locus-tag	class	description
Tbon_00010	COG0589	response to stress
Tbon_00015	COG0569	domain protein
Tbon_00025	COG1605	Chorismate mutase
Tbon_00025	COG0077	Prephenate dehydratase
Tbon_00050	COG3608	succinylglutamate desuccinylase aspartoacylase
Tbon_00050	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tbon_00055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tbon_00080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tbon_00085	COG1024	Enoyl-CoA hydratase
Tbon_00095	COG0596	Alpha beta hydrolase
Tbon_00100	COG0596	Alpha beta hydrolase
Tbon_00120	COG0583	DNA-binding transcription factor activity
Tbon_00130	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tbon_00135	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tbon_00135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tbon_00140	COG0516	GMP reductase activity
Tbon_00140	COG0517	IMP dehydrogenase activity
Tbon_00175	COG0606	chelatase, subunit chli
Tbon_00180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tbon_00185	COG0124	histidyl-tRNA synthetase
Tbon_00190	COG0484	heat shock protein binding
Tbon_00210	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tbon_00215	COG0835	chemotaxis
Tbon_00220	COG2198	Histidine kinase
Tbon_00220	COG0643	Histidine kinase
Tbon_00230	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tbon_00235	COG2201	protein-glutamate methylesterase activity
Tbon_00240	COG2201	protein-glutamate methylesterase activity
Tbon_00245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tbon_00260	COG0427	acetyl-CoA hydrolase
Tbon_00265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_00270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_00275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tbon_00280	COG1960	acyl-CoA dehydrogenase activity
Tbon_00330	COG2267	carboxylic ester hydrolase activity
Tbon_00340	COG1193	negative regulation of DNA recombination
Tbon_00345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tbon_00375	COG0237	dephospho-CoA kinase activity
Tbon_00410	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Tbon_00415	COG1022	Amp-dependent synthetase and ligase
Tbon_00420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_00425	COG1960	acyl-CoA dehydrogenase activity
Tbon_00430	COG1215	transferase activity, transferring glycosyl groups
Tbon_00455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tbon_00465	COG1051	belongs to the nudix hydrolase family
Tbon_00480	COG4149	molybdate abc transporter
Tbon_00525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tbon_00545	COG0148	phosphopyruvate hydratase activity
Tbon_00550	COG0242	peptide deformylase activity
Tbon_00560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tbon_00565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tbon_00570	COG1201	RNA secondary structure unwinding
Tbon_00580	COG1733	regulation of RNA biosynthetic process
Tbon_00585	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Tbon_00590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_00630	COG1309	transcriptional regulator
Tbon_00640	COG1490	D-aminoacyl-tRNA deacylase activity
Tbon_00645	COG0442	prolyl-tRNA aminoacylation
Tbon_00665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tbon_00670	COG0538	isocitrate dehydrogenase activity
Tbon_00680	COG1199	ATP-dependent helicase activity
Tbon_00685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tbon_00705	COG1994	Peptidase M50
Tbon_00710	COG0287	Prephenate dehydrogenase
Tbon_00715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tbon_00725	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_00740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tbon_00780	COG0444	Belongs to the ABC transporter superfamily
Tbon_00785	COG4608	Belongs to the ABC transporter superfamily
Tbon_00795	COG0515	serine threonine protein kinase
Tbon_00795	COG2815	serine threonine protein kinase
Tbon_00805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tbon_00810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tbon_00815	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Tbon_00820	COG1077	Cell shape determining protein MreB Mrl
Tbon_00825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tbon_00830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tbon_00835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tbon_00840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tbon_00845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tbon_00850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tbon_00855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tbon_00860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tbon_00865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tbon_00870	COG0356	it plays a direct role in the translocation of protons across the membrane
Tbon_00895	COG0284	orotidine-5'-phosphate decarboxylase activity
Tbon_00900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tbon_00905	COG2045	Belongs to the ComB family
Tbon_00920	COG0714	Associated with various cellular activities
Tbon_00950	COG2096	Adenosyltransferase
Tbon_00955	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_00965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tbon_00970	COG0484	heat shock protein binding
Tbon_00980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tbon_00985	COG0540	Belongs to the ATCase OTCase family
Tbon_00990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tbon_00995	COG0505	Belongs to the CarA family
Tbon_01005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tbon_01010	COG0543	2 iron, 2 sulfur cluster binding
Tbon_01015	COG1058	Belongs to the CinA family
Tbon_01015	COG1546	Belongs to the CinA family
Tbon_01020	COG0384	phenazine biosynthesis protein PhzF
Tbon_01030	COG0318	PFAM AMP-dependent synthetase and ligase
Tbon_01035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tbon_01040	COG0569	domain protein
Tbon_01060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tbon_01085	COG0668	transmembrane transport
Tbon_01095	COG0129	dihydroxy-acid dehydratase activity
Tbon_01105	COG4770	biotin carboxylase activity
Tbon_01135	COG0489	protein tyrosine kinase activity
Tbon_01165	COG1846	Transcriptional regulator
Tbon_01180	COG0667	Aldo Keto reductase
Tbon_01190	COG0166	Belongs to the GPI family
Tbon_01205	COG2897	thiosulfate sulfurtransferase activity
Tbon_01210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tbon_01215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tbon_01235	COG4797	methyltransferase
Tbon_01235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tbon_01240	COG0436	Aminotransferase
Tbon_01255	COG1042	CoA-binding domain protein
Tbon_01255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tbon_01255	COG0045	succinate-CoA ligase (ADP-forming) activity
Tbon_01265	COG2197	response regulator
Tbon_01270	COG0424	maF-like protein
Tbon_01275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tbon_01300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tbon_01310	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_01315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_01320	COG2226	methyltransferase
Tbon_01335	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Tbon_01350	COG0321	lipoyl(octanoyl) transferase activity
Tbon_01355	COG0217	transcriptional regulatory protein
Tbon_01390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tbon_01395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tbon_01405	COG0250	Participates in transcription elongation, termination and antitermination
Tbon_01415	COG0601	transmembrane transport
Tbon_01425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tbon_01430	COG0081	regulation of translation
Tbon_01465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tbon_01470	COG0644	oxidoreductase
Tbon_01480	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_01485	COG0328	RNA-DNA hybrid ribonuclease activity
Tbon_01495	COG0497	DNA recombination
Tbon_01500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tbon_01505	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tbon_01510	COG0028	Belongs to the TPP enzyme family
Tbon_01515	COG0339	signal peptide processing
Tbon_01545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tbon_01550	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tbon_01555	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tbon_01560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tbon_01570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tbon_01575	COG1194	a g-specific adenine glycosylase
Tbon_01590	COG1228	amidohydrolase
Tbon_01610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tbon_01630	COG1136	(ABC) transporter
Tbon_01630	COG4591	ABC-type transport system involved in lipoprotein release permease component
Tbon_01635	COG0577	efflux transmembrane transporter activity
Tbon_01635	COG1136	(ABC) transporter
Tbon_01660	COG0196	riboflavin kinase activity
Tbon_01665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tbon_01700	COG0243	molybdopterin cofactor binding
Tbon_01730	COG1397	ADP-ribosylglycohydrolase
Tbon_01735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tbon_01745	COG4770	biotin carboxylase activity
Tbon_01790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tbon_01795	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_01805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tbon_01810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tbon_01815	COG0805	protein transport
Tbon_01825	COG1573	uracil-dna glycosylase
Tbon_01830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tbon_01835	COG1674	ftsk spoiiie
Tbon_01840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Tbon_01840	COG0825	malonyl-CoA metabolic process
Tbon_01845	COG0730	response to heat
Tbon_01855	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Tbon_01870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tbon_01875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tbon_01885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tbon_01910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tbon_01920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tbon_01925	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tbon_01930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tbon_01935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tbon_01940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tbon_01945	COG0772	Belongs to the SEDS family
Tbon_01955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tbon_01960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tbon_01965	COG0768	penicillin binding
Tbon_01975	COG0275	rRNA processing
Tbon_01980	COG2001	Belongs to the MraZ family
Tbon_01985	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tbon_01990	COG0336	Belongs to the RNA methyltransferase TrmD family
Tbon_02005	COG0577	efflux transmembrane transporter activity
Tbon_02010	COG1136	(ABC) transporter
Tbon_02015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tbon_02025	COG1959	2 iron, 2 sulfur cluster binding
Tbon_02025	COG1295	ribonuclease BN
Tbon_02035	COG0396	ATPase activity
Tbon_02040	COG0719	Fe-S assembly protein
Tbon_02045	COG0719	Fe-S assembly protein
Tbon_02055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tbon_02060	COG0822	iron-sulfur transferase activity
Tbon_02065	COG2151	metal-sulfur cluster biosynthetic enzyme
Tbon_02070	COG1024	Enoyl-CoA hydratase
Tbon_02090	COG1024	Enoyl-CoA hydratase
Tbon_02095	COG0517	IMP dehydrogenase activity
Tbon_02095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Tbon_02110	COG0582	viral genome integration into host DNA
Tbon_02115	COG1525	nuclease
Tbon_02165	COG1484	DNA-dependent DNA replication
Tbon_02280	COG0739	heme binding
Tbon_02330	COG0493	'glutamate synthase
Tbon_02330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tbon_02350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_02370	COG1024	Enoyl-CoA hydratase
Tbon_02375	COG1560	Kdo2-lipid A biosynthetic process
Tbon_02385	COG0613	PHP domain protein
Tbon_02390	COG0438	transferase activity, transferring glycosyl groups
Tbon_02395	COG1213	nucleotidyl transferase
Tbon_02395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tbon_02415	COG1960	acyl-CoA dehydrogenase activity
Tbon_02420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tbon_02430	COG0673	inositol 2-dehydrogenase activity
Tbon_02450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tbon_02455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tbon_02475	COG0085	RNA polymerase activity
Tbon_02505	COG0542	response to heat
Tbon_02510	COG0539	negative regulation of cytoplasmic translation
Tbon_02530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tbon_02535	COG0193	aminoacyl-tRNA hydrolase activity
Tbon_02555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tbon_02565	COG2084	Dehydrogenase
Tbon_02570	COG3706	GGDEF domain
Tbon_02570	COG0745	RESPONSE REGULATOR receiver
Tbon_02575	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_02590	COG2723	6-phospho-beta-galactosidase activity
Tbon_02595	COG0386	Belongs to the glutathione peroxidase family
Tbon_02605	COG1940	carbohydrate kinase activity
Tbon_02610	COG0412	Dienelactone hydrolase
Tbon_02620	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Tbon_02630	COG1678	Uncharacterized ACR, COG1678
Tbon_02640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_02655	COG1187	pseudouridine synthase activity
Tbon_02670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tbon_02680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tbon_02725	COG0183	Belongs to the thiolase family
Tbon_02735	COG0628	permease
Tbon_02745	COG0440	acetolactate synthase activity
Tbon_02750	COG0028	Belongs to the TPP enzyme family
Tbon_02760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tbon_02765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tbon_02780	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tbon_02790	COG0159	tryptophan synthase activity
Tbon_02805	COG0133	tryptophan synthase activity
Tbon_02815	COG0134	indole-3-glycerol-phosphate synthase activity
Tbon_02820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tbon_02825	COG0512	Glutamine amidotransferase of anthranilate synthase
Tbon_02835	COG0546	phosphoglycolate phosphatase activity
Tbon_02855	COG0180	Tryptophanyl-tRNA synthetase
Tbon_02870	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tbon_02885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Tbon_02895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tbon_02895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tbon_02900	COG0372	Belongs to the citrate synthase family
Tbon_02915	COG0802	atpase or kinase
Tbon_02920	COG1214	PFAM Peptidase M22, glycoprotease
Tbon_02925	COG0105	UTP biosynthetic process
Tbon_02935	COG1473	amidohydrolase
Tbon_02970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tbon_02980	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_03000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tbon_03010	COG0747	negative chemotaxis
Tbon_03020	COG1305	Transglutaminase-like
Tbon_03030	COG0714	Associated with various cellular activities
Tbon_03035	COG1309	transcriptional regulator
Tbon_03040	COG2409	Drug exporters of the RND superfamily
Tbon_03045	COG1960	acyl-CoA dehydrogenase activity
Tbon_03080	COG0456	acetyltransferase
Tbon_03095	COG0789	Transcriptional regulator
Tbon_03100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tbon_03120	COG0673	inositol 2-dehydrogenase activity
Tbon_03125	COG0546	phosphoglycolate phosphatase activity
Tbon_03135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_03155	COG0778	Nitroreductase
Tbon_03170	COG0012	GTP binding
Tbon_03195	COG0747	negative chemotaxis
Tbon_03200	COG0601	transmembrane transport
Tbon_03205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tbon_03230	COG2030	dehydratase
Tbon_03240	COG2124	cytochrome p450
Tbon_03245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tbon_03250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tbon_03260	COG2132	Multicopper oxidase
Tbon_03280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tbon_03355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tbon_03360	COG0066	3-isopropylmalate dehydratase activity
Tbon_03370	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Tbon_03380	COG0473	3-isopropylmalate dehydrogenase activity
Tbon_03385	COG1063	alcohol dehydrogenase
Tbon_03405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tbon_03410	COG0717	Belongs to the dCTP deaminase family
Tbon_03415	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tbon_03420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_03430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_03445	COG1862	Preprotein translocase
Tbon_03450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tbon_03455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tbon_03480	COG1122	ATPase activity
Tbon_03505	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tbon_03535	COG0681	Belongs to the peptidase S26 family
Tbon_03540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tbon_03595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_03610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tbon_03620	COG0438	transferase activity, transferring glycosyl groups
Tbon_03645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbon_03650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tbon_03675	COG0367	asparagine synthase
Tbon_03680	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_03695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tbon_03700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tbon_03705	COG1116	anion transmembrane transporter activity
Tbon_03720	COG4106	trans-aconitate 2-methyltransferase activity
Tbon_03735	COG0277	FAD linked oxidase domain protein
Tbon_03740	COG0277	FAD linked oxidase domain protein
Tbon_03745	COG0247	lactate metabolic process
Tbon_03750	COG3706	GGDEF domain
Tbon_03770	COG5549	protein import
Tbon_03770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbon_03775	COG0686	Belongs to the AlaDH PNT family
Tbon_03790	COG2111	Na H antiporter
Tbon_03805	COG1863	multisubunit Na H antiporter MnhE subunit
Tbon_03810	COG2212	antiporter activity
Tbon_03815	COG1320	monovalent cation:proton antiporter activity
Tbon_03835	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_03840	COG1024	Enoyl-CoA hydratase
Tbon_03845	COG2226	methyltransferase
Tbon_03850	COG0416	fatty acid biosynthetic process
Tbon_03885	COG1597	lipid kinase activity
Tbon_03890	COG0183	Belongs to the thiolase family
Tbon_03895	COG2072	flavoprotein involved in K transport
Tbon_03950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tbon_03975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbon_03990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tbon_04010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tbon_04015	COG0357	Ribosomal RNA small subunit methyltransferase G
Tbon_04045	COG1104	cysteine desulfurase activity
Tbon_04070	COG1494	fructose-1,6-bisphosphatase
Tbon_04085	COG1120	ATPase activity
Tbon_04090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tbon_04115	COG1960	acyl-CoA dehydrogenase activity
Tbon_04125	COG4691	Plasmid stability protein
Tbon_04135	COG1024	Enoyl-CoA hydratase
Tbon_04140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tbon_04145	COG4786	Flagellar basal body rod
Tbon_04145	COG1256	bacterial-type flagellum assembly
Tbon_04165	COG4786	Flagellar basal body rod
Tbon_04180	COG1191	sigma factor activity
Tbon_04200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tbon_04205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tbon_04210	COG1684	flagellar biosynthetic protein fliR
Tbon_04215	COG1987	bacterial-type flagellum assembly
Tbon_04220	COG1338	Plays a role in the flagellum-specific transport system
Tbon_04230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tbon_04230	COG1776	CheC inhibitor of MCP methylation
Tbon_04245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Tbon_04270	COG4552	Acetyltransferase involved in intracellular survival and related
Tbon_04275	COG0612	Peptidase, M16
Tbon_04285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tbon_04300	COG1595	DNA-templated transcription, initiation
Tbon_04310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tbon_04350	COG0517	IMP dehydrogenase activity
Tbon_04350	COG1994	Peptidase M50
Tbon_04355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tbon_04360	COG3608	succinylglutamate desuccinylase aspartoacylase
Tbon_04360	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tbon_04365	COG0588	phosphoglycerate mutase activity
Tbon_04380	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_04390	COG1024	Enoyl-CoA hydratase
Tbon_04400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_04410	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tbon_04430	COG1253	flavin adenine dinucleotide binding
Tbon_04435	COG1132	(ABC) transporter
Tbon_04440	COG1132	(ABC) transporter
Tbon_04450	COG0500	methyltransferase
Tbon_04455	COG0187	DNA topoisomerase II activity
Tbon_04465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tbon_04495	COG2326	polyphosphate kinase activity
Tbon_04500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tbon_04510	COG0460	homoserine dehydrogenase
Tbon_04520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tbon_04530	COG0360	Binds together with S18 to 16S ribosomal RNA
Tbon_04535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tbon_04555	COG1024	Enoyl-CoA hydratase
Tbon_04560	COG2353	YceI-like domain
Tbon_04575	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_04585	COG1024	Enoyl-CoA hydratase
Tbon_04615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tbon_04645	COG2267	carboxylic ester hydrolase activity
Tbon_04655	COG0681	Belongs to the peptidase S26 family
Tbon_04660	COG1024	Enoyl-CoA hydratase
Tbon_04665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tbon_04670	COG0222	ribosome binding
Tbon_04675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Tbon_04675	COG4651	solute:proton antiporter activity
Tbon_04680	COG1063	alcohol dehydrogenase
Tbon_04685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tbon_04695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tbon_04705	COG2204	response regulator
Tbon_04710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tbon_04725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tbon_04740	COG1595	DNA-templated transcription, initiation
Tbon_04745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tbon_04790	COG0616	signal peptide processing
Tbon_04825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Tbon_04830	COG0318	PFAM AMP-dependent synthetase and ligase
Tbon_04835	COG1024	Enoyl-CoA hydratase
Tbon_04850	COG4867	von Willebrand factor, type A
Tbon_04855	COG2197	response regulator
Tbon_04875	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tbon_04880	COG0473	3-isopropylmalate dehydrogenase activity
Tbon_04900	COG0792	nuclease activity
Tbon_04905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tbon_04910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tbon_04930	COG2267	carboxylic ester hydrolase activity
Tbon_04960	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_04965	COG0484	heat shock protein binding
Tbon_04970	COG2264	protein methyltransferase activity
Tbon_04985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tbon_04990	COG0174	glutamine synthetase
Tbon_05010	COG0492	ferredoxin-NADP+ reductase activity
Tbon_05015	COG3118	belongs to the thioredoxin family
Tbon_05020	COG1937	Protein conserved in bacteria
Tbon_05025	COG1929	Belongs to the glycerate kinase type-1 family
Tbon_05050	COG2414	aldehyde ferredoxin oxidoreductase
Tbon_05060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Tbon_05075	COG3852	Histidine kinase
Tbon_05090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tbon_05095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_05105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Tbon_05120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_05125	COG1410	methionine synthase
Tbon_05125	COG0646	methionine synthase
Tbon_05150	COG0456	acetyltransferase
Tbon_05150	COG1214	PFAM Peptidase M22, glycoprotease
Tbon_05160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tbon_05165	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tbon_05180	COG0596	Alpha beta hydrolase
Tbon_05180	COG2945	thiolester hydrolase activity
Tbon_05185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tbon_05210	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tbon_05215	COG1518	maintenance of DNA repeat elements
Tbon_05215	COG1468	defense response to virus
Tbon_05320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tbon_05340	COG2124	cytochrome p450
Tbon_05385	COG0270	DNA (cytosine-5-)-methyltransferase activity
Tbon_05405	COG1960	acyl-CoA dehydrogenase activity
Tbon_05410	COG0561	phosphatase activity
Tbon_05440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_05450	COG1132	(ABC) transporter
Tbon_05455	COG1132	(ABC) transporter
Tbon_05460	COG1333	cytochrome c biogenesis protein
Tbon_05465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbon_05475	COG1111	helicase
Tbon_05475	COG1205	dead DEAH box helicase
Tbon_05490	COG0138	bifunctional purine biosynthesis protein purh
Tbon_05495	COG0494	nUDIX hydrolase
Tbon_05515	COG1309	transcriptional regulator
Tbon_05520	COG0183	Belongs to the thiolase family
Tbon_05530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbon_05535	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tbon_05540	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Tbon_05550	COG0747	negative chemotaxis
Tbon_05570	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Tbon_05575	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_05580	COG0483	inositol monophosphate 1-phosphatase activity
Tbon_05585	COG3386	PFAM SMP-30 Gluconolaconase
Tbon_05590	COG0443	Heat shock 70 kDa protein
Tbon_05595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tbon_05600	COG1420	regulation of RNA biosynthetic process
Tbon_05620	COG0071	Belongs to the small heat shock protein (HSP20) family
Tbon_05645	COG1999	signal sequence binding
Tbon_05660	COG0300	oxidoreductase activity
Tbon_05665	COG0588	phosphoglycerate mutase activity
Tbon_05670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tbon_05675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tbon_05680	COG0601	transmembrane transport
Tbon_05685	COG0747	negative chemotaxis
Tbon_05715	COG3852	Histidine kinase
Tbon_05720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tbon_05750	COG1104	cysteine desulfurase activity
Tbon_05755	COG0527	aspartate kinase activity
Tbon_05770	COG2124	cytochrome p450
Tbon_05775	COG0135	phosphoribosylanthranilate isomerase activity
Tbon_05780	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Tbon_05785	COG0484	heat shock protein binding
Tbon_05805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tbon_05815	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Tbon_05835	COG0745	RESPONSE REGULATOR receiver
Tbon_05840	COG5002	protein histidine kinase activity
Tbon_05860	COG0459	protein refolding
Tbon_05865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tbon_05885	COG1024	Enoyl-CoA hydratase
Tbon_05905	COG0598	Magnesium transport protein CorA
Tbon_05915	COG1595	DNA-templated transcription, initiation
Tbon_05950	COG1045	serine acetyltransferase
Tbon_05955	COG0019	diaminopimelate decarboxylase activity
Tbon_05960	COG0745	RESPONSE REGULATOR receiver
Tbon_05970	COG1797	cobyrinic acid a,c-diamide synthase activity
Tbon_05990	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tbon_05995	COG0724	RNA recognition motif
Tbon_06000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tbon_06005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tbon_06010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tbon_06020	COG0215	cysteine-tRNA ligase activity
Tbon_06040	COG2119	membrane
Tbon_06075	COG0488	(ABC) transporter
Tbon_06080	COG0277	FAD linked oxidase domain protein
Tbon_06090	COG1803	Methylglyoxal synthase
Tbon_06090	COG1597	lipid kinase activity
Tbon_06105	COG0745	RESPONSE REGULATOR receiver
Tbon_06105	COG3706	GGDEF domain
Tbon_06130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tbon_06175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tbon_06190	COG0500	methyltransferase
Tbon_06210	COG1024	Enoyl-CoA hydratase
Tbon_06225	COG3842	ATPase activity
Tbon_06230	COG1178	ABC-type Fe3 transport system permease component
Tbon_06240	COG0592	DNA-directed DNA polymerase activity
Tbon_06250	COG1881	PFAM PEBP family protein
Tbon_06265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Tbon_06285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tbon_06305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tbon_06340	COG0411	ABC transporter
Tbon_06370	COG1575	Belongs to the MenA family. Type 1 subfamily
Tbon_06375	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tbon_06390	COG0556	nucleotide-excision repair
Tbon_06400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Tbon_06415	COG1024	Enoyl-CoA hydratase
Tbon_06420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tbon_06425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tbon_06435	COG0574	Belongs to the PEP-utilizing enzyme family
Tbon_06435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tbon_06455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tbon_06470	COG1404	Belongs to the peptidase S8 family
Tbon_06485	COG2894	cell division
Tbon_06490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tbon_06495	COG0739	heme binding
Tbon_06495	COG1196	nuclear chromosome segregation
Tbon_06495	COG0741	lytic transglycosylase activity
Tbon_06500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Tbon_06510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tbon_06525	COG1847	R3H domain protein
Tbon_06525	COG1847	R3H domain protein
Tbon_06535	COG1192	Involved in chromosome partitioning
Tbon_06540	COG1475	DNA binding
Tbon_06550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tbon_06555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tbon_06555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tbon_06570	COG1960	acyl-CoA dehydrogenase activity
Tbon_06610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_06640	COG3845	ABC transporter
Tbon_06655	COG1595	DNA-templated transcription, initiation
Tbon_06660	COG1215	transferase activity, transferring glycosyl groups
Tbon_06720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tbon_06745	COG0281	malic enzyme
Tbon_06760	COG1832	CoA-binding protein
Tbon_06765	COG0183	Belongs to the thiolase family
Tbon_06775	COG2003	Belongs to the UPF0758 family
Tbon_06780	COG3591	Belongs to the peptidase S1B family
Tbon_06795	COG0791	NLP P60 protein
Tbon_06795	COG1388	LysM domain
Tbon_06795	COG3103	Sh3 type 3 domain protein
Tbon_06800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tbon_06815	COG2814	Major facilitator Superfamily
Tbon_06830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tbon_06835	COG3854	ATPases associated with a variety of cellular activities
Tbon_06845	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Tbon_06850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tbon_06895	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tbon_06945	COG0617	tRNA 3'-terminal CCA addition
Tbon_06950	COG1231	oxidoreductase activity
Tbon_06960	COG0347	Belongs to the P(II) protein family
Tbon_06965	COG0004	ammonium transporteR
Tbon_06970	COG2086	electron transfer activity
Tbon_06975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Tbon_06990	COG1703	isobutyryl-CoA mutase activity
Tbon_06995	COG0438	transferase activity, transferring glycosyl groups
Tbon_07005	COG0659	secondary active sulfate transmembrane transporter activity
Tbon_07015	COG3706	GGDEF domain
Tbon_07045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tbon_07050	COG1774	PSP1 C-terminal conserved region
Tbon_07070	COG0667	Aldo Keto reductase
Tbon_07085	COG1575	Belongs to the MenA family. Type 1 subfamily
Tbon_07090	COG2226	methyltransferase
Tbon_07095	COG1215	transferase activity, transferring glycosyl groups
Tbon_07130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tbon_07135	COG1610	YqeY-like protein
Tbon_07140	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Tbon_07145	COG1480	7TM receptor with intracellular HD hydrolase
Tbon_07150	COG0047	phosphoribosylformylglycinamidine synthase activity
Tbon_07160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tbon_07165	COG1994	Peptidase M50
Tbon_07165	COG0517	IMP dehydrogenase activity
Tbon_07175	COG0768	penicillin binding
Tbon_07180	COG1024	Enoyl-CoA hydratase
Tbon_07185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tbon_07190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tbon_07195	COG1213	nucleotidyl transferase
Tbon_07195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tbon_07245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbon_07250	COG2181	nitrate reductase activity
Tbon_07250	COG0247	lactate metabolic process
Tbon_07255	COG0318	PFAM AMP-dependent synthetase and ligase
Tbon_07295	COG1735	metal-dependent hydrolase with the TIM-barrel fold
Tbon_07320	COG2267	carboxylic ester hydrolase activity
Tbon_07325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tbon_07340	COG2814	Major facilitator Superfamily
Tbon_07350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tbon_07360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tbon_07365	COG0724	RNA recognition motif
Tbon_07375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tbon_07385	COG2226	methyltransferase
Tbon_07400	COG1053	succinate dehydrogenase
Tbon_07415	COG0482	sulfurtransferase activity
Tbon_07420	COG0799	negative regulation of ribosome biogenesis
Tbon_07425	COG1024	Enoyl-CoA hydratase
Tbon_07440	COG1234	tRNA 3'-trailer cleavage
Tbon_07450	COG0745	RESPONSE REGULATOR receiver
Tbon_07455	COG1733	regulation of RNA biosynthetic process
Tbon_07460	COG1388	LysM domain
Tbon_07465	COG0701	Predicted permease
Tbon_07475	COG0823	Involved in the tonB-independent uptake of proteins
Tbon_07500	COG1196	nuclear chromosome segregation
Tbon_07500	COG0739	heme binding
Tbon_07500	COG0741	lytic transglycosylase activity
Tbon_07510	COG0438	transferase activity, transferring glycosyl groups
Tbon_07520	COG0702	epimerase
Tbon_07545	COG2226	methyltransferase
Tbon_07560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tbon_07570	COG3191	aminopeptidase activity
Tbon_07575	COG0588	phosphoglycerate mutase activity
Tbon_07590	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Tbon_07605	COG2267	carboxylic ester hydrolase activity
Tbon_07610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tbon_07625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_07635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tbon_07635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tbon_07650	COG0601	transmembrane transport
Tbon_07660	COG2124	cytochrome p450
Tbon_07665	COG1960	acyl-CoA dehydrogenase activity
Tbon_07675	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_07685	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_07695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tbon_07700	COG0022	dehydrogenase e1 component
Tbon_07705	COG3199	ATP-NAD kinase
Tbon_07710	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbon_07725	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_07760	COG0427	acetyl-CoA hydrolase
Tbon_07770	COG2897	thiosulfate sulfurtransferase activity
Tbon_07780	COG0504	CTP synthase activity
Tbon_07790	COG0672	)-iron permease
Tbon_07820	COG0612	Peptidase, M16
Tbon_07825	COG0174	glutamine synthetase
Tbon_07835	COG2272	Belongs to the type-B carboxylesterase lipase family
Tbon_07870	COG1271	oxidase subunit
Tbon_07880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_07895	COG2267	carboxylic ester hydrolase activity
Tbon_07900	COG0739	heme binding
Tbon_07915	COG0300	oxidoreductase activity
Tbon_07920	COG0268	Binds directly to 16S ribosomal RNA
Tbon_07925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_07930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_07935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_07940	COG0649	NAD binding
Tbon_07945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tbon_07950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_07960	COG0713	ATP synthesis coupled electron transport
Tbon_07965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tbon_07970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_07975	COG1007	ATP synthesis coupled electron transport
Tbon_07985	COG0653	protein targeting
Tbon_08045	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Tbon_08055	COG0602	queuosine metabolic process
Tbon_08060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Tbon_08070	COG1959	2 iron, 2 sulfur cluster binding
Tbon_08105	COG1528	Iron-storage protein
Tbon_08110	COG1024	Enoyl-CoA hydratase
Tbon_08140	COG1234	tRNA 3'-trailer cleavage
Tbon_08175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tbon_08195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tbon_08210	COG1960	acyl-CoA dehydrogenase activity
Tbon_08250	COG1950	PFAM Membrane protein of
Tbon_08255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_08275	COG0542	response to heat
Tbon_08280	COG0789	Transcriptional regulator
Tbon_08285	COG0484	heat shock protein binding
Tbon_08290	COG0071	Belongs to the small heat shock protein (HSP20) family
Tbon_08300	COG2835	tetraacyldisaccharide 4'-kinase activity
Tbon_08305	COG1286	toxin biosynthetic process
Tbon_08330	COG0601	transmembrane transport
Tbon_08350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_08360	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Tbon_08385	COG0525	valine-tRNA ligase activity
Tbon_08405	COG0513	Belongs to the DEAD box helicase family
Tbon_08410	COG1024	Enoyl-CoA hydratase
Tbon_08425	COG0739	heme binding
Tbon_08425	COG0741	lytic transglycosylase activity
Tbon_08425	COG1196	nuclear chromosome segregation
Tbon_08435	COG0315	cyclic pyranopterin monophosphate synthase activity
Tbon_08440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tbon_08445	COG0459	protein refolding
Tbon_08455	COG1254	Belongs to the acylphosphatase family
Tbon_08465	COG0778	Nitroreductase
Tbon_08490	COG2318	DinB family
Tbon_08500	COG0473	3-isopropylmalate dehydrogenase activity
Tbon_08505	COG2814	Major facilitator Superfamily
Tbon_08510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_08515	COG1024	Enoyl-CoA hydratase
Tbon_08520	COG2271	Major facilitator Superfamily
Tbon_08540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tbon_08580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tbon_08585	COG1185	polyribonucleotide nucleotidyltransferase activity
Tbon_08610	COG1960	acyl-CoA dehydrogenase activity
Tbon_08615	COG3706	GGDEF domain
Tbon_08630	COG0469	pyruvate kinase activity
Tbon_08640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_08645	COG1960	acyl-CoA dehydrogenase activity
Tbon_08655	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tbon_08665	COG0667	Aldo Keto reductase
Tbon_08680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tbon_08680	COG1648	precorrin-2 dehydrogenase activity
Tbon_08690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tbon_08695	COG0181	hydroxymethylbilane synthase activity
Tbon_08700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tbon_08710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Tbon_08710	COG0392	lysyltransferase activity
Tbon_08720	COG2226	methyltransferase
Tbon_08730	COG0427	acetyl-CoA hydrolase
Tbon_08735	COG1024	Enoyl-CoA hydratase
Tbon_08765	COG0427	acetyl-CoA hydrolase
Tbon_08770	COG0415	Belongs to the DNA photolyase family
Tbon_08775	COG2239	Acts as a magnesium transporter
Tbon_08800	COG0704	Plays a role in the regulation of phosphate uptake
Tbon_08805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tbon_08810	COG0581	inorganic phosphate transmembrane transporter activity
Tbon_08815	COG0573	inorganic phosphate transmembrane transporter activity
Tbon_08820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tbon_08825	COG0745	RESPONSE REGULATOR receiver
Tbon_08830	COG5002	protein histidine kinase activity
Tbon_08855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tbon_08870	COG1045	serine acetyltransferase
Tbon_08885	COG1030	water channel activity
Tbon_08905	COG2255	four-way junction helicase activity
Tbon_08915	COG0531	amino acid
Tbon_08930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_08955	COG0359	binds to the 23S rRNA
Tbon_08960	COG0305	Participates in initiation and elongation during chromosome replication
Tbon_08985	COG0314	molybdopterin synthase activity
Tbon_08990	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Tbon_08995	COG0714	Associated with various cellular activities
Tbon_09030	COG1666	GTP binding
Tbon_09055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tbon_09060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_09070	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_09080	COG3287	FIST C domain
Tbon_09080	COG2199	diguanylate cyclase activity
Tbon_09080	COG2200	EAL domain
Tbon_09095	COG0302	gtp cyclohydrolase
Tbon_09120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tbon_09125	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tbon_09135	COG3345	alpha-galactosidase
Tbon_09155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_09165	COG1733	regulation of RNA biosynthetic process
Tbon_09170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbon_09175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tbon_09180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tbon_09200	COG0537	adenosine 5'-monophosphoramidase activity
Tbon_09210	COG1766	The M ring may be actively involved in energy transduction
Tbon_09215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tbon_09225	COG1157	protein secretion by the type III secretion system
Tbon_09245	COG1677	Flagellar hook-basal body complex protein FliE
Tbon_09255	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tbon_09285	COG1024	Enoyl-CoA hydratase
Tbon_09315	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbon_09320	COG0022	dehydrogenase e1 component
Tbon_09325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tbon_09330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tbon_09335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tbon_09340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tbon_09345	COG1595	DNA-templated transcription, initiation
Tbon_09365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tbon_09370	COG0049	tRNA binding
Tbon_09375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tbon_09380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tbon_09385	COG0051	transcription antitermination factor activity, RNA binding
Tbon_09390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tbon_09395	COG0088	Forms part of the polypeptide exit tunnel
Tbon_09400	COG0089	rRNA binding
Tbon_09405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tbon_09410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tbon_09415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tbon_09420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tbon_09435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tbon_09440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tbon_09445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tbon_09450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tbon_09455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tbon_09460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tbon_09465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tbon_09470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tbon_09475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tbon_09480	COG1841	ribosomal large subunit assembly
Tbon_09485	COG0200	Binds to the 23S rRNA
Tbon_09490	COG0201	protein transport
Tbon_09495	COG0563	adenylate kinase activity
Tbon_09505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tbon_09510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tbon_09520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tbon_09525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tbon_09530	COG0202	RNA polymerase activity
Tbon_09535	COG0203	ribosomal protein L17
Tbon_09545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tbon_09550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tbon_09570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tbon_09575	COG2304	oxidoreductase activity
Tbon_09585	COG0714	Associated with various cellular activities
Tbon_09595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_09670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tbon_09675	COG1121	(ABC) transporter
Tbon_09695	COG3852	Histidine kinase
Tbon_09720	COG0596	Alpha beta hydrolase
Tbon_09720	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbon_09725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tbon_09725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tbon_09750	COG0083	homoserine kinase activity
Tbon_09760	COG0765	amino acid transport
Tbon_09775	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_09790	COG0322	excinuclease ABC activity
Tbon_09815	COG1388	LysM domain
Tbon_09815	COG3942	CHAP domain
Tbon_09850	COG0596	Alpha beta hydrolase
Tbon_09855	COG2878	Part of a membrane complex involved in electron transport
Tbon_09860	COG2154	pterin-4-alpha-carbinolamine dehydratase
Tbon_09925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tbon_09930	COG1307	EDD domain protein, DegV family
Tbon_09935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tbon_09945	COG0772	Belongs to the SEDS family
Tbon_09950	COG0768	penicillin binding
Tbon_09960	COG1792	Involved in formation and maintenance of cell shape
Tbon_09975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tbon_09985	COG0107	imidazoleglycerol-phosphate synthase activity
Tbon_09990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tbon_09990	COG0140	phosphoribosyl-ATP diphosphatase activity
Tbon_10025	COG0604	alcohol dehydrogenase
Tbon_10030	COG0469	pyruvate kinase activity
Tbon_10040	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Tbon_10065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Tbon_10075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tbon_10080	COG0228	four-way junction DNA binding
Tbon_10090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tbon_10110	COG0583	DNA-binding transcription factor activity
Tbon_10115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tbon_10125	COG0393	Putative heavy-metal-binding
Tbon_10135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tbon_10165	COG1846	Transcriptional regulator
Tbon_10175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tbon_10190	COG0747	negative chemotaxis
Tbon_10195	COG0601	transmembrane transport
Tbon_10210	COG0740	serine-type endopeptidase activity
Tbon_10215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tbon_10235	COG0431	NADPH-dependent FMN reductase
Tbon_10240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tbon_10255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tbon_10260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tbon_10260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tbon_10285	COG0312	modulator of DNA gyrase
Tbon_10290	COG0312	modulator of DNA gyrase
Tbon_10300	COG0822	iron-sulfur transferase activity
Tbon_10310	COG0442	prolyl-tRNA aminoacylation
Tbon_10315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tbon_10320	COG0736	holo-[acyl-carrier-protein] synthase activity
Tbon_10325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tbon_10325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tbon_10330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbon_10335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tbon_10335	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Tbon_10345	COG4974	Belongs to the 'phage' integrase family
Tbon_10350	COG1960	acyl-CoA dehydrogenase activity
Tbon_10360	COG0248	Ppx GppA phosphatase
Tbon_10365	COG2062	phosphohistidine phosphatase, SixA
Tbon_10410	COG1353	crispr-associated protein
Tbon_10420	COG0210	DNA helicase
Tbon_10420	COG0210	DNA helicase
Tbon_10430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tbon_10450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tbon_10450	COG2199	diguanylate cyclase activity
Tbon_10480	COG0247	lactate metabolic process
Tbon_10485	COG1139	Iron-sulfur cluster binding protein
Tbon_10495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_10500	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_10530	COG0411	ABC transporter
Tbon_10550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_10555	COG2267	carboxylic ester hydrolase activity
Tbon_10560	COG3383	formate dehydrogenase (NAD+) activity
Tbon_10565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_10570	COG2814	Major facilitator Superfamily
Tbon_10575	COG0039	L-malate dehydrogenase activity
Tbon_10580	COG0481	GTPase activity
Tbon_10590	COG1957	nucleoside hydrolase
Tbon_10600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tbon_10605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tbon_10610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tbon_10615	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tbon_10625	COG1131	(ABC) transporter
Tbon_10635	COG0762	integral membrane protein
Tbon_10640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tbon_10655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tbon_10685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tbon_10690	COG1053	succinate dehydrogenase
Tbon_10700	COG0494	nUDIX hydrolase
Tbon_10715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tbon_10730	COG0237	dephospho-CoA kinase activity
Tbon_10760	COG2199	diguanylate cyclase activity
Tbon_10760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tbon_10765	COG1321	iron dependent repressor
Tbon_10770	COG1695	Transcriptional regulator
Tbon_10800	COG1215	transferase activity, transferring glycosyl groups
Tbon_10805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tbon_10835	COG3956	TIGRFAM MazG family protein
Tbon_10845	COG0297	glycogen (starch) synthase activity
Tbon_10860	COG0546	phosphoglycolate phosphatase activity
Tbon_10885	COG1570	exodeoxyribonuclease VII activity
Tbon_10890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tbon_10895	COG0006	proline dipeptidase activity
Tbon_10900	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tbon_10905	COG4974	Belongs to the 'phage' integrase family
Tbon_10910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tbon_10915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tbon_10915	COG0758	DNA mediated transformation
Tbon_10925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tbon_10940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tbon_10945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tbon_10950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tbon_10960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tbon_10965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tbon_10970	COG0343	queuine tRNA-ribosyltransferase activity
Tbon_11005	COG1492	cobalamin metabolic process
Tbon_11010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tbon_11015	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Tbon_11025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tbon_11035	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Tbon_11045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tbon_11050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_11055	COG0584	glycerophosphoryl diester phosphodiesterase
Tbon_11085	COG0831	urea catabolic process
Tbon_11095	COG0804	urea catabolic process
Tbon_11100	COG0830	nickel cation binding
Tbon_11105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Tbon_11120	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tbon_11150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tbon_11150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tbon_11155	COG1960	acyl-CoA dehydrogenase activity
Tbon_11160	COG1131	(ABC) transporter
Tbon_11175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_11190	COG3118	belongs to the thioredoxin family
Tbon_11195	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tbon_11200	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_11215	COG2195	Cleaves the N-terminal amino acid of tripeptides
Tbon_11230	COG0746	molybdenum cofactor guanylyltransferase activity
Tbon_11255	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbon_11260	COG0022	dehydrogenase e1 component
Tbon_11265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tbon_11270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tbon_11280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tbon_11290	COG0667	Aldo Keto reductase
Tbon_11300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tbon_11310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tbon_11310	COG3064	Membrane
Tbon_11315	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Tbon_11320	COG0195	Participates in both transcription termination and antitermination
Tbon_11330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tbon_11335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbon_11340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbon_11345	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tbon_11350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tbon_11370	COG0708	Exodeoxyribonuclease III
Tbon_11375	COG2814	Major facilitator Superfamily
Tbon_11410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tbon_11415	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Tbon_11425	COG1160	GTP binding
Tbon_11435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tbon_11460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tbon_11465	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tbon_11470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tbon_11480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tbon_11485	COG0151	Belongs to the GarS family
Tbon_11490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tbon_11490	COG0519	Catalyzes the synthesis of GMP from XMP
Tbon_11500	COG0698	ribose 5-phosphate isomerase
Tbon_11505	COG0126	phosphoglycerate kinase activity
Tbon_11515	COG0149	triose-phosphate isomerase activity
Tbon_11520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tbon_11530	COG0436	Aminotransferase
Tbon_11535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tbon_11540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_11545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_11555	COG1845	cytochrome c oxidase, subunit III
Tbon_11565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Tbon_11570	COG0109	protoheme IX farnesyltransferase activity
Tbon_11575	COG1612	heme a metabolic process
Tbon_11580	COG1196	nuclear chromosome segregation
Tbon_11580	COG0741	lytic transglycosylase activity
Tbon_11580	COG0739	heme binding
Tbon_11590	COG2030	dehydratase
Tbon_11620	COG0596	Alpha beta hydrolase
Tbon_11635	COG0745	RESPONSE REGULATOR receiver
Tbon_11685	COG0406	alpha-ribazole phosphatase activity
Tbon_11700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_11705	COG0483	inositol monophosphate 1-phosphatase activity
Tbon_11715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Tbon_11720	COG1331	Highly conserved protein containing a thioredoxin domain
Tbon_11750	COG1960	acyl-CoA dehydrogenase activity
Tbon_11760	COG1024	Enoyl-CoA hydratase
Tbon_11775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tbon_11805	COG1960	acyl-CoA dehydrogenase activity
Tbon_11835	COG2897	thiosulfate sulfurtransferase activity
Tbon_11840	COG0425	Belongs to the sulfur carrier protein TusA family
Tbon_11845	COG2391	methyltransferase activity
Tbon_11890	COG1205	dead DEAH box helicase
Tbon_11890	COG1111	helicase
Tbon_11895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tbon_11920	COG0582	viral genome integration into host DNA
Tbon_11955	COG1968	undecaprenyl-diphosphatase activity
Tbon_11960	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_11965	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_11990	COG0745	RESPONSE REGULATOR receiver
Tbon_12035	COG0423	glycine-tRNA ligase activity
Tbon_12040	COG1872	DUF167
Tbon_12045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tbon_12055	COG1960	acyl-CoA dehydrogenase activity
Tbon_12060	COG0768	penicillin binding
Tbon_12080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbon_12085	COG0205	6-phosphofructokinase activity
Tbon_12105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tbon_12125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tbon_12130	COG3872	metal-dependent enzyme
Tbon_12140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tbon_12145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tbon_12150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tbon_12160	COG2267	carboxylic ester hydrolase activity
Tbon_12165	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Tbon_12165	COG0778	Nitroreductase
Tbon_12185	COG0756	dUTP diphosphatase activity
Tbon_12190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tbon_12195	COG0335	large ribosomal subunit rRNA binding
Tbon_12200	COG0477	Major facilitator Superfamily
Tbon_12225	COG0564	pseudouridine synthase activity
Tbon_12230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tbon_12235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Tbon_12260	COG2197	response regulator
Tbon_12275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tbon_12285	COG2267	carboxylic ester hydrolase activity
Tbon_12290	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tbon_12295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Tbon_12300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tbon_12310	COG0006	proline dipeptidase activity
Tbon_12340	COG0398	Pfam SNARE associated Golgi protein
Tbon_12345	COG0596	Alpha beta hydrolase
Tbon_12350	COG0575	Belongs to the CDS family
Tbon_12360	COG0233	cytoplasmic translational termination
Tbon_12365	COG0528	UMP kinase activity
Tbon_12370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tbon_12375	COG0052	Belongs to the universal ribosomal protein uS2 family
Tbon_12380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Tbon_12380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Tbon_12385	COG0140	phosphoribosyl-ATP diphosphatase activity
Tbon_12390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tbon_12400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tbon_12405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tbon_12410	COG0131	Imidazoleglycerol-phosphate dehydratase
Tbon_12425	COG0494	nUDIX hydrolase
Tbon_12430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tbon_12435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tbon_12450	COG2070	2-Nitropropane dioxygenase
Tbon_12455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_12465	COG1704	LemA family
Tbon_12470	COG0501	Belongs to the peptidase M48B family
Tbon_12490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tbon_12500	COG0571	ribonuclease III activity
Tbon_12505	COG1196	nuclear chromosome segregation
Tbon_12510	COG0552	protein localization to endoplasmic reticulum
Tbon_12550	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tbon_12585	COG1960	acyl-CoA dehydrogenase activity
Tbon_12590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tbon_12595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tbon_12600	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_12605	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_12610	COG0649	NAD binding
Tbon_12635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tbon_12650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tbon_12660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tbon_12665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tbon_12670	COG1381	Involved in DNA repair and RecF pathway recombination
Tbon_12680	COG0142	geranyltranstransferase activity
Tbon_12685	COG0084	hydrolase, TatD family'
Tbon_12690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tbon_12695	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tbon_12700	COG0516	GMP reductase activity
Tbon_12710	COG0561	phosphatase activity
Tbon_12715	COG2890	protein-(glutamine-N5) methyltransferase activity
Tbon_12720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tbon_12725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tbon_12735	COG1692	metallophosphoesterase
Tbon_12740	COG1418	mRNA catabolic process
Tbon_12745	COG2860	membrane
Tbon_12770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Tbon_12775	COG0596	Alpha beta hydrolase
Tbon_12780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Tbon_12790	COG0318	PFAM AMP-dependent synthetase and ligase
Tbon_12800	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tbon_12805	COG0750	zinc metalloprotease
Tbon_12825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tbon_12830	COG0439	Biotin carboxylase
Tbon_12835	COG5016	pyruvate
Tbon_12835	COG0511	ligase activity, forming carbon-carbon bonds
Tbon_12845	COG3584	3D domain protein
Tbon_12845	COG3583	domain protein
Tbon_12850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tbon_12855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tbon_12890	COG0114	fumarate hydratase activity
Tbon_12900	COG0537	adenosine 5'-monophosphoramidase activity
Tbon_12910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tbon_12930	COG0489	protein tyrosine kinase activity
Tbon_12940	COG0167	dihydroorotate dehydrogenase activity
Tbon_12950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tbon_12955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tbon_12960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tbon_12965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Tbon_12970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tbon_12980	COG0137	argininosuccinate synthase activity
Tbon_12990	COG0366	Alpha amylase catalytic
Tbon_13000	COG0495	leucyl-tRNA aminoacylation
Tbon_13025	COG0742	ribosomal rna small subunit methyltransferase
Tbon_13035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbon_13040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tbon_13045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tbon_13055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tbon_13070	COG0045	succinate-CoA ligase (ADP-forming) activity
Tbon_13075	COG0740	serine-type endopeptidase activity
Tbon_13095	COG0778	Nitroreductase
Tbon_13105	COG4552	Acetyltransferase involved in intracellular survival and related
Tbon_13120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tbon_13125	COG0070	glutamate synthase
Tbon_13125	COG0069	glutamate synthase activity
Tbon_13125	COG0067	glutamate synthase
Tbon_13145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tbon_13150	COG2205	protein histidine kinase activity
Tbon_13155	COG0745	RESPONSE REGULATOR receiver
Tbon_13160	COG1830	Aldolase
Tbon_13165	COG0745	RESPONSE REGULATOR receiver
Tbon_13170	COG1191	sigma factor activity
Tbon_13180	COG3409	Peptidoglycan-binding domain 1 protein
Tbon_13180	COG0793	Belongs to the peptidase S41A family
Tbon_13185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tbon_13195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tbon_13210	COG2217	Heavy metal translocating P-type atpase
Tbon_13215	COG2217	Heavy metal translocating P-type atpase
Tbon_13225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_13235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tbon_13245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tbon_13255	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tbon_13265	COG0358	DNA primase activity
Tbon_13280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_13285	COG0215	cysteine-tRNA ligase activity
Tbon_13310	COG1960	acyl-CoA dehydrogenase activity
Tbon_13315	COG1234	tRNA 3'-trailer cleavage
Tbon_13340	COG1136	(ABC) transporter
Tbon_13340	COG0577	efflux transmembrane transporter activity
Tbon_13345	COG0577	efflux transmembrane transporter activity
Tbon_13345	COG1136	(ABC) transporter
Tbon_13360	COG0018	arginyl-trna synthetase
Tbon_13380	COG1546	Belongs to the CinA family
Tbon_13380	COG1058	Belongs to the CinA family
Tbon_13390	COG0730	response to heat
Tbon_13420	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tbon_13445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_13455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_13475	COG0529	Catalyzes the synthesis of activated sulfate
Tbon_13475	COG2046	Belongs to the sulfate adenylyltransferase family
Tbon_13480	COG0175	sulfate reduction
Tbon_13485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tbon_13495	COG0113	porphobilinogen synthase activity
Tbon_13500	COG3383	formate dehydrogenase (NAD+) activity
Tbon_13505	COG3383	formate dehydrogenase (NAD+) activity
Tbon_13510	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tbon_13540	COG0788	formyltetrahydrofolate deformylase activity
Tbon_13545	COG4166	transmembrane transport
Tbon_13550	COG0601	transmembrane transport
Tbon_13555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tbon_13570	COG0785	Cytochrome C biogenesis protein
Tbon_13595	COG3226	Transcriptional regulator
Tbon_13605	COG0383	alpha-mannosidase activity
Tbon_13610	COG0728	peptidoglycan biosynthetic process
Tbon_13620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate