gluconate transmembrane transporter activity
TepiRe1_0054	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TepiRe1_0054	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TepiRe1_0060	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TepiRe1_0061	COG1473	amidohydrolase
TepiRe1_0062	COG1473	amidohydrolase
TepiRe1_0070	COG1053	succinate dehydrogenase
TepiRe1_0073	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TepiRe1_0073	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TepiRe1_0076	COG0084	hydrolase, TatD family'
TepiRe1_0078	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TepiRe1_0079	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TepiRe1_0082	COG2385	sporulation resulting in formation of a cellular spore
TepiRe1_0083	COG4466	Protein conserved in bacteria
TepiRe1_0085	COG2340	Cysteine-rich secretory protein family
TepiRe1_0088	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TepiRe1_0089	COG1802	Transcriptional regulator
TepiRe1_0090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TepiRe1_0091	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TepiRe1_0092	COG2088	sporulation resulting in formation of a cellular spore
TepiRe1_0093	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TepiRe1_0094	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TepiRe1_0096	COG0193	aminoacyl-tRNA hydrolase activity
TepiRe1_0100	COG2081	HI0933 family
TepiRe1_0101	COG1396	sequence-specific DNA binding
TepiRe1_0105	COG3443	Belongs to the bacterial solute-binding protein 9 family
TepiRe1_0105	COG0803	Belongs to the bacterial solute-binding protein 9 family
TepiRe1_0106	COG1121	(ABC) transporter
TepiRe1_0107	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TepiRe1_0108	COG0735	belongs to the Fur family
TepiRe1_0115	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TepiRe1_0119	COG4865	methylaspartate mutase activity
TepiRe1_0120	COG3799	methylaspartate ammonia-lyase activity
TepiRe1_0121	COG3799	methylaspartate ammonia-lyase activity
TepiRe1_0125	COG4086	secreted protein
TepiRe1_0127	COG1181	Belongs to the D-alanine--D-alanine ligase family
TepiRe1_0144	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TepiRe1_0145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TepiRe1_0153	COG3829	transcription factor binding
TepiRe1_0154	COG1362	aminopeptidase activity
TepiRe1_0155	COG1362	aminopeptidase activity
TepiRe1_0158	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TepiRe1_0160	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TepiRe1_0162	COG2183	response to ionizing radiation
TepiRe1_0165	COG0789	Transcriptional regulator
TepiRe1_0166	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TepiRe1_0167	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TepiRe1_0168	COG0473	3-isopropylmalate dehydrogenase activity
TepiRe1_0169	COG2302	S4 RNA-binding domain
TepiRe1_0171	COG1785	Belongs to the alkaline phosphatase family
TepiRe1_0172	COG1785	Belongs to the alkaline phosphatase family
TepiRe1_0175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TepiRe1_0176	COG0561	phosphatase activity
TepiRe1_0178	COG0534	Mate efflux family protein
TepiRe1_0181	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TepiRe1_0183	COG2002	toxin-antitoxin pair type II binding
TepiRe1_0184	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TepiRe1_0185	COG2244	polysaccharide biosynthetic process
TepiRe1_0186	COG3956	TIGRFAM MazG family protein
TepiRe1_0189	COG2385	sporulation resulting in formation of a cellular spore
TepiRe1_0193	COG1098	S1 RNA binding domain
TepiRe1_0196	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TepiRe1_0198	COG1358	cellular component organization or biogenesis
TepiRe1_0199	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TepiRe1_0201	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TepiRe1_0202	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TepiRe1_0203	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TepiRe1_0204	COG0088	Forms part of the polypeptide exit tunnel
TepiRe1_0205	COG0089	rRNA binding
TepiRe1_0206	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TepiRe1_0208	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TepiRe1_0209	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TepiRe1_0211	COG0255	Belongs to the universal ribosomal protein uL29 family
TepiRe1_0212	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TepiRe1_0214	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TepiRe1_0215	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TepiRe1_0216	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TepiRe1_0217	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TepiRe1_0218	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TepiRe1_0219	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TepiRe1_0220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TepiRe1_0221	COG0200	Binds to the 23S rRNA
TepiRe1_0222	COG0201	protein transport
TepiRe1_0223	COG0563	adenylate kinase activity
TepiRe1_0224	COG0024	Methionine aminopeptidase
TepiRe1_0226	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TepiRe1_0227	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TepiRe1_0228	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TepiRe1_0229	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TepiRe1_0230	COG0202	RNA polymerase activity
TepiRe1_0231	COG0203	ribosomal protein L17
TepiRe1_0232	COG1122	ATPase activity
TepiRe1_0235	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TepiRe1_0236	COG0101	tRNA pseudouridine synthase activity
TepiRe1_0237	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TepiRe1_0238	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TepiRe1_0239	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TepiRe1_0240	COG1160	GTP binding
TepiRe1_0241	COG0534	Mate efflux family protein
TepiRe1_0245	COG0492	ferredoxin-NADP+ reductase activity
TepiRe1_0247	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TepiRe1_0250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TepiRe1_0256	COG1846	Transcriptional regulator
TepiRe1_0259	COG0309	Hydrogenase expression formation protein (HypE)
TepiRe1_0261	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TepiRe1_0263	COG3069	C4-dicarboxylate transmembrane transporter activity
TepiRe1_0266	COG0489	protein tyrosine kinase activity
TepiRe1_0267	COG2894	cell division
TepiRe1_0267	COG2894	cell division
TepiRe1_0268	COG1342	Belongs to the UPF0251 family
TepiRe1_0276	COG1472	Belongs to the glycosyl hydrolase 3 family
TepiRe1_0284	COG0640	Transcriptional regulator
TepiRe1_0298	COG0191	fructose-bisphosphate aldolase activity
TepiRe1_0299	COG1063	alcohol dehydrogenase
TepiRe1_0300	COG3716	PTS system mannose fructose sorbose family IID component
TepiRe1_0301	COG3715	PTS system
TepiRe1_0302	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TepiRe1_0312	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TepiRe1_0313	COG0789	Transcriptional regulator
TepiRe1_0313	COG4978	Transcriptional regulator
TepiRe1_0314	COG1238	metal cluster binding
TepiRe1_0325	COG5012	cobalamin binding
TepiRe1_0326	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TepiRe1_0328	COG5012	cobalamin binding
TepiRe1_0335	COG5012	cobalamin binding
TepiRe1_0339	COG3404	Formiminotransferase-cyclodeaminase
TepiRe1_0343	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TepiRe1_0345	COG5012	cobalamin binding
TepiRe1_0347	COG2188	Transcriptional regulator
TepiRe1_0349	COG1404	Belongs to the peptidase S8 family
TepiRe1_0351	COG5002	protein histidine kinase activity
TepiRe1_0353	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TepiRe1_0355	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TepiRe1_0356	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TepiRe1_0359	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TepiRe1_0362	COG0569	domain protein
TepiRe1_0363	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TepiRe1_0366	COG2226	methyltransferase
TepiRe1_0366	COG1073	alpha beta
TepiRe1_0368	COG0747	negative chemotaxis
TepiRe1_0369	COG0601	transmembrane transport
TepiRe1_0371	COG4172	Belongs to the ABC transporter superfamily
TepiRe1_0375	COG2217	Heavy metal translocating P-type atpase
TepiRe1_0376	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TepiRe1_0380	COG0673	inositol 2-dehydrogenase activity
TepiRe1_0381	COG0534	Mate efflux family protein
TepiRe1_0383	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TepiRe1_0384	COG0509	glycine decarboxylation via glycine cleavage system
TepiRe1_0385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TepiRe1_0386	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TepiRe1_0387	COG3409	Peptidoglycan-binding domain 1 protein
TepiRe1_0387	COG3773	Cell wall hydrolase
TepiRe1_0390	COG1489	DNA binding
TepiRe1_0395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TepiRe1_0396	COG1773	rubredoxin
TepiRe1_0397	COG1773	rubredoxin
TepiRe1_0397	COG1592	Rubrerythrin
TepiRe1_0398	COG1181	Belongs to the D-alanine--D-alanine ligase family
TepiRe1_0403	COG2050	protein possibly involved in aromatic compounds catabolism
TepiRe1_0404	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TepiRe1_0411	COG3858	chitin binding
TepiRe1_0414	COG0493	'glutamate synthase
TepiRe1_0414	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TepiRe1_0417	COG1924	4 iron, 4 sulfur cluster binding
TepiRe1_0418	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TepiRe1_0419	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TepiRe1_0426	COG0768	penicillin binding
TepiRe1_0428	COG0410	ABC transporter
TepiRe1_0429	COG0411	ABC transporter
TepiRe1_0431	COG0559	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_0437	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TepiRe1_0440	COG0482	sulfurtransferase activity
TepiRe1_0444	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TepiRe1_0445	COG0066	3-isopropylmalate dehydratase activity
TepiRe1_0450	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TepiRe1_0453	COG1053	succinate dehydrogenase
TepiRe1_0464	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TepiRe1_0465	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TepiRe1_0466	COG3608	succinylglutamate desuccinylase aspartoacylase
TepiRe1_0466	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TepiRe1_0467	COG3608	succinylglutamate desuccinylase aspartoacylase
TepiRe1_0467	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TepiRe1_0471	COG1120	ATPase activity
TepiRe1_0473	COG0709	Synthesizes selenophosphate from selenide and ATP
TepiRe1_0474	COG0425	Belongs to the sulfur carrier protein TusA family
TepiRe1_0475	COG1104	cysteine desulfurase activity
TepiRe1_0481	COG0235	Class ii aldolase
TepiRe1_0482	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TepiRe1_0484	COG1063	alcohol dehydrogenase
TepiRe1_0485	COG0626	cystathionine gamma-synthase activity
TepiRe1_0486	COG1070	Carbohydrate kinase
TepiRe1_0487	COG0601	transmembrane transport
TepiRe1_0488	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TepiRe1_0490	COG0444	Belongs to the ABC transporter superfamily
TepiRe1_0491	COG4608	Belongs to the ABC transporter superfamily
TepiRe1_0492	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TepiRe1_0493	COG3681	Belongs to the UPF0597 family
TepiRe1_0494	COG0310	cobalt ion transport
TepiRe1_0495	COG1122	ATPase activity
TepiRe1_0496	COG1797	cobyrinic acid a,c-diamide synthase activity
TepiRe1_0501	COG2242	protein methyltransferase activity
TepiRe1_0503	COG2875	Belongs to the precorrin methyltransferase family
TepiRe1_0506	COG2099	Precorrin-6x reductase
TepiRe1_0507	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TepiRe1_0508	COG0181	hydroxymethylbilane synthase activity
TepiRe1_0510	COG0113	porphobilinogen synthase activity
TepiRe1_0511	COG1648	precorrin-2 dehydrogenase activity
TepiRe1_0511	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TepiRe1_0512	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TepiRe1_0513	COG0363	glucosamine-6-phosphate deaminase activity
TepiRe1_0517	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TepiRe1_0520	COG2207	Transcriptional regulator
TepiRe1_0520	COG4753	response regulator
TepiRe1_0521	COG2972	Histidine kinase
TepiRe1_0522	COG1129	ABC transporter
TepiRe1_0523	COG1129	ABC transporter
TepiRe1_0524	COG1172	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_0528	COG0071	Belongs to the small heat shock protein (HSP20) family
TepiRe1_0529	COG0736	holo-[acyl-carrier-protein] synthase activity
TepiRe1_0530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TepiRe1_0530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TepiRe1_0531	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TepiRe1_0532	COG0864	Transcriptional regulator
TepiRe1_0533	COG2337	Toxic component of a toxin-antitoxin (TA) module
TepiRe1_0535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TepiRe1_0536	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TepiRe1_0537	COG2362	D-Aminopeptidase
TepiRe1_0539	COG0802	atpase or kinase
TepiRe1_0540	COG1214	PFAM Peptidase M22, glycoprotease
TepiRe1_0541	COG0456	acetyltransferase
TepiRe1_0542	COG0110	maltose O-acetyltransferase activity
TepiRe1_0544	COG0488	(ABC) transporter
TepiRe1_0547	COG0281	malic enzyme
TepiRe1_0552	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TepiRe1_0553	COG1285	pathogenesis
TepiRe1_0554	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TepiRe1_0556	COG2252	PERMEase
TepiRe1_0559	COG1269	ATP hydrolysis coupled proton transport
TepiRe1_0560	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TepiRe1_0565	COG1394	ATPase activity, coupled to movement of substances
TepiRe1_0583	COG0758	DNA mediated transformation
TepiRe1_0592	COG2267	carboxylic ester hydrolase activity
TepiRe1_0596	COG0673	inositol 2-dehydrogenase activity
TepiRe1_0597	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TepiRe1_0598	COG1151	hydroxylamine reductase activity
TepiRe1_0602	COG3404	Formiminotransferase-cyclodeaminase
TepiRe1_0603	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TepiRe1_0604	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TepiRe1_0607	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TepiRe1_0608	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TepiRe1_0609	COG1192	Involved in chromosome partitioning
TepiRe1_0614	COG0509	glycine decarboxylation via glycine cleavage system
TepiRe1_0620	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TepiRe1_0621	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TepiRe1_0624	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TepiRe1_0625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TepiRe1_0626	COG0446	pyridine nucleotide-disulphide oxidoreductase
TepiRe1_0630	COG2376	Dihydroxyacetone kinase
TepiRe1_0632	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
TepiRe1_0634	COG0432	Pfam Uncharacterised protein family UPF0047
TepiRe1_0636	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TepiRe1_0637	COG0561	phosphatase activity
TepiRe1_0639	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TepiRe1_0640	COG2084	Dehydrogenase
TepiRe1_0641	COG0662	Cupin 2, conserved barrel domain protein
TepiRe1_0641	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TepiRe1_0642	COG3835	regulator
TepiRe1_0643	COG3842	ATPase activity
TepiRe1_0645	COG0681	Belongs to the peptidase S26 family
TepiRe1_0647	COG0012	GTP binding
TepiRe1_0650	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TepiRe1_0654	COG0860	N-Acetylmuramoyl-L-alanine amidase
TepiRe1_0655	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
TepiRe1_0657	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TepiRe1_0658	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TepiRe1_0660	COG0544	peptidyl-prolyl cis-trans isomerase activity
TepiRe1_0661	COG0740	serine-type endopeptidase activity
TepiRe1_0662	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TepiRe1_0663	COG1067	ATP-dependent peptidase activity
TepiRe1_0663	COG0470	DNA polymerase III
TepiRe1_0664	COG1388	LysM domain
TepiRe1_0664	COG3858	chitin binding
TepiRe1_0666	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TepiRe1_0667	COG4496	protein, YerC YecD
TepiRe1_0671	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TepiRe1_0671	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TepiRe1_0673	COG3414	Phosphotransferase system galactitol-specific IIB component
TepiRe1_0674	COG3775	system Galactitol-specific IIC component
TepiRe1_0675	COG1063	alcohol dehydrogenase
TepiRe1_0676	COG1063	alcohol dehydrogenase
TepiRe1_0682	COG0489	protein tyrosine kinase activity
TepiRe1_0692	COG2390	Transcriptional regulator
TepiRe1_0695	COG3732	PTS system glucitol sorbitol-specific
TepiRe1_0698	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TepiRe1_0699	COG0022	dehydrogenase e1 component
TepiRe1_0700	COG0508	dehydrogenase complex catalyzes the overall conversion of
TepiRe1_0701	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TepiRe1_0702	COG1027	Aspartate ammonia-lyase
TepiRe1_0703	COG0423	glycine-tRNA ligase activity
TepiRe1_0704	COG1609	Transcriptional regulator
TepiRe1_0705	COG1879	ABC-type sugar transport system periplasmic component
TepiRe1_0706	COG1129	ABC transporter
TepiRe1_0707	COG1172	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_0708	COG1063	alcohol dehydrogenase
TepiRe1_0709	COG1063	alcohol dehydrogenase
TepiRe1_0710	COG1402	creatininase
TepiRe1_0711	COG0673	inositol 2-dehydrogenase activity
TepiRe1_0712	COG1082	Xylose isomerase domain protein TIM barrel
TepiRe1_0718	COG0124	histidyl-tRNA synthetase
TepiRe1_0719	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TepiRe1_0722	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TepiRe1_0723	COG0107	imidazoleglycerol-phosphate synthase activity
TepiRe1_0724	COG0140	phosphoribosyl-ATP diphosphatase activity
TepiRe1_0724	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TepiRe1_0728	COG4399	Belongs to the UPF0754 family
TepiRe1_0728	COG4399	Belongs to the UPF0754 family
TepiRe1_0729	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TepiRe1_0730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TepiRe1_0732	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TepiRe1_0733	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TepiRe1_0734	COG0569	domain protein
TepiRe1_0735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TepiRe1_0736	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TepiRe1_0737	COG0072	phenylalanine-tRNA ligase activity
TepiRe1_0737	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TepiRe1_0738	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TepiRe1_0739	COG1796	DNA polymerase
TepiRe1_0739	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TepiRe1_0740	COG1193	negative regulation of DNA recombination
TepiRe1_0743	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TepiRe1_0747	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TepiRe1_0748	COG3481	metal-dependent phosphohydrolase, HD sub domain
TepiRe1_0749	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TepiRe1_0750	COG2222	sugar isomerase
TepiRe1_0751	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TepiRe1_0754	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TepiRe1_0760	COG2239	Acts as a magnesium transporter
TepiRe1_0761	COG2239	Acts as a magnesium transporter
TepiRe1_0762	COG3679	Belongs to the UPF0342 family
TepiRe1_0763	COG1660	Displays ATPase and GTPase activities
TepiRe1_0764	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TepiRe1_0765	COG1481	regulation of sporulation
TepiRe1_0766	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TepiRe1_0767	COG4109	DRTGG domain
TepiRe1_0770	COG0205	6-phosphofructokinase activity
TepiRe1_0772	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TepiRe1_0774	COG1307	EDD domain protein, DegV family
TepiRe1_0778	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TepiRe1_0780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TepiRe1_0780	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TepiRe1_0782	COG1129	ABC transporter
TepiRe1_0783	COG1172	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_0784	COG0673	inositol 2-dehydrogenase activity
TepiRe1_0785	COG1082	Xylose isomerase domain protein TIM barrel
TepiRe1_0786	COG1940	carbohydrate kinase activity
TepiRe1_0787	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TepiRe1_0793	COG1827	regulation of RNA biosynthetic process
TepiRe1_0797	COG0697	spore germination
TepiRe1_0799	COG0095	Lipoate-protein ligase
TepiRe1_0800	COG1321	iron dependent repressor
TepiRe1_0802	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TepiRe1_0803	COG1940	carbohydrate kinase activity
TepiRe1_0804	COG1940	carbohydrate kinase activity
TepiRe1_0805	COG0191	fructose-bisphosphate aldolase activity
TepiRe1_0806	COG2222	sugar isomerase
TepiRe1_0808	COG1879	ABC-type sugar transport system periplasmic component
TepiRe1_0810	COG4211	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_0813	COG3693	PFAM glycoside hydrolase, family 10
TepiRe1_0818	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TepiRe1_0832	COG0745	RESPONSE REGULATOR receiver
TepiRe1_0833	COG2205	protein histidine kinase activity
TepiRe1_0833	COG2770	Histidine kinase
TepiRe1_0834	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TepiRe1_0837	COG2986	histidine ammonia-lyase
TepiRe1_0838	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TepiRe1_0839	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TepiRe1_0841	COG1228	amidohydrolase
TepiRe1_0842	COG3404	Formiminotransferase-cyclodeaminase
TepiRe1_0845	COG4166	transmembrane transport
TepiRe1_0846	COG0601	transmembrane transport
TepiRe1_0847	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TepiRe1_0848	COG0444	Belongs to the ABC transporter superfamily
TepiRe1_0849	COG4608	Belongs to the ABC transporter superfamily
TepiRe1_0856	COG0438	transferase activity, transferring glycosyl groups
TepiRe1_0864	COG1971	Probably functions as a manganese efflux pump
TepiRe1_0865	COG4191	Histidine kinase
TepiRe1_0866	COG0784	Response regulator, receiver
TepiRe1_0871	COG1704	LemA family
TepiRe1_0873	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TepiRe1_0874	COG1278	Cold shock
TepiRe1_0888	COG0653	protein targeting
TepiRe1_0889	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TepiRe1_0890	COG0428	transporter
TepiRe1_0891	COG1040	competence protein
TepiRe1_0895	COG4786	Flagellar basal body rod
TepiRe1_0895	COG1256	bacterial-type flagellum assembly
TepiRe1_0896	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TepiRe1_0898	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TepiRe1_0899	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TepiRe1_0906	COG1598	PFAM Uncharacterised protein family UPF0150
TepiRe1_0918	COG0012	GTP binding
TepiRe1_0926	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TepiRe1_0927	COG1516	flagellar protein fliS
TepiRe1_0934	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TepiRe1_0936	COG0840	transmembrane signaling receptor activity
TepiRe1_0939	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TepiRe1_0945	COG1162	GTPase activity
TepiRe1_0964	COG3708	Transcriptional regulator
TepiRe1_0964	COG2207	Transcriptional regulator
TepiRe1_0977	COG0745	RESPONSE REGULATOR receiver
TepiRe1_0979	COG1131	(ABC) transporter
TepiRe1_0983	COG0488	(ABC) transporter
TepiRe1_0991	COG3290	protein histidine kinase activity
TepiRe1_0994	COG3279	Response regulator of the LytR AlgR family
TepiRe1_1003	COG3328	transposase activity
TepiRe1_1016	COG0840	transmembrane signaling receptor activity
TepiRe1_1039	COG1396	sequence-specific DNA binding
TepiRe1_1040	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TepiRe1_1045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TepiRe1_1055	COG0745	RESPONSE REGULATOR receiver
TepiRe1_1056	COG2205	protein histidine kinase activity
TepiRe1_1063	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TepiRe1_1064	COG0534	Mate efflux family protein
TepiRe1_1065	COG3584	3D domain protein
TepiRe1_1065	COG3583	domain protein
TepiRe1_1066	COG1686	Belongs to the peptidase S11 family
TepiRe1_1069	COG2323	membrane
TepiRe1_1071	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TepiRe1_1074	COG1205	dead DEAH box helicase
TepiRe1_1074	COG1111	helicase
TepiRe1_1075	COG3359	exonuclease
TepiRe1_1077	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TepiRe1_1078	COG0573	inorganic phosphate transmembrane transporter activity
TepiRe1_1079	COG0581	inorganic phosphate transmembrane transporter activity
TepiRe1_1080	COG0745	RESPONSE REGULATOR receiver
TepiRe1_1081	COG5002	protein histidine kinase activity
TepiRe1_1082	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TepiRe1_1083	COG0704	Plays a role in the regulation of phosphate uptake
TepiRe1_1084	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TepiRe1_1088	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TepiRe1_1092	COG1131	(ABC) transporter
TepiRe1_1096	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TepiRe1_1097	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TepiRe1_1100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TepiRe1_1102	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TepiRe1_1103	COG0406	alpha-ribazole phosphatase activity
TepiRe1_1104	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TepiRe1_1109	COG1595	DNA-templated transcription, initiation
TepiRe1_1113	COG2602	Beta-lactamase
TepiRe1_1113	COG4219	Peptidase M56
TepiRe1_1116	COG0860	N-Acetylmuramoyl-L-alanine amidase
TepiRe1_1116	COG1388	LysM domain
TepiRe1_1117	COG0557	exoribonuclease II activity
TepiRe1_1120	COG1396	sequence-specific DNA binding
TepiRe1_1130	COG0305	Participates in initiation and elongation during chromosome replication
TepiRe1_1133	COG2052	Domain of unknown function (DUF370)
TepiRe1_1134	COG0629	single-stranded DNA binding
TepiRe1_1143	COG5484	DNA packaging
TepiRe1_1144	COG1783	phage Terminase large subunit
TepiRe1_1167	COG0116	Belongs to the methyltransferase superfamily
TepiRe1_1168	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TepiRe1_1171	COG0671	phosphoesterase, PA-phosphatase related
TepiRe1_1172	COG0436	Aminotransferase
TepiRe1_1173	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TepiRe1_1174	COG0047	phosphoribosylformylglycinamidine synthase activity
TepiRe1_1175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TepiRe1_1176	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TepiRe1_1177	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TepiRe1_1178	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TepiRe1_1179	COG0138	bifunctional purine biosynthesis protein purh
TepiRe1_1180	COG0151	Belongs to the GarS family
TepiRe1_1181	COG1592	Rubrerythrin
TepiRe1_1182	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TepiRe1_1184	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TepiRe1_1185	COG0658	competence protein
TepiRe1_1185	COG2333	competence protein COMEC
TepiRe1_1186	COG1466	dna polymerase III delta subunit
TepiRe1_1187	COG0268	Binds directly to 16S ribosomal RNA
TepiRe1_1189	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TepiRe1_1192	COG0481	GTPase activity
TepiRe1_1193	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TepiRe1_1194	COG1420	regulation of RNA biosynthetic process
TepiRe1_1195	COG0459	protein refolding
TepiRe1_1197	COG0443	Heat shock 70 kDa protein
TepiRe1_1198	COG0484	heat shock protein binding
TepiRe1_1199	COG2264	protein methyltransferase activity
TepiRe1_1200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TepiRe1_1201	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TepiRe1_1202	COG0537	adenosine 5'-monophosphoramidase activity
TepiRe1_1203	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TepiRe1_1204	COG1610	YqeY-like protein
TepiRe1_1205	COG1030	water channel activity
TepiRe1_1206	COG4864	UPF0365 protein
TepiRe1_1210	COG1702	phosphate starvation-inducible protein PhoH
TepiRe1_1211	COG1480	7TM receptor with intracellular HD hydrolase
TepiRe1_1212	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TepiRe1_1213	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TepiRe1_1214	COG1470	cell adhesion involved in biofilm formation
TepiRe1_1215	COG1381	Involved in DNA repair and RecF pathway recombination
TepiRe1_1216	COG0517	IMP dehydrogenase activity
TepiRe1_1217	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TepiRe1_1218	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TepiRe1_1218	COG0574	Belongs to the PEP-utilizing enzyme family
TepiRe1_1219	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TepiRe1_1220	COG0358	DNA primase activity
TepiRe1_1221	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TepiRe1_1223	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TepiRe1_1225	COG0328	RNA-DNA hybrid ribonuclease activity
TepiRe1_1227	COG2703	oxygen carrier activity
TepiRe1_1230	COG0612	Peptidase, M16
TepiRe1_1231	COG0612	Peptidase, M16
TepiRe1_1232	COG2001	Belongs to the MraZ family
TepiRe1_1234	COG3116	cell division
TepiRe1_1235	COG0768	penicillin binding
TepiRe1_1237	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TepiRe1_1238	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TepiRe1_1239	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TepiRe1_1240	COG0772	Belongs to the SEDS family
TepiRe1_1241	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TepiRe1_1242	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TepiRe1_1243	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TepiRe1_1246	COG3856	small basic protein
TepiRe1_1248	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TepiRe1_1251	COG1191	sigma factor activity
TepiRe1_1252	COG1191	sigma factor activity
TepiRe1_1254	COG1873	PFAM PRC-barrel domain
TepiRe1_1255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TepiRe1_1256	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TepiRe1_1262	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TepiRe1_1264	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TepiRe1_1265	COG1254	Belongs to the acylphosphatase family
TepiRe1_1266	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TepiRe1_1267	COG2201	protein-glutamate methylesterase activity
TepiRe1_1268	COG3191	aminopeptidase activity
TepiRe1_1277	COG3409	Peptidoglycan-binding domain 1 protein
TepiRe1_1277	COG3773	Cell wall hydrolase
TepiRe1_1278	COG1739	Uncharacterized protein family UPF0029
TepiRe1_1279	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TepiRe1_1280	COG0217	transcriptional regulatory protein
TepiRe1_1283	COG0632	four-way junction helicase activity
TepiRe1_1284	COG2255	four-way junction helicase activity
TepiRe1_1285	COG2385	sporulation resulting in formation of a cellular spore
TepiRe1_1286	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TepiRe1_1289	COG1862	Preprotein translocase
TepiRe1_1291	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TepiRe1_1292	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TepiRe1_1295	COG2030	dehydratase
TepiRe1_1297	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TepiRe1_1299	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TepiRe1_1300	COG1028	Short-chain dehydrogenase reductase Sdr
TepiRe1_1301	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TepiRe1_1302	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TepiRe1_1303	COG0571	ribonuclease III activity
TepiRe1_1304	COG2359	stage V sporulation protein S
TepiRe1_1305	COG1196	nuclear chromosome segregation
TepiRe1_1306	COG0552	protein localization to endoplasmic reticulum
TepiRe1_1307	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
TepiRe1_1308	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TepiRe1_1309	COG0228	four-way junction DNA binding
TepiRe1_1312	COG0336	Belongs to the RNA methyltransferase TrmD family
TepiRe1_1313	COG0335	large ribosomal subunit rRNA binding
TepiRe1_1315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TepiRe1_1316	COG0792	nuclease activity
TepiRe1_1317	COG0606	chelatase, subunit chli
TepiRe1_1318	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TepiRe1_1319	COG0758	DNA mediated transformation
TepiRe1_1320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TepiRe1_1321	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TepiRe1_1322	COG4974	Belongs to the 'phage' integrase family
TepiRe1_1323	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TepiRe1_1324	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TepiRe1_1326	COG1815	bacterial-type flagellum-dependent cell motility
TepiRe1_1328	COG1677	Flagellar hook-basal body complex protein FliE
TepiRe1_1329	COG1766	The M ring may be actively involved in energy transduction
TepiRe1_1330	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TepiRe1_1332	COG1157	protein secretion by the type III secretion system
TepiRe1_1336	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TepiRe1_1343	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TepiRe1_1344	COG1776	CheC inhibitor of MCP methylation
TepiRe1_1344	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TepiRe1_1345	COG2201	protein-glutamate methylesterase activity
TepiRe1_1347	COG1338	Plays a role in the flagellum-specific transport system
TepiRe1_1348	COG1987	bacterial-type flagellum assembly
TepiRe1_1349	COG1684	flagellar biosynthetic protein fliR
TepiRe1_1350	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TepiRe1_1351	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TepiRe1_1352	COG1419	protein localization to endoplasmic reticulum
TepiRe1_1353	COG0455	bacterial-type flagellum organization
TepiRe1_1355	COG2198	Histidine kinase
TepiRe1_1355	COG0643	Histidine kinase
TepiRe1_1356	COG0835	chemotaxis
TepiRe1_1357	COG1776	CheC inhibitor of MCP methylation
TepiRe1_1358	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TepiRe1_1359	COG1191	sigma factor activity
TepiRe1_1364	COG0628	permease
TepiRe1_1365	COG0052	Belongs to the universal ribosomal protein uS2 family
TepiRe1_1366	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TepiRe1_1367	COG0528	UMP kinase activity
TepiRe1_1368	COG0233	cytoplasmic translational termination
TepiRe1_1370	COG4589	Belongs to the CDS family
TepiRe1_1371	COG0628	permease
TepiRe1_1372	COG0750	zinc metalloprotease
TepiRe1_1373	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TepiRe1_1374	COG0442	prolyl-tRNA aminoacylation
TepiRe1_1376	COG2176	DNA-directed DNA polymerase activity
TepiRe1_1378	COG0195	Participates in both transcription termination and antitermination
TepiRe1_1379	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TepiRe1_1380	COG1358	cellular component organization or biogenesis
TepiRe1_1381	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TepiRe1_1383	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TepiRe1_1384	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TepiRe1_1385	COG0196	riboflavin kinase activity
TepiRe1_1386	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TepiRe1_1387	COG1185	polyribonucleotide nucleotidyltransferase activity
TepiRe1_1388	COG0726	polysaccharide deacetylase
TepiRe1_1389	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TepiRe1_1390	COG0756	dUTP diphosphatase activity
TepiRe1_1392	COG1873	PFAM PRC-barrel domain
TepiRe1_1393	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TepiRe1_1394	COG0740	serine-type endopeptidase activity
TepiRe1_1396	COG1674	ftsk spoiiie
TepiRe1_1397	COG1426	Protein conserved in bacteria
TepiRe1_1398	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TepiRe1_1400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TepiRe1_1402	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TepiRe1_1403	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TepiRe1_1405	COG1196	nuclear chromosome segregation
TepiRe1_1409	COG1692	metallophosphoesterase
TepiRe1_1410	COG2359	stage V sporulation protein S
TepiRe1_1411	COG0613	PHP domain protein
TepiRe1_1413	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TepiRe1_1413	COG0674	pyruvate-flavodoxin oxidoreductase activity
TepiRe1_1414	COG1013	pyruvate-flavodoxin oxidoreductase activity
TepiRe1_1418	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TepiRe1_1418	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TepiRe1_1419	COG1703	isobutyryl-CoA mutase activity
TepiRe1_1420	COG0346	lactoylglutathione lyase activity
TepiRe1_1421	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TepiRe1_1423	COG4770	biotin carboxylase activity
TepiRe1_1424	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TepiRe1_1427	COG2720	vancomycin resistance protein
TepiRe1_1430	COG1573	uracil-dna glycosylase
TepiRe1_1431	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TepiRe1_1433	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TepiRe1_1434	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TepiRe1_1435	COG1923	regulation of RNA biosynthetic process
TepiRe1_1436	COG0464	growth
TepiRe1_1437	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TepiRe1_1440	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TepiRe1_1441	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TepiRe1_1445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TepiRe1_1451	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TepiRe1_1453	COG1304	FMN binding
TepiRe1_1454	COG0539	negative regulation of cytoplasmic translation
TepiRe1_1454	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TepiRe1_1457	COG2081	HI0933 family
TepiRe1_1459	COG1120	ATPase activity
TepiRe1_1460	COG0010	Belongs to the arginase family
TepiRe1_1461	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TepiRe1_1463	COG1187	pseudouridine synthase activity
TepiRe1_1466	COG5012	cobalamin binding
TepiRe1_1469	COG0445	tRNA wobble uridine modification
TepiRe1_1470	COG1921	L-seryl-tRNASec selenium transferase activity
TepiRe1_1473	COG3874	Sporulation protein YtfJ
TepiRe1_1475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TepiRe1_1477	COG0180	Tryptophanyl-tRNA synthetase
TepiRe1_1478	COG1994	Peptidase M50
TepiRe1_1479	COG0019	diaminopimelate decarboxylase activity
TepiRe1_1480	COG1924	4 iron, 4 sulfur cluster binding
TepiRe1_1485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TepiRe1_1487	COG3360	Dodecin
TepiRe1_1488	COG1191	sigma factor activity
TepiRe1_1489	COG2172	sigma factor antagonist activity
TepiRe1_1490	COG1366	Belongs to the anti-sigma-factor antagonist family
TepiRe1_1491	COG1686	Belongs to the peptidase S11 family
TepiRe1_1492	COG4974	Belongs to the 'phage' integrase family
TepiRe1_1493	COG1300	Membrane
TepiRe1_1494	COG1379	DNA repair
TepiRe1_1497	COG0750	zinc metalloprotease
TepiRe1_1498	COG0497	DNA recombination
TepiRe1_1499	COG1438	arginine binding
TepiRe1_1500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TepiRe1_1502	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TepiRe1_1505	COG1722	exodeoxyribonuclease VII activity
TepiRe1_1506	COG1570	exodeoxyribonuclease VII activity
TepiRe1_1507	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TepiRe1_1510	COG1302	Protein conserved in bacteria
TepiRe1_1518	COG3854	ATPases associated with a variety of cellular activities
TepiRe1_1520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TepiRe1_1521	COG0006	proline dipeptidase activity
TepiRe1_1531	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TepiRe1_1532	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TepiRe1_1533	COG1191	sigma factor activity
TepiRe1_1534	COG0768	penicillin binding
TepiRe1_1535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TepiRe1_1538	COG0735	belongs to the Fur family
TepiRe1_1539	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TepiRe1_1540	COG3906	Belongs to the UPF0473 family
TepiRe1_1541	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TepiRe1_1542	COG0667	Aldo Keto reductase
TepiRe1_1543	COG4472	Bacterial protein of unknown function (DUF965)
TepiRe1_1544	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TepiRe1_1546	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TepiRe1_1547	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TepiRe1_1548	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TepiRe1_1550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TepiRe1_1551	COG1490	D-aminoacyl-tRNA deacylase activity
TepiRe1_1552	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TepiRe1_1553	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TepiRe1_1554	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TepiRe1_1554	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TepiRe1_1559	COG0280	phosphate acetyltransferase
TepiRe1_1561	COG3480	Lon protease (S16) C-terminal proteolytic domain
TepiRe1_1563	COG3314	Sporulation integral membrane protein YlbJ
TepiRe1_1565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TepiRe1_1566	COG0742	ribosomal rna small subunit methyltransferase
TepiRe1_1568	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TepiRe1_1569	COG1461	Dihydroxyacetone kinase
TepiRe1_1570	COG1302	Protein conserved in bacteria
TepiRe1_1573	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TepiRe1_1574	COG0515	serine threonine protein kinase
TepiRe1_1574	COG2815	serine threonine protein kinase
TepiRe1_1575	COG0631	protein serine/threonine phosphatase activity
TepiRe1_1576	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TepiRe1_1577	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TepiRe1_1577	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TepiRe1_1579	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TepiRe1_1581	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TepiRe1_1582	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TepiRe1_1584	COG0194	GDP metabolic process
TepiRe1_1586	COG1561	YicC-like family, N-terminal region
TepiRe1_1589	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TepiRe1_1590	COG0564	pseudouridine synthase activity
TepiRe1_1591	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TepiRe1_1592	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TepiRe1_1594	COG3599	regulation of cell shape
TepiRe1_1596	COG1799	cell septum assembly
TepiRe1_1597	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TepiRe1_1600	COG0083	homoserine kinase activity
TepiRe1_1601	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TepiRe1_1602	COG0460	homoserine dehydrogenase
TepiRe1_1603	COG4492	Belongs to the UPF0735 family
TepiRe1_1605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TepiRe1_1606	COG3409	Peptidoglycan-binding domain 1 protein
TepiRe1_1606	COG0793	Belongs to the peptidase S41A family
TepiRe1_1607	COG2070	2-Nitropropane dioxygenase
TepiRe1_1609	COG1136	(ABC) transporter
TepiRe1_1611	COG0577	efflux transmembrane transporter activity
TepiRe1_1611	COG1136	(ABC) transporter
TepiRe1_1614	COG0525	valine-tRNA ligase activity
TepiRe1_1615	COG1968	undecaprenyl-diphosphatase activity
TepiRe1_1617	COG1555	photosystem II stabilization
TepiRe1_1619	COG0719	Fe-S assembly protein
TepiRe1_1620	COG1137	ATPase activity
TepiRe1_1622	COG0495	leucyl-tRNA aminoacylation
TepiRe1_1624	COG1316	TRANSCRIPTIONal
TepiRe1_1625	COG1713	HD superfamily hydrolase involved in NAD metabolism
TepiRe1_1626	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TepiRe1_1627	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TepiRe1_1630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TepiRe1_1631	COG2868	ribosomal protein
TepiRe1_1634	COG2959	enzyme of heme biosynthesis
TepiRe1_1635	COG3409	Peptidoglycan-binding domain 1 protein
TepiRe1_1635	COG3773	Cell wall hydrolase
TepiRe1_1640	COG1530	ribonuclease E activity
TepiRe1_1645	COG0772	Belongs to the SEDS family
TepiRe1_1647	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TepiRe1_1648	COG2894	cell division
TepiRe1_1649	COG0850	regulation of cytokinetic process
TepiRe1_1650	COG0768	penicillin binding
TepiRe1_1652	COG1792	Involved in formation and maintenance of cell shape
TepiRe1_1653	COG1077	Cell shape determining protein MreB Mrl
TepiRe1_1654	COG2003	Belongs to the UPF0758 family
TepiRe1_1655	COG0424	maF-like protein
TepiRe1_1659	COG1595	DNA-templated transcription, initiation
TepiRe1_1668	COG1063	alcohol dehydrogenase
TepiRe1_1676	COG1063	alcohol dehydrogenase
TepiRe1_1679	COG3829	transcription factor binding
TepiRe1_1679	COG3290	protein histidine kinase activity
TepiRe1_1682	COG0840	transmembrane signaling receptor activity
TepiRe1_1683	COG0700	Nucleoside recognition
TepiRe1_1684	COG2715	membrane protein required for spore maturation
TepiRe1_1685	COG0322	excinuclease ABC activity
TepiRe1_1687	COG0686	Belongs to the AlaDH PNT family
TepiRe1_1689	COG5002	protein histidine kinase activity
TepiRe1_1690	COG0745	RESPONSE REGULATOR receiver
TepiRe1_1694	COG1283	sodium-dependent phosphate transmembrane transporter activity
TepiRe1_1695	COG1283	sodium-dependent phosphate transmembrane transporter activity
TepiRe1_1699	COG1879	ABC-type sugar transport system periplasmic component
TepiRe1_1700	COG4120	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_1702	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TepiRe1_1704	COG2721	sulfolactate sulfo-lyase activity
TepiRe1_1705	COG0246	Mannitol dehydrogenase
TepiRe1_1706	COG3718	enzyme involved in inositol metabolism
TepiRe1_1710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TepiRe1_1716	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TepiRe1_1719	COG0301	tRNA thio-modification
TepiRe1_1722	COG5577	PFAM Coat F domain
TepiRe1_1731	COG0747	negative chemotaxis
TepiRe1_1733	COG2707	UPF0756 membrane protein
TepiRe1_1734	COG0741	lytic transglycosylase activity
TepiRe1_1735	COG0237	dephospho-CoA kinase activity
TepiRe1_1737	COG5662	AntiSigma factor
TepiRe1_1738	COG1595	DNA-templated transcription, initiation
TepiRe1_1742	COG0559	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_1744	COG0428	transporter
TepiRe1_1745	COG0159	tryptophan synthase activity
TepiRe1_1746	COG0133	tryptophan synthase activity
TepiRe1_1751	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TepiRe1_1751	COG0512	Glutamine amidotransferase of anthranilate synthase
TepiRe1_1752	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TepiRe1_1754	COG2723	6-phospho-beta-galactosidase activity
TepiRe1_1755	COG2059	Chromate
TepiRe1_1756	COG2059	Chromate
TepiRe1_1757	COG1940	carbohydrate kinase activity
TepiRe1_1758	COG0641	radical SAM
TepiRe1_1760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TepiRe1_1762	COG1447	Phosphotransferase system cellobiose-specific component IIA
TepiRe1_1767	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TepiRe1_1769	COG1447	Phosphotransferase system cellobiose-specific component IIA
TepiRe1_1770	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TepiRe1_1770	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TepiRe1_1771	COG0840	transmembrane signaling receptor activity
TepiRe1_1773	COG3409	Peptidoglycan-binding domain 1 protein
TepiRe1_1773	COG3773	Cell wall hydrolase
TepiRe1_1774	COG0546	phosphoglycolate phosphatase activity
TepiRe1_1775	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TepiRe1_1778	COG0556	nucleotide-excision repair
TepiRe1_1780	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TepiRe1_1781	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TepiRe1_1782	COG0793	Belongs to the peptidase S41A family
TepiRe1_1783	COG0739	heme binding
TepiRe1_1783	COG0741	lytic transglycosylase activity
TepiRe1_1783	COG1196	nuclear chromosome segregation
TepiRe1_1784	COG2177	Part of the ABC transporter FtsEX involved in
TepiRe1_1785	COG2884	Cell division ATP-binding protein ftsE
TepiRe1_1787	COG0733	neurotransmitter:sodium symporter activity
TepiRe1_1788	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TepiRe1_1797	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TepiRe1_1798	COG3959	Transketolase, thiamine diphosphate binding domain
TepiRe1_1799	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TepiRe1_1802	COG0438	transferase activity, transferring glycosyl groups
TepiRe1_1807	COG0297	glycogen (starch) synthase activity
TepiRe1_1810	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TepiRe1_1812	COG0363	glucosamine-6-phosphate deaminase activity
TepiRe1_1813	COG0191	fructose-bisphosphate aldolase activity
TepiRe1_1816	COG1376	ErfK ybiS ycfS ynhG family protein
TepiRe1_1817	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TepiRe1_1818	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TepiRe1_1819	COG1691	(AIR) carboxylase
TepiRe1_1820	COG1606	tRNA processing
TepiRe1_1821	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TepiRe1_1822	COG3858	chitin binding
TepiRe1_1825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TepiRe1_1826	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TepiRe1_1828	COG3716	PTS system mannose fructose sorbose family IID component
TepiRe1_1829	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TepiRe1_1831	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TepiRe1_1832	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TepiRe1_1832	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TepiRe1_1833	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TepiRe1_1833	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TepiRe1_1836	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TepiRe1_1839	COG1980	fructose-bisphosphate aldolase activity
TepiRe1_1847	COG2184	nucleotidyltransferase activity
TepiRe1_1855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TepiRe1_1855	COG0519	Catalyzes the synthesis of GMP from XMP
TepiRe1_1856	COG0577	efflux transmembrane transporter activity
TepiRe1_1857	COG1136	(ABC) transporter
TepiRe1_1858	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TepiRe1_1861	COG1131	(ABC) transporter
TepiRe1_1862	COG1725	Transcriptional regulator
TepiRe1_1863	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TepiRe1_1864	COG0456	acetyltransferase
TepiRe1_1867	COG3715	PTS system
TepiRe1_1870	COG1737	Transcriptional regulator
TepiRe1_1871	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TepiRe1_1872	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TepiRe1_1873	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TepiRe1_1874	COG3829	transcription factor binding
TepiRe1_1874	COG3290	protein histidine kinase activity
TepiRe1_1875	COG2190	(PTS) system
TepiRe1_1875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TepiRe1_1875	COG1263	PTS System
TepiRe1_1876	COG3711	transcriptional antiterminator
TepiRe1_1877	COG1263	PTS System
TepiRe1_1877	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TepiRe1_1877	COG2190	(PTS) system
TepiRe1_1878	COG1802	Transcriptional regulator
TepiRe1_1879	COG3718	enzyme involved in inositol metabolism
TepiRe1_1881	COG1063	alcohol dehydrogenase
TepiRe1_1882	COG0673	inositol 2-dehydrogenase activity
TepiRe1_1883	COG0410	ABC transporter
TepiRe1_1886	COG0559	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_1888	COG1028	Short-chain dehydrogenase reductase Sdr
TepiRe1_1889	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TepiRe1_1891	COG1070	Carbohydrate kinase
TepiRe1_1892	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TepiRe1_1893	COG0246	Mannitol dehydrogenase
TepiRe1_1894	COG5001	Diguanylate cyclase
TepiRe1_1894	COG3447	MASE1 domain protein
TepiRe1_1894	COG5002	protein histidine kinase activity
TepiRe1_1897	COG0728	peptidoglycan biosynthetic process
TepiRe1_1903	COG0438	transferase activity, transferring glycosyl groups
TepiRe1_1909	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TepiRe1_1910	COG0736	holo-[acyl-carrier-protein] synthase activity
TepiRe1_1913	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TepiRe1_1915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TepiRe1_1916	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TepiRe1_1926	COG0542	response to heat
TepiRe1_1927	COG1803	Methylglyoxal synthase
TepiRe1_1929	COG0577	efflux transmembrane transporter activity
TepiRe1_1929	COG1136	(ABC) transporter
TepiRe1_1930	COG1136	(ABC) transporter
TepiRe1_1932	COG0585	pseudouridine synthase activity
TepiRe1_1935	COG0726	polysaccharide deacetylase
TepiRe1_1936	COG1187	pseudouridine synthase activity
TepiRe1_1939	COG1028	Short-chain dehydrogenase reductase Sdr
TepiRe1_1941	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TepiRe1_1943	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TepiRe1_1944	COG0281	malic enzyme
TepiRe1_1947	COG0179	Fumarylacetoacetate (FAA) hydrolase
TepiRe1_1948	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TepiRe1_1949	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TepiRe1_1950	COG0410	ABC transporter
TepiRe1_1951	COG0411	ABC transporter
TepiRe1_1953	COG0559	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_1957	COG0745	RESPONSE REGULATOR receiver
TepiRe1_1960	COG1136	(ABC) transporter
TepiRe1_1960	COG0577	efflux transmembrane transporter activity
TepiRe1_1962	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TepiRe1_1963	COG1063	alcohol dehydrogenase
TepiRe1_1965	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TepiRe1_1966	COG1024	Enoyl-CoA hydratase
TepiRe1_1968	COG2030	dehydratase
TepiRe1_1969	COG1082	Xylose isomerase domain protein TIM barrel
TepiRe1_1971	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TepiRe1_1972	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TepiRe1_1973	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TepiRe1_1977	COG0800	Aldolase
TepiRe1_1979	COG4211	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_1981	COG1879	ABC-type sugar transport system periplasmic component
TepiRe1_1982	COG4213	ABC transporter substrate-binding protein
TepiRe1_1983	COG3279	Response regulator of the LytR AlgR family
TepiRe1_1984	COG3275	phosphorelay sensor kinase activity
TepiRe1_1989	COG0840	transmembrane signaling receptor activity
TepiRe1_1991	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TepiRe1_1992	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TepiRe1_1992	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TepiRe1_1994	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TepiRe1_1994	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TepiRe1_1998	COG3732	PTS system glucitol sorbitol-specific
TepiRe1_2001	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TepiRe1_2003	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TepiRe1_2007	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TepiRe1_2009	COG1447	Phosphotransferase system cellobiose-specific component IIA
TepiRe1_2011	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TepiRe1_2011	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TepiRe1_2021	COG3033	Beta-eliminating lyase
TepiRe1_2025	COG3546	catalase activity
TepiRe1_2026	COG1245	4Fe-4S binding domain
TepiRe1_2026	COG2878	Part of a membrane complex involved in electron transport
TepiRe1_2027	COG4657	Part of a membrane complex involved in electron transport
TepiRe1_2028	COG4660	Part of a membrane complex involved in electron transport
TepiRe1_2029	COG4659	FMN binding
TepiRe1_2030	COG4658	electron transport chain
TepiRe1_2031	COG4656	Part of a membrane complex involved in electron transport
TepiRe1_2032	COG2116	formate transmembrane transporter activity
TepiRe1_2036	COG4191	Histidine kinase
TepiRe1_2041	COG2172	sigma factor antagonist activity
TepiRe1_2042	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TepiRe1_2045	COG4608	Belongs to the ABC transporter superfamily
TepiRe1_2046	COG0444	Belongs to the ABC transporter superfamily
TepiRe1_2049	COG0747	negative chemotaxis
TepiRe1_2051	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TepiRe1_2052	COG0154	amidase activity
TepiRe1_2053	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TepiRe1_2058	COG1725	Transcriptional regulator
TepiRe1_2062	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TepiRe1_2062	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TepiRe1_2068	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TepiRe1_2069	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TepiRe1_2072	COG1301	dicarboxylic acid transport
TepiRe1_2073	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TepiRe1_2074	COG0402	S-adenosylhomocysteine deaminase activity
TepiRe1_2079	COG1215	transferase activity, transferring glycosyl groups
TepiRe1_2082	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TepiRe1_2083	COG0028	Belongs to the TPP enzyme family
TepiRe1_2084	COG0473	3-isopropylmalate dehydrogenase activity
TepiRe1_2085	COG0066	3-isopropylmalate dehydratase activity
TepiRe1_2086	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TepiRe1_2087	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TepiRe1_2088	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TepiRe1_2089	COG0440	acetolactate synthase activity
TepiRe1_2090	COG0028	Belongs to the TPP enzyme family
TepiRe1_2097	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TepiRe1_2098	COG1473	amidohydrolase
TepiRe1_2099	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TepiRe1_2101	COG0129	dihydroxy-acid dehydratase activity
TepiRe1_2102	COG1250	3-hydroxyacyl-CoA dehydrogenase
TepiRe1_2103	COG2186	Transcriptional regulator
TepiRe1_2104	COG3958	Transketolase
TepiRe1_2105	COG3959	Transketolase, thiamine diphosphate binding domain
TepiRe1_2109	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TepiRe1_2114	COG2972	Histidine kinase
TepiRe1_2116	COG1126	abc transporter atp-binding protein
TepiRe1_2117	COG0765	amino acid transport
TepiRe1_2119	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TepiRe1_2120	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TepiRe1_2121	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TepiRe1_2123	COG1074	ATP-dependent DNA helicase activity
TepiRe1_2124	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
TepiRe1_2125	COG0148	phosphopyruvate hydratase activity
TepiRe1_2127	COG0149	triose-phosphate isomerase activity
TepiRe1_2128	COG0126	phosphoglycerate kinase activity
TepiRe1_2129	COG2390	Transcriptional regulator
TepiRe1_2131	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TepiRe1_2137	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TepiRe1_2138	COG0527	aspartate kinase activity
TepiRe1_2139	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TepiRe1_2140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TepiRe1_2143	COG0674	pyruvate-flavodoxin oxidoreductase activity
TepiRe1_2143	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TepiRe1_2143	COG1013	pyruvate-flavodoxin oxidoreductase activity
TepiRe1_2143	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TepiRe1_2144	COG1307	EDD domain protein, DegV family
TepiRe1_2148	COG0295	cytidine deaminase activity
TepiRe1_2149	COG2188	Transcriptional regulator
TepiRe1_2158	COG0673	inositol 2-dehydrogenase activity
TepiRe1_2161	COG3290	protein histidine kinase activity
TepiRe1_2163	COG3279	Response regulator of the LytR AlgR family
TepiRe1_2168	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TepiRe1_2169	COG4279	zinc finger
TepiRe1_2171	COG4821	SIS domain
TepiRe1_2174	COG3037	sugar-specific permease SgaT UlaA
TepiRe1_2176	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TepiRe1_2177	COG3875	lactate racemase activity
TepiRe1_2180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TepiRe1_2181	COG0693	protein deglycase activity
TepiRe1_2183	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TepiRe1_2184	COG3457	Alanine racemase
TepiRe1_2185	COG0626	cystathionine gamma-synthase activity
TepiRe1_2186	COG1735	metal-dependent hydrolase with the TIM-barrel fold
TepiRe1_2189	COG3711	transcriptional antiterminator
TepiRe1_2190	COG2188	Transcriptional regulator
TepiRe1_2191	COG0561	phosphatase activity
TepiRe1_2197	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TepiRe1_2199	COG3850	Histidine kinase
TepiRe1_2199	COG5002	protein histidine kinase activity
TepiRe1_2200	COG0745	RESPONSE REGULATOR receiver
TepiRe1_2205	COG4810	utilization protein
TepiRe1_2207	COG0346	lactoylglutathione lyase activity
TepiRe1_2208	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TepiRe1_2209	COG1070	Carbohydrate kinase
TepiRe1_2210	COG0667	Aldo Keto reductase
TepiRe1_2211	COG1172	Belongs to the binding-protein-dependent transport system permease family
TepiRe1_2212	COG1129	ABC transporter
TepiRe1_2213	COG1879	ABC-type sugar transport system periplasmic component
TepiRe1_2216	COG0306	phosphate transporter
TepiRe1_2217	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TepiRe1_2222	COG5416	Lipopolysaccharide assembly protein A domain
TepiRe1_2223	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TepiRe1_2226	COG4786	Flagellar basal body rod
TepiRe1_2227	COG1077	Cell shape determining protein MreB Mrl
TepiRe1_2228	COG1609	Transcriptional regulator
TepiRe1_2230	COG2385	sporulation resulting in formation of a cellular spore
TepiRe1_2231	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TepiRe1_2235	COG1394	ATPase activity, coupled to movement of substances
TepiRe1_2238	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TepiRe1_2239	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TepiRe1_2241	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TepiRe1_2242	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TepiRe1_2243	COG1269	ATP hydrolysis coupled proton transport
TepiRe1_2249	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TepiRe1_2250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TepiRe1_2252	COG3959	Transketolase, thiamine diphosphate binding domain
TepiRe1_2256	COG1653	transport
TepiRe1_2257	COG2186	Transcriptional regulator
TepiRe1_2263	COG2131	deaminase
TepiRe1_2267	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
TepiRe1_2269	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TepiRe1_2271	COG0673	inositol 2-dehydrogenase activity
TepiRe1_2272	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TepiRe1_2273	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TepiRe1_2274	COG0698	ribose 5-phosphate isomerase
TepiRe1_2276	COG0009	L-threonylcarbamoyladenylate synthase
TepiRe1_2278	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TepiRe1_2279	COG3872	metal-dependent enzyme
TepiRe1_2280	COG0254	rRNA binding
TepiRe1_2284	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TepiRe1_2287	COG3885	ferrous iron binding
TepiRe1_2287	COG2078	PFAM AMMECR1 domain protein
TepiRe1_2289	COG5322	oxidoreductase activity
TepiRe1_2289	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TepiRe1_2293	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TepiRe1_2294	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TepiRe1_2300	COG3835	regulator
TepiRe1_2301	COG0840	transmembrane signaling receptor activity
TepiRe1_2304	COG1929	Belongs to the glycerate kinase type-1 family
TepiRe1_2305	COG1070	Carbohydrate kinase
TepiRe1_2306	COG2610	gluconate transmembrane transporter activity
TepiRe1_2308	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TepiRe1_2309	COG1737	Transcriptional regulator
TepiRe1_2310	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TepiRe1_2311	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TepiRe1_2313	COG1028	Short-chain dehydrogenase reductase Sdr
TepiRe1_2315	COG0037	tRNA processing
TepiRe1_2320	COG0463	Glycosyl transferase, family 2
TepiRe1_2322	COG0071	Belongs to the small heat shock protein (HSP20) family
TepiRe1_2324	COG0222	ribosome binding
TepiRe1_2325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TepiRe1_2327	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TepiRe1_2328	COG0250	Participates in transcription elongation, termination and antitermination
TepiRe1_2329	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TepiRe1_2330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TepiRe1_2334	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TepiRe1_2336	COG3688	RNA-binding protein containing a PIN domain
TepiRe1_2337	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TepiRe1_2339	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TepiRe1_2340	COG0215	cysteine-tRNA ligase activity
TepiRe1_2341	COG1045	serine acetyltransferase
TepiRe1_2342	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TepiRe1_2343	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TepiRe1_2344	COG4956	integral membrane protein (PIN domain superfamily)
TepiRe1_2345	COG1329	Transcriptional regulator
TepiRe1_2347	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TepiRe1_2348	COG0542	response to heat
TepiRe1_2349	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TepiRe1_2350	COG3880	PFAM UvrB UvrC protein
TepiRe1_2353	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TepiRe1_2354	COG0517	IMP dehydrogenase activity
TepiRe1_2354	COG0516	GMP reductase activity
TepiRe1_2356	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TepiRe1_2356	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TepiRe1_2357	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TepiRe1_2358	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TepiRe1_2361	COG1486	melibiose metabolic process
TepiRe1_2362	COG1435	thymidine kinase activity
TepiRe1_2367	COG1752	Esterase of the alpha-beta hydrolase superfamily
TepiRe1_2368	COG1013	pyruvate-flavodoxin oxidoreductase activity
TepiRe1_2369	COG0674	pyruvate-flavodoxin oxidoreductase activity
TepiRe1_2370	COG1144	Oxidoreductase
TepiRe1_2371	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TepiRe1_2378	COG1850	ribulose-bisphosphate carboxylase activity
TepiRe1_2380	COG1070	Carbohydrate kinase
TepiRe1_2381	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TepiRe1_2383	COG0446	pyridine nucleotide-disulphide oxidoreductase
TepiRe1_2384	COG0579	oxidoreductase
TepiRe1_2386	COG0698	ribose 5-phosphate isomerase
TepiRe1_2387	COG1349	DNA-binding transcription factor activity
TepiRe1_2388	COG1461	Dihydroxyacetone kinase
TepiRe1_2389	COG2376	Dihydroxyacetone kinase
TepiRe1_2390	COG0517	IMP dehydrogenase activity
TepiRe1_2390	COG0516	GMP reductase activity
TepiRe1_2393	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TepiRe1_2394	COG2814	Major facilitator Superfamily
TepiRe1_2396	COG0280	phosphate acetyltransferase
TepiRe1_2403	COG0655	NAD(P)H dehydrogenase (quinone) activity
TepiRe1_2407	COG1131	(ABC) transporter
TepiRe1_2408	COG0640	Transcriptional regulator
TepiRe1_2410	COG2203	Gaf domain
TepiRe1_2410	COG2199	diguanylate cyclase activity
TepiRe1_2412	COG1447	Phosphotransferase system cellobiose-specific component IIA
TepiRe1_2414	COG1446	asparaginase
TepiRe1_2415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TepiRe1_2417	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TepiRe1_2420	COG3711	transcriptional antiterminator
TepiRe1_2421	COG0720	synthase
TepiRe1_2422	COG1469	GTP cyclohydrolase I activity
TepiRe1_2423	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TepiRe1_2424	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TepiRe1_2424	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TepiRe1_2425	COG2723	6-phospho-beta-galactosidase activity
TepiRe1_2426	COG1902	pentaerythritol trinitrate reductase activity
TepiRe1_2426	COG0446	pyridine nucleotide-disulphide oxidoreductase
TepiRe1_2427	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TepiRe1_2430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TepiRe1_2430	COG3711	transcriptional antiterminator
TepiRe1_2442	COG3875	lactate racemase activity
TepiRe1_2445	COG3052	prosthetic group binding
TepiRe1_2447	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TepiRe1_2448	COG0473	3-isopropylmalate dehydrogenase activity
TepiRe1_2450	COG2828	Protein conserved in bacteria
TepiRe1_2452	COG0583	DNA-binding transcription factor activity
TepiRe1_2459	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TepiRe1_2463	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TepiRe1_2464	COG2610	gluconate transmembrane transporter activity
TepiRe1_2465	COG3290	protein histidine kinase activity
TepiRe1_2465	COG3829	transcription factor binding
TepiRe1_2511	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TepiRe1_2512	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TepiRe1_2513	COG0590	tRNA wobble adenosine to inosine editing
TepiRe1_2514	COG1247	-acetyltransferase
TepiRe1_2515	COG0726	polysaccharide deacetylase
TepiRe1_2516	COG1550	Protein conserved in bacteria
TepiRe1_2519	COG0765	amino acid transport
TepiRe1_2520	COG2423	ornithine cyclodeaminase activity
TepiRe1_2523	COG0733	neurotransmitter:sodium symporter activity
TepiRe1_2524	COG3033	Beta-eliminating lyase
TepiRe1_2525	COG3290	protein histidine kinase activity
TepiRe1_2525	COG3829	transcription factor binding
TepiRe1_2530	COG2186	Transcriptional regulator
TepiRe1_2531	COG1620	l-lactate permease
TepiRe1_2532	COG2086	electron transfer activity
TepiRe1_2533	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TepiRe1_2534	COG0277	FAD linked oxidase domain protein
TepiRe1_2537	COG1595	DNA-templated transcription, initiation
TepiRe1_2539	COG4176	ABC-type proline glycine betaine transport system permease component
TepiRe1_2543	COG0726	polysaccharide deacetylase
TepiRe1_2545	COG0531	amino acid
TepiRe1_2546	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TepiRe1_2548	COG1917	Cupin 2, conserved barrel domain protein
TepiRe1_2548	COG1396	sequence-specific DNA binding
TepiRe1_2550	COG0840	transmembrane signaling receptor activity
TepiRe1_2572	COG3077	Addiction module antitoxin, RelB DinJ family
TepiRe1_2583	COG5464	transposase or invertase
TepiRe1_2585	COG4974	Belongs to the 'phage' integrase family
TepiRe1_2586	COG0860	N-Acetylmuramoyl-L-alanine amidase
TepiRe1_2587	COG4824	toxin secretion phage lysis holin
TepiRe1_2604	COG0740	serine-type endopeptidase activity
TepiRe1_2606	COG1802	Transcriptional regulator
TepiRe1_2606	COG4626	Terminase
TepiRe1_2613	COG3077	Addiction module antitoxin, RelB DinJ family
TepiRe1_2614	COG3041	Addiction module toxin RelE StbE family
TepiRe1_2622	COG4133	protoheme IX ABC transporter activity
TepiRe1_2626	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TepiRe1_2626	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TepiRe1_2639	COG0497	DNA recombination
TepiRe1_2641	COG1067	ATP-dependent peptidase activity
TepiRe1_2642	COG2348	transferase activity, transferring amino-acyl groups
TepiRe1_2644	COG0504	CTP synthase activity
TepiRe1_2645	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TepiRe1_2647	COG0018	arginyl-trna synthetase
TepiRe1_2649	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TepiRe1_2650	COG0284	orotidine-5'-phosphate decarboxylase activity
TepiRe1_2651	COG0167	dihydroorotate dehydrogenase activity
TepiRe1_2652	COG0543	2 iron, 2 sulfur cluster binding
TepiRe1_2654	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TepiRe1_2655	COG0540	Belongs to the ATCase OTCase family
TepiRe1_2658	COG1605	Chorismate mutase
TepiRe1_2658	COG0077	Prephenate dehydratase
TepiRe1_2659	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TepiRe1_2660	COG0287	Prephenate dehydrogenase
TepiRe1_2661	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TepiRe1_2662	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TepiRe1_2663	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TepiRe1_2665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TepiRe1_2666	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TepiRe1_2667	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TepiRe1_2668	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TepiRe1_2670	COG3409	Peptidoglycan-binding domain 1 protein
TepiRe1_2670	COG3773	Cell wall hydrolase
TepiRe1_2672	COG1982	Orn Lys Arg decarboxylase major
TepiRe1_2677	COG3830	Belongs to the UPF0237 family
TepiRe1_2685	COG2059	Chromate
TepiRe1_2686	COG2059	Chromate
TepiRe1_2687	COG1115	amino acid carrier protein
TepiRe1_2692	COG0534	Mate efflux family protein
TepiRe1_2693	COG2207	Transcriptional regulator
TepiRe1_2693	COG1917	Cupin 2, conserved barrel domain protein
TepiRe1_2697	COG0514	ATP-dependent DNA helicase (RecQ)
TepiRe1_2702	COG1388	LysM domain
TepiRe1_2712	COG1215	transferase activity, transferring glycosyl groups
TepiRe1_2717	COG0440	acetolactate synthase activity
TepiRe1_2720	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TepiRe1_2723	COG2201	protein-glutamate methylesterase activity
TepiRe1_2725	COG2197	response regulator
TepiRe1_2726	COG0835	chemotaxis
TepiRe1_2726	COG0784	Response regulator, receiver
TepiRe1_2729	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TepiRe1_2730	COG1802	Transcriptional regulator
TepiRe1_2731	COG0840	transmembrane signaling receptor activity
TepiRe1_2732	COG4251	negative regulation of phosphorylation
TepiRe1_2734	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TepiRe1_2734	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TepiRe1_2735	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TepiRe1_2735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TepiRe1_2736	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TepiRe1_2737	COG3715	PTS system
TepiRe1_2738	COG3716	PTS system mannose fructose sorbose family IID component
TepiRe1_2739	COG1063	alcohol dehydrogenase
TepiRe1_2742	COG0446	pyridine nucleotide-disulphide oxidoreductase
TepiRe1_2744	COG0840	transmembrane signaling receptor activity
TepiRe1_2749	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TepiRe1_2750	COG1307	EDD domain protein, DegV family
TepiRe1_2753	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TepiRe1_2759	COG1671	Belongs to the UPF0178 family
TepiRe1_2763	COG1408	metallophosphoesterase
TepiRe1_2765	COG0708	Exodeoxyribonuclease III
TepiRe1_2769	COG0425	Belongs to the sulfur carrier protein TusA family
TepiRe1_2769	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TepiRe1_2770	COG2391	methyltransferase activity
TepiRe1_2771	COG0583	DNA-binding transcription factor activity
TepiRe1_2776	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TepiRe1_2776	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TepiRe1_2776	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TepiRe1_2777	COG1105	Belongs to the carbohydrate kinase PfkB family
TepiRe1_2778	COG1349	DNA-binding transcription factor activity
TepiRe1_2779	COG1151	hydroxylamine reductase activity
TepiRe1_2782	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TepiRe1_2785	COG3177	Filamentation induced by cAMP protein fic
TepiRe1_2798	COG0646	methionine synthase
TepiRe1_2798	COG1410	methionine synthase
TepiRe1_2800	COG0765	amino acid transport
TepiRe1_2801	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TepiRe1_2803	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TepiRe1_2808	COG5002	protein histidine kinase activity
TepiRe1_2809	COG0745	RESPONSE REGULATOR receiver
TepiRe1_2814	COG0739	heme binding
TepiRe1_2817	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TepiRe1_2820	COG0305	Participates in initiation and elongation during chromosome replication
TepiRe1_2822	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TepiRe1_2823	COG4241	membrane
TepiRe1_2826	COG0360	Binds together with S18 to 16S ribosomal RNA
TepiRe1_2828	COG4481	Protein conserved in bacteria
TepiRe1_2829	COG0668	transmembrane transport
TepiRe1_2832	COG3949	Membrane
TepiRe1_2835	COG4942	peptidase
TepiRe1_2835	COG1388	LysM domain
TepiRe1_2839	COG1943	Transposase
TepiRe1_2841	COG1475	DNA binding
TepiRe1_2842	COG1192	Involved in chromosome partitioning
TepiRe1_2845	COG0357	Ribosomal RNA small subunit methyltransferase G
TepiRe1_2846	COG0445	tRNA wobble uridine modification
TepiRe1_2847	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TepiRe1_2848	COG1847	R3H domain protein
TepiRe1_2849	COG0706	membrane insertase activity
TepiRe1_2850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TepiRe1_2851	COG0594	ribonuclease P activity
TepiRe1_2852	COG0230	Belongs to the bacterial ribosomal protein bL34 family