locus-tag	class	description
L0P85_00005	COG1982	Orn Lys Arg decarboxylase major
L0P85_00015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L0P85_00020	COG1774	PSP1 C-terminal conserved region
L0P85_00025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L0P85_00030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L0P85_00040	COG1522	sequence-specific DNA binding
L0P85_00045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L0P85_00055	COG0700	Nucleoside recognition
L0P85_00065	COG0084	hydrolase, TatD family'
L0P85_00075	COG1725	Transcriptional regulator
L0P85_00080	COG1131	(ABC) transporter
L0P85_00130	COG0644	oxidoreductase
L0P85_00160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L0P85_00165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L0P85_00195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L0P85_00200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L0P85_00205	COG2088	sporulation resulting in formation of a cellular spore
L0P85_00210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L0P85_00215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L0P85_00235	COG0193	aminoacyl-tRNA hydrolase activity
L0P85_00240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L0P85_00250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L0P85_00255	COG2002	toxin-antitoxin pair type II binding
L0P85_00265	COG3956	TIGRFAM MazG family protein
L0P85_00270	COG0776	regulation of translation
L0P85_00275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L0P85_00295	COG0248	Ppx GppA phosphatase
L0P85_00295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L0P85_00300	COG2208	phosphoserine phosphatase activity
L0P85_00305	COG1164	Oligoendopeptidase f
L0P85_00310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L0P85_00315	COG1494	fructose-1,6-bisphosphatase
L0P85_00320	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L0P85_00325	COG0254	rRNA binding
L0P85_00330	COG1435	thymidine kinase activity
L0P85_00335	COG3872	metal-dependent enzyme
L0P85_00340	COG2890	protein-(glutamine-N5) methyltransferase activity
L0P85_00345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L0P85_00355	COG0009	L-threonylcarbamoyladenylate synthase
L0P85_00360	COG0698	ribose 5-phosphate isomerase
L0P85_00365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L0P85_00390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L0P85_00395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L0P85_00405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L0P85_00415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L0P85_00420	COG0736	holo-[acyl-carrier-protein] synthase activity
L0P85_00440	COG3959	Transketolase, thiamine diphosphate binding domain
L0P85_00445	COG3958	Transketolase
L0P85_00455	COG0840	transmembrane signaling receptor activity
L0P85_00460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L0P85_00465	COG3409	Peptidoglycan-binding domain 1 protein
L0P85_00465	COG0793	Belongs to the peptidase S41A family
L0P85_00475	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L0P85_00480	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
L0P85_00485	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L0P85_00495	COG1454	alcohol dehydrogenase
L0P85_00510	COG0210	DNA helicase
L0P85_00515	COG1362	aminopeptidase activity
L0P85_00520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L0P85_00525	COG1227	inorganic diphosphatase activity
L0P85_00550	COG2357	RelA SpoT domain protein
L0P85_00580	COG0303	'Molybdopterin
L0P85_00585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L0P85_00600	COG0521	Mo-molybdopterin cofactor biosynthetic process
L0P85_00605	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L0P85_00610	COG2116	formate transmembrane transporter activity
L0P85_00615	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L0P85_00615	COG0493	'glutamate synthase
L0P85_00625	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L0P85_00635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L0P85_00640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L0P85_00645	COG1660	Displays ATPase and GTPase activities
L0P85_00660	COG1481	regulation of sporulation
L0P85_00670	COG0205	6-phosphofructokinase activity
L0P85_00680	COG0733	neurotransmitter:sodium symporter activity
L0P85_00705	COG0426	domain, Protein
L0P85_00710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L0P85_00715	COG4106	trans-aconitate 2-methyltransferase activity
L0P85_00745	COG1151	hydroxylamine reductase activity
L0P85_00780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L0P85_00795	COG0544	peptidyl-prolyl cis-trans isomerase activity
L0P85_00800	COG0740	serine-type endopeptidase activity
L0P85_00805	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L0P85_00810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L0P85_00815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L0P85_00820	COG0835	chemotaxis
L0P85_00820	COG0784	Response regulator, receiver
L0P85_00830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L0P85_00835	COG1459	type II secretion system
L0P85_00865	COG1405	negative regulation of cell septum assembly
L0P85_00865	COG3012	SEC-C Motif Domain Protein
L0P85_00875	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
L0P85_00885	COG0166	Belongs to the GPI family
L0P85_00890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L0P85_00925	COG0668	transmembrane transport
L0P85_00930	COG1285	pathogenesis
L0P85_00935	COG1164	Oligoendopeptidase f
L0P85_00950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L0P85_00960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L0P85_00965	COG0573	inorganic phosphate transmembrane transporter activity
L0P85_00970	COG0581	inorganic phosphate transmembrane transporter activity
L0P85_00975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L0P85_00980	COG0704	Plays a role in the regulation of phosphate uptake
L0P85_00995	COG0726	polysaccharide deacetylase
L0P85_01030	COG0726	polysaccharide deacetylase
L0P85_01045	COG3829	transcription factor binding
L0P85_01050	COG3681	Belongs to the UPF0597 family
L0P85_01055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L0P85_01070	COG1380	Effector of murein hydrolase LrgA
L0P85_01080	COG2171	N-acyltransferase activity
L0P85_01085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L0P85_01095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L0P85_01100	COG1760	l-serine dehydratase
L0P85_01110	COG0577	efflux transmembrane transporter activity
L0P85_01110	COG1136	(ABC) transporter
L0P85_01120	COG1473	amidohydrolase
L0P85_01130	COG2226	methyltransferase
L0P85_01135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L0P85_01140	COG1725	Transcriptional regulator
L0P85_01145	COG1131	(ABC) transporter
L0P85_01180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L0P85_01195	COG1126	abc transporter atp-binding protein
L0P85_01200	COG1115	amino acid carrier protein
L0P85_01205	COG0584	glycerophosphoryl diester phosphodiesterase
L0P85_01210	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L0P85_01230	COG2390	Transcriptional regulator
L0P85_01240	COG0126	phosphoglycerate kinase activity
L0P85_01250	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L0P85_01255	COG0148	phosphopyruvate hydratase activity
L0P85_01265	COG1609	Transcriptional regulator
L0P85_01270	COG1960	acyl-CoA dehydrogenase activity
L0P85_01275	COG2086	electron transfer activity
L0P85_01280	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L0P85_01285	COG1607	acyl-coa hydrolase
L0P85_01290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L0P85_01290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L0P85_01310	COG0557	exoribonuclease II activity
L0P85_01325	COG1876	peptidase activity
L0P85_01340	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L0P85_01350	COG1136	(ABC) transporter
L0P85_01355	COG0577	efflux transmembrane transporter activity
L0P85_01360	COG0745	RESPONSE REGULATOR receiver
L0P85_01365	COG2205	protein histidine kinase activity
L0P85_01370	COG0601	transmembrane transport
L0P85_01375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L0P85_01380	COG0444	Belongs to the ABC transporter superfamily
L0P85_01385	COG4608	Belongs to the ABC transporter superfamily
L0P85_01415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L0P85_01435	COG3209	COG3209 Rhs family protein
L0P85_01445	COG3209	COG3209 Rhs family protein
L0P85_01475	COG2252	PERMEase
L0P85_01485	COG2207	Transcriptional regulator
L0P85_01485	COG3708	Transcriptional regulator
L0P85_01495	COG0745	RESPONSE REGULATOR receiver
L0P85_01500	COG2205	protein histidine kinase activity
L0P85_01500	COG0784	Response regulator, receiver
L0P85_01505	COG0577	efflux transmembrane transporter activity
L0P85_01510	COG1136	(ABC) transporter
L0P85_01515	COG3716	PTS system mannose fructose sorbose family IID component
L0P85_01520	COG3715	PTS system
L0P85_01525	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L0P85_01540	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0P85_01545	COG2222	sugar isomerase
L0P85_01565	COG1105	Belongs to the carbohydrate kinase PfkB family
L0P85_01570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L0P85_01575	COG2011	ABC-type metal ion transport system permease component
L0P85_01600	COG3842	ATPase activity
L0P85_01610	COG0395	ABC-type sugar transport system, permease component
L0P85_01615	COG1653	transport
L0P85_01620	COG1131	(ABC) transporter
L0P85_01655	COG5002	protein histidine kinase activity
L0P85_01660	COG0745	RESPONSE REGULATOR receiver
L0P85_01690	COG3314	Sporulation integral membrane protein YlbJ
L0P85_01695	COG0039	L-malate dehydrogenase activity
L0P85_01700	COG1414	Transcriptional regulator
L0P85_01710	COG5002	protein histidine kinase activity
L0P85_01720	COG1846	Transcriptional regulator
L0P85_01725	COG0386	Belongs to the glutathione peroxidase family
L0P85_01735	COG3118	belongs to the thioredoxin family
L0P85_01740	COG0745	RESPONSE REGULATOR receiver
L0P85_01745	COG2205	protein histidine kinase activity
L0P85_01750	COG2205	protein histidine kinase activity
L0P85_01790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_01795	COG1120	ATPase activity
L0P85_01800	COG0736	holo-[acyl-carrier-protein] synthase activity
L0P85_01805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L0P85_01820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L0P85_01825	COG1028	Short-chain dehydrogenase reductase Sdr
L0P85_01830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L0P85_01835	COG0511	ligase activity, forming carbon-carbon bonds
L0P85_01845	COG0439	Biotin carboxylase
L0P85_01855	COG0825	malonyl-CoA metabolic process
L0P85_01875	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
L0P85_01885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L0P85_01890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L0P85_01925	COG1174	glycine betaine transport
L0P85_01935	COG0517	IMP dehydrogenase activity
L0P85_01935	COG1125	glycine betaine transport
L0P85_01940	COG1959	2 iron, 2 sulfur cluster binding
L0P85_01945	COG1592	Rubrerythrin
L0P85_01945	COG1773	rubredoxin
L0P85_01960	COG0534	Mate efflux family protein
L0P85_01980	COG0436	Aminotransferase
L0P85_02005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L0P85_02010	COG0789	Transcriptional regulator
L0P85_02025	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L0P85_02030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L0P85_02045	COG0745	RESPONSE REGULATOR receiver
L0P85_02045	COG2205	protein histidine kinase activity
L0P85_02045	COG3292	Two component regulator propeller
L0P85_02075	COG1215	transferase activity, transferring glycosyl groups
L0P85_02095	COG3949	Membrane
L0P85_02100	COG0583	DNA-binding transcription factor activity
L0P85_02110	COG0583	DNA-binding transcription factor activity
L0P85_02115	COG0569	domain protein
L0P85_02115	COG2985	domain, Protein
L0P85_02120	COG0427	acetyl-CoA hydrolase
L0P85_02125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L0P85_02125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L0P85_02130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L0P85_02130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L0P85_02155	COG4770	biotin carboxylase activity
L0P85_02160	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
L0P85_02165	COG1131	(ABC) transporter
L0P85_02185	COG0745	RESPONSE REGULATOR receiver
L0P85_02195	COG2205	protein histidine kinase activity
L0P85_02200	COG1136	(ABC) transporter
L0P85_02205	COG0577	efflux transmembrane transporter activity
L0P85_02215	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L0P85_02225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L0P85_02230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L0P85_02240	COG0745	RESPONSE REGULATOR receiver
L0P85_02255	COG2205	protein histidine kinase activity
L0P85_02260	COG0367	asparagine synthase
L0P85_02270	COG1476	TRANSCRIPTIONal
L0P85_02275	COG0157	Belongs to the NadC ModD family
L0P85_02285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L0P85_02290	COG1827	regulation of RNA biosynthetic process
L0P85_02295	COG3275	phosphorelay sensor kinase activity
L0P85_02300	COG3279	Response regulator of the LytR AlgR family
L0P85_02305	COG1966	Carbon starvation protein
L0P85_02310	COG4978	Transcriptional regulator
L0P85_02310	COG0789	Transcriptional regulator
L0P85_02350	COG1122	ATPase activity
L0P85_02355	COG1492	cobalamin metabolic process
L0P85_02360	COG1797	cobyrinic acid a,c-diamide synthase activity
L0P85_02370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L0P85_02385	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
L0P85_02430	COG0181	hydroxymethylbilane synthase activity
L0P85_02440	COG0113	porphobilinogen synthase activity
L0P85_02450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L0P85_02450	COG1648	precorrin-2 dehydrogenase activity
L0P85_02455	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L0P85_02470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L0P85_02485	COG1114	Component of the transport system for branched-chain amino acids
L0P85_02530	COG1472	Belongs to the glycosyl hydrolase 3 family
L0P85_02540	COG0641	radical SAM
L0P85_02585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L0P85_02590	COG0573	inorganic phosphate transmembrane transporter activity
L0P85_02595	COG0581	inorganic phosphate transmembrane transporter activity
L0P85_02600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L0P85_02605	COG0704	Plays a role in the regulation of phosphate uptake
L0P85_02610	COG1950	PFAM Membrane protein of
L0P85_02625	COG3118	belongs to the thioredoxin family
L0P85_02675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0P85_02675	COG3711	transcriptional antiterminator
L0P85_02685	COG3730	PTS system glucitol sorbitol-specific
L0P85_02690	COG3732	PTS system glucitol sorbitol-specific
L0P85_02700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L0P85_02705	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L0P85_02710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L0P85_02720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L0P85_02725	COG1846	Transcriptional regulator
L0P85_02740	COG4978	Transcriptional regulator
L0P85_02740	COG0789	Transcriptional regulator
L0P85_02745	COG0622	Phosphoesterase
L0P85_02750	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_02755	COG4605	iron ion homeostasis
L0P85_02760	COG4604	ABC transporter, ATP-binding protein
L0P85_02765	COG4607	ABC-type enterochelin transport system periplasmic component
L0P85_02775	COG2078	PFAM AMMECR1 domain protein
L0P85_02775	COG3885	ferrous iron binding
L0P85_02785	COG1609	Transcriptional regulator
L0P85_02790	COG1940	carbohydrate kinase activity
L0P85_02830	COG3118	belongs to the thioredoxin family
L0P85_02850	COG2116	formate transmembrane transporter activity
L0P85_02875	COG1132	(ABC) transporter
L0P85_02885	COG2059	Chromate
L0P85_02895	COG1489	DNA binding
L0P85_02900	COG0539	negative regulation of cytoplasmic translation
L0P85_02905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L0P85_02915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L0P85_02925	COG0628	permease
L0P85_02935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L0P85_02950	COG2301	Belongs to the HpcH HpaI aldolase family
L0P85_02955	COG3051	citrate lyase alpha subunit
L0P85_02975	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
L0P85_02985	COG1802	Transcriptional regulator
L0P85_03000	COG5016	pyruvate
L0P85_03000	COG0511	ligase activity, forming carbon-carbon bonds
L0P85_03005	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
L0P85_03050	COG0786	glutamate:sodium symporter activity
L0P85_03055	COG0670	Belongs to the BI1 family
L0P85_03060	COG3706	GGDEF domain
L0P85_03065	COG1744	ABC transporter substrate-binding protein PnrA-like
L0P85_03075	COG1131	(ABC) transporter
L0P85_03110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L0P85_03115	COG1116	anion transmembrane transporter activity
L0P85_03125	COG0006	proline dipeptidase activity
L0P85_03130	COG1263	PTS System
L0P85_03130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L0P85_03140	COG1737	Transcriptional regulator
L0P85_03150	COG3711	transcriptional antiterminator
L0P85_03150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0P85_03155	COG3414	Phosphotransferase system galactitol-specific IIB component
L0P85_03160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0P85_03165	COG3775	system Galactitol-specific IIC component
L0P85_03190	COG2310	stress, protein
L0P85_03205	COG3853	Toxic anion resistance protein (TelA)
L0P85_03245	COG0579	oxidoreductase
L0P85_03270	COG2814	Major facilitator Superfamily
L0P85_03280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L0P85_03295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L0P85_03310	COG0842	Transport permease protein
L0P85_03310	COG1511	domain protein
L0P85_03315	COG1309	transcriptional regulator
L0P85_03345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L0P85_03350	COG3279	Response regulator of the LytR AlgR family
L0P85_03355	COG3290	protein histidine kinase activity
L0P85_03365	COG1136	(ABC) transporter
L0P85_03385	COG1533	DNA photolyase activity
L0P85_03395	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L0P85_03405	COG0281	malic enzyme
L0P85_03440	COG0572	uridine kinase
L0P85_03455	COG1136	(ABC) transporter
L0P85_03490	COG1476	TRANSCRIPTIONal
L0P85_03495	COG3842	ATPase activity
L0P85_03505	COG1177	transmembrane transport
L0P85_03510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L0P85_03530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L0P85_03530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0P85_03530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L0P85_03575	COG1288	antiporter activity
L0P85_03580	COG2195	Cleaves the N-terminal amino acid of tripeptides
L0P85_03585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L0P85_03590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L0P85_03595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L0P85_03620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L0P85_03635	COG0438	transferase activity, transferring glycosyl groups
L0P85_03640	COG1216	Glycosyl transferase, family 2
L0P85_03640	COG1442	glycosyl transferase family 8
L0P85_03660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L0P85_03685	COG1408	metallophosphoesterase
L0P85_03700	COG0728	peptidoglycan biosynthetic process
L0P85_03745	COG1132	(ABC) transporter
L0P85_03775	COG4935	Belongs to the peptidase S8 family
L0P85_03775	COG2234	aminopeptidase activity
L0P85_03780	COG1316	TRANSCRIPTIONal
L0P85_03820	COG0681	Belongs to the peptidase S26 family
L0P85_03835	COG5002	protein histidine kinase activity
L0P85_03840	COG2204	response regulator
L0P85_03895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L0P85_03905	COG1408	metallophosphoesterase
L0P85_03910	COG3944	biosynthesis protein
L0P85_03915	COG0489	protein tyrosine kinase activity
L0P85_03920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L0P85_03925	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L0P85_03930	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L0P85_03955	COG2327	Polysaccharide pyruvyl transferase
L0P85_03960	COG0728	peptidoglycan biosynthetic process
L0P85_03965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L0P85_03970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L0P85_03995	COG1297	OPT oligopeptide transporter protein
L0P85_04020	COG1316	TRANSCRIPTIONal
L0P85_04060	COG1376	ErfK ybiS ycfS ynhG family protein
L0P85_04075	COG0740	serine-type endopeptidase activity
L0P85_04090	COG3706	GGDEF domain
L0P85_04105	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L0P85_04110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_04115	COG1120	ATPase activity
L0P85_04120	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
L0P85_04130	COG1429	ligase activity, forming nitrogen-metal bonds
L0P85_04150	COG0446	pyridine nucleotide-disulphide oxidoreductase
L0P85_04165	COG0489	protein tyrosine kinase activity
L0P85_04205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L0P85_04210	COG0028	Belongs to the TPP enzyme family
L0P85_04225	COG1307	EDD domain protein, DegV family
L0P85_04230	COG1272	protein, Hemolysin III
L0P85_04245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L0P85_04255	COG0328	RNA-DNA hybrid ribonuclease activity
L0P85_04255	COG3341	Caulimovirus viroplasmin
L0P85_04260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L0P85_04265	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L0P85_04270	COG0671	phosphoesterase, PA-phosphatase related
L0P85_04275	COG2081	HI0933 family
L0P85_04285	COG1971	Probably functions as a manganese efflux pump
L0P85_04320	COG3829	transcription factor binding
L0P85_04325	COG3804	dihydrodipicolinate reductase
L0P85_04345	COG5012	cobalamin binding
L0P85_04355	COG3457	Alanine racemase
L0P85_04360	COG1115	amino acid carrier protein
L0P85_04365	COG4187	Peptidase family M20/M25/M40
L0P85_04370	COG1757	Na H antiporter
L0P85_04375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L0P85_04385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L0P85_04390	COG4869	propanediol catabolic process
L0P85_04395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L0P85_04440	COG1918	ferrous iron import across plasma membrane
L0P85_04445	COG1918	ferrous iron import across plasma membrane
L0P85_04445	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L0P85_04455	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
L0P85_04460	COG0741	lytic transglycosylase activity
L0P85_04485	COG1256	bacterial-type flagellum assembly
L0P85_04485	COG4786	Flagellar basal body rod
L0P85_04495	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
L0P85_04510	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
L0P85_04520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L0P85_04525	COG0457	Tetratricopeptide repeat
L0P85_04525	COG0463	Glycosyl transferase, family 2
L0P85_04555	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L0P85_04560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L0P85_04635	COG1677	Flagellar hook-basal body complex protein FliE
L0P85_04640	COG1766	The M ring may be actively involved in energy transduction
L0P85_04645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L0P85_04655	COG1157	protein secretion by the type III secretion system
L0P85_04675	COG4786	Flagellar basal body rod
L0P85_04680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L0P85_04685	COG1360	Flagellar Motor Protein
L0P85_04695	COG1338	Plays a role in the flagellum-specific transport system
L0P85_04705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L0P85_04710	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L0P85_04715	COG1191	sigma factor activity
L0P85_04720	COG4786	Flagellar basal body rod
L0P85_04735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L0P85_04735	COG1776	CheC inhibitor of MCP methylation
L0P85_04750	COG0840	transmembrane signaling receptor activity
L0P85_04755	COG2198	Histidine kinase
L0P85_04755	COG0643	Histidine kinase
L0P85_04760	COG2201	protein-glutamate methylesterase activity
L0P85_04765	COG1776	CheC inhibitor of MCP methylation
L0P85_04770	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
L0P85_04775	COG0835	chemotaxis
L0P85_04785	COG2201	protein-glutamate methylesterase activity
L0P85_04795	COG1794	racemase activity, acting on amino acids and derivatives
L0P85_04825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L0P85_04835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L0P85_04835	COG3608	succinylglutamate desuccinylase aspartoacylase
L0P85_04840	COG2068	MobA-Related Protein
L0P85_04845	COG1104	cysteine desulfurase activity
L0P85_04855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L0P85_04860	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L0P85_04880	COG2202	Pas domain
L0P85_04880	COG2205	protein histidine kinase activity
L0P85_04890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_04895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_04905	COG0534	Mate efflux family protein
L0P85_04910	COG0601	transmembrane transport
L0P85_04915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L0P85_04920	COG0444	Belongs to the ABC transporter superfamily
L0P85_04925	COG4608	Belongs to the ABC transporter superfamily
L0P85_04930	COG4166	transmembrane transport
L0P85_04965	COG1151	hydroxylamine reductase activity
L0P85_04975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L0P85_04985	COG2972	Histidine kinase
L0P85_04990	COG2207	Transcriptional regulator
L0P85_04990	COG4753	response regulator
L0P85_04995	COG1744	ABC transporter substrate-binding protein PnrA-like
L0P85_05000	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L0P85_05015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L0P85_05040	COG0302	gtp cyclohydrolase
L0P85_05045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L0P85_05050	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L0P85_05055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L0P85_05060	COG0534	Mate efflux family protein
L0P85_05065	COG1937	Protein conserved in bacteria
L0P85_05070	COG1388	LysM domain
L0P85_05070	COG3584	3D domain protein
L0P85_05075	COG1114	Component of the transport system for branched-chain amino acids
L0P85_05080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L0P85_05100	COG1376	ErfK ybiS ycfS ynhG family protein
L0P85_05105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L0P85_05110	COG1215	transferase activity, transferring glycosyl groups
L0P85_05115	COG0791	NLP P60 protein
L0P85_05130	COG0860	N-Acetylmuramoyl-L-alanine amidase
L0P85_05145	COG3546	catalase activity
L0P85_05160	COG0037	tRNA processing
L0P85_05165	COG2176	DNA-directed DNA polymerase activity
L0P85_05180	COG1404	Belongs to the peptidase S8 family
L0P85_05185	COG2884	Cell division ATP-binding protein ftsE
L0P85_05190	COG2177	Part of the ABC transporter FtsEX involved in
L0P85_05195	COG0739	heme binding
L0P85_05200	COG2176	DNA-directed DNA polymerase activity
L0P85_05210	COG0515	serine threonine protein kinase
L0P85_05210	COG2815	serine threonine protein kinase
L0P85_05220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L0P85_05235	COG2364	Membrane
L0P85_05260	COG0436	Aminotransferase
L0P85_05275	COG3875	lactate racemase activity
L0P85_05285	COG2897	thiosulfate sulfurtransferase activity
L0P85_05290	COG1215	transferase activity, transferring glycosyl groups
L0P85_05320	COG0577	efflux transmembrane transporter activity
L0P85_05325	COG1136	(ABC) transporter
L0P85_05335	COG0398	Pfam SNARE associated Golgi protein
L0P85_05345	COG4134	Bacterial extracellular solute-binding protein
L0P85_05350	COG1177	transmembrane transport
L0P85_05360	COG3842	ATPase activity
L0P85_05375	COG2357	RelA SpoT domain protein
L0P85_05385	COG1525	nuclease
L0P85_05395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L0P85_05400	COG1595	DNA-templated transcription, initiation
L0P85_05410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L0P85_05420	COG0583	DNA-binding transcription factor activity
L0P85_05425	COG0778	Nitroreductase
L0P85_05435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L0P85_05440	COG0095	Lipoate-protein ligase
L0P85_05445	COG0656	L-ascorbic acid biosynthetic process
L0P85_05470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0P85_05470	COG3711	transcriptional antiterminator
L0P85_05475	COG1105	Belongs to the carbohydrate kinase PfkB family
L0P85_05480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L0P85_05480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L0P85_05480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0P85_05485	COG2188	Transcriptional regulator
L0P85_05490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L0P85_05495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L0P85_05500	COG1486	melibiose metabolic process
L0P85_05505	COG3394	polysaccharide catabolic process
L0P85_05510	COG1447	Phosphotransferase system cellobiose-specific component IIA
L0P85_05520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L0P85_05525	COG2188	Transcriptional regulator
L0P85_05530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L0P85_05530	COG0723	plastoquinol--plastocyanin reductase activity
L0P85_05535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L0P85_05540	COG0662	Cupin 2, conserved barrel domain protein
L0P85_05575	COG1404	Belongs to the peptidase S8 family
L0P85_05590	COG1404	Belongs to the peptidase S8 family
L0P85_05600	COG1404	Belongs to the peptidase S8 family
L0P85_05605	COG1404	Belongs to the peptidase S8 family
L0P85_05605	COG1404	Belongs to the peptidase S8 family
L0P85_05610	COG4667	esterase of the alpha-beta hydrolase superfamily
L0P85_05650	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
L0P85_05670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L0P85_05675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L0P85_05675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L0P85_05685	COG3584	3D domain protein
L0P85_05685	COG1388	LysM domain
L0P85_05690	COG3584	3D domain protein
L0P85_05690	COG1388	LysM domain
L0P85_05715	COG2720	vancomycin resistance protein
L0P85_05725	COG0628	permease
L0P85_05735	COG1115	amino acid carrier protein
L0P85_05760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L0P85_05770	COG3118	belongs to the thioredoxin family
L0P85_05805	COG1686	Belongs to the peptidase S11 family
L0P85_05810	COG0052	Belongs to the universal ribosomal protein uS2 family
L0P85_05815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L0P85_05820	COG0528	UMP kinase activity
L0P85_05825	COG0233	cytoplasmic translational termination
L0P85_05840	COG4589	Belongs to the CDS family
L0P85_05850	COG2801	Transposase and inactivated derivatives
L0P85_05855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L0P85_05860	COG0750	zinc metalloprotease
L0P85_05885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L0P85_05895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L0P85_05900	COG2011	ABC-type metal ion transport system permease component
L0P85_05905	COG1464	Belongs to the NlpA lipoprotein family
L0P85_05915	COG2094	Belongs to the DNA glycosylase MPG family
L0P85_05920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L0P85_05925	COG4086	secreted protein
L0P85_05935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L0P85_05945	COG0583	DNA-binding transcription factor activity
L0P85_05950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L0P85_05985	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L0P85_06000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L0P85_06005	COG0583	DNA-binding transcription factor activity
L0P85_06020	COG0601	transmembrane transport
L0P85_06025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L0P85_06030	COG1126	abc transporter atp-binding protein
L0P85_06040	COG0484	heat shock protein binding
L0P85_06075	COG0765	amino acid transport
L0P85_06080	COG1126	abc transporter atp-binding protein
L0P85_06085	COG1349	DNA-binding transcription factor activity
L0P85_06090	COG3395	kinase activity
L0P85_06095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L0P85_06100	COG2610	gluconate transmembrane transporter activity
L0P85_06110	COG0626	cystathionine gamma-synthase activity
L0P85_06115	COG1979	alcohol dehydrogenase
L0P85_06120	COG1349	DNA-binding transcription factor activity
L0P85_06125	COG0235	Class ii aldolase
L0P85_06185	COG1609	Transcriptional regulator
L0P85_06195	COG0493	'glutamate synthase
L0P85_06200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L0P85_06200	COG0167	dihydroorotate dehydrogenase activity
L0P85_06220	COG1114	Component of the transport system for branched-chain amino acids
L0P85_06235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L0P85_06265	COG1114	Component of the transport system for branched-chain amino acids
L0P85_06275	COG0038	chloride channel
L0P85_06280	COG0531	amino acid
L0P85_06285	COG3706	GGDEF domain
L0P85_06300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L0P85_06320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L0P85_06320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L0P85_06370	COG0517	IMP dehydrogenase activity
L0P85_06380	COG3339	Conserved Protein
L0P85_06390	COG4326	sporulation control protein
L0P85_06395	COG0517	IMP dehydrogenase activity
L0P85_06445	COG1396	sequence-specific DNA binding
L0P85_06495	COG1129	ABC transporter
L0P85_06510	COG4895	conserved protein (DUF2196)
L0P85_06530	COG1011	Hydrolase
L0P85_06540	COG0789	Transcriptional regulator
L0P85_06540	COG4978	Transcriptional regulator
L0P85_06560	COG1733	regulation of RNA biosynthetic process
L0P85_06565	COG5001	Diguanylate cyclase
L0P85_06565	COG3300	MHYT domain
L0P85_06610	COG3853	Toxic anion resistance protein (TelA)
L0P85_06615	COG3620	sequence-specific DNA binding
L0P85_06640	COG0789	Transcriptional regulator
L0P85_06655	COG5505	Protein of unknown function (DUF819)
L0P85_06665	COG1058	Belongs to the CinA family
L0P85_06665	COG1546	Belongs to the CinA family
L0P85_06670	COG0561	phosphatase activity
L0P85_06680	COG0693	protein deglycase activity
L0P85_06685	COG1357	PFAM Pentapeptide repeats (8 copies)
L0P85_06690	COG3829	transcription factor binding
L0P85_06715	COG1242	4 iron, 4 sulfur cluster binding
L0P85_06725	COG2720	vancomycin resistance protein
L0P85_06730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L0P85_06760	COG1132	(ABC) transporter
L0P85_06770	COG2897	thiosulfate sulfurtransferase activity
L0P85_06780	COG3104	oligopeptide transport
L0P85_06785	COG1404	Belongs to the peptidase S8 family
L0P85_06790	COG4555	ABC transporter
L0P85_06795	COG1668	transmembrane transport
L0P85_06830	COG4978	Transcriptional regulator
L0P85_06830	COG0789	Transcriptional regulator
L0P85_06845	COG0726	polysaccharide deacetylase
L0P85_06850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L0P85_06850	COG1199	ATP-dependent helicase activity
L0P85_06925	COG1396	sequence-specific DNA binding
L0P85_06935	COG3561	AntA/AntB antirepressor
L0P85_06980	COG0629	single-stranded DNA binding
L0P85_07045	COG5484	DNA packaging
L0P85_07195	COG3708	Transcriptional regulator
L0P85_07195	COG2207	Transcriptional regulator
L0P85_07205	COG0450	alkyl hydroperoxide reductase
L0P85_07225	COG2720	vancomycin resistance protein
L0P85_07275	COG2132	Multicopper oxidase
L0P85_07285	COG0358	DNA primase activity
L0P85_07295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L0P85_07300	COG2384	SAM-dependent methyltransferase
L0P85_07305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L0P85_07350	COG1592	Rubrerythrin
L0P85_07350	COG1773	rubredoxin
L0P85_07360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L0P85_07365	COG0154	amidase activity
L0P85_07370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L0P85_07375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L0P85_07380	COG0019	diaminopimelate decarboxylase activity
L0P85_07385	COG0668	transmembrane transport
L0P85_07390	COG0398	Pfam SNARE associated Golgi protein
L0P85_07395	COG0095	Lipoate-protein ligase
L0P85_07405	COG1757	Na H antiporter
L0P85_07410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L0P85_07415	COG1757	Na H antiporter
L0P85_07420	COG1757	Na H antiporter
L0P85_07430	COG1509	lysine 2,3-aminomutase activity
L0P85_07440	COG1454	alcohol dehydrogenase
L0P85_07460	COG0456	acetyltransferase
L0P85_07485	COG1388	LysM domain
L0P85_07485	COG3584	3D domain protein
L0P85_07490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L0P85_07500	COG1295	ribonuclease BN
L0P85_07505	COG0460	homoserine dehydrogenase
L0P85_07515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L0P85_07550	COG0534	Mate efflux family protein
L0P85_07565	COG1393	Belongs to the ArsC family
L0P85_07570	COG1725	Transcriptional regulator
L0P85_07575	COG1131	(ABC) transporter
L0P85_07585	COG0531	amino acid
L0P85_07590	COG0531	amino acid
L0P85_07595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L0P85_07600	COG1606	tRNA processing
L0P85_07605	COG0116	Belongs to the methyltransferase superfamily
L0P85_07625	COG0745	RESPONSE REGULATOR receiver
L0P85_07630	COG5002	protein histidine kinase activity
L0P85_07640	COG0297	glycogen (starch) synthase activity
L0P85_07640	COG0438	transferase activity, transferring glycosyl groups
L0P85_07645	COG0295	cytidine deaminase activity
L0P85_07665	COG1307	EDD domain protein, DegV family
L0P85_07670	COG1773	rubredoxin
L0P85_07675	COG2186	Transcriptional regulator
L0P85_07680	COG1620	l-lactate permease
L0P85_07685	COG3875	lactate racemase activity
L0P85_07700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L0P85_07705	COG0277	FAD linked oxidase domain protein
L0P85_07715	COG1473	amidohydrolase
L0P85_07720	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
L0P85_07725	COG1473	amidohydrolase
L0P85_07735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L0P85_07740	COG1396	sequence-specific DNA binding
L0P85_07755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L0P85_07760	COG3123	guanosine phosphorylase activity
L0P85_07775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L0P85_07795	COG3976	FMN-binding domain protein
L0P85_07795	COG1053	succinate dehydrogenase
L0P85_07805	COG2801	Transposase and inactivated derivatives
L0P85_07820	COG3829	transcription factor binding
L0P85_07825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L0P85_07830	COG1045	serine acetyltransferase
L0P85_07840	COG1053	succinate dehydrogenase
L0P85_07840	COG3976	FMN-binding domain protein
L0P85_07850	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L0P85_07880	COG3655	Transcriptional regulator
L0P85_07890	COG1054	Belongs to the UPF0176 family
L0P85_07895	COG3620	sequence-specific DNA binding
L0P85_07925	COG1309	transcriptional regulator
L0P85_07960	COG1151	hydroxylamine reductase activity
L0P85_07965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L0P85_07970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L0P85_08000	COG4978	Transcriptional regulator
L0P85_08000	COG0789	Transcriptional regulator
L0P85_08040	COG2116	formate transmembrane transporter activity
L0P85_08045	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
L0P85_08050	COG5002	protein histidine kinase activity
L0P85_08060	COG1704	LemA family
L0P85_08065	COG1773	rubredoxin
L0P85_08065	COG1592	Rubrerythrin
L0P85_08070	COG0784	Response regulator, receiver
L0P85_08070	COG2205	protein histidine kinase activity
L0P85_08075	COG0791	NLP P60 protein
L0P85_08090	COG0789	Transcriptional regulator
L0P85_08090	COG4978	Transcriptional regulator
L0P85_08105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L0P85_08145	COG0375	protein maturation
L0P85_08150	COG2323	membrane
L0P85_08155	COG2249	NAD(P)H dehydrogenase (quinone) activity
L0P85_08170	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L0P85_08185	COG2378	regulation of single-species biofilm formation
L0P85_08190	COG0693	protein deglycase activity
L0P85_08220	COG1690	Belongs to the RtcB family
L0P85_08255	COG3620	sequence-specific DNA binding
L0P85_08260	COG1819	glycosyl
L0P85_08285	COG1129	ABC transporter
L0P85_08290	COG1172	Belongs to the binding-protein-dependent transport system permease family
L0P85_08295	COG4213	ABC transporter substrate-binding protein
L0P85_08300	COG2234	aminopeptidase activity
L0P85_08335	COG2604	Protein of unknown function DUF115
L0P85_08355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L0P85_08360	COG1882	Formate acetyltransferase
L0P85_08375	COG0659	secondary active sulfate transmembrane transporter activity
L0P85_08400	COG1686	Belongs to the peptidase S11 family
L0P85_08405	COG5002	protein histidine kinase activity
L0P85_08410	COG5002	protein histidine kinase activity
L0P85_08430	COG0312	modulator of DNA gyrase
L0P85_08435	COG0312	modulator of DNA gyrase
L0P85_08450	COG1733	regulation of RNA biosynthetic process
L0P85_08465	COG0546	phosphoglycolate phosphatase activity
L0P85_08490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L0P85_08495	COG3875	lactate racemase activity
L0P85_08500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L0P85_08505	COG0406	alpha-ribazole phosphatase activity
L0P85_08510	COG3976	FMN-binding domain protein
L0P85_08510	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
L0P85_08525	COG1695	Transcriptional regulator
L0P85_08535	COG0346	lactoylglutathione lyase activity
L0P85_08550	COG0243	molybdopterin cofactor binding
L0P85_08560	COG1132	(ABC) transporter
L0P85_08565	COG1132	(ABC) transporter
L0P85_08590	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
L0P85_08595	COG2155	Conserved Protein
L0P85_08620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L0P85_08640	COG1522	sequence-specific DNA binding
L0P85_08640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L0P85_08645	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
L0P85_08690	COG1115	amino acid carrier protein
L0P85_08695	COG2801	Transposase and inactivated derivatives
L0P85_08705	COG1362	aminopeptidase activity
L0P85_08710	COG1253	flavin adenine dinucleotide binding
L0P85_08730	COG2226	methyltransferase
L0P85_08745	COG1725	Transcriptional regulator
L0P85_08750	COG1131	(ABC) transporter
L0P85_08765	COG0745	RESPONSE REGULATOR receiver
L0P85_08770	COG2205	protein histidine kinase activity
L0P85_08775	COG1136	(ABC) transporter
L0P85_08805	COG0596	Alpha beta hydrolase
L0P85_08810	COG4152	abc transporter atp-binding protein
L0P85_08815	COG1668	transmembrane transport
L0P85_08825	COG0384	phenazine biosynthesis protein PhzF
L0P85_08830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L0P85_08835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L0P85_08845	COG0860	N-Acetylmuramoyl-L-alanine amidase
L0P85_08870	COG0484	heat shock protein binding
L0P85_08880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L0P85_08885	COG0443	Heat shock 70 kDa protein
L0P85_08890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L0P85_08905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L0P85_08910	COG1404	Belongs to the peptidase S8 family
L0P85_08920	COG1301	dicarboxylic acid transport
L0P85_08950	COG0531	amino acid
L0P85_08960	COG1819	glycosyl
L0P85_08975	COG0346	lactoylglutathione lyase activity
L0P85_08980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L0P85_09015	COG3404	Formiminotransferase-cyclodeaminase
L0P85_09020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L0P85_09025	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
L0P85_09035	COG0409	Hydrogenase expression formation protein
L0P85_09040	COG0309	Hydrogenase expression formation protein (HypE)
L0P85_09050	COG3546	catalase activity
L0P85_09055	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
L0P85_09080	COG0701	Predicted permease
L0P85_09085	COG0640	Transcriptional regulator
L0P85_09105	COG0798	PFAM Bile acid sodium symporter
L0P85_09250	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L0P85_09275	COG5002	protein histidine kinase activity
L0P85_09280	COG5564	TIM-barrel signal transduction protein
L0P85_09305	COG0322	excinuclease ABC activity
L0P85_09315	COG2226	methyltransferase
L0P85_09320	COG0601	transmembrane transport
L0P85_09325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L0P85_09330	COG0747	negative chemotaxis
L0P85_09335	COG0444	Belongs to the ABC transporter superfamily
L0P85_09340	COG4608	Belongs to the ABC transporter superfamily
L0P85_09360	COG1696	Membrane protein involved in D-alanine export
L0P85_09370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L0P85_09375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L0P85_09395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L0P85_09415	COG1752	Esterase of the alpha-beta hydrolase superfamily
L0P85_09420	COG0758	DNA mediated transformation
L0P85_09430	COG5577	PFAM Coat F domain
L0P85_09440	COG5002	protein histidine kinase activity
L0P85_09450	COG0534	Mate efflux family protein
L0P85_09475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L0P85_09485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L0P85_09495	COG0137	argininosuccinate synthase activity
L0P85_09500	COG0475	glutathione-regulated potassium exporter activity
L0P85_09505	COG1744	ABC transporter substrate-binding protein PnrA-like
L0P85_09535	COG3973	AAA domain
L0P85_09545	COG2081	HI0933 family
L0P85_09550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L0P85_09555	COG0204	Acyl-transferase
L0P85_09560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L0P85_09610	COG3104	oligopeptide transport
L0P85_09620	COG0582	viral genome integration into host DNA
L0P85_09630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L0P85_09655	COG2359	stage V sporulation protein S
L0P85_09660	COG4974	Belongs to the 'phage' integrase family
L0P85_09665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L0P85_09670	COG0813	purine-nucleoside phosphorylase activity
L0P85_09680	COG1216	Glycosyl transferase, family 2
L0P85_09685	COG1073	alpha beta
L0P85_09710	COG1116	anion transmembrane transporter activity
L0P85_09715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L0P85_09720	COG1079	Belongs to the binding-protein-dependent transport system permease family
L0P85_09725	COG4603	Belongs to the binding-protein-dependent transport system permease family
L0P85_09730	COG3845	ABC transporter
L0P85_09735	COG1744	ABC transporter substrate-binding protein PnrA-like
L0P85_09740	COG1316	TRANSCRIPTIONal
L0P85_09745	COG1316	TRANSCRIPTIONal
L0P85_09750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L0P85_09785	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
L0P85_09790	COG1923	regulation of RNA biosynthetic process
L0P85_09795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L0P85_09805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L0P85_09815	COG0494	nUDIX hydrolase
L0P85_09820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L0P85_09830	COG2323	membrane
L0P85_09840	COG4294	response to UV
L0P85_09855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L0P85_09865	COG1013	pyruvate-flavodoxin oxidoreductase activity
L0P85_09865	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L0P85_09865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L0P85_09865	COG0674	pyruvate-flavodoxin oxidoreductase activity
L0P85_09875	COG0446	pyridine nucleotide-disulphide oxidoreductase
L0P85_09885	COG1120	ATPase activity
L0P85_09890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_09905	COG1028	Short-chain dehydrogenase reductase Sdr
L0P85_09920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L0P85_09925	COG0473	3-isopropylmalate dehydrogenase activity
L0P85_09930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L0P85_09935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L0P85_09965	COG1737	Transcriptional regulator
L0P85_09970	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L0P85_09975	COG1187	pseudouridine synthase activity
L0P85_09985	COG0019	diaminopimelate decarboxylase activity
L0P85_10010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L0P85_10020	COG1597	lipid kinase activity
L0P85_10070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L0P85_10080	COG4948	Mandelate Racemase Muconate Lactonizing
L0P85_10095	COG1278	Cold shock
L0P85_10105	COG1378	Sugar-specific transcriptional regulator TrmB
L0P85_10130	COG0488	(ABC) transporter
L0P85_10140	COG4708	membrane
L0P85_10145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L0P85_10160	COG0024	Methionine aminopeptidase
L0P85_10165	COG0826	peptidase U32
L0P85_10170	COG0534	Mate efflux family protein
L0P85_10180	COG2252	PERMEase
L0P85_10200	COG5002	protein histidine kinase activity
L0P85_10220	COG1217	gtp-binding protein TYPA
L0P85_10260	COG0658	competence protein
L0P85_10260	COG2333	competence protein COMEC
L0P85_10265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L0P85_10280	COG1309	transcriptional regulator
L0P85_10285	COG0352	thiamine-phosphate diphosphorylase activity
L0P85_10295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L0P85_10300	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
L0P85_10305	COG0351	phosphomethylpyrimidine kinase
L0P85_10315	COG1141	Ferredoxin
L0P85_10325	COG0494	nUDIX hydrolase
L0P85_10330	COG1122	ATPase activity
L0P85_10355	COG0514	ATP-dependent DNA helicase (RecQ)
L0P85_10385	COG0492	ferredoxin-NADP+ reductase activity
L0P85_10390	COG3118	belongs to the thioredoxin family
L0P85_10395	COG5002	protein histidine kinase activity
L0P85_10415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L0P85_10420	COG1121	(ABC) transporter
L0P85_10425	COG0803	Belongs to the bacterial solute-binding protein 9 family
L0P85_10425	COG3443	Belongs to the bacterial solute-binding protein 9 family
L0P85_10435	COG0215	cysteine-tRNA ligase activity
L0P85_10450	COG1132	(ABC) transporter
L0P85_10455	COG4988	ABC transporter
L0P85_10460	COG2832	Protein of unknown function (DUF454)
L0P85_10470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_10515	COG0488	(ABC) transporter
L0P85_10550	COG1131	(ABC) transporter
L0P85_10560	COG2376	Dihydroxyacetone kinase
L0P85_10570	COG2207	Transcriptional regulator
L0P85_10595	COG0786	glutamate:sodium symporter activity
L0P85_10615	COG1283	sodium-dependent phosphate transmembrane transporter activity
L0P85_10640	COG0393	Putative heavy-metal-binding
L0P85_10645	COG0733	neurotransmitter:sodium symporter activity
L0P85_10650	COG0697	spore germination
L0P85_10660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L0P85_10675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L0P85_10675	COG0140	phosphoribosyl-ATP diphosphatase activity
L0P85_10680	COG0107	imidazoleglycerol-phosphate synthase activity
L0P85_10685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L0P85_10690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L0P85_10695	COG0131	Imidazoleglycerol-phosphate dehydratase
L0P85_10700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L0P85_10705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L0P85_10710	COG0124	histidyl-tRNA synthetase
L0P85_10725	COG0445	tRNA wobble uridine modification
L0P85_10740	COG1592	Rubrerythrin
L0P85_10740	COG1773	rubredoxin
L0P85_10745	COG2720	vancomycin resistance protein
L0P85_10760	COG0515	serine threonine protein kinase
L0P85_10760	COG2815	serine threonine protein kinase
L0P85_10770	COG3314	Sporulation integral membrane protein YlbJ
L0P85_10775	COG3457	Alanine racemase
L0P85_10820	COG0728	peptidoglycan biosynthetic process
L0P85_10870	COG0006	proline dipeptidase activity
L0P85_10920	COG0628	permease
L0P85_10935	COG2153	protein acetylation
L0P85_10950	COG2205	protein histidine kinase activity
L0P85_10980	COG2801	Transposase and inactivated derivatives
L0P85_11000	COG3620	sequence-specific DNA binding
L0P85_11025	COG1012	belongs to the aldehyde dehydrogenase family
L0P85_11135	COG1484	DNA-dependent DNA replication
L0P85_11155	COG2897	thiosulfate sulfurtransferase activity
L0P85_11170	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L0P85_11180	COG0673	inositol 2-dehydrogenase activity
L0P85_11200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L0P85_11255	COG3584	3D domain protein
L0P85_11255	COG1388	LysM domain
L0P85_11260	COG1278	Cold shock
L0P85_11285	COG1132	(ABC) transporter
L0P85_11290	COG1132	(ABC) transporter
L0P85_11305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L0P85_11320	COG1309	transcriptional regulator
L0P85_11325	COG0488	(ABC) transporter
L0P85_11380	COG0840	transmembrane signaling receptor activity
L0P85_11400	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L0P85_11400	COG1605	Chorismate mutase
L0P85_11405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L0P85_11420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L0P85_11425	COG0512	Glutamine amidotransferase of anthranilate synthase
L0P85_11440	COG1131	(ABC) transporter
L0P85_11450	COG2197	response regulator
L0P85_11455	COG3104	oligopeptide transport
L0P85_11460	COG1131	(ABC) transporter
L0P85_11500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L0P85_11520	COG0242	peptide deformylase activity
L0P85_11535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L0P85_11550	COG1131	(ABC) transporter
L0P85_11555	COG1725	Transcriptional regulator
L0P85_11560	COG2195	Cleaves the N-terminal amino acid of tripeptides
L0P85_11565	COG1288	antiporter activity
L0P85_11615	COG1511	domain protein
L0P85_11630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L0P85_11635	COG5012	cobalamin binding
L0P85_11660	COG0577	efflux transmembrane transporter activity
L0P85_11665	COG1136	(ABC) transporter
L0P85_11675	COG0745	RESPONSE REGULATOR receiver
L0P85_11695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L0P85_11710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L0P85_11725	COG1605	Chorismate mutase
L0P85_11725	COG0077	Prephenate dehydratase
L0P85_11730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L0P85_11735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L0P85_11740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L0P85_11745	COG1592	Rubrerythrin
L0P85_11745	COG1773	rubredoxin
L0P85_11755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L0P85_11765	COG1428	Deoxynucleoside kinase
L0P85_11775	COG2199	diguanylate cyclase activity
L0P85_11790	COG1737	Transcriptional regulator
L0P85_11795	COG2190	(PTS) system
L0P85_11795	COG1263	PTS System
L0P85_11795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L0P85_11810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L0P85_11810	COG1263	PTS System
L0P85_11815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L0P85_11835	COG0488	(ABC) transporter
L0P85_11855	COG1214	PFAM Peptidase M22, glycoprotease
L0P85_11855	COG0456	acetyltransferase
L0P85_11875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L0P85_11940	COG3595	metallopeptidase activity
L0P85_11990	COG0515	serine threonine protein kinase
L0P85_12015	COG3708	Transcriptional regulator
L0P85_12015	COG2207	Transcriptional regulator
L0P85_12025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L0P85_12030	COG0154	amidase activity
L0P85_12040	COG1253	flavin adenine dinucleotide binding
L0P85_12045	COG1253	flavin adenine dinucleotide binding
L0P85_12055	COG0662	Cupin 2, conserved barrel domain protein
L0P85_12105	COG0840	transmembrane signaling receptor activity
L0P85_12105	COG3290	protein histidine kinase activity
L0P85_12115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L0P85_12130	COG0488	(ABC) transporter
L0P85_12135	COG0584	glycerophosphoryl diester phosphodiesterase
L0P85_12160	COG1619	proteins homologs of microcin C7 resistance protein MccF
L0P85_12180	COG0471	metal ion transport
L0P85_12180	COG3273	potassium ion transport
L0P85_12190	COG1278	Cold shock
L0P85_12195	COG3326	Membrane
L0P85_12210	COG2032	superoxide dismutase activity
L0P85_12220	COG2340	Cysteine-rich secretory protein family
L0P85_12250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L0P85_12285	COG1278	Cold shock
L0P85_12340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L0P85_12350	COG0739	heme binding
L0P85_12365	COG0708	Exodeoxyribonuclease III
L0P85_12375	COG0436	Aminotransferase
L0P85_12390	COG0582	viral genome integration into host DNA
L0P85_12400	COG1418	mRNA catabolic process
L0P85_12405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L0P85_12410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L0P85_12415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L0P85_12420	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
L0P85_12430	COG0740	serine-type endopeptidase activity
L0P85_12435	COG0527	aspartate kinase activity
L0P85_12440	COG1873	PFAM PRC-barrel domain
L0P85_12445	COG0612	Peptidase, M16
L0P85_12455	COG1185	polyribonucleotide nucleotidyltransferase activity
L0P85_12460	COG1307	EDD domain protein, DegV family
L0P85_12465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L0P85_12470	COG0196	riboflavin kinase activity
L0P85_12475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L0P85_12480	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L0P85_12490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L0P85_12500	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L0P85_12505	COG0195	Participates in both transcription termination and antitermination
L0P85_12510	COG0779	Required for maturation of 30S ribosomal subunits
L0P85_12540	COG3874	Sporulation protein YtfJ
L0P85_12555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L0P85_12560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L0P85_12565	COG1994	Peptidase M50
L0P85_12570	COG1686	Belongs to the peptidase S11 family
L0P85_12575	COG1550	Protein conserved in bacteria
L0P85_12580	COG3679	Belongs to the UPF0342 family
L0P85_12585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L0P85_12590	COG0735	belongs to the Fur family
L0P85_12595	COG1316	TRANSCRIPTIONal
L0P85_12600	COG3906	Belongs to the UPF0473 family
L0P85_12605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L0P85_12620	COG4472	Bacterial protein of unknown function (DUF965)
L0P85_12625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L0P85_12630	COG0482	sulfurtransferase activity
L0P85_12635	COG0822	iron-sulfur transferase activity
L0P85_12645	COG1959	2 iron, 2 sulfur cluster binding
L0P85_12660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L0P85_12670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L0P85_12675	COG0758	DNA mediated transformation
L0P85_12680	COG0606	chelatase, subunit chli
L0P85_12685	COG0792	nuclease activity
L0P85_12690	COG2843	Capsule synthesis protein
L0P85_12700	COG2843	Capsule synthesis protein
L0P85_12710	COG0577	efflux transmembrane transporter activity
L0P85_12710	COG1136	(ABC) transporter
L0P85_12715	COG1136	(ABC) transporter
L0P85_12715	COG0577	efflux transmembrane transporter activity
L0P85_12720	COG5002	protein histidine kinase activity
L0P85_12720	COG3850	Histidine kinase
L0P85_12730	COG0745	RESPONSE REGULATOR receiver
L0P85_12735	COG2239	Acts as a magnesium transporter
L0P85_12745	COG0768	penicillin binding
L0P85_12750	COG1078	dGTPase activity
L0P85_12765	COG1131	(ABC) transporter
L0P85_12780	COG1442	glycosyl transferase family 8
L0P85_12780	COG1216	Glycosyl transferase, family 2
L0P85_12785	COG1136	(ABC) transporter
L0P85_12800	COG0745	RESPONSE REGULATOR receiver
L0P85_12815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L0P85_12830	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L0P85_12830	COG0392	lysyltransferase activity
L0P85_12835	COG0513	Belongs to the DEAD box helicase family
L0P85_12845	COG1114	Component of the transport system for branched-chain amino acids
L0P85_12850	COG0693	protein deglycase activity
L0P85_12870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L0P85_12875	COG1757	Na H antiporter
L0P85_12890	COG0335	large ribosomal subunit rRNA binding
L0P85_12895	COG0336	Belongs to the RNA methyltransferase TrmD family
L0P85_12900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L0P85_12910	COG0228	four-way junction DNA binding
L0P85_12915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L0P85_12920	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
L0P85_12925	COG0552	protein localization to endoplasmic reticulum
L0P85_12930	COG1196	nuclear chromosome segregation
L0P85_12935	COG1196	nuclear chromosome segregation
L0P85_12950	COG0571	ribonuclease III activity
L0P85_12960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L0P85_12990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L0P85_12995	COG5002	protein histidine kinase activity
L0P85_13010	COG2205	protein histidine kinase activity
L0P85_13025	COG1846	Transcriptional regulator
L0P85_13030	COG0826	peptidase U32
L0P85_13035	COG4122	O-methyltransferase activity
L0P85_13040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L0P85_13055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
L0P85_13060	COG4974	Belongs to the 'phage' integrase family
L0P85_13085	COG1215	transferase activity, transferring glycosyl groups
L0P85_13125	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L0P85_13130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L0P85_13135	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
L0P85_13140	COG0142	geranyltranstransferase activity
L0P85_13145	COG1722	exodeoxyribonuclease VII activity
L0P85_13150	COG1570	exodeoxyribonuclease VII activity
L0P85_13155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L0P85_13160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L0P85_13165	COG1302	Protein conserved in bacteria
L0P85_13210	COG3854	ATPases associated with a variety of cellular activities
L0P85_13220	COG3022	response to hydroperoxide
L0P85_13225	COG0416	fatty acid biosynthetic process
L0P85_13230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L0P85_13240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L0P85_13245	COG1323	Belongs to the UPF0348 family
L0P85_13250	COG3314	Sporulation integral membrane protein YlbJ
L0P85_13260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L0P85_13265	COG0742	ribosomal rna small subunit methyltransferase
L0P85_13270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L0P85_13275	COG1461	Dihydroxyacetone kinase
L0P85_13285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L0P85_13295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L0P85_13300	COG1162	GTPase activity
L0P85_13315	COG0631	protein serine/threonine phosphatase activity
L0P85_13320	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L0P85_13325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L0P85_13325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L0P85_13330	COG2738	Putative neutral zinc metallopeptidase
L0P85_13340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L0P85_13345	COG0242	peptide deformylase activity
L0P85_13355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L0P85_13360	COG1758	RNA polymerase activity
L0P85_13365	COG0194	GDP metabolic process
L0P85_13370	COG1561	YicC-like family, N-terminal region
L0P85_13375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L0P85_13385	COG1293	RNA-binding protein homologous to eukaryotic snRNP
L0P85_13400	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L0P85_13405	COG0564	pseudouridine synthase activity
L0P85_13410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L0P85_13420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L0P85_13430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L0P85_13445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L0P85_13450	COG3599	regulation of cell shape
L0P85_13465	COG1799	cell septum assembly
L0P85_13470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L0P85_13490	COG1115	amino acid carrier protein
L0P85_13495	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L0P85_13500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L0P85_13505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L0P85_13510	COG1160	GTP binding
L0P85_13535	COG5002	protein histidine kinase activity
L0P85_13540	COG0745	RESPONSE REGULATOR receiver
L0P85_13550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L0P85_13555	COG1873	PFAM PRC-barrel domain
L0P85_13560	COG1191	sigma factor activity
L0P85_13565	COG1191	sigma factor activity
L0P85_13575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L0P85_13585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L0P85_13595	COG0772	Belongs to the SEDS family
L0P85_13600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L0P85_13605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L0P85_13610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L0P85_13615	COG0768	penicillin binding
L0P85_13630	COG0534	Mate efflux family protein
L0P85_13635	COG2873	o-acetylhomoserine
L0P85_13640	COG0275	rRNA processing
L0P85_13645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L0P85_13650	COG4464	protein tyrosine phosphatase activity
L0P85_13655	COG0612	Peptidase, M16
L0P85_13660	COG0612	Peptidase, M16
L0P85_13665	COG0012	GTP binding
L0P85_13680	COG0515	serine threonine protein kinase
L0P85_13680	COG2815	serine threonine protein kinase
L0P85_13695	COG1914	H( )-stimulated, divalent metal cation uptake system
L0P85_13705	COG4336	lyase activity
L0P85_13710	COG0439	Biotin carboxylase
L0P85_13720	COG1984	allophanate hydrolase subunit 2
L0P85_13725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L0P85_13740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L0P85_13745	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
L0P85_13780	COG3706	GGDEF domain
L0P85_13795	COG1012	belongs to the aldehyde dehydrogenase family
L0P85_13795	COG1454	alcohol dehydrogenase
L0P85_13810	COG0617	tRNA 3'-terminal CCA addition
L0P85_13820	COG1454	alcohol dehydrogenase
L0P85_13820	COG1012	belongs to the aldehyde dehydrogenase family
L0P85_13825	COG0561	phosphatase activity
L0P85_13845	COG1126	abc transporter atp-binding protein
L0P85_13850	COG0765	amino acid transport
L0P85_13855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L0P85_13860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L0P85_13870	COG0534	Mate efflux family protein
L0P85_13880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L0P85_13890	COG0398	Pfam SNARE associated Golgi protein
L0P85_13895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L0P85_13905	COG1301	dicarboxylic acid transport
L0P85_13925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L0P85_13930	COG1869	D-ribose catabolic process
L0P85_13935	COG1129	ABC transporter
L0P85_13940	COG1172	Belongs to the binding-protein-dependent transport system permease family
L0P85_13945	COG1879	ABC-type sugar transport system periplasmic component
L0P85_13970	COG1193	negative regulation of DNA recombination
L0P85_13975	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L0P85_13980	COG4149	molybdate abc transporter
L0P85_13985	COG0725	ABC transporter, periplasmic molybdate-binding protein
L0P85_13990	COG1910	domain protein
L0P85_14035	COG2197	response regulator
L0P85_14040	COG0561	phosphatase activity
L0P85_14060	COG1528	Iron-storage protein
L0P85_14070	COG2409	Drug exporters of the RND superfamily
L0P85_14080	COG1418	mRNA catabolic process
L0P85_14100	COG2801	Transposase and inactivated derivatives
L0P85_14105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L0P85_14125	COG1136	(ABC) transporter
L0P85_14185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L0P85_14190	COG0753	catalase activity
L0P85_14200	COG0310	cobalt ion transport
L0P85_14235	COG0573	inorganic phosphate transmembrane transporter activity
L0P85_14240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L0P85_14245	COG1396	sequence-specific DNA binding
L0P85_14250	COG1773	rubredoxin
L0P85_14250	COG1592	Rubrerythrin
L0P85_14280	COG2217	Heavy metal translocating P-type atpase
L0P85_14285	COG5002	protein histidine kinase activity
L0P85_14295	COG0785	Cytochrome C biogenesis protein
L0P85_14330	COG4509	Sortase family
L0P85_14350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0P85_14370	COG0791	NLP P60 protein
L0P85_14375	COG0791	NLP P60 protein
L0P85_14375	COG1388	LysM domain
L0P85_14375	COG3103	Sh3 type 3 domain protein
L0P85_14380	COG0756	dUTP diphosphatase activity
L0P85_14385	COG0551	DNA topoisomerase type I activity
L0P85_14385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L0P85_14390	COG2195	Cleaves the N-terminal amino acid of tripeptides
L0P85_14400	COG0006	proline dipeptidase activity
L0P85_14415	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L0P85_14425	COG2205	protein histidine kinase activity
L0P85_14430	COG0745	RESPONSE REGULATOR receiver
L0P85_14435	COG0574	Belongs to the PEP-utilizing enzyme family
L0P85_14435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L0P85_14440	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L0P85_14445	COG0517	IMP dehydrogenase activity
L0P85_14450	COG0751	glycine-tRNA ligase activity
L0P85_14455	COG0752	glycyl-tRNA synthetase alpha subunit
L0P85_14465	COG1381	Involved in DNA repair and RecF pathway recombination
L0P85_14470	COG2239	Acts as a magnesium transporter
L0P85_14475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L0P85_14480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L0P85_14485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L0P85_14490	COG1702	phosphate starvation-inducible protein PhoH
L0P85_14505	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
L0P85_14510	COG1610	YqeY-like protein
L0P85_14515	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L0P85_14520	COG0537	adenosine 5'-monophosphoramidase activity
L0P85_14525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L0P85_14530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L0P85_14535	COG2264	protein methyltransferase activity
L0P85_14540	COG0484	heat shock protein binding
L0P85_14545	COG0443	Heat shock 70 kDa protein
L0P85_14550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L0P85_14555	COG1420	regulation of RNA biosynthetic process
L0P85_14560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L0P85_14580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L0P85_14585	COG0481	GTPase activity
L0P85_14605	COG0268	Binds directly to 16S ribosomal RNA
L0P85_14610	COG1466	dna polymerase III delta subunit
L0P85_14615	COG0658	competence protein
L0P85_14615	COG2333	competence protein COMEC
L0P85_14635	COG0658	competence protein
L0P85_14635	COG2333	competence protein COMEC
L0P85_14640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L0P85_14645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L0P85_14655	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L0P85_14660	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L0P85_14665	COG1982	Orn Lys Arg decarboxylase major
L0P85_14680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L0P85_14695	COG1596	polysaccharide export
L0P85_14695	COG1555	photosystem II stabilization
L0P85_14700	COG1686	Belongs to the peptidase S11 family
L0P85_14705	COG0165	Argininosuccinate lyase
L0P85_14710	COG0561	phosphatase activity
L0P85_14720	COG0251	oxidation-reduction process
L0P85_14725	COG0495	leucyl-tRNA aminoacylation
L0P85_14730	COG0799	negative regulation of ribosome biogenesis
L0P85_14735	COG1713	HD superfamily hydrolase involved in NAD metabolism
L0P85_14740	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L0P85_14745	COG2137	regulation of response to DNA damage stimulus
L0P85_14750	COG1234	tRNA 3'-trailer cleavage
L0P85_14760	COG3655	Transcriptional regulator
L0P85_14780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L0P85_14785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L0P85_14795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L0P85_14815	COG0426	domain, Protein
L0P85_14820	COG1803	Methylglyoxal synthase
L0P85_14825	COG0772	Belongs to the SEDS family
L0P85_14830	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L0P85_14835	COG2894	cell division
L0P85_14840	COG0850	regulation of cytokinetic process
L0P85_14845	COG0768	penicillin binding
L0P85_14860	COG1077	Cell shape determining protein MreB Mrl
L0P85_14865	COG2003	Belongs to the UPF0758 family
L0P85_14870	COG0424	maF-like protein
L0P85_14875	COG2878	Part of a membrane complex involved in electron transport
L0P85_14875	COG1245	4Fe-4S binding domain
L0P85_14880	COG4657	Part of a membrane complex involved in electron transport
L0P85_14885	COG4660	Part of a membrane complex involved in electron transport
L0P85_14890	COG4659	FMN binding
L0P85_14895	COG4658	electron transport chain
L0P85_14900	COG4656	Part of a membrane complex involved in electron transport
L0P85_14910	COG3103	Sh3 type 3 domain protein
L0P85_14910	COG1388	LysM domain
L0P85_14910	COG0791	NLP P60 protein
L0P85_14915	COG0346	lactoylglutathione lyase activity
L0P85_14935	COG4377	Putative membrane peptidase family (DUF2324)
L0P85_14945	COG3279	Response regulator of the LytR AlgR family
L0P85_14955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L0P85_14975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L0P85_14975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L0P85_14995	COG0840	transmembrane signaling receptor activity
L0P85_15000	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
L0P85_15005	COG2267	carboxylic ester hydrolase activity
L0P85_15020	COG1362	aminopeptidase activity
L0P85_15025	COG4224	UPF0291 protein
L0P85_15030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L0P85_15035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L0P85_15040	COG2244	polysaccharide biosynthetic process
L0P85_15075	COG1268	BioY protein
L0P85_15090	COG1228	amidohydrolase
L0P85_15100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L0P85_15110	COG2801	Transposase and inactivated derivatives
L0P85_15130	COG1695	Transcriptional regulator
L0P85_15140	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
L0P85_15150	COG0789	Transcriptional regulator
L0P85_15160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L0P85_15165	COG1070	Carbohydrate kinase
L0P85_15170	COG2115	Belongs to the xylose isomerase family
L0P85_15175	COG1940	carbohydrate kinase activity
L0P85_15180	COG1172	Belongs to the binding-protein-dependent transport system permease family
L0P85_15190	COG4213	ABC transporter substrate-binding protein
L0P85_15205	COG0039	L-malate dehydrogenase activity
L0P85_15235	COG1595	DNA-templated transcription, initiation
L0P85_15240	COG0537	adenosine 5'-monophosphoramidase activity
L0P85_15270	COG3842	ATPase activity
L0P85_15275	COG4149	molybdate abc transporter
L0P85_15285	COG0494	nUDIX hydrolase
L0P85_15295	COG2086	electron transfer activity
L0P85_15300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L0P85_15310	COG1846	Transcriptional regulator
L0P85_15355	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L0P85_15365	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L0P85_15375	COG3013	Belongs to the UPF0304 family
L0P85_15405	COG0288	reversible hydration of carbon dioxide
L0P85_15420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L0P85_15450	COG1120	ATPase activity
L0P85_15455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_15460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L0P85_15465	COG0405	Gamma-glutamyltransferase
L0P85_15470	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L0P85_15475	COG2030	dehydratase
L0P85_15480	COG2223	nitrite transmembrane transporter activity
L0P85_15490	COG0183	Belongs to the thiolase family
L0P85_15495	COG1028	Short-chain dehydrogenase reductase Sdr
L0P85_15500	COG0583	DNA-binding transcription factor activity
L0P85_15510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L0P85_15515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L0P85_15520	COG1116	anion transmembrane transporter activity
L0P85_15530	COG4608	Belongs to the ABC transporter superfamily
L0P85_15535	COG0444	Belongs to the ABC transporter superfamily
L0P85_15540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L0P85_15545	COG0601	transmembrane transport
L0P85_15560	COG1136	(ABC) transporter
L0P85_15565	COG2205	protein histidine kinase activity
L0P85_15570	COG0745	RESPONSE REGULATOR receiver
L0P85_15575	COG3547	Transposase (IS116 IS110 IS902 family)
L0P85_15580	COG3584	3D domain protein
L0P85_15580	COG1388	LysM domain
L0P85_15590	COG0577	efflux transmembrane transporter activity
L0P85_15595	COG1136	(ABC) transporter
L0P85_15630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L0P85_15655	COG1215	transferase activity, transferring glycosyl groups
L0P85_15665	COG2089	acid synthase
L0P85_15680	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
L0P85_15690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L0P85_15695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L0P85_15700	COG0110	maltose O-acetyltransferase activity
L0P85_15705	COG1086	Polysaccharide biosynthesis protein
L0P85_15765	COG1120	ATPase activity
L0P85_15770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_15775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L0P85_15780	COG1120	ATPase activity
L0P85_15785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_15790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L0P85_15800	COG0564	pseudouridine synthase activity
L0P85_15805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L0P85_15810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L0P85_15815	COG0622	Phosphoesterase
L0P85_15825	COG1253	flavin adenine dinucleotide binding
L0P85_15830	COG0419	ATPase involved in DNA repair
L0P85_15840	COG0419	ATPase involved in DNA repair
L0P85_15845	COG0420	3'-5' exonuclease activity
L0P85_15850	COG1074	ATP-dependent DNA helicase activity
L0P85_15855	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
L0P85_15865	COG0210	DNA helicase
L0P85_15880	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
L0P85_15905	COG1609	Transcriptional regulator
L0P85_15930	COG1924	4 iron, 4 sulfur cluster binding
L0P85_15935	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
L0P85_15960	COG3069	C4-dicarboxylate transmembrane transporter activity
L0P85_15980	COG1230	cation diffusion facilitator family transporter
L0P85_15985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L0P85_15990	COG4868	Belongs to the UPF0371 family
L0P85_16000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L0P85_16010	COG1473	amidohydrolase
L0P85_16020	COG0534	Mate efflux family protein
L0P85_16050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L0P85_16055	COG2195	Cleaves the N-terminal amino acid of tripeptides
L0P85_16115	COG0531	amino acid
L0P85_16125	COG0280	phosphate acetyltransferase
L0P85_16130	COG0789	Transcriptional regulator
L0P85_16130	COG4978	Transcriptional regulator
L0P85_16135	COG3426	butyrate kinase activity
L0P85_16170	COG5002	protein histidine kinase activity
L0P85_16175	COG0629	single-stranded DNA binding
L0P85_16185	COG0058	SHG alpha-glucan phosphorylase activity
L0P85_16190	COG0297	glycogen (starch) synthase activity
L0P85_16195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L0P85_16200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L0P85_16205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L0P85_16220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L0P85_16220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L0P85_16230	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L0P85_16245	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L0P85_16275	COG1671	Belongs to the UPF0178 family
L0P85_16280	COG2133	pyrroloquinoline quinone binding
L0P85_16280	COG5183	chlorophyll binding
L0P85_16285	COG1191	sigma factor activity
L0P85_16290	COG0656	L-ascorbic acid biosynthetic process
L0P85_16315	COG0446	pyridine nucleotide-disulphide oxidoreductase
L0P85_16325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L0P85_16345	COG4260	virion core protein, lumpy skin disease virus
L0P85_16355	COG1842	Phage shock protein A
L0P85_16360	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L0P85_16375	COG2199	diguanylate cyclase activity
L0P85_16375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L0P85_16410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L0P85_16430	COG0602	queuosine metabolic process
L0P85_16445	COG1328	CTP reductase activity
L0P85_16475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
L0P85_16480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L0P85_16485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L0P85_16490	COG0124	histidyl-tRNA synthetase
L0P85_16495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L0P85_16500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L0P85_16505	COG1490	D-aminoacyl-tRNA deacylase activity
L0P85_16510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L0P85_16515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L0P85_16525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L0P85_16525	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L0P85_16550	COG1862	Preprotein translocase
L0P85_16555	COG0343	queuine tRNA-ribosyltransferase activity
L0P85_16565	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L0P85_16570	COG2255	four-way junction helicase activity
L0P85_16575	COG0632	four-way junction helicase activity
L0P85_16580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L0P85_16620	COG0789	Transcriptional regulator
L0P85_16625	COG0217	transcriptional regulatory protein
L0P85_16630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L0P85_16635	COG0730	response to heat
L0P85_16650	COG1739	Uncharacterized protein family UPF0029
L0P85_16665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L0P85_16680	COG0488	(ABC) transporter
L0P85_16690	COG0860	N-Acetylmuramoyl-L-alanine amidase
L0P85_16700	COG0750	zinc metalloprotease
L0P85_16715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L0P85_16725	COG1191	sigma factor activity
L0P85_16740	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L0P85_16750	COG0530	calcium, potassium:sodium antiporter activity
L0P85_16760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L0P85_16765	COG0301	tRNA thio-modification
L0P85_16770	COG1104	cysteine desulfurase activity
L0P85_16780	COG1126	abc transporter atp-binding protein
L0P85_16785	COG0765	amino acid transport
L0P85_16790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L0P85_16795	COG0210	DNA helicase
L0P85_16840	COG1120	ATPase activity
L0P85_16845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0P85_16860	COG0509	glycine decarboxylation via glycine cleavage system
L0P85_16870	COG1410	methionine synthase
L0P85_16870	COG0646	methionine synthase
L0P85_16890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L0P85_16895	COG0646	methionine synthase
L0P85_16895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L0P85_16905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L0P85_16910	COG3404	Formiminotransferase-cyclodeaminase
L0P85_16915	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L0P85_16925	COG1151	hydroxylamine reductase activity
L0P85_16950	COG0018	arginyl-trna synthetase
L0P85_16955	COG1683	Conserved Protein
L0P85_16960	COG1193	negative regulation of DNA recombination
L0P85_16965	COG2195	Cleaves the N-terminal amino acid of tripeptides
L0P85_16970	COG0826	peptidase U32
L0P85_16980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L0P85_16980	COG0072	phenylalanine-tRNA ligase activity
L0P85_16985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L0P85_16990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L0P85_16995	COG0569	domain protein
L0P85_17000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L0P85_17005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L0P85_17010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L0P85_17015	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L0P85_17035	COG1079	Belongs to the binding-protein-dependent transport system permease family
L0P85_17040	COG4603	Belongs to the binding-protein-dependent transport system permease family
L0P85_17045	COG3845	ABC transporter
L0P85_17050	COG1744	ABC transporter substrate-binding protein PnrA-like
L0P85_17055	COG1307	EDD domain protein, DegV family
L0P85_17060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L0P85_17065	COG2720	vancomycin resistance protein
L0P85_17070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L0P85_17075	COG1067	ATP-dependent peptidase activity
L0P85_17080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L0P85_17090	COG2066	Belongs to the glutaminase family
L0P85_17095	COG0667	Aldo Keto reductase
L0P85_17105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L0P85_17115	COG2339	peptidase activity
L0P85_17155	COG0561	phosphatase activity
L0P85_17160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L0P85_17175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L0P85_17195	COG2267	carboxylic ester hydrolase activity
L0P85_17205	COG1187	pseudouridine synthase activity
L0P85_17235	COG0322	excinuclease ABC activity
L0P85_17245	COG0556	nucleotide-excision repair
L0P85_17305	COG2217	Heavy metal translocating P-type atpase
L0P85_17360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L0P85_17365	COG1309	transcriptional regulator
L0P85_17375	COG0071	Belongs to the small heat shock protein (HSP20) family
L0P85_17380	COG5275	peptidyl-tyrosine sulfation
L0P85_17380	COG0252	asparaginase activity
L0P85_17385	COG5275	peptidyl-tyrosine sulfation
L0P85_17385	COG0252	asparaginase activity
L0P85_17390	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
L0P85_17400	COG5275	peptidyl-tyrosine sulfation
L0P85_17400	COG0252	asparaginase activity
L0P85_17405	COG4656	Part of a membrane complex involved in electron transport
L0P85_17420	COG1131	(ABC) transporter
L0P85_17430	COG1595	DNA-templated transcription, initiation
L0P85_17450	COG0151	Belongs to the GarS family
L0P85_17455	COG0138	bifunctional purine biosynthesis protein purh
L0P85_17460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L0P85_17465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L0P85_17475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L0P85_17480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L0P85_17495	COG1744	ABC transporter substrate-binding protein PnrA-like
L0P85_17500	COG0519	Catalyzes the synthesis of GMP from XMP
L0P85_17500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L0P85_17505	COG0517	IMP dehydrogenase activity
L0P85_17505	COG0516	GMP reductase activity
L0P85_17510	COG1691	(AIR) carboxylase
L0P85_17515	COG0459	protein refolding
L0P85_17520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L0P85_17535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L0P85_17545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L0P85_17550	COG0167	dihydroorotate dehydrogenase activity
L0P85_17555	COG0543	2 iron, 2 sulfur cluster binding
L0P85_17560	COG0540	Belongs to the ATCase OTCase family
L0P85_17580	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L0P85_17585	COG0488	(ABC) transporter
L0P85_17590	COG0251	oxidation-reduction process
L0P85_17595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L0P85_17600	COG0456	acetyltransferase
L0P85_17605	COG1214	PFAM Peptidase M22, glycoprotease
L0P85_17610	COG0802	atpase or kinase
L0P85_17615	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L0P85_17620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L0P85_17625	COG2183	response to ionizing radiation
L0P85_17635	COG0653	protein targeting
L0P85_17645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L0P85_17650	COG1040	competence protein
L0P85_17655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L0P85_17660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L0P85_17670	COG1077	Cell shape determining protein MreB Mrl
L0P85_17675	COG1609	Transcriptional regulator
L0P85_17685	COG2385	sporulation resulting in formation of a cellular spore
L0P85_17690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L0P85_17705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L0P85_17740	COG0280	phosphate acetyltransferase
L0P85_17750	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L0P85_17920	COG0602	queuosine metabolic process
L0P85_17955	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L0P85_17960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L0P85_17970	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L0P85_17985	COG3191	aminopeptidase activity
L0P85_17995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L0P85_18000	COG0037	tRNA processing
L0P85_18010	COG3773	Cell wall hydrolase
L0P85_18010	COG3409	Peptidoglycan-binding domain 1 protein
L0P85_18020	COG1802	Transcriptional regulator
L0P85_18025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L0P85_18035	COG4466	Protein conserved in bacteria
L0P85_18055	COG0653	protein targeting
L0P85_18065	COG0564	pseudouridine synthase activity
L0P85_18090	COG0284	orotidine-5'-phosphate decarboxylase activity
L0P85_18105	COG0646	methionine synthase
L0P85_18105	COG1410	methionine synthase
L0P85_18115	COG1854	S-ribosylhomocysteine lyase activity
L0P85_18130	COG0579	oxidoreductase
L0P85_18140	COG2824	Alkylphosphonate utilization operon protein PhnA
L0P85_18150	COG3958	Transketolase
L0P85_18155	COG3959	Transketolase, thiamine diphosphate binding domain
L0P85_18175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0P85_18175	COG3711	transcriptional antiterminator
L0P85_18200	COG0390	transport system, permease component
L0P85_18205	COG4619	ABC transporter
L0P85_18210	COG0037	tRNA processing
L0P85_18230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L0P85_18235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L0P85_18255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L0P85_18265	COG0305	Participates in initiation and elongation during chromosome replication
L0P85_18270	COG0359	binds to the 23S rRNA
L0P85_18275	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
L0P85_18290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L0P85_18295	COG0629	single-stranded DNA binding
L0P85_18300	COG0360	Binds together with S18 to 16S ribosomal RNA
L0P85_18305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L0P85_18310	COG4481	Protein conserved in bacteria
L0P85_18320	COG1475	DNA binding
L0P85_18330	COG1475	DNA binding
L0P85_18335	COG0357	Ribosomal RNA small subunit methyltransferase G
L0P85_18340	COG0445	tRNA wobble uridine modification
L0P85_18345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L0P85_18350	COG1847	R3H domain protein
L0P85_18355	COG0706	membrane insertase activity
L0P85_18360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L0P85_18365	COG0594	ribonuclease P activity
L0P85_18370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L0P85_18375	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L0P85_18380	COG0592	DNA-directed DNA polymerase activity
L0P85_18390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L0P85_18395	COG0187	DNA topoisomerase II activity
L0P85_18400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L0P85_18420	COG2172	sigma factor antagonist activity
L0P85_18495	COG3842	ATPase activity
L0P85_18520	COG0590	tRNA wobble adenosine to inosine editing
L0P85_18535	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L0P85_18545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L0P85_18560	COG1393	Belongs to the ArsC family
L0P85_18800	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L0P85_18805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L0P85_18810	COG4463	regulation of RNA biosynthetic process
L0P85_18820	COG3869	Catalyzes the specific phosphorylation of arginine residues in
L0P85_18825	COG0542	response to heat
L0P85_18830	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L0P85_18835	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
L0P85_18840	COG4956	integral membrane protein (PIN domain superfamily)
L0P85_18845	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L0P85_18850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L0P85_18855	COG0442	prolyl-tRNA aminoacylation
L0P85_18860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L0P85_18865	COG0215	cysteine-tRNA ligase activity
L0P85_18880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L0P85_18885	COG3688	RNA-binding protein containing a PIN domain
L0P85_18895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L0P85_18900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L0P85_18910	COG0250	Participates in transcription elongation, termination and antitermination
L0P85_18915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L0P85_18920	COG0081	regulation of translation
L0P85_18925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L0P85_18930	COG0222	ribosome binding
L0P85_18935	COG0085	RNA polymerase activity
L0P85_18940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L0P85_18945	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L0P85_18950	COG0049	tRNA binding
L0P85_18960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L0P85_18965	COG0051	transcription antitermination factor activity, RNA binding
L0P85_18970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L0P85_18975	COG0088	Forms part of the polypeptide exit tunnel
L0P85_18980	COG0089	rRNA binding
L0P85_18985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L0P85_18990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L0P85_18995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L0P85_19000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L0P85_19005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L0P85_19010	COG0255	Belongs to the universal ribosomal protein uL29 family
L0P85_19015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L0P85_19020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L0P85_19025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L0P85_19030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L0P85_19035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L0P85_19040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L0P85_19045	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L0P85_19050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L0P85_19055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L0P85_19060	COG1841	ribosomal large subunit assembly
L0P85_19065	COG0200	Binds to the 23S rRNA
L0P85_19075	COG0563	adenylate kinase activity
L0P85_19085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L0P85_19090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L0P85_19095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L0P85_19100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L0P85_19105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L0P85_19110	COG0202	RNA polymerase activity
L0P85_19115	COG0203	ribosomal protein L17
L0P85_19120	COG1122	ATPase activity
L0P85_19125	COG1122	ATPase activity
L0P85_19130	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L0P85_19135	COG0101	tRNA pseudouridine synthase activity
L0P85_19140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L0P85_19145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L0P85_19150	COG1592	Rubrerythrin
L0P85_19165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L0P85_19165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L0P85_19170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L0P85_19190	COG5002	protein histidine kinase activity