locus-tag class description FTW19_00005 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FTW19_00010 ENOG4105BZF Glycosyl transferase (Group 1 FTW19_00025 ENOG4105VEQ Cold shock protein FTW19_00040 ENOG4105C3J Cysteine desulfurase FTW19_00045 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FTW19_00055 ENOG41063ZK Transcriptional Regulator AraC Family FTW19_00060 ENOG4108Z4V iron-sulfur cluster assembly FTW19_00085 ENOG4108ZIT Ferredoxin, 2FE-2S FTW19_00095 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FTW19_00105 ENOG4105BZU Histidine kinase FTW19_00115 ENOG41082A2 Alpha beta hydrolase FTW19_00160 ENOG4105CSR polyphosphate kinase 2 FTW19_00180 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_00210 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FTW19_00230 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FTW19_00285 ENOG41087WU FTW19_00290 ENOG4105BZU Histidine kinase FTW19_00295 ENOG4105BZU Histidine kinase FTW19_00315 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FTW19_00335 ENOG4105KME endoribonuclease L-psp FTW19_00340 ENOG4105E0X reductase FTW19_00345 ENOG4105C9M aspartyl-trna synthetase FTW19_00350 ENOG4108RVA ribokinase FTW19_00365 ENOG4105CPC Aldo Keto reductase FTW19_00390 ENOG4105K46 50S ribosomal protein l27 FTW19_00395 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FTW19_00405 ENOG4105IIU Aminopeptidase FTW19_00410 ENOG4105CUT histidyl-tRNA synthetase FTW19_00420 ENOG4105CHR reductase FTW19_00430 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FTW19_00435 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FTW19_00440 ENOG4105GYT Protein of unknown function (DUF1009) FTW19_00445 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FTW19_00455 ENOG41069ER domain protein FTW19_00460 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FTW19_00475 ENOG4108HRK Histidine kinase FTW19_00480 ENOG4105DY9 regulatoR FTW19_00490 ENOG41087F1 30S ribosomal protein S21 FTW19_00500 ENOG4105EMN RNA polymerase sigma factor FTW19_00510 ENOG4108Z0R Transferase FTW19_00525 ENOG4108KQ5 Integrase catalytic subunit FTW19_00530 ENOG4105R8A Heat shock protein FTW19_00535 ENOG4108YYS metal-dependent hydrolase (By similarity) FTW19_00545 ENOG4105VB9 50S ribosomal protein l28 FTW19_00550 ENOG4105CPQ Dehydrogenase FTW19_00555 ENOG4105CHR reductase FTW19_00560 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_00570 ENOG4105C59 p-type ATPase FTW19_00580 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FTW19_00590 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FTW19_00605 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FTW19_00610 ENOG4105VFB Binds the 23S rRNA (By similarity) FTW19_00640 ENOG4105C6T cysteine synthase FTW19_00670 ENOG4105DAA L-lactate FTW19_00680 ENOG4105CWX Alpha-1,2-mannosidase FTW19_00690 ENOG4105D6E homoserine dehydrogenase FTW19_00695 ENOG4107Y2X deaminase FTW19_00710 ENOG4105VT2 5-hydroxyisourate hydrolase FTW19_00720 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FTW19_00760 ENOG4105C0R drug resistance transporter emrb qaca subfamily FTW19_00765 ENOG4105D3W isochorismatase FTW19_00790 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FTW19_00795 ENOG4105C1J atp-dependent rna helicase FTW19_00800 ENOG4105CI2 imidazolone-5-propionate hydrolase FTW19_00805 ENOG4107YV3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FTW19_00810 ENOG4105FE9 pseudouridine synthase FTW19_00815 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FTW19_00820 ENOG4105C28 cystathionine FTW19_00825 ENOG4105C28 cystathionine FTW19_00830 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FTW19_00850 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FTW19_00855 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FTW19_00865 ENOG4105XRQ Xanthine dehydrogenase accessory factor FTW19_00870 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FTW19_00895 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FTW19_00900 ENOG4108UVJ appr-1-p processing domain protein FTW19_00920 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FTW19_00925 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FTW19_00935 ENOG4108YYS metal-dependent hydrolase (By similarity) FTW19_00955 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FTW19_00970 ENOG41080HT Transcriptional regulator, arsr family FTW19_00990 ENOG4105BZU Histidine kinase FTW19_00995 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FTW19_01055 ENOG4105CWX Alpha-1,2-mannosidase FTW19_01065 ENOG4105CHP RNA polymerase FTW19_01070 ENOG4105GRZ Ycii-related protein FTW19_01100 ENOG4107RGD Major Facilitator superfamily FTW19_01120 ENOG4105DRR Transcriptional regulator, GntR family FTW19_01145 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FTW19_01150 ENOG4105BZU Histidine kinase FTW19_01155 ENOG4105BZU Histidine kinase FTW19_01180 ENOG4108JNI Alpha beta hydrolase FTW19_01200 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FTW19_01205 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FTW19_01225 ENOG4105CJ3 phosphate transporter FTW19_01230 ENOG4105GRZ Ycii-related protein FTW19_01235 ENOG4105CHP RNA polymerase FTW19_01245 ENOG4107QM5 aconitate hydratase FTW19_01270 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FTW19_01295 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FTW19_01310 ENOG4105BZU Histidine kinase FTW19_01340 ENOG4105CMS peptidase U62, modulator of DNA gyrase FTW19_01345 ENOG4105FGE Short-chain dehydrogenase reductase Sdr FTW19_01350 ENOG4105D1U peptidase U62 modulator of DNA gyrase FTW19_01380 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FTW19_01385 ENOG4105BZU Histidine kinase FTW19_01390 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FTW19_01400 ENOG4108Z18 K06886 hemoglobin FTW19_01405 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FTW19_01435 ENOG4107RSM transcriptional regulator FTW19_01445 ENOG4107X8C Efflux transporter RND family MFP subunit FTW19_01450 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FTW19_01465 ENOG4105C7W Xanthine dehydrogenase FTW19_01470 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FTW19_01475 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FTW19_01490 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FTW19_01495 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FTW19_01500 ENOG4105DK0 Indole-3-glycerol phosphate synthase FTW19_01535 ENOG4106UW1 Major Facilitator superfamily FTW19_01540 ENOG4108JJ7 ABC transporter FTW19_01545 ENOG41061MV Arylsulfatase FTW19_01575 ENOG4108KPZ tonB-dependent Receptor FTW19_01630 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FTW19_01650 ENOG4105EMN RNA polymerase sigma factor FTW19_01670 ENOG4105EVN Prephenate dehydrogenase FTW19_01675 ENOG4105WVQ Fe-S assembly protein IscX FTW19_01690 ENOG4105CJR Integral membrane protein (MviN FTW19_01695 ENOG4108M8H domain protein FTW19_01720 ENOG4105EMN RNA polymerase sigma factor FTW19_01725 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase FTW19_01730 ENOG4105CQC Prephenate dehydratase FTW19_01735 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FTW19_01740 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FTW19_01750 ENOG4105C0R drug resistance transporter emrb qaca subfamily FTW19_01760 ENOG4105C7B Threonine dehydratase FTW19_01770 ENOG4108YYC ycei family FTW19_01780 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FTW19_01785 ENOG4105BZU Histidine kinase FTW19_01790 ENOG4108YXG UPF0502 protein FTW19_01795 ENOG4107RSM transcriptional regulator FTW19_01800 ENOG4108MJ3 acetyltransferase FTW19_01825 ENOG4107R1I NAD-dependent malic enzyme FTW19_01830 ENOG4105CBX hi0933 family FTW19_01860 ENOG4105EXC Acyl-transferase FTW19_01870 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_01875 ENOG4107QQG Dehydrogenase FTW19_01880 ENOG4108IAJ Nad-dependent epimerase dehydratase FTW19_01895 ENOG4105CCU oxidase (Subunit III) FTW19_01940 ENOG4107SFQ iron-sulfur binding FTW19_01965 ENOG4105EMN RNA polymerase sigma factor FTW19_01975 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FTW19_01980 ENOG4105EJ2 Transcriptional regulator FTW19_01985 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FTW19_02015 ENOG4105KHC sulfurtransferase FTW19_02025 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FTW19_02065 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FTW19_02075 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FTW19_02095 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FTW19_02100 ENOG4107YU2 histidine triad (hIT) protein FTW19_02115 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FTW19_02120 ENOG4107QN2 dihydrolipoyl dehydrogenase FTW19_02125 ENOG4105CC0 LysR family Transcriptional regulator FTW19_02140 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_02145 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FTW19_02150 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FTW19_02155 ENOG4105C7W Xanthine dehydrogenase FTW19_02165 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FTW19_02170 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FTW19_02175 ENOG4105FUA antagonist FTW19_02180 ENOG4107MMM Anti-sigma-factor antagonist FTW19_02185 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_02195 ENOG4105DIN metallophosphoesterase FTW19_02210 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_02230 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FTW19_02250 ENOG4105JQZ Methyltransferase FTW19_02280 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FTW19_02300 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_02315 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FTW19_02335 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FTW19_02340 ENOG4105VG0 50S ribosomal protein l34 FTW19_02355 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FTW19_02360 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FTW19_02380 ENOG4105C22 threonyL-tRNA synthetase FTW19_02415 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FTW19_02430 ENOG4107RBB ABC transporter, permease FTW19_02440 ENOG4105E0F Histidine kinase FTW19_02445 ENOG4105E3W Two component transcriptional regulator (Winged helix family FTW19_02460 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FTW19_02500 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FTW19_02525 ENOG4105K70 DNA-binding protein FTW19_02530 ENOG4105JQN Transcriptional regulator FTW19_02550 ENOG4105EMU Dehydrogenase FTW19_02555 ENOG4105EN6 Membrane FTW19_02575 ENOG4107QJE Chromosome Partitioning Protein FTW19_02580 ENOG4107XKH Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FTW19_02585 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FTW19_02595 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FTW19_02605 ENOG4105VIE preprotein translocase, subunit YajC FTW19_02610 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FTW19_02615 ENOG4107QT7 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FTW19_02630 ENOG4105SG9 biopolymer transport protein, ExbD FTW19_02635 ENOG4105M8F Biopolymer transport protein exbD tolR FTW19_02640 ENOG4105SG9 biopolymer transport protein, ExbD FTW19_02670 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FTW19_02680 ENOG4108V06 Glutathione peroxidase FTW19_02685 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FTW19_02695 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FTW19_02705 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FTW19_02730 ENOG4105CDU Replicative dna helicase FTW19_02740 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FTW19_02755 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FTW19_02760 ENOG4107QRI Phosphoketolase FTW19_02780 ENOG4105KVH Transcriptional regulator FTW19_02785 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FTW19_02790 ENOG4105C6T cysteine synthase FTW19_02810 ENOG4108KPZ tonB-dependent Receptor FTW19_02815 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FTW19_02835 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FTW19_02840 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FTW19_02860 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FTW19_02875 ENOG4105C9K Endothelin-converting enzyme 1 FTW19_02900 ENOG4108IDZ Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FTW19_02915 ENOG4105VMP Transcriptional regulator FTW19_02940 ENOG4108HRK Histidine kinase FTW19_02945 ENOG4108VAC response regulator FTW19_02960 ENOG4107TPY serine threonine protein kinase FTW19_02970 ENOG41066YJ Beta-lactamase FTW19_02985 ENOG4108KQ5 Integrase catalytic subunit FTW19_02990 ENOG410804D Sensor Signal Transduction Histidine Kinase FTW19_02995 ENOG4105E3W Two component transcriptional regulator (Winged helix family FTW19_03015 ENOG4105C72 UPF0176 protein FTW19_03115 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_03145 ENOG4105WH1 Two component transcriptional regulator luxr family FTW19_03155 ENOG4105FFC UPF0187 protein FTW19_03170 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) FTW19_03180 ENOG4105VEJ Heat shock protein FTW19_03190 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FTW19_03200 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FTW19_03215 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_03225 ENOG41080Y5 BioY family FTW19_03245 ENOG4108X0B nad(p)h dehydrogenase (quinone) FTW19_03250 ENOG4105CPD ethanolamine ammonia-lyase FTW19_03255 ENOG4107FQ9 ethanolamine ammonia-lyase FTW19_03275 ENOG4105C98 muts2 protein FTW19_03295 ENOG4107QN2 dihydrolipoyl dehydrogenase FTW19_03300 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FTW19_03315 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FTW19_03325 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FTW19_03335 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FTW19_03355 ENOG4105C12 Phosphoribosylglycinamide synthetase FTW19_03360 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FTW19_03365 ENOG4105DZP Membrane-associated zinc metalloprotease FTW19_03370 ENOG4106H78 methyltransferase FTW19_03375 ENOG4108Z03 MAF-like protein FTW19_03385 ENOG4108Z86 Glutamine amidotransferase FTW19_03395 ENOG4108RIR Molybdenum cofactor biosynthesis protein FTW19_03405 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FTW19_03415 ENOG4108J2R molybdopterin oxidoreductase FTW19_03435 ENOG41067VY 50S ribosomal protein L32 FTW19_03440 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FTW19_03445 ENOG4105BZU Histidine kinase FTW19_03460 ENOG4108A04 Beta-lactamase FTW19_03465 ENOG4105HHA aminodeoxychorismate lyase FTW19_03480 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FTW19_03500 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FTW19_03505 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FTW19_03515 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_03540 ENOG4105ETE Transcriptional regulator (LacI family FTW19_03555 ENOG4105EBR Carboxylesterase FTW19_03560 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FTW19_03565 ENOG4105EGE secreted protein FTW19_03595 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FTW19_03615 ENOG4105BZU Histidine kinase FTW19_03620 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FTW19_03650 ENOG4108Z4T Peptidase M50 FTW19_03655 ENOG4105C31 Tryptophanyl-tRNA synthetase FTW19_03665 ENOG4105C5H ABC transporter FTW19_03670 ENOG4108KPZ tonB-dependent Receptor FTW19_03670 ENOG4108KPZ tonB-dependent Receptor FTW19_03690 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FTW19_03695 ENOG4108JEM The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FTW19_03700 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FTW19_03705 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FTW19_03725 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FTW19_03735 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FTW19_03765 ENOG4105C7B Threonine dehydratase FTW19_03770 ENOG4105BZU Histidine kinase FTW19_03775 ENOG4105BZU Histidine kinase FTW19_03795 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FTW19_03800 ENOG4105C34 Pseudouridine synthase FTW19_03810 ENOG4107R4J Chloride channel FTW19_03815 ENOG4108IEG Formate dehydrogenase Alpha subunit FTW19_03835 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FTW19_03840 ENOG4105C8N cysteinyl-tRNA synthetase FTW19_03845 ENOG4107VXZ Hydrolase FTW19_03900 ENOG4105F0N pyrophosphate phospho-hydrolase FTW19_03925 ENOG4108ZM9 phosphoglycerate mutase FTW19_03930 ENOG4108KPZ tonB-dependent Receptor FTW19_03935 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FTW19_03985 ENOG4108KPZ tonB-dependent Receptor FTW19_04070 ENOG4108HRK Histidine kinase FTW19_04075 ENOG4105DY9 regulatoR FTW19_04150 ENOG4105EAQ (twin-arginine translocation) pathway signal FTW19_04170 ENOG41083TY UPF0102 protein FTW19_04175 ENOG4105FDR Membrane FTW19_04180 ENOG4105CNT hydrolase family 2 FTW19_04215 ENOG4108KPZ tonB-dependent Receptor FTW19_04255 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FTW19_04290 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FTW19_04305 ENOG4105EZR dyp-type peroxidase family protein FTW19_04310 ENOG4108IGT Dipeptidase FTW19_04330 ENOG4105CF1 Alkylated DNA repair protein FTW19_04420 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FTW19_04425 ENOG41085TN Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FTW19_04450 ENOG4105DJV ribulose-phosphate 3-epimerase FTW19_04460 ENOG4105BZU Histidine kinase FTW19_04465 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FTW19_04475 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FTW19_04480 ENOG4107URM 50S ribosomal protein l10 FTW19_04485 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FTW19_04490 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FTW19_04495 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FTW19_04525 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FTW19_04560 ENOG4108RYK Nad-dependent epimerase dehydratase FTW19_04580 ENOG4105CPF Cell wall formation (By similarity) FTW19_04595 ENOG4105C5S asparaginyl-tRNA synthetase FTW19_04615 ENOG41080UQ Transcriptional regulator FTW19_04625 ENOG4108JSS Haloalkane dehalogenase FTW19_04630 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FTW19_04635 ENOG4107SFI Major Facilitator superfamily FTW19_04660 ENOG4105C0X amino acid FTW19_04685 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E FTW19_04695 ENOG4105C0H protease FTW19_04705 ENOG4105EMN RNA polymerase sigma factor FTW19_04715 ENOG4105BZU Histidine kinase FTW19_04735 ENOG4108IG5 Transcriptional regulator FTW19_04740 ENOG4105C0R drug resistance transporter emrb qaca subfamily FTW19_04745 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FTW19_04755 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FTW19_04760 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FTW19_04775 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FTW19_04780 ENOG4105EEI dihydropteroate synthase FTW19_04785 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FTW19_04795 ENOG4108KPJ rna polymerase sigma factor FTW19_04800 ENOG4105IIU Aminopeptidase FTW19_04805 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FTW19_04820 ENOG4105BZS acriflavin resistance protein FTW19_04835 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FTW19_04845 ENOG4105CVJ phosphoglycerate mutase FTW19_04855 ENOG4105C5R Aminotransferase FTW19_04865 ENOG4106032 Glutathionylspermidine synthase FTW19_04875 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FTW19_04890 ENOG4108JA2 transcriptioN-repair coupling factor FTW19_04895 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FTW19_04925 ENOG4108V3E phosphoribosylglycinamide formyltransferase FTW19_04930 ENOG4105CXB phosphoribosylaminoimidazole synthetase FTW19_04935 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FTW19_04940 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FTW19_04945 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_04955 ENOG4108ZJ4 polysaccharide deacetylase FTW19_04970 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FTW19_04980 ENOG4105C0H protease FTW19_04985 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FTW19_04990 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FTW19_05000 ENOG4107RBB ABC transporter, permease FTW19_05010 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FTW19_05015 ENOG4105KME endoribonuclease L-psp FTW19_05020 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FTW19_05030 ENOG4105C1P efflux transporter, rnd family, mfp subunit FTW19_05035 ENOG4108IG5 Transcriptional regulator FTW19_05040 ENOG4105CNG UPF0061 protein FTW19_05050 ENOG4108KPZ tonB-dependent Receptor FTW19_05060 ENOG4105WH1 Two component transcriptional regulator luxr family FTW19_05065 ENOG4108XG2 Histidine kinase FTW19_05070 ENOG4105DJB Major Facilitator Superfamily FTW19_05075 ENOG4105CD3 dihydroorotase FTW19_05095 ENOG4105KME endoribonuclease L-psp FTW19_05120 ENOG4105DNP FAD linked oxidase domain protein FTW19_05125 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FTW19_05135 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FTW19_05140 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FTW19_05145 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FTW19_05150 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FTW19_05170 ENOG4105BZU Histidine kinase FTW19_05180 ENOG4108KPZ tonB-dependent Receptor FTW19_05205 ENOG4108R85 Short chain dehydrogenase FTW19_05210 ENOG4105CXK mandelate racemase muconate lactonizing FTW19_05225 ENOG4108KPZ tonB-dependent Receptor FTW19_05230 ENOG4108IUK alpha amylase, catalytic FTW19_05240 ENOG4105CS2 ec 3.2.1.21 FTW19_05255 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FTW19_05260 ENOG4105E2R ROK family FTW19_05265 ENOG4108KPZ tonB-dependent Receptor FTW19_05285 ENOG4108KPZ tonB-dependent Receptor FTW19_05345 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FTW19_05360 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FTW19_05365 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FTW19_05370 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FTW19_05375 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FTW19_05380 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FTW19_05400 ENOG4108KPZ tonB-dependent Receptor FTW19_05415 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FTW19_05425 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FTW19_05435 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FTW19_05460 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FTW19_05475 ENOG4108Z9K Osmotically inducible protein FTW19_05490 ENOG4108KPZ tonB-dependent Receptor FTW19_05500 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FTW19_05510 ENOG4105C3F Signal peptidase i FTW19_05515 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FTW19_05530 ENOG4105EMN RNA polymerase sigma factor FTW19_05555 ENOG4105DJY efflux transporter, rnd family, mfp subunit FTW19_05565 ENOG4105KJJ Uncharacterized ACR, COG1993 FTW19_05570 ENOG4108IND Tetr family transcriptional regulator FTW19_05585 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FTW19_05595 ENOG4105CHU acetyl-coa acetyltransferase FTW19_05605 ENOG4105D6N CoA-transferase, subunit a FTW19_05610 ENOG4105C1G acyl-Coa dehydrogenase FTW19_05615 ENOG4107QX3 carboxylase FTW19_05625 ENOG4108UKI Enoyl-CoA hydratase FTW19_05630 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FTW19_05635 ENOG4105MIR Phenylalanine 4-monooxygenase FTW19_05640 ENOG4105F1J Homogentisate 1,2-dioxygenase FTW19_05665 ENOG4105BZU Histidine kinase FTW19_05675 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FTW19_05705 ENOG4108KPZ tonB-dependent Receptor FTW19_05710 ENOG4107R7I amino acid FTW19_05725 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FTW19_05755 ENOG4105DG4 malate L-lactate dehydrogenase FTW19_05765 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FTW19_05770 ENOG4105E6M Sulphatase-modifying factor protein FTW19_05785 ENOG4105D2S major facilitator superfamily FTW19_05795 ENOG4105ERH Fumarylacetoacetate hydrolase FTW19_05810 ENOG4105ETE Transcriptional regulator (LacI family FTW19_05815 ENOG4105ENH Sulfatase FTW19_05825 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FTW19_05835 ENOG4108KPZ tonB-dependent Receptor FTW19_05860 ENOG4105BZU Histidine kinase FTW19_05865 ENOG4105BZU Histidine kinase FTW19_05875 ENOG4105F2Z 3-oxoadipate enol-lactonase FTW19_05885 ENOG4108NEV two component transcriptional regulator, LytTR family FTW19_05890 ENOG4108HRK Histidine kinase FTW19_05905 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FTW19_05910 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FTW19_05915 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FTW19_05920 ENOG4105DDI hemolysin-type calcium-binding region FTW19_05930 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FTW19_05935 ENOG4107QRT dEAD DEAH box helicase FTW19_05980 ENOG4105E6M Sulphatase-modifying factor protein FTW19_05985 ENOG41067HS methyltransferase FTW19_05995 ENOG4105EX0 alpha-galactosidase FTW19_06020 ENOG4108WUH Transcriptional regulator, TetR family FTW19_06025 ENOG4105EMU Dehydrogenase FTW19_06045 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FTW19_06050 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FTW19_06070 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FTW19_06090 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FTW19_06100 ENOG4105DVT helicase FTW19_06105 ENOG4107TDE lipolytic protein G-D-S-L family FTW19_06115 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase FTW19_06120 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FTW19_06130 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FTW19_06145 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FTW19_06165 ENOG4105BZU Histidine kinase FTW19_06170 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_06180 ENOG4105CNU cell division protein FtsK FTW19_06185 ENOG4105CN5 Metallo-Beta-Lactamase FTW19_06190 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FTW19_06200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_06205 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FTW19_06215 ENOG4105C88 aminopeptidase FTW19_06220 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FTW19_06225 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FTW19_06230 ENOG4105CFH Aspartokinase FTW19_06235 ENOG4107QK3 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11 FTW19_06270 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FTW19_06280 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FTW19_06300 ENOG4105C28 cystathionine FTW19_06315 ENOG4105E3W Two component transcriptional regulator (Winged helix family FTW19_06350 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FTW19_06355 ENOG4105D49 3-dehydroquinate synthase FTW19_06360 ENOG4108IYU L-aspartate oxidase FTW19_06365 ENOG4105DU1 integral membrane protein, terc FTW19_06375 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FTW19_06380 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FTW19_06385 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FTW19_06400 ENOG4105N80 Ferric uptake regulator, Fur family FTW19_06405 ENOG4105D3R alkyl hydroperoxide reductase FTW19_06410 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FTW19_06415 ENOG4105IIU Aminopeptidase FTW19_06435 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) FTW19_06440 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) FTW19_06445 ENOG4105Z85 coenzyme PQQ synthesis FTW19_06450 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E FTW19_06465 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FTW19_06480 ENOG41083YU F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FTW19_06485 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FTW19_06490 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FTW19_06495 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FTW19_06500 ENOG41082VD Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FTW19_06520 ENOG4107RVG penicillin-binding protein FTW19_06535 ENOG4105BZU Histidine kinase FTW19_06540 ENOG4105BZU Histidine kinase FTW19_06575 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FTW19_06580 ENOG4105C9X ppx gppa phosphatase FTW19_06590 ENOG4108KQ5 Integrase catalytic subunit FTW19_06645 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FTW19_06650 ENOG4105C3J Cysteine desulfurase FTW19_06665 ENOG4105BZN citrate synthase FTW19_06670 ENOG4108DN8 FAD dependent oxidoreductase FTW19_06685 ENOG4105DCG PHP domain protein FTW19_06690 ENOG4105VEQ Cold shock protein FTW19_06700 ENOG41074B2 UPF0747 protein FTW19_06710 ENOG4105C1Q protoporphyrinogen oxidase FTW19_06730 ENOG4105EPD Oligopeptide transporter, Opt family FTW19_06740 ENOG41081UC Inherit from COG: Competence protein FTW19_06770 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_06780 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FTW19_06810 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FTW19_06815 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FTW19_06840 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FTW19_06845 ENOG4108UJD 30S ribosomal protein S9 FTW19_06850 ENOG4105CE9 30S ribosomal protein S2 FTW19_06855 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FTW19_06860 ENOG4105E0Y RtcB Protein FTW19_06880 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FTW19_06895 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FTW19_06900 ENOG4105CUB amino acid FTW19_06915 ENOG4108URH decarboxylase FTW19_06920 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FTW19_06925 ENOG41082CH UPF0145 protein FTW19_06930 ENOG4107QYG anthranilate phosphoribosyltransferase FTW19_06940 ENOG4105CMV Succinyl-CoA synthetase subunit beta FTW19_06945 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FTW19_06955 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FTW19_06965 ENOG4107104 thymidine kinase FTW19_06970 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FTW19_06980 ENOG4105DU6 RNA polymerase FTW19_07000 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FTW19_07005 ENOG4108VCA G U mismatch-specific DNA glycosylase FTW19_07020 ENOG4108V06 Glutathione peroxidase FTW19_07040 ENOG4105BZM domain protein FTW19_07045 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FTW19_07050 ENOG4105KME endoribonuclease L-psp FTW19_07055 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FTW19_07065 ENOG4105CV1 Transketolase (EC 2.2.1.1) FTW19_07070 ENOG4108J5G 6-phosphogluconate dehydrogenase FTW19_07075 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FTW19_07080 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) FTW19_07085 ENOG4105CHC glucokinase (EC 2.7.1.2) FTW19_07090 ENOG4105VC4 domain protein FTW19_07115 ENOG41089UC methyltransferase, type 11 FTW19_07120 ENOG41082YX Transcriptional regulator, arsr family FTW19_07125 ENOG41090KN UPF0303 protein FTW19_07135 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FTW19_07150 ENOG4108KPZ tonB-dependent Receptor FTW19_07160 ENOG41080V7 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FTW19_07170 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FTW19_07175 ENOG4105QE3 oxidoreductase FTW19_07180 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_07185 ENOG4105ES5 Histidine kinase FTW19_07190 ENOG4105X1Q TOBE domain protein FTW19_07195 ENOG4108KPZ tonB-dependent Receptor FTW19_07200 ENOG4105DCF alanine dehydrogenase FTW19_07210 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FTW19_07220 ENOG4107RVG penicillin-binding protein FTW19_07225 ENOG4105CNI cell division protein FtsW FTW19_07230 ENOG4105C03 ribonuclease FTW19_07230 ENOG4105C03 ribonuclease FTW19_07245 ENOG4107RAQ aminopeptidase FTW19_07255 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FTW19_07270 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FTW19_07275 ENOG4105DQ4 alcohol dehydrogenase FTW19_07280 ENOG4105CF7 AraC family transcriptional regulator FTW19_07285 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FTW19_07290 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) FTW19_07300 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FTW19_07310 ENOG4108RWI nicotinamidase FTW19_07350 ENOG4105EN6 Membrane FTW19_07370 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FTW19_07375 ENOG4105D82 Glutamate dehydrogenase FTW19_07385 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FTW19_07395 ENOG4108IJ0 Aspartate ammonia-lyase FTW19_07405 ENOG4107GFK fumarate FTW19_07415 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FTW19_07420 ENOG4105BZU Histidine kinase FTW19_07435 ENOG4105DJY efflux transporter, rnd family, mfp subunit FTW19_07450 ENOG4105EMU Dehydrogenase FTW19_07455 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 FTW19_07460 ENOG4105WH1 Two component transcriptional regulator luxr family FTW19_07485 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FTW19_07495 ENOG4107ZR7 Membrane FTW19_07500 ENOG4105CPQ Dehydrogenase FTW19_07505 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FTW19_07510 ENOG4108YYC ycei family FTW19_07525 ENOG4105C3M thioredoxin reductase FTW19_07540 ENOG4105C26 Dehydrogenase FTW19_07545 ENOG4108ZJ4 polysaccharide deacetylase FTW19_07555 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FTW19_07560 ENOG4108XHQ (2Fe-2S)-binding domain protein FTW19_07565 ENOG410645S MarR family Transcriptional regulator FTW19_07580 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FTW19_07615 ENOG4105GVR general secretion pathway protein D FTW19_07620 ENOG4105E4G Type IV pilus FTW19_07645 ENOG4105CJQ hydrolase, family 31 FTW19_07675 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FTW19_07685 ENOG4105CKK Glycosyl transferase, family 2 FTW19_07775 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_07790 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FTW19_07855 ENOG4105E3B Multicopper oxidase FTW19_07870 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FTW19_07875 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FTW19_07880 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FTW19_07885 ENOG4108S3Y transcriptional regulator FTW19_07890 ENOG4105CIG ABC transporter FTW19_07915 ENOG4108UKI Enoyl-CoA hydratase FTW19_07920 ENOG4105E39 Enoyl-CoA hydratase FTW19_07925 ENOG4105CR4 methylisocitrate lyase FTW19_07930 ENOG4105BZN citrate synthase FTW19_07935 ENOG4105DXD 2-methylcitrate dehydratase FTW19_07945 ENOG4108ZX5 transcriptional regulator FTW19_07960 ENOG4105CBD Diacylglycerol kinase FTW19_07980 ENOG4105C8Y Acetylornithine aminotransferase FTW19_07990 ENOG4108JPW Aminotransferase FTW19_08000 ENOG4105C26 Dehydrogenase FTW19_08010 ENOG4105ECP epimerase FTW19_08020 ENOG41067SE Tetr family transcriptional regulator FTW19_08025 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FTW19_08030 ENOG4105FAW cDP-glucose 4,6-dehydratase FTW19_08035 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FTW19_08040 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FTW19_08045 ENOG4105CKK Glycosyl transferase, family 2 FTW19_08075 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) FTW19_08085 ENOG4105CHR reductase FTW19_08090 ENOG4105D49 3-dehydroquinate synthase FTW19_08100 ENOG4105FAW cDP-glucose 4,6-dehydratase FTW19_08115 ENOG4105DJB Major Facilitator Superfamily FTW19_08125 ENOG4105CHR reductase FTW19_08130 ENOG4105DZG Dehydrogenase FTW19_08140 ENOG410854A Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FTW19_08145 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FTW19_08160 ENOG4105VEQ Cold shock protein FTW19_08175 ENOG4105BZU Histidine kinase FTW19_08230 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_08265 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_08270 ENOG4108KPZ tonB-dependent Receptor FTW19_08280 ENOG4107MV2 Inherit from COG: Hemolysin-type calcium-binding FTW19_08325 ENOG4105CNA YD repeat protein FTW19_08340 ENOG4105VTR Integrase FTW19_08355 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FTW19_08365 ENOG4105DC1 bifunctional purine biosynthesis protein purh FTW19_08375 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FTW19_08385 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FTW19_08435 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FTW19_08450 ENOG4105C7K acetolactate synthase FTW19_08455 ENOG4105C01 Dihydroxy-acid dehydratase FTW19_08460 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FTW19_08465 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FTW19_08470 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FTW19_08475 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FTW19_08480 ENOG4105DUM transcriptional regulator, lysR family FTW19_08530 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FTW19_08540 ENOG4105BZU Histidine kinase FTW19_08555 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FTW19_08560 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FTW19_08565 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FTW19_08570 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FTW19_08620 ENOG4105MHT Transcriptional regulator, ARSR family FTW19_08630 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_08635 ENOG4105E2X shikimate dehydrogenase FTW19_08645 ENOG4107S5I aldo keto reductase FTW19_08665 ENOG4105C7B Threonine dehydratase FTW19_08675 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FTW19_08690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_08695 ENOG4105DZG Dehydrogenase FTW19_08710 ENOG4105G6Z alkaline phosphatase FTW19_08715 ENOG4105C0R drug resistance transporter emrb qaca subfamily FTW19_08725 ENOG4105JAB phenazine biosynthesis protein, phzf family FTW19_08745 ENOG4108IUX (ABC) transporter FTW19_08755 ENOG4105C2M dna polymerase I FTW19_08760 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FTW19_08770 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FTW19_08775 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FTW19_08830 ENOG4108ESX Receptor FTW19_08835 ENOG4107E2E PKHD-type hydroxylase FTW19_08850 ENOG4108V6E Cell division protein mraZ FTW19_08855 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FTW19_08865 ENOG4105CJN penicillin-binding protein FTW19_08870 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FTW19_08880 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FTW19_08885 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FTW19_08890 ENOG4105CNI cell division protein FtsW FTW19_08895 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FTW19_08925 ENOG4107QHF type ii secretion system protein e FTW19_08980 ENOG4105YVS arsR family transcriptional regulator FTW19_09030 ENOG4105CPK Glycosyl transferase (Group 1 FTW19_09035 ENOG4105D3Q Sugar transferase FTW19_09125 ENOG4105DKQ ROK family FTW19_09130 ENOG4105CMG Carbohydrate kinase FTW19_09150 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_09160 ENOG4105DQ6 Transposase FTW19_09185 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_09190 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_09205 ENOG4105CN1 protease FTW19_09210 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FTW19_09215 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_09225 ENOG4105EQI Metal Dependent Phosphohydrolase FTW19_09230 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FTW19_09235 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FTW19_09240 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FTW19_09245 ENOG41072GX Peptidase M22 Glycoprotease FTW19_09250 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FTW19_09260 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme FTW19_09265 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FTW19_09275 ENOG4107QUT magnesium and cobalt transport protein CorA FTW19_09345 ENOG4107S1Q Phosphatase FTW19_09385 ENOG4107QXV Phosphate transporter FTW19_09390 ENOG4107GRR phosphate transport regulator FTW19_09400 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FTW19_09405 ENOG4105DJZ UPF0182 protein FTW19_09410 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FTW19_09450 ENOG4105C10 Electron transfer flavoprotein FTW19_09460 ENOG4105DF6 Fe-S oxidoreductase FTW19_09465 ENOG4107Z3H Transcriptional regulator, TetR family FTW19_09475 ENOG4105CHU acetyl-coa acetyltransferase FTW19_09480 ENOG4105C1G acyl-Coa dehydrogenase FTW19_09485 ENOG4107R3N Filamentation induced by cAMP protein fic FTW19_09505 ENOG4105EYH Exonuclease FTW19_09515 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FTW19_09555 ENOG4105CNN ABC, transporter FTW19_09560 ENOG4105C2J ABC transporter FTW19_09565 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FTW19_09570 ENOG4108IUS Transketolase FTW19_09575 ENOG4108HHA Transketolase FTW19_09595 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FTW19_09605 ENOG4105CMG Carbohydrate kinase FTW19_09610 ENOG4105IE8 Alpha-ketoglutarate permease FTW19_09615 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase FTW19_09620 ENOG4105CPC Aldo Keto reductase FTW19_09625 ENOG4105CPQ Dehydrogenase FTW19_09650 ENOG4108KPZ tonB-dependent Receptor FTW19_09715 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) FTW19_09745 ENOG4105DRR Transcriptional regulator, GntR family FTW19_09755 ENOG4105DJB Major Facilitator Superfamily FTW19_09760 ENOG4105CXK mandelate racemase muconate lactonizing FTW19_09790 ENOG4105BZU Histidine kinase FTW19_09800 ENOG4105D05 Receptor FTW19_09805 ENOG4105BZU Histidine kinase FTW19_09815 ENOG4108KPZ tonB-dependent Receptor FTW19_09820 ENOG4105DIA mandelate racemase muconate lactonizing FTW19_09825 ENOG4105EDR glucose galactose transporter FTW19_09835 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FTW19_09845 ENOG4105CHR reductase FTW19_09855 ENOG4105F5H Glycosyl Hydrolase Family 88 FTW19_09870 ENOG4105EX0 alpha-galactosidase FTW19_09875 ENOG4105DDI hemolysin-type calcium-binding region FTW19_09885 ENOG4105ETE Transcriptional regulator (LacI family FTW19_09895 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FTW19_09900 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FTW19_09920 ENOG4105EX0 alpha-galactosidase FTW19_09955 ENOG4105ETE Transcriptional regulator (LacI family FTW19_09975 ENOG4105D5Q Arginine ornithine antiporter FTW19_09980 ENOG4108RVA ribokinase FTW19_09985 ENOG4105F8D glycoside hydrolase family 4 FTW19_10000 ENOG4105ETE Transcriptional regulator (LacI family FTW19_10005 ENOG4106NZI LysR family Transcriptional regulator FTW19_10010 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase FTW19_10015 ENOG4105DJB Major Facilitator Superfamily FTW19_10020 ENOG4105EQX glucarate dehydratase FTW19_10030 ENOG4105CTX dehydratase FTW19_10035 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FTW19_10055 ENOG4108VYJ response regulator receiver protein FTW19_10060 ENOG4108094 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) FTW19_10065 ENOG4108VYJ response regulator receiver protein FTW19_10090 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FTW19_10095 ENOG4105BZU Histidine kinase FTW19_10100 ENOG4105CBS Chea signal transduction histidine kinase FTW19_10105 ENOG4108V3W Chemotaxis protein, CheW FTW19_10110 ENOG4105C8Q Methyl-accepting chemotaxis FTW19_10135 ENOG4105EAA nucleoside FTW19_10140 ENOG4105CIB oxidoreductase Domain protein FTW19_10150 ENOG4105DAG ROK family FTW19_10160 ENOG4105WBN Transcriptional regulator (LacI family FTW19_10165 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FTW19_10170 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FTW19_10175 ENOG4105EBR Carboxylesterase FTW19_10180 ENOG4107WN4 Polygalacturonase FTW19_10215 ENOG4105ETE Transcriptional regulator (LacI family FTW19_10280 ENOG4108ZF3 Phosphatase FTW19_10290 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FTW19_10385 ENOG4108SHN Glycosyl transferase, family 2 FTW19_10395 ENOG4105K64 Glycosyl transferase, family 2 FTW19_10415 ENOG4105E2K Glycosyl transferase (Group 1 FTW19_10430 ENOG4105D3Q Sugar transferase FTW19_10440 ENOG4105DQE DNA ligase FTW19_10445 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FTW19_10450 ENOG4105CAQ asparagine synthetase FTW19_10460 ENOG4107RA4 Glycosyl transferase (Group 1 FTW19_10480 ENOG4105K25 O-Antigen polymerase FTW19_10485 ENOG4108TJN glycosyl transferase group 1 FTW19_10510 ENOG4105C0H protease FTW19_10520 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_10530 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_10560 ENOG4108W5M transcriptional regulator FTW19_10570 ENOG4108NEV two component transcriptional regulator, LytTR family FTW19_10575 ENOG4108HRK Histidine kinase FTW19_10580 ENOG4105CI2 imidazolone-5-propionate hydrolase FTW19_10595 ENOG4105CI2 imidazolone-5-propionate hydrolase FTW19_10615 ENOG4105C4X radical SAM domain protein FTW19_10620 ENOG4105I7I quinohemoprotein amine dehydrogenase gamma subunit FTW19_10630 ENOG4105BZ1 (ABC) transporter FTW19_10635 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FTW19_10645 ENOG4106NZI LysR family Transcriptional regulator FTW19_10650 ENOG4108HRK Histidine kinase FTW19_10655 ENOG4108NEV two component transcriptional regulator, LytTR family FTW19_10670 ENOG4105DQ6 Transposase FTW19_10690 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FTW19_10700 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FTW19_10705 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FTW19_10710 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FTW19_10715 ENOG4105GKE subunit e FTW19_10720 ENOG4107QIZ NADH dehydrogenase FTW19_10725 ENOG4108IEH NADH dehydrogenase subunit g FTW19_10730 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FTW19_10735 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FTW19_10740 ENOG4107UFS subunit j FTW19_10745 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FTW19_10750 ENOG4105D65 subunit l FTW19_10755 ENOG4105C8S subunit m FTW19_10760 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FTW19_10765 ENOG41080XP Cbs domain FTW19_10770 ENOG4105C8Q Methyl-accepting chemotaxis FTW19_10780 ENOG4108KTQ Methyltransferase FTW19_10790 ENOG4105CBS Chea signal transduction histidine kinase FTW19_10795 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FTW19_10810 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FTW19_10835 ENOG4106517 Short-chain dehydrogenase reductase Sdr FTW19_10840 ENOG4105CSP Major Facilitator Superfamily FTW19_10845 ENOG4108KPZ tonB-dependent Receptor FTW19_10865 ENOG4108KPZ tonB-dependent Receptor FTW19_10885 ENOG4106I4J membrane FTW19_10890 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FTW19_10915 ENOG4105ETE Transcriptional regulator (LacI family FTW19_10935 ENOG4105CHR reductase FTW19_10940 ENOG4107RGD Major Facilitator superfamily FTW19_10960 ENOG4108KPZ tonB-dependent Receptor FTW19_10975 ENOG4105BZU Histidine kinase FTW19_10980 ENOG4105ETE Transcriptional regulator (LacI family FTW19_10985 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FTW19_11000 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FTW19_11005 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FTW19_11015 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FTW19_11040 ENOG4105C08 Histidine kinase FTW19_11050 ENOG4105BZ1 (ABC) transporter FTW19_11065 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FTW19_11080 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FTW19_11090 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FTW19_11100 ENOG4105C8T Leucyl-tRNA synthetase FTW19_11110 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FTW19_11125 ENOG4107B2H carbonic anhydrase FTW19_11130 ENOG4105CHH sulfate transporter FTW19_11140 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FTW19_11145 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_11175 ENOG4105BZ1 (ABC) transporter FTW19_11180 ENOG4105CSA Coproporphyrinogen iii oxidase FTW19_11195 ENOG4105XJC Two component transcriptional regulator (Winged helix family FTW19_11200 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FTW19_11215 ENOG4105C8U phosphate abc transporter FTW19_11220 ENOG4105E2Z phosphate ABC transporter (Permease FTW19_11225 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FTW19_11230 ENOG4108UTW Plays a role in the regulation of phosphate uptake FTW19_11240 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FTW19_11250 ENOG4105E4C Lytic transglycosylase catalytic FTW19_11265 ENOG4105D0M Protease HtpX homolog FTW19_11300 ENOG4105DA4 cytochrome c-type biogenesis protein FTW19_11320 ENOG4108V5V Serine Threonine protein kinase FTW19_11330 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FTW19_11335 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FTW19_11350 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FTW19_11355 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FTW19_11360 ENOG4105C6E dna polymerase iii FTW19_11395 ENOG4105C79 DNA protecting protein DprA FTW19_11400 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FTW19_11410 ENOG4105BZU Histidine kinase FTW19_11420 ENOG4105F5H Glycosyl Hydrolase Family 88 FTW19_11430 ENOG4105M3Z response regulator FTW19_11440 ENOG4105E0R Deoxyhypusine synthase FTW19_11460 ENOG4105DBI uridine monophosphokinase FTW19_11485 ENOG4105GR3 Histidine kinase FTW19_11490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FTW19_11515 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FTW19_11525 ENOG4105DFP Integrase FTW19_11595 ENOG4105EXC Acyl-transferase FTW19_11605 ENOG4107RBB ABC transporter, permease FTW19_11615 ENOG4105CZV ABC transporter FTW19_11630 ENOG4108IJF Heavy metal efflux pump, CzcA FTW19_11665 ENOG41080XP Cbs domain FTW19_11675 ENOG4105BZU Histidine kinase FTW19_11680 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FTW19_11685 ENOG4108IAJ Nad-dependent epimerase dehydratase FTW19_11710 ENOG4105JNK Glycosyl transferase (Group 1 FTW19_11720 ENOG4107BJW polysaccharide deacetylase FTW19_11730 ENOG4105CPK Glycosyl transferase (Group 1 FTW19_11770 ENOG4105DAY polysaccharide export protein FTW19_11780 ENOG4105E2K Glycosyl transferase (Group 1 FTW19_11790 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) FTW19_11795 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FTW19_11810 ENOG4107QQG Dehydrogenase FTW19_11815 ENOG4105CND Glycosyl transferase, family 2 FTW19_11825 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FTW19_11830 ENOG4105C1B dTDP-glucose 4-6-dehydratase FTW19_11835 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_11870 ENOG4108KPZ tonB-dependent Receptor FTW19_11880 ENOG4105C5Q Transcriptional regulator FTW19_11885 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FTW19_11895 ENOG4105BZU Histidine kinase FTW19_11925 ENOG41066F8 ROK family FTW19_11935 ENOG4106IQC argininosuccinate lyase FTW19_11940 ENOG4107R7I amino acid FTW19_11975 ENOG4105CA0 peroxidase FTW19_12005 ENOG4108KPZ tonB-dependent Receptor FTW19_12010 ENOG4105BZU Histidine kinase FTW19_12035 ENOG4105D4B ABC, transporter FTW19_12040 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FTW19_12045 ENOG4105C2J ABC transporter FTW19_12050 ENOG4105ETE Transcriptional regulator (LacI family FTW19_12065 ENOG4107RBS Methyltransferase FTW19_12075 ENOG4105KT7 mgtC SapB transporter FTW19_12090 ENOG4108S4H thioesterase Superfamily protein FTW19_12095 ENOG4105D1F ATP-binding protein FTW19_12100 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FTW19_12105 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FTW19_12110 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FTW19_12115 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FTW19_12120 ENOG4105EJQ L-serine dehydratase FTW19_12130 ENOG4105C0P Mg chelatase subunit ChlI FTW19_12140 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FTW19_12150 ENOG4105D9P serine threonine protein kinase FTW19_12165 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FTW19_12170 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FTW19_12175 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FTW19_12180 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FTW19_12185 ENOG4105CEV competence damage-inducible protein FTW19_12195 ENOG4108ZAI phosphatidylglycerophosphatase a FTW19_12210 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FTW19_12220 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FTW19_12235 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FTW19_12245 ENOG4105CAT Cytidine monophosphate kinase FTW19_12250 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FTW19_12255 ENOG4105D07 Signal peptide peptidase, SppA FTW19_12270 ENOG41060IM Heme exporter protein FTW19_12280 ENOG4108Z66 YbaK ebsC protein FTW19_12285 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FTW19_12290 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FTW19_12295 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FTW19_12315 ENOG4108KPZ tonB-dependent Receptor FTW19_12365 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_12375 ENOG4105CHR reductase FTW19_12385 ENOG4105CHR reductase FTW19_12400 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FTW19_12410 ENOG4107SGM protein serine threonine phosphatase FTW19_12415 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FTW19_12440 ENOG4105D8V Glucose sorbosone dehydrogenase FTW19_12455 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FTW19_12470 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FTW19_12485 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FTW19_12495 ENOG4107YIW Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FTW19_12505 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FTW19_12525 ENOG4108TVJ Nitroreductase FTW19_12540 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FTW19_12560 ENOG4105DFM M18 family aminopeptidase FTW19_12595 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FTW19_12600 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FTW19_12605 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FTW19_12610 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FTW19_12620 ENOG4105E50 uracil-dna glycosylase FTW19_12630 ENOG4105GCH Cupin 2 Conserved Barrel Domain Protein FTW19_12655 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FTW19_12665 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FTW19_12680 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FTW19_12685 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_12690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_12720 ENOG4108IJF Heavy metal efflux pump, CzcA FTW19_12730 ENOG4105C3M thioredoxin reductase FTW19_12750 ENOG4108J2P Alpha beta hydrolase fold FTW19_12760 ENOG4105EXG Transcriptional regulator FTW19_12770 ENOG4105BZU Histidine kinase FTW19_12775 ENOG4105EQ2 LysR family Transcriptional regulator FTW19_12780 ENOG4107SET aldo keto reductase FTW19_12785 ENOG4105DQ6 Transposase FTW19_12795 ENOG4105E6M Sulphatase-modifying factor protein FTW19_12800 ENOG4108RVA ribokinase FTW19_12810 ENOG4108KPZ tonB-dependent Receptor FTW19_12820 ENOG4105CQB FAD linked oxidase domain protein FTW19_12825 ENOG4105ERH Fumarylacetoacetate hydrolase FTW19_12830 ENOG4105E39 Enoyl-CoA hydratase FTW19_12855 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FTW19_12880 ENOG4105CWX Alpha-1,2-mannosidase FTW19_12885 ENOG4105CQ7 ATP-dependent helicase FTW19_12895 ENOG4105CHW UPF0052 protein FTW19_12910 ENOG4105CY0 Metallo-Beta-Lactamase FTW19_12915 ENOG4108UTW Plays a role in the regulation of phosphate uptake FTW19_12920 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FTW19_12925 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FTW19_12930 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FTW19_12935 ENOG4107QK9 Beta-lactamase FTW19_12945 ENOG4107RJ1 sodium solute FTW19_12950 ENOG4105RD7 BadF BadG BcrA BcrD FTW19_12955 ENOG4105CE4 GlcNAc 6-P deacetylase FTW19_12970 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FTW19_12975 ENOG4105D2H Uronic isomerase FTW19_12985 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FTW19_12990 ENOG4105CHR reductase FTW19_12995 ENOG4105CHR reductase FTW19_13005 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) FTW19_13010 ENOG4105D7K pfkb domain protein FTW19_13025 ENOG4105D3Q Sugar transferase FTW19_13035 ENOG4105C1P efflux transporter, rnd family, mfp subunit FTW19_13045 ENOG4105FDR Membrane FTW19_13050 ENOG41090KR LysR family transcriptional Regulator FTW19_13060 ENOG4108KPZ tonB-dependent Receptor FTW19_13075 ENOG4105ERH Fumarylacetoacetate hydrolase FTW19_13095 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FTW19_13100 ENOG4105VEQ Cold shock protein FTW19_13105 ENOG4107S2Z UPF0761 membrane protein FTW19_13115 ENOG4105C8Q Methyl-accepting chemotaxis FTW19_13130 ENOG41062BK proline dehydrogenase FTW19_13150 ENOG4105EMN RNA polymerase sigma factor FTW19_13170 ENOG4107R1I NAD-dependent malic enzyme FTW19_13190 ENOG4105C9Q fumarate hydratase class II FTW19_13205 ENOG4105J12 Multidrug resistance protein mdtN FTW19_13210 ENOG4108MI0 Resistance protein FTW19_13215 ENOG4108ZXC Two component transcriptional regulator, luxr family FTW19_13225 ENOG4105BZU Histidine kinase FTW19_13240 ENOG4105FP9 thiamine pyrophosphate FTW19_13245 ENOG4105C26 Dehydrogenase FTW19_13250 ENOG4105BZU Histidine kinase FTW19_13285 ENOG4108ZXC Two component transcriptional regulator, luxr family FTW19_13295 ENOG4105BZU Histidine kinase FTW19_13300 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FTW19_13310 ENOG4105C1G acyl-Coa dehydrogenase FTW19_13315 ENOG4105CEY Amp-dependent synthetase and ligase FTW19_13325 ENOG4105E39 Enoyl-CoA hydratase FTW19_13335 ENOG4105CEP NADH dehydrogenase FTW19_13350 ENOG4105BZ9 Cytochrome C oxidase, subunit I FTW19_13355 ENOG4107QS1 Cytochrome C Oxidase, Subunit III FTW19_13380 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein FTW19_13390 ENOG4105DHJ ABC, transporter FTW19_13430 ENOG4107FQX Alpha-acetolactate decarboxylase FTW19_13435 ENOG4105C7K acetolactate synthase FTW19_13440 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FTW19_13445 ENOG4108KPZ tonB-dependent Receptor FTW19_13450 ENOG4105T16 Transcriptional regulator (AraC family) FTW19_13455 ENOG4105FGE Short-chain dehydrogenase reductase Sdr FTW19_13460 ENOG4105DZG Dehydrogenase FTW19_13470 ENOG4105C01 Dihydroxy-acid dehydratase FTW19_13475 ENOG4105CHR reductase FTW19_13485 ENOG4105DG6 mannose-6-phosphate isomerase FTW19_13490 ENOG4105E98 transcriptional regulator DeoR family FTW19_13500 ENOG4108KPZ tonB-dependent Receptor FTW19_13520 ENOG4105DIA mandelate racemase muconate lactonizing FTW19_13540 ENOG4105BZU Histidine kinase FTW19_13570 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FTW19_13580 ENOG4105EBR Carboxylesterase FTW19_13595 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FTW19_13615 ENOG4105C3M thioredoxin reductase FTW19_13620 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FTW19_13650 ENOG4108IQE Amp-dependent synthetase and ligase FTW19_13660 ENOG4105EEQ Na H antiporter FTW19_13665 ENOG4105C9U ATP-dependent DNA helicase RecQ FTW19_13700 ENOG4107QI1 Mate efflux family protein FTW19_13705 ENOG4107RBB ABC transporter, permease FTW19_13730 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FTW19_13750 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FTW19_13755 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FTW19_13760 ENOG4105E0X reductase FTW19_13765 ENOG4105EST Metal Dependent Phosphohydrolase FTW19_13770 ENOG4105CBG Sulfatase FTW19_13785 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FTW19_13790 ENOG4105CQB FAD linked oxidase domain protein FTW19_13795 ENOG4105CMQ Chloride channel FTW19_13830 ENOG4107RBB ABC transporter, permease FTW19_13835 ENOG4105BZU Histidine kinase FTW19_13850 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_13855 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_13860 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_13890 ENOG4105EGI Transcriptional regulator FTW19_13915 ENOG4105SF0 DinB family FTW19_13920 ENOG4105C4X radical SAM domain protein FTW19_13925 ENOG4105DMQ Methyltransferase FTW19_13945 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FTW19_13950 ENOG4105EPH radical SAM domain protein FTW19_14000 ENOG4105E96 Colicin v production protein FTW19_14005 ENOG4105C8V SAICAR synthetase FTW19_14010 ENOG4107U9T Pfam:Ribonuclease_BN FTW19_14015 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FTW19_14030 ENOG4105E63 Pfam:DUF178 FTW19_14045 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FTW19_14050 ENOG4107QR9 Iron-sulfur cluster binding protein FTW19_14055 ENOG41080R8 Conserved Protein FTW19_14080 ENOG4105BZU Histidine kinase FTW19_14085 ENOG4108YZA Nitrogen regulatory protein pii FTW19_14090 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FTW19_14100 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FTW19_14115 ENOG4105DVY radical SAM domain protein FTW19_14120 ENOG4105DKW ABC transporter FTW19_14135 ENOG4105CH7 arginosuccinase FTW19_14140 ENOG4105DBV ornithine carbamoyltransferase FTW19_14145 ENOG4105C8Y Acetylornithine aminotransferase FTW19_14150 ENOG4105CAS nag kinase FTW19_14155 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FTW19_14160 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FTW19_14215 ENOG4105CJ1 ABC, transporter FTW19_14235 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_14250 ENOG4108IQE Amp-dependent synthetase and ligase FTW19_14260 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FTW19_14270 ENOG4105F27 Major Facilitator FTW19_14275 ENOG4108UGV hypoxanthine phosphoribosyltransferase FTW19_14295 ENOG4105E2D ec 3.2.1.52 FTW19_14310 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FTW19_14320 ENOG4107R7I amino acid FTW19_14330 ENOG4105CUB amino acid FTW19_14340 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FTW19_14345 ENOG4107TEJ This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FTW19_14350 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FTW19_14360 ENOG4108UN4 phage SPO1 DNA polymerase-related protein FTW19_14365 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FTW19_14390 ENOG4105CK5 oxidoreductase FTW19_14420 ENOG4107S5I aldo keto reductase FTW19_14435 ENOG4105C0B DNA polymerase III (alpha subunit) FTW19_14445 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FTW19_14455 ENOG4105CHP RNA polymerase FTW19_14460 ENOG4105GRZ Ycii-related protein FTW19_14480 ENOG4105CPK Glycosyl transferase (Group 1 FTW19_14505 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FTW19_14550 ENOG4108KPZ tonB-dependent Receptor FTW19_14555 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FTW19_14585 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_14590 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_14600 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_14605 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B FTW19_14635 ENOG4105DKQ ROK family FTW19_14650 ENOG4105C0H protease FTW19_14660 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FTW19_14670 ENOG4105C7Z Conserved Protein FTW19_14675 ENOG4105D8X mechanosensitive ion channel FTW19_14685 ENOG4105CPP Dehydrogenase, E1 component FTW19_14710 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FTW19_14720 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FTW19_14730 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FTW19_14740 ENOG4105KCK Peptidoglycan-associated lipoprotein FTW19_14745 ENOG4108DZ7 Serine Threonine protein kinase FTW19_14755 ENOG4105SG9 biopolymer transport protein, ExbD FTW19_14760 ENOG4105E02 MotA TolQ exbB proton channel FTW19_14765 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FTW19_14775 ENOG4105C0B DNA polymerase III (alpha subunit) FTW19_14800 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FTW19_14820 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FTW19_14850 ENOG4108HRK Histidine kinase FTW19_14870 ENOG4105E90 ABC transporter FTW19_14875 ENOG4108IJ8 ABC transporter FTW19_14900 ENOG4105BZA Phosphoglycerate kinase FTW19_14910 ENOG4105CP7 Triose-phosphate isomerase FTW19_14935 ENOG4105C01 Dihydroxy-acid dehydratase FTW19_14945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FTW19_15015 ENOG4108KPZ tonB-dependent Receptor FTW19_15025 ENOG4105C8Q Methyl-accepting chemotaxis FTW19_15040 ENOG4105ESN nucleotide-binding protein FTW19_15045 ENOG4105C9B Cysteine desulfurase FTW19_15050 ENOG4105IH7 synthase FTW19_15080 ENOG4107S2N Type III effector Hrp-dependent FTW19_15085 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FTW19_15090 ENOG4107RJ1 sodium solute FTW19_15095 ENOG4105CNV Aldolase FTW19_15100 ENOG4105C0A alcohol dehydrogenase FTW19_15105 ENOG4107HP6 Transcriptional regulator FTW19_15110 ENOG4108KPZ tonB-dependent Receptor FTW19_15120 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FTW19_15125 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FTW19_15130 ENOG4105FAW cDP-glucose 4,6-dehydratase FTW19_15160 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FTW19_15165 ENOG4105C37 (CBS) domain FTW19_15175 ENOG4107EJC Preprotein translocase subunit SecG FTW19_15185 ENOG4105C5X domain protein FTW19_15195 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FTW19_15200 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FTW19_15210 ENOG4105C9U ATP-dependent DNA helicase RecQ FTW19_15215 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FTW19_15220 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FTW19_15230 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_15250 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FTW19_15255 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FTW19_15260 ENOG4105CPQ Dehydrogenase FTW19_15290 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FTW19_15295 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FTW19_15305 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FTW19_15310 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FTW19_15315 ENOG4105DC7 peptidase M24 FTW19_15350 ENOG4107QXC 3-phosphoshikimate 1-carboxyvinyltransferase FTW19_15365 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FTW19_15385 ENOG4105NZG Ferredoxin FTW19_15395 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FTW19_15410 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FTW19_15460 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FTW19_15465 ENOG4105E4C Lytic transglycosylase catalytic FTW19_15470 ENOG4105EMN RNA polymerase sigma factor FTW19_15490 ENOG4105CCS Glutamate formiminotransferase FTW19_15500 ENOG4105CDY transcriptional regulatory protein FTW19_15505 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FTW19_15510 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FTW19_15515 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FTW19_15530 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FTW19_15535 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FTW19_15570 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FTW19_15575 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FTW19_15580 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FTW19_15605 ENOG4107QW0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FTW19_15615 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FTW19_15625 ENOG4105C8S subunit m FTW19_15630 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FTW19_15635 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_15640 ENOG4105VH4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FTW19_15645 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) FTW19_15660 ENOG4105CRK lysyL-tRNA synthetase FTW19_15665 ENOG4105D48 metallophosphoesterase FTW19_15685 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FTW19_15695 ENOG4108KBE Glycosyl transferase, family 2 FTW19_15700 ENOG4105C0R drug resistance transporter emrb qaca subfamily FTW19_15710 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FTW19_15730 ENOG4107S11 squalene-associated FAD-dependent desaturase FTW19_15745 ENOG4105CPQ Dehydrogenase FTW19_15750 ENOG4105CY3 ABC transporter, permease FTW19_15755 ENOG4105DHJ ABC, transporter FTW19_15760 ENOG4105ECP epimerase FTW19_15780 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FTW19_15785 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FTW19_15800 ENOG4105DTJ flagellar hook-associated protein FTW19_15820 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FTW19_15825 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FTW19_15835 ENOG4105CGA flagellar basal-body rod protein FlgG FTW19_15840 ENOG4105CGA flagellar basal-body rod protein FlgG FTW19_15850 ENOG4105DD5 Flagellar motor switch protein FTW19_15855 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FTW19_15860 ENOG4105D7B Flagellar biosynthesis protein flha FTW19_15865 ENOG4105D00 flagellar biosynthetic protein flhB FTW19_15870 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FTW19_15875 ENOG4105VS8 Flagellar biosynthetic protein fliq FTW19_15880 ENOG4105CN7 Flagellar biosynthetic protein FliP FTW19_15890 ENOG4105X6C Flagellar basal body-associated protein FliL FTW19_15895 ENOG4105BZE flagellar hook protein, FlgE FTW19_15900 ENOG4105W00 Flagellar hook capping protein FTW19_15925 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FTW19_15930 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FTW19_15935 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FTW19_15940 ENOG4108ZC9 flagellar basal-body rod protein flgc FTW19_15945 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FTW19_15950 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_15965 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FTW19_15970 ENOG4105DJY efflux transporter, rnd family, mfp subunit FTW19_15980 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FTW19_15985 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FTW19_15990 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FTW19_15995 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FTW19_16000 ENOG4105C1B dTDP-glucose 4-6-dehydratase FTW19_16005 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FTW19_16015 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FTW19_16030 ENOG4108ZT0 50S ribosomal protein l17 FTW19_16035 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FTW19_16040 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FTW19_16045 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FTW19_16050 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FTW19_16055 ENOG41067V7 50S ribosomal protein L36 FTW19_16060 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FTW19_16070 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FTW19_16080 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FTW19_16085 ENOG410866B 50S ribosomal protein L30 FTW19_16090 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FTW19_16095 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FTW19_16100 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FTW19_16105 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FTW19_16110 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FTW19_16115 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FTW19_16120 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FTW19_16125 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FTW19_16130 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FTW19_16135 ENOG41087MV 50s ribosomal protein l29 FTW19_16140 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FTW19_16145 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FTW19_16150 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FTW19_16155 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FTW19_16160 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FTW19_16165 ENOG410847U One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FTW19_16170 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FTW19_16175 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FTW19_16180 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FTW19_16185 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FTW19_16190 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FTW19_16195 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FTW19_16200 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FTW19_16210 ENOG4105C5Z peptidase FTW19_16220 ENOG4105M7K Involved in the transcription termination process (By similarity) FTW19_16225 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FTW19_16250 ENOG41082GE Binds directly to 16S ribosomal RNA (By similarity) FTW19_16265 ENOG410667J hydrolase FTW19_16270 ENOG4107VXZ Hydrolase FTW19_16300 ENOG4108WQI RNA Polymerase FTW19_16345 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FTW19_16355 ENOG4105DZG Dehydrogenase FTW19_16360 ENOG4105CI2 imidazolone-5-propionate hydrolase FTW19_16365 ENOG4105DND Transcriptional regulator FTW19_16370 ENOG4105CSH Transporter FTW19_16385 ENOG4108KPZ tonB-dependent Receptor FTW19_16390 ENOG4108KPZ tonB-dependent Receptor FTW19_16400 ENOG4105FB2 class II Aldolase FTW19_16415 ENOG4108KPZ tonB-dependent Receptor FTW19_16425 ENOG4105CNT hydrolase family 2 FTW19_16450 ENOG4108KPZ tonB-dependent Receptor FTW19_16455 ENOG410662T chitinase FTW19_16465 ENOG4105D9P serine threonine protein kinase FTW19_16475 ENOG4105K63 Thioredoxin FTW19_16480 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FTW19_16485 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FTW19_16495 ENOG4105E0C molybdate abc transporter FTW19_16500 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FTW19_16505 ENOG4107R4N Cell wall formation (By similarity) FTW19_16510 ENOG4108Y6J UPF0403 protein FTW19_16515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_16540 ENOG4105BZU Histidine kinase FTW19_16550 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FTW19_16570 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_16580 ENOG4105E7U AraC family transcriptional regulator FTW19_16605 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FTW19_16635 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FTW19_16645 ENOG4105FA2 dna polymerase iii FTW19_16655 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FTW19_16670 ENOG4105C7N Xanthine uracil vitamin C permease FTW19_16690 ENOG4105D3Q Sugar transferase FTW19_16695 ENOG4105DHJ ABC, transporter FTW19_16700 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FTW19_16720 ENOG41082JN Transcriptional regulator FTW19_16725 ENOG4105C72 UPF0176 protein FTW19_16730 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_16735 ENOG4105BZU Histidine kinase FTW19_16745 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FTW19_16755 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FTW19_16760 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FTW19_16770 ENOG4105M6F mutator MutT protein FTW19_16785 ENOG4105CJW magnesium transporter FTW19_16790 ENOG4105C9K Endothelin-converting enzyme 1 FTW19_16805 ENOG4108V0P LemA family FTW19_16825 ENOG4105D44 asparaginase FTW19_16830 ENOG4105BZ1 (ABC) transporter FTW19_16855 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FTW19_16865 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FTW19_16880 ENOG41082J7 Rhodanese domain protein FTW19_16900 ENOG4105D9R oxidoreductase FTW19_16905 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FTW19_16910 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FTW19_16925 ENOG4108IAJ Nad-dependent epimerase dehydratase FTW19_16930 ENOG4105C6Y Udp-glucose 6-dehydrogenase FTW19_16935 ENOG4107YJ4 chain length determinant protein FTW19_16960 ENOG4106WTF Glycosyl transferase, family 2 FTW19_17005 ENOG4105C83 adenylosuccinate lyase FTW19_17025 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FTW19_17060 ENOG4108KPZ tonB-dependent Receptor FTW19_17065 ENOG4107HQ7 repeat protein FTW19_17070 ENOG4107QNK )-transporter FTW19_17095 ENOG4105C0H protease FTW19_17120 ENOG4107STQ Multicopper oxidase FTW19_17140 ENOG4105CKK Glycosyl transferase, family 2 FTW19_17255 ENOG4107QWP ABC-2 type transporter FTW19_17260 ENOG4105CJ1 ABC, transporter FTW19_17280 ENOG4105CXK mandelate racemase muconate lactonizing FTW19_17305 ENOG4105DZG Dehydrogenase FTW19_17315 ENOG4105K78 MarR family Transcriptional regulator FTW19_17320 ENOG4105BZU Histidine kinase FTW19_17345 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FTW19_17370 ENOG4105DC7 peptidase M24 FTW19_17380 ENOG4105CIR epoxide hydrolase FTW19_17385 ENOG4108XFH Transcriptional regulator FTW19_17400 ENOG4108X0B nad(p)h dehydrogenase (quinone) FTW19_17415 ENOG4105CI2 imidazolone-5-propionate hydrolase FTW19_17435 ENOG4105EMU Dehydrogenase FTW19_17440 ENOG4105CF7 AraC family transcriptional regulator FTW19_17450 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FTW19_17455 ENOG4108XHQ (2Fe-2S)-binding domain protein FTW19_17465 ENOG4107SET aldo keto reductase FTW19_17490 ENOG4107QN1 sodium solute FTW19_17495 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FTW19_17500 ENOG4105CE4 GlcNAc 6-P deacetylase FTW19_17540 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FTW19_17555 ENOG4105CPK Glycosyl transferase (Group 1 FTW19_17590 ENOG4105HTX biosynthesis protein FTW19_17600 ENOG4108QV3 biosynthesis protein FTW19_17615 ENOG4105CPK Glycosyl transferase (Group 1 FTW19_17630 ENOG4107RA4 Glycosyl transferase (Group 1 FTW19_17635 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_17640 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_17650 ENOG4108IAJ Nad-dependent epimerase dehydratase FTW19_17655 ENOG4108SHN Glycosyl transferase, family 2 FTW19_17815 ENOG4108M3R transcriptional activator CadC FTW19_17840 ENOG4108I0Y (ABC) transporter FTW19_17845 ENOG4108UJV acyl-CoA thioesterase i FTW19_17855 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FTW19_17860 ENOG4105EUJ GTP cyclohydrolase i FTW19_17875 ENOG4105CXK mandelate racemase muconate lactonizing FTW19_17885 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FTW19_17900 ENOG4105CG3 alpha amylase, catalytic region FTW19_17910 ENOG4105CE1 Ferrous iron transport protein b FTW19_17920 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FTW19_17925 ENOG4105DX0 Hemolysin A FTW19_17965 ENOG4105C0R drug resistance transporter emrb qaca subfamily FTW19_17980 ENOG4108RWN rrna methyltransferase FTW19_17985 ENOG4105D1H recombination factor protein RarA FTW19_17995 ENOG4105E5K Alpha-amylase FTW19_18020 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FTW19_18030 ENOG4105CHR reductase FTW19_18040 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FTW19_18045 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FTW19_18080 ENOG4106N3A copper homeostasis protein cutc FTW19_18085 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FTW19_18090 ENOG4105E98 transcriptional regulator DeoR family FTW19_18100 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FTW19_18105 ENOG4105C1V Peptidase, M16 FTW19_18110 ENOG4108VAU general secretion pathway protein G FTW19_18160 ENOG4105CWX Alpha-1,2-mannosidase FTW19_18170 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FTW19_18175 ENOG41081QV Universal stress protein FTW19_18195 ENOG4105C89 phosphohexose isomerase FTW19_18200 ENOG4105I4A GCN5-related N-acetyltransferase FTW19_18205 ENOG4105F2Z 3-oxoadipate enol-lactonase FTW19_18210 ENOG4107HP6 Transcriptional regulator FTW19_18220 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FTW19_18225 ENOG4107SJI Dehydrogenase FTW19_18240 ENOG4108M8S permease YjgP YjgQ family protein FTW19_18250 ENOG4105BZ1 (ABC) transporter FTW19_18265 ENOG4105I03 Flagellin FTW19_18275 ENOG4105E14 MotA TolQ exbB proton channel FTW19_18280 ENOG4106VK6 Flagellar motor protein FTW19_18285 ENOG4106WTF Glycosyl transferase, family 2 FTW19_18290 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FTW19_18300 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FTW19_18310 ENOG4105E33 succinate dehydrogenase FTW19_18340 ENOG4108IGT Dipeptidase FTW19_18360 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FTW19_18365 ENOG4105DWT malate dehydrogenase (quinone) FTW19_18370 ENOG4108HMX isocitrate dehydrogenase (NADP) FTW19_18375 ENOG4105C5F glutamine synthetase FTW19_18405 ENOG4108Z6B deaminase FTW19_18410 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FTW19_18425 ENOG4105K4P CoA-binding domain protein FTW19_18440 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FTW19_18455 ENOG4105E8R UPF0173 metal-dependent hydrolase FTW19_18475 ENOG4105DTQ mandelate racemase muconate lactonizing FTW19_18485 ENOG4105DXN mazG family FTW19_18500 ENOG41090EK ompa motb domain protein FTW19_18505 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FTW19_18510 ENOG4107S1Q Phosphatase FTW19_18520 ENOG4105CGZ zinc metallopeptidase FTW19_18530 ENOG4105CCF Lysine exporter protein (Lyse ygga) FTW19_18550 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FTW19_18585 ENOG4105E98 transcriptional regulator DeoR family FTW19_18595 ENOG4108KPW sugar kinase FTW19_18605 ENOG4107QNK )-transporter FTW19_18615 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FTW19_18630 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FTW19_18645 ENOG4105CUB amino acid FTW19_18650 ENOG4105CBG Sulfatase FTW19_18660 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FTW19_18665 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FTW19_18675 ENOG4105DZG Dehydrogenase FTW19_18690 ENOG4105BZU Histidine kinase FTW19_18705 ENOG4105EMN RNA polymerase sigma factor FTW19_18730 ENOG4105CTZ aminopeptidase c FTW19_18740 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FTW19_18755 ENOG4105RAK Histidine kinase FTW19_18800 ENOG4105DFU Cell wall formation (By similarity) FTW19_18805 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FTW19_18810 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FTW19_18825 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) FTW19_18835 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FTW19_18845 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FTW19_18865 ENOG4108JQC penicillin-binding protein 1A FTW19_18880 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) FTW19_18910 ENOG4108KPZ tonB-dependent Receptor FTW19_18930 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FTW19_18965 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_18975 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FTW19_18980 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FTW19_18990 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FTW19_19005 ENOG4105CEN a g-specific adenine glycosylase FTW19_19020 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FTW19_19025 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FTW19_19030 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FTW19_19040 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FTW19_19050 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FTW19_19065 ENOG4108DIF synthase (EC 4.2.1.75) FTW19_19070 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FTW19_19075 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FTW19_19085 ENOG4107QI1 Mate efflux family protein FTW19_19090 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FTW19_19095 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FTW19_19100 ENOG4108J59 Extracellular solute-binding protein, family 5 FTW19_19145 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FTW19_19155 ENOG4108VAU general secretion pathway protein G FTW19_19170 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FTW19_19175 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FTW19_19180 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_19185 ENOG4105C75 arginyL-tRNA synthetase FTW19_19210 ENOG4105EJG cellulose synthase FTW19_19215 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FTW19_19240 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FTW19_19245 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FTW19_19250 ENOG4105DKP glycosyl transferase, family 9 FTW19_19265 ENOG4107YTP response regulator receiver protein FTW19_19285 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FTW19_19300 ENOG4105C5H ABC transporter FTW19_19310 ENOG4105VB6 UPF0109 protein FTW19_19315 ENOG41080ND 30s ribosomal protein S16 FTW19_19330 ENOG4105BZU Histidine kinase FTW19_19350 ENOG4107S52 alpha-2-macroglobulin domain protein FTW19_19355 ENOG4108QJJ Protein of unknown function (DUF1175) FTW19_19360 ENOG4108KPZ tonB-dependent Receptor FTW19_19370 ENOG4105E2V Glycosyltransferase 36 FTW19_19390 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) FTW19_19395 ENOG4105CIH Imidazole acetol-phosphate transaminase FTW19_19405 ENOG4108FN7 Aldo keto reductase FTW19_19410 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FTW19_19415 ENOG4105K8N protein family UPF0079, ATPase FTW19_19435 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FTW19_19440 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FTW19_19445 ENOG4108APS Essential cell division protein (By similarity) FTW19_19450 ENOG4105DFU Cell wall formation (By similarity) FTW19_19460 ENOG4105CIH Imidazole acetol-phosphate transaminase FTW19_19475 ENOG41082QS Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FTW19_19480 ENOG4107XI1 DHH family FTW19_19485 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FTW19_19500 ENOG4105DC7 peptidase M24 FTW19_19525 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FTW19_19535 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FTW19_19540 ENOG4105CHV Transcription elongation factor NusA FTW19_19545 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FTW19_19555 ENOG4107RFA Glycyl-tRNA synthetase beta subunit FTW19_19560 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FTW19_19580 ENOG410847H Involved in DNA repair and RecF pathway recombination (By similarity) FTW19_19605 ENOG4108ZAF Molybdopterin FTW19_19620 ENOG4105WH1 Two component transcriptional regulator luxr family FTW19_19625 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FTW19_19650 ENOG4108J08 Csbd family FTW19_19670 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FTW19_19680 ENOG4105D06 uba thif-type nad fad binding protein FTW19_19685 ENOG4105EMN RNA polymerase sigma factor FTW19_19695 ENOG4105CRQ synthase (Component I) FTW19_19705 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FTW19_19710 ENOG4108SJC Membrane FTW19_19720 ENOG4108UUM single-stranded DNA-binding protein FTW19_19730 ENOG4106WTF Glycosyl transferase, family 2 FTW19_19735 ENOG4105CHR reductase FTW19_19740 ENOG410829K Lysine exporter protein (Lyse ygga) FTW19_19760 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FTW19_19765 ENOG4105CQB FAD linked oxidase domain protein FTW19_19770 ENOG4105CQB FAD linked oxidase domain protein FTW19_19775 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FTW19_19785 ENOG4107QP3 malate synthase g FTW19_19805 ENOG4108UN4 phage SPO1 DNA polymerase-related protein FTW19_19815 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FTW19_19820 ENOG4105DSJ YicC domain protein FTW19_19825 ENOG4105BZ1 (ABC) transporter FTW19_19830 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FTW19_19840 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FTW19_19845 ENOG4108IUZ ABC transporter FTW19_19860 ENOG4105BZU Histidine kinase FTW19_19865 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FTW19_19885 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) FTW19_19955 ENOG4105VQD rieske 2fe-2S domain-containing protein FTW19_19990 ENOG4105WH1 Two component transcriptional regulator luxr family FTW19_20000 ENOG4108KPJ rna polymerase sigma factor FTW19_20025 ENOG4108S01 response regulator FTW19_20030 ENOG4105BZU Histidine kinase FTW19_20040 ENOG4108M15 ABC transporter FTW19_20065 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) FTW19_20075 ENOG4108Z9Z response to DNA damage stimulus FTW19_20095 ENOG4105FDP GntR family transcriptional regulator FTW19_20110 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase FTW19_20130 ENOG4108NVM synthesis repressor PhaR FTW19_20145 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FTW19_20150 ENOG4105CHR reductase FTW19_20155 ENOG4105CHU acetyl-coa acetyltransferase FTW19_20160 ENOG4105CHR reductase FTW19_20165 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FTW19_20170 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FTW19_20175 ENOG4105CI2 imidazolone-5-propionate hydrolase FTW19_20180 ENOG4105CGP Urocanate hydratase FTW19_20185 ENOG4105C84 Histidine ammonia-lyase FTW19_20190 ENOG4105EW9 transcriptional regulator AsnC family FTW19_20200 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FTW19_20210 ENOG4108HRK Histidine kinase FTW19_20215 ENOG4108NEV two component transcriptional regulator, LytTR family FTW19_20260 ENOG4105BZU Histidine kinase FTW19_20265 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FTW19_20270 ENOG4108K5P (LipO)protein FTW19_20285 ENOG4105C8F Beta-lactamase domain protein FTW19_20315 ENOG4105E3W Two component transcriptional regulator (Winged helix family FTW19_20340 ENOG4107RT4 flavin reductase domain protein FTW19_20360 ENOG4105DDQ anthranilate synthase FTW19_20380 ENOG4108FN7 Aldo keto reductase FTW19_20385 ENOG4105VEQ Cold shock protein FTW19_20420 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FTW19_20430 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FTW19_20435 ENOG4105DTD Dehydrogenase FTW19_20440 ENOG4105KNI merR family transcriptional Regulator FTW19_20460 ENOG4105CEC DNA methylase N-4 N-6 FTW19_20465 ENOG4108ZF3 Phosphatase FTW19_20475 ENOG4105Q2H domain protein FTW19_20485 ENOG4107ZXI Rhomboid family FTW19_20505 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FTW19_20550 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FTW19_20555 ENOG41087NY 50S ribosomal protein L33 FTW19_20570 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FTW19_20575 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FTW19_20580 ENOG4105E1F short-chain dehydrogenase reductase FTW19_20585 ENOG4108IXY short-chain dehydrogenase reductase FTW19_20590 ENOG4107Z3H Transcriptional regulator, TetR family FTW19_20595 ENOG4105I6B RNA polymerase FTW19_20620 ENOG4107R7Y intracellular protease Pfpi family FTW19_20625 ENOG4105CEP NADH dehydrogenase FTW19_20635 ENOG4105C3M thioredoxin reductase FTW19_20660 ENOG4105DFA alanine racemase domain protein FTW19_20665 ENOG4105VZ9 UPF0235 protein FTW19_20670 ENOG4105EAQ (twin-arginine translocation) pathway signal FTW19_20680 ENOG4105CK7 Sodium proline symporter FTW19_20695 ENOG4105KME endoribonuclease L-psp FTW19_20710 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) FTW19_20715 ENOG4107QRT dEAD DEAH box helicase FTW19_20720 ENOG4105KG3 cytidine deaminase FTW19_20725 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FTW19_20730 ENOG4105D9N nucleoside FTW19_20750 ENOG4105DEN Luciferase family FTW19_20760 ENOG4107YRI Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FTW19_20765 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FTW19_20770 ENOG4105ERG peptidase m48, ste24p FTW19_20780 ENOG4105DKQ ROK family FTW19_20785 ENOG4107T5V SNARE associated Golgi FTW19_20795 ENOG4105CHR reductase FTW19_20800 ENOG41066DG (EAL) domain protein FTW19_20815 ENOG4105D3R alkyl hydroperoxide reductase FTW19_20845 ENOG4105EMU Dehydrogenase FTW19_20855 ENOG4105CHR reductase FTW19_20865 ENOG4105JAB phenazine biosynthesis protein, phzf family FTW19_20890 ENOG4108Z0R Transferase FTW19_20895 ENOG4105DQ4 alcohol dehydrogenase FTW19_20900 ENOG4105W4W Transcriptional regulator FTW19_20905 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FTW19_20910 ENOG4105KVH Transcriptional regulator FTW19_20935 ENOG4107JTW chlorite dismutase FTW19_20960 ENOG4105C28 cystathionine FTW19_20970 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FTW19_20985 ENOG4105ETE Transcriptional regulator (LacI family FTW19_21025 ENOG4108KPZ tonB-dependent Receptor FTW19_21040 ENOG4108KPZ tonB-dependent Receptor FTW19_21045 ENOG4105EE1 crotonyl-CoA reductase FTW19_21090 ENOG4107YZX Universal stress protein FTW19_21095 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FTW19_21105 ENOG4105BZU Histidine kinase FTW19_21110 ENOG4108UXN response regulator FTW19_21115 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_21130 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FTW19_21150 ENOG4107SCA Formamidase (EC 3.5.1.49) FTW19_21155 ENOG4108KPZ tonB-dependent Receptor FTW19_21160 ENOG4105CI2 imidazolone-5-propionate hydrolase FTW19_21170 ENOG4105ENE Histidine kinase FTW19_21180 ENOG4105C26 Dehydrogenase FTW19_21185 ENOG4108KPZ tonB-dependent Receptor FTW19_21200 ENOG4105CV1 Transketolase (EC 2.2.1.1) FTW19_21215 ENOG41069M3 Transcriptional regulator FTW19_21225 ENOG4105CHR reductase FTW19_21230 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FTW19_21240 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_21245 ENOG4105DZG Dehydrogenase FTW19_21285 ENOG4108KPZ tonB-dependent Receptor FTW19_21300 ENOG4105DPW Major facilitator superfamily MFS_1 FTW19_21305 ENOG4105CNT hydrolase family 2 FTW19_21310 ENOG4105ETE Transcriptional regulator (LacI family FTW19_21345 ENOG4108478 ec 3.2.1.18 FTW19_21400 ENOG4105CHR reductase FTW19_21405 ENOG4105CPQ Dehydrogenase FTW19_21410 ENOG4105CXY transporter FTW19_21415 ENOG4107YCY Transcriptional regulator FTW19_21420 ENOG4105WH1 Two component transcriptional regulator luxr family FTW19_21475 ENOG4105CE4 GlcNAc 6-P deacetylase FTW19_21490 ENOG4105CEI nitrite reductase FTW19_21505 ENOG4105CN9 Peptidase m42 family protein FTW19_21530 ENOG4105GR3 Histidine kinase FTW19_21535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FTW19_21555 ENOG4105CHR reductase FTW19_21590 ENOG41064MX Tetr family transcriptional regulator FTW19_21615 ENOG4105DVE abc transporter atp-binding protein FTW19_21625 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FTW19_21635 ENOG4105E2K Glycosyl transferase (Group 1 FTW19_21675 ENOG4105C8Q Methyl-accepting chemotaxis FTW19_21695 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FTW19_21710 ENOG4107YCR Transcriptional regulator, ARSR family FTW19_21750 ENOG4105E18 UPF0276 protein FTW19_21770 ENOG4105EMN RNA polymerase sigma factor FTW19_21785 ENOG4107R6D beta-lactam binding protein AmpH FTW19_21790 ENOG4105BZU Histidine kinase FTW19_21815 ENOG4105BZU Histidine kinase FTW19_21820 ENOG4105EMN RNA polymerase sigma factor FTW19_21835 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FTW19_21900 ENOG4108JJA ABC, transporter FTW19_21920 ENOG4108KQ5 Integrase catalytic subunit FTW19_21930 ENOG4105BZU Histidine kinase FTW19_21935 ENOG4108ZXC Two component transcriptional regulator, luxr family FTW19_21940 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FTW19_21950 ENOG4105ENT Efflux transporter rnd family, mfp subunit FTW19_21965 ENOG4107SET aldo keto reductase FTW19_21995 ENOG4108VX5 3-methyladenine DNA glycosylase FTW19_22000 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FTW19_22015 ENOG4105BZU Histidine kinase FTW19_22020 ENOG4105EU0 Major facilitator Superfamily FTW19_22030 ENOG4105HY2 Glycosidase related protein FTW19_22035 ENOG4105E2K Glycosyl transferase (Group 1 FTW19_22070 ENOG4105BZU Histidine kinase FTW19_22080 ENOG4105CDV Ompa motb domain protein FTW19_22090 ENOG4107QX8 SPFH domain, Band 7 family protein FTW19_22105 ENOG4105EA8 2-Nitropropane dioxygenase FTW19_22115 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FTW19_22120 ENOG4107RSM transcriptional regulator FTW19_22150 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FTW19_22155 ENOG4108IG5 Transcriptional regulator FTW19_22170 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_22190 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FTW19_22230 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FTW19_22245 ENOG4108M8W Monooxygenase FTW19_22250 ENOG4108RPX mosc domain containing protein FTW19_22255 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_22280 ENOG4105BZU Histidine kinase FTW19_22285 ENOG4105E0K tonB-dependent siderophore receptor FTW19_22310 ENOG4108XHQ (2Fe-2S)-binding domain protein FTW19_22365 ENOG4108RPX mosc domain containing protein FTW19_22375 ENOG4105D9R oxidoreductase FTW19_22395 ENOG4105EQK -acetyltransferase FTW19_22415 ENOG4106WTF Glycosyl transferase, family 2 FTW19_22450 ENOG4108KPZ tonB-dependent Receptor FTW19_22460 ENOG4105CHR reductase FTW19_22490 ENOG4105C2M dna polymerase I FTW19_22500 ENOG4107RBB ABC transporter, permease FTW19_22530 ENOG4105DTD Dehydrogenase FTW19_22535 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_22570 ENOG4105CHJ isochorismatase hydrolase FTW19_22575 ENOG4105CPN adenine deaminase FTW19_22590 ENOG4105C3M thioredoxin reductase FTW19_22595 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FTW19_22600 ENOG4105C3F Signal peptidase i FTW19_22625 ENOG4105CY0 Metallo-Beta-Lactamase FTW19_22630 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FTW19_22640 ENOG4105CHR reductase FTW19_22645 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FTW19_22650 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FTW19_22655 ENOG4105CBN LysR family transcriptional regulator FTW19_22670 ENOG4105CF7 AraC family transcriptional regulator FTW19_22695 ENOG4107SET aldo keto reductase FTW19_22715 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FTW19_22730 ENOG4107RBB ABC transporter, permease FTW19_22735 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FTW19_22770 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FTW19_22775 ENOG4105E7U AraC family transcriptional regulator FTW19_22820 ENOG4105DQ4 alcohol dehydrogenase FTW19_22855 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FTW19_22895 ENOG4105II7 pyrroline-5-carboxylate reductase FTW19_22900 ENOG4108KQ5 Integrase catalytic subunit FTW19_22930 ENOG4108IG5 Transcriptional regulator FTW19_22940 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FTW19_22945 ENOG4105Y49 secretion protein, HlyD family FTW19_22960 ENOG41060IM Heme exporter protein FTW19_22965 ENOG4108W5M transcriptional regulator FTW19_22975 ENOG4105CHP RNA polymerase FTW19_23010 ENOG4105DUM transcriptional regulator, lysR family FTW19_23015 ENOG4105CMQ Chloride channel FTW19_23035 ENOG4108XTP Transcriptional regulator FTW19_23075 ENOG41083PU Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FTW19_23100 ENOG4108KQ5 Integrase catalytic subunit FTW19_23115 ENOG4108KQ5 Integrase catalytic subunit FTW19_23145 ENOG4105C3R Methionine synthase FTW19_23150 ENOG4105C3R Methionine synthase FTW19_23155 ENOG4108KQ5 Integrase catalytic subunit FTW19_23265 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FTW19_23290 ENOG4108NEV two component transcriptional regulator, LytTR family FTW19_23295 ENOG4108KQ5 Integrase catalytic subunit FTW19_23315 ENOG4108KQ5 Integrase catalytic subunit FTW19_23320 ENOG4105BZU Histidine kinase FTW19_23325 ENOG4108KQ5 Integrase catalytic subunit FTW19_23330 ENOG4108XHQ (2Fe-2S)-binding domain protein FTW19_23350 ENOG4108KQ5 Integrase catalytic subunit FTW19_23365 ENOG4108KQ5 Integrase catalytic subunit FTW19_23395 ENOG4105DJY efflux transporter, rnd family, mfp subunit FTW19_23405 ENOG4105C7W Xanthine dehydrogenase FTW19_23460 ENOG4105GRZ Ycii-related protein FTW19_23495 ENOG4105CDH Citrulline--aspartate ligase FTW19_23505 ENOG4105FDF Could be involved in DNA repair (By similarity) FTW19_23510 ENOG4107RBB ABC transporter, permease FTW19_23515 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_23525 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_23535 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FTW19_23600 ENOG4105EX0 alpha-galactosidase FTW19_23605 ENOG4108KPZ tonB-dependent Receptor FTW19_23615 ENOG4105CC0 LysR family Transcriptional regulator FTW19_23620 ENOG4105CHJ isochorismatase hydrolase FTW19_23655 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FTW19_23665 ENOG4108HKT sucrose-6-phosphate hydrolase FTW19_23680 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_23690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FTW19_23700 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FTW19_23720 ENOG4105C3M thioredoxin reductase FTW19_23725 ENOG4108M3R transcriptional activator CadC FTW19_23730 ENOG4105D3R alkyl hydroperoxide reductase FTW19_23735 ENOG4107TPS domain protein FTW19_23760 ENOG4105C1P efflux transporter, rnd family, mfp subunit FTW19_23765 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FTW19_23780 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FTW19_23810 ENOG4105CJR Integral membrane protein (MviN FTW19_23820 ENOG4105EBR Carboxylesterase FTW19_23825 ENOG4105CWX Alpha-1,2-mannosidase FTW19_23850 ENOG4105CHR reductase FTW19_23860 ENOG4105E0F Histidine kinase FTW19_23865 ENOG4105E3W Two component transcriptional regulator (Winged helix family FTW19_23895 ENOG4108KPZ tonB-dependent Receptor FTW19_23905 ENOG4105ETX regulatoR FTW19_23910 ENOG4105GR3 Histidine kinase FTW19_23985 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FTW19_24000 ENOG4105EXC Acyl-transferase FTW19_24020 ENOG4105J12 Multidrug resistance protein mdtN FTW19_24050 ENOG4105C26 Dehydrogenase FTW19_24060 ENOG4105DG6 mannose-6-phosphate isomerase FTW19_24070 ENOG4108IG5 Transcriptional regulator FTW19_24080 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FTW19_24085 ENOG4107B2H carbonic anhydrase FTW19_24090 ENOG4105FFC UPF0187 protein FTW19_24095 ENOG4105C19 ABC transporter FTW19_24105 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FTW19_24125 ENOG4105C9K Endothelin-converting enzyme 1 FTW19_24150 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FTW19_24155 ENOG4105C1B dTDP-glucose 4-6-dehydratase FTW19_24190 ENOG4105CM2 brancheD-chain amino acid aminotransferase FTW19_24205 ENOG4105FDF Could be involved in DNA repair (By similarity) FTW19_24215 ENOG4105DQE DNA ligase FTW19_24220 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FTW19_24225 ENOG4105C9B Cysteine desulfurase FTW19_24230 ENOG4105DPW Major facilitator superfamily MFS_1 FTW19_24235 ENOG41073TP transcriptional regulator FTW19_24245 ENOG4105F8V Hydrolase, tatD family FTW19_24250 ENOG4108VPT UPF0234 protein FTW19_24260 ENOG4105EAH synthase FTW19_24265 ENOG4105C25 Primosomal protein n' FTW19_24275 ENOG4105K70 DNA-binding protein FTW19_24280 ENOG4105DHP deoxycytidine triphosphate deaminase FTW19_24295 ENOG4105BZU Histidine kinase FTW19_24300 ENOG4105D1S lipid A biosynthesis FTW19_24305 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FTW19_24330 ENOG4105E66 phosphoriboisomerase A FTW19_24340 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FTW19_24375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FTW19_24380 ENOG4108Z6B deaminase FTW19_24390 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FTW19_24395 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FTW19_24410 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FTW19_24420 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FTW19_24425 ENOG4105C2X Arabinose 5-phosphate isomerase FTW19_24435 ENOG41084GC stage II sporulation protein FTW19_24440 ENOG4107QP0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FTW19_24445 ENOG4105BZ4 penicillin-binding protein FTW19_24450 ENOG4105EXC Acyl-transferase FTW19_24460 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FTW19_24470 ENOG41089W5 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FTW19_24485 ENOG4105NBR Pectinesterase FTW19_24505 ENOG4105C9F isomerase FTW19_24530 ENOG4108KQ5 Integrase catalytic subunit FTW19_24550 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FTW19_24555 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_24570 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FTW19_24600 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FTW19_24610 ENOG4105CFG Acts as a chaperone (By similarity) FTW19_24625 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FTW19_24630 ENOG4108NWD Cytochrome FTW19_24660 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FTW19_24680 ENOG4107RBB ABC transporter, permease FTW19_24710 ENOG4105C0R drug resistance transporter emrb qaca subfamily FTW19_24720 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FTW19_24725 ENOG4105ES4 Nitrilase FTW19_24740 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FTW19_24760 ENOG4107SGM protein serine threonine phosphatase FTW19_24775 ENOG4105EQR Transposase IS116 IS110 IS902 FTW19_24785 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FTW19_24790 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FTW19_24795 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FTW19_24800 ENOG4105CIH Imidazole acetol-phosphate transaminase FTW19_24805 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FTW19_24815 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FTW19_24820 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FTW19_24825 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FTW19_24830 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FTW19_24855 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FTW19_24860 ENOG4105KNE Phosphatidate cytidylyltransferase FTW19_24865 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FTW19_24870 ENOG4105DZP Membrane-associated zinc metalloprotease FTW19_24880 ENOG4107TUY Histidine kinase FTW19_24930 ENOG4105EQ0 Major Facilitator superfamily FTW19_24970 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FTW19_24975 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FTW19_24980 ENOG4105BZU Histidine kinase FTW19_25000 ENOG4108004 Modulates RecA activity (By similarity) FTW19_25005 ENOG4105C3F Signal peptidase i FTW19_25020 ENOG4105C2N RNA methyltransferase TrmH family group 3 FTW19_25040 ENOG4105DY9 regulatoR FTW19_25060 ENOG4105EJ9 Membrane FTW19_25065 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FTW19_25075 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FTW19_25080 ENOG4105VJV 50s ribosomal protein L35 FTW19_25085 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FTW19_25100 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FTW19_25105 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FTW19_25115 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FTW19_25140 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FTW19_25145 ENOG4105C5H ABC transporter FTW19_25165 ENOG4105CI3 gtp-binding protein typa FTW19_25195 ENOG4105CG3 alpha amylase, catalytic region FTW19_25235 ENOG4105BZU Histidine kinase FTW19_25270 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FTW19_25275 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FTW19_25280 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FTW19_25295 ENOG4105DZ6 Band 7 protein FTW19_25320 ENOG4107SGM protein serine threonine phosphatase FTW19_25325 ENOG4105CXN decarboxylase FTW19_25330 ENOG4105ERH Fumarylacetoacetate hydrolase FTW19_25345 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C FTW19_25350 ENOG4105C0R drug resistance transporter emrb qaca subfamily FTW19_25365 ENOG4105CPC Aldo Keto reductase FTW19_25390 ENOG4105C08 Histidine kinase FTW19_25405 ENOG4107T0X DNA ligase FTW19_25410 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FTW19_25415 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FTW19_25420 ENOG4105BZU Histidine kinase FTW19_25425 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FTW19_25440 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FTW19_25455 ENOG4105BZU Histidine kinase FTW19_25485 ENOG4107RH7 Nicotinate phosphoribosyltransferase FTW19_25490 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FTW19_25500 ENOG4105JUU One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FTW19_25515 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FTW19_25520 ENOG4105CXT aspartate transcarbamylase FTW19_25525 ENOG4105CD3 dihydroorotase FTW19_25545 ENOG4105C3G gtp-binding protein FTW19_25550 ENOG41061MV Arylsulfatase FTW19_25555 ENOG4105CHM Aminotransferase FTW19_25565 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FTW19_25575 ENOG4105JQZ Methyltransferase FTW19_25600 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FTW19_25605 ENOG4105DR5 peptidase FTW19_25620 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FTW19_25630 ENOG4106FVC RNA methyltransferase FTW19_25635 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)