locus-tag	class	description
GZ22_00040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZ22_00045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_00050	COG0572	uridine kinase
GZ22_00055	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZ22_00060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZ22_00065	COG0640	Transcriptional regulator
GZ22_00080	COG1404	Belongs to the peptidase S8 family
GZ22_00080	COG4412	M6 family metalloprotease domain protein
GZ22_00090	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_00150	COG0477	Major facilitator Superfamily
GZ22_00165	COG1595	DNA-templated transcription, initiation
GZ22_00170	COG5662	AntiSigma factor
GZ22_00175	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GZ22_00185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZ22_00190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GZ22_00210	COG4585	Histidine kinase
GZ22_00215	COG2197	response regulator
GZ22_00220	COG1131	(ABC) transporter
GZ22_00245	COG3507	Belongs to the glycosyl hydrolase 43 family
GZ22_00255	COG5646	InterPro IPR014922
GZ22_00260	COG2807	transmembrane transport
GZ22_00290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_00295	COG2814	Major facilitator Superfamily
GZ22_00300	COG0640	Transcriptional regulator
GZ22_00305	COG2814	Major facilitator Superfamily
GZ22_00330	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_00365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_00370	COG0747	negative chemotaxis
GZ22_00375	COG0196	riboflavin kinase activity
GZ22_00400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_00405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_00410	COG0456	acetyltransferase
GZ22_00415	COG0589	response to stress
GZ22_00420	COG0659	secondary active sulfate transmembrane transporter activity
GZ22_00435	COG1131	(ABC) transporter
GZ22_00455	COG0656	L-ascorbic acid biosynthetic process
GZ22_00480	COG0789	Transcriptional regulator
GZ22_00490	COG1929	Belongs to the glycerate kinase type-1 family
GZ22_00500	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GZ22_00530	COG1253	flavin adenine dinucleotide binding
GZ22_00535	COG2169	Transcriptional regulator
GZ22_00540	COG0673	inositol 2-dehydrogenase activity
GZ22_00595	COG1252	NADH dehydrogenase
GZ22_00610	COG1309	transcriptional regulator
GZ22_00615	COG0477	Major facilitator Superfamily
GZ22_00625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZ22_00645	COG3226	Transcriptional regulator
GZ22_00655	COG0281	malic enzyme
GZ22_00660	COG3711	transcriptional antiterminator
GZ22_00665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_00665	COG2190	(PTS) system
GZ22_00665	COG1263	PTS System
GZ22_00670	COG2723	6-phospho-beta-galactosidase activity
GZ22_00675	COG4221	oxidoreductase activity
GZ22_00685	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_00690	COG0702	epimerase
GZ22_00700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_00705	COG0778	Nitroreductase
GZ22_00725	COG5577	PFAM Coat F domain
GZ22_00730	COG1063	alcohol dehydrogenase
GZ22_00735	COG1737	Transcriptional regulator
GZ22_00740	COG1486	melibiose metabolic process
GZ22_00745	COG2190	(PTS) system
GZ22_00745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_00745	COG1263	PTS System
GZ22_00760	COG4894	glucomannan catabolic process
GZ22_00770	COG1289	transmembrane transporter activity
GZ22_00780	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GZ22_00785	COG1346	cytolysis
GZ22_00790	COG1380	Effector of murein hydrolase LrgA
GZ22_00795	COG0583	DNA-binding transcription factor activity
GZ22_00805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZ22_00810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZ22_00815	COG1522	sequence-specific DNA binding
GZ22_00820	COG0436	Aminotransferase
GZ22_00825	COG3711	transcriptional antiterminator
GZ22_00830	COG1263	PTS System
GZ22_00830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_00830	COG2190	(PTS) system
GZ22_00835	COG2723	6-phospho-beta-galactosidase activity
GZ22_00845	COG1902	pentaerythritol trinitrate reductase activity
GZ22_00855	COG3711	transcriptional antiterminator
GZ22_00860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_00860	COG2190	(PTS) system
GZ22_00860	COG1263	PTS System
GZ22_00865	COG1733	regulation of RNA biosynthetic process
GZ22_00870	COG2814	Major facilitator Superfamily
GZ22_00875	COG0656	L-ascorbic acid biosynthetic process
GZ22_00890	COG1725	Transcriptional regulator
GZ22_00895	COG1131	(ABC) transporter
GZ22_00925	COG1176	ABC-type spermidine putrescine transport system, permease component I
GZ22_00930	COG1177	transmembrane transport
GZ22_00935	COG3842	ATPase activity
GZ22_00940	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GZ22_00950	COG0596	Alpha beta hydrolase
GZ22_00965	COG0840	transmembrane signaling receptor activity
GZ22_00970	COG0840	transmembrane signaling receptor activity
GZ22_00975	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_00990	COG1876	peptidase activity
GZ22_00995	COG1418	mRNA catabolic process
GZ22_01005	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_01015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GZ22_01020	COG1970	mechanosensitive ion channel activity
GZ22_01025	COG2211	Major facilitator Superfamily
GZ22_01040	COG0667	Aldo Keto reductase
GZ22_01045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GZ22_01050	COG1442	glycosyl transferase family 8
GZ22_01055	COG1827	regulation of RNA biosynthetic process
GZ22_01065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GZ22_01070	COG5506	Protein of unknown function (DUF1694)
GZ22_01075	COG3842	ATPase activity
GZ22_01090	COG2814	Major facilitator Superfamily
GZ22_01095	COG0561	phosphatase activity
GZ22_01100	COG1132	(ABC) transporter
GZ22_01105	COG1473	amidohydrolase
GZ22_01110	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GZ22_01125	COG0679	Auxin Efflux Carrier
GZ22_01130	COG0281	malic enzyme
GZ22_01150	COG1733	regulation of RNA biosynthetic process
GZ22_01155	COG0590	tRNA wobble adenosine to inosine editing
GZ22_01165	COG0492	ferredoxin-NADP+ reductase activity
GZ22_01170	COG0561	phosphatase activity
GZ22_01175	COG0463	Glycosyl transferase, family 2
GZ22_01185	COG4485	Bacterial membrane protein, YfhO
GZ22_01200	COG1072	(Pantothenic acid kinase))
GZ22_01205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_01205	COG1263	PTS System
GZ22_01210	COG0366	Alpha amylase catalytic
GZ22_01215	COG2188	Transcriptional regulator
GZ22_01220	COG1247	-acetyltransferase
GZ22_01235	COG2814	Major facilitator Superfamily
GZ22_01260	COG3871	stress protein (general stress protein 26)
GZ22_01265	COG1834	amidinotransferase
GZ22_01270	COG1979	alcohol dehydrogenase
GZ22_01275	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_01290	COG1725	Transcriptional regulator
GZ22_01295	COG1131	(ABC) transporter
GZ22_01300	COG1131	(ABC) transporter
GZ22_01305	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GZ22_01310	COG1764	response to oxidative stress
GZ22_01315	COG0706	membrane insertase activity
GZ22_01335	COG1131	(ABC) transporter
GZ22_01340	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GZ22_01365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GZ22_01375	COG0716	FMN binding
GZ22_01380	COG0432	Pfam Uncharacterised protein family UPF0047
GZ22_01390	COG0840	transmembrane signaling receptor activity
GZ22_01400	COG1533	DNA photolyase activity
GZ22_01405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GZ22_01415	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GZ22_01425	COG0352	thiamine-phosphate diphosphorylase activity
GZ22_01465	COG0463	Glycosyl transferase, family 2
GZ22_01465	COG0457	Tetratricopeptide repeat
GZ22_01475	COG2814	Major facilitator Superfamily
GZ22_01480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZ22_01485	COG0371	Dehydrogenase
GZ22_01490	COG0436	Aminotransferase
GZ22_01495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZ22_01495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZ22_01510	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZ22_01520	COG0720	synthase
GZ22_01525	COG0602	queuosine metabolic process
GZ22_01530	COG0137	argininosuccinate synthase activity
GZ22_01535	COG0165	Argininosuccinate lyase
GZ22_01540	COG0505	Belongs to the CarA family
GZ22_01545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GZ22_01550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GZ22_01570	COG0307	riboflavin synthase, alpha
GZ22_01580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GZ22_01585	COG0596	Alpha beta hydrolase
GZ22_01610	COG0300	oxidoreductase activity
GZ22_01620	COG0386	Belongs to the glutathione peroxidase family
GZ22_01640	COG1278	Cold shock
GZ22_01650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZ22_01660	COG2084	Dehydrogenase
GZ22_01665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZ22_01675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GZ22_01685	COG0463	Glycosyl transferase, family 2
GZ22_01700	COG0745	RESPONSE REGULATOR receiver
GZ22_01705	COG5002	protein histidine kinase activity
GZ22_01705	COG3850	Histidine kinase
GZ22_01725	COG0577	efflux transmembrane transporter activity
GZ22_01730	COG1136	(ABC) transporter
GZ22_01740	COG0018	arginyl-trna synthetase
GZ22_01755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZ22_01760	COG1914	H( )-stimulated, divalent metal cation uptake system
GZ22_01765	COG1597	lipid kinase activity
GZ22_01780	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_01800	COG0513	Belongs to the DEAD box helicase family
GZ22_01805	COG3402	PFAM membrane-flanked domain
GZ22_01810	COG3428	Bacterial PH domain
GZ22_01815	COG0705	Rhomboid family
GZ22_01820	COG0736	holo-[acyl-carrier-protein] synthase activity
GZ22_01825	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GZ22_01825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GZ22_01830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GZ22_01835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GZ22_01840	COG0864	Transcriptional regulator
GZ22_01845	COG2337	Toxic component of a toxin-antitoxin (TA) module
GZ22_01850	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_01855	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_01860	COG2172	sigma factor antagonist activity
GZ22_01865	COG2208	phosphoserine phosphatase activity
GZ22_01870	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_01875	COG2172	sigma factor antagonist activity
GZ22_01880	COG1191	sigma factor activity
GZ22_01885	COG2208	phosphoserine phosphatase activity
GZ22_01890	COG2183	response to ionizing radiation
GZ22_01900	COG3091	SprT-like family
GZ22_01990	COG0802	atpase or kinase
GZ22_01995	COG1214	PFAM Peptidase M22, glycoprotease
GZ22_02000	COG0456	acetyltransferase
GZ22_02005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZ22_02010	COG0488	(ABC) transporter
GZ22_02015	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GZ22_02020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZ22_02025	COG0390	transport system, permease component
GZ22_02040	COG2814	Major facilitator Superfamily
GZ22_02055	COG1733	regulation of RNA biosynthetic process
GZ22_02065	COG0583	DNA-binding transcription factor activity
GZ22_02070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZ22_02085	COG1609	Transcriptional regulator
GZ22_02090	COG1811	Na channel or pump
GZ22_02110	COG0789	Transcriptional regulator
GZ22_02125	COG1620	l-lactate permease
GZ22_02130	COG0039	L-malate dehydrogenase activity
GZ22_02140	COG2368	4-hydroxyphenylacetate
GZ22_02155	COG1396	sequence-specific DNA binding
GZ22_02165	COG1476	TRANSCRIPTIONal
GZ22_02175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GZ22_02180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZ22_02180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZ22_02185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZ22_02185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZ22_02205	COG0833	amino acid
GZ22_02210	COG1307	EDD domain protein, DegV family
GZ22_02240	COG1115	amino acid carrier protein
GZ22_02280	COG0456	acetyltransferase
GZ22_02290	COG1266	CAAX protease self-immunity
GZ22_02300	COG0459	protein refolding
GZ22_02310	COG2268	Band 7 protein
GZ22_02315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GZ22_02325	COG4336	lyase activity
GZ22_02360	COG2807	transmembrane transport
GZ22_02375	COG1486	melibiose metabolic process
GZ22_02395	COG2207	Transcriptional regulator
GZ22_02395	COG3708	Transcriptional regulator
GZ22_02405	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GZ22_02415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZ22_02425	COG0745	RESPONSE REGULATOR receiver
GZ22_02430	COG2814	Major facilitator Superfamily
GZ22_02440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_02450	COG0431	NADPH-dependent FMN reductase
GZ22_02455	COG0730	response to heat
GZ22_02460	COG1335	isochorismatase
GZ22_02480	COG3959	Transketolase, thiamine diphosphate binding domain
GZ22_02485	COG3958	Transketolase
GZ22_02490	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_02505	COG2186	Transcriptional regulator
GZ22_02520	COG1116	anion transmembrane transporter activity
GZ22_02530	COG1263	PTS System
GZ22_02530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_02530	COG2190	(PTS) system
GZ22_02535	COG2723	6-phospho-beta-galactosidase activity
GZ22_02550	COG0693	protein deglycase activity
GZ22_02555	COG1473	amidohydrolase
GZ22_02570	COG1069	ribulokinase activity
GZ22_02580	COG1011	Hydrolase
GZ22_02595	COG1609	Transcriptional regulator
GZ22_02600	COG1653	transport
GZ22_02610	COG1175	transmembrane transport
GZ22_02615	COG0395	ABC-type sugar transport system, permease component
GZ22_02625	COG3534	alpha-L-arabinofuranosidase
GZ22_02630	COG0371	Dehydrogenase
GZ22_02635	COG0647	UMP catabolic process
GZ22_02640	COG3940	Belongs to the glycosyl hydrolase 43 family
GZ22_02690	COG1280	lysine exporter protein (LysE YggA)
GZ22_02710	COG1733	regulation of RNA biosynthetic process
GZ22_02715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_02720	COG0431	NADPH-dependent FMN reductase
GZ22_02755	COG1113	amino acid transport
GZ22_02760	COG1113	amino acid transport
GZ22_02775	COG3290	protein histidine kinase activity
GZ22_02780	COG4565	transcriptional regulatory protein
GZ22_02785	COG2851	Citrate transporter
GZ22_02790	COG0693	protein deglycase activity
GZ22_02795	COG2910	NAD(P)H-binding
GZ22_02800	COG1959	2 iron, 2 sulfur cluster binding
GZ22_02810	COG1959	2 iron, 2 sulfur cluster binding
GZ22_02820	COG5002	protein histidine kinase activity
GZ22_02825	COG0745	RESPONSE REGULATOR receiver
GZ22_02835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GZ22_02840	COG1696	Membrane protein involved in D-alanine export
GZ22_02845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZ22_02850	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GZ22_02860	COG2153	protein acetylation
GZ22_02865	COG2364	Membrane
GZ22_02870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZ22_02875	COG4989	oxidoreductase activity
GZ22_02895	COG3402	PFAM membrane-flanked domain
GZ22_02935	COG0840	transmembrane signaling receptor activity
GZ22_02950	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZ22_02965	COG0490	domain, Protein
GZ22_02970	COG0475	glutathione-regulated potassium exporter activity
GZ22_02975	COG0714	Associated with various cellular activities
GZ22_02980	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GZ22_02985	COG1305	Transglutaminase-like
GZ22_02990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GZ22_02990	COG0519	Catalyzes the synthesis of GMP from XMP
GZ22_03005	COG2252	PERMEase
GZ22_03015	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GZ22_03025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GZ22_03035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZ22_03040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GZ22_03045	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZ22_03055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZ22_03060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GZ22_03065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GZ22_03070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GZ22_03075	COG0138	bifunctional purine biosynthesis protein purh
GZ22_03080	COG0151	Belongs to the GarS family
GZ22_03090	COG4496	protein, YerC YecD
GZ22_03095	COG0673	inositol 2-dehydrogenase activity
GZ22_03100	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GZ22_03105	COG0210	DNA helicase
GZ22_03110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GZ22_03115	COG4851	CamS sex pheromone cAM373 precursor
GZ22_03130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZ22_03135	COG0154	amidase activity
GZ22_03140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZ22_03155	COG1597	lipid kinase activity
GZ22_03160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GZ22_03190	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GZ22_03195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZ22_03200	COG5658	integral membrane protein
GZ22_03210	COG0534	Mate efflux family protein
GZ22_03220	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GZ22_03225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GZ22_03235	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_03240	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GZ22_03255	COG0583	DNA-binding transcription factor activity
GZ22_03260	COG0114	fumarate hydratase activity
GZ22_03265	COG2188	Transcriptional regulator
GZ22_03275	COG2723	6-phospho-beta-galactosidase activity
GZ22_03300	COG3842	ATPase activity
GZ22_03305	COG1176	ABC-type spermidine putrescine transport system, permease component I
GZ22_03320	COG0596	Alpha beta hydrolase
GZ22_03330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_03340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZ22_03345	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GZ22_03350	COG0456	acetyltransferase
GZ22_03355	COG0505	Belongs to the CarA family
GZ22_03375	COG1653	transport
GZ22_03380	COG1175	transmembrane transport
GZ22_03385	COG3833	ABC-type maltose transport systems, permease component
GZ22_03405	COG2226	methyltransferase
GZ22_03410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GZ22_03445	COG0840	transmembrane signaling receptor activity
GZ22_03450	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_03460	COG3401	FG-GAP repeat protein
GZ22_03465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZ22_03515	COG1228	amidohydrolase
GZ22_03520	COG0471	metal ion transport
GZ22_03535	COG0598	Magnesium transport protein CorA
GZ22_03545	COG2188	Transcriptional regulator
GZ22_03550	COG1486	melibiose metabolic process
GZ22_03555	COG3394	polysaccharide catabolic process
GZ22_03560	COG1263	PTS System
GZ22_03560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_03585	COG1077	Cell shape determining protein MreB Mrl
GZ22_03590	COG2340	Cysteine-rich secretory protein family
GZ22_03605	COG1619	proteins homologs of microcin C7 resistance protein MccF
GZ22_03610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GZ22_03620	COG1295	ribonuclease BN
GZ22_03630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZ22_03635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZ22_03640	COG0765	amino acid transport
GZ22_03645	COG0477	Major facilitator Superfamily
GZ22_03670	COG0583	DNA-binding transcription factor activity
GZ22_03675	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GZ22_03680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZ22_03685	COG0542	response to heat
GZ22_03695	COG1131	(ABC) transporter
GZ22_03700	COG1725	Transcriptional regulator
GZ22_03710	COG1442	glycosyl transferase family 8
GZ22_03715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_03740	COG1115	amino acid carrier protein
GZ22_03750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GZ22_03770	COG1335	isochorismatase
GZ22_03775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GZ22_03780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GZ22_03785	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZ22_03805	COG1132	(ABC) transporter
GZ22_03820	COG1368	sulfuric ester hydrolase activity
GZ22_03835	COG1063	alcohol dehydrogenase
GZ22_03840	COG0628	permease
GZ22_03845	COG1090	epimerase
GZ22_03850	COG2137	regulation of response to DNA damage stimulus
GZ22_03870	COG1988	membrane-bound metal-dependent
GZ22_03875	COG1194	a g-specific adenine glycosylase
GZ22_03885	COG3557	Belongs to the UPF0374 family
GZ22_03890	COG1132	(ABC) transporter
GZ22_03895	COG4129	membrane
GZ22_03910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GZ22_03925	COG2096	Adenosyltransferase
GZ22_03930	COG0735	belongs to the Fur family
GZ22_04025	COG0745	RESPONSE REGULATOR receiver
GZ22_04030	COG2205	protein histidine kinase activity
GZ22_04035	COG1136	(ABC) transporter
GZ22_04040	COG0577	efflux transmembrane transporter activity
GZ22_04050	COG0604	alcohol dehydrogenase
GZ22_04055	COG1966	Carbon starvation protein
GZ22_04060	COG0667	Aldo Keto reductase
GZ22_04095	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZ22_04105	COG0735	belongs to the Fur family
GZ22_04110	COG3443	Belongs to the bacterial solute-binding protein 9 family
GZ22_04115	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZ22_04120	COG1121	(ABC) transporter
GZ22_04125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZ22_04130	COG2376	Dihydroxyacetone kinase
GZ22_04140	COG2070	2-Nitropropane dioxygenase
GZ22_04145	COG1051	belongs to the nudix hydrolase family
GZ22_04170	COG4608	Belongs to the ABC transporter superfamily
GZ22_04175	COG0444	Belongs to the ABC transporter superfamily
GZ22_04190	COG0747	negative chemotaxis
GZ22_04195	COG1473	amidohydrolase
GZ22_04200	COG0626	cystathionine gamma-synthase activity
GZ22_04205	COG0626	cystathionine gamma-synthase activity
GZ22_04210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GZ22_04215	COG0110	maltose O-acetyltransferase activity
GZ22_04220	COG0697	spore germination
GZ22_04225	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_04230	COG1454	alcohol dehydrogenase
GZ22_04255	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GZ22_04260	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_04275	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GZ22_04280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZ22_04295	COG0667	Aldo Keto reductase
GZ22_04300	COG2207	Transcriptional regulator
GZ22_04310	COG2409	Drug exporters of the RND superfamily
GZ22_04320	COG1764	response to oxidative stress
GZ22_04325	COG1846	Transcriptional regulator
GZ22_04330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZ22_04355	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_04360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZ22_04365	COG0604	alcohol dehydrogenase
GZ22_04375	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_04405	COG1271	oxidase subunit
GZ22_04410	COG1294	oxidase, subunit
GZ22_04415	COG4988	ABC transporter
GZ22_04420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GZ22_04430	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_04440	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_04445	COG0622	Phosphoesterase
GZ22_04450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZ22_04455	COG0398	Pfam SNARE associated Golgi protein
GZ22_04460	COG0714	Associated with various cellular activities
GZ22_04485	COG0840	transmembrane signaling receptor activity
GZ22_04490	COG0778	Nitroreductase
GZ22_04515	COG2766	serine protein kinase
GZ22_04520	COG0730	response to heat
GZ22_04525	COG0583	DNA-binding transcription factor activity
GZ22_04535	COG0567	Dehydrogenase, E1 component
GZ22_04540	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ22_04545	COG0697	spore germination
GZ22_04550	COG0531	amino acid
GZ22_04560	COG2718	Belongs to the UPF0229 family
GZ22_04565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZ22_04570	COG0288	reversible hydration of carbon dioxide
GZ22_04575	COG1132	(ABC) transporter
GZ22_04580	COG1132	(ABC) transporter
GZ22_04585	COG1191	sigma factor activity
GZ22_04595	COG3153	acetyltransferase
GZ22_04595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZ22_04620	COG1854	S-ribosylhomocysteine lyase activity
GZ22_04625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZ22_04630	COG0626	cystathionine gamma-synthase activity
GZ22_04645	COG2719	SpoVR family
GZ22_04675	COG2226	methyltransferase
GZ22_04690	COG3663	DNA glycosylase
GZ22_04695	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_04710	COG1131	(ABC) transporter
GZ22_04715	COG3223	Belongs to the PsiE family
GZ22_04720	COG0024	Methionine aminopeptidase
GZ22_04725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GZ22_04735	COG2814	Major facilitator Superfamily
GZ22_04745	COG1876	peptidase activity
GZ22_04750	COG0114	fumarate hydratase activity
GZ22_04760	COG2508	Transcriptional regulator
GZ22_04770	COG3679	Belongs to the UPF0342 family
GZ22_04775	COG0420	3'-5' exonuclease activity
GZ22_04785	COG1510	regulation of RNA biosynthetic process
GZ22_04790	COG3481	metal-dependent phosphohydrolase, HD sub domain
GZ22_04825	COG4175	Glycine betaine
GZ22_04825	COG0517	IMP dehydrogenase activity
GZ22_04835	COG2113	Glycine betaine
GZ22_04860	COG1595	DNA-templated transcription, initiation
GZ22_04880	COG4980	gas vesicle protein
GZ22_04885	COG0537	adenosine 5'-monophosphoramidase activity
GZ22_04890	COG1131	(ABC) transporter
GZ22_04895	COG4473	ABC transporter
GZ22_04905	COG1473	amidohydrolase
GZ22_04920	COG2329	Antibiotic biosynthesis monooxygenase
GZ22_04925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZ22_04930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GZ22_04950	COG1234	tRNA 3'-trailer cleavage
GZ22_04955	COG0095	Lipoate-protein ligase
GZ22_04965	COG4903	ComK protein
GZ22_04975	COG0398	Pfam SNARE associated Golgi protein
GZ22_04985	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GZ22_04990	COG1074	ATP-dependent DNA helicase activity
GZ22_05010	COG2311	Membrane
GZ22_05020	COG0367	asparagine synthase
GZ22_05025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZ22_05040	COG2199	diguanylate cyclase activity
GZ22_05040	COG2203	Gaf domain
GZ22_05045	COG0745	RESPONSE REGULATOR receiver
GZ22_05065	COG0561	phosphatase activity
GZ22_05070	COG1073	alpha beta
GZ22_05075	COG2151	metal-sulfur cluster biosynthetic enzyme
GZ22_05100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZ22_05110	COG0180	Tryptophanyl-tRNA synthetase
GZ22_05120	COG4166	transmembrane transport
GZ22_05125	COG0601	transmembrane transport
GZ22_05130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZ22_05135	COG0444	Belongs to the ABC transporter superfamily
GZ22_05140	COG4608	Belongs to the ABC transporter superfamily
GZ22_05150	COG0456	acetyltransferase
GZ22_05155	COG1393	Belongs to the ArsC family
GZ22_05160	COG4862	establishment of competence for transformation
GZ22_05170	COG1164	Oligoendopeptidase f
GZ22_05190	COG2346	COG2346, Truncated hemoglobins
GZ22_05195	COG4116	CYTH
GZ22_05200	COG2357	RelA SpoT domain protein
GZ22_05205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GZ22_05210	COG0564	pseudouridine synthase activity
GZ22_05215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GZ22_05220	COG0772	Belongs to the SEDS family
GZ22_05225	COG2239	Acts as a magnesium transporter
GZ22_05250	COG2323	membrane
GZ22_05255	COG2153	protein acetylation
GZ22_05260	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GZ22_05265	COG2382	esterase
GZ22_05270	COG0346	lactoylglutathione lyase activity
GZ22_05275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZ22_05285	COG1121	(ABC) transporter
GZ22_05290	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZ22_05300	COG0346	lactoylglutathione lyase activity
GZ22_05320	COG1278	Cold shock
GZ22_05330	COG2814	Major facilitator Superfamily
GZ22_05335	COG1309	transcriptional regulator
GZ22_05375	COG1113	amino acid transport
GZ22_05380	COG1846	Transcriptional regulator
GZ22_05385	COG0456	acetyltransferase
GZ22_05395	COG0561	phosphatase activity
GZ22_05400	COG0346	lactoylglutathione lyase activity
GZ22_05405	COG0110	maltose O-acetyltransferase activity
GZ22_05420	COG1733	regulation of RNA biosynthetic process
GZ22_05430	COG0667	Aldo Keto reductase
GZ22_05435	COG1960	acyl-CoA dehydrogenase activity
GZ22_05450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZ22_05455	COG2011	ABC-type metal ion transport system permease component
GZ22_05460	COG1464	Belongs to the NlpA lipoprotein family
GZ22_05465	COG4585	Histidine kinase
GZ22_05470	COG2197	response regulator
GZ22_05485	COG0584	glycerophosphoryl diester phosphodiesterase
GZ22_05495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZ22_05520	COG2828	Protein conserved in bacteria
GZ22_05525	COG0583	DNA-binding transcription factor activity
GZ22_05530	COG2851	Citrate transporter
GZ22_05545	COG4753	response regulator
GZ22_05545	COG2207	Transcriptional regulator
GZ22_05550	COG2972	Histidine kinase
GZ22_05570	COG3250	beta-galactosidase activity
GZ22_05620	COG3883	PFAM NLP P60 protein
GZ22_05620	COG0791	NLP P60 protein
GZ22_05640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GZ22_05650	COG1176	ABC-type spermidine putrescine transport system, permease component I
GZ22_05685	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_05690	COG1846	Transcriptional regulator
GZ22_05695	COG0778	Nitroreductase
GZ22_05705	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GZ22_05710	COG2076	Multidrug Resistance protein
GZ22_05715	COG2076	Multidrug Resistance protein
GZ22_05785	COG1397	ADP-ribosylglycohydrolase
GZ22_05805	COG2135	peptidase activity
GZ22_05810	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GZ22_05815	COG1122	ATPase activity
GZ22_05820	COG4721	ABC-type cobalt transport system, permease component
GZ22_05830	COG0598	Magnesium transport protein CorA
GZ22_05840	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_05840	COG2202	Pas domain
GZ22_05865	COG1714	RDD family
GZ22_05880	COG1597	lipid kinase activity
GZ22_05885	COG1316	TRANSCRIPTIONal
GZ22_05900	COG0515	serine threonine protein kinase
GZ22_05915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GZ22_05920	COG0066	3-isopropylmalate dehydratase activity
GZ22_05925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GZ22_05930	COG0473	3-isopropylmalate dehydrogenase activity
GZ22_05935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZ22_05940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GZ22_05945	COG0440	acetolactate synthase activity
GZ22_05950	COG0028	Belongs to the TPP enzyme family
GZ22_05955	COG0129	dihydroxy-acid dehydratase activity
GZ22_05970	COG1131	(ABC) transporter
GZ22_05975	COG0842	Transport permease protein
GZ22_05980	COG4585	Histidine kinase
GZ22_05990	COG3104	oligopeptide transport
GZ22_05995	COG3859	Proton-coupled thiamine transporter YuaJ
GZ22_06015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZ22_06025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZ22_06040	COG0436	Aminotransferase
GZ22_06060	COG1408	metallophosphoesterase
GZ22_06065	COG1272	protein, Hemolysin III
GZ22_06075	COG2171	N-acyltransferase activity
GZ22_06080	COG1473	amidohydrolase
GZ22_06085	COG0668	transmembrane transport
GZ22_06090	COG0450	alkyl hydroperoxide reductase
GZ22_06100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZ22_06105	COG1132	(ABC) transporter
GZ22_06110	COG1132	(ABC) transporter
GZ22_06115	COG1271	oxidase subunit
GZ22_06120	COG1294	oxidase, subunit
GZ22_06125	COG0569	domain protein
GZ22_06130	COG0028	Belongs to the TPP enzyme family
GZ22_06135	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GZ22_06150	COG0561	phosphatase activity
GZ22_06155	COG0242	peptide deformylase activity
GZ22_06160	COG0497	DNA recombination
GZ22_06170	COG0022	dehydrogenase e1 component
GZ22_06175	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ22_06190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZ22_06195	COG0726	polysaccharide deacetylase
GZ22_06200	COG1982	Orn Lys Arg decarboxylase major
GZ22_06205	COG4476	Belongs to the UPF0223 family
GZ22_06210	COG4493	Belongs to the UPF0637 family
GZ22_06220	COG0483	inositol monophosphate 1-phosphatase activity
GZ22_06235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GZ22_06240	COG4838	Belongs to the UPF0358 family
GZ22_06250	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GZ22_06270	COG2340	Cysteine-rich secretory protein family
GZ22_06285	COG3679	Belongs to the UPF0342 family
GZ22_06290	COG4471	UPF0298 protein
GZ22_06295	COG0742	ribosomal rna small subunit methyltransferase
GZ22_06300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GZ22_06305	COG3314	Sporulation integral membrane protein YlbJ
GZ22_06310	COG3480	Lon protease (S16) C-terminal proteolytic domain
GZ22_06315	COG1323	Belongs to the UPF0348 family
GZ22_06320	COG1399	metal-binding, possibly nucleic acid-binding protein
GZ22_06335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GZ22_06345	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GZ22_06350	COG2001	Belongs to the MraZ family
GZ22_06355	COG0275	rRNA processing
GZ22_06360	COG4839	cell division protein FtsL
GZ22_06370	COG0768	penicillin binding
GZ22_06375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GZ22_06380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GZ22_06385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZ22_06390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GZ22_06395	COG0772	Belongs to the SEDS family
GZ22_06405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GZ22_06410	COG0849	cell division
GZ22_06415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GZ22_06425	COG1191	sigma factor activity
GZ22_06430	COG1191	sigma factor activity
GZ22_06435	COG1873	PFAM PRC-barrel domain
GZ22_06445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GZ22_06450	COG1799	cell septum assembly
GZ22_06455	COG0762	integral membrane protein
GZ22_06460	COG2302	S4 RNA-binding domain
GZ22_06465	COG3599	regulation of cell shape
GZ22_06470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GZ22_06475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GZ22_06480	COG0564	pseudouridine synthase activity
GZ22_06485	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GZ22_06495	COG0540	Belongs to the ATCase OTCase family
GZ22_06500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GZ22_06505	COG0505	Belongs to the CarA family
GZ22_06515	COG0543	2 iron, 2 sulfur cluster binding
GZ22_06520	COG0167	dihydroorotate dehydrogenase activity
GZ22_06525	COG0284	orotidine-5'-phosphate decarboxylase activity
GZ22_06530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GZ22_06540	COG0028	Belongs to the TPP enzyme family
GZ22_06565	COG1266	CAAX protease self-immunity
GZ22_06575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GZ22_06580	COG1561	YicC-like family, N-terminal region
GZ22_06585	COG2052	Domain of unknown function (DUF370)
GZ22_06590	COG0194	GDP metabolic process
GZ22_06595	COG1758	RNA polymerase activity
GZ22_06600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GZ22_06605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GZ22_06610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GZ22_06615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZ22_06615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GZ22_06620	COG0631	protein serine/threonine phosphatase activity
GZ22_06625	COG2815	serine threonine protein kinase
GZ22_06625	COG0515	serine threonine protein kinase
GZ22_06630	COG1162	GTPase activity
GZ22_06635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZ22_06640	COG1564	THIamine pyrophosphokinase
GZ22_06650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GZ22_06655	COG1302	Protein conserved in bacteria
GZ22_06660	COG1461	Dihydroxyacetone kinase
GZ22_06665	COG1760	l-serine dehydratase
GZ22_06670	COG1760	l-serine dehydratase
GZ22_06675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GZ22_06685	COG0416	fatty acid biosynthetic process
GZ22_06690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GZ22_06695	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_06700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZ22_06705	COG0571	ribonuclease III activity
GZ22_06710	COG4840	Belongs to the UPF0435 family
GZ22_06715	COG1196	nuclear chromosome segregation
GZ22_06720	COG0552	protein localization to endoplasmic reticulum
GZ22_06725	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GZ22_06730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GZ22_06735	COG0228	four-way junction DNA binding
GZ22_06740	COG1837	Belongs to the UPF0109 family
GZ22_06750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GZ22_06755	COG0336	Belongs to the RNA methyltransferase TrmD family
GZ22_06760	COG0335	large ribosomal subunit rRNA binding
GZ22_06770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GZ22_06775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZ22_06785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GZ22_06790	COG0045	succinate-CoA ligase (ADP-forming) activity
GZ22_06795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GZ22_06800	COG0758	DNA mediated transformation
GZ22_06805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZ22_06810	COG4974	Belongs to the 'phage' integrase family
GZ22_06815	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GZ22_06820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GZ22_06825	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GZ22_06830	COG1815	bacterial-type flagellum-dependent cell motility
GZ22_06835	COG1558	bacterial-type flagellum-dependent cell motility
GZ22_06840	COG1677	Flagellar hook-basal body complex protein FliE
GZ22_06845	COG1766	The M ring may be actively involved in energy transduction
GZ22_06850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZ22_06860	COG1157	protein secretion by the type III secretion system
GZ22_06865	COG2882	bacterial-type flagellum organization
GZ22_06880	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GZ22_06885	COG4786	Flagellar basal body rod
GZ22_06890	COG1582	Flagellar protein (FlbD)
GZ22_06900	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZ22_06905	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZ22_06905	COG1776	CheC inhibitor of MCP methylation
GZ22_06910	COG2201	protein-glutamate methylesterase activity
GZ22_06915	COG3190	flagellar
GZ22_06920	COG1338	Plays a role in the flagellum-specific transport system
GZ22_06925	COG1987	bacterial-type flagellum assembly
GZ22_06930	COG1684	flagellar biosynthetic protein fliR
GZ22_06935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GZ22_06940	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GZ22_06945	COG1419	protein localization to endoplasmic reticulum
GZ22_06955	COG2201	protein-glutamate methylesterase activity
GZ22_06960	COG0643	Histidine kinase
GZ22_06960	COG2198	Histidine kinase
GZ22_06965	COG0835	chemotaxis
GZ22_06970	COG1776	CheC inhibitor of MCP methylation
GZ22_06975	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GZ22_06980	COG1191	sigma factor activity
GZ22_06990	COG0052	Belongs to the universal ribosomal protein uS2 family
GZ22_06995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GZ22_07000	COG0528	UMP kinase activity
GZ22_07005	COG0233	cytoplasmic translational termination
GZ22_07015	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GZ22_07020	COG4589	Belongs to the CDS family
GZ22_07025	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GZ22_07030	COG0750	zinc metalloprotease
GZ22_07035	COG0442	prolyl-tRNA aminoacylation
GZ22_07040	COG2176	DNA-directed DNA polymerase activity
GZ22_07045	COG0779	Required for maturation of 30S ribosomal subunits
GZ22_07050	COG0195	Participates in both transcription termination and antitermination
GZ22_07055	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GZ22_07060	COG1358	cellular component organization or biogenesis
GZ22_07065	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GZ22_07070	COG1550	Protein conserved in bacteria
GZ22_07075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GZ22_07085	COG0196	riboflavin kinase activity
GZ22_07090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GZ22_07095	COG1185	polyribonucleotide nucleotidyltransferase activity
GZ22_07100	COG0726	polysaccharide deacetylase
GZ22_07105	COG0612	Peptidase, M16
GZ22_07110	COG1873	PFAM PRC-barrel domain
GZ22_07115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZ22_07120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GZ22_07125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZ22_07130	COG0527	aspartate kinase activity
GZ22_07135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZ22_07140	COG0740	serine-type endopeptidase activity
GZ22_07150	COG1674	ftsk spoiiie
GZ22_07175	COG0612	Peptidase, M16
GZ22_07180	COG0612	Peptidase, M16
GZ22_07185	COG0300	oxidoreductase activity
GZ22_07200	COG1426	Protein conserved in bacteria
GZ22_07210	COG1546	Belongs to the CinA family
GZ22_07210	COG1058	Belongs to the CinA family
GZ22_07215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GZ22_07220	COG1418	mRNA catabolic process
GZ22_07225	COG1692	metallophosphoesterase
GZ22_07230	COG2359	stage V sporulation protein S
GZ22_07235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZ22_07240	COG4550	Control of competence regulator ComK, YlbF/YmcA
GZ22_07250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GZ22_07255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GZ22_07265	COG0783	Belongs to the Dps family
GZ22_07275	COG1923	regulation of RNA biosynthetic process
GZ22_07280	COG0464	growth
GZ22_07285	COG0697	spore germination
GZ22_07290	COG0531	amino acid
GZ22_07300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GZ22_07305	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GZ22_07310	COG0789	Transcriptional regulator
GZ22_07315	COG0174	glutamine synthetase
GZ22_07340	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_07360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GZ22_07370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GZ22_07375	COG4224	UPF0291 protein
GZ22_07390	COG3763	UPF0154 protein
GZ22_07400	COG1971	Probably functions as a manganese efflux pump
GZ22_07420	COG0785	Cytochrome C biogenesis protein
GZ22_07430	COG2201	protein-glutamate methylesterase activity
GZ22_07435	COG4846	Membrane protein involved in cytochrome C biogenesis
GZ22_07440	COG4191	Histidine kinase
GZ22_07450	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GZ22_07460	COG0464	growth
GZ22_07465	COG0824	Thioesterase
GZ22_07475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GZ22_07480	COG1469	GTP cyclohydrolase I activity
GZ22_07485	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZ22_07490	COG0517	IMP dehydrogenase activity
GZ22_07490	COG1125	glycine betaine transport
GZ22_07495	COG1174	glycine betaine transport
GZ22_07500	COG1832	CoA-binding protein
GZ22_07505	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GZ22_07510	COG0187	DNA topoisomerase II activity
GZ22_07515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZ22_07525	COG0745	RESPONSE REGULATOR receiver
GZ22_07530	COG5002	protein histidine kinase activity
GZ22_07530	COG3850	Histidine kinase
GZ22_07560	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GZ22_07565	COG0723	plastoquinol--plastocyanin reductase activity
GZ22_07565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZ22_07585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZ22_07590	COG0583	DNA-binding transcription factor activity
GZ22_07595	COG2814	Major facilitator Superfamily
GZ22_07605	COG1309	transcriptional regulator
GZ22_07610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GZ22_07615	COG0656	L-ascorbic acid biosynthetic process
GZ22_07625	COG0656	L-ascorbic acid biosynthetic process
GZ22_07635	COG2076	Multidrug Resistance protein
GZ22_07640	COG2076	Multidrug Resistance protein
GZ22_07645	COG0753	catalase activity
GZ22_07650	COG2223	nitrite transmembrane transporter activity
GZ22_07670	COG1846	Transcriptional regulator
GZ22_07670	COG0456	acetyltransferase
GZ22_07680	COG0840	transmembrane signaling receptor activity
GZ22_07685	COG0840	transmembrane signaling receptor activity
GZ22_07690	COG1063	alcohol dehydrogenase
GZ22_07700	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_07705	COG0110	maltose O-acetyltransferase activity
GZ22_07720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZ22_07730	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GZ22_07740	COG0131	Imidazoleglycerol-phosphate dehydratase
GZ22_07750	COG0107	imidazoleglycerol-phosphate synthase activity
GZ22_07790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_07795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZ22_07800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZ22_07805	COG0583	DNA-binding transcription factor activity
GZ22_07815	COG0493	'glutamate synthase
GZ22_07820	COG0840	transmembrane signaling receptor activity
GZ22_07830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZ22_07845	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_07850	COG1657	PFAM Prenyltransferase squalene oxidase
GZ22_07860	COG0708	Exodeoxyribonuclease III
GZ22_07865	COG2027	D-alanyl-D-alanine carboxypeptidase
GZ22_07885	COG0346	lactoylglutathione lyase activity
GZ22_07890	COG0516	GMP reductase activity
GZ22_07890	COG0517	IMP dehydrogenase activity
GZ22_07915	COG1114	Component of the transport system for branched-chain amino acids
GZ22_07950	COG1473	amidohydrolase
GZ22_07960	COG1472	Belongs to the glycosyl hydrolase 3 family
GZ22_07965	COG3876	Protein conserved in bacteria
GZ22_07970	COG0583	DNA-binding transcription factor activity
GZ22_07985	COG0438	transferase activity, transferring glycosyl groups
GZ22_07995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZ22_07995	COG0723	plastoquinol--plastocyanin reductase activity
GZ22_08000	COG1254	Belongs to the acylphosphatase family
GZ22_08005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZ22_08005	COG0723	plastoquinol--plastocyanin reductase activity
GZ22_08030	COG3180	Ammonia monooxygenase
GZ22_08035	COG0861	Integral membrane protein TerC family
GZ22_08040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZ22_08040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZ22_08055	COG0419	ATPase involved in DNA repair
GZ22_08060	COG0420	3'-5' exonuclease activity
GZ22_08065	COG3403	YqcI/YcgG family
GZ22_08085	COG1368	sulfuric ester hydrolase activity
GZ22_08100	COG4479	Belongs to the UPF0346 family
GZ22_08115	COG1418	mRNA catabolic process
GZ22_08120	COG1801	Protein of unknown function DUF72
GZ22_08125	COG1278	Cold shock
GZ22_08130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GZ22_08135	COG0328	RNA-DNA hybrid ribonuclease activity
GZ22_08150	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GZ22_08155	COG0116	Belongs to the methyltransferase superfamily
GZ22_08170	COG4474	Belongs to the UPF0398 family
GZ22_08180	COG1304	FMN binding
GZ22_08220	COG0295	cytidine deaminase activity
GZ22_08245	COG3331	DNA recombination
GZ22_08250	COG4499	WXG100 protein secretion system (Wss), protein YukC
GZ22_08250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZ22_08255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GZ22_08260	COG3935	DnaD domain protein
GZ22_08265	COG0017	Asparaginyl-tRNA synthetase
GZ22_08280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZ22_08280	COG1199	ATP-dependent helicase activity
GZ22_08285	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GZ22_08290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GZ22_08305	COG0617	tRNA 3'-terminal CCA addition
GZ22_08310	COG0438	transferase activity, transferring glycosyl groups
GZ22_08315	COG1803	Methylglyoxal synthase
GZ22_08320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GZ22_08325	COG1694	Mazg nucleotide pyrophosphohydrolase
GZ22_08330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZ22_08335	COG0693	protein deglycase activity
GZ22_08340	COG2738	Putative neutral zinc metallopeptidase
GZ22_08350	COG4347	Protein of unknown function (DUF1405)
GZ22_08360	COG0457	Tetratricopeptide repeat
GZ22_08365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GZ22_08370	COG0287	Prephenate dehydrogenase
GZ22_08380	COG4401	Chorismate mutase type I
GZ22_08385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GZ22_08390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GZ22_08405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GZ22_08410	COG0105	UTP biosynthetic process
GZ22_08415	COG0142	geranyltranstransferase activity
GZ22_08420	COG2226	methyltransferase
GZ22_08430	COG0776	regulation of translation
GZ22_08435	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GZ22_08450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZ22_08455	COG1160	GTP binding
GZ22_08465	COG0539	negative regulation of cytoplasmic translation
GZ22_08475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GZ22_08485	COG2959	enzyme of heme biosynthesis
GZ22_08490	COG3773	Cell wall hydrolase
GZ22_08490	COG3409	Peptidoglycan-binding domain 1 protein
GZ22_08495	COG2339	peptidase activity
GZ22_08505	COG0492	ferredoxin-NADP+ reductase activity
GZ22_08510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GZ22_08515	COG4862	establishment of competence for transformation
GZ22_08535	COG1141	Ferredoxin
GZ22_08550	COG5002	protein histidine kinase activity
GZ22_08555	COG0745	RESPONSE REGULATOR receiver
GZ22_08560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZ22_08565	COG1333	cytochrome c biogenesis protein
GZ22_08570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZ22_08575	COG1187	pseudouridine synthase activity
GZ22_08580	COG0700	Nucleoside recognition
GZ22_08585	COG2715	membrane protein required for spore maturation
GZ22_08590	COG1686	Belongs to the peptidase S11 family
GZ22_08600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GZ22_08605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GZ22_08625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZ22_08630	COG0019	diaminopimelate decarboxylase activity
GZ22_08635	COG0697	spore germination
GZ22_08650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZ22_08675	COG2172	sigma factor antagonist activity
GZ22_08685	COG1686	Belongs to the peptidase S11 family
GZ22_08700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GZ22_08705	COG4974	Belongs to the 'phage' integrase family
GZ22_08720	COG1300	Membrane
GZ22_08725	COG0494	nUDIX hydrolase
GZ22_08730	COG0667	Aldo Keto reductase
GZ22_08740	COG0300	oxidoreductase activity
GZ22_08745	COG4187	Peptidase family M20/M25/M40
GZ22_08750	COG0584	glycerophosphoryl diester phosphodiesterase
GZ22_08755	COG1902	pentaerythritol trinitrate reductase activity
GZ22_08760	COG1234	tRNA 3'-trailer cleavage
GZ22_08765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZ22_08770	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZ22_08780	COG1376	ErfK ybiS ycfS ynhG family protein
GZ22_08785	COG4129	membrane
GZ22_08795	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ22_08800	COG0022	dehydrogenase e1 component
GZ22_08805	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GZ22_08810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZ22_08825	COG0280	phosphate acetyltransferase
GZ22_08830	COG3290	protein histidine kinase activity
GZ22_08830	COG3829	transcription factor binding
GZ22_08835	COG0527	aspartate kinase activity
GZ22_08840	COG2160	L-arabinose isomerase activity
GZ22_08850	COG1879	ABC-type sugar transport system periplasmic component
GZ22_08855	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZ22_08860	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZ22_08865	COG1129	ABC transporter
GZ22_08870	COG2207	Transcriptional regulator
GZ22_08870	COG4753	response regulator
GZ22_08885	COG1349	DNA-binding transcription factor activity
GZ22_08890	COG4806	L-rhamnose isomerase
GZ22_08895	COG3254	rhamnose metabolic process
GZ22_08900	COG1070	Carbohydrate kinase
GZ22_08905	COG3347	Dehydrogenase
GZ22_08905	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_08910	COG2814	Major facilitator Superfamily
GZ22_08920	COG0745	RESPONSE REGULATOR receiver
GZ22_08925	COG0750	zinc metalloprotease
GZ22_08930	COG0497	DNA recombination
GZ22_08935	COG1438	arginine binding
GZ22_08940	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GZ22_08945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GZ22_08950	COG0142	geranyltranstransferase activity
GZ22_08955	COG1722	exodeoxyribonuclease VII activity
GZ22_08960	COG1570	exodeoxyribonuclease VII activity
GZ22_08965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GZ22_08970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZ22_08975	COG1302	Protein conserved in bacteria
GZ22_08980	COG0439	Biotin carboxylase
GZ22_08985	COG0511	ligase activity, forming carbon-carbon bonds
GZ22_08990	COG1132	(ABC) transporter
GZ22_08995	COG1132	(ABC) transporter
GZ22_09035	COG3854	ATPases associated with a variety of cellular activities
GZ22_09040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GZ22_09045	COG0006	proline dipeptidase activity
GZ22_09060	COG3872	metal-dependent enzyme
GZ22_09070	COG1752	Esterase of the alpha-beta hydrolase superfamily
GZ22_09075	COG1321	iron dependent repressor
GZ22_09080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZ22_09085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GZ22_09090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GZ22_09095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GZ22_09100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZ22_09120	COG1459	type II secretion system
GZ22_09125	COG4537	Required for transformation and DNA binding
GZ22_09155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZ22_09165	COG1368	sulfuric ester hydrolase activity
GZ22_09170	COG1940	carbohydrate kinase activity
GZ22_09180	COG1363	Peptidase, m42
GZ22_09190	COG0705	Rhomboid family
GZ22_09190	COG0457	Tetratricopeptide repeat
GZ22_09200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GZ22_09220	COG0704	Plays a role in the regulation of phosphate uptake
GZ22_09225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZ22_09230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZ22_09235	COG0581	inorganic phosphate transmembrane transporter activity
GZ22_09240	COG0573	inorganic phosphate transmembrane transporter activity
GZ22_09245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GZ22_09255	COG0477	Major facilitator Superfamily
GZ22_09260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GZ22_09295	COG1283	sodium-dependent phosphate transmembrane transporter activity
GZ22_09305	COG1388	LysM domain
GZ22_09310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GZ22_09325	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GZ22_09330	COG0513	Belongs to the DEAD box helicase family
GZ22_09335	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GZ22_09340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GZ22_09345	COG2384	SAM-dependent methyltransferase
GZ22_09350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZ22_09355	COG0358	DNA primase activity
GZ22_09360	COG1671	Belongs to the UPF0178 family
GZ22_09370	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GZ22_09375	COG0517	IMP dehydrogenase activity
GZ22_09380	COG0751	glycine-tRNA ligase activity
GZ22_09385	COG0752	glycyl-tRNA synthetase alpha subunit
GZ22_09390	COG1381	Involved in DNA repair and RecF pathway recombination
GZ22_09400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GZ22_09410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GZ22_09420	COG1702	phosphate starvation-inducible protein PhoH
GZ22_09440	COG4864	UPF0365 protein
GZ22_09450	COG1610	YqeY-like protein
GZ22_09460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GZ22_09465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZ22_09470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GZ22_09475	COG2264	protein methyltransferase activity
GZ22_09480	COG0484	heat shock protein binding
GZ22_09495	COG1420	regulation of RNA biosynthetic process
GZ22_09500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GZ22_09505	COG0481	GTPase activity
GZ22_09520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GZ22_09525	COG0268	Binds directly to 16S ribosomal RNA
GZ22_09530	COG1466	dna polymerase III delta subunit
GZ22_09535	COG2333	competence protein COMEC
GZ22_09535	COG0658	competence protein
GZ22_09540	COG2131	deaminase
GZ22_09545	COG1555	photosystem II stabilization
GZ22_09545	COG1596	polysaccharide export
GZ22_09550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GZ22_09555	COG2226	methyltransferase
GZ22_09560	COG0799	negative regulation of ribosome biogenesis
GZ22_09565	COG1713	HD superfamily hydrolase involved in NAD metabolism
GZ22_09570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GZ22_09575	COG1534	Rna-binding protein
GZ22_09580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GZ22_09585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GZ22_09590	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GZ22_09600	COG2111	Na H antiporter
GZ22_09600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GZ22_09605	COG1006	Multisubunit Na H antiporter MnhC subunit
GZ22_09610	COG0651	ATP synthesis coupled electron transport
GZ22_09615	COG1863	multisubunit Na H antiporter MnhE subunit
GZ22_09620	COG2212	antiporter activity
GZ22_09625	COG1320	monovalent cation:proton antiporter activity
GZ22_09630	COG1191	sigma factor activity
GZ22_09645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GZ22_09660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZ22_09675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GZ22_09680	COG3906	Belongs to the UPF0473 family
GZ22_09685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GZ22_09690	COG4472	Bacterial protein of unknown function (DUF965)
GZ22_09710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GZ22_09720	COG0482	sulfurtransferase activity
GZ22_09725	COG1104	cysteine desulfurase activity
GZ22_09730	COG1959	2 iron, 2 sulfur cluster binding
GZ22_09735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GZ22_09745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GZ22_09750	COG0124	histidyl-tRNA synthetase
GZ22_09760	COG1490	D-aminoacyl-tRNA deacylase activity
GZ22_09765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GZ22_09770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZ22_09775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GZ22_09775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GZ22_09785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZ22_09785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZ22_09795	COG2244	polysaccharide biosynthetic process
GZ22_09800	COG2323	membrane
GZ22_09810	COG1862	Preprotein translocase
GZ22_09820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GZ22_09830	COG2255	four-way junction helicase activity
GZ22_09835	COG0632	four-way junction helicase activity
GZ22_09855	COG0077	Prephenate dehydratase
GZ22_09860	COG4492	Belongs to the UPF0735 family
GZ22_09865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GZ22_09870	COG3290	protein histidine kinase activity
GZ22_09875	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GZ22_09880	COG2868	ribosomal protein
GZ22_09885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GZ22_09890	COG1530	ribonuclease E activity
GZ22_09895	COG1994	Peptidase M50
GZ22_09910	COG2860	membrane
GZ22_09915	COG2894	cell division
GZ22_09920	COG0850	regulation of cytokinetic process
GZ22_09930	COG1792	Involved in formation and maintenance of cell shape
GZ22_09935	COG1077	Cell shape determining protein MreB Mrl
GZ22_09940	COG2003	Belongs to the UPF0758 family
GZ22_09950	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GZ22_09960	COG3706	GGDEF domain
GZ22_09965	COG0285	dihydrofolate synthase activity
GZ22_09970	COG0189	ligase activity
GZ22_09975	COG0189	ligase activity
GZ22_09985	COG1119	ATPase activity
GZ22_09995	COG2197	response regulator
GZ22_10000	COG4585	Histidine kinase
GZ22_10040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GZ22_10050	COG2076	Multidrug Resistance protein
GZ22_10055	COG2076	Multidrug Resistance protein
GZ22_10070	COG2226	methyltransferase
GZ22_10100	COG1064	alcohol dehydrogenase
GZ22_10105	COG0789	Transcriptional regulator
GZ22_10110	COG2207	Transcriptional regulator
GZ22_10115	COG0667	Aldo Keto reductase
GZ22_10125	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_10135	COG0738	Major facilitator superfamily
GZ22_10145	COG0697	spore germination
GZ22_10150	COG1917	Cupin 2, conserved barrel domain protein
GZ22_10150	COG2207	Transcriptional regulator
GZ22_10155	COG1120	ATPase activity
GZ22_10160	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_10165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_10175	COG1113	amino acid transport
GZ22_10195	COG0525	valine-tRNA ligase activity
GZ22_10210	COG1388	LysM domain
GZ22_10210	COG1388	LysM domain
GZ22_10220	COG0113	porphobilinogen synthase activity
GZ22_10230	COG0181	hydroxymethylbilane synthase activity
GZ22_10235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZ22_10250	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GZ22_10255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GZ22_10260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GZ22_10265	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZ22_10295	COG3773	Cell wall hydrolase
GZ22_10310	COG2207	Transcriptional regulator
GZ22_10310	COG4753	response regulator
GZ22_10325	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_10330	COG0673	inositol 2-dehydrogenase activity
GZ22_10335	COG5578	integral membrane protein
GZ22_10340	COG0395	ABC-type sugar transport system, permease component
GZ22_10345	COG1175	transmembrane transport
GZ22_10350	COG1653	transport
GZ22_10355	COG2814	Major facilitator Superfamily
GZ22_10360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GZ22_10370	COG2814	Major facilitator Superfamily
GZ22_10375	COG1609	Transcriptional regulator
GZ22_10395	COG0622	Phosphoesterase
GZ22_10400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GZ22_10410	COG5401	PFAM Sporulation and spore germination
GZ22_10415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GZ22_10420	COG1846	Transcriptional regulator
GZ22_10425	COG3263	regulation of cellular component size
GZ22_10460	COG2197	response regulator
GZ22_10475	COG1247	-acetyltransferase
GZ22_10500	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_10510	COG1525	nuclease
GZ22_10520	COG2318	DinB family
GZ22_10540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZ22_10550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GZ22_10555	COG1053	succinate dehydrogenase
GZ22_10560	COG2009	succinate dehydrogenase
GZ22_10565	COG1719	4-vinyl reductase, 4VR
GZ22_10590	COG0322	excinuclease ABC activity
GZ22_10595	COG3118	belongs to the thioredoxin family
GZ22_10600	COG3766	membrane
GZ22_10605	COG1193	negative regulation of DNA recombination
GZ22_10610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZ22_10610	COG1796	DNA polymerase
GZ22_10615	COG1286	toxin biosynthetic process
GZ22_10620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GZ22_10625	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZ22_10630	COG1403	HNH endonuclease
GZ22_10640	COG0072	phenylalanine-tRNA ligase activity
GZ22_10640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZ22_10645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GZ22_10650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZ22_10660	COG0741	lytic transglycosylase activity
GZ22_10665	COG1363	Peptidase, m42
GZ22_10680	COG0398	Pfam SNARE associated Golgi protein
GZ22_10685	COG3326	Membrane
GZ22_10690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GZ22_10695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GZ22_10700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GZ22_10715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZ22_10725	COG1484	DNA-dependent DNA replication
GZ22_10730	COG3611	Membrane attachment protein
GZ22_10735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GZ22_10740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZ22_10745	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GZ22_10750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GZ22_10755	COG0237	dephospho-CoA kinase activity
GZ22_10760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GZ22_10765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZ22_10765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZ22_10770	COG5002	protein histidine kinase activity
GZ22_10775	COG0745	RESPONSE REGULATOR receiver
GZ22_10780	COG0039	L-malate dehydrogenase activity
GZ22_10785	COG0538	isocitrate dehydrogenase activity
GZ22_10790	COG0372	Belongs to the citrate synthase family
GZ22_10800	COG0628	permease
GZ22_10805	COG3030	protein affecting phage T7 exclusion by the F plasmid
GZ22_10820	COG0825	malonyl-CoA metabolic process
GZ22_10825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GZ22_10830	COG0281	malic enzyme
GZ22_10835	COG0587	DNA-directed DNA polymerase activity
GZ22_10850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GZ22_10855	COG4109	DRTGG domain
GZ22_10860	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZ22_10865	COG0006	proline dipeptidase activity
GZ22_10875	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GZ22_10880	COG0827	DNA restriction-modification system
GZ22_10885	COG3493	citrate carrier protein
GZ22_10895	COG4565	transcriptional regulatory protein
GZ22_10900	COG3290	protein histidine kinase activity
GZ22_10905	COG3874	Sporulation protein YtfJ
GZ22_10920	COG0301	tRNA thio-modification
GZ22_10925	COG1104	cysteine desulfurase activity
GZ22_10930	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GZ22_10935	COG1309	transcriptional regulator
GZ22_10940	COG1956	GAF domain-containing protein
GZ22_10950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GZ22_10975	COG1063	alcohol dehydrogenase
GZ22_10985	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GZ22_10990	COG1063	alcohol dehydrogenase
GZ22_10995	COG3775	system Galactitol-specific IIC component
GZ22_11000	COG3414	Phosphotransferase system galactitol-specific IIB component
GZ22_11010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_11020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GZ22_11035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GZ22_11035	COG1605	Chorismate mutase
GZ22_11050	COG3118	belongs to the thioredoxin family
GZ22_11065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GZ22_11070	COG1674	ftsk spoiiie
GZ22_11075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZ22_11080	COG4848	Belongs to the UPF0354 family
GZ22_11085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZ22_11090	COG0840	transmembrane signaling receptor activity
GZ22_11095	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GZ22_11100	COG1363	Peptidase, m42
GZ22_11110	COG1486	melibiose metabolic process
GZ22_11115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GZ22_11125	COG0510	thiamine kinase activity
GZ22_11145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZ22_11150	COG1349	DNA-binding transcription factor activity
GZ22_11155	COG1187	pseudouridine synthase activity
GZ22_11160	COG2244	polysaccharide biosynthetic process
GZ22_11165	COG2081	HI0933 family
GZ22_11190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GZ22_11195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZ22_11200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZ22_11205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GZ22_11210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GZ22_11215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZ22_11220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GZ22_11225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZ22_11235	COG0037	tRNA processing
GZ22_11240	COG0515	serine threonine protein kinase
GZ22_11245	COG2304	oxidoreductase activity
GZ22_11250	COG2208	phosphoserine phosphatase activity
GZ22_11265	COG0406	alpha-ribazole phosphatase activity
GZ22_11275	COG1098	S1 RNA binding domain
GZ22_11295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GZ22_11305	COG2244	polysaccharide biosynthetic process
GZ22_11320	COG2002	toxin-antitoxin pair type II binding
GZ22_11325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GZ22_11345	COG1131	(ABC) transporter
GZ22_11365	COG1595	DNA-templated transcription, initiation
GZ22_11370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GZ22_11375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZ22_11390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZ22_11395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GZ22_11405	COG4466	Protein conserved in bacteria
GZ22_11415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GZ22_11425	COG0084	hydrolase, TatD family'
GZ22_11435	COG2002	toxin-antitoxin pair type II binding
GZ22_11440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GZ22_11445	COG2827	Endonuclease containing a URI domain
GZ22_11450	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GZ22_11455	COG4467	Involved in initiation control of chromosome replication
GZ22_11460	COG1774	PSP1 C-terminal conserved region
GZ22_11465	COG0470	DNA polymerase III
GZ22_11470	COG1728	Protein conserved in bacteria
GZ22_11475	COG3870	Protein conserved in bacteria
GZ22_11480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZ22_11485	COG1982	Orn Lys Arg decarboxylase major
GZ22_11555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GZ22_11560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GZ22_11565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GZ22_11570	COG0590	tRNA wobble adenosine to inosine editing
GZ22_11575	COG1335	isochorismatase
GZ22_11580	COG3858	chitin binding
GZ22_11580	COG1388	LysM domain
GZ22_11590	COG0693	protein deglycase activity
GZ22_11595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZ22_11600	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_11615	COG0697	spore germination
GZ22_11635	COG1428	Deoxynucleoside kinase
GZ22_11640	COG1428	Deoxynucleoside kinase
GZ22_11660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GZ22_11670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GZ22_11695	COG0517	IMP dehydrogenase activity
GZ22_11695	COG0516	GMP reductase activity
GZ22_11710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZ22_11715	COG0187	DNA topoisomerase II activity
GZ22_11725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZ22_11730	COG2501	S4 domain
GZ22_11735	COG0592	DNA-directed DNA polymerase activity
GZ22_11740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GZ22_11745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GZ22_11750	COG0594	ribonuclease P activity
GZ22_11755	COG0706	membrane insertase activity
GZ22_11760	COG1847	R3H domain protein
GZ22_11765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GZ22_11770	COG0445	tRNA wobble uridine modification
GZ22_11775	COG0357	Ribosomal RNA small subunit methyltransferase G
GZ22_11780	COG1475	DNA binding
GZ22_11785	COG1192	Involved in chromosome partitioning
GZ22_11790	COG1475	DNA binding
GZ22_11800	COG3949	Membrane
GZ22_11805	COG0668	transmembrane transport
GZ22_11810	COG4481	Protein conserved in bacteria
GZ22_11815	COG0012	GTP binding
GZ22_11820	COG0360	Binds together with S18 to 16S ribosomal RNA
GZ22_11825	COG0629	single-stranded DNA binding
GZ22_11830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GZ22_11835	COG2814	Major facilitator Superfamily
GZ22_11840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GZ22_11850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZ22_11855	COG0531	amino acid
GZ22_11870	COG4241	membrane
GZ22_11875	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GZ22_11880	COG0359	binds to the 23S rRNA
GZ22_11885	COG0305	Participates in initiation and elongation during chromosome replication
GZ22_11890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GZ22_11895	COG0745	RESPONSE REGULATOR receiver
GZ22_11900	COG5002	protein histidine kinase activity
GZ22_11905	COG4863	YycH protein
GZ22_11910	COG4853	Protein conserved in bacteria
GZ22_11915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GZ22_11920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZ22_11925	COG1511	domain protein
GZ22_11930	COG1309	transcriptional regulator
GZ22_11935	COG2202	Pas domain
GZ22_11935	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_11940	COG1482	cell wall glycoprotein biosynthetic process
GZ22_11945	COG0768	penicillin binding
GZ22_11955	COG0833	amino acid
GZ22_11960	COG0154	amidase activity
GZ22_11970	COG1113	amino acid transport
GZ22_11975	COG1136	(ABC) transporter
GZ22_11980	COG0577	efflux transmembrane transporter activity
GZ22_11985	COG0745	RESPONSE REGULATOR receiver
GZ22_11990	COG5002	protein histidine kinase activity
GZ22_11995	COG4412	M6 family metalloprotease domain protein
GZ22_11995	COG3291	Pkd domain containing protein
GZ22_12025	COG1609	Transcriptional regulator
GZ22_12030	COG1486	melibiose metabolic process
GZ22_12035	COG1609	Transcriptional regulator
GZ22_12040	COG0561	phosphatase activity
GZ22_12050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZ22_12055	COG0534	Mate efflux family protein
GZ22_12060	COG0772	Belongs to the SEDS family
GZ22_12080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GZ22_12085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GZ22_12090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZ22_12095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_12100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_12105	COG2819	hydrolase of the alpha beta superfamily
GZ22_12155	COG1174	glycine betaine transport
GZ22_12160	COG1732	Glycine betaine
GZ22_12165	COG1174	glycine betaine transport
GZ22_12170	COG1125	glycine betaine transport
GZ22_12170	COG0517	IMP dehydrogenase activity
GZ22_12210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZ22_12225	COG0640	Transcriptional regulator
GZ22_12230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GZ22_12235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZ22_12245	COG2723	6-phospho-beta-galactosidase activity
GZ22_12250	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZ22_12270	COG0745	RESPONSE REGULATOR receiver
GZ22_12275	COG2205	protein histidine kinase activity
GZ22_12280	COG1136	(ABC) transporter
GZ22_12285	COG0577	efflux transmembrane transporter activity
GZ22_12290	COG1388	LysM domain
GZ22_12300	COG0601	transmembrane transport
GZ22_12310	COG0444	Belongs to the ABC transporter superfamily
GZ22_12315	COG4608	Belongs to the ABC transporter superfamily
GZ22_12350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_12355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_12375	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_12380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZ22_12385	COG0586	Pfam SNARE associated Golgi protein
GZ22_12395	COG3619	membrane
GZ22_12400	COG1316	TRANSCRIPTIONal
GZ22_12415	COG1309	transcriptional regulator
GZ22_12430	COG3011	Protein conserved in bacteria
GZ22_12435	COG3420	alginic acid biosynthetic process
GZ22_12460	COG1280	lysine exporter protein (LysE YggA)
GZ22_12465	COG4335	DNA alkylation repair
GZ22_12480	COG2207	Transcriptional regulator
GZ22_12495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GZ22_12505	COG0475	glutathione-regulated potassium exporter activity
GZ22_12515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_12520	COG2223	nitrite transmembrane transporter activity
GZ22_12525	COG3279	Response regulator of the LytR AlgR family
GZ22_12530	COG3275	phosphorelay sensor kinase activity
GZ22_12535	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GZ22_12540	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_12550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZ22_12555	COG1414	Transcriptional regulator
GZ22_12560	COG0800	Aldolase
GZ22_12585	COG4221	oxidoreductase activity
GZ22_12640	COG1051	belongs to the nudix hydrolase family
GZ22_12645	COG2318	DinB family
GZ22_12650	COG0716	FMN binding
GZ22_12655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZ22_12660	COG3711	transcriptional antiterminator
GZ22_12685	COG2076	Multidrug Resistance protein
GZ22_12690	COG2076	Multidrug Resistance protein
GZ22_12695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_12700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_12705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZ22_12720	COG0473	3-isopropylmalate dehydrogenase activity
GZ22_12730	COG1349	DNA-binding transcription factor activity
GZ22_12735	COG3395	kinase activity
GZ22_12740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GZ22_12755	COG0772	Belongs to the SEDS family
GZ22_12765	COG1522	sequence-specific DNA binding
GZ22_12770	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZ22_12775	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_12805	COG5386	Cell surface protein
GZ22_12820	COG1120	ATPase activity
GZ22_12825	COG4509	Sortase family
GZ22_12835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_12840	COG1120	ATPase activity
GZ22_12860	COG0477	Major facilitator Superfamily
GZ22_12870	COG2030	dehydratase
GZ22_12925	COG0778	Nitroreductase
GZ22_12930	COG0346	lactoylglutathione lyase activity
GZ22_12935	COG0346	lactoylglutathione lyase activity
GZ22_12940	COG0400	carboxylic ester hydrolase activity
GZ22_12945	COG0655	NAD(P)H dehydrogenase (quinone) activity
GZ22_12955	COG1918	ferrous iron import across plasma membrane
GZ22_12955	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GZ22_12960	COG0673	inositol 2-dehydrogenase activity
GZ22_12970	COG0457	Tetratricopeptide repeat
GZ22_13005	COG3715	PTS system
GZ22_13010	COG3716	PTS system mannose fructose sorbose family IID component
GZ22_13015	COG0673	inositol 2-dehydrogenase activity
GZ22_13030	COG1263	PTS System
GZ22_13030	COG2190	(PTS) system
GZ22_13030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_13035	COG2723	6-phospho-beta-galactosidase activity
GZ22_13040	COG3711	transcriptional antiterminator
GZ22_13055	COG1879	ABC-type sugar transport system periplasmic component
GZ22_13060	COG1129	ABC transporter
GZ22_13065	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZ22_13080	COG3395	kinase activity
GZ22_13105	COG4585	Histidine kinase
GZ22_13110	COG2197	response regulator
GZ22_13120	COG3142	Participates in the control of copper homeostasis
GZ22_13130	COG0733	neurotransmitter:sodium symporter activity
GZ22_13135	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GZ22_13140	COG1506	peptidase
GZ22_13140	COG0823	Involved in the tonB-independent uptake of proteins
GZ22_13140	COG4946	Tricorn protease homolog
GZ22_13145	COG1228	amidohydrolase
GZ22_13150	COG0601	transmembrane transport
GZ22_13155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZ22_13165	COG4608	Belongs to the ABC transporter superfamily
GZ22_13170	COG4166	transmembrane transport
GZ22_13185	COG1695	Transcriptional regulator
GZ22_13210	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GZ22_13225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GZ22_13260	COG0385	Bile acid
GZ22_13275	COG5002	protein histidine kinase activity
GZ22_13280	COG2226	methyltransferase
GZ22_13285	COG5504	Zn-dependent protease
GZ22_13295	COG1113	amino acid transport
GZ22_13305	COG5444	nuclease activity
GZ22_13315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZ22_13335	COG0840	transmembrane signaling receptor activity
GZ22_13335	COG3290	protein histidine kinase activity
GZ22_13340	COG0745	RESPONSE REGULATOR receiver
GZ22_13350	COG1131	(ABC) transporter
GZ22_13360	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GZ22_13365	COG0402	S-adenosylhomocysteine deaminase activity
GZ22_13440	COG0670	Belongs to the BI1 family
GZ22_13450	COG3588	fructose-bisphosphate aldolase
GZ22_13455	COG2972	Histidine kinase
GZ22_13460	COG2207	Transcriptional regulator
GZ22_13460	COG4753	response regulator
GZ22_13465	COG2182	Extracellular solute-binding protein
GZ22_13470	COG1621	beta-fructofuranosidase activity
GZ22_13475	COG1621	beta-fructofuranosidase activity
GZ22_13480	COG1914	H( )-stimulated, divalent metal cation uptake system
GZ22_13485	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GZ22_13490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GZ22_13495	COG1984	allophanate hydrolase subunit 2
GZ22_13505	COG3634	alkyl hydroperoxide reductase activity
GZ22_13510	COG0450	alkyl hydroperoxide reductase
GZ22_13515	COG0840	transmembrane signaling receptor activity
GZ22_13520	COG1785	Belongs to the alkaline phosphatase family
GZ22_13525	COG3858	chitin binding
GZ22_13535	COG0697	spore germination
GZ22_13545	COG4509	Sortase family
GZ22_13560	COG1917	Cupin 2, conserved barrel domain protein
GZ22_13560	COG2207	Transcriptional regulator
GZ22_13570	COG3546	catalase activity
GZ22_13580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GZ22_13590	COG2323	membrane
GZ22_13605	COG5039	Polysaccharide pyruvyl transferase
GZ22_13610	COG1288	antiporter activity
GZ22_13615	COG1473	amidohydrolase
GZ22_13620	COG0492	ferredoxin-NADP+ reductase activity
GZ22_13625	COG1959	2 iron, 2 sulfur cluster binding
GZ22_13635	COG0583	DNA-binding transcription factor activity
GZ22_13640	COG0842	Transport permease protein
GZ22_13640	COG1511	domain protein
GZ22_13655	COG2186	Transcriptional regulator
GZ22_13660	COG0247	lactate metabolic process
GZ22_13665	COG1139	Iron-sulfur cluster binding protein
GZ22_13670	COG1556	Lactate utilization protein
GZ22_13695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZ22_13700	COG2011	ABC-type metal ion transport system permease component
GZ22_13720	COG1279	arginine transmembrane transporter activity
GZ22_13730	COG1114	Component of the transport system for branched-chain amino acids
GZ22_13750	COG0457	Tetratricopeptide repeat
GZ22_13765	COG0110	maltose O-acetyltransferase activity
GZ22_13790	COG2017	converts alpha-aldose to the beta-anomer
GZ22_13800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GZ22_13805	COG1609	Transcriptional regulator
GZ22_13810	COG2182	Extracellular solute-binding protein
GZ22_13815	COG1175	transmembrane transport
GZ22_13820	COG3833	ABC-type maltose transport systems, permease component
GZ22_13825	COG1874	Beta-galactosidase
GZ22_13830	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_13845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZ22_13850	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_13855	COG2271	Major facilitator Superfamily
GZ22_13860	COG4948	Mandelate Racemase Muconate Lactonizing
GZ22_13865	COG2186	Transcriptional regulator
GZ22_13885	COG3069	C4-dicarboxylate transmembrane transporter activity
GZ22_13890	COG2190	(PTS) system
GZ22_13890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_13890	COG1263	PTS System
GZ22_13895	COG2723	6-phospho-beta-galactosidase activity
GZ22_13910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GZ22_13915	COG1177	transmembrane transport
GZ22_13920	COG1176	ABC-type spermidine putrescine transport system, permease component I
GZ22_13960	COG0463	Glycosyl transferase, family 2
GZ22_13960	COG1216	Glycosyl transferase, family 2
GZ22_13965	COG0438	transferase activity, transferring glycosyl groups
GZ22_13975	COG1086	Polysaccharide biosynthesis protein
GZ22_13995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZ22_14015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GZ22_14025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZ22_14025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZ22_14035	COG0561	phosphatase activity
GZ22_14050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZ22_14055	COG2514	catechol 2,3-dioxygenase activity
GZ22_14080	COG5001	Diguanylate cyclase
GZ22_14080	COG4251	negative regulation of phosphorylation
GZ22_14080	COG3706	GGDEF domain
GZ22_14080	COG2203	Gaf domain
GZ22_14125	COG2721	sulfolactate sulfo-lyase activity
GZ22_14130	COG0477	Major facilitator Superfamily
GZ22_14135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZ22_14140	COG0765	amino acid transport
GZ22_14145	COG1126	abc transporter atp-binding protein
GZ22_14160	COG1063	alcohol dehydrogenase
GZ22_14165	COG0667	Aldo Keto reductase
GZ22_14175	COG1309	transcriptional regulator
GZ22_14180	COG1073	alpha beta
GZ22_14185	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_14190	COG0400	carboxylic ester hydrolase activity
GZ22_14195	COG1846	Transcriptional regulator
GZ22_14200	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZ22_14205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZ22_14215	COG2211	Major facilitator Superfamily
GZ22_14230	COG0640	Transcriptional regulator
GZ22_14235	COG0659	secondary active sulfate transmembrane transporter activity
GZ22_14260	COG1842	Phage shock protein A
GZ22_14270	COG3766	membrane
GZ22_14275	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GZ22_14280	COG1522	sequence-specific DNA binding
GZ22_14305	COG1742	UPF0060 membrane protein
GZ22_14315	COG1174	glycine betaine transport
GZ22_14330	COG1979	alcohol dehydrogenase
GZ22_14340	COG0385	Bile acid
GZ22_14355	COG1653	transport
GZ22_14365	COG1175	transmembrane transport
GZ22_14370	COG3842	ATPase activity
GZ22_14390	COG0789	Transcriptional regulator
GZ22_14400	COG1464	Belongs to the NlpA lipoprotein family
GZ22_14405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZ22_14410	COG2011	ABC-type metal ion transport system permease component
GZ22_14415	COG0306	phosphate transporter
GZ22_14420	COG1392	Phosphate transport regulator
GZ22_14425	COG4841	protein insertion into membrane
GZ22_14455	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GZ22_14460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZ22_14465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GZ22_14480	COG3842	ATPase activity
GZ22_14485	COG2318	DinB family
GZ22_14490	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_14505	COG0246	Mannitol dehydrogenase
GZ22_14510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_14515	COG3711	transcriptional antiterminator
GZ22_14525	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GZ22_14530	COG1360	Flagellar Motor Protein
GZ22_14540	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZ22_14550	COG0179	Fumarylacetoacetate (FAA) hydrolase
GZ22_14565	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GZ22_14570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GZ22_14575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZ22_14580	COG0788	formyltetrahydrofolate deformylase activity
GZ22_14585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZ22_14590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GZ22_14600	COG2130	NADP-dependent
GZ22_14605	COG4876	unkown
GZ22_14615	COG0251	oxidation-reduction process
GZ22_14620	COG2814	Major facilitator Superfamily
GZ22_14625	COG3973	AAA domain
GZ22_14630	COG0471	metal ion transport
GZ22_14635	COG2084	Dehydrogenase
GZ22_14640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_14650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_14660	COG2309	aminopeptidase activity
GZ22_14685	COG0346	lactoylglutathione lyase activity
GZ22_14690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GZ22_14695	COG2056	Na+-H+ antiporter family
GZ22_14710	COG1757	Na H antiporter
GZ22_14715	COG1027	Aspartate ammonia-lyase
GZ22_14720	COG0252	asparaginase activity
GZ22_14725	COG1396	sequence-specific DNA binding
GZ22_14735	COG0778	Nitroreductase
GZ22_14745	COG3639	organic phosphonate transmembrane transporter activity
GZ22_14760	COG0737	Belongs to the 5'-nucleotidase family
GZ22_14765	COG1388	LysM domain
GZ22_14765	COG3584	3D domain protein
GZ22_14780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GZ22_14785	COG0512	Glutamine amidotransferase of anthranilate synthase
GZ22_14785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GZ22_14790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GZ22_14795	COG0134	indole-3-glycerol-phosphate synthase activity
GZ22_14800	COG0135	phosphoribosylanthranilate isomerase activity
GZ22_14810	COG0159	tryptophan synthase activity
GZ22_14815	COG4152	abc transporter atp-binding protein
GZ22_14820	COG1668	transmembrane transport
GZ22_14840	COG0488	(ABC) transporter
GZ22_14855	COG2124	cytochrome p450
GZ22_14900	COG2197	response regulator
GZ22_14910	COG2755	lipolytic protein G-D-S-L family
GZ22_14925	COG2962	Rard protein
GZ22_14930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZ22_14935	COG1607	acyl-coa hydrolase
GZ22_14940	COG0840	transmembrane signaling receptor activity
GZ22_14950	COG0351	phosphomethylpyrimidine kinase
GZ22_14955	COG0488	(ABC) transporter
GZ22_14965	COG0514	ATP-dependent DNA helicase (RecQ)
GZ22_14970	COG1253	flavin adenine dinucleotide binding
GZ22_14985	COG1605	Chorismate mutase
GZ22_14985	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GZ22_14990	COG2814	Major facilitator Superfamily
GZ22_15000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZ22_15005	COG0861	Integral membrane protein TerC family
GZ22_15010	COG1764	response to oxidative stress
GZ22_15020	COG3443	Belongs to the bacterial solute-binding protein 9 family
GZ22_15020	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZ22_15030	COG3285	dna ligase
GZ22_15030	COG1793	dna ligase
GZ22_15035	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GZ22_15075	COG2363	Small membrane protein
GZ22_15090	COG0280	phosphate acetyltransferase
GZ22_15095	COG2202	Pas domain
GZ22_15095	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_15100	COG0095	Lipoate-protein ligase
GZ22_15105	COG1078	dGTPase activity
GZ22_15110	COG3465	dGTPase activity
GZ22_15130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZ22_15150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZ22_15160	COG3343	RNA polymerase activity
GZ22_15165	COG0504	CTP synthase activity
GZ22_15170	COG2204	response regulator
GZ22_15175	COG0191	fructose-bisphosphate aldolase activity
GZ22_15180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GZ22_15185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZ22_15190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GZ22_15195	COG0254	rRNA binding
GZ22_15200	COG1435	thymidine kinase activity
GZ22_15210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GZ22_15215	COG2890	protein-(glutamine-N5) methyltransferase activity
GZ22_15230	COG0009	L-threonylcarbamoyladenylate synthase
GZ22_15245	COG0698	ribose 5-phosphate isomerase
GZ22_15250	COG4475	Protein of unknown function (DUF436)
GZ22_15255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZ22_15260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GZ22_15265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GZ22_15270	COG1404	Belongs to the peptidase S8 family
GZ22_15280	COG0356	it plays a direct role in the translocation of protons across the membrane
GZ22_15290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GZ22_15295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZ22_15300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GZ22_15305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZ22_15310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GZ22_15315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GZ22_15320	COG4836	Membrane
GZ22_15335	COG2362	D-Aminopeptidase
GZ22_15340	COG0601	transmembrane transport
GZ22_15345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZ22_15350	COG0444	Belongs to the ABC transporter superfamily
GZ22_15355	COG4166	transmembrane transport
GZ22_15360	COG1619	proteins homologs of microcin C7 resistance protein MccF
GZ22_15365	COG4948	Mandelate Racemase Muconate Lactonizing
GZ22_15370	COG0791	NLP P60 protein
GZ22_15375	COG2385	sporulation resulting in formation of a cellular spore
GZ22_15380	COG0739	heme binding
GZ22_15390	COG1609	Transcriptional regulator
GZ22_15395	COG1077	Cell shape determining protein MreB Mrl
GZ22_15400	COG4786	Flagellar basal body rod
GZ22_15405	COG4786	Flagellar basal body rod
GZ22_15420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GZ22_15450	COG0438	transferase activity, transferring glycosyl groups
GZ22_15460	COG2002	toxin-antitoxin pair type II binding
GZ22_15465	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_15495	COG0728	peptidoglycan biosynthetic process
GZ22_15515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZ22_15525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GZ22_15535	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZ22_15570	COG1134	teichoic acid transport
GZ22_15575	COG1682	transport, permease protein
GZ22_15610	COG2851	Citrate transporter
GZ22_15625	COG1940	carbohydrate kinase activity
GZ22_15635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GZ22_15640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_15645	COG3386	PFAM SMP-30 Gluconolaconase
GZ22_15655	COG0457	Tetratricopeptide repeat
GZ22_15660	COG0534	Mate efflux family protein
GZ22_15680	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GZ22_15690	COG0791	NLP P60 protein
GZ22_15690	COG1388	LysM domain
GZ22_15695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GZ22_15700	COG3944	biosynthesis protein
GZ22_15705	COG0489	protein tyrosine kinase activity
GZ22_15710	COG4464	protein tyrosine phosphatase activity
GZ22_15715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GZ22_15725	COG0438	transferase activity, transferring glycosyl groups
GZ22_15730	COG0662	Cupin 2, conserved barrel domain protein
GZ22_15730	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GZ22_15750	COG4464	protein tyrosine phosphatase activity
GZ22_15760	COG1316	TRANSCRIPTIONal
GZ22_15790	COG1113	amino acid transport
GZ22_15795	COG1280	lysine exporter protein (LysE YggA)
GZ22_15805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GZ22_15820	COG2723	6-phospho-beta-galactosidase activity
GZ22_15830	COG0346	lactoylglutathione lyase activity
GZ22_15840	COG0248	Ppx GppA phosphatase
GZ22_15880	COG1215	transferase activity, transferring glycosyl groups
GZ22_15890	COG0506	proline dehydrogenase activity
GZ22_15895	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_15915	COG0523	cobalamin synthesis protein
GZ22_15920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZ22_15925	COG0523	cobalamin synthesis protein
GZ22_15935	COG0840	transmembrane signaling receptor activity
GZ22_15940	COG2508	Transcriptional regulator
GZ22_15955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZ22_15960	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZ22_15965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZ22_15970	COG2723	6-phospho-beta-galactosidase activity
GZ22_15975	COG2188	Transcriptional regulator
GZ22_15980	COG1737	Transcriptional regulator
GZ22_15985	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GZ22_16005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZ22_16015	COG4977	sequence-specific DNA binding
GZ22_16015	COG1917	Cupin 2, conserved barrel domain protein
GZ22_16085	COG1309	transcriptional regulator
GZ22_16090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZ22_16095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZ22_16100	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZ22_16105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_16105	COG3711	transcriptional antiterminator
GZ22_16125	COG1472	Belongs to the glycosyl hydrolase 3 family
GZ22_16130	COG1846	Transcriptional regulator
GZ22_16135	COG2409	Drug exporters of the RND superfamily
GZ22_16135	COG1033	growth of symbiont in host cell
GZ22_16150	COG2267	carboxylic ester hydrolase activity
GZ22_16170	COG1011	Hydrolase
GZ22_16175	COG0561	phosphatase activity
GZ22_16185	COG2059	Chromate
GZ22_16190	COG2059	Chromate
GZ22_16205	COG0205	6-phosphofructokinase activity
GZ22_16230	COG1082	Xylose isomerase domain protein TIM barrel
GZ22_16240	COG0559	Belongs to the binding-protein-dependent transport system permease family
GZ22_16260	COG1737	Transcriptional regulator
GZ22_16270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_16270	COG1263	PTS System
GZ22_16280	COG1301	dicarboxylic acid transport
GZ22_16290	COG2186	Transcriptional regulator
GZ22_16295	COG3764	Sortase (surface protein transpeptidase)
GZ22_16315	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GZ22_16320	COG0363	glucosamine-6-phosphate deaminase activity
GZ22_16325	COG1739	Uncharacterized protein family UPF0029
GZ22_16330	COG4585	Histidine kinase
GZ22_16340	COG1307	EDD domain protein, DegV family
GZ22_16345	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GZ22_16350	COG1040	competence protein
GZ22_16360	COG2747	anti-sigma28 factor FlgM
GZ22_16370	COG4786	Flagellar basal body rod
GZ22_16370	COG1256	bacterial-type flagellum assembly
GZ22_16375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZ22_16385	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GZ22_16390	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GZ22_16395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZ22_16400	COG0463	Glycosyl transferase, family 2
GZ22_16410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZ22_16415	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_16420	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_16425	COG1334	flagellar protein FlaG
GZ22_16430	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GZ22_16435	COG1516	flagellar protein fliS
GZ22_16445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GZ22_16455	COG0653	protein targeting
GZ22_16460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GZ22_16470	COG2884	Cell division ATP-binding protein ftsE
GZ22_16475	COG2177	Part of the ABC transporter FtsEX involved in
GZ22_16480	COG0739	heme binding
GZ22_16485	COG3409	Peptidoglycan-binding domain 1 protein
GZ22_16485	COG0793	Belongs to the peptidase S41A family
GZ22_16490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZ22_16505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZ22_16510	COG2190	(PTS) system
GZ22_16515	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GZ22_16520	COG0556	nucleotide-excision repair
GZ22_16525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZ22_16530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GZ22_16540	COG3595	metallopeptidase activity
GZ22_16545	COG1950	PFAM Membrane protein of
GZ22_16550	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GZ22_16555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GZ22_16560	COG0546	phosphoglycolate phosphatase activity
GZ22_16565	COG0110	maltose O-acetyltransferase activity
GZ22_16570	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GZ22_16580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GZ22_16585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GZ22_16590	COG0457	Tetratricopeptide repeat
GZ22_16595	COG0492	ferredoxin-NADP+ reductase activity
GZ22_16600	COG1051	belongs to the nudix hydrolase family
GZ22_16605	COG1660	Displays ATPase and GTPase activities
GZ22_16610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GZ22_16615	COG1481	regulation of sporulation
GZ22_16620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_16625	COG0616	signal peptide processing
GZ22_16630	COG1714	RDD family
GZ22_16635	COG0740	serine-type endopeptidase activity
GZ22_16640	COG3546	catalase activity
GZ22_16695	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_16700	COG0028	Belongs to the TPP enzyme family
GZ22_16705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GZ22_16710	COG2814	Major facilitator Superfamily
GZ22_16715	COG3546	catalase activity
GZ22_16730	COG0519	Catalyzes the synthesis of GMP from XMP
GZ22_16745	COG0347	Belongs to the P(II) protein family
GZ22_16750	COG0004	ammonium transporteR
GZ22_16755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GZ22_16785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZ22_16795	COG2204	response regulator
GZ22_16805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GZ22_16810	COG0534	Mate efflux family protein
GZ22_16820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GZ22_16825	COG0126	phosphoglycerate kinase activity
GZ22_16830	COG0149	triose-phosphate isomerase activity
GZ22_16835	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GZ22_16840	COG0148	phosphopyruvate hydratase activity
GZ22_16885	COG0300	oxidoreductase activity
GZ22_16895	COG1082	Xylose isomerase domain protein TIM barrel
GZ22_16900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZ22_16905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_16910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_16910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZ22_16910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZ22_16915	COG1105	Belongs to the carbohydrate kinase PfkB family
GZ22_16920	COG1349	DNA-binding transcription factor activity
GZ22_16925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZ22_16930	COG1647	Serine aminopeptidase, S33
GZ22_16935	COG0557	exoribonuclease II activity
GZ22_16945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GZ22_16950	COG0024	Methionine aminopeptidase
GZ22_16975	COG0753	catalase activity
GZ22_16980	COG3706	GGDEF domain
GZ22_16990	COG1413	lyase activity
GZ22_16995	COG0586	Pfam SNARE associated Golgi protein
GZ22_17000	COG1968	undecaprenyl-diphosphatase activity
GZ22_17020	COG5577	PFAM Coat F domain
GZ22_17035	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_17040	COG4605	iron ion homeostasis
GZ22_17045	COG4604	ABC transporter, ATP-binding protein
GZ22_17050	COG4607	ABC-type enterochelin transport system periplasmic component
GZ22_17055	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GZ22_17065	COG2814	Major facilitator Superfamily
GZ22_17080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZ22_17095	COG1960	acyl-CoA dehydrogenase activity
GZ22_17100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZ22_17110	COG0659	secondary active sulfate transmembrane transporter activity
GZ22_17125	COG1942	4-Oxalocrotonate Tautomerase
GZ22_17130	COG0735	belongs to the Fur family
GZ22_17135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZ22_17140	COG1121	(ABC) transporter
GZ22_17145	COG1937	Protein conserved in bacteria
GZ22_17150	COG2217	Heavy metal translocating P-type atpase
GZ22_17170	COG5577	PFAM Coat F domain
GZ22_17180	COG1393	Belongs to the ArsC family
GZ22_17185	COG0509	glycine decarboxylation via glycine cleavage system
GZ22_17190	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GZ22_17195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZ22_17210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZ22_17215	COG2011	ABC-type metal ion transport system permease component
GZ22_17220	COG1464	Belongs to the NlpA lipoprotein family
GZ22_17225	COG0396	ATPase activity
GZ22_17230	COG0719	Fe-S assembly protein
GZ22_17235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZ22_17240	COG0822	iron-sulfur transferase activity
GZ22_17245	COG0719	Fe-S assembly protein
GZ22_17265	COG3655	Transcriptional regulator
GZ22_17270	COG3739	integral membrane protein
GZ22_17275	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_17280	COG0730	response to heat
GZ22_17285	COG0737	Belongs to the 5'-nucleotidase family
GZ22_17290	COG3377	Domain of unknown function (DUF1805)
GZ22_17310	COG4470	Protein conserved in bacteria
GZ22_17315	COG2445	Protein of unknown function DUF86
GZ22_17320	COG0647	UMP catabolic process
GZ22_17325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GZ22_17330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GZ22_17335	COG0460	homoserine dehydrogenase
GZ22_17340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GZ22_17345	COG0083	homoserine kinase activity
GZ22_17350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GZ22_17355	COG4837	Protein of unknown function (DUF1462)
GZ22_17365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GZ22_17370	COG0316	Belongs to the HesB IscA family
GZ22_17375	COG0346	lactoylglutathione lyase activity
GZ22_17405	COG1252	NADH dehydrogenase
GZ22_17415	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GZ22_17420	COG1268	BioY protein
GZ22_17425	COG0813	purine-nucleoside phosphorylase activity
GZ22_17430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_17445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GZ22_17450	COG2267	carboxylic ester hydrolase activity
GZ22_17455	COG1098	S1 RNA binding domain
GZ22_17460	COG2155	Conserved Protein
GZ22_17465	COG0166	Belongs to the GPI family
GZ22_17470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GZ22_17490	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GZ22_17500	COG2050	protein possibly involved in aromatic compounds catabolism
GZ22_17505	COG1575	Belongs to the MenA family. Type 1 subfamily
GZ22_17510	COG1169	isochorismate synthase
GZ22_17515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GZ22_17525	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GZ22_17530	COG0318	PFAM AMP-dependent synthetase and ligase
GZ22_17535	COG4948	Mandelate Racemase Muconate Lactonizing
GZ22_17560	COG0494	nUDIX hydrolase
GZ22_17570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GZ22_17575	COG0367	asparagine synthase
GZ22_17580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GZ22_17590	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GZ22_17595	COG1744	ABC transporter substrate-binding protein PnrA-like
GZ22_17600	COG0840	transmembrane signaling receptor activity
GZ22_17605	COG0495	leucyl-tRNA aminoacylation
GZ22_17610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZ22_17630	COG1285	pathogenesis
GZ22_17640	COG3880	PFAM UvrB UvrC protein
GZ22_17645	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GZ22_17650	COG0542	response to heat
GZ22_17655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GZ22_17660	COG4956	integral membrane protein (PIN domain superfamily)
GZ22_17665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GZ22_17670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GZ22_17675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZ22_17685	COG1045	serine acetyltransferase
GZ22_17690	COG0215	cysteine-tRNA ligase activity
GZ22_17700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZ22_17705	COG3688	RNA-binding protein containing a PIN domain
GZ22_17715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZ22_17720	COG0250	Participates in transcription elongation, termination and antitermination
GZ22_17725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GZ22_17730	COG0081	regulation of translation
GZ22_17735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GZ22_17740	COG0222	ribosome binding
GZ22_17745	COG2813	Specifically methylates the guanine in position
GZ22_17755	COG0085	RNA polymerase activity
GZ22_17760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZ22_17765	COG1358	cellular component organization or biogenesis
GZ22_17770	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GZ22_17775	COG0049	tRNA binding
GZ22_17780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZ22_17785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZ22_17795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GZ22_17800	COG0088	Forms part of the polypeptide exit tunnel
GZ22_17805	COG0089	rRNA binding
GZ22_17810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GZ22_17815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GZ22_17820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GZ22_17825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GZ22_17830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GZ22_17835	COG0255	Belongs to the universal ribosomal protein uL29 family
GZ22_17840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GZ22_17845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GZ22_17850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GZ22_17855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GZ22_17860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZ22_17865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GZ22_17870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GZ22_17880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GZ22_17885	COG1841	ribosomal large subunit assembly
GZ22_17890	COG0200	Binds to the 23S rRNA
GZ22_17895	COG0201	protein transport
GZ22_17900	COG0563	adenylate kinase activity
GZ22_17910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GZ22_17915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GZ22_17920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GZ22_17930	COG0202	RNA polymerase activity
GZ22_17935	COG0203	ribosomal protein L17
GZ22_17940	COG1122	ATPase activity
GZ22_17945	COG1122	ATPase activity
GZ22_17955	COG0101	tRNA pseudouridine synthase activity
GZ22_17960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GZ22_17965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GZ22_17990	COG0584	glycerophosphoryl diester phosphodiesterase
GZ22_18030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GZ22_18055	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZ22_18060	COG0489	protein tyrosine kinase activity
GZ22_18075	COG0726	polysaccharide deacetylase
GZ22_18080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GZ22_18155	COG3402	PFAM membrane-flanked domain
GZ22_18300	COG0741	lytic transglycosylase activity
GZ22_18300	COG0791	NLP P60 protein
GZ22_18545	COG1192	Involved in chromosome partitioning