locus-tag	class	description
O0235_00015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O0235_00045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O0235_00050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O0235_00055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O0235_00070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O0235_00085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O0235_00095	COG1461	Dihydroxyacetone kinase
O0235_00100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O0235_00105	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O0235_00110	COG0564	pseudouridine synthase activity
O0235_00120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O0235_00135	COG1024	Enoyl-CoA hydratase
O0235_00145	COG0477	Major facilitator Superfamily
O0235_00160	COG0756	dUTP diphosphatase activity
O0235_00185	COG0596	Alpha beta hydrolase
O0235_00195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O0235_00200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O0235_00205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O0235_00220	COG3872	metal-dependent enzyme
O0235_00245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O0235_00275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O0235_00285	COG0308	aminopeptidase N
O0235_00300	COG0768	penicillin binding
O0235_00305	COG1960	acyl-CoA dehydrogenase activity
O0235_00325	COG1872	DUF167
O0235_00330	COG0423	glycine-tRNA ligase activity
O0235_00380	COG0745	RESPONSE REGULATOR receiver
O0235_00405	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_00415	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_00420	COG1968	undecaprenyl-diphosphatase activity
O0235_00445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0235_00450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0235_00455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
O0235_00475	COG1429	ligase activity, forming nitrogen-metal bonds
O0235_00480	COG1429	ligase activity, forming nitrogen-metal bonds
O0235_00515	COG2391	methyltransferase activity
O0235_00555	COG1960	acyl-CoA dehydrogenase activity
O0235_00565	COG1276	copper resistance
O0235_00565	COG2372	response to copper ion
O0235_00600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0235_00635	COG1331	Highly conserved protein containing a thioredoxin domain
O0235_00640	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
O0235_00645	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
O0235_00655	COG0483	inositol monophosphate 1-phosphatase activity
O0235_00675	COG0406	alpha-ribazole phosphatase activity
O0235_00695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O0235_00750	COG0596	Alpha beta hydrolase
O0235_00775	COG0673	inositol 2-dehydrogenase activity
O0235_00785	COG0604	alcohol dehydrogenase
O0235_00800	COG1960	acyl-CoA dehydrogenase activity
O0235_00805	COG1960	acyl-CoA dehydrogenase activity
O0235_00810	COG2030	dehydratase
O0235_00825	COG0741	lytic transglycosylase activity
O0235_00825	COG0739	heme binding
O0235_00825	COG1196	nuclear chromosome segregation
O0235_00835	COG1612	heme a metabolic process
O0235_00840	COG0109	protoheme IX farnesyltransferase activity
O0235_00845	COG0109	protoheme IX farnesyltransferase activity
O0235_00850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O0235_00855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O0235_00860	COG1845	cytochrome c oxidase, subunit III
O0235_00880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_00900	COG0436	Aminotransferase
O0235_00905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O0235_00910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O0235_00915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O0235_00920	COG0149	triose-phosphate isomerase activity
O0235_00925	COG0149	triose-phosphate isomerase activity
O0235_00930	COG0126	phosphoglycerate kinase activity
O0235_00935	COG0126	phosphoglycerate kinase activity
O0235_00940	COG0698	ribose 5-phosphate isomerase
O0235_00950	COG0519	Catalyzes the synthesis of GMP from XMP
O0235_00950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O0235_00960	COG0151	Belongs to the GarS family
O0235_00965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O0235_00970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O0235_00980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O0235_01020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O0235_01025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O0235_01035	COG1160	GTP binding
O0235_01045	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O0235_01050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O0235_01085	COG2814	Major facilitator Superfamily
O0235_01090	COG0708	Exodeoxyribonuclease III
O0235_01125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O0235_01135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O0235_01140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0235_01145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0235_01155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0235_01170	COG0195	Participates in both transcription termination and antitermination
O0235_01175	COG2740	Nucleic-acid-binding protein implicated in transcription termination
O0235_01180	COG3064	Membrane
O0235_01180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O0235_01200	COG0483	inositol monophosphate 1-phosphatase activity
O0235_01210	COG0667	Aldo Keto reductase
O0235_01220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O0235_01225	COG2226	methyltransferase
O0235_01230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O0235_01235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0235_01240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0235_01245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0235_01250	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0235_01250	COG0022	dehydrogenase e1 component
O0235_01255	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0235_01280	COG0746	molybdenum cofactor guanylyltransferase activity
O0235_01320	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_01330	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
O0235_01335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
O0235_01340	COG3118	belongs to the thioredoxin family
O0235_01345	COG0492	ferredoxin-NADP+ reductase activity
O0235_01345	COG3118	belongs to the thioredoxin family
O0235_01365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_01380	COG1131	(ABC) transporter
O0235_01420	COG4604	ABC transporter, ATP-binding protein
O0235_01425	COG1121	(ABC) transporter
O0235_01465	COG0830	nickel cation binding
O0235_01475	COG0832	Belongs to the urease beta subunit family
O0235_01480	COG0831	urea catabolic process
O0235_01535	COG0584	glycerophosphoryl diester phosphodiesterase
O0235_01565	COG1120	ATPase activity
O0235_01575	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
O0235_01590	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
O0235_01600	COG1492	cobalamin metabolic process
O0235_01630	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
O0235_01685	COG0343	queuine tRNA-ribosyltransferase activity
O0235_01695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O0235_01700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O0235_01710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O0235_01725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O0235_01730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O0235_01735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O0235_01750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O0235_01760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O0235_01770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O0235_01785	COG0758	DNA mediated transformation
O0235_01785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O0235_01790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O0235_01805	COG4974	Belongs to the 'phage' integrase family
O0235_01815	COG0006	proline dipeptidase activity
O0235_01830	COG1722	exodeoxyribonuclease VII activity
O0235_01850	COG0165	Argininosuccinate lyase
O0235_01860	COG1011	Hydrolase
O0235_01895	COG0297	glycogen (starch) synthase activity
O0235_01900	COG0297	glycogen (starch) synthase activity
O0235_01915	COG3956	TIGRFAM MazG family protein
O0235_01955	COG3243	poly(R)-hydroxyalkanoic acid synthase
O0235_01970	COG1562	ergosterol biosynthetic process
O0235_02050	COG1321	iron dependent repressor
O0235_02105	COG0237	dephospho-CoA kinase activity
O0235_02125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O0235_02140	COG0494	nUDIX hydrolase
O0235_02155	COG1053	succinate dehydrogenase
O0235_02160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O0235_02200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O0235_02215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O0235_02220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O0235_02225	COG0762	integral membrane protein
O0235_02235	COG1131	(ABC) transporter
O0235_02245	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O0235_02250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O0235_02255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O0235_02260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O0235_02270	COG1957	nucleoside hydrolase
O0235_02290	COG0039	L-malate dehydrogenase activity
O0235_02300	COG2814	Major facilitator Superfamily
O0235_02310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O0235_02330	COG2267	carboxylic ester hydrolase activity
O0235_02350	COG0411	ABC transporter
O0235_02375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O0235_02385	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_02405	COG1139	Iron-sulfur cluster binding protein
O0235_02415	COG0247	lactate metabolic process
O0235_02435	COG2030	dehydratase
O0235_02440	COG1611	Belongs to the LOG family
O0235_02460	COG2062	phosphohistidine phosphatase, SixA
O0235_02465	COG0248	Ppx GppA phosphatase
O0235_02480	COG1960	acyl-CoA dehydrogenase activity
O0235_02490	COG1960	acyl-CoA dehydrogenase activity
O0235_02500	COG4974	Belongs to the 'phage' integrase family
O0235_02505	COG4974	Belongs to the 'phage' integrase family
O0235_02520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0235_02530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O0235_02530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O0235_02535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O0235_02550	COG0822	iron-sulfur transferase activity
O0235_02560	COG0312	modulator of DNA gyrase
O0235_02600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O0235_02600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O0235_02605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O0235_02615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O0235_02635	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O0235_02650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0235_02655	COG0601	transmembrane transport
O0235_02670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O0235_02705	COG1846	Transcriptional regulator
O0235_02750	COG0393	Putative heavy-metal-binding
O0235_02805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O0235_02810	COG1837	Belongs to the UPF0109 family
O0235_02825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O0235_02845	COG3842	ATPase activity
O0235_02855	COG3833	ABC-type maltose transport systems, permease component
O0235_02860	COG1175	transmembrane transport
O0235_02900	COG0469	pyruvate kinase activity
O0235_02905	COG0604	alcohol dehydrogenase
O0235_02910	COG0604	alcohol dehydrogenase
O0235_02940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O0235_02945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O0235_02960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O0235_02965	COG0107	imidazoleglycerol-phosphate synthase activity
O0235_02970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O0235_02975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O0235_02990	COG1792	Involved in formation and maintenance of cell shape
O0235_03000	COG0768	penicillin binding
O0235_03005	COG0772	Belongs to the SEDS family
O0235_03020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O0235_03025	COG1307	EDD domain protein, DegV family
O0235_03030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O0235_03055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O0235_03100	COG2154	pterin-4-alpha-carbinolamine dehydratase
O0235_03105	COG2878	Part of a membrane complex involved in electron transport
O0235_03120	COG0596	Alpha beta hydrolase
O0235_03140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_03155	COG1388	LysM domain
O0235_03155	COG1705	Flagellar rod assembly protein muramidase FlgJ
O0235_03160	COG2234	aminopeptidase activity
O0235_03180	COG0322	excinuclease ABC activity
O0235_03215	COG0083	homoserine kinase activity
O0235_03245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O0235_03245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O0235_03250	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0235_03250	COG0596	Alpha beta hydrolase
O0235_03295	COG1121	(ABC) transporter
O0235_03300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O0235_03320	COG1074	ATP-dependent DNA helicase activity
O0235_03370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_03390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_03400	COG0714	Associated with various cellular activities
O0235_03410	COG2304	oxidoreductase activity
O0235_03415	COG2267	carboxylic ester hydrolase activity
O0235_03435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O0235_03455	COG0202	RNA polymerase activity
O0235_03460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O0235_03465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O0235_03475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O0235_03480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O0235_03485	COG0024	Methionine aminopeptidase
O0235_03490	COG0563	adenylate kinase activity
O0235_03495	COG0201	protein transport
O0235_03500	COG0200	Binds to the 23S rRNA
O0235_03505	COG1841	ribosomal large subunit assembly
O0235_03510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O0235_03515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O0235_03520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O0235_03525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O0235_03535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O0235_03540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O0235_03545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O0235_03555	COG0255	Belongs to the universal ribosomal protein uL29 family
O0235_03560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O0235_03570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O0235_03575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O0235_03580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O0235_03585	COG0089	rRNA binding
O0235_03590	COG0088	Forms part of the polypeptide exit tunnel
O0235_03595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O0235_03600	COG0051	transcription antitermination factor activity, RNA binding
O0235_03610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O0235_03615	COG0049	tRNA binding
O0235_03620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O0235_03640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O0235_03645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O0235_03650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O0235_03655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O0235_03690	COG1024	Enoyl-CoA hydratase
O0235_03720	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
O0235_03730	COG1677	Flagellar hook-basal body complex protein FliE
O0235_03750	COG1157	protein secretion by the type III secretion system
O0235_03760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O0235_03765	COG1766	The M ring may be actively involved in energy transduction
O0235_03795	COG3959	Transketolase, thiamine diphosphate binding domain
O0235_03805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O0235_03810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O0235_03815	COG1733	regulation of RNA biosynthetic process
O0235_03825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_03845	COG3345	alpha-galactosidase
O0235_03850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O0235_03855	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O0235_03880	COG2203	Gaf domain
O0235_03880	COG3706	GGDEF domain
O0235_03880	COG5001	Diguanylate cyclase
O0235_03880	COG4251	negative regulation of phosphorylation
O0235_03885	COG0302	gtp cyclohydrolase
O0235_03900	COG2199	diguanylate cyclase activity
O0235_03900	COG2200	EAL domain
O0235_03900	COG3287	FIST C domain
O0235_03910	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_03920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0235_03925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O0235_03945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O0235_03945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O0235_03950	COG1666	GTP binding
O0235_03970	COG2304	oxidoreductase activity
O0235_03990	COG0714	Associated with various cellular activities
O0235_03995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O0235_04000	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O0235_04005	COG0314	molybdopterin synthase activity
O0235_04010	COG0494	nUDIX hydrolase
O0235_04020	COG1484	DNA-dependent DNA replication
O0235_04030	COG0305	Participates in initiation and elongation during chromosome replication
O0235_04035	COG0359	binds to the 23S rRNA
O0235_04090	COG0531	amino acid
O0235_04120	COG1030	water channel activity
O0235_04135	COG1045	serine acetyltransferase
O0235_04155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O0235_04180	COG5002	protein histidine kinase activity
O0235_04185	COG0745	RESPONSE REGULATOR receiver
O0235_04190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O0235_04195	COG0573	inorganic phosphate transmembrane transporter activity
O0235_04200	COG0573	inorganic phosphate transmembrane transporter activity
O0235_04205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O0235_04210	COG0704	Plays a role in the regulation of phosphate uptake
O0235_04235	COG2239	Acts as a magnesium transporter
O0235_04240	COG0415	Belongs to the DNA photolyase family
O0235_04245	COG0427	acetyl-CoA hydrolase
O0235_04275	COG1024	Enoyl-CoA hydratase
O0235_04280	COG0427	acetyl-CoA hydrolase
O0235_04290	COG2226	methyltransferase
O0235_04295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O0235_04295	COG1796	DNA polymerase
O0235_04305	COG0392	lysyltransferase activity
O0235_04305	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O0235_04315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O0235_04325	COG0181	hydroxymethylbilane synthase activity
O0235_04330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O0235_04340	COG1648	precorrin-2 dehydrogenase activity
O0235_04340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O0235_04350	COG3253	May function as heme-dependent peroxidase
O0235_04355	COG0667	Aldo Keto reductase
O0235_04365	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O0235_04390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_04420	COG3706	GGDEF domain
O0235_04425	COG1960	acyl-CoA dehydrogenase activity
O0235_04450	COG1185	polyribonucleotide nucleotidyltransferase activity
O0235_04460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O0235_04465	COG1185	polyribonucleotide nucleotidyltransferase activity
O0235_04505	COG1012	belongs to the aldehyde dehydrogenase family
O0235_04515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O0235_04530	COG1024	Enoyl-CoA hydratase
O0235_04555	COG2814	Major facilitator Superfamily
O0235_04560	COG0473	3-isopropylmalate dehydrogenase activity
O0235_04570	COG2318	DinB family
O0235_04595	COG0778	Nitroreductase
O0235_04605	COG1254	Belongs to the acylphosphatase family
O0235_04615	COG0459	protein refolding
O0235_04620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O0235_04625	COG0315	cyclic pyranopterin monophosphate synthase activity
O0235_04635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O0235_04640	COG0222	ribosome binding
O0235_04645	COG4651	solute:proton antiporter activity
O0235_04645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O0235_04650	COG1063	alcohol dehydrogenase
O0235_04655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O0235_04665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O0235_04675	COG2204	response regulator
O0235_04680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O0235_04695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O0235_04715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O0235_04750	COG0616	signal peptide processing
O0235_04780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O0235_04785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O0235_04790	COG0318	PFAM AMP-dependent synthetase and ligase
O0235_04795	COG1024	Enoyl-CoA hydratase
O0235_04810	COG2197	response regulator
O0235_04835	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
O0235_04840	COG0473	3-isopropylmalate dehydrogenase activity
O0235_04860	COG0792	nuclease activity
O0235_04865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O0235_04870	COG1196	nuclear chromosome segregation
O0235_04870	COG0739	heme binding
O0235_04870	COG0741	lytic transglycosylase activity
O0235_04900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O0235_04925	COG2267	carboxylic ester hydrolase activity
O0235_04960	COG0484	heat shock protein binding
O0235_04965	COG2264	protein methyltransferase activity
O0235_04980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O0235_04985	COG0174	glutamine synthetase
O0235_05005	COG0492	ferredoxin-NADP+ reductase activity
O0235_05010	COG3118	belongs to the thioredoxin family
O0235_05015	COG1937	Protein conserved in bacteria
O0235_05020	COG1929	Belongs to the glycerate kinase type-1 family
O0235_05070	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O0235_05090	COG0427	acetyl-CoA hydrolase
O0235_05095	COG3852	Histidine kinase
O0235_05100	COG1960	acyl-CoA dehydrogenase activity
O0235_05120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O0235_05130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0235_05140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O0235_05155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0235_05160	COG1410	methionine synthase
O0235_05160	COG0646	methionine synthase
O0235_05195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O0235_05200	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O0235_05205	COG1528	Iron-storage protein
O0235_05240	COG1959	2 iron, 2 sulfur cluster binding
O0235_05245	COG0484	heat shock protein binding
O0235_05265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O0235_05275	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
O0235_05280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O0235_05290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0235_05295	COG0745	RESPONSE REGULATOR receiver
O0235_05300	COG5002	protein histidine kinase activity
O0235_05325	COG0459	protein refolding
O0235_05330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O0235_05360	COG0783	Belongs to the Dps family
O0235_05400	COG2124	cytochrome p450
O0235_05405	COG0135	phosphoribosylanthranilate isomerase activity
O0235_05410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O0235_05415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O0235_05420	COG0602	queuosine metabolic process
O0235_05450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0235_05465	COG1132	(ABC) transporter
O0235_05470	COG1132	(ABC) transporter
O0235_05475	COG1333	cytochrome c biogenesis protein
O0235_05480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0235_05490	COG1111	helicase
O0235_05490	COG1205	dead DEAH box helicase
O0235_05500	COG0138	bifunctional purine biosynthesis protein purh
O0235_05510	COG0494	nUDIX hydrolase
O0235_05530	COG1309	transcriptional regulator
O0235_05535	COG0183	Belongs to the thiolase family
O0235_05545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0235_05550	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O0235_05555	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O0235_05565	COG0747	negative chemotaxis
O0235_05580	COG2378	regulation of single-species biofilm formation
O0235_05605	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_05610	COG0483	inositol monophosphate 1-phosphatase activity
O0235_05620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O0235_05625	COG1420	regulation of RNA biosynthetic process
O0235_05645	COG0071	Belongs to the small heat shock protein (HSP20) family
O0235_05685	COG0300	oxidoreductase activity
O0235_05690	COG0588	phosphoglycerate mutase activity
O0235_05695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O0235_05700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0235_05725	COG0268	Binds directly to 16S ribosomal RNA
O0235_05730	COG0300	oxidoreductase activity
O0235_05740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O0235_05750	COG0739	heme binding
O0235_05755	COG2267	carboxylic ester hydrolase activity
O0235_05770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0235_05780	COG1271	oxidase subunit
O0235_05805	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_05805	COG3321	synthase
O0235_05805	COG0604	alcohol dehydrogenase
O0235_05815	COG2272	Belongs to the type-B carboxylesterase lipase family
O0235_05825	COG0174	glutamine synthetase
O0235_05830	COG0612	Peptidase, M16
O0235_05875	COG0504	CTP synthase activity
O0235_05885	COG2897	thiosulfate sulfurtransferase activity
O0235_05890	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_05895	COG0427	acetyl-CoA hydrolase
O0235_05930	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_05940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O0235_05950	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0235_05955	COG3199	ATP-NAD kinase
O0235_05960	COG0022	dehydrogenase e1 component
O0235_05965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0235_05975	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_05980	COG0574	Belongs to the PEP-utilizing enzyme family
O0235_05980	COG3848	Pyruvate phosphate dikinase
O0235_05995	COG1960	acyl-CoA dehydrogenase activity
O0235_06000	COG1960	acyl-CoA dehydrogenase activity
O0235_06025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0235_06030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O0235_06030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O0235_06035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0235_06040	COG2318	DinB family
O0235_06050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O0235_06060	COG0477	Major facilitator Superfamily
O0235_06070	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
O0235_06085	COG1845	cytochrome c oxidase, subunit III
O0235_06130	COG0653	protein targeting
O0235_06140	COG1007	ATP synthesis coupled electron transport
O0235_06145	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O0235_06150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O0235_06155	COG0713	ATP synthesis coupled electron transport
O0235_06170	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O0235_06175	COG0649	NAD binding
O0235_06180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O0235_06185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O0235_06190	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O0235_06195	COG2226	methyltransferase
O0235_06200	COG1575	Belongs to the MenA family. Type 1 subfamily
O0235_06215	COG0667	Aldo Keto reductase
O0235_06285	COG1797	cobyrinic acid a,c-diamide synthase activity
O0235_06325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O0235_06330	COG0724	RNA recognition motif
O0235_06340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O0235_06345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O0235_06350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
O0235_06360	COG0215	cysteine-tRNA ligase activity
O0235_06430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O0235_06445	COG0338	D12 class N6 adenine-specific DNA methyltransferase
O0235_06450	COG2124	cytochrome p450
O0235_06465	COG1024	Enoyl-CoA hydratase
O0235_06510	COG2119	membrane
O0235_06545	COG0488	(ABC) transporter
O0235_06555	COG1803	Methylglyoxal synthase
O0235_06555	COG1597	lipid kinase activity
O0235_06560	COG0277	FAD linked oxidase domain protein
O0235_06600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O0235_06615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O0235_06625	COG2217	Heavy metal translocating P-type atpase
O0235_06635	COG1283	sodium-dependent phosphate transmembrane transporter activity
O0235_06655	COG0632	four-way junction helicase activity
O0235_06660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O0235_06685	COG1024	Enoyl-CoA hydratase
O0235_06705	COG3842	ATPase activity
O0235_06710	COG1178	ABC-type Fe3 transport system permease component
O0235_06720	COG0592	DNA-directed DNA polymerase activity
O0235_06735	COG0038	chloride channel
O0235_06760	COG1742	UPF0060 membrane protein
O0235_06780	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O0235_06800	COG1309	transcriptional regulator
O0235_06805	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_06810	COG2409	Drug exporters of the RND superfamily
O0235_06815	COG2409	Drug exporters of the RND superfamily
O0235_06820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O0235_06840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0235_06845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O0235_06930	COG1575	Belongs to the MenA family. Type 1 subfamily
O0235_06935	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O0235_06950	COG0556	nucleotide-excision repair
O0235_06955	COG1024	Enoyl-CoA hydratase
O0235_06970	COG1024	Enoyl-CoA hydratase
O0235_06985	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O0235_06990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O0235_07000	COG0574	Belongs to the PEP-utilizing enzyme family
O0235_07000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O0235_07010	COG1131	(ABC) transporter
O0235_07040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O0235_07080	COG2201	protein-glutamate methylesterase activity
O0235_07095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O0235_07105	COG0741	lytic transglycosylase activity
O0235_07120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O0235_07125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O0235_07130	COG0706	membrane insertase activity
O0235_07135	COG1847	R3H domain protein
O0235_07135	COG1847	R3H domain protein
O0235_07145	COG1192	Involved in chromosome partitioning
O0235_07150	COG1475	DNA binding
O0235_07165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O0235_07175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O0235_07175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O0235_07190	COG1960	acyl-CoA dehydrogenase activity
O0235_07205	COG2261	transglycosylase associated protein
O0235_07225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0235_07255	COG3845	ABC transporter
O0235_07270	COG1595	DNA-templated transcription, initiation
O0235_07275	COG1215	transferase activity, transferring glycosyl groups
O0235_07300	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O0235_07305	COG1920	GTP binding
O0235_07335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O0235_07345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O0235_07345	COG4651	solute:proton antiporter activity
O0235_07350	COG0596	Alpha beta hydrolase
O0235_07365	COG0281	malic enzyme
O0235_07380	COG1832	CoA-binding protein
O0235_07385	COG0183	Belongs to the thiolase family
O0235_07395	COG2003	Belongs to the UPF0758 family
O0235_07420	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O0235_07430	COG0758	DNA mediated transformation
O0235_07445	COG0745	RESPONSE REGULATOR receiver
O0235_07470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O0235_07475	COG3854	ATPases associated with a variety of cellular activities
O0235_07485	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
O0235_07490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O0235_07530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O0235_07535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O0235_07540	COG1250	3-hydroxyacyl-CoA dehydrogenase
O0235_07600	COG1231	oxidoreductase activity
O0235_07610	COG0347	Belongs to the P(II) protein family
O0235_07615	COG0004	ammonium transporteR
O0235_07620	COG2086	electron transfer activity
O0235_07625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O0235_07630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O0235_07630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O0235_07635	COG1703	isobutyryl-CoA mutase activity
O0235_07645	COG0438	transferase activity, transferring glycosyl groups
O0235_07655	COG0659	secondary active sulfate transmembrane transporter activity
O0235_07665	COG3706	GGDEF domain
O0235_07710	COG1053	succinate dehydrogenase
O0235_07715	COG0701	Predicted permease
O0235_07725	COG0823	Involved in the tonB-independent uptake of proteins
O0235_07750	COG1196	nuclear chromosome segregation
O0235_07750	COG0741	lytic transglycosylase activity
O0235_07750	COG0739	heme binding
O0235_07760	COG0717	Belongs to the dCTP deaminase family
O0235_07770	COG0438	transferase activity, transferring glycosyl groups
O0235_07775	COG1011	Hydrolase
O0235_07800	COG2226	methyltransferase
O0235_07825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O0235_07830	COG3191	aminopeptidase activity
O0235_07850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
O0235_07860	COG1960	acyl-CoA dehydrogenase activity
O0235_07875	COG1194	a g-specific adenine glycosylase
O0235_07915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O0235_07920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O0235_07945	COG0514	ATP-dependent DNA helicase (RecQ)
O0235_07950	COG0514	ATP-dependent DNA helicase (RecQ)
O0235_07975	COG1215	transferase activity, transferring glycosyl groups
O0235_08010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
O0235_08015	COG1610	YqeY-like protein
O0235_08025	COG1480	7TM receptor with intracellular HD hydrolase
O0235_08030	COG0047	phosphoribosylformylglycinamidine synthase activity
O0235_08040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O0235_08055	COG0768	penicillin binding
O0235_08060	COG1024	Enoyl-CoA hydratase
O0235_08065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0235_08080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O0235_08080	COG1213	nucleotidyl transferase
O0235_08130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0235_08135	COG2181	nitrate reductase activity
O0235_08135	COG0247	lactate metabolic process
O0235_08140	COG0318	PFAM AMP-dependent synthetase and ligase
O0235_08145	COG1793	dna ligase
O0235_08215	COG2267	carboxylic ester hydrolase activity
O0235_08220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O0235_08235	COG0527	aspartate kinase activity
O0235_08260	COG2814	Major facilitator Superfamily
O0235_08270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O0235_08280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O0235_08285	COG0724	RNA recognition motif
O0235_08320	COG1733	regulation of RNA biosynthetic process
O0235_08325	COG1388	LysM domain
O0235_08325	COG3942	CHAP domain
O0235_08355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O0235_08390	COG1024	Enoyl-CoA hydratase
O0235_08420	COG2353	YceI-like domain
O0235_08425	COG1024	Enoyl-CoA hydratase
O0235_08450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O0235_08455	COG0360	Binds together with S18 to 16S ribosomal RNA
O0235_08475	COG0460	homoserine dehydrogenase
O0235_08485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O0235_08490	COG2326	polyphosphate kinase activity
O0235_08510	COG4585	Histidine kinase
O0235_08525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O0235_08540	COG0187	DNA topoisomerase II activity
O0235_08560	COG0598	Magnesium transport protein CorA
O0235_08570	COG1595	DNA-templated transcription, initiation
O0235_08585	COG1024	Enoyl-CoA hydratase
O0235_08600	COG1024	Enoyl-CoA hydratase
O0235_08600	COG1250	3-hydroxyacyl-CoA dehydrogenase
O0235_08615	COG1234	tRNA 3'-trailer cleavage
O0235_08650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O0235_08655	COG2223	nitrite transmembrane transporter activity
O0235_08670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O0235_08700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O0235_08705	COG3852	Histidine kinase
O0235_08710	COG0739	heme binding
O0235_08710	COG0741	lytic transglycosylase activity
O0235_08710	COG1196	nuclear chromosome segregation
O0235_08735	COG2239	Acts as a magnesium transporter
O0235_08740	COG2226	methyltransferase
O0235_08770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O0235_08785	COG0482	sulfurtransferase activity
O0235_08790	COG0799	negative regulation of ribosome biogenesis
O0235_08795	COG1024	Enoyl-CoA hydratase
O0235_08805	COG1132	(ABC) transporter
O0235_08810	COG1132	(ABC) transporter
O0235_08820	COG2200	EAL domain
O0235_08820	COG2199	diguanylate cyclase activity
O0235_08820	COG2202	Pas domain
O0235_08825	COG1253	flavin adenine dinucleotide binding
O0235_08850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O0235_08870	COG1024	Enoyl-CoA hydratase
O0235_08880	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_08900	COG0588	phosphoglycerate mutase activity
O0235_08910	COG1024	Enoyl-CoA hydratase
O0235_08915	COG0681	Belongs to the peptidase S26 family
O0235_08925	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0235_08925	COG0596	Alpha beta hydrolase
O0235_08930	COG1960	acyl-CoA dehydrogenase activity
O0235_08935	COG0840	transmembrane signaling receptor activity
O0235_08970	COG1950	PFAM Membrane protein of
O0235_08985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O0235_09000	COG0542	response to heat
O0235_09005	COG0789	Transcriptional regulator
O0235_09010	COG0484	heat shock protein binding
O0235_09015	COG0071	Belongs to the small heat shock protein (HSP20) family
O0235_09025	COG2835	tetraacyldisaccharide 4'-kinase activity
O0235_09055	COG0601	transmembrane transport
O0235_09060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0235_09075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0235_09085	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
O0235_09110	COG0525	valine-tRNA ligase activity
O0235_09135	COG0513	Belongs to the DEAD box helicase family
O0235_09145	COG3608	succinylglutamate desuccinylase aspartoacylase
O0235_09145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
O0235_09155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O0235_09155	COG0189	ligase activity
O0235_09180	COG5001	Diguanylate cyclase
O0235_09180	COG1716	ATPase activity
O0235_09210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O0235_09255	COG0612	Peptidase, M16
O0235_09265	COG4552	Acetyltransferase involved in intracellular survival and related
O0235_09330	COG1987	bacterial-type flagellum assembly
O0235_09335	COG1684	flagellar biosynthetic protein fliR
O0235_09350	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O0235_09355	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O0235_09360	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O0235_09370	COG1191	sigma factor activity
O0235_09390	COG4786	Flagellar basal body rod
O0235_09420	COG1256	bacterial-type flagellum assembly
O0235_09420	COG4786	Flagellar basal body rod
O0235_09430	COG1024	Enoyl-CoA hydratase
O0235_09435	COG1024	Enoyl-CoA hydratase
O0235_09470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0235_09510	COG1494	fructose-1,6-bisphosphatase
O0235_09535	COG1104	cysteine desulfurase activity
O0235_09545	COG0657	acetylesterase activity
O0235_09560	COG0357	Ribosomal RNA small subunit methyltransferase G
O0235_09565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O0235_09585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O0235_09600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0235_09605	COG1595	DNA-templated transcription, initiation
O0235_09615	COG2442	InterPro IPR007367
O0235_09625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O0235_09655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O0235_09675	COG2072	flavoprotein involved in K transport
O0235_09680	COG0183	Belongs to the thiolase family
O0235_09685	COG1597	lipid kinase activity
O0235_09715	COG2226	methyltransferase
O0235_09720	COG1024	Enoyl-CoA hydratase
O0235_09725	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_09745	COG1320	monovalent cation:proton antiporter activity
O0235_09750	COG2212	antiporter activity
O0235_09755	COG1863	multisubunit Na H antiporter MnhE subunit
O0235_09760	COG0651	ATP synthesis coupled electron transport
O0235_09765	COG1006	Multisubunit Na H antiporter MnhC subunit
O0235_09770	COG2111	Na H antiporter
O0235_09775	COG2111	Na H antiporter
O0235_09775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O0235_09785	COG0686	Belongs to the AlaDH PNT family
O0235_09790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0235_09790	COG5549	protein import
O0235_09815	COG0247	lactate metabolic process
O0235_09820	COG0277	FAD linked oxidase domain protein
O0235_09825	COG0277	FAD linked oxidase domain protein
O0235_09850	COG4106	trans-aconitate 2-methyltransferase activity
O0235_09860	COG1024	Enoyl-CoA hydratase
O0235_09865	COG1116	anion transmembrane transporter activity
O0235_09870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O0235_09875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O0235_09890	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_09895	COG0367	asparagine synthase
O0235_09920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O0235_09925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0235_09950	COG0438	transferase activity, transferring glycosyl groups
O0235_09960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O0235_09975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_10030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O0235_10035	COG0681	Belongs to the peptidase S26 family
O0235_10050	COG2968	Membrane
O0235_10065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O0235_10090	COG1122	ATPase activity
O0235_10100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O0235_10110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O0235_10115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O0235_10120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O0235_10125	COG1862	Preprotein translocase
O0235_10130	COG0617	tRNA 3'-terminal CCA addition
O0235_10140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_10150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0235_10155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
O0235_10160	COG0717	Belongs to the dCTP deaminase family
O0235_10165	COG0248	Ppx GppA phosphatase
O0235_10170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O0235_10175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O0235_10195	COG1063	alcohol dehydrogenase
O0235_10200	COG0473	3-isopropylmalate dehydrogenase activity
O0235_10220	COG0066	3-isopropylmalate dehydratase activity
O0235_10225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O0235_10295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0235_10315	COG2132	Multicopper oxidase
O0235_10325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O0235_10330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O0235_10345	COG2030	dehydratase
O0235_10370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0235_10375	COG0601	transmembrane transport
O0235_10380	COG0747	negative chemotaxis
O0235_10405	COG0012	GTP binding
O0235_10420	COG0778	Nitroreductase
O0235_10450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_10460	COG0546	phosphoglycolate phosphatase activity
O0235_10465	COG0673	inositol 2-dehydrogenase activity
O0235_10490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O0235_10520	COG0456	acetyltransferase
O0235_10555	COG1960	acyl-CoA dehydrogenase activity
O0235_10565	COG2409	Drug exporters of the RND superfamily
O0235_10585	COG0714	Associated with various cellular activities
O0235_10615	COG1305	Transglutaminase-like
O0235_10635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0235_10640	COG0601	transmembrane transport
O0235_10670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O0235_10685	COG0366	Alpha amylase catalytic
O0235_10705	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_10720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O0235_10725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O0235_10795	COG0105	UTP biosynthetic process
O0235_10800	COG0105	UTP biosynthetic process
O0235_10810	COG0802	atpase or kinase
O0235_10830	COG0372	Belongs to the citrate synthase family
O0235_10835	COG0372	Belongs to the citrate synthase family
O0235_10840	COG0372	Belongs to the citrate synthase family
O0235_10845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O0235_10845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O0235_10850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O0235_10850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O0235_10855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O0235_10855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O0235_10865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O0235_10885	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
O0235_10890	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
O0235_10900	COG0180	Tryptophanyl-tRNA synthetase
O0235_10920	COG0546	phosphoglycolate phosphatase activity
O0235_10930	COG0512	Glutamine amidotransferase of anthranilate synthase
O0235_10935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O0235_10940	COG0134	indole-3-glycerol-phosphate synthase activity
O0235_10945	COG0135	phosphoribosylanthranilate isomerase activity
O0235_10950	COG0133	tryptophan synthase activity
O0235_10965	COG0159	tryptophan synthase activity
O0235_10975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
O0235_10985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O0235_10990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O0235_10995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O0235_11000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O0235_11005	COG0028	Belongs to the TPP enzyme family
O0235_11010	COG0440	acetolactate synthase activity
O0235_11020	COG0628	permease
O0235_11075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O0235_11100	COG1187	pseudouridine synthase activity
O0235_11115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_11120	COG1678	Uncharacterized ACR, COG1678
O0235_11130	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
O0235_11135	COG0501	Belongs to the peptidase M48B family
O0235_11140	COG0412	Dienelactone hydrolase
O0235_11155	COG0386	Belongs to the glutathione peroxidase family
O0235_11160	COG2723	6-phospho-beta-galactosidase activity
O0235_11175	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_11185	COG2084	Dehydrogenase
O0235_11195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O0235_11225	COG0193	aminoacyl-tRNA hydrolase activity
O0235_11255	COG0542	response to heat
O0235_11260	COG0085	RNA polymerase activity
O0235_11265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O0235_11275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O0235_11280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O0235_11285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O0235_11290	COG1086	Polysaccharide biosynthesis protein
O0235_11305	COG0673	inositol 2-dehydrogenase activity
O0235_11315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O0235_11320	COG1960	acyl-CoA dehydrogenase activity
O0235_11345	COG0438	transferase activity, transferring glycosyl groups
O0235_11350	COG0613	PHP domain protein
O0235_11365	COG1024	Enoyl-CoA hydratase
O0235_11380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0235_11400	COG0493	'glutamate synthase
O0235_11400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
O0235_11410	COG0039	L-malate dehydrogenase activity
O0235_11430	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
O0235_11475	COG1484	DNA-dependent DNA replication
O0235_11505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
O0235_11510	COG0732	type I restriction modification DNA specificity domain
O0235_11520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
O0235_11545	COG0517	IMP dehydrogenase activity
O0235_11545	COG0617	tRNA 3'-terminal CCA addition
O0235_11545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O0235_11550	COG1024	Enoyl-CoA hydratase
O0235_11570	COG1024	Enoyl-CoA hydratase
O0235_11575	COG2151	metal-sulfur cluster biosynthetic enzyme
O0235_11580	COG0822	iron-sulfur transferase activity
O0235_11585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O0235_11595	COG0719	Fe-S assembly protein
O0235_11600	COG0719	Fe-S assembly protein
O0235_11605	COG0396	ATPase activity
O0235_11630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O0235_11640	COG0577	efflux transmembrane transporter activity
O0235_11655	COG0336	Belongs to the RNA methyltransferase TrmD family
O0235_11660	COG0521	Mo-molybdopterin cofactor biosynthetic process
O0235_11665	COG2001	Belongs to the MraZ family
O0235_11670	COG0275	rRNA processing
O0235_11680	COG0768	penicillin binding
O0235_11685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O0235_11690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O0235_11695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O0235_11700	COG0772	Belongs to the SEDS family
O0235_11705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O0235_11710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O0235_11715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O0235_11720	COG1181	Belongs to the D-alanine--D-alanine ligase family
O0235_11725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O0235_11735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O0235_11755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O0235_11765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O0235_11770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O0235_11785	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O0235_11795	COG0730	response to heat
O0235_11800	COG0825	malonyl-CoA metabolic process
O0235_11800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O0235_11805	COG1674	ftsk spoiiie
O0235_11810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O0235_11815	COG1573	uracil-dna glycosylase
O0235_11825	COG0805	protein transport
O0235_11830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O0235_11835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0235_11845	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_11850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O0235_11875	COG1960	acyl-CoA dehydrogenase activity
O0235_11880	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_11890	COG4770	biotin carboxylase activity
O0235_11920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O0235_11925	COG0196	riboflavin kinase activity
O0235_11930	COG2050	protein possibly involved in aromatic compounds catabolism
O0235_11950	COG0577	efflux transmembrane transporter activity
O0235_11950	COG1136	(ABC) transporter
O0235_11955	COG4591	ABC-type transport system involved in lipoprotein release permease component
O0235_11955	COG1136	(ABC) transporter
O0235_12005	COG1024	Enoyl-CoA hydratase
O0235_12010	COG1194	a g-specific adenine glycosylase
O0235_12015	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
O0235_12025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O0235_12030	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
O0235_12035	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
O0235_12040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O0235_12070	COG0339	signal peptide processing
O0235_12075	COG0028	Belongs to the TPP enzyme family
O0235_12080	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
O0235_12085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O0235_12090	COG0497	DNA recombination
O0235_12110	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_12120	COG0644	oxidoreductase
O0235_12125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O0235_12130	COG2814	Major facilitator Superfamily
O0235_12170	COG0081	regulation of translation
O0235_12175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O0235_12185	COG0601	transmembrane transport
O0235_12190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0235_12195	COG0250	Participates in transcription elongation, termination and antitermination
O0235_12205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O0235_12210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O0235_12245	COG0217	transcriptional regulatory protein
O0235_12250	COG0321	lipoyl(octanoyl) transferase activity
O0235_12265	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
O0235_12280	COG2226	methyltransferase
O0235_12285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_12290	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_12300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O0235_12325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O0235_12330	COG0424	maF-like protein
O0235_12335	COG2197	response regulator
O0235_12360	COG0436	Aminotransferase
O0235_12365	COG4797	methyltransferase
O0235_12365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O0235_12370	COG0154	amidase activity
O0235_12385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O0235_12390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O0235_12395	COG2897	thiosulfate sulfurtransferase activity
O0235_12415	COG0166	Belongs to the GPI family
O0235_12425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0235_12430	COG0667	Aldo Keto reductase
O0235_12445	COG1846	Transcriptional regulator
O0235_12520	COG1215	transferase activity, transferring glycosyl groups
O0235_12525	COG1960	acyl-CoA dehydrogenase activity
O0235_12530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0235_12535	COG1022	Amp-dependent synthetase and ligase
O0235_12540	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O0235_12575	COG0237	dephospho-CoA kinase activity
O0235_12595	COG0406	alpha-ribazole phosphatase activity
O0235_12605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O0235_12610	COG1193	negative regulation of DNA recombination
O0235_12620	COG2267	carboxylic ester hydrolase activity
O0235_12675	COG1960	acyl-CoA dehydrogenase activity
O0235_12680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O0235_12685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_12690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_12695	COG0427	acetyl-CoA hydrolase
O0235_12710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O0235_12715	COG2201	protein-glutamate methylesterase activity
O0235_12720	COG2201	protein-glutamate methylesterase activity
O0235_12725	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
O0235_12730	COG1406	Chemotaxis phosphatase CheX
O0235_12735	COG0643	Histidine kinase
O0235_12735	COG2198	Histidine kinase
O0235_12740	COG0835	chemotaxis
O0235_12745	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O0235_12770	COG0124	histidyl-tRNA synthetase
O0235_12775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O0235_12815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O0235_12820	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O0235_12825	COG0516	GMP reductase activity
O0235_12825	COG0517	IMP dehydrogenase activity
O0235_12830	COG0674	pyruvate-flavodoxin oxidoreductase activity
O0235_12830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
O0235_12835	COG1013	pyruvate-flavodoxin oxidoreductase activity
O0235_12845	COG0583	DNA-binding transcription factor activity
O0235_12870	COG0596	Alpha beta hydrolase
O0235_12880	COG1024	Enoyl-CoA hydratase
O0235_12885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O0235_12900	COG0316	Belongs to the HesB IscA family
O0235_12915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O0235_12920	COG3608	succinylglutamate desuccinylase aspartoacylase
O0235_12920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
O0235_12945	COG1605	Chorismate mutase
O0235_12945	COG0077	Prephenate dehydratase
O0235_12950	COG0569	domain protein
O0235_12955	COG0569	domain protein
O0235_12970	COG0511	ligase activity, forming carbon-carbon bonds
O0235_12980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O0235_12990	COG0728	peptidoglycan biosynthetic process
O0235_12995	COG0383	alpha-mannosidase activity
O0235_13000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O0235_13005	COG3226	Transcriptional regulator
O0235_13030	COG0785	Cytochrome C biogenesis protein
O0235_13040	COG0443	Heat shock 70 kDa protein
O0235_13070	COG0439	Biotin carboxylase
O0235_13080	COG0129	dihydroxy-acid dehydratase activity
O0235_13090	COG0668	transmembrane transport
O0235_13105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O0235_13125	COG0569	domain protein
O0235_13130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O0235_13135	COG0318	PFAM AMP-dependent synthetase and ligase
O0235_13145	COG0384	phenazine biosynthesis protein PhzF
O0235_13150	COG1058	Belongs to the CinA family
O0235_13150	COG1546	Belongs to the CinA family
O0235_13155	COG0543	2 iron, 2 sulfur cluster binding
O0235_13160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O0235_13175	COG0505	Belongs to the CarA family
O0235_13185	COG0540	Belongs to the ATCase OTCase family
O0235_13190	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O0235_13200	COG0484	heat shock protein binding
O0235_13205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O0235_13235	COG0735	belongs to the Fur family
O0235_13240	COG0835	chemotaxis
O0235_13250	COG0714	Associated with various cellular activities
O0235_13265	COG2045	Belongs to the ComB family
O0235_13270	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O0235_13275	COG0284	orotidine-5'-phosphate decarboxylase activity
O0235_13300	COG0356	it plays a direct role in the translocation of protons across the membrane
O0235_13300	COG0356	it plays a direct role in the translocation of protons across the membrane
O0235_13310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O0235_13315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O0235_13325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O0235_13335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O0235_13340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O0235_13345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O0235_13350	COG1077	Cell shape determining protein MreB Mrl
O0235_13355	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
O0235_13360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O0235_13365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O0235_13375	COG0515	serine threonine protein kinase
O0235_13375	COG2815	serine threonine protein kinase
O0235_13385	COG4608	Belongs to the ABC transporter superfamily
O0235_13390	COG0444	Belongs to the ABC transporter superfamily
O0235_13430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O0235_13450	COG1028	Short-chain dehydrogenase reductase Sdr
O0235_13460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O0235_13465	COG0287	Prephenate dehydrogenase
O0235_13470	COG1994	Peptidase M50
O0235_13490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O0235_13495	COG1199	ATP-dependent helicase activity
O0235_13495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O0235_13505	COG0538	isocitrate dehydrogenase activity
O0235_13510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O0235_13530	COG0442	prolyl-tRNA aminoacylation
O0235_13535	COG1490	D-aminoacyl-tRNA deacylase activity
O0235_13585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0235_13590	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
O0235_13595	COG1733	regulation of RNA biosynthetic process
O0235_13605	COG1201	RNA secondary structure unwinding
O0235_13610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O0235_13615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O0235_13655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O0235_13700	COG4149	molybdate abc transporter
O0235_13705	COG0725	ABC transporter, periplasmic molybdate-binding protein
O0235_13725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O0235_13735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0235_13740	COG0601	transmembrane transport
O0235_13745	COG4166	transmembrane transport
O0235_13750	COG0788	formyltetrahydrofolate deformylase activity
O0235_13790	COG3383	formate dehydrogenase (NAD+) activity
O0235_13795	COG3383	formate dehydrogenase (NAD+) activity
O0235_13800	COG0113	porphobilinogen synthase activity
O0235_13810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O0235_13815	COG0175	sulfate reduction
O0235_13820	COG0529	Catalyzes the synthesis of activated sulfate
O0235_13820	COG2046	Belongs to the sulfate adenylyltransferase family
O0235_13840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_13845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_13870	COG1250	3-hydroxyacyl-CoA dehydrogenase
O0235_13910	COG1058	Belongs to the CinA family
O0235_13910	COG1546	Belongs to the CinA family
O0235_13935	COG0018	arginyl-trna synthetase
O0235_13940	COG3557	Belongs to the UPF0374 family
O0235_13955	COG1136	(ABC) transporter
O0235_13955	COG0577	efflux transmembrane transporter activity
O0235_13990	COG1960	acyl-CoA dehydrogenase activity
O0235_14010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_14015	COG0215	cysteine-tRNA ligase activity
O0235_14020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_14035	COG0358	DNA primase activity
O0235_14045	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O0235_14055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O0235_14065	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O0235_14075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_14085	COG2217	Heavy metal translocating P-type atpase
O0235_14090	COG2217	Heavy metal translocating P-type atpase
O0235_14100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O0235_14115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O0235_14120	COG3409	Peptidoglycan-binding domain 1 protein
O0235_14120	COG0793	Belongs to the peptidase S41A family
O0235_14130	COG0745	RESPONSE REGULATOR receiver
O0235_14135	COG1830	Aldolase
O0235_14140	COG0745	RESPONSE REGULATOR receiver
O0235_14145	COG2205	protein histidine kinase activity
O0235_14150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O0235_14160	COG1045	serine acetyltransferase
O0235_14170	COG0069	glutamate synthase activity
O0235_14170	COG0067	glutamate synthase
O0235_14170	COG0070	glutamate synthase
O0235_14175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0235_14200	COG0346	lactoylglutathione lyase activity
O0235_14225	COG1217	gtp-binding protein TYPA
O0235_14230	COG0740	serine-type endopeptidase activity
O0235_14250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O0235_14260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O0235_14265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O0235_14270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0235_14280	COG0742	ribosomal rna small subunit methyltransferase
O0235_14305	COG0495	leucyl-tRNA aminoacylation
O0235_14315	COG0366	Alpha amylase catalytic
O0235_14325	COG0137	argininosuccinate synthase activity
O0235_14335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O0235_14340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
O0235_14345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O0235_14350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O0235_14355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O0235_14365	COG0167	dihydroorotate dehydrogenase activity
O0235_14375	COG0489	protein tyrosine kinase activity
O0235_14395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O0235_14405	COG0537	adenosine 5'-monophosphoramidase activity
O0235_14420	COG0745	RESPONSE REGULATOR receiver
O0235_14425	COG2205	protein histidine kinase activity
O0235_14430	COG0114	fumarate hydratase activity
O0235_14465	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O0235_14470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O0235_14485	COG4770	biotin carboxylase activity
O0235_14490	COG0439	Biotin carboxylase
O0235_14495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O0235_14515	COG0750	zinc metalloprotease
O0235_14520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O0235_14530	COG0318	PFAM AMP-dependent synthetase and ligase
O0235_14535	COG4948	Mandelate Racemase Muconate Lactonizing
O0235_14540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O0235_14545	COG0596	Alpha beta hydrolase
O0235_14550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O0235_14570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O0235_14575	COG2860	membrane
O0235_14580	COG1418	mRNA catabolic process
O0235_14585	COG1692	metallophosphoesterase
O0235_14590	COG0613	PHP domain protein
O0235_14595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O0235_14600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O0235_14605	COG2890	protein-(glutamine-N5) methyltransferase activity
O0235_14610	COG0561	phosphatase activity
O0235_14620	COG0517	IMP dehydrogenase activity
O0235_14620	COG0516	GMP reductase activity
O0235_14625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O0235_14640	COG0142	geranyltranstransferase activity
O0235_14655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O0235_14660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O0235_14665	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O0235_14670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O0235_14685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O0235_14695	COG0713	ATP synthesis coupled electron transport
O0235_14710	COG0649	NAD binding
O0235_14715	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O0235_14720	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O0235_14725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O0235_14730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O0235_14735	COG1960	acyl-CoA dehydrogenase activity
O0235_14750	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
O0235_14750	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
O0235_14770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O0235_14815	COG0552	protein localization to endoplasmic reticulum
O0235_14820	COG1196	nuclear chromosome segregation
O0235_14825	COG0571	ribonuclease III activity
O0235_14845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O0235_14870	COG0501	Belongs to the peptidase M48B family
O0235_14875	COG1704	LemA family
O0235_14885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0235_14890	COG2070	2-Nitropropane dioxygenase
O0235_14910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O0235_14915	COG0494	nUDIX hydrolase
O0235_14930	COG0131	Imidazoleglycerol-phosphate dehydratase
O0235_14935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O0235_14940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O0235_14950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O0235_14955	COG0140	phosphoribosyl-ATP diphosphatase activity
O0235_14960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
O0235_14960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
O0235_14965	COG0052	Belongs to the universal ribosomal protein uS2 family
O0235_14970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O0235_14975	COG0528	UMP kinase activity
O0235_14980	COG0233	cytoplasmic translational termination
O0235_14990	COG4589	Belongs to the CDS family
O0235_14995	COG0596	Alpha beta hydrolase