locus-tag class description GZ22_00040 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GZ22_00045 ENOG41068WN GZ22_00050 ENOG4105DBI uridine monophosphokinase GZ22_00055 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GZ22_00060 ENOG4107R5R arsenical pump membrane protein GZ22_00065 ENOG41082YX Transcriptional regulator, arsr family GZ22_00090 ENOG4105C26 Dehydrogenase GZ22_00150 ENOG41079KZ Major Facilitator Superfamily GZ22_00165 ENOG4105EMN RNA polymerase sigma factor GZ22_00170 ENOG4105KXB anti-sigma factor GZ22_00175 ENOG4105C8B TIGR00159 family GZ22_00185 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GZ22_00190 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GZ22_00210 ENOG4105BZU Histidine kinase GZ22_00215 ENOG4105WH1 Two component transcriptional regulator luxr family GZ22_00220 ENOG4105CJ1 ABC, transporter GZ22_00245 ENOG4106Z5D Glycoside Hydrolase Family 43 GZ22_00255 ENOG4108ZMX Domain of unknown function (DU1801) GZ22_00260 ENOG4105DJ2 Major Facilitator Superfamily GZ22_00285 ENOG4105BZU Histidine kinase GZ22_00295 ENOG4105F27 Major Facilitator GZ22_00300 ENOG4105WAB arsR family transcriptional regulator GZ22_00305 ENOG4105F27 Major Facilitator GZ22_00320 ENOG4107S1E Beta-lactamase GZ22_00330 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GZ22_00370 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GZ22_00390 ENOG4105CPU Monooxygenase GZ22_00400 ENOG4105DEN Luciferase family GZ22_00410 ENOG4108W0I acetyltransferase GZ22_00415 ENOG4107YZX Universal stress protein GZ22_00420 ENOG4105CHH sulfate transporter GZ22_00425 ENOG4108C33 Resolvase GZ22_00435 ENOG4105CJ1 ABC, transporter GZ22_00480 ENOG4107TXC Transcriptional regulator GZ22_00490 ENOG4105BZW Glycerate kinase GZ22_00500 ENOG4105DAP Nicotinate phosphoribosyltransferase GZ22_00505 ENOG4105K70 DNA-binding protein GZ22_00530 ENOG4105C37 (CBS) domain GZ22_00535 ENOG4108K2B transcriptional regulator GZ22_00565 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GZ22_00575 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GZ22_00585 ENOG4108TM9 integral membrane protein GZ22_00610 ENOG4105J7D transcriptional regulator GZ22_00615 ENOG4105C0R drug resistance transporter emrb qaca subfamily GZ22_00625 ENOG4105XT2 Transcriptional regulator GZ22_00630 ENOG4105DMF Dehydrogenase GZ22_00640 ENOG4105IIP Membrane GZ22_00645 ENOG4105W1N transcriptional regulator GZ22_00650 ENOG4105C26 Dehydrogenase GZ22_00655 ENOG4105C6K Malic enzyme GZ22_00660 ENOG4105CID antiterminator GZ22_00665 ENOG4105C5Y PTS System GZ22_00670 ENOG4105CS2 ec 3.2.1.21 GZ22_00675 ENOG4105EMU Dehydrogenase GZ22_00685 ENOG4105C26 Dehydrogenase GZ22_00700 ENOG4105DEN Luciferase family GZ22_00705 ENOG4108DBC nitroreductase GZ22_00730 ENOG4105E2A Dehydrogenase GZ22_00735 ENOG4106KNT transcriptional regulator GZ22_00740 ENOG4105F8D glycoside hydrolase family 4 GZ22_00745 ENOG4105CI1 PTS System GZ22_00770 ENOG4105ME7 Membrane GZ22_00775 ENOG4108R9S DSBA oxidoreductase GZ22_00785 ENOG41067MG lrgb family GZ22_00790 ENOG4105VAW lrga family GZ22_00795 ENOG4105CMU LysR family (Transcriptional regulator GZ22_00805 ENOG4107VFR oxidoreductase GZ22_00810 ENOG4105CZN Potassium uptake protein GZ22_00815 ENOG4108ZB6 transcriptional regulator AsnC family GZ22_00820 ENOG4105CHM Aminotransferase GZ22_00825 ENOG4105CID antiterminator GZ22_00830 ENOG4105C5Y PTS System GZ22_00835 ENOG4105CS2 ec 3.2.1.21 GZ22_00845 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GZ22_00855 ENOG4105CID antiterminator GZ22_00865 ENOG4105KVH Transcriptional regulator GZ22_00870 ENOG4105F27 Major Facilitator GZ22_00875 ENOG4105CV8 reductase GZ22_00890 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GZ22_00895 ENOG4105DVE abc transporter atp-binding protein GZ22_00925 ENOG4105F38 ABC transporter, permease GZ22_00930 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GZ22_00935 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GZ22_00940 ENOG4105CPN adenine deaminase GZ22_00950 ENOG4105D74 hydrolase GZ22_00965 ENOG4105FKZ Methyl-accepting chemotaxis GZ22_00970 ENOG4105FKZ Methyl-accepting chemotaxis GZ22_00975 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GZ22_01005 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GZ22_01015 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GZ22_01020 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GZ22_01025 ENOG4105E5W Transporter GZ22_01035 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GZ22_01040 ENOG4107SET aldo keto reductase GZ22_01045 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GZ22_01050 ENOG4105X1N Glycosyl transferase family 8 GZ22_01065 ENOG4107XC4 flavin reductase domain protein, FMN-binding GZ22_01075 ENOG4108IJ9 (ABC) transporter GZ22_01090 ENOG4105C54 Major Facilitator superfamily GZ22_01095 ENOG4105J7I hydrolase GZ22_01100 ENOG4105BZ1 (ABC) transporter GZ22_01105 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B GZ22_01110 ENOG4105CFC Transporter GZ22_01125 ENOG4107TT2 Auxin Efflux Carrier GZ22_01130 ENOG4105C6K Malic enzyme GZ22_01150 ENOG4105KVH Transcriptional regulator GZ22_01155 ENOG4107Y2X deaminase GZ22_01160 ENOG4105BZU Histidine kinase GZ22_01170 ENOG410667J hydrolase GZ22_01175 ENOG4105CKK Glycosyl transferase, family 2 GZ22_01185 ENOG4105EJV Membrane GZ22_01195 ENOG4106KNT transcriptional regulator GZ22_01200 ENOG4105CS9 pantothenic acid kinase GZ22_01205 ENOG4105C5Y PTS System GZ22_01210 ENOG4105CG3 alpha amylase, catalytic region GZ22_01215 ENOG4107414 GntR family transcriptional regulator GZ22_01220 ENOG4107TCE N-acetyltransferase GZ22_01235 ENOG4105DXB Major Facilitator superfamily GZ22_01260 ENOG410606W general stress protein GZ22_01265 ENOG4107TUM Amidinotransferase GZ22_01270 ENOG4107QW4 alcohol dehydrogenase GZ22_01275 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GZ22_01290 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GZ22_01295 ENOG4105CZV ABC transporter GZ22_01300 ENOG4105CJ1 ABC, transporter GZ22_01305 ENOG4108TU7 Inherit from COG: (ABC) transporter GZ22_01310 ENOG4108ZHJ Organic hydroperoxide resistance protein GZ22_01335 ENOG4105CJ1 ABC, transporter GZ22_01340 ENOG4108TU7 Inherit from COG: (ABC) transporter GZ22_01365 ENOG4105WMR Protein CrcB homolog GZ22_01380 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GZ22_01390 ENOG4105C8Q Methyl-accepting chemotaxis GZ22_01400 ENOG4105F6S Spore photoproduct lyase GZ22_01405 ENOG4105ETU transcriptional activator (TenA GZ22_01415 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GZ22_01425 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GZ22_01465 ENOG4107TVC Glycosyl transferase, family 2 GZ22_01475 ENOG4105VCH membrane GZ22_01480 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GZ22_01485 ENOG4107SCQ Iron-containing alcohol dehydrogenase GZ22_01495 ENOG4107TPS domain protein GZ22_01510 ENOG4105CPF Cell wall formation (By similarity) GZ22_01520 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase GZ22_01525 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GZ22_01530 ENOG4105CDH Citrulline--aspartate ligase GZ22_01535 ENOG4105CH7 arginosuccinase GZ22_01540 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GZ22_01545 ENOG4108K60 carbamoyl-phosphate synthetase ammonia chain GZ22_01550 ENOG4105DBV ornithine carbamoyltransferase GZ22_01570 ENOG4108R6K riboflavin synthase, subunit alpha GZ22_01580 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GZ22_01585 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GZ22_01610 ENOG4108IXY short-chain dehydrogenase reductase GZ22_01620 ENOG4108V06 Glutathione peroxidase GZ22_01630 ENOG4105C72 UPF0176 protein GZ22_01640 ENOG4105VEQ Cold shock protein GZ22_01650 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GZ22_01660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GZ22_01665 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GZ22_01685 ENOG4106WTF Glycosyl transferase, family 2 GZ22_01705 ENOG4105BZU Histidine kinase GZ22_01710 ENOG4105CI3 gtp-binding protein typa GZ22_01725 ENOG4107R34 abc transporter permease protein GZ22_01730 ENOG4105C19 ABC transporter GZ22_01740 ENOG4105C75 arginyL-tRNA synthetase GZ22_01755 ENOG4105SZ6 Thioredoxin GZ22_01760 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GZ22_01765 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) GZ22_01780 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GZ22_01795 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GZ22_01800 ENOG4105C1J atp-dependent rna helicase GZ22_01805 ENOG410905X membrane-flanked domain protein GZ22_01810 ENOG4105CKV Membrane GZ22_01820 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GZ22_01825 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GZ22_01830 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GZ22_01835 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GZ22_01845 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GZ22_01850 ENOG4107MMM Anti-sigma-factor antagonist GZ22_01855 ENOG4105FUA antagonist GZ22_01860 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GZ22_01865 ENOG4107SGM protein serine threonine phosphatase GZ22_01870 ENOG4105WN5 stage II sporulation protein GZ22_01875 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GZ22_01885 ENOG41064BQ Phosphatase GZ22_01900 ENOG410906U SprT-like GZ22_01990 ENOG4105K8N protein family UPF0079, ATPase GZ22_01995 ENOG41072GX Peptidase M22 Glycoprotease GZ22_02000 ENOG410801F ribosomal-protein-alanine acetyltransferase GZ22_02005 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GZ22_02010 ENOG4105C5H ABC transporter GZ22_02015 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GZ22_02020 ENOG4108IXI (ABC) transporter GZ22_02025 ENOG4105C4B ABC transporter, permease GZ22_02035 ENOG4107YZX Universal stress protein GZ22_02040 ENOG4105C0R drug resistance transporter emrb qaca subfamily GZ22_02055 ENOG4105KVH Transcriptional regulator GZ22_02065 ENOG41090KR LysR family transcriptional Regulator GZ22_02090 ENOG4108UQV Membrane GZ22_02110 ENOG4107TXC Transcriptional regulator GZ22_02155 ENOG4108JCI Transcriptional regulator GZ22_02165 ENOG4105VZ8 Transcriptional regulator GZ22_02175 ENOG4108Z66 YbaK ebsC protein GZ22_02180 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GZ22_02185 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GZ22_02190 ENOG4108UX3 '-nucleotidase GZ22_02205 ENOG4108IQI permease GZ22_02210 ENOG4105EPR degv family GZ22_02240 ENOG4105BZG amino acid carrier protein GZ22_02280 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GZ22_02290 ENOG4108TYN CAAX amino terminal protease family protein GZ22_02295 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GZ22_02300 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GZ22_02310 ENOG4105DZ6 Band 7 protein GZ22_02315 ENOG4105DR4 Methyltransferase GZ22_02325 ENOG4105CFM UPF0317 protein GZ22_02360 ENOG4105DJ2 Major Facilitator Superfamily GZ22_02385 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GZ22_02390 ENOG4105I1K ABC transporter GZ22_02405 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 GZ22_02425 ENOG4105EFI regulatoR GZ22_02440 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) GZ22_02450 ENOG4108UZX fmn reductase GZ22_02460 ENOG4108UAU isochorismatase GZ22_02480 ENOG4108HHA Transketolase GZ22_02485 ENOG4108IUS Transketolase GZ22_02505 ENOG4107YCY Transcriptional regulator GZ22_02520 ENOG4105E2Y ABC, transporter GZ22_02530 ENOG4105C5Y PTS System GZ22_02535 ENOG4105CS2 ec 3.2.1.21 GZ22_02550 ENOG4108V4B ThiJ pfpI GZ22_02555 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B GZ22_02570 ENOG4105EF1 ribulokinase GZ22_02595 ENOG4105CMD Transcriptional regulator, GntR family GZ22_02600 ENOG4108JE9 extracellular solute-binding protein family 1 GZ22_02615 ENOG4105DRS transport system, permease GZ22_02625 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) GZ22_02630 ENOG4108MDK Dehydrogenase GZ22_02640 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GZ22_02690 ENOG4105N14 lysine exporter protein LysE YggA GZ22_02710 ENOG4105KVH Transcriptional regulator GZ22_02715 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GZ22_02720 ENOG4107V0Z fmn reductase GZ22_02760 ENOG4105C85 amino acid GZ22_02775 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GZ22_02780 ENOG4108V9W transcriptional regulatory protein GZ22_02785 ENOG4105D4T Citrate transporter GZ22_02790 ENOG4108Z0Z intracellular protease Pfpi family GZ22_02795 ENOG4108RYK Nad-dependent epimerase dehydratase GZ22_02800 ENOG4108Z40 Transcriptional regulator GZ22_02820 ENOG4105BZU Histidine kinase GZ22_02825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GZ22_02835 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) GZ22_02840 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GZ22_02845 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) GZ22_02850 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GZ22_02860 ENOG41082BV acetyltransferase GZ22_02870 ENOG4105C8Y Acetylornithine aminotransferase GZ22_02875 ENOG4107QM2 Aldo Keto reductase GZ22_02895 ENOG410905X membrane-flanked domain protein GZ22_02935 ENOG4105C8Q Methyl-accepting chemotaxis GZ22_02950 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GZ22_02965 ENOG4105NCW Trka-c domain protein GZ22_02970 ENOG4107S91 Sodium hydrogen exchanger GZ22_02975 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GZ22_02990 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GZ22_03005 ENOG4105C7N Xanthine uracil vitamin C permease GZ22_03015 ENOG4108U5N UPF0316 protein GZ22_03025 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GZ22_03035 ENOG4105C83 adenylosuccinate lyase GZ22_03040 ENOG4105C8V SAICAR synthetase GZ22_03045 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GZ22_03050 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GZ22_03055 ENOG4107QIK phosphoribosylformylglycinamidine synthase GZ22_03065 ENOG4105CXB phosphoribosylaminoimidazole synthetase GZ22_03070 ENOG4108V3E phosphoribosylglycinamide formyltransferase GZ22_03075 ENOG4105DC1 bifunctional purine biosynthesis protein purh GZ22_03080 ENOG4105C12 Phosphoribosylglycinamide synthetase GZ22_03090 ENOG4105KGF protein, YerC YecD GZ22_03095 ENOG4105EE0 oxidoreductase GZ22_03100 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) GZ22_03105 ENOG4105C4R Atp-dependent dna helicase GZ22_03110 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GZ22_03130 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GZ22_03135 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GZ22_03140 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GZ22_03155 ENOG4105CBD Diacylglycerol kinase GZ22_03160 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GZ22_03175 ENOG4106FGC GZ22_03190 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) GZ22_03220 ENOG4105CFC Transporter GZ22_03225 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GZ22_03235 ENOG4107JEE Short-chain dehydrogenase reductase Sdr GZ22_03240 ENOG4108FUT Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GZ22_03255 ENOG4107RSM transcriptional regulator GZ22_03260 ENOG4105C9Q fumarate hydratase class II GZ22_03265 ENOG4108S3Y transcriptional regulator GZ22_03275 ENOG4105CS2 ec 3.2.1.21 GZ22_03300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GZ22_03305 ENOG4105F38 ABC transporter, permease GZ22_03320 ENOG4107SKW Inherit from COG: Alpha beta hydrolase GZ22_03340 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GZ22_03345 ENOG4105CZ9 Domain of unknown function (DU1801) GZ22_03350 ENOG4105KD7 acetyltransferase GZ22_03355 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GZ22_03365 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) GZ22_03370 ENOG4105DFD Na H antiporter GZ22_03375 ENOG4105XN3 extracellular solute-binding protein family 1 GZ22_03380 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component GZ22_03385 ENOG4105EG2 ABC transporter, permease GZ22_03405 ENOG4108YRB methyltransferase GZ22_03410 ENOG4105CRQ synthase (Component I) GZ22_03445 ENOG4105FKZ Methyl-accepting chemotaxis GZ22_03450 ENOG4105C26 Dehydrogenase GZ22_03460 ENOG4105CX8 fg-gap repeat protein GZ22_03480 ENOG4105C5Q Transcriptional regulator GZ22_03485 ENOG4105C34 Pseudouridine synthase GZ22_03515 ENOG4105CI2 imidazolone-5-propionate hydrolase GZ22_03520 ENOG4105C8P )-transporter GZ22_03535 ENOG4105D7N magnesium and cobalt transport protein CorA GZ22_03545 ENOG4105FDP GntR family transcriptional regulator GZ22_03550 ENOG4105F8D glycoside hydrolase family 4 GZ22_03555 ENOG410901P UPF0249 protein GZ22_03590 ENOG4105K4I Scp-like extracellular GZ22_03595 ENOG4105VTS DnaJ-like, subfamily C GZ22_03605 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GZ22_03610 ENOG4105KJF protein tyrosine phosphatase GZ22_03620 ENOG4107U9T Pfam:Ribonuclease_BN GZ22_03630 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein GZ22_03635 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein GZ22_03640 ENOG4105E5Q amino acid AbC transporter GZ22_03645 ENOG4108ISG Major Facilitator GZ22_03670 ENOG4107V2S Transcriptional regulator GZ22_03680 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GZ22_03695 ENOG4105CZV ABC transporter GZ22_03700 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GZ22_03710 ENOG4105X1N Glycosyl transferase family 8 GZ22_03750 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GZ22_03765 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GZ22_03775 ENOG4105DAP Nicotinate phosphoribosyltransferase GZ22_03780 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GZ22_03805 ENOG4105BZ1 (ABC) transporter GZ22_03820 ENOG4105E0M Sulfatase GZ22_03835 ENOG4105E2A Dehydrogenase GZ22_03845 ENOG4105ECP epimerase GZ22_03850 ENOG410902V Modulates RecA activity (By similarity) GZ22_03870 ENOG41067AE Membrane-bound metal-dependent hydrolase GZ22_03875 ENOG4105CEN a g-specific adenine glycosylase GZ22_03885 ENOG4105EVI UPF0374 protein GZ22_03890 ENOG4105BZ1 (ABC) transporter GZ22_03895 ENOG4107NBY Membrane GZ22_03900 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GZ22_03910 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GZ22_03925 ENOG4108WBT adenosyltransferase GZ22_03930 ENOG4105G5W regulator Fur family GZ22_04050 ENOG4105CIS alcohol dehydrogenase GZ22_04060 ENOG4105CPC Aldo Keto reductase GZ22_04095 ENOG4105DSE periplasmic solute binding protein GZ22_04105 ENOG4105N80 Ferric uptake regulator, Fur family GZ22_04110 ENOG4108MEK Metal-binding protein YodA GZ22_04115 ENOG4105DSE periplasmic solute binding protein GZ22_04120 ENOG4105FDK ABC transporter GZ22_04130 ENOG4105CMT Dihydroxyacetone kinase GZ22_04140 ENOG4105EA8 2-Nitropropane dioxygenase GZ22_04160 ENOG4105CVJ phosphoglycerate mutase GZ22_04170 ENOG4108JQ7 (ABC) transporter GZ22_04200 ENOG4105C28 cystathionine GZ22_04205 ENOG4105C28 cystathionine GZ22_04215 ENOG4108UW5 maltose o-acetyltransferase GZ22_04220 ENOG4108RNG Permease of the drug metabolite transporter GZ22_04225 ENOG4105C26 Dehydrogenase GZ22_04230 ENOG4105C0A alcohol dehydrogenase GZ22_04250 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GZ22_04255 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GZ22_04260 ENOG4105C26 Dehydrogenase GZ22_04275 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) GZ22_04280 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GZ22_04290 ENOG4105KRI phosphocarrier protein (HPr GZ22_04295 ENOG4107SET aldo keto reductase GZ22_04300 ENOG4105CF7 AraC family transcriptional regulator GZ22_04310 ENOG4105EYF MMPL domain protein GZ22_04320 ENOG4108ZHJ Organic hydroperoxide resistance protein GZ22_04325 ENOG4105K56 Transcriptional regulator GZ22_04330 ENOG4105CK1 PTS System GZ22_04360 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GZ22_04405 ENOG4105C4M (Ubiquinol oxidase) subunit I GZ22_04410 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GZ22_04415 ENOG4108JJ9 ABC, transporter GZ22_04420 ENOG4108JJ8 (ABC) transporter GZ22_04425 ENOG4105CSC Glucose uptake protein GZ22_04430 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GZ22_04440 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GZ22_04445 ENOG4108RE9 Phosphodiesterase GZ22_04450 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GZ22_04460 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GZ22_04480 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GZ22_04485 ENOG4105FKZ Methyl-accepting chemotaxis GZ22_04490 ENOG4108DBC nitroreductase GZ22_04515 ENOG4105CYN Serine protein kinase GZ22_04525 ENOG4107RSM transcriptional regulator GZ22_04535 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GZ22_04540 ENOG4105C7S Dehydrogenase GZ22_04550 ENOG4108Q8B Spore germination protein GZ22_04560 ENOG4106AKX UPF0229 protein GZ22_04565 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GZ22_04570 ENOG4108V2W Carbonate dehydratase GZ22_04575 ENOG4105BZ1 (ABC) transporter GZ22_04580 ENOG4105BZ1 (ABC) transporter GZ22_04585 ENOG4108WZW RNA polymerase sigma GZ22_04595 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GZ22_04620 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GZ22_04630 ENOG4105C28 cystathionine GZ22_04645 ENOG4105ED1 spovr family GZ22_04675 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GZ22_04690 ENOG4108VCA G U mismatch-specific DNA glycosylase GZ22_04695 ENOG410904N short-chain dehydrogenase reductase GZ22_04710 ENOG4105CJ1 ABC, transporter GZ22_04715 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GZ22_04720 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GZ22_04745 ENOG4108VXD carboxy-peptidase GZ22_04750 ENOG4105C9Q fumarate hydratase class II GZ22_04770 ENOG4105WZB UPF0342 protein GZ22_04775 ENOG4107VRP DNA repair exonuclease GZ22_04785 ENOG4105TRT Transcriptional regulator GZ22_04790 ENOG4105EQI Metal Dependent Phosphohydrolase GZ22_04825 ENOG4108IJ7 Glycine betaine GZ22_04860 ENOG4108AEY RNA polymerase sigma factor GZ22_04885 ENOG4105K59 histidine triad (HIT) protein GZ22_04920 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GZ22_04925 ENOG4105BZ4 penicillin-binding protein GZ22_04930 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GZ22_04935 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GZ22_04940 ENOG4105C1Q protoporphyrinogen oxidase GZ22_04950 ENOG4108RQ5 Beta-lactamase domain-containing protein GZ22_04955 ENOG4105DF9 Lipoate-protein, ligase GZ22_04965 ENOG4105XVF Competence transcription factor GZ22_04985 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination GZ22_04990 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GZ22_05005 ENOG4108QCI YvbH-like oligomerisation region GZ22_05020 ENOG4105CAQ asparagine synthetase GZ22_05025 ENOG4107AYK membrAne GZ22_05040 ENOG4105BZU Histidine kinase GZ22_05045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GZ22_05065 ENOG4108KP7 hydrolase GZ22_05070 ENOG4108MXZ Esterase GZ22_05075 ENOG4105VG1 fes assembly suf system protein GZ22_05100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GZ22_05110 ENOG4105C31 Tryptophanyl-tRNA synthetase GZ22_05120 ENOG4108J59 Extracellular solute-binding protein, family 5 GZ22_05125 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GZ22_05130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GZ22_05140 ENOG4108JQ7 (ABC) transporter GZ22_05155 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) GZ22_05160 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis GZ22_05170 ENOG4105DPN Oligoendopeptidase f GZ22_05190 ENOG4108Z18 K06886 hemoglobin GZ22_05195 ENOG4105MIX Adenylate cyclase GZ22_05205 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GZ22_05210 ENOG4105EMS pseudouridine synthase GZ22_05215 ENOG4107S1Q Phosphatase GZ22_05225 ENOG4105CJW magnesium transporter GZ22_05250 ENOG4105H67 Protein of unknown function (DUF421) GZ22_05270 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GZ22_05275 ENOG4105CC5 ABC transporter GZ22_05285 ENOG4105DIK (ABC) transporter GZ22_05290 ENOG4105DSE periplasmic solute binding protein GZ22_05300 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GZ22_05305 ENOG4107UVV polysaccharide deacetylase GZ22_05315 ENOG4107QJZ Glycosyl transferase, family 2 GZ22_05335 ENOG4105R8C Transcriptional regulator GZ22_05375 ENOG4105C85 amino acid GZ22_05380 ENOG4108U05 Transcriptional regulator GZ22_05385 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 GZ22_05395 ENOG4108HCJ Hydrolase GZ22_05400 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GZ22_05405 ENOG4108UW5 maltose o-acetyltransferase GZ22_05420 ENOG4105KVH Transcriptional regulator GZ22_05425 ENOG4105KHC sulfurtransferase GZ22_05430 ENOG4105CPC Aldo Keto reductase GZ22_05435 ENOG4105FDT acyl-CoA dehydrogenase GZ22_05450 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GZ22_05455 ENOG4108UMI ABC transporter, permease GZ22_05460 ENOG4105D01 (LipO)protein GZ22_05465 ENOG4105ENE Histidine kinase GZ22_05470 ENOG4108VB1 regulatoR GZ22_05485 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GZ22_05495 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GZ22_05520 ENOG4105C7F AcnD-accessory protein PrpF GZ22_05525 ENOG4108KAM Transcriptional regulator GZ22_05545 ENOG4105EQD regulatoR GZ22_05550 ENOG4105C2F Histidine kinase GZ22_05570 ENOG4105CNT hydrolase family 2 GZ22_05585 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) GZ22_05640 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GZ22_05650 ENOG4105F38 ABC transporter, permease GZ22_05660 ENOG410682P Hypothetical protein (DUF2513) GZ22_05685 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GZ22_05690 ENOG4105FS7 Transcriptional regulator GZ22_05695 ENOG4108TVJ Nitroreductase GZ22_05705 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GZ22_05715 ENOG41080TC multidrug resistance protein GZ22_05725 ENOG4106PAW secretion accessory protein EsaA YueB GZ22_05785 ENOG41065RQ ADP-ribosylation crystallin J1 GZ22_05805 ENOG4108RAV Conserved protein GZ22_05810 ENOG4108W7F transporter, permease GZ22_05815 ENOG4108JJB ABC transporter GZ22_05820 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein GZ22_05825 ENOG4108X43 YKOF domain protein GZ22_05840 ENOG4105BZU Histidine kinase GZ22_05865 ENOG4105HHM rdd domain containing protein GZ22_05880 ENOG4105CBD Diacylglycerol kinase GZ22_05885 ENOG4108KGH TRANSCRIPTIONal GZ22_05900 ENOG4105G0J serine threonine protein kinase GZ22_05915 ENOG4105C7B Threonine dehydratase GZ22_05920 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GZ22_05925 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GZ22_05930 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GZ22_05935 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GZ22_05940 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GZ22_05945 ENOG4108ZP8 Acetolactate synthase small subunit GZ22_05950 ENOG4105C7K acetolactate synthase GZ22_05955 ENOG4105C01 Dihydroxy-acid dehydratase GZ22_05970 ENOG4105CJ1 ABC, transporter GZ22_05975 ENOG4105KCT ABC transporter GZ22_05980 ENOG4108ZGX Histidine kinase GZ22_05990 ENOG4105DUX Transporter GZ22_05995 ENOG4105N67 Proton-coupled thiamine transporter YuaJ GZ22_06015 ENOG4105DC8 reductase GZ22_06040 ENOG4105CHM Aminotransferase GZ22_06055 ENOG4105UIN GZ22_06065 ENOG4108UT2 hemolysin iii GZ22_06075 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GZ22_06080 ENOG4105CH2 amidohydrolase GZ22_06085 ENOG4105D8X mechanosensitive ion channel GZ22_06090 ENOG4105D3R alkyl hydroperoxide reductase GZ22_06100 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GZ22_06105 ENOG4105BZ1 (ABC) transporter GZ22_06110 ENOG4105BZ1 (ABC) transporter GZ22_06125 ENOG4107ZYR domain protein GZ22_06135 ENOG4105CN5 Metallo-Beta-Lactamase GZ22_06140 ENOG4106148 UPF0356 protein GZ22_06150 ENOG4108X4Q Hydrolase GZ22_06155 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GZ22_06170 ENOG4105CPP Dehydrogenase, E1 component GZ22_06175 ENOG4105C7S Dehydrogenase GZ22_06190 ENOG4105C94 Transporter GZ22_06200 ENOG4105CXN decarboxylase GZ22_06205 ENOG4105WBI UPF0223 protein GZ22_06210 ENOG4108WQ8 UPF0637 protein GZ22_06220 ENOG4105ECY inositol monophosphatase GZ22_06240 ENOG4105ZPI UPF0358 protein GZ22_06250 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GZ22_06260 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GZ22_06270 ENOG4106UY4 Inherit from COG: Scp-like extracellular GZ22_06290 ENOG4105WUC UPF0298 protein GZ22_06295 ENOG4106H78 methyltransferase GZ22_06300 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GZ22_06305 ENOG4105H20 Sporulation integral membrane protein YlbJ GZ22_06310 ENOG41063PX domain protein GZ22_06315 ENOG4105CDE UPF0348 protein GZ22_06320 ENOG4105KNH Nucleic acid-binding protein GZ22_06335 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GZ22_06345 ENOG41074B2 UPF0747 protein GZ22_06350 ENOG4108V6E Cell division protein mraZ GZ22_06355 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GZ22_06365 ENOG4105CJN penicillin-binding protein GZ22_06370 ENOG4105CJN penicillin-binding protein GZ22_06375 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GZ22_06380 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GZ22_06385 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GZ22_06390 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GZ22_06395 ENOG4105CNI cell division protein FtsW GZ22_06405 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GZ22_06410 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GZ22_06415 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GZ22_06425 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GZ22_06435 ENOG4105WR5 sporulation protein, YlmC YmxH family GZ22_06440 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GZ22_06445 ENOG4105DFA alanine racemase domain protein GZ22_06450 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GZ22_06455 ENOG41067XK integral membrane protein GZ22_06460 ENOG4105DBK s4 domain protein GZ22_06470 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GZ22_06475 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GZ22_06480 ENOG4105C34 Pseudouridine synthase GZ22_06485 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GZ22_06495 ENOG4105CXT aspartate transcarbamylase GZ22_06500 ENOG4105CD3 dihydroorotase GZ22_06505 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GZ22_06515 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GZ22_06520 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GZ22_06525 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GZ22_06530 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GZ22_06535 ENOG4105BZU Histidine kinase GZ22_06540 ENOG4105C7K acetolactate synthase GZ22_06555 ENOG4105JAB phenazine biosynthesis protein, phzf family GZ22_06560 ENOG4108154 Acetyltransferase (GNAT) family GZ22_06565 ENOG4107FCW Abortive infection protein GZ22_06570 ENOG4105F23 Fibronectin-binding protein GZ22_06580 ENOG4105DSJ YicC domain protein GZ22_06585 ENOG4105KC4 UPF0296 protein GZ22_06590 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GZ22_06595 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GZ22_06600 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GZ22_06605 ENOG4105C25 Primosomal protein n' GZ22_06610 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GZ22_06615 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GZ22_06620 ENOG4108ZF3 Phosphatase GZ22_06625 ENOG4105D9P serine threonine protein kinase GZ22_06630 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GZ22_06635 ENOG4105DJV ribulose-phosphate 3-epimerase GZ22_06640 ENOG4105FJ0 thiamine GZ22_06650 ENOG4105VB9 50S ribosomal protein l28 GZ22_06655 ENOG4108ZAA Alkaline-shock protein GZ22_06660 ENOG4105DP4 dak2 domain fusion protein ylov GZ22_06670 ENOG4105EJQ L-serine dehydratase GZ22_06675 ENOG4105CB5 ATP-dependent DNA helicase recG GZ22_06680 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) GZ22_06685 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GZ22_06690 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GZ22_06695 ENOG4105CHR reductase GZ22_06700 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GZ22_06705 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GZ22_06710 ENOG4108CPA Protein of unknown function (DUF1128) GZ22_06715 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GZ22_06720 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GZ22_06725 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GZ22_06735 ENOG4105K5M 30s ribosomal protein S16 GZ22_06740 ENOG4105VB6 UPF0109 protein GZ22_06750 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GZ22_06755 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GZ22_06760 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GZ22_06770 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GZ22_06775 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GZ22_06785 ENOG4105D00 flagellar biosynthetic protein flhB GZ22_06790 ENOG4105CMV Succinyl-CoA synthetase subunit beta GZ22_06795 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GZ22_06800 ENOG4105C79 DNA protecting protein DprA GZ22_06805 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GZ22_06810 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GZ22_06815 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GZ22_06820 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GZ22_06825 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) GZ22_06830 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GZ22_06835 ENOG4108ZC9 flagellar basal-body rod protein flgc GZ22_06840 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GZ22_06845 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GZ22_06850 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GZ22_06865 ENOG4106YF4 Flagellar biosynthesis chaperone GZ22_06880 ENOG410822I Flagellar hook capping protein GZ22_06885 ENOG4108JQA flagellar GZ22_06890 ENOG41068WV flagellar FlbD family protein GZ22_06900 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GZ22_06905 ENOG4105DD5 Flagellar motor switch protein GZ22_06910 ENOG4107YTP response regulator receiver protein GZ22_06920 ENOG4105CN7 Flagellar biosynthetic protein FliP GZ22_06925 ENOG4105VS8 Flagellar biosynthetic protein fliq GZ22_06930 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GZ22_06935 ENOG4105D00 flagellar biosynthetic protein flhB GZ22_06940 ENOG4105D7B Flagellar biosynthesis protein flha GZ22_06945 ENOG4105FZW flagellar biosynthesis regulator FlhF GZ22_06955 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GZ22_06960 ENOG4105CBS Chea signal transduction histidine kinase GZ22_06965 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis GZ22_06975 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GZ22_06980 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GZ22_06990 ENOG4105CE9 30S ribosomal protein S2 GZ22_06995 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GZ22_07000 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GZ22_07005 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GZ22_07015 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GZ22_07020 ENOG4105KNE Phosphatidate cytidylyltransferase GZ22_07025 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GZ22_07030 ENOG4105DZP Membrane-associated zinc metalloprotease GZ22_07035 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GZ22_07040 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GZ22_07045 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GZ22_07050 ENOG4105CHV Transcription elongation factor NusA GZ22_07055 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GZ22_07060 ENOG4105VHM ribosomal protein GZ22_07065 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GZ22_07070 ENOG4105W7A Protein of unknown function (DUF503) GZ22_07075 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GZ22_07085 ENOG4105DTN riboflavin biosynthesis protein ribF GZ22_07090 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GZ22_07095 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GZ22_07105 ENOG4105C1V Peptidase, M16 GZ22_07115 ENOG4105E35 Dipicolinate synthase subunit A GZ22_07120 ENOG4108S0H Dipicolinic acid synthetase, b subunit GZ22_07125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GZ22_07135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GZ22_07140 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GZ22_07150 ENOG4105CNU cell division protein FtsK GZ22_07155 ENOG4105DIH basic membrane GZ22_07160 ENOG4108JQ9 ABC transporter GZ22_07165 ENOG4105UIB (ABC) transporter GZ22_07185 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GZ22_07190 ENOG4105XZV Protein of unknown function (DUF3243) GZ22_07210 ENOG4105CEV competence damage-inducible protein GZ22_07215 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GZ22_07220 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GZ22_07225 ENOG4105D48 metallophosphoesterase GZ22_07230 ENOG4105MCT stage V sporulation protein S GZ22_07235 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GZ22_07250 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GZ22_07255 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GZ22_07265 ENOG4108RMU ferritin dps family protein GZ22_07270 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GZ22_07275 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GZ22_07280 ENOG4106F1P AAA ATPase, central domain protein GZ22_07290 ENOG4108Q8B Spore germination protein GZ22_07295 ENOG4108NHD germination protein GZ22_07300 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GZ22_07305 ENOG4105CXI aluminum resistance protein GZ22_07310 ENOG4105KV4 Transcriptional regulator GZ22_07315 ENOG4105C5F glutamine synthetase GZ22_07340 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GZ22_07360 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GZ22_07370 ENOG4108SVB resolvase GZ22_07375 ENOG4105VPS UPF0291 protein GZ22_07390 ENOG4105VXM UPF0154 protein GZ22_07420 ENOG4107QIV Cytochrome c biogenesis protein GZ22_07440 ENOG4105BZU Histidine kinase GZ22_07450 ENOG4108I0Z Aconitate hydratase GZ22_07460 ENOG4106F1P AAA ATPase, central domain protein GZ22_07470 ENOG4105MI2 GZ22_07475 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GZ22_07480 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) GZ22_07485 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GZ22_07490 ENOG4108IJ8 ABC transporter GZ22_07495 ENOG4105E90 ABC transporter GZ22_07500 ENOG4105K4P CoA-binding domain protein GZ22_07505 ENOG4105CNG UPF0061 protein GZ22_07510 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GZ22_07525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GZ22_07530 ENOG41062D9 Histidine kinase GZ22_07560 ENOG410890F Dynamin family GZ22_07580 ENOG4105GIG GZ22_07585 ENOG4105D9N nucleoside GZ22_07590 ENOG4106P55 Transcriptional regulator GZ22_07595 ENOG4105C2C drug resistance transporter, Bcr CflA GZ22_07605 ENOG4105ST3 Transcriptional regulator GZ22_07610 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GZ22_07640 ENOG41080TC multidrug resistance protein GZ22_07645 ENOG4105CH6 catalase GZ22_07650 ENOG4105EU0 Major facilitator Superfamily GZ22_07670 ENOG410645S MarR family Transcriptional regulator GZ22_07680 ENOG4105FKZ Methyl-accepting chemotaxis GZ22_07685 ENOG4105FKZ Methyl-accepting chemotaxis GZ22_07700 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GZ22_07705 ENOG4108UW5 maltose o-acetyltransferase GZ22_07720 ENOG4108W76 histidinol phosphate phosphatase hisj family GZ22_07725 ENOG4107Z2D Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) GZ22_07730 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GZ22_07735 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GZ22_07740 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GZ22_07750 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GZ22_07755 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GZ22_07760 ENOG41079P0 GZ22_07790 ENOG4105DEN Luciferase family GZ22_07795 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GZ22_07805 ENOG4105C5Q Transcriptional regulator GZ22_07815 ENOG4105BZ8 glutamate synthase GZ22_07820 ENOG4106YBV Methyl-accepting chemotaxis GZ22_07830 ENOG4105CM2 brancheD-chain amino acid aminotransferase GZ22_07850 ENOG4105EWU Squalene--hopene cyclase GZ22_07860 ENOG4105CGK Exodeoxyribonuclease III GZ22_07865 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family GZ22_07890 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GZ22_07895 ENOG4105C9U ATP-dependent DNA helicase RecQ GZ22_07905 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GZ22_07910 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GZ22_07950 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B GZ22_07960 ENOG4105D17 glycoside hydrolase, family 3 domain protein GZ22_07965 ENOG4105EHZ conserved protein UCP016719 GZ22_07970 ENOG4107RSM transcriptional regulator GZ22_07985 ENOG4105E2K Glycosyl transferase (Group 1 GZ22_08000 ENOG410855V Acylphosphatase GZ22_08030 ENOG4108KK1 membrane protein AbrB duplication GZ22_08035 ENOG4107TS3 membrane protein, TerC GZ22_08040 ENOG4105E0X reductase GZ22_08055 ENOG4105EYH Exonuclease GZ22_08060 ENOG4107RFY SbcCD D subunit GZ22_08085 ENOG4105E0M Sulfatase GZ22_08100 ENOG4108CQP Protein of unknown function (DUF1250) GZ22_08120 ENOG4105I3N Conserved Protein GZ22_08125 ENOG4105VEQ Cold shock protein GZ22_08135 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GZ22_08150 ENOG4105CTD carboxy-peptidase GZ22_08155 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GZ22_08170 ENOG4108UKS UPF0398 protein GZ22_08180 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GZ22_08190 ENOG4107QJZ Glycosyl transferase, family 2 GZ22_08220 ENOG4105KG3 cytidine deaminase GZ22_08245 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GZ22_08250 ENOG4105BZ4 penicillin-binding protein GZ22_08255 ENOG4105CSM endonuclease III GZ22_08265 ENOG4105C5S asparaginyl-tRNA synthetase GZ22_08280 ENOG4105DVT helicase GZ22_08285 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GZ22_08290 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GZ22_08305 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GZ22_08310 ENOG4105CPK Glycosyl transferase (Group 1 GZ22_08315 ENOG4108Z5K methylglyoxal synthase GZ22_08320 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GZ22_08325 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GZ22_08330 ENOG4108JYZ YitT family GZ22_08335 ENOG4108Z0Z intracellular protease Pfpi family GZ22_08360 ENOG41068YB TPR repeat-containing protein GZ22_08365 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GZ22_08380 ENOG4105KHN chorismate mutase GZ22_08385 ENOG4105D49 3-dehydroquinate synthase GZ22_08390 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GZ22_08405 ENOG4105BZU Histidine kinase GZ22_08410 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GZ22_08415 ENOG4105EAH synthase GZ22_08420 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GZ22_08430 ENOG4105K70 DNA-binding protein GZ22_08435 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GZ22_08450 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GZ22_08455 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GZ22_08465 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GZ22_08470 ENOG4105E9Q Acyl-transferase GZ22_08475 ENOG4105CAT Cytidine monophosphate kinase GZ22_08485 ENOG4105MSI germination protein ypeb GZ22_08490 ENOG4105F0V Cell wall hydrolase GZ22_08500 ENOG4105HDK L-asparaginase GZ22_08505 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GZ22_08515 ENOG4108S6Z Negative regulator of genetic competence GZ22_08550 ENOG4105BZU Histidine kinase GZ22_08555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GZ22_08560 ENOG4105CRE cytochrome C GZ22_08565 ENOG4107TWT Cytochrome c biogenesis protein GZ22_08575 ENOG4105FE9 pseudouridine synthase GZ22_08585 ENOG4108JIC nucleoside recognition domain protein GZ22_08590 ENOG4105DZ1 carboxypeptidase GZ22_08600 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GZ22_08605 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GZ22_08625 ENOG4107ZE5 PPIases accelerate the folding of proteins GZ22_08630 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GZ22_08640 ENOG4105G6R Stage v sporulation protein ae GZ22_08650 ENOG4105CZ3 stage V sporulation protein ad GZ22_08655 ENOG41090VF Stage v sporulation protein ac GZ22_08670 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GZ22_08675 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GZ22_08680 ENOG41082AN stage II sporulation protein GZ22_08685 ENOG4105DZ1 carboxypeptidase GZ22_08700 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GZ22_08705 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GZ22_08720 ENOG4105MZ9 stage II sporulation protein m GZ22_08725 ENOG4108YZ4 nudix hydrolase GZ22_08730 ENOG4105CPC Aldo Keto reductase GZ22_08740 ENOG4108IXY short-chain dehydrogenase reductase GZ22_08750 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GZ22_08755 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GZ22_08760 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GZ22_08765 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GZ22_08770 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GZ22_08780 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GZ22_08785 ENOG4108QEG Membrane GZ22_08795 ENOG4105C7S Dehydrogenase GZ22_08800 ENOG4105CPP Dehydrogenase, E1 component GZ22_08815 ENOG4105CKM Branched-chain carboxylic acid kinase GZ22_08820 ENOG4107RDP Dehydrogenase GZ22_08830 ENOG4108JUB Transcriptional regulator GZ22_08835 ENOG4105CFH Aspartokinase GZ22_08840 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GZ22_08850 ENOG4105D4B ABC, transporter GZ22_08855 ENOG4105F5R ABC transporter GZ22_08860 ENOG4105CNN ABC, transporter GZ22_08865 ENOG4105C2J ABC transporter GZ22_08870 ENOG4105EQD regulatoR GZ22_08885 ENOG4105E98 transcriptional regulator DeoR family GZ22_08890 ENOG4105DKG l-rhamnose isomerase GZ22_08895 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) GZ22_08900 ENOG4105DET Rhamnulokinase GZ22_08920 ENOG4107QQR Sporulation GZ22_08925 ENOG4105S1Z Stage IV sporulation protein B GZ22_08930 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GZ22_08935 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GZ22_08940 ENOG4105DX0 Hemolysin A GZ22_08945 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GZ22_08950 ENOG4105CTB Polyprenyl synthetase GZ22_08955 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GZ22_08960 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GZ22_08965 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GZ22_08970 ENOG4105M7K Involved in the transcription termination process (By similarity) GZ22_08975 ENOG4108ZSR alkaline shock protein GZ22_08980 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GZ22_08990 ENOG4105BZ1 (ABC) transporter GZ22_08995 ENOG4105BZ1 (ABC) transporter GZ22_09010 ENOG410644B Stage III sporulation protein af GZ22_09020 ENOG4105KQ4 Stage iii sporulation protein ad GZ22_09025 ENOG4108CQH stage III sporulation protein AC GZ22_09030 ENOG4105KR5 Stage iii sporulation protein GZ22_09035 ENOG4105CD2 stage iii sporulation protein aa GZ22_09040 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GZ22_09045 ENOG4105DC7 peptidase M24 GZ22_09060 ENOG4105CBJ Metal-dependent enzyme GZ22_09075 ENOG4105KST dependent repressor GZ22_09080 ENOG4105WZW rhodanese family GZ22_09085 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GZ22_09090 ENOG4108JEM The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GZ22_09095 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GZ22_09100 ENOG4105C0D helicase GZ22_09155 ENOG4105C5X domain protein GZ22_09165 ENOG4105E0M Sulfatase GZ22_09170 ENOG4105DKQ ROK family GZ22_09180 ENOG4105DER m42 family GZ22_09190 ENOG4107ZXI Rhomboid family GZ22_09200 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GZ22_09205 ENOG410861F 50S ribosomal protein L33 GZ22_09220 ENOG4108UTW Plays a role in the regulation of phosphate uptake GZ22_09225 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GZ22_09230 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GZ22_09235 ENOG4105E2Z phosphate ABC transporter (Permease GZ22_09240 ENOG4105C8U phosphate abc transporter GZ22_09245 ENOG4105CVA phosphate GZ22_09250 ENOG4107RF6 penicillin-binding protein GZ22_09310 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GZ22_09325 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GZ22_09335 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GZ22_09340 ENOG4105EGD dinuclear metal center protein, YbgI family GZ22_09350 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GZ22_09355 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GZ22_09360 ENOG4107XJU UPF0178 protein GZ22_09370 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GZ22_09380 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GZ22_09385 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GZ22_09390 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) GZ22_09400 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GZ22_09410 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GZ22_09420 ENOG4105C9A Phoh family GZ22_09430 ENOG41068P3 sporulation protein YqfC GZ22_09440 ENOG4105DI5 UPF0365 protein GZ22_09450 ENOG4105KTH gatB Yqey GZ22_09460 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GZ22_09465 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GZ22_09470 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GZ22_09475 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GZ22_09480 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GZ22_09485 ENOG4105CFG Acts as a chaperone (By similarity) GZ22_09490 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GZ22_09495 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GZ22_09500 ENOG4105CSA Coproporphyrinogen iii oxidase GZ22_09505 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GZ22_09520 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) GZ22_09530 ENOG4105TQK DNA polymerase iii, delta' subunit GZ22_09535 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GZ22_09540 ENOG4108UK2 deaminase GZ22_09545 ENOG4105KQC Competence protein GZ22_09555 ENOG4105DXX methyltransferase GZ22_09560 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GZ22_09565 ENOG4108WF2 Metal Dependent Phosphohydrolase GZ22_09570 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GZ22_09575 ENOG410812S Rna-binding protein GZ22_09580 ENOG4105E2X shikimate dehydrogenase GZ22_09585 ENOG4105CQW ribosome biogenesis GTPase YqeH GZ22_09590 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GZ22_09600 ENOG4105D65 subunit l GZ22_09605 ENOG4108ZE9 Monovalent cation H antiporter subunit C GZ22_09610 ENOG4108JPZ Monovalent cation H antiporter subunit D GZ22_09615 ENOG4105SC1 monovalent cation H antiporter subunit E GZ22_09625 ENOG4105KJM monovalent cation h antiporter subunit g GZ22_09630 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GZ22_09645 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GZ22_09660 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GZ22_09670 ENOG4108VQJ O-methyltransferase GZ22_09675 ENOG4105HHA aminodeoxychorismate lyase GZ22_09685 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GZ22_09690 ENOG4105VBH UPF0297 protein GZ22_09695 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GZ22_09705 ENOG41060CR GZ22_09710 ENOG4105C7H Helicase, RecD TraA family GZ22_09720 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GZ22_09725 ENOG4105C3J Cysteine desulfurase GZ22_09735 ENOG4105D1H recombination factor protein RarA GZ22_09740 ENOG4108VCI transcription factor, rsfa family GZ22_09745 ENOG4105C9M aspartyl-trna synthetase GZ22_09750 ENOG4105CUT histidyl-tRNA synthetase GZ22_09760 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GZ22_09765 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GZ22_09770 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GZ22_09775 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GZ22_09785 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GZ22_09795 ENOG4105CKP Polysaccharide Biosynthesis Protein GZ22_09800 ENOG4108QG2 Membrane GZ22_09805 ENOG4105NAP GZ22_09810 ENOG4105VIE preprotein translocase, subunit YajC GZ22_09815 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GZ22_09820 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GZ22_09830 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GZ22_09835 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GZ22_09855 ENOG4105CQC Prephenate dehydratase GZ22_09865 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GZ22_09875 ENOG4105K46 50S ribosomal protein l27 GZ22_09880 ENOG4105X36 (ribosomal) protein GZ22_09885 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GZ22_09890 ENOG4105C03 ribonuclease GZ22_09910 ENOG4105EN6 Membrane GZ22_09915 ENOG4107QMS site-determining protein GZ22_09920 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GZ22_09930 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GZ22_09935 ENOG4105DFF Rod shape-determining protein mreb GZ22_09940 ENOG4105W5Q DNA repair protein (RadC GZ22_09950 ENOG4106A3R peptidase GZ22_09960 ENOG4105BZU Histidine kinase GZ22_09965 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GZ22_09970 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GZ22_09985 ENOG4105DKW ABC transporter GZ22_09995 ENOG4105WH1 Two component transcriptional regulator luxr family GZ22_10000 ENOG4105ENE Histidine kinase GZ22_10040 ENOG4105JSC dimethylmenaquinone methyltransferase GZ22_10050 ENOG41080TC multidrug resistance protein GZ22_10070 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GZ22_10100 ENOG4105DQ4 alcohol dehydrogenase GZ22_10105 ENOG4105VUF Transcriptional regulator GZ22_10110 ENOG4105CF7 AraC family transcriptional regulator GZ22_10115 ENOG4105CPC Aldo Keto reductase GZ22_10135 ENOG4106UW1 Major Facilitator superfamily GZ22_10145 ENOG4108UZ3 Transporter GZ22_10150 ENOG4108MCI Transcriptional regulator, ARAC family GZ22_10155 ENOG4105E0A ABC, transporter GZ22_10160 ENOG4105TVJ transport system, permease GZ22_10165 ENOG4105DQ5 transport system permease protein GZ22_10175 ENOG4105C85 amino acid GZ22_10195 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GZ22_10210 ENOG41068KH stage VI sporulation protein D GZ22_10210 ENOG41068KH stage VI sporulation protein D GZ22_10220 ENOG4105D52 delta-aminolevulinic acid dehydratase GZ22_10230 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GZ22_10240 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GZ22_10250 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GZ22_10255 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GZ22_10260 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GZ22_10265 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GZ22_10295 ENOG4108VKI Cell wall hydrolase GZ22_10310 ENOG4105EQD regulatoR GZ22_10325 ENOG4105CHR reductase GZ22_10330 ENOG4105DDC Oxidoreductase domain protein GZ22_10340 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GZ22_10345 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GZ22_10350 ENOG410769Z extracellular solute-binding protein family 1 GZ22_10360 ENOG4105E2X shikimate dehydrogenase GZ22_10365 ENOG4105FF2 Type I DHQase GZ22_10375 ENOG4105ETE Transcriptional regulator (LacI family GZ22_10390 ENOG4108SJC Membrane GZ22_10395 ENOG4105M59 Phosphodiesterase, mj0936 family GZ22_10400 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GZ22_10410 ENOG4108XJQ germination protein GZ22_10415 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GZ22_10420 ENOG41067TZ transcriptional regulator, MarR family GZ22_10425 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GZ22_10460 ENOG4105PFC Transcriptional regulator GZ22_10475 ENOG4105WCN acetyltransferase GZ22_10510 ENOG4107Y9E nuclease GZ22_10540 ENOG4108W8B Beta-lactamase domain protein GZ22_10545 ENOG4108IG5 Transcriptional regulator GZ22_10550 ENOG4105E33 succinate dehydrogenase GZ22_10560 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GZ22_10590 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GZ22_10595 ENOG4105K63 Thioredoxin GZ22_10605 ENOG4105C98 muts2 protein GZ22_10610 ENOG4105DCG PHP domain protein GZ22_10620 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GZ22_10625 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GZ22_10640 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GZ22_10645 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GZ22_10650 ENOG4108RWN rrna methyltransferase GZ22_10655 ENOG41067MF small acid-soluble spore protein GZ22_10660 ENOG4105E4C Lytic transglycosylase catalytic GZ22_10665 ENOG4105CN9 Peptidase m42 family protein GZ22_10680 ENOG4108RSN SNARE associated Golgi GZ22_10685 ENOG410696E Membrane GZ22_10690 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GZ22_10695 ENOG4105VJV 50s ribosomal protein L35 GZ22_10700 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GZ22_10715 ENOG4105C22 threonyL-tRNA synthetase GZ22_10735 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GZ22_10740 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GZ22_10745 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GZ22_10750 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GZ22_10755 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GZ22_10760 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GZ22_10765 ENOG4105C2M dna polymerase I GZ22_10770 ENOG4105BZU Histidine kinase GZ22_10775 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GZ22_10780 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GZ22_10785 ENOG4108HMX isocitrate dehydrogenase (NADP) GZ22_10790 ENOG4105BZN citrate synthase GZ22_10800 ENOG4108REF Sporulation integral membrane protein ytvi GZ22_10805 ENOG4105FS0 cytoplasmic membrane protein GZ22_10810 ENOG4105CA9 Pyruvate kinase GZ22_10815 ENOG4105CTQ phosphohexokinase GZ22_10820 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GZ22_10825 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GZ22_10830 ENOG4105C6K Malic enzyme GZ22_10835 ENOG4105C0B DNA polymerase III (alpha subunit) GZ22_10840 ENOG4105VV2 GZ22_10850 ENOG4105SFS phosphoesterase RecJ domain protein GZ22_10860 ENOG4105E8R UPF0173 metal-dependent hydrolase GZ22_10865 ENOG4105DC7 peptidase M24 GZ22_10875 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GZ22_10890 ENOG4105EE1 crotonyl-CoA reductase GZ22_10895 ENOG4108MRH transcriptional regulatory protein GZ22_10905 ENOG4105KBJ sporulation protein ytfj GZ22_10920 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GZ22_10925 ENOG4105C3J Cysteine desulfurase GZ22_10930 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) GZ22_10935 ENOG4105U5Y Transcriptional regulator GZ22_10950 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GZ22_10975 ENOG4107WTH Galactitol-1-phosphate dehydrogenase GZ22_10985 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GZ22_10990 ENOG4105CPQ Dehydrogenase GZ22_10995 ENOG4105DT3 PTS system, galactitol-specific IIc component GZ22_11000 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GZ22_11010 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GZ22_11020 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GZ22_11030 ENOG4105ETE Transcriptional regulator (LacI family GZ22_11035 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GZ22_11040 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GZ22_11045 ENOG4105WDR GZ22_11065 ENOG4105DFU Cell wall formation (By similarity) GZ22_11075 ENOG4108VDD TRNA binding domain protein GZ22_11080 ENOG4108NKM UPF0354 protein GZ22_11090 ENOG4108N3W hemolysin secretion protein GZ22_11115 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GZ22_11125 ENOG4108V15 phosphotransferase enzyme family GZ22_11145 ENOG4107QSE Dipeptidase GZ22_11150 ENOG4105YW5 deoR family transcriptional regulator GZ22_11165 ENOG4105CBX hi0933 family GZ22_11190 ENOG4105CRK lysyL-tRNA synthetase GZ22_11195 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GZ22_11200 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GZ22_11205 ENOG4105KRF dihydroneopterin aldolase GZ22_11210 ENOG4105EEI dihydropteroate synthase GZ22_11215 ENOG4105C6T cysteine synthase GZ22_11220 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GZ22_11225 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GZ22_11230 ENOG4108UGV hypoxanthine phosphoribosyltransferase GZ22_11235 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GZ22_11265 ENOG4107TB6 phosphoglycerate mutase GZ22_11275 ENOG41060GV RNA binding s1 domain protein GZ22_11290 ENOG4105VYY sporulation protein yabp GZ22_11295 ENOG41082I2 s4 domain protein GZ22_11315 ENOG4105E7U AraC family transcriptional regulator GZ22_11320 ENOG4108M14 stage v sporulation protein t GZ22_11325 ENOG4108JA2 transcriptioN-repair coupling factor GZ22_11345 ENOG4105DA5 (ABC) transporter GZ22_11370 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GZ22_11375 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GZ22_11380 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GZ22_11390 ENOG4105DFT pur operon repressor GZ22_11395 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GZ22_11405 ENOG4105W42 Veg protein GZ22_11410 ENOG4105XFA sporulation peptidase YabG GZ22_11415 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GZ22_11420 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GZ22_11425 ENOG4105F8V Hydrolase, tatD family GZ22_11435 ENOG4105KRN Transcriptional regulator, abrb family GZ22_11440 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GZ22_11445 ENOG4105VC4 domain protein GZ22_11450 ENOG41060K3 Methyltransferase GZ22_11455 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) GZ22_11460 ENOG4105MA4 psp1 domain protein GZ22_11465 ENOG4105FA2 dna polymerase iii GZ22_11470 ENOG4105XVJ Protein of unknown function (DUF327) GZ22_11475 ENOG4105X0R protein from nitrogen regulatory protein P-II GZ22_11480 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GZ22_11485 ENOG4105CXN decarboxylase GZ22_11555 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GZ22_11560 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GZ22_11565 ENOG4105C6E dna polymerase iii GZ22_11570 ENOG4108Z6B deaminase GZ22_11575 ENOG4105GTG Isochorismatase GZ22_11580 ENOG4105VRS hydrolase family 18 GZ22_11590 ENOG4107RKG DJ-1/PfpI family GZ22_11600 ENOG4105C26 Dehydrogenase GZ22_11615 ENOG4105E1K spore germination protein GZ22_11625 ENOG4108Q5U germination protein, ger(x)c family GZ22_11640 ENOG4105ZMH deoxynucleoside kinase GZ22_11660 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GZ22_11670 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GZ22_11695 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GZ22_11710 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GZ22_11715 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GZ22_11725 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GZ22_11730 ENOG410848D S4 domain protein YaaA GZ22_11735 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GZ22_11740 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GZ22_11745 ENOG4105VG0 50S ribosomal protein l34 GZ22_11750 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GZ22_11755 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GZ22_11765 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GZ22_11770 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GZ22_11775 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GZ22_11780 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) GZ22_11785 ENOG4107QJE Chromosome Partitioning Protein GZ22_11790 ENOG4105FA0 parb-like partition protein GZ22_11805 ENOG4105D8X mechanosensitive ion channel GZ22_11810 ENOG4105VDK protein, conserved in bacteria GZ22_11815 ENOG4105C3G gtp-binding protein GZ22_11820 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GZ22_11825 ENOG4108UUM single-stranded DNA-binding protein GZ22_11830 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GZ22_11835 ENOG4105C0R drug resistance transporter emrb qaca subfamily GZ22_11840 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GZ22_11850 ENOG4108JQ1 Dehydrogenase GZ22_11855 ENOG4107R7I amino acid GZ22_11870 ENOG4108XMW Membrane GZ22_11875 ENOG4105BZR domain protein GZ22_11880 ENOG41082B8 Binds to the 23S rRNA (By similarity) GZ22_11885 ENOG4105CDU Replicative dna helicase GZ22_11890 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GZ22_11895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GZ22_11900 ENOG4105BZU Histidine kinase GZ22_11915 ENOG4105Q2H domain protein GZ22_11920 ENOG4105C0H protease GZ22_11925 ENOG4105ECB domain protein GZ22_11935 ENOG4105BZU Histidine kinase GZ22_11940 ENOG4105DG6 mannose-6-phosphate isomerase GZ22_11945 ENOG4107RVG penicillin-binding protein GZ22_11955 ENOG4108IQI permease GZ22_11960 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GZ22_11970 ENOG4105C85 amino acid GZ22_11980 ENOG4107WD8 ABC transporter, permease GZ22_11985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GZ22_11990 ENOG4105GR3 Histidine kinase GZ22_11995 ENOG4107G87 m6 family metalloprotease domain protein GZ22_12030 ENOG4105F8D glycoside hydrolase family 4 GZ22_12040 ENOG4105TRI Hydrolase GZ22_12050 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GZ22_12055 ENOG4107R73 Mate efflux family protein GZ22_12080 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GZ22_12085 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GZ22_12105 ENOG4105NIV Esterase GZ22_12155 ENOG4105R40 Glycine betaine carnitine choline GZ22_12160 ENOG4108HQR Glycine betaine GZ22_12165 ENOG4105E90 ABC transporter GZ22_12170 ENOG4108IJ8 ABC transporter GZ22_12225 ENOG4108ZHR arsR family transcriptional regulator GZ22_12230 ENOG4108SQ9 flavin reductase domain protein, FMN-binding GZ22_12235 ENOG4107VXZ Hydrolase GZ22_12240 ENOG4105E98 transcriptional regulator DeoR family GZ22_12245 ENOG4105CS2 ec 3.2.1.21 GZ22_12250 ENOG4105VCP PTS System GZ22_12255 ENOG4105CK1 PTS System GZ22_12270 ENOG4105CJZ response regulator GZ22_12275 ENOG4105EWM Histidine kinase GZ22_12280 ENOG4105C19 ABC transporter GZ22_12285 ENOG4108HVR ABC transporter, permease GZ22_12290 ENOG41090UD (LipO)protein GZ22_12300 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GZ22_12310 ENOG4105C3U ABC transporter GZ22_12315 ENOG4108JQ7 (ABC) transporter GZ22_12335 ENOG4105K5X acetyltransferase GZ22_12350 ENOG4105EHG Permease protein GZ22_12355 ENOG4105DQ5 transport system permease protein GZ22_12375 ENOG4108PSK reductase GZ22_12380 ENOG4105JD4 ATPase yjob GZ22_12385 ENOG4107T5V SNARE associated Golgi GZ22_12395 ENOG4105XPP Protein of unknown function (DUF1275) GZ22_12400 ENOG4108KGH TRANSCRIPTIONal GZ22_12430 ENOG4105KIR Thiol-disulfide oxidoreductase dcc GZ22_12435 ENOG4108M26 parallel beta-helix repeat protein GZ22_12455 ENOG4105KNA -acetyltransferase GZ22_12465 ENOG4105F1N DNA alkylation repair GZ22_12470 ENOG4108URH decarboxylase GZ22_12495 ENOG4108UIN ybak prolyl-trna synthetase associated region GZ22_12500 ENOG4105C3F Signal peptidase i GZ22_12505 ENOG4107RWR Sodium hydrogen exchanger GZ22_12515 ENOG4105D9U N-acetyltransferase GZ22_12520 ENOG4105FCD Major Facilitator GZ22_12525 ENOG4105DY9 regulatoR GZ22_12530 ENOG4108HRK Histidine kinase GZ22_12535 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) GZ22_12540 ENOG4105CHR reductase GZ22_12550 ENOG4105D7K pfkb domain protein GZ22_12555 ENOG4107HP6 Transcriptional regulator GZ22_12560 ENOG4108RTU Aldolase GZ22_12585 ENOG4105PDP Short chain dehydrogenase GZ22_12605 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GZ22_12615 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GZ22_12655 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GZ22_12660 ENOG4105CID antiterminator GZ22_12690 ENOG410814C multidrug resistance protein GZ22_12700 ENOG4105DQ5 transport system permease protein GZ22_12710 ENOG4105CAY ferredoxin--nadp reductase GZ22_12720 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GZ22_12730 ENOG4105MVE transcriptional regulator GZ22_12735 ENOG4105G63 Type III effector Hrp-dependent GZ22_12740 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GZ22_12750 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GZ22_12755 ENOG4105CNI cell division protein FtsW GZ22_12770 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GZ22_12775 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GZ22_12780 ENOG4105CG3 alpha amylase, catalytic region GZ22_12805 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) GZ22_12820 ENOG4105E0A ABC, transporter GZ22_12825 ENOG4105KFN sortase, SrtB family GZ22_12835 ENOG4105EHG Permease protein GZ22_12840 ENOG4105E0A ABC, transporter GZ22_12855 ENOG4108IG5 Transcriptional regulator GZ22_12860 ENOG4105CSH Transporter GZ22_12870 ENOG4108ZMQ domain protein GZ22_12925 ENOG4108TVJ Nitroreductase GZ22_12930 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GZ22_12935 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GZ22_12940 ENOG4105FBA Phospholipase Carboxylesterase GZ22_12945 ENOG4105CS1 NAD(P)H quinone oxidoreductase GZ22_12955 ENOG4105CE1 Ferrous iron transport protein b GZ22_12960 ENOG4105EE0 oxidoreductase GZ22_12970 ENOG410780I phosphoprotein phosphatase activity GZ22_12985 ENOG4105C1J atp-dependent rna helicase GZ22_12990 ENOG4107RF6 penicillin-binding protein GZ22_13005 ENOG4105ETZ PTS System GZ22_13010 ENOG4105F3R pts system mannose fructose sorbose family iid GZ22_13015 ENOG4105D9R oxidoreductase GZ22_13020 ENOG4105C85 amino acid GZ22_13030 ENOG4105C5Y PTS System GZ22_13035 ENOG4105CS2 ec 3.2.1.21 GZ22_13055 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GZ22_13060 ENOG4105C2J ABC transporter GZ22_13065 ENOG4105CNN ABC, transporter GZ22_13080 ENOG4105G63 Type III effector Hrp-dependent GZ22_13105 ENOG4105BZU Histidine kinase GZ22_13120 ENOG4106N3A copper homeostasis protein cutc GZ22_13130 ENOG4105C8J )-transporter GZ22_13135 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GZ22_13140 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GZ22_13145 ENOG4105CI2 imidazolone-5-propionate hydrolase GZ22_13150 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GZ22_13155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GZ22_13165 ENOG4108JQ7 (ABC) transporter GZ22_13185 ENOG4105U3E Transcriptional regulator GZ22_13195 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GZ22_13210 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GZ22_13225 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GZ22_13260 ENOG4105C09 Bile acid GZ22_13275 ENOG4105BZU Histidine kinase GZ22_13295 ENOG4105C85 amino acid GZ22_13300 ENOG41064HX Suppressor of fused protein (SUFU) GZ22_13315 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GZ22_13335 ENOG4105C8Q Methyl-accepting chemotaxis GZ22_13340 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GZ22_13360 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin GZ22_13365 ENOG4105DZC cytosine deaminase GZ22_13440 ENOG4106I4J membrane GZ22_13450 ENOG4105WYW fructose-bisphosphate aldolase GZ22_13455 ENOG4105C2F Histidine kinase GZ22_13460 ENOG4105EQD regulatoR GZ22_13465 ENOG4107FKK extracellular solute-binding protein family 1 GZ22_13470 ENOG4105EDQ levansucrase EC 2.4.1.10 GZ22_13475 ENOG4108HKT sucrose-6-phosphate hydrolase GZ22_13480 ENOG4105C5A transporter GZ22_13485 ENOG4105P4J Allophanate hydrolase, subunit 1 GZ22_13490 ENOG4105E7W lamb ycsf family protein GZ22_13505 ENOG4108JU3 Alkyl hydroperoxide reductase GZ22_13510 ENOG4105D3R alkyl hydroperoxide reductase GZ22_13515 ENOG4105C8Q Methyl-accepting chemotaxis GZ22_13520 ENOG4105G6Z alkaline phosphatase GZ22_13525 ENOG4105VRS hydrolase family 18 GZ22_13535 ENOG4108RNG Permease of the drug metabolite transporter GZ22_13545 ENOG4105KFN sortase, SrtB family GZ22_13560 ENOG4106HBX Transcriptional Regulator AraC Family GZ22_13570 ENOG4105WEF catalase GZ22_13580 ENOG4107ZXU DSBA oxidoreductase GZ22_13590 ENOG4108QY0 Membrane GZ22_13620 ENOG4105C3M thioredoxin reductase GZ22_13625 ENOG41062ES Transcriptional regulator GZ22_13635 ENOG4107RSM transcriptional regulator GZ22_13640 ENOG4106PAW secretion accessory protein EsaA YueB GZ22_13655 ENOG4105JXH GntR family transcriptional regulator GZ22_13660 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GZ22_13665 ENOG4107QR9 Iron-sulfur cluster binding protein GZ22_13670 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) GZ22_13685 ENOG4105BZU Histidine kinase GZ22_13695 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GZ22_13700 ENOG4108UMI ABC transporter, permease GZ22_13705 ENOG4105D01 (LipO)protein GZ22_13720 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GZ22_13760 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GZ22_13765 ENOG4108UW5 maltose o-acetyltransferase GZ22_13790 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GZ22_13800 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GZ22_13810 ENOG4107FKK extracellular solute-binding protein family 1 GZ22_13820 ENOG4105EG2 ABC transporter, permease GZ22_13830 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GZ22_13845 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GZ22_13850 ENOG4105C26 Dehydrogenase GZ22_13855 ENOG4105DJB Major Facilitator Superfamily GZ22_13860 ENOG4105EQX glucarate dehydratase GZ22_13865 ENOG41073TP transcriptional regulator GZ22_13890 ENOG4105C5Y PTS System GZ22_13895 ENOG4105CS2 ec 3.2.1.21 GZ22_13900 ENOG4108URH decarboxylase GZ22_13910 ENOG4107RUE extracellular solute-binding protein family 1 GZ22_13915 ENOG4105D38 putrescine abc transporter GZ22_13920 ENOG4105F38 ABC transporter, permease GZ22_13950 ENOG4107T8Q Glycosyl transferase (Group 1 GZ22_13965 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) GZ22_13975 ENOG4105C5E polysaccharide biosynthesis protein GZ22_13980 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GZ22_13990 ENOG4107T8Q Glycosyl transferase (Group 1 GZ22_13995 ENOG4105C1B dTDP-glucose 4-6-dehydratase GZ22_14025 ENOG4105E0X reductase GZ22_14035 ENOG410667J hydrolase GZ22_14045 ENOG4105EEQ Na H antiporter GZ22_14050 ENOG4105D9N nucleoside GZ22_14055 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GZ22_14085 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GZ22_14110 ENOG4107SDU Methyl-accepting chemotaxis GZ22_14125 ENOG4105CTX dehydratase GZ22_14130 ENOG41080V3 Major Facilitator superfamily GZ22_14140 ENOG4105DRP amino acid AbC transporter GZ22_14145 ENOG4105CDA abc transporter atp-binding protein GZ22_14165 ENOG4105CPC Aldo Keto reductase GZ22_14170 ENOG4105EYF MMPL domain protein GZ22_14175 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GZ22_14185 ENOG4105C26 Dehydrogenase GZ22_14190 ENOG4105FBA Phospholipase Carboxylesterase GZ22_14195 ENOG41090MY MarR family Transcriptional regulator GZ22_14200 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GZ22_14205 ENOG4107VFR oxidoreductase GZ22_14215 ENOG4105E5W Transporter GZ22_14225 ENOG4105PGM cation diffusion facilitator family transporter GZ22_14230 ENOG4105KTU Transcriptional regulator, arsr family GZ22_14235 ENOG4105CHH sulfate transporter GZ22_14250 ENOG4105E5J UV damage endonuclease GZ22_14260 ENOG41087YS Phage shock protein A GZ22_14275 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GZ22_14305 ENOG4105KK4 UPF0060 membrane protein GZ22_14310 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GZ22_14315 ENOG4105E90 ABC transporter GZ22_14320 ENOG4108IJ8 ABC transporter GZ22_14325 ENOG4105E90 ABC transporter GZ22_14355 ENOG4105BZ7 extracellular solute-binding protein family 1 GZ22_14365 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component GZ22_14370 ENOG4108IJ9 (ABC) transporter GZ22_14390 ENOG4105V75 Transcriptional regulator GZ22_14395 ENOG4105CVP deoxyribo-dipyrimidine photolyase GZ22_14400 ENOG4105D01 (LipO)protein GZ22_14405 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GZ22_14410 ENOG4108UMI ABC transporter, permease GZ22_14415 ENOG4105CJ3 phosphate transporter GZ22_14420 ENOG4107GRR phosphate transport regulator GZ22_14425 ENOG4105W8X HesB YadR YfhF-family protein GZ22_14435 ENOG4106PMH Extracellular solute-binding protein family 3 GZ22_14460 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GZ22_14470 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) GZ22_14485 ENOG4108YYS metal-dependent hydrolase (By similarity) GZ22_14490 ENOG4105CHR reductase GZ22_14495 ENOG4105C3M thioredoxin reductase GZ22_14505 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GZ22_14515 ENOG4105ETD TRANSCRIPTIONal GZ22_14525 ENOG4105E14 MotA TolQ exbB proton channel GZ22_14530 ENOG4105ER2 Ompa motb domain protein GZ22_14540 ENOG4107RVV histidinol phosphate phosphatase, hisj family GZ22_14550 ENOG4105ERH Fumarylacetoacetate hydrolase GZ22_14560 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GZ22_14565 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GZ22_14570 ENOG4105CAS nag kinase GZ22_14575 ENOG4105C8Y Acetylornithine aminotransferase GZ22_14580 ENOG4105CIY formyltetrahydrofolate deformylase GZ22_14585 ENOG4108RVA ribokinase GZ22_14590 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GZ22_14600 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GZ22_14605 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) GZ22_14615 ENOG4105KME endoribonuclease L-psp GZ22_14625 ENOG4105EEM helicase GZ22_14630 ENOG4107QPK )-transporter GZ22_14635 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GZ22_14640 ENOG4105DEN Luciferase family GZ22_14650 ENOG4105FBW Monooxygenase GZ22_14690 ENOG4105CPN adenine deaminase GZ22_14700 ENOG4105DV0 amidase (EC 3.5.1.4 GZ22_14710 ENOG4105DFD Na H antiporter GZ22_14715 ENOG4108IJ0 Aspartate ammonia-lyase GZ22_14720 ENOG4105HDK L-asparaginase GZ22_14725 ENOG4108IMY Transcriptional regulator GZ22_14735 ENOG4107Y03 Nitroreductase GZ22_14760 ENOG4105CGH 5'-nucleotidase GZ22_14765 ENOG41069ER domain protein GZ22_14780 ENOG4105CRQ synthase (Component I) GZ22_14785 ENOG4105DDQ anthranilate synthase GZ22_14790 ENOG4108I0Q anthranilate phosphoribosyltransferase GZ22_14795 ENOG4105DK0 Indole-3-glycerol phosphate synthase GZ22_14800 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GZ22_14805 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GZ22_14810 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GZ22_14815 ENOG4108IUX (ABC) transporter GZ22_14820 ENOG4105RHA ABC transporter, permease GZ22_14840 ENOG4105C5H ABC transporter GZ22_14900 ENOG4105WH1 Two component transcriptional regulator luxr family GZ22_14910 ENOG41090WU lipolytic protein G-D-S-L family GZ22_14925 ENOG4105FR1 rard protein GZ22_14930 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GZ22_14940 ENOG4105FKZ Methyl-accepting chemotaxis GZ22_14950 ENOG4105DWF phosphomethylpyrimidine kinase GZ22_14955 ENOG4105C5H ABC transporter GZ22_14965 ENOG4105C9U ATP-dependent DNA helicase RecQ GZ22_14970 ENOG4105C37 (CBS) domain GZ22_14985 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GZ22_14990 ENOG4105CZM Major Facilitator GZ22_15005 ENOG4107TS3 membrane protein, TerC GZ22_15010 ENOG4108X3M OsmC Ohr family protein GZ22_15020 ENOG4105DSE periplasmic solute binding protein GZ22_15030 ENOG4105DQE DNA ligase GZ22_15035 ENOG4105FDF Could be involved in DNA repair (By similarity) GZ22_15085 ENOG4107JTW chlorite dismutase GZ22_15090 ENOG4108IJ2 phosphate acetyltransferase GZ22_15095 ENOG4105BZU Histidine kinase GZ22_15100 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GZ22_15105 ENOG4105DCI Phosphohydrolase GZ22_15125 ENOG4108XFG YwhD family GZ22_15130 ENOG4105BZ4 penicillin-binding protein GZ22_15135 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GZ22_15160 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) GZ22_15165 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GZ22_15170 ENOG410812K response regulator receiver protein GZ22_15175 ENOG4105D2N Aldolase GZ22_15180 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GZ22_15185 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GZ22_15190 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GZ22_15195 ENOG41082DI 50s ribosomal protein l31 GZ22_15200 ENOG4107104 thymidine kinase GZ22_15210 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GZ22_15215 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GZ22_15220 ENOG4108ZXQ stage ii sporulation protein r GZ22_15230 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GZ22_15245 ENOG4108YZG isomerase GZ22_15250 ENOG4108UIC UPF0340 protein GZ22_15255 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GZ22_15260 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GZ22_15265 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GZ22_15270 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GZ22_15280 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GZ22_15290 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GZ22_15295 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GZ22_15300 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GZ22_15305 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GZ22_15310 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GZ22_15315 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GZ22_15320 ENOG4106778 Protein of unknown function (DUF1146) GZ22_15335 ENOG4108ME1 Peptidase M55 D-aminopeptidase GZ22_15340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GZ22_15345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GZ22_15350 ENOG4105C3U ABC transporter GZ22_15360 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GZ22_15365 ENOG4105DTQ mandelate racemase muconate lactonizing GZ22_15370 ENOG4107SN7 NLP P60 protein GZ22_15380 ENOG4105FRN stage II sporulation protein GZ22_15390 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GZ22_15395 ENOG4105DFF Rod shape-determining protein mreb GZ22_15405 ENOG4105CGA flagellar basal-body rod protein FlgG GZ22_15420 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GZ22_15450 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GZ22_15465 ENOG4105CHR reductase GZ22_15495 ENOG4105CJR Integral membrane protein (MviN GZ22_15515 ENOG4105ESV Glycosyl transferase, family 4 GZ22_15525 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase GZ22_15535 ENOG4107SJB teichoic acid biosynthesis GZ22_15555 ENOG4105CG5 Glycosyl transferase (Group 1 GZ22_15570 ENOG4105EY8 ABC transporter GZ22_15610 ENOG4105D4T Citrate transporter GZ22_15625 ENOG4105EVU fructokinase GZ22_15635 ENOG4105CMR udp-glucose 4-epimerase GZ22_15640 ENOG4108428 Inherit from COG: -acetyltransferase GZ22_15645 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GZ22_15655 ENOG4107JM4 Tetratricopeptide repeat GZ22_15660 ENOG4107QMU Mate efflux family protein GZ22_15680 ENOG4105FTQ Dna gyrase GZ22_15695 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GZ22_15700 ENOG4105HTX biosynthesis protein GZ22_15705 ENOG4107YJ4 chain length determinant protein GZ22_15710 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GZ22_15715 ENOG4105D3Q Sugar transferase GZ22_15725 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GZ22_15730 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GZ22_15750 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GZ22_15760 ENOG4108RCF TRANSCRIPTIONal GZ22_15805 ENOG4105C6Y Udp-glucose 6-dehydrogenase GZ22_15820 ENOG4105CS2 ec 3.2.1.21 GZ22_15825 ENOG41061ZR Transcriptional regulator GZ22_15830 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GZ22_15840 ENOG4107R33 ppx gppa phosphatase GZ22_15845 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GZ22_15880 ENOG4107QZ7 Cellulose synthase catalytic subunit GZ22_15895 ENOG4105C26 Dehydrogenase GZ22_15915 ENOG4105CKI cobalamin synthesis protein GZ22_15920 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GZ22_15925 ENOG4105CKI cobalamin synthesis protein GZ22_15930 ENOG4105E2D ec 3.2.1.52 GZ22_15935 ENOG4105C8Q Methyl-accepting chemotaxis GZ22_15940 ENOG4107YHD transcriptional regulator GZ22_15955 ENOG4105VZJ PTS System GZ22_15960 ENOG4105VCP PTS System GZ22_15965 ENOG4105CK1 PTS System GZ22_15970 ENOG4105CS2 ec 3.2.1.21 GZ22_15975 ENOG4108TZY GntR Family Transcriptional Regulator GZ22_15980 ENOG4106KNT transcriptional regulator GZ22_15990 ENOG4105CMG Carbohydrate kinase GZ22_15995 ENOG4105C6Z Gluconate GZ22_16000 ENOG4106CAD Protein of unknown function (DUF3311) GZ22_16005 ENOG4105E1V na solute symporter GZ22_16010 ENOG4108VP3 Lysine exporter protein (LysE YggA) GZ22_16015 ENOG4105E7U AraC family transcriptional regulator GZ22_16025 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth GZ22_16055 ENOG4108XNA Gas vesicle GZ22_16060 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GZ22_16085 ENOG41067SE Tetr family transcriptional regulator GZ22_16090 ENOG4105VZJ PTS System GZ22_16095 ENOG4105CK1 PTS System GZ22_16100 ENOG4105VCP PTS System GZ22_16105 ENOG4105EMD TRANSCRIPTIONal GZ22_16130 ENOG41062A4 Transcriptional regulator GZ22_16135 ENOG4105EYF MMPL domain protein GZ22_16150 ENOG4107S9D Alpha beta hydrolase GZ22_16170 ENOG4105PAD Hydrolase GZ22_16180 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GZ22_16185 ENOG4105FGV Chromate GZ22_16190 ENOG4105FGV Chromate GZ22_16205 ENOG4105CTQ phosphohexokinase GZ22_16230 ENOG4107QP6 Xylose isomerase domain protein TIM barrel GZ22_16240 ENOG4105C32 Amino acid ABC transporter (Permease) GZ22_16245 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GZ22_16250 ENOG4105C0Z ABC transporter GZ22_16255 ENOG4108IV0 ABC, transporter GZ22_16260 ENOG4106KNT transcriptional regulator GZ22_16290 ENOG4105JXH GntR family transcriptional regulator GZ22_16310 ENOG4105FDP GntR family transcriptional regulator GZ22_16315 ENOG4105CE4 GlcNAc 6-P deacetylase GZ22_16320 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GZ22_16325 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GZ22_16330 ENOG4105BZU Histidine kinase GZ22_16350 ENOG41081UC Inherit from COG: Competence protein GZ22_16355 ENOG4105RU3 GZ22_16370 ENOG4105E1Q flagellar hook-associated protein GZ22_16375 ENOG4105DTJ flagellar hook-associated protein GZ22_16385 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) GZ22_16390 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GZ22_16395 ENOG4105I03 Flagellin GZ22_16400 ENOG4107R0E Glycosyl transferase, family 2 GZ22_16410 ENOG4107SJB teichoic acid biosynthesis GZ22_16415 ENOG4106SCS STAS domain GZ22_16420 ENOG4105CHR reductase GZ22_16425 ENOG41083S7 flagellar protein FlaG GZ22_16430 ENOG4107RT6 flagellar hook-associated GZ22_16435 ENOG4105MQ3 flagellar protein FliS GZ22_16445 ENOG4105MS2 ribosomal subunit Interface protein GZ22_16455 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GZ22_16460 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GZ22_16470 ENOG4105CAK Cell division ATP-binding protein ftsE GZ22_16475 ENOG4105CRP Part of the ABC transporter FtsEX involved in GZ22_16480 ENOG4105DR5 peptidase GZ22_16485 ENOG4105CN1 protease GZ22_16505 ENOG4105C0D helicase GZ22_16515 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GZ22_16520 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GZ22_16525 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GZ22_16535 ENOG4108TN2 lmbE family GZ22_16540 ENOG4108PY7 GZ22_16545 ENOG41086DT Membrane protein of unknown function GZ22_16550 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GZ22_16555 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GZ22_16560 ENOG4107XGZ Hydrolase GZ22_16565 ENOG4108S4C acetyltransferase GZ22_16570 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GZ22_16580 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GZ22_16585 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GZ22_16595 ENOG4105C3M thioredoxin reductase GZ22_16600 ENOG4108Z4K mutator MutT protein GZ22_16605 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GZ22_16610 ENOG4105CHW UPF0052 protein GZ22_16615 ENOG4105CIE May be required for sporulation (By similarity) GZ22_16620 ENOG4105KRI phosphocarrier protein (HPr GZ22_16625 ENOG4105D07 Signal peptide peptidase, SppA GZ22_16630 ENOG4105VK3 rdd domain containing protein GZ22_16635 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GZ22_16700 ENOG4105C7K acetolactate synthase GZ22_16705 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GZ22_16715 ENOG4105WEF catalase GZ22_16730 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GZ22_16750 ENOG4105BZU Histidine kinase GZ22_16755 ENOG4105DWV Homoserine O-trans-acetylase GZ22_16795 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GZ22_16800 ENOG4107S2N Type III effector Hrp-dependent GZ22_16805 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GZ22_16810 ENOG4105UQX Mate efflux family protein GZ22_16820 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GZ22_16825 ENOG4105BZA Phosphoglycerate kinase GZ22_16830 ENOG4105CP7 Triose-phosphate isomerase GZ22_16840 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GZ22_16890 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GZ22_16895 ENOG4107VG4 Xylose isomerase domain protein TIM barrel GZ22_16900 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GZ22_16905 ENOG4105KRI phosphocarrier protein (HPr GZ22_16910 ENOG4105DM4 PTS System GZ22_16915 ENOG4105DE4 1-phosphofructokinase GZ22_16920 ENOG4105E98 transcriptional regulator DeoR family GZ22_16925 ENOG4105XZU Preprotein translocase, subunit SecG GZ22_16935 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GZ22_16945 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GZ22_16950 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GZ22_16965 ENOG4105D4A Cell wall formation (By similarity) GZ22_16980 ENOG4105BZU Histidine kinase GZ22_16985 ENOG4108Y6J UPF0403 protein GZ22_16995 ENOG4107T5V SNARE associated Golgi GZ22_17000 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GZ22_17025 ENOG41069B3 Small, acid-soluble spore protein Tlp GZ22_17035 ENOG4105DHS permease protein GZ22_17040 ENOG4105CM4 permease protein GZ22_17045 ENOG4108IPW abc transporter atp-binding protein GZ22_17065 ENOG4105F27 Major Facilitator GZ22_17080 ENOG4105BZ9 Cytochrome C oxidase, subunit I GZ22_17095 ENOG4105FDT acyl-CoA dehydrogenase GZ22_17100 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GZ22_17110 ENOG4105CHH sulfate transporter GZ22_17125 ENOG41069HH 4-oxalocrotonate tautomerase GZ22_17130 ENOG4105N80 Ferric uptake regulator, Fur family GZ22_17135 ENOG4105FAV ABC, transporter GZ22_17140 ENOG4105FDK ABC transporter GZ22_17145 ENOG4105VPX protein, conserved in bacteria GZ22_17150 ENOG4105C59 p-type ATPase GZ22_17180 ENOG4105KUZ arsenate reductase GZ22_17185 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GZ22_17210 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GZ22_17215 ENOG4108UMI ABC transporter, permease GZ22_17220 ENOG4105D01 (LipO)protein GZ22_17225 ENOG4105C3K feS assembly ATPase SufC GZ22_17230 ENOG4105JRK feS assembly protein SufD GZ22_17235 ENOG4105C9B Cysteine desulfurase GZ22_17240 ENOG4108UNV SUF system FeS assembly protein, NifU family GZ22_17245 ENOG4105DIW FeS assembly protein SUFB GZ22_17265 ENOG4105VMP Transcriptional regulator GZ22_17270 ENOG4105NX3 Membrane GZ22_17275 ENOG4105CHR reductase GZ22_17285 ENOG4107R8B 5'-nucleotidase GZ22_17290 ENOG4105KZD Domain of unknown function (DUF1805) GZ22_17295 ENOG4105CPI Metal Dependent Phosphohydrolase GZ22_17300 ENOG4108YTE sporulation protein YunB GZ22_17310 ENOG4105MMD transcriptional regulator GZ22_17320 ENOG4105D4U had-superfamily hydrolase, subfamily iia GZ22_17325 ENOG4108W5N phosphatidylglycerophosphatase a GZ22_17335 ENOG4105D6E homoserine dehydrogenase GZ22_17340 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GZ22_17350 ENOG41083MR nifu domain-containing protein GZ22_17360 ENOG4105ZKE UPF0349 protein GZ22_17365 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GZ22_17370 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GZ22_17375 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GZ22_17405 ENOG4105CEP NADH dehydrogenase GZ22_17425 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GZ22_17430 ENOG4105KRI phosphocarrier protein (HPr GZ22_17440 ENOG4105Y38 Kinase-associated protein B GZ22_17445 ENOG4105C87 Aminotransferase class I and II GZ22_17450 ENOG4108MUZ hydrolase GZ22_17460 ENOG4105WG9 Conserved Protein GZ22_17465 ENOG4107QYV phosphohexose isomerase GZ22_17470 ENOG4107PBV potassium channel GZ22_17485 ENOG4105CN9 Peptidase m42 family protein GZ22_17490 ENOG4108SAX Membrane GZ22_17500 ENOG4105KA0 thioesterase Superfamily protein GZ22_17505 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GZ22_17510 ENOG4105E4F Isochorismate synthase GZ22_17515 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GZ22_17525 ENOG4108IPT Naphthoate synthase GZ22_17530 ENOG4105CEY Amp-dependent synthetase and ligase GZ22_17535 ENOG4105DTQ mandelate racemase muconate lactonizing GZ22_17565 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GZ22_17570 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GZ22_17575 ENOG4105CAQ asparagine synthetase GZ22_17580 ENOG4108Z0R Transferase GZ22_17595 ENOG4107TFB basic membrane GZ22_17600 ENOG4105C8Q Methyl-accepting chemotaxis GZ22_17605 ENOG4105C8T Leucyl-tRNA synthetase GZ22_17610 ENOG41085GJ domain protein GZ22_17630 ENOG4105KT7 mgtC SapB transporter GZ22_17640 ENOG4108Z0C Uvrb UvrC protein GZ22_17645 ENOG41066A3 ATP guanido phosphotransferase GZ22_17650 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GZ22_17655 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GZ22_17660 ENOG4105CTP PilT protein domain protein GZ22_17665 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GZ22_17670 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GZ22_17675 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GZ22_17685 ENOG4105D7W serine acetyltransferase GZ22_17690 ENOG4105C8N cysteinyl-tRNA synthetase GZ22_17700 ENOG4105C2N RNA methyltransferase TrmH family group 3 GZ22_17705 ENOG4105M0M Tetracycline resistance protein GZ22_17710 ENOG4105QIV RNA polymerase GZ22_17720 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GZ22_17725 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GZ22_17730 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GZ22_17735 ENOG4108VZM 50s ribosomal protein L10 GZ22_17740 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GZ22_17745 ENOG4107Y49 methyltransferase GZ22_17755 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GZ22_17760 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GZ22_17765 ENOG4105XPM ribosomal protein GZ22_17770 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GZ22_17775 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GZ22_17780 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GZ22_17795 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GZ22_17800 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GZ22_17805 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GZ22_17810 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GZ22_17815 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GZ22_17820 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GZ22_17825 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GZ22_17830 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GZ22_17835 ENOG41082SA 50s ribosomal protein l29 GZ22_17840 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GZ22_17845 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GZ22_17850 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GZ22_17855 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GZ22_17860 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GZ22_17865 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GZ22_17870 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GZ22_17880 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GZ22_17885 ENOG4105VPB 50S ribosomal protein L30 GZ22_17890 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GZ22_17895 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GZ22_17900 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GZ22_17910 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GZ22_17920 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GZ22_17925 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GZ22_17930 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GZ22_17935 ENOG4108ZT0 50S ribosomal protein l17 GZ22_17940 ENOG4108JJB ABC transporter GZ22_17945 ENOG4108JJB ABC transporter GZ22_17950 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GZ22_17955 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GZ22_17960 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GZ22_17965 ENOG4108UJD 30S ribosomal protein S9 GZ22_17990 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GZ22_18060 ENOG4105D1F ATP-binding protein GZ22_18075 ENOG4108NMV polysaccharide deacetylase GZ22_18080 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GZ22_18155 ENOG410905X membrane-flanked domain protein GZ22_18250 ENOG4105C9U ATP-dependent DNA helicase RecQ GZ22_18300 ENOG4105K4H Nlp p60 protein GZ22_18545 ENOG4107QJE Chromosome Partitioning Protein