locus-tag	class	description
AciPR4_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AciPR4_0004	COG1193	negative regulation of DNA recombination
AciPR4_0005	COG0667	Aldo Keto reductase
AciPR4_0007	COG0113	porphobilinogen synthase activity
AciPR4_0011	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AciPR4_0012	COG1733	regulation of RNA biosynthetic process
AciPR4_0017	COG0702	epimerase
AciPR4_0018	COG1733	regulation of RNA biosynthetic process
AciPR4_0025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AciPR4_0026	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AciPR4_0028	COG0656	L-ascorbic acid biosynthetic process
AciPR4_0031	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AciPR4_0033	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AciPR4_0039	COG2140	Oxalate decarboxylase
AciPR4_0040	COG0386	Belongs to the glutathione peroxidase family
AciPR4_0041	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AciPR4_0044	COG0667	Aldo Keto reductase
AciPR4_0047	COG0577	efflux transmembrane transporter activity
AciPR4_0048	COG0577	efflux transmembrane transporter activity
AciPR4_0057	COG0583	DNA-binding transcription factor activity
AciPR4_0063	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AciPR4_0069	COG1082	Xylose isomerase domain protein TIM barrel
AciPR4_0073	COG0321	lipoyl(octanoyl) transferase activity
AciPR4_0074	COG0508	dehydrogenase complex catalyzes the overall conversion of
AciPR4_0079	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AciPR4_0080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AciPR4_0081	COG2826	transposase and inactivated derivatives, IS30 family
AciPR4_0105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AciPR4_0107	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_0110	COG2197	response regulator
AciPR4_0129	COG0582	viral genome integration into host DNA
AciPR4_0135	COG0316	Belongs to the HesB IscA family
AciPR4_0136	COG0577	efflux transmembrane transporter activity
AciPR4_0136	COG1136	(ABC) transporter
AciPR4_0137	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AciPR4_0139	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AciPR4_0141	COG0443	Heat shock 70 kDa protein
AciPR4_0143	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AciPR4_0144	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AciPR4_0147	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AciPR4_0151	COG2814	Major facilitator Superfamily
AciPR4_0154	COG1764	response to oxidative stress
AciPR4_0158	COG0612	Peptidase, M16
AciPR4_0167	COG2081	HI0933 family
AciPR4_0176	COG4302	ethanolamine ammonia-lyase activity
AciPR4_0177	COG4303	Ethanolamine ammonia lyase large subunit
AciPR4_0180	COG3511	phospholipase C
AciPR4_0182	COG2223	nitrite transmembrane transporter activity
AciPR4_0189	COG0640	Transcriptional regulator
AciPR4_0192	COG1538	Outer membrane efflux protein
AciPR4_0206	COG0745	RESPONSE REGULATOR receiver
AciPR4_0206	COG3706	GGDEF domain
AciPR4_0209	COG1278	Cold shock
AciPR4_0211	COG2203	Gaf domain
AciPR4_0211	COG3706	GGDEF domain
AciPR4_0211	COG4251	negative regulation of phosphorylation
AciPR4_0211	COG5001	Diguanylate cyclase
AciPR4_0216	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AciPR4_0217	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AciPR4_0218	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AciPR4_0219	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AciPR4_0222	COG0477	Major facilitator Superfamily
AciPR4_0227	COG2010	Cytochrome c
AciPR4_0230	COG0673	inositol 2-dehydrogenase activity
AciPR4_0237	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AciPR4_0238	COG0405	Gamma-glutamyltransferase
AciPR4_0243	COG0017	Asparaginyl-tRNA synthetase
AciPR4_0254	COG0012	GTP binding
AciPR4_0259	COG1181	Belongs to the D-alanine--D-alanine ligase family
AciPR4_0262	COG2134	cdp-diacylglycerol pyrophosphatase
AciPR4_0264	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AciPR4_0269	COG0521	Mo-molybdopterin cofactor biosynthetic process
AciPR4_0272	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AciPR4_0275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AciPR4_0276	COG0540	Belongs to the ATCase OTCase family
AciPR4_0278	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AciPR4_0282	COG0789	Transcriptional regulator
AciPR4_0284	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AciPR4_0285	COG1322	Protein conserved in bacteria
AciPR4_0287	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AciPR4_0288	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AciPR4_0300	COG4251	negative regulation of phosphorylation
AciPR4_0301	COG0784	Response regulator, receiver
AciPR4_0302	COG4191	Histidine kinase
AciPR4_0314	COG0429	hydrolase of the alpha beta-hydrolase fold
AciPR4_0318	COG3706	GGDEF domain
AciPR4_0319	COG2814	Major facilitator Superfamily
AciPR4_0321	COG0416	fatty acid biosynthetic process
AciPR4_0322	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AciPR4_0326	COG0537	adenosine 5'-monophosphoramidase activity
AciPR4_0327	COG0501	Belongs to the peptidase M48B family
AciPR4_0336	COG3387	PFAM Glycoside hydrolase 15-related
AciPR4_0340	COG0784	Response regulator, receiver
AciPR4_0341	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AciPR4_0345	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AciPR4_0348	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AciPR4_0353	COG0124	histidyl-tRNA synthetase
AciPR4_0359	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AciPR4_0361	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AciPR4_0361	COG0546	phosphoglycolate phosphatase activity
AciPR4_0362	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AciPR4_0364	COG0531	amino acid
AciPR4_0365	COG0165	Argininosuccinate lyase
AciPR4_0367	COG1940	carbohydrate kinase activity
AciPR4_0370	COG3383	formate dehydrogenase (NAD+) activity
AciPR4_0374	COG0564	pseudouridine synthase activity
AciPR4_0375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AciPR4_0376	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AciPR4_0377	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AciPR4_0384	COG0081	regulation of translation
AciPR4_0385	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AciPR4_0386	COG0222	ribosome binding
AciPR4_0388	COG0085	RNA polymerase activity
AciPR4_0389	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AciPR4_0393	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AciPR4_0396	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AciPR4_0408	COG1472	Belongs to the glycosyl hydrolase 3 family
AciPR4_0411	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AciPR4_0411	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AciPR4_0412	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AciPR4_0418	COG3537	Alpha-1,2-mannosidase
AciPR4_0420	COG0562	UDP-galactopyranose mutase
AciPR4_0427	COG1131	(ABC) transporter
AciPR4_0429	COG1505	serine-type exopeptidase activity
AciPR4_0431	COG0251	oxidation-reduction process
AciPR4_0433	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AciPR4_0435	COG1335	isochorismatase
AciPR4_0438	COG3547	Transposase (IS116 IS110 IS902 family)
AciPR4_0440	COG0577	efflux transmembrane transporter activity
AciPR4_0440	COG1136	(ABC) transporter
AciPR4_0441	COG0251	oxidation-reduction process
AciPR4_0450	COG1595	DNA-templated transcription, initiation
AciPR4_0452	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AciPR4_0453	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AciPR4_0458	COG0667	Aldo Keto reductase
AciPR4_0462	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_0463	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AciPR4_0468	COG1231	oxidoreductase activity
AciPR4_0470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AciPR4_0473	COG3733	amine oxidase
AciPR4_0475	COG2814	Major facilitator Superfamily
AciPR4_0479	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AciPR4_0480	COG2211	Major facilitator Superfamily
AciPR4_0481	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AciPR4_0486	COG0058	SHG alpha-glucan phosphorylase activity
AciPR4_0487	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AciPR4_0488	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AciPR4_0493	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AciPR4_0499	COG0577	efflux transmembrane transporter activity
AciPR4_0501	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AciPR4_0502	COG0237	dephospho-CoA kinase activity
AciPR4_0503	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AciPR4_0504	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AciPR4_0505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AciPR4_0506	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AciPR4_0507	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AciPR4_0511	COG0698	ribose 5-phosphate isomerase
AciPR4_0512	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_0514	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AciPR4_0515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AciPR4_0516	COG0363	glucosamine-6-phosphate deaminase activity
AciPR4_0518	COG0308	aminopeptidase N
AciPR4_0519	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AciPR4_0520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AciPR4_0522	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AciPR4_0526	COG0525	valine-tRNA ligase activity
AciPR4_0528	COG3693	PFAM glycoside hydrolase, family 10
AciPR4_0528	COG2382	esterase
AciPR4_0530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AciPR4_0531	COG0322	excinuclease ABC activity
AciPR4_0532	COG0312	modulator of DNA gyrase
AciPR4_0533	COG0312	modulator of DNA gyrase
AciPR4_0534	COG2318	DinB family
AciPR4_0537	COG0254	rRNA binding
AciPR4_0539	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AciPR4_0542	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AciPR4_0546	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AciPR4_0547	COG0754	glutathionylspermidine amidase activity
AciPR4_0549	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AciPR4_0551	COG0328	RNA-DNA hybrid ribonuclease activity
AciPR4_0551	COG0406	alpha-ribazole phosphatase activity
AciPR4_0557	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AciPR4_0558	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AciPR4_0559	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AciPR4_0561	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_0562	COG1309	transcriptional regulator
AciPR4_0563	COG2205	protein histidine kinase activity
AciPR4_0563	COG0784	Response regulator, receiver
AciPR4_0564	COG1136	(ABC) transporter
AciPR4_0564	COG0577	efflux transmembrane transporter activity
AciPR4_0565	COG0667	Aldo Keto reductase
AciPR4_0566	COG1309	transcriptional regulator
AciPR4_0572	COG0463	Glycosyl transferase, family 2
AciPR4_0572	COG1216	Glycosyl transferase, family 2
AciPR4_0573	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AciPR4_0575	COG2204	response regulator
AciPR4_0576	COG2204	response regulator
AciPR4_0577	COG0438	transferase activity, transferring glycosyl groups
AciPR4_0577	COG0297	glycogen (starch) synthase activity
AciPR4_0580	COG0438	transferase activity, transferring glycosyl groups
AciPR4_0581	COG1215	transferase activity, transferring glycosyl groups
AciPR4_0582	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AciPR4_0583	COG0489	protein tyrosine kinase activity
AciPR4_0584	COG3409	Peptidoglycan-binding domain 1 protein
AciPR4_0584	COG3267	Type II secretory pathway component ExeA
AciPR4_0585	COG0489	protein tyrosine kinase activity
AciPR4_0585	COG3206	protein involved in exopolysaccharide biosynthesis
AciPR4_0587	COG1596	polysaccharide export
AciPR4_0595	COG0793	Belongs to the peptidase S41A family
AciPR4_0596	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AciPR4_0597	COG3481	metal-dependent phosphohydrolase, HD sub domain
AciPR4_0600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AciPR4_0601	COG0242	peptide deformylase activity
AciPR4_0602	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AciPR4_0603	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AciPR4_0603	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AciPR4_0604	COG0515	serine threonine protein kinase
AciPR4_0604	COG2815	serine threonine protein kinase
AciPR4_0605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AciPR4_0606	COG2226	methyltransferase
AciPR4_0607	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AciPR4_0610	COG0805	protein transport
AciPR4_0611	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AciPR4_0613	COG1272	protein, Hemolysin III
AciPR4_0614	COG2272	Belongs to the type-B carboxylesterase lipase family
AciPR4_0616	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AciPR4_0620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AciPR4_0622	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AciPR4_0623	COG1278	Cold shock
AciPR4_0639	COG2855	membrane
AciPR4_0645	COG3706	GGDEF domain
AciPR4_0645	COG0745	RESPONSE REGULATOR receiver
AciPR4_0647	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AciPR4_0649	COG0572	uridine kinase
AciPR4_0657	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AciPR4_0658	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AciPR4_0659	COG0295	cytidine deaminase activity
AciPR4_0660	COG1201	RNA secondary structure unwinding
AciPR4_0661	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AciPR4_0663	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AciPR4_0664	COG0442	prolyl-tRNA aminoacylation
AciPR4_0667	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AciPR4_0669	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AciPR4_0672	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AciPR4_0673	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AciPR4_0675	COG0037	tRNA processing
AciPR4_0676	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AciPR4_0679	COG1396	sequence-specific DNA binding
AciPR4_0681	COG3706	GGDEF domain
AciPR4_0681	COG5001	Diguanylate cyclase
AciPR4_0681	COG2203	Gaf domain
AciPR4_0681	COG4251	negative regulation of phosphorylation
AciPR4_0691	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AciPR4_0698	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AciPR4_0701	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AciPR4_0703	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AciPR4_0704	COG0793	Belongs to the peptidase S41A family
AciPR4_0705	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AciPR4_0706	COG0196	riboflavin kinase activity
AciPR4_0707	COG0321	lipoyl(octanoyl) transferase activity
AciPR4_0707	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AciPR4_0709	COG0354	folic acid binding
AciPR4_0711	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AciPR4_0714	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AciPR4_0715	COG1619	proteins homologs of microcin C7 resistance protein MccF
AciPR4_0716	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AciPR4_0719	COG0330	HflC and HflK could
AciPR4_0725	COG1063	alcohol dehydrogenase
AciPR4_0726	COG0156	8-amino-7-oxononanoate synthase activity
AciPR4_0730	COG3590	peptidase
AciPR4_0734	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AciPR4_0736	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_0747	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_0751	COG0659	secondary active sulfate transmembrane transporter activity
AciPR4_0755	COG3781	membrane
AciPR4_0760	COG1136	(ABC) transporter
AciPR4_0762	COG0736	holo-[acyl-carrier-protein] synthase activity
AciPR4_0765	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AciPR4_0766	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AciPR4_0767	COG1187	pseudouridine synthase activity
AciPR4_0770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AciPR4_0774	COG1216	Glycosyl transferase, family 2
AciPR4_0775	COG0513	Belongs to the DEAD box helicase family
AciPR4_0778	COG0438	transferase activity, transferring glycosyl groups
AciPR4_0779	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AciPR4_0780	COG2204	response regulator
AciPR4_0790	COG1285	pathogenesis
AciPR4_0792	COG1607	acyl-coa hydrolase
AciPR4_0793	COG0489	protein tyrosine kinase activity
AciPR4_0794	COG1420	regulation of RNA biosynthetic process
AciPR4_0795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AciPR4_0796	COG0484	heat shock protein binding
AciPR4_0797	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AciPR4_0798	COG1760	l-serine dehydratase
AciPR4_0800	COG0606	chelatase, subunit chli
AciPR4_0802	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AciPR4_0803	COG2199	diguanylate cyclase activity
AciPR4_0803	COG2202	Pas domain
AciPR4_0803	COG2200	EAL domain
AciPR4_0804	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AciPR4_0807	COG0038	chloride channel
AciPR4_0817	COG1940	carbohydrate kinase activity
AciPR4_0821	COG2271	Major facilitator Superfamily
AciPR4_0822	COG4585	Histidine kinase
AciPR4_0823	COG2197	response regulator
AciPR4_0825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AciPR4_0829	COG3964	amidohydrolase
AciPR4_0835	COG2197	response regulator
AciPR4_0836	COG2197	response regulator
AciPR4_0837	COG2885	chlorophyll binding
AciPR4_0838	COG4221	oxidoreductase activity
AciPR4_0842	COG1968	undecaprenyl-diphosphatase activity
AciPR4_0846	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AciPR4_0848	COG2171	N-acyltransferase activity
AciPR4_0849	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AciPR4_0853	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AciPR4_0856	COG2309	aminopeptidase activity
AciPR4_0858	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AciPR4_0859	COG0527	aspartate kinase activity
AciPR4_0863	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AciPR4_0865	COG0741	lytic transglycosylase activity
AciPR4_0866	COG0561	phosphatase activity
AciPR4_0867	COG0697	spore germination
AciPR4_0871	COG1792	Involved in formation and maintenance of cell shape
AciPR4_0874	COG5000	phosphorelay sensor kinase activity
AciPR4_0875	COG2204	response regulator
AciPR4_0876	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AciPR4_0877	COG4535	Mg2 and Co2 transporter CorC
AciPR4_0878	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AciPR4_0882	COG0268	Binds directly to 16S ribosomal RNA
AciPR4_0883	COG0768	penicillin binding
AciPR4_0884	COG0772	Belongs to the SEDS family
AciPR4_0886	COG1530	ribonuclease E activity
AciPR4_0886	COG1530	ribonuclease E activity
AciPR4_0889	COG0006	proline dipeptidase activity
AciPR4_0893	COG0644	oxidoreductase
AciPR4_0897	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AciPR4_0898	COG0629	single-stranded DNA binding
AciPR4_0901	COG0463	Glycosyl transferase, family 2
AciPR4_0904	COG2322	membrane
AciPR4_0905	COG0109	protoheme IX farnesyltransferase activity
AciPR4_0906	COG0628	permease
AciPR4_0907	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AciPR4_0909	COG1595	DNA-templated transcription, initiation
AciPR4_0910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AciPR4_0911	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AciPR4_0914	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AciPR4_0915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AciPR4_0916	COG0772	Belongs to the SEDS family
AciPR4_0917	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AciPR4_0919	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AciPR4_0920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AciPR4_0923	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AciPR4_0924	COG0768	penicillin binding
AciPR4_0925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AciPR4_0925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AciPR4_0926	COG0802	atpase or kinase
AciPR4_0927	COG2267	carboxylic ester hydrolase activity
AciPR4_0928	COG4977	sequence-specific DNA binding
AciPR4_0930	COG0783	Belongs to the Dps family
AciPR4_0931	COG0488	(ABC) transporter
AciPR4_0933	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AciPR4_0935	COG0667	Aldo Keto reductase
AciPR4_0937	COG0860	N-Acetylmuramoyl-L-alanine amidase
AciPR4_0942	COG1214	PFAM Peptidase M22, glycoprotease
AciPR4_0943	COG0456	acetyltransferase
AciPR4_0944	COG0688	phosphatidylethanolamine metabolic process
AciPR4_0945	COG1183	phosphatidylcholine synthase activity
AciPR4_0950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AciPR4_0952	COG0167	dihydroorotate dehydrogenase activity
AciPR4_0954	COG0138	bifunctional purine biosynthesis protein purh
AciPR4_0955	COG0457	Tetratricopeptide repeat
AciPR4_0956	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AciPR4_0959	COG0726	polysaccharide deacetylase
AciPR4_0962	COG0492	ferredoxin-NADP+ reductase activity
AciPR4_0963	COG3852	Histidine kinase
AciPR4_0969	COG2207	Transcriptional regulator
AciPR4_0970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AciPR4_0972	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AciPR4_0974	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AciPR4_0976	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AciPR4_0980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AciPR4_0981	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AciPR4_0982	COG0740	serine-type endopeptidase activity
AciPR4_0983	COG0544	peptidyl-prolyl cis-trans isomerase activity
AciPR4_0985	COG1573	uracil-dna glycosylase
AciPR4_0987	COG0542	response to heat
AciPR4_0988	COG1136	(ABC) transporter
AciPR4_0990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AciPR4_0991	COG0347	Belongs to the P(II) protein family
AciPR4_0992	COG0004	ammonium transporteR
AciPR4_0994	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AciPR4_1000	COG0538	isocitrate dehydrogenase activity
AciPR4_1001	COG0579	oxidoreductase
AciPR4_1010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AciPR4_1011	COG1053	succinate dehydrogenase
AciPR4_1012	COG2009	succinate dehydrogenase
AciPR4_1015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AciPR4_1016	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AciPR4_1018	COG4783	chaperone-mediated protein folding
AciPR4_1023	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AciPR4_1024	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AciPR4_1031	COG1846	Transcriptional regulator
AciPR4_1032	COG0346	lactoylglutathione lyase activity
AciPR4_1038	COG0745	RESPONSE REGULATOR receiver
AciPR4_1039	COG3850	Histidine kinase
AciPR4_1039	COG5002	protein histidine kinase activity
AciPR4_1042	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AciPR4_1046	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AciPR4_1047	COG0667	Aldo Keto reductase
AciPR4_1055	COG4702	Belongs to the UPF0303 family
AciPR4_1056	COG0277	FAD linked oxidase domain protein
AciPR4_1056	COG0247	lactate metabolic process
AciPR4_1057	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AciPR4_1059	COG2271	Major facilitator Superfamily
AciPR4_1060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AciPR4_1061	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_1062	COG1063	alcohol dehydrogenase
AciPR4_1066	COG0302	gtp cyclohydrolase
AciPR4_1067	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AciPR4_1069	COG0577	efflux transmembrane transporter activity
AciPR4_1069	COG1136	(ABC) transporter
AciPR4_1070	COG1136	(ABC) transporter
AciPR4_1070	COG0577	efflux transmembrane transporter activity
AciPR4_1071	COG1733	regulation of RNA biosynthetic process
AciPR4_1073	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AciPR4_1074	COG0515	serine threonine protein kinase
AciPR4_1074	COG2815	serine threonine protein kinase
AciPR4_1090	COG3501	Rhs element vgr protein
AciPR4_1104	COG0747	negative chemotaxis
AciPR4_1106	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AciPR4_1112	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AciPR4_1113	COG0181	hydroxymethylbilane synthase activity
AciPR4_1115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AciPR4_1117	COG0586	Pfam SNARE associated Golgi protein
AciPR4_1118	COG0701	Predicted permease
AciPR4_1120	COG1360	Flagellar Motor Protein
AciPR4_1121	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AciPR4_1122	COG1582	Flagellar protein (FlbD)
AciPR4_1123	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AciPR4_1124	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AciPR4_1129	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AciPR4_1131	COG0028	Belongs to the TPP enzyme family
AciPR4_1132	COG0129	dihydroxy-acid dehydratase activity
AciPR4_1134	COG0066	3-isopropylmalate dehydratase activity
AciPR4_1135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AciPR4_1137	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AciPR4_1138	COG0583	DNA-binding transcription factor activity
AciPR4_1145	COG2323	membrane
AciPR4_1147	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AciPR4_1150	COG1301	dicarboxylic acid transport
AciPR4_1151	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AciPR4_1153	COG4774	siderophore transport
AciPR4_1154	COG3128	pkhd-type hydroxylase
AciPR4_1157	COG2001	Belongs to the MraZ family
AciPR4_1158	COG0275	rRNA processing
AciPR4_1161	COG0730	response to heat
AciPR4_1162	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AciPR4_1164	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AciPR4_1167	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AciPR4_1171	COG1605	Chorismate mutase
AciPR4_1171	COG0077	Prephenate dehydratase
AciPR4_1172	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AciPR4_1174	COG0314	molybdopterin synthase activity
AciPR4_1179	COG1381	Involved in DNA repair and RecF pathway recombination
AciPR4_1184	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AciPR4_1185	COG3842	ATPase activity
AciPR4_1188	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AciPR4_1189	COG0083	homoserine kinase activity
AciPR4_1196	COG3325	Belongs to the glycosyl hydrolase 18 family
AciPR4_1196	COG3469	chitinase activity
AciPR4_1201	COG0667	Aldo Keto reductase
AciPR4_1205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AciPR4_1217	COG1012	belongs to the aldehyde dehydrogenase family
AciPR4_1219	COG2197	response regulator
AciPR4_1231	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AciPR4_1239	COG4585	Histidine kinase
AciPR4_1240	COG2197	response regulator
AciPR4_1245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AciPR4_1246	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AciPR4_1248	COG0512	Glutamine amidotransferase of anthranilate synthase
AciPR4_1250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AciPR4_1251	COG2267	carboxylic ester hydrolase activity
AciPR4_1252	COG1254	Belongs to the acylphosphatase family
AciPR4_1253	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AciPR4_1254	COG1064	alcohol dehydrogenase
AciPR4_1259	COG1570	exodeoxyribonuclease VII activity
AciPR4_1260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AciPR4_1265	COG3706	GGDEF domain
AciPR4_1269	COG3706	GGDEF domain
AciPR4_1269	COG2203	Gaf domain
AciPR4_1269	COG4251	negative regulation of phosphorylation
AciPR4_1269	COG5001	Diguanylate cyclase
AciPR4_1270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AciPR4_1273	COG0577	efflux transmembrane transporter activity
AciPR4_1273	COG1136	(ABC) transporter
AciPR4_1274	COG1695	Transcriptional regulator
AciPR4_1275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AciPR4_1276	COG3507	Belongs to the glycosyl hydrolase 43 family
AciPR4_1278	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AciPR4_1280	COG2860	membrane
AciPR4_1284	COG1027	Aspartate ammonia-lyase
AciPR4_1288	COG0492	ferredoxin-NADP+ reductase activity
AciPR4_1289	COG4191	Histidine kinase
AciPR4_1291	COG1131	(ABC) transporter
AciPR4_1292	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AciPR4_1296	COG3537	Alpha-1,2-mannosidase
AciPR4_1297	COG0752	glycyl-tRNA synthetase alpha subunit
AciPR4_1298	COG0751	glycine-tRNA ligase activity
AciPR4_1302	COG1137	ATPase activity
AciPR4_1305	COG1660	Displays ATPase and GTPase activities
AciPR4_1306	COG1132	(ABC) transporter
AciPR4_1307	COG1561	YicC-like family, N-terminal region
AciPR4_1308	COG0194	GDP metabolic process
AciPR4_1309	COG1758	RNA polymerase activity
AciPR4_1310	COG1573	uracil-dna glycosylase
AciPR4_1311	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AciPR4_1312	COG0776	regulation of translation
AciPR4_1313	COG0717	Belongs to the dCTP deaminase family
AciPR4_1316	COG1560	Kdo2-lipid A biosynthetic process
AciPR4_1317	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AciPR4_1320	COG0646	methionine synthase
AciPR4_1320	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AciPR4_1321	COG1722	exodeoxyribonuclease VII activity
AciPR4_1324	COG0142	geranyltranstransferase activity
AciPR4_1325	COG1666	GTP binding
AciPR4_1326	COG0084	hydrolase, TatD family'
AciPR4_1328	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AciPR4_1328	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AciPR4_1330	COG5520	Belongs to the glycosyl hydrolase 30 family
AciPR4_1331	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AciPR4_1334	COG1940	carbohydrate kinase activity
AciPR4_1336	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AciPR4_1338	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AciPR4_1340	COG0109	protoheme IX farnesyltransferase activity
AciPR4_1340	COG1612	heme a metabolic process
AciPR4_1341	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AciPR4_1343	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AciPR4_1347	COG0681	Belongs to the peptidase S26 family
AciPR4_1348	COG0149	triose-phosphate isomerase activity
AciPR4_1349	COG0126	phosphoglycerate kinase activity
AciPR4_1351	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AciPR4_1353	COG1125	glycine betaine transport
AciPR4_1353	COG0517	IMP dehydrogenase activity
AciPR4_1361	COG4968	Prepilin-type N-terminal cleavage methylation domain
AciPR4_1362	COG1595	DNA-templated transcription, initiation
AciPR4_1366	COG0577	efflux transmembrane transporter activity
AciPR4_1366	COG1136	(ABC) transporter
AciPR4_1367	COG2267	carboxylic ester hydrolase activity
AciPR4_1375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AciPR4_1384	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AciPR4_1385	COG1917	Cupin 2, conserved barrel domain protein
AciPR4_1385	COG2207	Transcriptional regulator
AciPR4_1386	COG0612	Peptidase, M16
AciPR4_1387	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AciPR4_1388	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AciPR4_1391	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AciPR4_1391	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AciPR4_1395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AciPR4_1397	COG0457	Tetratricopeptide repeat
AciPR4_1402	COG0018	arginyl-trna synthetase
AciPR4_1403	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AciPR4_1404	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AciPR4_1405	COG1450	Type ii and iii secretion system protein
AciPR4_1410	COG3956	TIGRFAM MazG family protein
AciPR4_1412	COG4948	Mandelate Racemase Muconate Lactonizing
AciPR4_1418	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AciPR4_1421	COG1832	CoA-binding protein
AciPR4_1426	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AciPR4_1427	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AciPR4_1432	COG1595	DNA-templated transcription, initiation
AciPR4_1433	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AciPR4_1434	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AciPR4_1436	COG0577	efflux transmembrane transporter activity
AciPR4_1436	COG1136	(ABC) transporter
AciPR4_1438	COG0673	inositol 2-dehydrogenase activity
AciPR4_1440	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AciPR4_1441	COG1349	DNA-binding transcription factor activity
AciPR4_1442	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AciPR4_1446	COG2814	Major facilitator Superfamily
AciPR4_1448	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AciPR4_1450	COG1136	(ABC) transporter
AciPR4_1450	COG0577	efflux transmembrane transporter activity
AciPR4_1458	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AciPR4_1459	COG1085	galactose-1-phosphate uridylyltransferase
AciPR4_1461	COG0247	lactate metabolic process
AciPR4_1463	COG1556	Lactate utilization protein
AciPR4_1466	COG1476	TRANSCRIPTIONal
AciPR4_1467	COG4952	isomerase
AciPR4_1469	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_1469	COG3347	Dehydrogenase
AciPR4_1470	COG1070	Carbohydrate kinase
AciPR4_1476	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AciPR4_1477	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AciPR4_1480	COG0463	Glycosyl transferase, family 2
AciPR4_1482	COG0657	acetylesterase activity
AciPR4_1482	COG2755	lipolytic protein G-D-S-L family
AciPR4_1494	COG0515	serine threonine protein kinase
AciPR4_1494	COG2815	serine threonine protein kinase
AciPR4_1499	COG0148	phosphopyruvate hydratase activity
AciPR4_1500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AciPR4_1502	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AciPR4_1503	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AciPR4_1504	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AciPR4_1513	COG2514	catechol 2,3-dioxygenase activity
AciPR4_1514	COG0217	transcriptional regulatory protein
AciPR4_1518	COG2826	transposase and inactivated derivatives, IS30 family
AciPR4_1520	COG1595	DNA-templated transcription, initiation
AciPR4_1521	COG0739	heme binding
AciPR4_1521	COG0741	lytic transglycosylase activity
AciPR4_1521	COG1196	nuclear chromosome segregation
AciPR4_1522	COG0577	efflux transmembrane transporter activity
AciPR4_1522	COG1136	(ABC) transporter
AciPR4_1523	COG0577	efflux transmembrane transporter activity
AciPR4_1532	COG2084	Dehydrogenase
AciPR4_1533	COG1620	l-lactate permease
AciPR4_1534	COG2186	Transcriptional regulator
AciPR4_1536	COG0745	RESPONSE REGULATOR receiver
AciPR4_1537	COG0642	Histidine kinase
AciPR4_1548	COG1609	Transcriptional regulator
AciPR4_1549	COG0457	Tetratricopeptide repeat
AciPR4_1550	COG2814	Major facilitator Superfamily
AciPR4_1555	COG3275	phosphorelay sensor kinase activity
AciPR4_1556	COG3279	Response regulator of the LytR AlgR family
AciPR4_1562	COG1858	cytochrome C peroxidase
AciPR4_1563	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AciPR4_1564	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AciPR4_1565	COG0477	Major facilitator Superfamily
AciPR4_1570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AciPR4_1572	COG3119	arylsulfatase activity
AciPR4_1574	COG3119	arylsulfatase activity
AciPR4_1582	COG3275	phosphorelay sensor kinase activity
AciPR4_1583	COG3279	Response regulator of the LytR AlgR family
AciPR4_1592	COG0823	Involved in the tonB-independent uptake of proteins
AciPR4_1594	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AciPR4_1595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AciPR4_1638	COG0604	alcohol dehydrogenase
AciPR4_1639	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AciPR4_1642	COG0383	alpha-mannosidase activity
AciPR4_1645	COG3537	Alpha-1,2-mannosidase
AciPR4_1651	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AciPR4_1658	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AciPR4_1659	COG1846	Transcriptional regulator
AciPR4_1662	COG0667	Aldo Keto reductase
AciPR4_1663	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AciPR4_1665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AciPR4_1666	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AciPR4_1669	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AciPR4_1671	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AciPR4_1673	COG2201	protein-glutamate methylesterase activity
AciPR4_1676	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AciPR4_1677	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AciPR4_1677	COG1648	precorrin-2 dehydrogenase activity
AciPR4_1678	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AciPR4_1681	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AciPR4_1685	COG1904	glucuronate isomerase
AciPR4_1686	COG3265	gluconokinase activity
AciPR4_1687	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_1688	COG1691	(AIR) carboxylase
AciPR4_1689	COG0251	oxidation-reduction process
AciPR4_1690	COG1606	tRNA processing
AciPR4_1691	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_1694	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AciPR4_1695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AciPR4_1699	COG0383	alpha-mannosidase activity
AciPR4_1700	COG3345	alpha-galactosidase
AciPR4_1705	COG2706	6-phosphogluconolactonase activity
AciPR4_1706	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AciPR4_1709	COG0235	Class ii aldolase
AciPR4_1715	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AciPR4_1716	COG2755	lipolytic protein G-D-S-L family
AciPR4_1718	COG2755	lipolytic protein G-D-S-L family
AciPR4_1735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AciPR4_1740	COG2857	Cytochrome c1
AciPR4_1740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AciPR4_1743	COG4585	Histidine kinase
AciPR4_1744	COG2197	response regulator
AciPR4_1747	COG1752	Esterase of the alpha-beta hydrolase superfamily
AciPR4_1748	COG0166	Belongs to the GPI family
AciPR4_1753	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AciPR4_1754	COG1295	ribonuclease BN
AciPR4_1755	COG2208	phosphoserine phosphatase activity
AciPR4_1755	COG2770	Histidine kinase
AciPR4_1758	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AciPR4_1760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AciPR4_1764	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AciPR4_1768	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AciPR4_1771	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AciPR4_1773	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AciPR4_1777	COG0778	Nitroreductase
AciPR4_1779	COG0163	prenyltransferase activity
AciPR4_1782	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AciPR4_1785	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_1786	COG0590	tRNA wobble adenosine to inosine editing
AciPR4_1790	COG2957	Belongs to the agmatine deiminase family
AciPR4_1793	COG1945	arginine decarboxylase activity
AciPR4_1799	COG0556	nucleotide-excision repair
AciPR4_1800	COG2311	Membrane
AciPR4_1801	COG0477	Major facilitator Superfamily
AciPR4_1802	COG0546	phosphoglycolate phosphatase activity
AciPR4_1804	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AciPR4_1805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AciPR4_1806	COG0745	RESPONSE REGULATOR receiver
AciPR4_1809	COG1815	bacterial-type flagellum-dependent cell motility
AciPR4_1810	COG1558	bacterial-type flagellum-dependent cell motility
AciPR4_1811	COG1677	Flagellar hook-basal body complex protein FliE
AciPR4_1813	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AciPR4_1818	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AciPR4_1819	COG1749	Flagellar hook protein flgE
AciPR4_1825	COG1684	flagellar biosynthetic protein fliR
AciPR4_1826	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AciPR4_1827	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AciPR4_1828	COG1191	sigma factor activity
AciPR4_1830	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AciPR4_1830	COG1776	CheC inhibitor of MCP methylation
AciPR4_1831	COG4786	Flagellar basal body rod
AciPR4_1832	COG4786	Flagellar basal body rod
AciPR4_1834	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AciPR4_1835	COG1706	bacterial-type flagellum-dependent cell motility
AciPR4_1839	COG1256	bacterial-type flagellum assembly
AciPR4_1839	COG4786	Flagellar basal body rod
AciPR4_1844	COG1819	glycosyl
AciPR4_1846	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AciPR4_1847	COG1185	polyribonucleotide nucleotidyltransferase activity
AciPR4_1849	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AciPR4_1853	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AciPR4_1854	COG1063	alcohol dehydrogenase
AciPR4_1855	COG1562	ergosterol biosynthetic process
AciPR4_1856	COG1562	ergosterol biosynthetic process
AciPR4_1857	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AciPR4_1865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AciPR4_1866	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AciPR4_1868	COG3411	Ferredoxin
AciPR4_1871	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AciPR4_1873	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AciPR4_1875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AciPR4_1877	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AciPR4_1878	COG1956	GAF domain-containing protein
AciPR4_1888	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AciPR4_1889	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AciPR4_1890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AciPR4_1894	COG0009	L-threonylcarbamoyladenylate synthase
AciPR4_1900	COG0477	Major facilitator Superfamily
AciPR4_1905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AciPR4_1906	COG0436	Aminotransferase
AciPR4_1907	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AciPR4_1908	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AciPR4_1916	COG3620	sequence-specific DNA binding
AciPR4_1919	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AciPR4_1923	COG1136	(ABC) transporter
AciPR4_1923	COG0577	efflux transmembrane transporter activity
AciPR4_1927	COG2818	Glycosylase
AciPR4_1934	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AciPR4_1936	COG0617	tRNA 3'-terminal CCA addition
AciPR4_1939	COG0825	malonyl-CoA metabolic process
AciPR4_1945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AciPR4_1946	COG0351	phosphomethylpyrimidine kinase
AciPR4_1950	COG0438	transferase activity, transferring glycosyl groups
AciPR4_1952	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AciPR4_1965	COG0438	transferase activity, transferring glycosyl groups
AciPR4_1967	COG0438	transferase activity, transferring glycosyl groups
AciPR4_1968	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AciPR4_1968	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AciPR4_1970	COG2080	2 iron, 2 sulfur cluster binding
AciPR4_1971	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AciPR4_1972	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AciPR4_1973	COG0514	ATP-dependent DNA helicase (RecQ)
AciPR4_1974	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AciPR4_1975	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AciPR4_1976	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AciPR4_1977	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AciPR4_1982	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AciPR4_1983	COG4191	Histidine kinase
AciPR4_1985	COG1063	alcohol dehydrogenase
AciPR4_1988	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AciPR4_1990	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_1994	COG1657	PFAM Prenyltransferase squalene oxidase
AciPR4_1995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AciPR4_1996	COG0497	DNA recombination
AciPR4_2001	COG2885	chlorophyll binding
AciPR4_2002	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AciPR4_2004	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AciPR4_2005	COG0505	Belongs to the CarA family
AciPR4_2008	COG2259	Doxx family
AciPR4_2010	COG0022	dehydrogenase e1 component
AciPR4_2013	COG0668	transmembrane transport
AciPR4_2014	COG1331	Highly conserved protein containing a thioredoxin domain
AciPR4_2016	COG0101	tRNA pseudouridine synthase activity
AciPR4_2019	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AciPR4_2025	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AciPR4_2026	COG0534	Mate efflux family protein
AciPR4_2035	COG0673	inositol 2-dehydrogenase activity
AciPR4_2036	COG0531	amino acid
AciPR4_2037	COG0531	amino acid
AciPR4_2038	COG0352	thiamine-phosphate diphosphorylase activity
AciPR4_2039	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_2040	COG2070	2-Nitropropane dioxygenase
AciPR4_2041	COG2311	Membrane
AciPR4_2043	COG0439	Biotin carboxylase
AciPR4_2044	COG0511	ligase activity, forming carbon-carbon bonds
AciPR4_2045	COG0006	proline dipeptidase activity
AciPR4_2046	COG1408	metallophosphoesterase
AciPR4_2049	COG2826	transposase and inactivated derivatives, IS30 family
AciPR4_2050	COG0070	glutamate synthase
AciPR4_2050	COG0069	glutamate synthase activity
AciPR4_2050	COG0067	glutamate synthase
AciPR4_2051	COG1438	arginine binding
AciPR4_2052	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AciPR4_2053	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AciPR4_2054	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AciPR4_2055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AciPR4_2056	COG0137	argininosuccinate synthase activity
AciPR4_2057	COG0165	Argininosuccinate lyase
AciPR4_2061	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AciPR4_2062	COG0673	inositol 2-dehydrogenase activity
AciPR4_2066	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AciPR4_2068	COG0028	Belongs to the TPP enzyme family
AciPR4_2075	COG0586	Pfam SNARE associated Golgi protein
AciPR4_2078	COG2183	response to ionizing radiation
AciPR4_2080	COG1595	DNA-templated transcription, initiation
AciPR4_2082	COG4251	negative regulation of phosphorylation
AciPR4_2083	COG0784	Response regulator, receiver
AciPR4_2086	COG5001	Diguanylate cyclase
AciPR4_2088	COG1620	l-lactate permease
AciPR4_2090	COG1410	methionine synthase
AciPR4_2090	COG0646	methionine synthase
AciPR4_2091	COG2197	response regulator
AciPR4_2096	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AciPR4_2097	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AciPR4_2099	COG0535	radical SAM domain protein
AciPR4_2104	COG2205	protein histidine kinase activity
AciPR4_2105	COG0745	RESPONSE REGULATOR receiver
AciPR4_2108	COG4716	Myosin-crossreactive antigen
AciPR4_2110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AciPR4_2111	COG0673	inositol 2-dehydrogenase activity
AciPR4_2117	COG1136	(ABC) transporter
AciPR4_2120	COG1522	sequence-specific DNA binding
AciPR4_2121	COG0179	Fumarylacetoacetate (FAA) hydrolase
AciPR4_2122	COG4948	Mandelate Racemase Muconate Lactonizing
AciPR4_2123	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AciPR4_2126	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AciPR4_2131	COG4191	Histidine kinase
AciPR4_2132	COG2204	response regulator
AciPR4_2133	COG0406	alpha-ribazole phosphatase activity
AciPR4_2137	COG4106	trans-aconitate 2-methyltransferase activity
AciPR4_2138	COG0326	Molecular chaperone. Has ATPase activity
AciPR4_2139	COG1643	Atp-dependent helicase
AciPR4_2144	COG2819	hydrolase of the alpha beta superfamily
AciPR4_2145	COG0228	four-way junction DNA binding
AciPR4_2146	COG1837	Belongs to the UPF0109 family
AciPR4_2147	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AciPR4_2149	COG0336	Belongs to the RNA methyltransferase TrmD family
AciPR4_2151	COG0335	large ribosomal subunit rRNA binding
AciPR4_2153	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AciPR4_2156	COG1414	Transcriptional regulator
AciPR4_2158	COG1696	Membrane protein involved in D-alanine export
AciPR4_2159	COG1482	cell wall glycoprotein biosynthetic process
AciPR4_2161	COG0642	Histidine kinase
AciPR4_2161	COG3850	Histidine kinase
AciPR4_2162	COG0745	RESPONSE REGULATOR receiver
AciPR4_2163	COG0795	lipopolysaccharide-transporting ATPase activity
AciPR4_2164	COG0545	Peptidyl-prolyl cis-trans isomerase
AciPR4_2165	COG1132	(ABC) transporter
AciPR4_2167	COG1566	PFAM secretion protein HlyD family protein
AciPR4_2169	COG0673	inositol 2-dehydrogenase activity
AciPR4_2170	COG0673	inositol 2-dehydrogenase activity
AciPR4_2171	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AciPR4_2175	COG1088	dTDP-glucose 4,6-dehydratase activity
AciPR4_2176	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AciPR4_2184	COG4251	negative regulation of phosphorylation
AciPR4_2184	COG3706	GGDEF domain
AciPR4_2184	COG5001	Diguanylate cyclase
AciPR4_2184	COG2203	Gaf domain
AciPR4_2186	COG0577	efflux transmembrane transporter activity
AciPR4_2186	COG1136	(ABC) transporter
AciPR4_2187	COG1136	(ABC) transporter
AciPR4_2187	COG0577	efflux transmembrane transporter activity
AciPR4_2190	COG0047	phosphoribosylformylglycinamidine synthase activity
AciPR4_2191	COG4464	protein tyrosine phosphatase activity
AciPR4_2192	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_2194	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AciPR4_2195	COG0459	protein refolding
AciPR4_2204	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AciPR4_2205	COG1132	(ABC) transporter
AciPR4_2206	COG1392	Phosphate transport regulator
AciPR4_2207	COG0306	phosphate transporter
AciPR4_2208	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AciPR4_2210	COG1250	3-hydroxyacyl-CoA dehydrogenase
AciPR4_2212	COG1640	4-alpha-glucanotransferase
AciPR4_2214	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AciPR4_2221	COG0745	RESPONSE REGULATOR receiver
AciPR4_2222	COG5002	protein histidine kinase activity
AciPR4_2230	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
AciPR4_2234	COG2207	Transcriptional regulator
AciPR4_2245	COG3220	belongs to the UPF0276 family
AciPR4_2252	COG0823	Involved in the tonB-independent uptake of proteins
AciPR4_2252	COG1506	peptidase
AciPR4_2255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AciPR4_2258	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AciPR4_2261	COG0577	efflux transmembrane transporter activity
AciPR4_2261	COG1136	(ABC) transporter
AciPR4_2265	COG2205	protein histidine kinase activity
AciPR4_2270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AciPR4_2273	COG1917	Cupin 2, conserved barrel domain protein
AciPR4_2273	COG2207	Transcriptional regulator
AciPR4_2275	COG2267	carboxylic ester hydrolase activity
AciPR4_2286	COG1309	transcriptional regulator
AciPR4_2289	COG1538	Outer membrane efflux protein
AciPR4_2291	COG1309	transcriptional regulator
AciPR4_2292	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_2296	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_2305	COG1082	Xylose isomerase domain protein TIM barrel
AciPR4_2308	COG1609	Transcriptional regulator
AciPR4_2319	COG0528	UMP kinase activity
AciPR4_2320	COG0528	UMP kinase activity
AciPR4_2344	COG3620	sequence-specific DNA binding
AciPR4_2345	COG3550	peptidyl-serine autophosphorylation
AciPR4_2358	COG0583	DNA-binding transcription factor activity
AciPR4_2359	COG0582	viral genome integration into host DNA
AciPR4_2363	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_2365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AciPR4_2365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AciPR4_2366	COG2207	Transcriptional regulator
AciPR4_2367	COG1538	Outer membrane efflux protein
AciPR4_2370	COG0667	Aldo Keto reductase
AciPR4_2372	COG1064	alcohol dehydrogenase
AciPR4_2374	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_2375	COG2207	Transcriptional regulator
AciPR4_2376	COG1475	DNA binding
AciPR4_2379	COG1196	nuclear chromosome segregation
AciPR4_2391	COG0629	single-stranded DNA binding
AciPR4_2392	COG4962	Type ii secretion system protein e
AciPR4_2394	COG1396	sequence-specific DNA binding
AciPR4_2411	COG2205	protein histidine kinase activity
AciPR4_2412	COG0745	RESPONSE REGULATOR receiver
AciPR4_2416	COG1953	Uracil, thiamine, allantoin
AciPR4_2418	COG2203	Gaf domain
AciPR4_2418	COG5001	Diguanylate cyclase
AciPR4_2418	COG4251	negative regulation of phosphorylation
AciPR4_2418	COG3706	GGDEF domain
AciPR4_2423	COG1501	Belongs to the glycosyl hydrolase 31 family
AciPR4_2428	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AciPR4_2434	COG0438	transferase activity, transferring glycosyl groups
AciPR4_2441	COG3206	protein involved in exopolysaccharide biosynthesis
AciPR4_2441	COG0489	protein tyrosine kinase activity
AciPR4_2442	COG0438	transferase activity, transferring glycosyl groups
AciPR4_2446	COG0626	cystathionine gamma-synthase activity
AciPR4_2447	COG3394	polysaccharide catabolic process
AciPR4_2448	COG3275	phosphorelay sensor kinase activity
AciPR4_2449	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AciPR4_2452	COG0322	excinuclease ABC activity
AciPR4_2455	COG4771	TonB-dependent receptor
AciPR4_2456	COG2321	neutral zinc metallopeptidase
AciPR4_2457	COG3537	Alpha-1,2-mannosidase
AciPR4_2464	COG0531	amino acid
AciPR4_2465	COG0297	glycogen (starch) synthase activity
AciPR4_2466	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AciPR4_2469	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AciPR4_2470	COG2022	thiamine diphosphate biosynthetic process
AciPR4_2474	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AciPR4_2476	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AciPR4_2477	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AciPR4_2478	COG0649	NAD binding
AciPR4_2483	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AciPR4_2485	COG0713	ATP synthesis coupled electron transport
AciPR4_2488	COG1007	ATP synthesis coupled electron transport
AciPR4_2489	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AciPR4_2490	COG0356	it plays a direct role in the translocation of protons across the membrane
AciPR4_2494	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AciPR4_2495	COG1692	metallophosphoesterase
AciPR4_2497	COG1196	nuclear chromosome segregation
AciPR4_2504	COG2222	sugar isomerase
AciPR4_2505	COG0673	inositol 2-dehydrogenase activity
AciPR4_2507	COG1349	DNA-binding transcription factor activity
AciPR4_2519	COG1392	Phosphate transport regulator
AciPR4_2520	COG0306	phosphate transporter
AciPR4_2522	COG2808	Putative FMN-binding domain
AciPR4_2523	COG0539	negative regulation of cytoplasmic translation
AciPR4_2524	COG1064	alcohol dehydrogenase
AciPR4_2527	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AciPR4_2533	COG2755	lipolytic protein G-D-S-L family
AciPR4_2533	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AciPR4_2535	COG1268	BioY protein
AciPR4_2539	COG0577	efflux transmembrane transporter activity
AciPR4_2539	COG1136	(ABC) transporter
AciPR4_2541	COG2204	response regulator
AciPR4_2543	COG1136	(ABC) transporter
AciPR4_2543	COG0577	efflux transmembrane transporter activity
AciPR4_2544	COG0577	efflux transmembrane transporter activity
AciPR4_2544	COG1136	(ABC) transporter
AciPR4_2547	COG1136	(ABC) transporter
AciPR4_2547	COG0577	efflux transmembrane transporter activity
AciPR4_2550	COG2252	PERMEase
AciPR4_2552	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AciPR4_2552	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AciPR4_2554	COG1127	ABC transporter
AciPR4_2555	COG0746	molybdenum cofactor guanylyltransferase activity
AciPR4_2556	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AciPR4_2557	COG2226	methyltransferase
AciPR4_2559	COG2204	response regulator
AciPR4_2560	COG3852	Histidine kinase
AciPR4_2562	COG0653	protein targeting
AciPR4_2565	COG4974	Belongs to the 'phage' integrase family
AciPR4_2569	COG0601	transmembrane transport
AciPR4_2570	COG1253	flavin adenine dinucleotide binding
AciPR4_2573	COG0494	nUDIX hydrolase
AciPR4_2578	COG1704	LemA family
AciPR4_2582	COG1132	(ABC) transporter
AciPR4_2590	COG0463	Glycosyl transferase, family 2
AciPR4_2593	COG1668	transmembrane transport
AciPR4_2594	COG4152	abc transporter atp-binding protein
AciPR4_2596	COG1363	Peptidase, m42
AciPR4_2606	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AciPR4_2607	COG0438	transferase activity, transferring glycosyl groups
AciPR4_2614	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AciPR4_2614	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AciPR4_2618	COG1819	glycosyl
AciPR4_2621	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AciPR4_2622	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AciPR4_2623	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AciPR4_2625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AciPR4_2628	COG0450	alkyl hydroperoxide reductase
AciPR4_2629	COG0577	efflux transmembrane transporter activity
AciPR4_2629	COG1136	(ABC) transporter
AciPR4_2633	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AciPR4_2634	COG1309	transcriptional regulator
AciPR4_2637	COG4948	Mandelate Racemase Muconate Lactonizing
AciPR4_2638	COG1940	carbohydrate kinase activity
AciPR4_2639	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_2641	COG0673	inositol 2-dehydrogenase activity
AciPR4_2650	COG2382	esterase
AciPR4_2651	COG0531	amino acid
AciPR4_2653	COG1063	alcohol dehydrogenase
AciPR4_2655	COG3254	rhamnose metabolic process
AciPR4_2659	COG3250	beta-galactosidase activity
AciPR4_2668	COG0745	RESPONSE REGULATOR receiver
AciPR4_2669	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AciPR4_2670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AciPR4_2672	COG1538	Outer membrane efflux protein
AciPR4_2678	COG0745	RESPONSE REGULATOR receiver
AciPR4_2681	COG3706	GGDEF domain
AciPR4_2683	COG1450	Type ii and iii secretion system protein
AciPR4_2685	COG1837	Belongs to the UPF0109 family
AciPR4_2689	COG3344	reverse transcriptase
AciPR4_2691	COG0640	Transcriptional regulator
AciPR4_2692	COG0798	PFAM Bile acid sodium symporter
AciPR4_2693	COG1695	Transcriptional regulator
AciPR4_2697	COG0823	Involved in the tonB-independent uptake of proteins
AciPR4_2701	COG0598	Magnesium transport protein CorA
AciPR4_2707	COG1091	dTDP-4-dehydrorhamnose reductase activity
AciPR4_2708	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AciPR4_2708	COG0662	Cupin 2, conserved barrel domain protein
AciPR4_2710	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AciPR4_2717	COG3250	beta-galactosidase activity
AciPR4_2722	COG0577	efflux transmembrane transporter activity
AciPR4_2722	COG1136	(ABC) transporter
AciPR4_2723	COG0577	efflux transmembrane transporter activity
AciPR4_2727	COG0673	inositol 2-dehydrogenase activity
AciPR4_2729	COG2271	Major facilitator Superfamily
AciPR4_2730	COG0363	glucosamine-6-phosphate deaminase activity
AciPR4_2735	COG0673	inositol 2-dehydrogenase activity
AciPR4_2738	COG1414	Transcriptional regulator
AciPR4_2742	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AciPR4_2743	COG0363	glucosamine-6-phosphate deaminase activity
AciPR4_2746	COG1609	Transcriptional regulator
AciPR4_2748	COG1902	pentaerythritol trinitrate reductase activity
AciPR4_2749	COG3118	belongs to the thioredoxin family
AciPR4_2754	COG0366	Alpha amylase catalytic
AciPR4_2768	COG3119	arylsulfatase activity
AciPR4_2770	COG3275	phosphorelay sensor kinase activity
AciPR4_2771	COG3279	Response regulator of the LytR AlgR family
AciPR4_2772	COG2133	pyrroloquinoline quinone binding
AciPR4_2775	COG0745	RESPONSE REGULATOR receiver
AciPR4_2780	COG2115	Belongs to the xylose isomerase family
AciPR4_2784	COG0745	RESPONSE REGULATOR receiver
AciPR4_2784	COG3706	GGDEF domain
AciPR4_2785	COG1595	DNA-templated transcription, initiation
AciPR4_2786	COG0515	serine threonine protein kinase
AciPR4_2788	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_2791	COG1446	asparaginase
AciPR4_2793	COG2423	ornithine cyclodeaminase activity
AciPR4_2794	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AciPR4_2795	COG0601	transmembrane transport
AciPR4_2797	COG4172	Belongs to the ABC transporter superfamily
AciPR4_2799	COG2828	Protein conserved in bacteria
AciPR4_2800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AciPR4_2801	COG4166	transmembrane transport
AciPR4_2804	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AciPR4_2807	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AciPR4_2816	COG1454	alcohol dehydrogenase
AciPR4_2818	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AciPR4_2819	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AciPR4_2820	COG3395	kinase activity
AciPR4_2831	COG0300	oxidoreductase activity
AciPR4_2833	COG3710	Transcriptional regulator
AciPR4_2836	COG1309	transcriptional regulator
AciPR4_2839	COG0492	ferredoxin-NADP+ reductase activity
AciPR4_2841	COG0463	Glycosyl transferase, family 2
AciPR4_2848	COG2186	Transcriptional regulator
AciPR4_2849	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AciPR4_2854	COG2205	protein histidine kinase activity
AciPR4_2855	COG0745	RESPONSE REGULATOR receiver
AciPR4_2857	COG5002	protein histidine kinase activity
AciPR4_2865	COG3852	Histidine kinase
AciPR4_2885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AciPR4_2886	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AciPR4_2886	COG2169	Transcriptional regulator
AciPR4_2888	COG3145	DNA-N1-methyladenine dioxygenase activity
AciPR4_2890	COG3548	integral membrane protein
AciPR4_2891	COG2207	Transcriptional regulator
AciPR4_2893	COG3547	Transposase (IS116 IS110 IS902 family)
AciPR4_2898	COG2442	InterPro IPR007367
AciPR4_2899	COG4634	DNA integration
AciPR4_2900	COG1733	regulation of RNA biosynthetic process
AciPR4_2904	COG2814	Major facilitator Superfamily
AciPR4_2905	COG1566	PFAM secretion protein HlyD family protein
AciPR4_2909	COG2207	Transcriptional regulator
AciPR4_2912	COG1629	transport
AciPR4_2913	COG3128	pkhd-type hydroxylase
AciPR4_2918	COG4191	Histidine kinase
AciPR4_2920	COG3706	GGDEF domain
AciPR4_2921	COG1475	DNA binding
AciPR4_2934	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AciPR4_2946	COG4962	Type ii secretion system protein e
AciPR4_2961	COG1595	DNA-templated transcription, initiation
AciPR4_2964	COG0463	Glycosyl transferase, family 2
AciPR4_2966	COG3547	Transposase (IS116 IS110 IS902 family)
AciPR4_2968	COG0776	regulation of translation
AciPR4_2969	COG0824	Thioesterase
AciPR4_2970	COG1335	isochorismatase
AciPR4_2972	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AciPR4_2975	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AciPR4_2976	COG0750	zinc metalloprotease
AciPR4_2986	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AciPR4_2987	COG0494	nUDIX hydrolase
AciPR4_2988	COG1278	Cold shock
AciPR4_2989	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AciPR4_2989	COG1796	DNA polymerase
AciPR4_2993	COG0372	Belongs to the citrate synthase family
AciPR4_2994	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_2995	COG1418	mRNA catabolic process
AciPR4_2996	COG4774	siderophore transport
AciPR4_3004	COG0583	DNA-binding transcription factor activity
AciPR4_3005	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_3007	COG0482	sulfurtransferase activity
AciPR4_3016	COG1543	Belongs to the glycosyl hydrolase 57 family
AciPR4_3019	COG2062	phosphohistidine phosphatase, SixA
AciPR4_3020	COG0248	Ppx GppA phosphatase
AciPR4_3021	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AciPR4_3024	COG0789	Transcriptional regulator
AciPR4_3025	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_3026	COG0484	heat shock protein binding
AciPR4_3030	COG3549	Plasmid maintenance system killer
AciPR4_3032	COG0443	Heat shock 70 kDa protein
AciPR4_3041	COG0316	Belongs to the HesB IscA family
AciPR4_3044	COG2755	lipolytic protein G-D-S-L family
AciPR4_3044	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AciPR4_3045	COG0528	UMP kinase activity
AciPR4_3046	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AciPR4_3047	COG0052	Belongs to the universal ribosomal protein uS2 family
AciPR4_3048	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AciPR4_3049	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AciPR4_3051	COG0577	efflux transmembrane transporter activity
AciPR4_3057	COG2169	Transcriptional regulator
AciPR4_3057	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AciPR4_3058	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AciPR4_3061	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AciPR4_3062	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AciPR4_3063	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AciPR4_3064	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AciPR4_3065	COG0131	Imidazoleglycerol-phosphate dehydratase
AciPR4_3066	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AciPR4_3067	COG0107	imidazoleglycerol-phosphate synthase activity
AciPR4_3068	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AciPR4_3074	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AciPR4_3076	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AciPR4_3080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AciPR4_3081	COG0509	glycine decarboxylation via glycine cleavage system
AciPR4_3083	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AciPR4_3085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AciPR4_3111	COG0488	(ABC) transporter
AciPR4_3113	COG0330	HflC and HflK could
AciPR4_3114	COG1725	Transcriptional regulator
AciPR4_3116	COG0519	Catalyzes the synthesis of GMP from XMP
AciPR4_3116	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AciPR4_3119	COG0495	leucyl-tRNA aminoacylation
AciPR4_3121	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AciPR4_3124	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AciPR4_3125	COG0758	DNA mediated transformation
AciPR4_3127	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AciPR4_3129	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AciPR4_3132	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AciPR4_3136	COG1058	Belongs to the CinA family
AciPR4_3136	COG1546	Belongs to the CinA family
AciPR4_3137	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AciPR4_3138	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AciPR4_3139	COG0552	protein localization to endoplasmic reticulum
AciPR4_3142	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AciPR4_3142	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AciPR4_3143	COG0307	riboflavin synthase, alpha
AciPR4_3144	COG1435	thymidine kinase activity
AciPR4_3146	COG0393	Putative heavy-metal-binding
AciPR4_3147	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AciPR4_3148	COG0045	succinate-CoA ligase (ADP-forming) activity
AciPR4_3149	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AciPR4_3150	COG0105	UTP biosynthetic process
AciPR4_3154	COG1595	DNA-templated transcription, initiation
AciPR4_3155	COG2032	superoxide dismutase activity
AciPR4_3164	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AciPR4_3165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AciPR4_3167	COG1252	NADH dehydrogenase
AciPR4_3168	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AciPR4_3169	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AciPR4_3170	COG1295	ribonuclease BN
AciPR4_3171	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AciPR4_3175	COG1872	DUF167
AciPR4_3176	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AciPR4_3184	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AciPR4_3191	COG0517	IMP dehydrogenase activity
AciPR4_3191	COG0516	GMP reductase activity
AciPR4_3192	COG2200	EAL domain
AciPR4_3192	COG3287	FIST C domain
AciPR4_3192	COG2199	diguanylate cyclase activity
AciPR4_3194	COG0779	Required for maturation of 30S ribosomal subunits
AciPR4_3195	COG0195	Participates in both transcription termination and antitermination
AciPR4_3196	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AciPR4_3207	COG0203	ribosomal protein L17
AciPR4_3208	COG0202	RNA polymerase activity
AciPR4_3209	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AciPR4_3210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AciPR4_3211	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AciPR4_3212	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AciPR4_3213	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AciPR4_3215	COG0563	adenylate kinase activity
AciPR4_3217	COG0200	Binds to the 23S rRNA
AciPR4_3218	COG1841	ribosomal large subunit assembly
AciPR4_3219	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AciPR4_3220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AciPR4_3221	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AciPR4_3222	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AciPR4_3223	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AciPR4_3224	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AciPR4_3225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AciPR4_3226	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AciPR4_3227	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AciPR4_3228	COG0255	Belongs to the universal ribosomal protein uL29 family
AciPR4_3229	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AciPR4_3230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AciPR4_3231	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AciPR4_3232	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AciPR4_3233	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AciPR4_3234	COG0089	rRNA binding
AciPR4_3235	COG0088	Forms part of the polypeptide exit tunnel
AciPR4_3236	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AciPR4_3237	COG0051	transcription antitermination factor activity, RNA binding
AciPR4_3238	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AciPR4_3239	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AciPR4_3240	COG0049	tRNA binding
AciPR4_3241	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AciPR4_3245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AciPR4_3247	COG1506	peptidase
AciPR4_3247	COG4946	Tricorn protease homolog
AciPR4_3247	COG0823	Involved in the tonB-independent uptake of proteins
AciPR4_3254	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AciPR4_3256	COG0631	protein serine/threonine phosphatase activity
AciPR4_3260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AciPR4_3261	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AciPR4_3262	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AciPR4_3264	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AciPR4_3265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AciPR4_3268	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AciPR4_3269	COG1923	regulation of RNA biosynthetic process
AciPR4_3272	COG2814	Major facilitator Superfamily
AciPR4_3273	COG1309	transcriptional regulator
AciPR4_3281	COG0180	Tryptophanyl-tRNA synthetase
AciPR4_3282	COG1994	Peptidase M50
AciPR4_3291	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AciPR4_3292	COG0745	RESPONSE REGULATOR receiver
AciPR4_3292	COG3706	GGDEF domain
AciPR4_3296	COG0667	Aldo Keto reductase
AciPR4_3298	COG0504	CTP synthase activity
AciPR4_3304	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AciPR4_3308	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AciPR4_3312	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AciPR4_3313	COG2308	Evidence 4 Homologs of previously reported genes of
AciPR4_3316	COG1305	Transglutaminase-like
AciPR4_3320	COG4251	negative regulation of phosphorylation
AciPR4_3321	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AciPR4_3322	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AciPR4_3324	COG0187	DNA topoisomerase II activity
AciPR4_3325	COG4456	Virulence-associated protein
AciPR4_3328	COG0154	amidase activity
AciPR4_3329	COG4221	oxidoreductase activity
AciPR4_3331	COG4095	Psort location CytoplasmicMembrane, score
AciPR4_3340	COG0535	radical SAM domain protein
AciPR4_3341	COG4191	Histidine kinase
AciPR4_3344	COG1611	Belongs to the LOG family
AciPR4_3347	COG0488	(ABC) transporter
AciPR4_3349	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AciPR4_3352	COG0738	Major facilitator superfamily
AciPR4_3353	COG5001	Diguanylate cyclase
AciPR4_3353	COG3300	MHYT domain
AciPR4_3354	COG3300	MHYT domain
AciPR4_3354	COG5001	Diguanylate cyclase
AciPR4_3364	COG1802	Transcriptional regulator
AciPR4_3365	COG1012	belongs to the aldehyde dehydrogenase family
AciPR4_3371	COG3179	chitinase
AciPR4_3374	COG0531	amino acid
AciPR4_3375	COG2814	Major facilitator Superfamily
AciPR4_3376	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AciPR4_3379	COG0438	transferase activity, transferring glycosyl groups
AciPR4_3382	COG1136	(ABC) transporter
AciPR4_3382	COG0577	efflux transmembrane transporter activity
AciPR4_3388	COG4251	negative regulation of phosphorylation
AciPR4_3388	COG2203	Gaf domain
AciPR4_3388	COG5001	Diguanylate cyclase
AciPR4_3388	COG3706	GGDEF domain
AciPR4_3390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AciPR4_3395	COG0242	peptide deformylase activity
AciPR4_3400	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AciPR4_3401	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AciPR4_3402	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AciPR4_3402	COG0515	serine threonine protein kinase
AciPR4_3403	COG0577	efflux transmembrane transporter activity
AciPR4_3404	COG1136	(ABC) transporter
AciPR4_3406	COG1231	oxidoreductase activity
AciPR4_3407	COG1309	transcriptional regulator
AciPR4_3408	COG0300	oxidoreductase activity
AciPR4_3409	COG1040	competence protein
AciPR4_3413	COG0539	negative regulation of cytoplasmic translation
AciPR4_3414	COG0697	spore germination
AciPR4_3416	COG2255	four-way junction helicase activity
AciPR4_3419	COG2826	transposase and inactivated derivatives, IS30 family
AciPR4_3426	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AciPR4_3428	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AciPR4_3433	COG0215	cysteine-tRNA ligase activity
AciPR4_3434	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AciPR4_3435	COG0617	tRNA 3'-terminal CCA addition
AciPR4_3442	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AciPR4_3445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AciPR4_3446	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AciPR4_3449	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_3451	COG0277	FAD linked oxidase domain protein
AciPR4_3455	COG2723	6-phospho-beta-galactosidase activity
AciPR4_3457	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AciPR4_3459	COG0742	ribosomal rna small subunit methyltransferase
AciPR4_3461	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AciPR4_3468	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AciPR4_3471	COG0640	Transcriptional regulator
AciPR4_3472	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_3475	COG0590	tRNA wobble adenosine to inosine editing
AciPR4_3476	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AciPR4_3488	COG0366	Alpha amylase catalytic
AciPR4_3489	COG0366	Alpha amylase catalytic
AciPR4_3492	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AciPR4_3495	COG0210	DNA helicase
AciPR4_3497	COG0531	amino acid
AciPR4_3503	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AciPR4_3504	COG0444	Belongs to the ABC transporter superfamily
AciPR4_3506	COG1752	Esterase of the alpha-beta hydrolase superfamily
AciPR4_3507	COG0792	nuclease activity
AciPR4_3511	COG3250	beta-galactosidase activity
AciPR4_3519	COG0859	PFAM glycosyl transferase family 9
AciPR4_3522	COG0438	transferase activity, transferring glycosyl groups
AciPR4_3524	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AciPR4_3525	COG0154	amidase activity
AciPR4_3529	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AciPR4_3531	COG1199	ATP-dependent helicase activity
AciPR4_3535	COG1297	OPT oligopeptide transporter protein
AciPR4_3538	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AciPR4_3539	COG0571	ribonuclease III activity
AciPR4_3540	COG0681	Belongs to the peptidase S26 family
AciPR4_3541	COG0681	Belongs to the peptidase S26 family
AciPR4_3542	COG0681	Belongs to the peptidase S26 family
AciPR4_3545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AciPR4_3549	COG3279	Response regulator of the LytR AlgR family
AciPR4_3552	COG3961	Belongs to the TPP enzyme family
AciPR4_3555	COG2897	thiosulfate sulfurtransferase activity
AciPR4_3556	COG0450	alkyl hydroperoxide reductase
AciPR4_3562	COG0303	'Molybdopterin
AciPR4_3564	COG0577	efflux transmembrane transporter activity
AciPR4_3564	COG1136	(ABC) transporter
AciPR4_3566	COG2318	DinB family
AciPR4_3568	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AciPR4_3572	COG0788	formyltetrahydrofolate deformylase activity
AciPR4_3573	COG0602	queuosine metabolic process
AciPR4_3574	COG0720	synthase
AciPR4_3579	COG1201	RNA secondary structure unwinding
AciPR4_3585	COG0583	DNA-binding transcription factor activity
AciPR4_3590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AciPR4_3599	COG3459	Glycosyltransferase 36 associated
AciPR4_3604	COG3403	YqcI/YcgG family
AciPR4_3605	COG4206	TonB-dependent receptor
AciPR4_3606	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AciPR4_3611	COG1309	transcriptional regulator
AciPR4_3612	COG2207	Transcriptional regulator
AciPR4_3612	COG0662	Cupin 2, conserved barrel domain protein
AciPR4_3613	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AciPR4_3615	COG1309	transcriptional regulator
AciPR4_3619	COG1819	glycosyl
AciPR4_3623	COG1595	DNA-templated transcription, initiation
AciPR4_3627	COG1191	sigma factor activity
AciPR4_3631	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AciPR4_3634	COG0584	glycerophosphoryl diester phosphodiesterase
AciPR4_3637	COG0475	glutathione-regulated potassium exporter activity
AciPR4_3638	COG0175	sulfate reduction
AciPR4_3639	COG2895	sulfate adenylyltransferase (ATP) activity
AciPR4_3640	COG0175	sulfate reduction
AciPR4_3642	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AciPR4_3643	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AciPR4_3644	COG0477	Major facilitator Superfamily
AciPR4_3648	COG1595	DNA-templated transcription, initiation
AciPR4_3653	COG3300	MHYT domain
AciPR4_3653	COG5001	Diguanylate cyclase
AciPR4_3655	COG0577	efflux transmembrane transporter activity
AciPR4_3658	COG1136	(ABC) transporter
AciPR4_3658	COG0577	efflux transmembrane transporter activity
AciPR4_3661	COG1215	transferase activity, transferring glycosyl groups
AciPR4_3663	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AciPR4_3668	COG0673	inositol 2-dehydrogenase activity
AciPR4_3676	COG0481	GTPase activity
AciPR4_3677	COG3942	CHAP domain
AciPR4_3677	COG1388	LysM domain
AciPR4_3679	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AciPR4_3684	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AciPR4_3690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AciPR4_3694	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AciPR4_3696	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AciPR4_3702	COG0110	maltose O-acetyltransferase activity
AciPR4_3707	COG2207	Transcriptional regulator
AciPR4_3709	COG2267	carboxylic ester hydrolase activity
AciPR4_3710	COG4804	nuclease activity
AciPR4_3712	COG1902	pentaerythritol trinitrate reductase activity
AciPR4_3720	COG0583	DNA-binding transcription factor activity
AciPR4_3721	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AciPR4_3722	COG0251	oxidation-reduction process
AciPR4_3723	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AciPR4_3725	COG0583	DNA-binding transcription factor activity
AciPR4_3729	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AciPR4_3730	COG2226	methyltransferase
AciPR4_3735	COG0596	Alpha beta hydrolase
AciPR4_3738	COG2094	Belongs to the DNA glycosylase MPG family
AciPR4_3743	COG1475	DNA binding
AciPR4_3754	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AciPR4_3756	COG0420	3'-5' exonuclease activity
AciPR4_3764	COG4962	Type ii secretion system protein e
AciPR4_3783	COG2826	transposase and inactivated derivatives, IS30 family
AciPR4_3785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AciPR4_3786	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AciPR4_3787	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AciPR4_3788	COG0557	exoribonuclease II activity
AciPR4_3789	COG0673	inositol 2-dehydrogenase activity
AciPR4_3791	COG1215	transferase activity, transferring glycosyl groups
AciPR4_3792	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AciPR4_3793	COG3594	Acyltransferase
AciPR4_3796	COG0823	Involved in the tonB-independent uptake of proteins
AciPR4_3796	COG1506	peptidase
AciPR4_3799	COG0358	DNA primase activity
AciPR4_3802	COG0859	PFAM glycosyl transferase family 9
AciPR4_3803	COG1663	tetraacyldisaccharide 4'-kinase activity
AciPR4_3804	COG1519	Transferase
AciPR4_3808	COG0756	dUTP diphosphatase activity
AciPR4_3809	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AciPR4_3810	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AciPR4_3811	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AciPR4_3815	COG0151	Belongs to the GarS family
AciPR4_3816	COG1914	H( )-stimulated, divalent metal cation uptake system
AciPR4_3819	COG0251	oxidation-reduction process
AciPR4_3821	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AciPR4_3825	COG0644	oxidoreductase
AciPR4_3827	COG1309	transcriptional regulator
AciPR4_3828	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_3829	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AciPR4_3830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AciPR4_3833	COG1501	Belongs to the glycosyl hydrolase 31 family
AciPR4_3837	COG0673	inositol 2-dehydrogenase activity
AciPR4_3847	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AciPR4_3851	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AciPR4_3852	COG2197	response regulator
AciPR4_3853	COG4585	Histidine kinase
AciPR4_3855	COG1131	(ABC) transporter
AciPR4_3858	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AciPR4_3860	COG2814	Major facilitator Superfamily
AciPR4_3862	COG0412	Dienelactone hydrolase
AciPR4_3863	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AciPR4_3865	COG0159	tryptophan synthase activity
AciPR4_3866	COG0133	tryptophan synthase activity
AciPR4_3870	COG3474	cytochrome
AciPR4_3875	COG0135	phosphoribosylanthranilate isomerase activity
AciPR4_3876	COG0134	indole-3-glycerol-phosphate synthase activity
AciPR4_3878	COG0745	RESPONSE REGULATOR receiver
AciPR4_3882	COG0860	N-Acetylmuramoyl-L-alanine amidase
AciPR4_3883	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AciPR4_3884	COG3706	GGDEF domain
AciPR4_3894	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AciPR4_3896	COG2226	methyltransferase
AciPR4_3899	COG0577	efflux transmembrane transporter activity
AciPR4_3899	COG1136	(ABC) transporter
AciPR4_3906	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AciPR4_3907	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AciPR4_3908	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AciPR4_3909	COG0386	Belongs to the glutathione peroxidase family
AciPR4_3911	COG1278	Cold shock
AciPR4_3912	COG3132	Protein of unknown function, DUF480
AciPR4_3918	COG0673	inositol 2-dehydrogenase activity
AciPR4_3922	COG1136	(ABC) transporter
AciPR4_3922	COG0577	efflux transmembrane transporter activity
AciPR4_3924	COG3108	Peptidase M15
AciPR4_3937	COG0753	catalase activity
AciPR4_3938	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_3941	COG0359	binds to the 23S rRNA
AciPR4_3943	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AciPR4_3944	COG0360	Binds together with S18 to 16S ribosomal RNA
AciPR4_3945	COG0193	aminoacyl-tRNA hydrolase activity
AciPR4_3946	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AciPR4_3947	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AciPR4_3948	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AciPR4_3951	COG0542	response to heat
AciPR4_3957	COG2890	protein-(glutamine-N5) methyltransferase activity
AciPR4_3958	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AciPR4_3961	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_3963	COG1793	dna ligase
AciPR4_3964	COG0531	amino acid
AciPR4_3965	COG4206	TonB-dependent receptor
AciPR4_3966	COG0667	Aldo Keto reductase
AciPR4_3969	COG0633	Ferredoxin
AciPR4_3973	COG2826	transposase and inactivated derivatives, IS30 family
AciPR4_3978	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AciPR4_3983	COG0233	cytoplasmic translational termination
AciPR4_3987	COG0243	molybdopterin cofactor binding
AciPR4_3988	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AciPR4_3990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AciPR4_3992	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AciPR4_4007	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AciPR4_4008	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AciPR4_4009	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AciPR4_4012	COG0676	glucose-6-phosphate 1-epimerase activity
AciPR4_4013	COG0424	maF-like protein
AciPR4_4019	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AciPR4_4021	COG1231	oxidoreductase activity
AciPR4_4023	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AciPR4_4026	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AciPR4_4028	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AciPR4_4031	COG0343	queuine tRNA-ribosyltransferase activity
AciPR4_4034	COG1862	Preprotein translocase
AciPR4_4035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AciPR4_4036	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AciPR4_4039	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AciPR4_4040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AciPR4_4047	COG0437	4 iron, 4 sulfur cluster binding
AciPR4_4049	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AciPR4_4054	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AciPR4_4056	COG1136	(ABC) transporter
AciPR4_4056	COG0577	efflux transmembrane transporter activity
AciPR4_4057	COG0577	efflux transmembrane transporter activity
AciPR4_4057	COG1136	(ABC) transporter
AciPR4_4070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AciPR4_4073	COG2070	2-Nitropropane dioxygenase
AciPR4_4076	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AciPR4_4077	COG2378	regulation of single-species biofilm formation
AciPR4_4080	COG0305	Participates in initiation and elongation during chromosome replication
AciPR4_4082	COG0445	tRNA wobble uridine modification
AciPR4_4085	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_4091	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AciPR4_4092	COG1733	regulation of RNA biosynthetic process
AciPR4_4096	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AciPR4_4097	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AciPR4_4098	COG1473	amidohydrolase
AciPR4_4104	COG0583	DNA-binding transcription factor activity
AciPR4_4106	COG0799	negative regulation of ribosome biogenesis
AciPR4_4108	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AciPR4_4109	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AciPR4_4111	COG2124	cytochrome p450
AciPR4_4112	COG2124	cytochrome p450
AciPR4_4114	COG2814	Major facilitator Superfamily
AciPR4_4125	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AciPR4_4130	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AciPR4_4134	COG4221	oxidoreductase activity
AciPR4_4137	COG0564	pseudouridine synthase activity
AciPR4_4140	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_4143	COG0583	DNA-binding transcription factor activity
AciPR4_4152	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AciPR4_4153	COG0357	Ribosomal RNA small subunit methyltransferase G
AciPR4_4154	COG1192	Involved in chromosome partitioning
AciPR4_4155	COG1475	DNA binding
AciPR4_4161	COG1136	(ABC) transporter
AciPR4_4161	COG0577	efflux transmembrane transporter activity
AciPR4_4162	COG0776	regulation of translation
AciPR4_4164	COG2755	lipolytic protein G-D-S-L family
AciPR4_4164	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AciPR4_4165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AciPR4_4166	COG0583	DNA-binding transcription factor activity
AciPR4_4167	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AciPR4_4168	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AciPR4_4173	COG3240	lipase activity
AciPR4_4175	COG0432	Pfam Uncharacterised protein family UPF0047
AciPR4_4177	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AciPR4_4184	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AciPR4_4185	COG4191	Histidine kinase
AciPR4_4194	COG3706	GGDEF domain
AciPR4_4196	COG4191	Histidine kinase
AciPR4_4197	COG1063	alcohol dehydrogenase
AciPR4_4199	COG0673	inositol 2-dehydrogenase activity
AciPR4_4204	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AciPR4_4211	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AciPR4_4214	COG1028	Short-chain dehydrogenase reductase Sdr
AciPR4_4215	COG2207	Transcriptional regulator
AciPR4_4216	COG0793	Belongs to the peptidase S41A family
AciPR4_4218	COG0577	efflux transmembrane transporter activity
AciPR4_4220	COG1309	transcriptional regulator
AciPR4_4224	COG0592	DNA-directed DNA polymerase activity
AciPR4_4232	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
AciPR4_4234	COG2271	Major facilitator Superfamily
AciPR4_4235	COG0632	four-way junction helicase activity
AciPR4_4238	COG0366	Alpha amylase catalytic
AciPR4_4239	COG1070	Carbohydrate kinase
AciPR4_4244	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AciPR4_4248	COG2814	Major facilitator Superfamily
AciPR4_4249	COG0583	DNA-binding transcription factor activity
AciPR4_4252	COG1538	Outer membrane efflux protein
AciPR4_4254	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AciPR4_4255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AciPR4_4256	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AciPR4_4258	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AciPR4_4262	COG2205	protein histidine kinase activity
AciPR4_4263	COG2205	protein histidine kinase activity
AciPR4_4274	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AciPR4_4277	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AciPR4_4279	COG0230	Belongs to the bacterial ribosomal protein bL34 family