locus-tag	class	description
JW646_00010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JW646_00030	COG2604	Protein of unknown function DUF115
JW646_00065	COG2234	aminopeptidase activity
JW646_00070	COG4213	ABC transporter substrate-binding protein
JW646_00075	COG1172	Belongs to the binding-protein-dependent transport system permease family
JW646_00100	COG1819	glycosyl
JW646_00105	COG3620	sequence-specific DNA binding
JW646_00115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JW646_00135	COG1690	Belongs to the RtcB family
JW646_00165	COG0693	protein deglycase activity
JW646_00190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JW646_00200	COG2249	NAD(P)H dehydrogenase (quinone) activity
JW646_00205	COG0375	protein maturation
JW646_00240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JW646_00245	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JW646_00260	COG0789	Transcriptional regulator
JW646_00260	COG4978	Transcriptional regulator
JW646_00275	COG0791	NLP P60 protein
JW646_00280	COG0784	Response regulator, receiver
JW646_00280	COG2205	protein histidine kinase activity
JW646_00285	COG1773	rubredoxin
JW646_00285	COG1592	Rubrerythrin
JW646_00290	COG1704	LemA family
JW646_00300	COG5002	protein histidine kinase activity
JW646_00305	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JW646_00310	COG2116	formate transmembrane transporter activity
JW646_00355	COG4978	Transcriptional regulator
JW646_00355	COG0789	Transcriptional regulator
JW646_00360	COG1028	Short-chain dehydrogenase reductase Sdr
JW646_00385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JW646_00390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JW646_00395	COG1151	hydroxylamine reductase activity
JW646_00430	COG1309	transcriptional regulator
JW646_00460	COG3620	sequence-specific DNA binding
JW646_00465	COG1054	Belongs to the UPF0176 family
JW646_00475	COG3655	Transcriptional regulator
JW646_00505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JW646_00515	COG1053	succinate dehydrogenase
JW646_00515	COG3976	FMN-binding domain protein
JW646_00525	COG1045	serine acetyltransferase
JW646_00530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JW646_00535	COG3829	transcription factor binding
JW646_00575	COG3708	Transcriptional regulator
JW646_00575	COG2207	Transcriptional regulator
JW646_00585	COG3123	guanosine phosphorylase activity
JW646_00590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JW646_00605	COG1396	sequence-specific DNA binding
JW646_00610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JW646_00615	COG1473	amidohydrolase
JW646_00620	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JW646_00625	COG1473	amidohydrolase
JW646_00635	COG0277	FAD linked oxidase domain protein
JW646_00640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JW646_00650	COG3875	lactate racemase activity
JW646_00655	COG1620	l-lactate permease
JW646_00660	COG2186	Transcriptional regulator
JW646_00665	COG1773	rubredoxin
JW646_00670	COG1307	EDD domain protein, DegV family
JW646_00690	COG0295	cytidine deaminase activity
JW646_00695	COG0297	glycogen (starch) synthase activity
JW646_00695	COG0438	transferase activity, transferring glycosyl groups
JW646_00705	COG5002	protein histidine kinase activity
JW646_00710	COG0745	RESPONSE REGULATOR receiver
JW646_00730	COG0116	Belongs to the methyltransferase superfamily
JW646_00735	COG1606	tRNA processing
JW646_00740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JW646_00745	COG0531	amino acid
JW646_00750	COG0531	amino acid
JW646_00760	COG1131	(ABC) transporter
JW646_00765	COG1725	Transcriptional regulator
JW646_00770	COG1393	Belongs to the ArsC family
JW646_00785	COG0534	Mate efflux family protein
JW646_00820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JW646_00835	COG0460	homoserine dehydrogenase
JW646_00840	COG1295	ribonuclease BN
JW646_00845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JW646_00850	COG1388	LysM domain
JW646_00850	COG3584	3D domain protein
JW646_00875	COG0456	acetyltransferase
JW646_00885	COG2378	regulation of single-species biofilm formation
JW646_00890	COG1454	alcohol dehydrogenase
JW646_00895	COG4977	sequence-specific DNA binding
JW646_00900	COG1509	lysine 2,3-aminomutase activity
JW646_00910	COG1757	Na H antiporter
JW646_00915	COG1757	Na H antiporter
JW646_00920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JW646_00925	COG1757	Na H antiporter
JW646_00935	COG0095	Lipoate-protein ligase
JW646_00940	COG0398	Pfam SNARE associated Golgi protein
JW646_00945	COG0668	transmembrane transport
JW646_00950	COG0019	diaminopimelate decarboxylase activity
JW646_00955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JW646_00960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JW646_00965	COG0154	amidase activity
JW646_00970	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JW646_00975	COG0017	Asparaginyl-tRNA synthetase
JW646_00980	COG1592	Rubrerythrin
JW646_00980	COG1773	rubredoxin
JW646_01015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JW646_01020	COG2384	SAM-dependent methyltransferase
JW646_01025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JW646_01030	COG0358	DNA primase activity
JW646_01040	COG2132	Multicopper oxidase
JW646_01060	COG2340	Cysteine-rich secretory protein family
JW646_01085	COG2720	vancomycin resistance protein
JW646_01105	COG0450	alkyl hydroperoxide reductase
JW646_01115	COG2207	Transcriptional regulator
JW646_01115	COG3708	Transcriptional regulator
JW646_01210	COG0629	single-stranded DNA binding
JW646_01265	COG1396	sequence-specific DNA binding
JW646_01335	COG1199	ATP-dependent helicase activity
JW646_01335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JW646_01340	COG0726	polysaccharide deacetylase
JW646_01355	COG0789	Transcriptional regulator
JW646_01355	COG4978	Transcriptional regulator
JW646_01385	COG1668	transmembrane transport
JW646_01390	COG4555	ABC transporter
JW646_01395	COG1404	Belongs to the peptidase S8 family
JW646_01400	COG3104	oligopeptide transport
JW646_01410	COG2897	thiosulfate sulfurtransferase activity
JW646_01420	COG1132	(ABC) transporter
JW646_01450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JW646_01455	COG2720	vancomycin resistance protein
JW646_01460	COG1242	4 iron, 4 sulfur cluster binding
JW646_01485	COG3829	transcription factor binding
JW646_01490	COG1357	PFAM Pentapeptide repeats (8 copies)
JW646_01495	COG0693	protein deglycase activity
JW646_01505	COG0561	phosphatase activity
JW646_01510	COG1058	Belongs to the CinA family
JW646_01510	COG1546	Belongs to the CinA family
JW646_01520	COG0789	Transcriptional regulator
JW646_01535	COG1309	transcriptional regulator
JW646_01545	COG3620	sequence-specific DNA binding
JW646_01550	COG3853	Toxic anion resistance protein (TelA)
JW646_01575	COG3300	MHYT domain
JW646_01575	COG5001	Diguanylate cyclase
JW646_01580	COG1733	regulation of RNA biosynthetic process
JW646_01585	COG0778	Nitroreductase
JW646_01615	COG0789	Transcriptional regulator
JW646_01615	COG4978	Transcriptional regulator
JW646_01625	COG1011	Hydrolase
JW646_01640	COG4895	conserved protein (DUF2196)
JW646_01675	COG1396	sequence-specific DNA binding
JW646_01730	COG0517	IMP dehydrogenase activity
JW646_01735	COG4326	sporulation control protein
JW646_01800	COG2203	Gaf domain
JW646_01800	COG2199	diguanylate cyclase activity
JW646_01870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JW646_01870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JW646_01900	COG3706	GGDEF domain
JW646_01905	COG0531	amino acid
JW646_01910	COG0038	chloride channel
JW646_01920	COG1114	Component of the transport system for branched-chain amino acids
JW646_01950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JW646_01965	COG1114	Component of the transport system for branched-chain amino acids
JW646_01985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JW646_01985	COG0167	dihydroorotate dehydrogenase activity
JW646_01990	COG0493	'glutamate synthase
JW646_02000	COG1609	Transcriptional regulator
JW646_02025	COG3153	acetyltransferase
JW646_02045	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JW646_02060	COG0235	Class ii aldolase
JW646_02065	COG1349	DNA-binding transcription factor activity
JW646_02070	COG1979	alcohol dehydrogenase
JW646_02075	COG0626	cystathionine gamma-synthase activity
JW646_02085	COG2610	gluconate transmembrane transporter activity
JW646_02090	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JW646_02095	COG3395	kinase activity
JW646_02100	COG1349	DNA-binding transcription factor activity
JW646_02105	COG1126	abc transporter atp-binding protein
JW646_02110	COG0765	amino acid transport
JW646_02140	COG1126	abc transporter atp-binding protein
JW646_02145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JW646_02150	COG0601	transmembrane transport
JW646_02165	COG0583	DNA-binding transcription factor activity
JW646_02170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JW646_02415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JW646_02420	COG0583	DNA-binding transcription factor activity
JW646_02430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JW646_02440	COG4086	secreted protein
JW646_02445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JW646_02450	COG2094	Belongs to the DNA glycosylase MPG family
JW646_02460	COG1464	Belongs to the NlpA lipoprotein family
JW646_02465	COG2011	ABC-type metal ion transport system permease component
JW646_02470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JW646_02480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JW646_02505	COG0750	zinc metalloprotease
JW646_02510	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JW646_02515	COG4589	Belongs to the CDS family
JW646_02530	COG0233	cytoplasmic translational termination
JW646_02535	COG0528	UMP kinase activity
JW646_02540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JW646_02545	COG0052	Belongs to the universal ribosomal protein uS2 family
JW646_02550	COG1686	Belongs to the peptidase S11 family
JW646_02580	COG1115	amino acid carrier protein
JW646_02590	COG0628	permease
JW646_02600	COG2720	vancomycin resistance protein
JW646_02625	COG3584	3D domain protein
JW646_02625	COG1388	LysM domain
JW646_02630	COG3584	3D domain protein
JW646_02630	COG1388	LysM domain
JW646_02640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW646_02640	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW646_02645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JW646_02660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JW646_02665	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
JW646_02705	COG4667	esterase of the alpha-beta hydrolase superfamily
JW646_02710	COG1404	Belongs to the peptidase S8 family
JW646_02710	COG1404	Belongs to the peptidase S8 family
JW646_02715	COG1404	Belongs to the peptidase S8 family
JW646_02725	COG1404	Belongs to the peptidase S8 family
JW646_02740	COG1404	Belongs to the peptidase S8 family
JW646_02770	COG0662	Cupin 2, conserved barrel domain protein
JW646_02775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JW646_02780	COG0723	plastoquinol--plastocyanin reductase activity
JW646_02780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JW646_02785	COG2188	Transcriptional regulator
JW646_02790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JW646_02800	COG1447	Phosphotransferase system cellobiose-specific component IIA
JW646_02805	COG3394	polysaccharide catabolic process
JW646_02810	COG1486	melibiose metabolic process
JW646_02815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JW646_02820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JW646_02825	COG2188	Transcriptional regulator
JW646_02830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JW646_02830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JW646_02830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW646_02835	COG1105	Belongs to the carbohydrate kinase PfkB family
JW646_02840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW646_02840	COG3711	transcriptional antiterminator
JW646_02865	COG0656	L-ascorbic acid biosynthetic process
JW646_02870	COG0095	Lipoate-protein ligase
JW646_02875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JW646_02885	COG0778	Nitroreductase
JW646_02890	COG0583	DNA-binding transcription factor activity
JW646_02900	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JW646_02910	COG1595	DNA-templated transcription, initiation
JW646_02915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JW646_02925	COG1525	nuclease
JW646_02935	COG2357	RelA SpoT domain protein
JW646_02950	COG3842	ATPase activity
JW646_02960	COG1177	transmembrane transport
JW646_02965	COG4134	Bacterial extracellular solute-binding protein
JW646_02975	COG0398	Pfam SNARE associated Golgi protein
JW646_02985	COG1136	(ABC) transporter
JW646_02990	COG0577	efflux transmembrane transporter activity
JW646_03005	COG0398	Pfam SNARE associated Golgi protein
JW646_03020	COG1215	transferase activity, transferring glycosyl groups
JW646_03025	COG2897	thiosulfate sulfurtransferase activity
JW646_03035	COG3875	lactate racemase activity
JW646_03050	COG0436	Aminotransferase
JW646_03075	COG2364	Membrane
JW646_03090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JW646_03100	COG2815	serine threonine protein kinase
JW646_03100	COG0515	serine threonine protein kinase
JW646_03110	COG2176	DNA-directed DNA polymerase activity
JW646_03115	COG0739	heme binding
JW646_03120	COG2177	Part of the ABC transporter FtsEX involved in
JW646_03125	COG2884	Cell division ATP-binding protein ftsE
JW646_03130	COG1404	Belongs to the peptidase S8 family
JW646_03140	COG2176	DNA-directed DNA polymerase activity
JW646_03145	COG0037	tRNA processing
JW646_03160	COG3546	catalase activity
JW646_03175	COG0860	N-Acetylmuramoyl-L-alanine amidase
JW646_03190	COG0791	NLP P60 protein
JW646_03195	COG0463	Glycosyl transferase, family 2
JW646_03200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JW646_03205	COG1376	ErfK ybiS ycfS ynhG family protein
JW646_03225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JW646_03230	COG1114	Component of the transport system for branched-chain amino acids
JW646_03235	COG3584	3D domain protein
JW646_03235	COG1388	LysM domain
JW646_03240	COG1937	Protein conserved in bacteria
JW646_03245	COG0534	Mate efflux family protein
JW646_03250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JW646_03255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JW646_03260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JW646_03265	COG0302	gtp cyclohydrolase
JW646_03290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JW646_03305	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JW646_03310	COG1744	ABC transporter substrate-binding protein PnrA-like
JW646_03315	COG2207	Transcriptional regulator
JW646_03315	COG4753	response regulator
JW646_03320	COG2972	Histidine kinase
JW646_03330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JW646_03340	COG1151	hydroxylamine reductase activity
JW646_03360	COG0659	secondary active sulfate transmembrane transporter activity
JW646_03380	COG4166	transmembrane transport
JW646_03385	COG4608	Belongs to the ABC transporter superfamily
JW646_03390	COG0444	Belongs to the ABC transporter superfamily
JW646_03395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JW646_03400	COG0601	transmembrane transport
JW646_03405	COG0534	Mate efflux family protein
JW646_03410	COG1120	ATPase activity
JW646_03415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW646_03420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW646_03430	COG2205	protein histidine kinase activity
JW646_03430	COG2202	Pas domain
JW646_03445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JW646_03455	COG1104	cysteine desulfurase activity
JW646_03460	COG2068	MobA-Related Protein
JW646_03465	COG3608	succinylglutamate desuccinylase aspartoacylase
JW646_03465	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JW646_03475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JW646_03505	COG1794	racemase activity, acting on amino acids and derivatives
JW646_03515	COG2201	protein-glutamate methylesterase activity
JW646_03525	COG0835	chemotaxis
JW646_03530	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
JW646_03535	COG1776	CheC inhibitor of MCP methylation
JW646_03540	COG2201	protein-glutamate methylesterase activity
JW646_03545	COG0643	Histidine kinase
JW646_03545	COG2198	Histidine kinase
JW646_03550	COG0840	transmembrane signaling receptor activity
JW646_03565	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JW646_03565	COG1776	CheC inhibitor of MCP methylation
JW646_03580	COG4786	Flagellar basal body rod
JW646_03585	COG1191	sigma factor activity
JW646_03590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JW646_03595	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JW646_03605	COG1338	Plays a role in the flagellum-specific transport system
JW646_03615	COG1360	Flagellar Motor Protein
JW646_03620	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JW646_03625	COG4786	Flagellar basal body rod
JW646_03645	COG1157	protein secretion by the type III secretion system
JW646_03655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JW646_03660	COG1766	The M ring may be actively involved in energy transduction
JW646_03665	COG1677	Flagellar hook-basal body complex protein FliE
JW646_03740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JW646_03745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JW646_03750	COG0457	Tetratricopeptide repeat
JW646_03750	COG0463	Glycosyl transferase, family 2
JW646_03755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JW646_03765	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JW646_03780	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
JW646_03790	COG1256	bacterial-type flagellum assembly
JW646_03790	COG4786	Flagellar basal body rod
JW646_03815	COG0741	lytic transglycosylase activity
JW646_03820	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JW646_03835	COG1918	ferrous iron import across plasma membrane
JW646_03875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW646_03875	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JW646_03875	COG0674	pyruvate-flavodoxin oxidoreductase activity
JW646_03875	COG1013	pyruvate-flavodoxin oxidoreductase activity
JW646_03880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JW646_03885	COG4869	propanediol catabolic process
JW646_03890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JW646_03900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JW646_03905	COG1757	Na H antiporter
JW646_03910	COG4187	Peptidase family M20/M25/M40
JW646_03915	COG1115	amino acid carrier protein
JW646_03920	COG3457	Alanine racemase
JW646_03930	COG5012	cobalamin binding
JW646_03940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JW646_03950	COG3804	dihydrodipicolinate reductase
JW646_03955	COG3829	transcription factor binding
JW646_03990	COG1971	Probably functions as a manganese efflux pump
JW646_04000	COG2081	HI0933 family
JW646_04005	COG0671	phosphoesterase, PA-phosphatase related
JW646_04010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JW646_04015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JW646_04020	COG0328	RNA-DNA hybrid ribonuclease activity
JW646_04020	COG3341	Caulimovirus viroplasmin
JW646_04025	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JW646_04040	COG1272	protein, Hemolysin III
JW646_04060	COG0028	Belongs to the TPP enzyme family
JW646_04065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JW646_04105	COG0489	protein tyrosine kinase activity
JW646_04120	COG0446	pyridine nucleotide-disulphide oxidoreductase
JW646_04125	COG2203	Gaf domain
JW646_04125	COG2199	diguanylate cyclase activity
JW646_04140	COG0740	serine-type endopeptidase activity
JW646_04155	COG1376	ErfK ybiS ycfS ynhG family protein
JW646_04185	COG5001	Diguanylate cyclase
JW646_04205	COG1316	TRANSCRIPTIONal
JW646_04250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JW646_04255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JW646_04295	COG2801	Transposase and inactivated derivatives
JW646_04305	COG0562	UDP-galactopyranose mutase
JW646_04330	COG0438	transferase activity, transferring glycosyl groups
JW646_04340	COG3475	LICD family
JW646_04355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JW646_04360	COG0489	protein tyrosine kinase activity
JW646_04370	COG1408	metallophosphoesterase
JW646_04380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JW646_04415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JW646_04430	COG2204	response regulator
JW646_04435	COG5002	protein histidine kinase activity
JW646_04440	COG2197	response regulator
JW646_04450	COG0681	Belongs to the peptidase S26 family
JW646_04495	COG0674	pyruvate-flavodoxin oxidoreductase activity
JW646_04495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JW646_04505	COG2223	nitrite transmembrane transporter activity
JW646_04510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JW646_04515	COG0280	phosphate acetyltransferase
JW646_04525	COG1757	Na H antiporter
JW646_04530	COG1414	Transcriptional regulator
JW646_04540	COG1316	TRANSCRIPTIONal
JW646_04550	COG0800	Aldolase
JW646_04555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JW646_04555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JW646_04565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JW646_04570	COG1063	alcohol dehydrogenase
JW646_04580	COG0246	Mannitol dehydrogenase
JW646_04585	COG2721	sulfolactate sulfo-lyase activity
JW646_04590	COG2234	aminopeptidase activity
JW646_04590	COG4935	Belongs to the peptidase S8 family
JW646_04625	COG1132	(ABC) transporter
JW646_04630	COG0535	radical SAM domain protein
JW646_04650	COG0728	peptidoglycan biosynthetic process
JW646_04670	COG0484	heat shock protein binding
JW646_04680	COG1408	metallophosphoesterase
JW646_04730	COG0438	transferase activity, transferring glycosyl groups
JW646_04740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JW646_04765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JW646_04770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JW646_04775	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JW646_04780	COG2195	Cleaves the N-terminal amino acid of tripeptides
JW646_04785	COG1288	antiporter activity
JW646_04830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JW646_04830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JW646_04830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW646_04850	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JW646_04855	COG1177	transmembrane transport
JW646_04865	COG3842	ATPase activity
JW646_04870	COG1476	TRANSCRIPTIONal
JW646_04900	COG1136	(ABC) transporter
JW646_04920	COG0572	uridine kinase
JW646_04955	COG0352	thiamine-phosphate diphosphorylase activity
JW646_04965	COG2022	thiamine diphosphate biosynthetic process
JW646_04970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JW646_04980	COG0281	malic enzyme
JW646_04990	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JW646_05000	COG1533	DNA photolyase activity
JW646_05020	COG1136	(ABC) transporter
JW646_05025	COG0577	efflux transmembrane transporter activity
JW646_05030	COG3290	protein histidine kinase activity
JW646_05035	COG3279	Response regulator of the LytR AlgR family
JW646_05040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JW646_05090	COG1309	transcriptional regulator
JW646_05110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JW646_05125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JW646_05135	COG2814	Major facilitator Superfamily
JW646_05160	COG0579	oxidoreductase
JW646_05195	COG3853	Toxic anion resistance protein (TelA)
JW646_05210	COG2310	stress, protein
JW646_05235	COG3775	system Galactitol-specific IIC component
JW646_05240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW646_05245	COG3414	Phosphotransferase system galactitol-specific IIB component
JW646_05250	COG3711	transcriptional antiterminator
JW646_05250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW646_05260	COG0006	proline dipeptidase activity
JW646_05270	COG1116	anion transmembrane transporter activity
JW646_05275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JW646_05305	COG1131	(ABC) transporter
JW646_05315	COG1744	ABC transporter substrate-binding protein PnrA-like
JW646_05320	COG3706	GGDEF domain
JW646_05325	COG0670	Belongs to the BI1 family
JW646_05330	COG0786	glutamate:sodium symporter activity
JW646_05340	COG1115	amino acid carrier protein
JW646_05375	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JW646_05380	COG0511	ligase activity, forming carbon-carbon bonds
JW646_05380	COG5016	pyruvate
JW646_05395	COG1802	Transcriptional regulator
JW646_05405	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
JW646_05420	COG3051	citrate lyase alpha subunit
JW646_05425	COG2301	Belongs to the HpcH HpaI aldolase family
JW646_05440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JW646_05450	COG0628	permease
JW646_05455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JW646_05465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JW646_05470	COG0539	negative regulation of cytoplasmic translation
JW646_05475	COG1489	DNA binding
JW646_05485	COG2059	Chromate
JW646_05495	COG1132	(ABC) transporter
JW646_05520	COG2116	formate transmembrane transporter activity
JW646_05535	COG3118	belongs to the thioredoxin family
JW646_05575	COG1940	carbohydrate kinase activity
JW646_05580	COG1609	Transcriptional regulator
JW646_05590	COG2078	PFAM AMMECR1 domain protein
JW646_05590	COG3885	ferrous iron binding
JW646_05600	COG4607	ABC-type enterochelin transport system periplasmic component
JW646_05605	COG4604	ABC transporter, ATP-binding protein
JW646_05610	COG4605	iron ion homeostasis
JW646_05615	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW646_05620	COG0622	Phosphoesterase
JW646_05625	COG0789	Transcriptional regulator
JW646_05625	COG4978	Transcriptional regulator
JW646_05630	COG0513	Belongs to the DEAD box helicase family
JW646_05640	COG1846	Transcriptional regulator
JW646_05645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JW646_05655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JW646_05660	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JW646_05665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JW646_05675	COG3732	PTS system glucitol sorbitol-specific
JW646_05680	COG3730	PTS system glucitol sorbitol-specific
JW646_05690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW646_05690	COG3711	transcriptional antiterminator
JW646_05735	COG3118	belongs to the thioredoxin family
JW646_05750	COG1950	PFAM Membrane protein of
JW646_05755	COG0704	Plays a role in the regulation of phosphate uptake
JW646_05760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JW646_05765	COG0581	inorganic phosphate transmembrane transporter activity
JW646_05770	COG0573	inorganic phosphate transmembrane transporter activity
JW646_05775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JW646_05800	COG0641	radical SAM
JW646_05810	COG1472	Belongs to the glycosyl hydrolase 3 family
JW646_05840	COG0842	Transport permease protein
JW646_05855	COG1114	Component of the transport system for branched-chain amino acids
JW646_05870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JW646_05885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JW646_05890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JW646_05890	COG1648	precorrin-2 dehydrogenase activity
JW646_05900	COG0113	porphobilinogen synthase activity
JW646_05910	COG0181	hydroxymethylbilane synthase activity
JW646_05950	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
JW646_05965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JW646_05975	COG1797	cobyrinic acid a,c-diamide synthase activity
JW646_05980	COG1492	cobalamin metabolic process
JW646_05985	COG1122	ATPase activity
JW646_06015	COG0745	RESPONSE REGULATOR receiver
JW646_06020	COG5002	protein histidine kinase activity
JW646_06055	COG0789	Transcriptional regulator
JW646_06055	COG4978	Transcriptional regulator
JW646_06060	COG1966	Carbon starvation protein
JW646_06065	COG3279	Response regulator of the LytR AlgR family
JW646_06070	COG3275	phosphorelay sensor kinase activity
JW646_06075	COG1827	regulation of RNA biosynthetic process
JW646_06080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JW646_06090	COG0157	Belongs to the NadC ModD family
JW646_06095	COG1476	TRANSCRIPTIONal
JW646_06110	COG2205	protein histidine kinase activity
JW646_06125	COG0745	RESPONSE REGULATOR receiver
JW646_06135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JW646_06140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JW646_06145	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
JW646_06155	COG0577	efflux transmembrane transporter activity
JW646_06160	COG1136	(ABC) transporter
JW646_06165	COG2205	protein histidine kinase activity
JW646_06170	COG0745	RESPONSE REGULATOR receiver
JW646_06180	COG0673	inositol 2-dehydrogenase activity
JW646_06185	COG0191	fructose-bisphosphate aldolase activity
JW646_06190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW646_06215	COG1131	(ABC) transporter
JW646_06220	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JW646_06225	COG4770	biotin carboxylase activity
JW646_06235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JW646_06245	COG1703	isobutyryl-CoA mutase activity
JW646_06250	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JW646_06250	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JW646_06255	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JW646_06255	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JW646_06260	COG0427	acetyl-CoA hydrolase
JW646_06270	COG0583	DNA-binding transcription factor activity
JW646_06280	COG0583	DNA-binding transcription factor activity
JW646_06285	COG3949	Membrane
JW646_06305	COG1215	transferase activity, transferring glycosyl groups
JW646_06350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JW646_06355	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JW646_06370	COG0789	Transcriptional regulator
JW646_06375	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JW646_06400	COG0436	Aminotransferase
JW646_06420	COG0534	Mate efflux family protein
JW646_06435	COG1773	rubredoxin
JW646_06435	COG1592	Rubrerythrin
JW646_06440	COG1959	2 iron, 2 sulfur cluster binding
JW646_06445	COG0517	IMP dehydrogenase activity
JW646_06445	COG1125	glycine betaine transport
JW646_06455	COG1174	glycine betaine transport
JW646_06470	COG0542	response to heat
JW646_06490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JW646_06495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JW646_06505	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW646_06525	COG0825	malonyl-CoA metabolic process
JW646_06535	COG0439	Biotin carboxylase
JW646_06545	COG0511	ligase activity, forming carbon-carbon bonds
JW646_06550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JW646_06555	COG1028	Short-chain dehydrogenase reductase Sdr
JW646_06560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JW646_06575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JW646_06580	COG0736	holo-[acyl-carrier-protein] synthase activity
JW646_06585	COG1454	alcohol dehydrogenase
JW646_06585	COG1012	belongs to the aldehyde dehydrogenase family
JW646_06590	COG1120	ATPase activity
JW646_06595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW646_06645	COG2011	ABC-type metal ion transport system permease component
JW646_06650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JW646_06655	COG1464	Belongs to the NlpA lipoprotein family
JW646_06660	COG2205	protein histidine kinase activity
JW646_06665	COG0745	RESPONSE REGULATOR receiver
JW646_06670	COG3118	belongs to the thioredoxin family
JW646_06680	COG0386	Belongs to the glutathione peroxidase family
JW646_06685	COG1846	Transcriptional regulator
JW646_06695	COG5002	protein histidine kinase activity
JW646_06710	COG1414	Transcriptional regulator
JW646_06715	COG0039	L-malate dehydrogenase activity
JW646_06720	COG3314	Sporulation integral membrane protein YlbJ
JW646_06780	COG2011	ABC-type metal ion transport system permease component
JW646_06785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JW646_06790	COG1105	Belongs to the carbohydrate kinase PfkB family
JW646_06805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JW646_06810	COG2222	sugar isomerase
JW646_06815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW646_06830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW646_06835	COG3715	PTS system
JW646_06840	COG3716	PTS system mannose fructose sorbose family IID component
JW646_06845	COG1136	(ABC) transporter
JW646_06850	COG0577	efflux transmembrane transporter activity
JW646_06855	COG0784	Response regulator, receiver
JW646_06855	COG2205	protein histidine kinase activity
JW646_06860	COG0745	RESPONSE REGULATOR receiver
JW646_06870	COG3708	Transcriptional regulator
JW646_06870	COG2207	Transcriptional regulator
JW646_06880	COG2252	PERMEase
JW646_06990	COG2003	Belongs to the UPF0758 family
JW646_07025	COG0582	viral genome integration into host DNA
JW646_07055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JW646_07085	COG4608	Belongs to the ABC transporter superfamily
JW646_07090	COG0444	Belongs to the ABC transporter superfamily
JW646_07095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JW646_07100	COG0601	transmembrane transport
JW646_07105	COG2205	protein histidine kinase activity
JW646_07110	COG0745	RESPONSE REGULATOR receiver
JW646_07115	COG0577	efflux transmembrane transporter activity
JW646_07120	COG1136	(ABC) transporter
JW646_07130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JW646_07145	COG1876	peptidase activity
JW646_07150	COG1151	hydroxylamine reductase activity
JW646_07160	COG0557	exoribonuclease II activity
JW646_07180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW646_07180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JW646_07185	COG1607	acyl-coa hydrolase
JW646_07190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JW646_07195	COG2086	electron transfer activity
JW646_07200	COG1960	acyl-CoA dehydrogenase activity
JW646_07205	COG1609	Transcriptional regulator
JW646_07210	COG0469	pyruvate kinase activity
JW646_07215	COG0148	phosphopyruvate hydratase activity
JW646_07220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JW646_07225	COG0149	triose-phosphate isomerase activity
JW646_07230	COG0126	phosphoglycerate kinase activity
JW646_07240	COG2390	Transcriptional regulator
JW646_07260	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
JW646_07265	COG0584	glycerophosphoryl diester phosphodiesterase
JW646_07270	COG1115	amino acid carrier protein
JW646_07275	COG1126	abc transporter atp-binding protein
JW646_07290	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JW646_07370	COG1131	(ABC) transporter
JW646_07375	COG1725	Transcriptional regulator
JW646_07380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JW646_07385	COG2226	methyltransferase
JW646_07395	COG1473	amidohydrolase
JW646_07405	COG5002	protein histidine kinase activity
JW646_07420	COG0577	efflux transmembrane transporter activity
JW646_07420	COG1136	(ABC) transporter
JW646_07430	COG1760	l-serine dehydratase
JW646_07435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JW646_07445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JW646_07450	COG2171	N-acyltransferase activity
JW646_07465	COG1380	Effector of murein hydrolase LrgA
JW646_07480	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JW646_07485	COG3681	Belongs to the UPF0597 family
JW646_07490	COG3829	transcription factor binding
JW646_07540	COG0726	polysaccharide deacetylase
JW646_07555	COG0704	Plays a role in the regulation of phosphate uptake
JW646_07560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JW646_07565	COG0581	inorganic phosphate transmembrane transporter activity
JW646_07570	COG0573	inorganic phosphate transmembrane transporter activity
JW646_07575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JW646_07585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JW646_07595	COG1164	Oligoendopeptidase f
JW646_07600	COG1285	pathogenesis
JW646_07605	COG0668	transmembrane transport
JW646_07640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JW646_07645	COG0166	Belongs to the GPI family
JW646_07655	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
JW646_07690	COG1459	type II secretion system
JW646_07695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JW646_07705	COG0835	chemotaxis
JW646_07705	COG0784	Response regulator, receiver
JW646_07710	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JW646_07715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JW646_07720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JW646_07725	COG0740	serine-type endopeptidase activity
JW646_07730	COG0544	peptidyl-prolyl cis-trans isomerase activity
JW646_07745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JW646_07780	COG1151	hydroxylamine reductase activity
JW646_07810	COG4106	trans-aconitate 2-methyltransferase activity
JW646_07815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JW646_07820	COG0426	domain, Protein
JW646_07845	COG0733	neurotransmitter:sodium symporter activity
JW646_07855	COG0205	6-phosphofructokinase activity
JW646_07865	COG1481	regulation of sporulation
JW646_07880	COG1660	Displays ATPase and GTPase activities
JW646_07885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JW646_07890	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JW646_07900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW646_07910	COG0493	'glutamate synthase
JW646_07910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JW646_07915	COG2116	formate transmembrane transporter activity
JW646_07920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JW646_07925	COG0521	Mo-molybdopterin cofactor biosynthetic process
JW646_07940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JW646_07945	COG0303	'Molybdopterin
JW646_07975	COG2357	RelA SpoT domain protein
JW646_08000	COG1227	inorganic diphosphatase activity
JW646_08005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JW646_08010	COG1362	aminopeptidase activity
JW646_08015	COG0210	DNA helicase
JW646_08030	COG1454	alcohol dehydrogenase
JW646_08035	COG0588	phosphoglycerate mutase activity
JW646_08040	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JW646_08045	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
JW646_08050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JW646_08060	COG0793	Belongs to the peptidase S41A family
JW646_08060	COG3409	Peptidoglycan-binding domain 1 protein
JW646_08065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JW646_08070	COG0840	transmembrane signaling receptor activity
JW646_08080	COG3958	Transketolase
JW646_08085	COG3959	Transketolase, thiamine diphosphate binding domain
JW646_08090	COG2337	Toxic component of a toxin-antitoxin (TA) module
JW646_08105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JW646_08110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JW646_08115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JW646_08120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JW646_08125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JW646_08130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JW646_08155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JW646_08160	COG0698	ribose 5-phosphate isomerase
JW646_08165	COG0009	L-threonylcarbamoyladenylate synthase
JW646_08175	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JW646_08180	COG2890	protein-(glutamine-N5) methyltransferase activity
JW646_08185	COG3872	metal-dependent enzyme
JW646_08190	COG1435	thymidine kinase activity
JW646_08195	COG0254	rRNA binding
JW646_08200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JW646_08205	COG1494	fructose-1,6-bisphosphatase
JW646_08210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JW646_08215	COG1164	Oligoendopeptidase f
JW646_08220	COG2208	phosphoserine phosphatase activity
JW646_08225	COG0248	Ppx GppA phosphatase
JW646_08225	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JW646_08245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JW646_08250	COG0776	regulation of translation
JW646_08255	COG3956	TIGRFAM MazG family protein
JW646_08260	COG2244	polysaccharide biosynthetic process
JW646_08265	COG2002	toxin-antitoxin pair type II binding
JW646_08270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JW646_08275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JW646_08280	COG0193	aminoacyl-tRNA hydrolase activity
JW646_08300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JW646_08305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JW646_08310	COG2088	sporulation resulting in formation of a cellular spore
JW646_08315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JW646_08320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JW646_08345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JW646_08350	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JW646_08380	COG0644	oxidoreductase
JW646_08385	COG0706	membrane insertase activity
JW646_08430	COG1131	(ABC) transporter
JW646_08435	COG1725	Transcriptional regulator
JW646_08445	COG0084	hydrolase, TatD family'
JW646_08450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW646_08450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW646_08455	COG0700	Nucleoside recognition
JW646_08465	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JW646_08470	COG1522	sequence-specific DNA binding
JW646_08480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JW646_08485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JW646_08490	COG1774	PSP1 C-terminal conserved region
JW646_08495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JW646_08505	COG1982	Orn Lys Arg decarboxylase major
JW646_08575	COG5002	protein histidine kinase activity
JW646_08595	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JW646_08600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JW646_08600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JW646_08615	COG1592	Rubrerythrin
JW646_08620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JW646_08625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JW646_08630	COG0101	tRNA pseudouridine synthase activity
JW646_08635	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JW646_08640	COG1122	ATPase activity
JW646_08645	COG1122	ATPase activity
JW646_08650	COG0203	ribosomal protein L17
JW646_08655	COG0202	RNA polymerase activity
JW646_08660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JW646_08665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JW646_08670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JW646_08675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JW646_08680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JW646_08685	COG0024	Methionine aminopeptidase
JW646_08690	COG0563	adenylate kinase activity
JW646_08700	COG0200	Binds to the 23S rRNA
JW646_08705	COG1841	ribosomal large subunit assembly
JW646_08710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JW646_08715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JW646_08720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JW646_08725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JW646_08730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JW646_08735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JW646_08740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JW646_08745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JW646_08750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JW646_08755	COG0255	Belongs to the universal ribosomal protein uL29 family
JW646_08760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JW646_08765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JW646_08770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JW646_08775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JW646_08780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JW646_08785	COG0089	rRNA binding
JW646_08790	COG0088	Forms part of the polypeptide exit tunnel
JW646_08795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JW646_08800	COG0051	transcription antitermination factor activity, RNA binding
JW646_08805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JW646_08810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JW646_08815	COG0049	tRNA binding
JW646_08820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JW646_08825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JW646_08830	COG0085	RNA polymerase activity
JW646_08835	COG0222	ribosome binding
JW646_08840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JW646_08845	COG0081	regulation of translation
JW646_08850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JW646_08855	COG0250	Participates in transcription elongation, termination and antitermination
JW646_08865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JW646_08870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JW646_08880	COG3688	RNA-binding protein containing a PIN domain
JW646_08885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JW646_08900	COG0215	cysteine-tRNA ligase activity
JW646_08905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JW646_08910	COG0442	prolyl-tRNA aminoacylation
JW646_08915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JW646_08920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JW646_08925	COG4956	integral membrane protein (PIN domain superfamily)
JW646_08930	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
JW646_08935	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JW646_08940	COG0542	response to heat
JW646_08945	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JW646_08955	COG4463	regulation of RNA biosynthetic process
JW646_08960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JW646_08965	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JW646_09205	COG1393	Belongs to the ArsC family
JW646_09220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JW646_09225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JW646_09230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JW646_09245	COG0590	tRNA wobble adenosine to inosine editing
JW646_09270	COG3842	ATPase activity
JW646_09300	COG0058	SHG alpha-glucan phosphorylase activity
JW646_09335	COG1191	sigma factor activity
JW646_09340	COG2172	sigma factor antagonist activity
JW646_09360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JW646_09365	COG0187	DNA topoisomerase II activity
JW646_09370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JW646_09380	COG0592	DNA-directed DNA polymerase activity
JW646_09385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JW646_09390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JW646_09395	COG0594	ribonuclease P activity
JW646_09400	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JW646_09405	COG0706	membrane insertase activity
JW646_09410	COG1847	R3H domain protein
JW646_09415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JW646_09420	COG0445	tRNA wobble uridine modification
JW646_09425	COG0357	Ribosomal RNA small subunit methyltransferase G
JW646_09430	COG1475	DNA binding
JW646_09435	COG1192	Involved in chromosome partitioning
JW646_09440	COG1475	DNA binding
JW646_09450	COG4481	Protein conserved in bacteria
JW646_09455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JW646_09460	COG0360	Binds together with S18 to 16S ribosomal RNA
JW646_09465	COG0629	single-stranded DNA binding
JW646_09470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JW646_09485	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JW646_09490	COG0359	binds to the 23S rRNA
JW646_09495	COG0305	Participates in initiation and elongation during chromosome replication
JW646_09505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JW646_09525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JW646_09530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JW646_09550	COG0037	tRNA processing
JW646_09555	COG4619	ABC transporter
JW646_09560	COG0390	transport system, permease component
JW646_09585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW646_09585	COG3711	transcriptional antiterminator
JW646_09605	COG3959	Transketolase, thiamine diphosphate binding domain
JW646_09610	COG3958	Transketolase
JW646_09620	COG2824	Alkylphosphonate utilization operon protein PhnA
JW646_09650	COG1854	S-ribosylhomocysteine lyase activity
JW646_09660	COG1410	methionine synthase
JW646_09660	COG0646	methionine synthase
JW646_09675	COG0284	orotidine-5'-phosphate decarboxylase activity
JW646_09695	COG0116	Belongs to the methyltransferase superfamily
JW646_09695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JW646_09700	COG0564	pseudouridine synthase activity
JW646_09710	COG0653	protein targeting
JW646_09730	COG4466	Protein conserved in bacteria
JW646_09740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JW646_09745	COG1802	Transcriptional regulator
JW646_09755	COG3409	Peptidoglycan-binding domain 1 protein
JW646_09755	COG3773	Cell wall hydrolase
JW646_09765	COG0037	tRNA processing
JW646_09770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JW646_09780	COG3191	aminopeptidase activity
JW646_09790	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JW646_09800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JW646_09805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JW646_09845	COG0602	queuosine metabolic process
JW646_10015	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JW646_10025	COG0280	phosphate acetyltransferase
JW646_10045	COG0674	pyruvate-flavodoxin oxidoreductase activity
JW646_10060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JW646_10075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JW646_10080	COG2385	sporulation resulting in formation of a cellular spore
JW646_10090	COG1609	Transcriptional regulator
JW646_10095	COG1077	Cell shape determining protein MreB Mrl
JW646_10105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JW646_10110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JW646_10115	COG1040	competence protein
JW646_10120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JW646_10130	COG0653	protein targeting
JW646_10140	COG2183	response to ionizing radiation
JW646_10145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JW646_10150	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
JW646_10155	COG0802	atpase or kinase
JW646_10160	COG1214	PFAM Peptidase M22, glycoprotease
JW646_10165	COG0456	acetyltransferase
JW646_10170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JW646_10180	COG0488	(ABC) transporter
JW646_10185	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JW646_10200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JW646_10205	COG0540	Belongs to the ATCase OTCase family
JW646_10210	COG0543	2 iron, 2 sulfur cluster binding
JW646_10215	COG0167	dihydroorotate dehydrogenase activity
JW646_10220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JW646_10230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JW646_10240	COG3594	Acyltransferase
JW646_10250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JW646_10255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JW646_10260	COG3475	LICD family
JW646_10275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JW646_10280	COG0459	protein refolding
JW646_10285	COG1691	(AIR) carboxylase
JW646_10290	COG0516	GMP reductase activity
JW646_10290	COG0517	IMP dehydrogenase activity
JW646_10295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JW646_10295	COG0519	Catalyzes the synthesis of GMP from XMP
JW646_10300	COG1744	ABC transporter substrate-binding protein PnrA-like
JW646_10305	COG2252	PERMEase
JW646_10315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JW646_10320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JW646_10325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JW646_10330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JW646_10335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JW646_10340	COG0138	bifunctional purine biosynthesis protein purh
JW646_10345	COG0151	Belongs to the GarS family
JW646_10365	COG1595	DNA-templated transcription, initiation
JW646_10375	COG1131	(ABC) transporter
JW646_10390	COG4656	Part of a membrane complex involved in electron transport
JW646_10395	COG5275	peptidyl-tyrosine sulfation
JW646_10395	COG0252	asparaginase activity
JW646_10405	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
JW646_10410	COG0252	asparaginase activity
JW646_10410	COG5275	peptidyl-tyrosine sulfation
JW646_10415	COG0071	Belongs to the small heat shock protein (HSP20) family
JW646_10425	COG1309	transcriptional regulator
JW646_10430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JW646_10495	COG2217	Heavy metal translocating P-type atpase
JW646_10550	COG0556	nucleotide-excision repair
JW646_10560	COG0322	excinuclease ABC activity
JW646_10590	COG1187	pseudouridine synthase activity
JW646_10600	COG2267	carboxylic ester hydrolase activity
JW646_10615	COG0561	phosphatase activity
JW646_10645	COG2339	peptidase activity
JW646_10655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JW646_10665	COG0667	Aldo Keto reductase
JW646_10670	COG2066	Belongs to the glutaminase family
JW646_10680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JW646_10685	COG1067	ATP-dependent peptidase activity
JW646_10690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JW646_10695	COG2720	vancomycin resistance protein
JW646_10700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JW646_10705	COG1307	EDD domain protein, DegV family
JW646_10710	COG1744	ABC transporter substrate-binding protein PnrA-like
JW646_10715	COG3845	ABC transporter
JW646_10720	COG4603	Belongs to the binding-protein-dependent transport system permease family
JW646_10725	COG1079	Belongs to the binding-protein-dependent transport system permease family
JW646_10735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JW646_10745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JW646_10750	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JW646_10755	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JW646_10760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JW646_10765	COG0569	domain protein
JW646_10770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JW646_10775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JW646_10780	COG0072	phenylalanine-tRNA ligase activity
JW646_10780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JW646_10790	COG0826	peptidase U32
JW646_10795	COG2195	Cleaves the N-terminal amino acid of tripeptides
JW646_10800	COG1193	negative regulation of DNA recombination
JW646_10805	COG1683	Conserved Protein
JW646_10810	COG0018	arginyl-trna synthetase
JW646_10835	COG1151	hydroxylamine reductase activity
JW646_10845	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JW646_10850	COG3404	Formiminotransferase-cyclodeaminase
JW646_10855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JW646_10865	COG0646	methionine synthase
JW646_10865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JW646_10870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JW646_10890	COG0646	methionine synthase
JW646_10890	COG1410	methionine synthase
JW646_10900	COG0509	glycine decarboxylation via glycine cleavage system
JW646_10915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW646_10920	COG1120	ATPase activity
JW646_10965	COG0210	DNA helicase
JW646_10970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JW646_10975	COG0765	amino acid transport
JW646_10980	COG1126	abc transporter atp-binding protein
JW646_10990	COG1104	cysteine desulfurase activity
JW646_10995	COG0301	tRNA thio-modification
JW646_11000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JW646_11010	COG0530	calcium, potassium:sodium antiporter activity
JW646_11020	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
JW646_11035	COG1191	sigma factor activity
JW646_11045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JW646_11060	COG0750	zinc metalloprotease
JW646_11070	COG0860	N-Acetylmuramoyl-L-alanine amidase
JW646_11080	COG0488	(ABC) transporter
JW646_11100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JW646_11115	COG1739	Uncharacterized protein family UPF0029
JW646_11125	COG0730	response to heat
JW646_11130	COG0730	response to heat
JW646_11135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JW646_11140	COG0217	transcriptional regulatory protein
JW646_11180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JW646_11185	COG0632	four-way junction helicase activity
JW646_11190	COG2255	four-way junction helicase activity
JW646_11195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JW646_11205	COG0343	queuine tRNA-ribosyltransferase activity
JW646_11210	COG1862	Preprotein translocase
JW646_11235	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JW646_11235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JW646_11240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JW646_11245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JW646_11250	COG1490	D-aminoacyl-tRNA deacylase activity
JW646_11255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JW646_11260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JW646_11265	COG0124	histidyl-tRNA synthetase
JW646_11270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JW646_11275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JW646_11280	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JW646_11310	COG1328	CTP reductase activity
JW646_11325	COG0602	queuosine metabolic process
JW646_11345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JW646_11375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JW646_11375	COG2199	diguanylate cyclase activity
JW646_11385	COG2190	(PTS) system
JW646_11385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW646_11385	COG1263	PTS System
JW646_11390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JW646_11395	COG1842	Phage shock protein A
JW646_11405	COG4260	virion core protein, lumpy skin disease virus
JW646_11425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JW646_11435	COG0446	pyridine nucleotide-disulphide oxidoreductase
JW646_11460	COG0656	L-ascorbic acid biosynthetic process
JW646_11465	COG1191	sigma factor activity
JW646_11470	COG5183	chlorophyll binding
JW646_11470	COG2133	pyrroloquinoline quinone binding
JW646_11475	COG1671	Belongs to the UPF0178 family
JW646_11505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JW646_11520	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JW646_11530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JW646_11530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JW646_11550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JW646_11555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JW646_11560	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JW646_11565	COG0297	glycogen (starch) synthase activity
JW646_11570	COG0058	SHG alpha-glucan phosphorylase activity
JW646_11580	COG0629	single-stranded DNA binding
JW646_11585	COG5002	protein histidine kinase activity
JW646_11615	COG3426	butyrate kinase activity
JW646_11620	COG0789	Transcriptional regulator
JW646_11620	COG4978	Transcriptional regulator
JW646_11625	COG0280	phosphate acetyltransferase
JW646_11680	COG2195	Cleaves the N-terminal amino acid of tripeptides
JW646_11710	COG0534	Mate efflux family protein
JW646_11720	COG1473	amidohydrolase
JW646_11730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JW646_11740	COG4868	Belongs to the UPF0371 family
JW646_11745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JW646_11750	COG1230	cation diffusion facilitator family transporter
JW646_11755	COG3086	response to oxidative stress
JW646_11770	COG3069	C4-dicarboxylate transmembrane transporter activity
JW646_11790	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
JW646_11795	COG1924	4 iron, 4 sulfur cluster binding
JW646_11820	COG1609	Transcriptional regulator
JW646_11825	COG1129	ABC transporter
JW646_11840	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
JW646_11855	COG0210	DNA helicase
JW646_11865	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JW646_11870	COG1074	ATP-dependent DNA helicase activity
JW646_11875	COG0420	3'-5' exonuclease activity
JW646_11880	COG0419	ATPase involved in DNA repair
JW646_11885	COG4536	flavin adenine dinucleotide binding
JW646_11895	COG0622	Phosphoesterase
JW646_11900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JW646_11905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JW646_11910	COG0564	pseudouridine synthase activity
JW646_11920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JW646_11925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW646_11930	COG1120	ATPase activity
JW646_11935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JW646_11940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW646_11945	COG1120	ATPase activity
JW646_12005	COG1086	Polysaccharide biosynthesis protein
JW646_12010	COG0110	maltose O-acetyltransferase activity
JW646_12015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JW646_12020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JW646_12030	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
JW646_12045	COG2089	acid synthase
JW646_12055	COG1215	transferase activity, transferring glycosyl groups
JW646_12110	COG0626	cystathionine gamma-synthase activity
JW646_12115	COG1136	(ABC) transporter
JW646_12120	COG0577	efflux transmembrane transporter activity
JW646_12125	COG0493	'glutamate synthase
JW646_12130	COG3584	3D domain protein
JW646_12130	COG1388	LysM domain
JW646_12135	COG0745	RESPONSE REGULATOR receiver
JW646_12140	COG2205	protein histidine kinase activity
JW646_12145	COG1136	(ABC) transporter
JW646_12160	COG0601	transmembrane transport
JW646_12165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JW646_12170	COG0444	Belongs to the ABC transporter superfamily
JW646_12175	COG4608	Belongs to the ABC transporter superfamily
JW646_12185	COG1116	anion transmembrane transporter activity
JW646_12190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JW646_12195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JW646_12205	COG0583	DNA-binding transcription factor activity
JW646_12210	COG1028	Short-chain dehydrogenase reductase Sdr
JW646_12215	COG0183	Belongs to the thiolase family
JW646_12225	COG2223	nitrite transmembrane transporter activity
JW646_12230	COG2030	dehydratase
JW646_12235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JW646_12240	COG0405	Gamma-glutamyltransferase
JW646_12245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JW646_12250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JW646_12255	COG1120	ATPase activity
JW646_12285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JW646_12300	COG0288	reversible hydration of carbon dioxide
JW646_12335	COG1104	cysteine desulfurase activity
JW646_12350	COG1674	ftsk spoiiie
JW646_12395	COG1846	Transcriptional regulator
JW646_12410	COG0494	nUDIX hydrolase
JW646_12420	COG4149	molybdate abc transporter
JW646_12425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JW646_12445	COG0537	adenosine 5'-monophosphoramidase activity
JW646_12450	COG1595	DNA-templated transcription, initiation
JW646_12480	COG0039	L-malate dehydrogenase activity
JW646_12495	COG4213	ABC transporter substrate-binding protein
JW646_12505	COG1172	Belongs to the binding-protein-dependent transport system permease family
JW646_12510	COG1940	carbohydrate kinase activity
JW646_12515	COG2115	Belongs to the xylose isomerase family
JW646_12520	COG1070	Carbohydrate kinase
JW646_12525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JW646_12535	COG0789	Transcriptional regulator
JW646_12545	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
JW646_12555	COG1695	Transcriptional regulator
JW646_12575	COG2986	histidine ammonia-lyase
JW646_12590	COG1228	amidohydrolase
JW646_12605	COG1268	BioY protein
JW646_12640	COG2244	polysaccharide biosynthetic process
JW646_12645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JW646_12650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JW646_12655	COG4224	UPF0291 protein
JW646_12660	COG1362	aminopeptidase activity
JW646_12675	COG2267	carboxylic ester hydrolase activity
JW646_12680	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JW646_12685	COG0840	transmembrane signaling receptor activity
JW646_12700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JW646_12700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JW646_12720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JW646_12730	COG3279	Response regulator of the LytR AlgR family
JW646_12740	COG4377	Putative membrane peptidase family (DUF2324)
JW646_12760	COG0346	lactoylglutathione lyase activity
JW646_12765	COG0791	NLP P60 protein
JW646_12765	COG1388	LysM domain
JW646_12765	COG3103	Sh3 type 3 domain protein
JW646_12775	COG4656	Part of a membrane complex involved in electron transport
JW646_12780	COG4658	electron transport chain
JW646_12785	COG4659	FMN binding
JW646_12790	COG4660	Part of a membrane complex involved in electron transport
JW646_12795	COG4657	Part of a membrane complex involved in electron transport
JW646_12800	COG1245	4Fe-4S binding domain
JW646_12800	COG2878	Part of a membrane complex involved in electron transport
JW646_12805	COG0424	maF-like protein
JW646_12810	COG2003	Belongs to the UPF0758 family
JW646_12815	COG1077	Cell shape determining protein MreB Mrl
JW646_12830	COG0768	penicillin binding
JW646_12835	COG0850	regulation of cytokinetic process
JW646_12840	COG2894	cell division
JW646_12845	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JW646_12850	COG0772	Belongs to the SEDS family
JW646_12855	COG1803	Methylglyoxal synthase
JW646_12860	COG0426	domain, Protein
JW646_12880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JW646_12890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JW646_12895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JW646_12915	COG3655	Transcriptional regulator
JW646_12925	COG1234	tRNA 3'-trailer cleavage
JW646_12930	COG2137	regulation of response to DNA damage stimulus
JW646_12935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JW646_12940	COG1713	HD superfamily hydrolase involved in NAD metabolism
JW646_12945	COG0799	negative regulation of ribosome biogenesis
JW646_12950	COG0495	leucyl-tRNA aminoacylation
JW646_12955	COG0251	oxidation-reduction process
JW646_12965	COG0561	phosphatase activity
JW646_12970	COG0165	Argininosuccinate lyase
JW646_12975	COG1686	Belongs to the peptidase S11 family
JW646_12980	COG1555	photosystem II stabilization
JW646_12980	COG1596	polysaccharide export
JW646_12995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JW646_13010	COG1982	Orn Lys Arg decarboxylase major
JW646_13015	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
JW646_13020	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JW646_13030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JW646_13035	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JW646_13040	COG0658	competence protein
JW646_13040	COG2333	competence protein COMEC
JW646_13055	COG2333	competence protein COMEC
JW646_13055	COG0658	competence protein
JW646_13060	COG1466	dna polymerase III delta subunit
JW646_13065	COG0268	Binds directly to 16S ribosomal RNA
JW646_13085	COG0481	GTPase activity
JW646_13090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JW646_13110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JW646_13115	COG1420	regulation of RNA biosynthetic process
JW646_13120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JW646_13125	COG0443	Heat shock 70 kDa protein
JW646_13130	COG0484	heat shock protein binding
JW646_13135	COG2264	protein methyltransferase activity
JW646_13140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JW646_13145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JW646_13150	COG0537	adenosine 5'-monophosphoramidase activity
JW646_13155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JW646_13160	COG1610	YqeY-like protein
JW646_13165	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
JW646_13180	COG1702	phosphate starvation-inducible protein PhoH
JW646_13185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JW646_13190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JW646_13195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JW646_13200	COG2239	Acts as a magnesium transporter
JW646_13205	COG1381	Involved in DNA repair and RecF pathway recombination
JW646_13215	COG0752	glycyl-tRNA synthetase alpha subunit
JW646_13220	COG0751	glycine-tRNA ligase activity
JW646_13225	COG0517	IMP dehydrogenase activity
JW646_13230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JW646_13235	COG0574	Belongs to the PEP-utilizing enzyme family
JW646_13235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JW646_13240	COG0745	RESPONSE REGULATOR receiver
JW646_13245	COG2205	protein histidine kinase activity
JW646_13270	COG0006	proline dipeptidase activity
JW646_13280	COG2195	Cleaves the N-terminal amino acid of tripeptides
JW646_13285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JW646_13285	COG0551	DNA topoisomerase type I activity
JW646_13290	COG0756	dUTP diphosphatase activity
JW646_13295	COG0860	N-Acetylmuramoyl-L-alanine amidase
JW646_13295	COG3103	Sh3 type 3 domain protein
JW646_13295	COG4991	sh3 domain protein
JW646_13300	COG0791	NLP P60 protein
JW646_13320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JW646_13340	COG4509	Sortase family
JW646_13375	COG0785	Cytochrome C biogenesis protein
JW646_13390	COG2217	Heavy metal translocating P-type atpase
JW646_13420	COG1773	rubredoxin
JW646_13420	COG1592	Rubrerythrin
JW646_13430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JW646_13435	COG0573	inorganic phosphate transmembrane transporter activity
JW646_13470	COG0310	cobalt ion transport
JW646_13480	COG0753	catalase activity
JW646_13485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JW646_13545	COG1136	(ABC) transporter
JW646_13565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW646_13575	COG0697	spore germination
JW646_13585	COG1418	mRNA catabolic process
JW646_13595	COG2409	Drug exporters of the RND superfamily
JW646_13605	COG1528	Iron-storage protein
JW646_13625	COG0561	phosphatase activity
JW646_13630	COG2197	response regulator
JW646_13680	COG1910	domain protein
JW646_13685	COG0725	ABC transporter, periplasmic molybdate-binding protein
JW646_13690	COG4149	molybdate abc transporter
JW646_13695	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JW646_13700	COG1193	negative regulation of DNA recombination
JW646_13725	COG1879	ABC-type sugar transport system periplasmic component
JW646_13730	COG1172	Belongs to the binding-protein-dependent transport system permease family
JW646_13735	COG1129	ABC transporter
JW646_13740	COG1869	D-ribose catabolic process
JW646_13745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW646_13765	COG1301	dicarboxylic acid transport
JW646_13775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JW646_13780	COG0398	Pfam SNARE associated Golgi protein
JW646_13790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JW646_13800	COG0534	Mate efflux family protein
JW646_13810	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JW646_13815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JW646_13820	COG0765	amino acid transport
JW646_13825	COG1126	abc transporter atp-binding protein
JW646_13845	COG0561	phosphatase activity
JW646_13850	COG1454	alcohol dehydrogenase
JW646_13850	COG1012	belongs to the aldehyde dehydrogenase family
JW646_13860	COG0617	tRNA 3'-terminal CCA addition
JW646_13865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JW646_13875	COG1012	belongs to the aldehyde dehydrogenase family
JW646_13875	COG1454	alcohol dehydrogenase
JW646_13885	COG3706	GGDEF domain
JW646_13890	COG1132	(ABC) transporter
JW646_13920	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JW646_13925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JW646_13930	COG0628	permease
JW646_13935	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JW646_13940	COG1984	allophanate hydrolase subunit 2
JW646_13950	COG0439	Biotin carboxylase
JW646_13955	COG4336	lyase activity
JW646_13960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JW646_13965	COG1914	H( )-stimulated, divalent metal cation uptake system
JW646_13980	COG2815	serine threonine protein kinase
JW646_13980	COG0515	serine threonine protein kinase
JW646_13995	COG0012	GTP binding
JW646_14000	COG0612	Peptidase, M16
JW646_14005	COG0612	Peptidase, M16
JW646_14010	COG4464	protein tyrosine phosphatase activity
JW646_14015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JW646_14020	COG0275	rRNA processing
JW646_14025	COG2873	o-acetylhomoserine
JW646_14030	COG0534	Mate efflux family protein
JW646_14045	COG0768	penicillin binding
JW646_14050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JW646_14055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JW646_14060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JW646_14065	COG0772	Belongs to the SEDS family
JW646_14070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JW646_14075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JW646_14085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JW646_14095	COG1191	sigma factor activity
JW646_14100	COG1191	sigma factor activity
JW646_14105	COG1873	PFAM PRC-barrel domain
JW646_14110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JW646_14120	COG0745	RESPONSE REGULATOR receiver
JW646_14125	COG5002	protein histidine kinase activity
JW646_14150	COG1160	GTP binding
JW646_14155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JW646_14160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JW646_14165	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JW646_14170	COG1115	amino acid carrier protein
JW646_14190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JW646_14195	COG1799	cell septum assembly
JW646_14210	COG3599	regulation of cell shape
JW646_14215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JW646_14230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JW646_14240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JW646_14250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JW646_14255	COG0564	pseudouridine synthase activity
JW646_14260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JW646_14275	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JW646_14285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JW646_14290	COG1561	YicC-like family, N-terminal region
JW646_14295	COG0194	GDP metabolic process
JW646_14300	COG1758	RNA polymerase activity
JW646_14305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JW646_14310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JW646_14315	COG0242	peptide deformylase activity
JW646_14320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JW646_14330	COG2738	Putative neutral zinc metallopeptidase
JW646_14335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JW646_14335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JW646_14340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JW646_14345	COG0631	protein serine/threonine phosphatase activity
JW646_14350	COG0515	serine threonine protein kinase
JW646_14350	COG2815	serine threonine protein kinase
JW646_14355	COG1162	GTPase activity
JW646_14360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JW646_14370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JW646_14380	COG1461	Dihydroxyacetone kinase
JW646_14385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JW646_14390	COG0742	ribosomal rna small subunit methyltransferase
JW646_14395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JW646_14405	COG3314	Sporulation integral membrane protein YlbJ
JW646_14410	COG1323	Belongs to the UPF0348 family
JW646_14415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JW646_14425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JW646_14430	COG0416	fatty acid biosynthetic process
JW646_14435	COG3022	response to hydroperoxide
JW646_14445	COG3854	ATPases associated with a variety of cellular activities
JW646_14485	COG1302	Protein conserved in bacteria
JW646_14490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JW646_14495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JW646_14500	COG1570	exodeoxyribonuclease VII activity
JW646_14505	COG1722	exodeoxyribonuclease VII activity
JW646_14510	COG0142	geranyltranstransferase activity
JW646_14515	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
JW646_14520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JW646_14525	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
JW646_14530	COG0497	DNA recombination
JW646_14560	COG1215	transferase activity, transferring glycosyl groups
JW646_14585	COG4974	Belongs to the 'phage' integrase family
JW646_14590	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JW646_14600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JW646_14605	COG4122	O-methyltransferase activity
JW646_14610	COG0826	peptidase U32
JW646_14615	COG1846	Transcriptional regulator
JW646_14630	COG2205	protein histidine kinase activity
JW646_14635	COG5002	protein histidine kinase activity
JW646_14640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JW646_14670	COG0583	DNA-binding transcription factor activity
JW646_14685	COG1301	dicarboxylic acid transport
JW646_14690	COG0583	DNA-binding transcription factor activity
JW646_14710	COG0738	Major facilitator superfamily
JW646_14720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JW646_14725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JW646_14735	COG0571	ribonuclease III activity
JW646_14750	COG0552	protein localization to endoplasmic reticulum
JW646_14755	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JW646_14760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JW646_14765	COG0228	four-way junction DNA binding
JW646_14775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JW646_14780	COG0336	Belongs to the RNA methyltransferase TrmD family
JW646_14785	COG0335	large ribosomal subunit rRNA binding
JW646_14800	COG1757	Na H antiporter
JW646_14805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JW646_14820	COG0583	DNA-binding transcription factor activity
JW646_14835	COG0513	Belongs to the DEAD box helicase family
JW646_14840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JW646_14840	COG0392	lysyltransferase activity
JW646_14855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JW646_14870	COG1216	Glycosyl transferase, family 2
JW646_14870	COG1442	glycosyl transferase family 8
JW646_14885	COG1131	(ABC) transporter
JW646_14900	COG1078	dGTPase activity
JW646_14905	COG0768	penicillin binding
JW646_14915	COG2239	Acts as a magnesium transporter
JW646_14920	COG0745	RESPONSE REGULATOR receiver
JW646_14925	COG5002	protein histidine kinase activity
JW646_14925	COG3850	Histidine kinase
JW646_14930	COG0577	efflux transmembrane transporter activity
JW646_14930	COG1136	(ABC) transporter
JW646_14935	COG1136	(ABC) transporter
JW646_14935	COG0577	efflux transmembrane transporter activity
JW646_14945	COG2843	Capsule synthesis protein
JW646_14955	COG2843	Capsule synthesis protein
JW646_14960	COG0792	nuclease activity
JW646_14965	COG0606	chelatase, subunit chli
JW646_14970	COG0758	DNA mediated transformation
JW646_14975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JW646_14985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JW646_15000	COG1959	2 iron, 2 sulfur cluster binding
JW646_15010	COG0822	iron-sulfur transferase activity
JW646_15015	COG0482	sulfurtransferase activity
JW646_15020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JW646_15025	COG4472	Bacterial protein of unknown function (DUF965)
JW646_15040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JW646_15045	COG3906	Belongs to the UPF0473 family
JW646_15050	COG1316	TRANSCRIPTIONal
JW646_15055	COG0735	belongs to the Fur family
JW646_15060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JW646_15065	COG3679	Belongs to the UPF0342 family
JW646_15070	COG1550	Protein conserved in bacteria
JW646_15075	COG1686	Belongs to the peptidase S11 family
JW646_15080	COG1994	Peptidase M50
JW646_15085	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JW646_15090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JW646_15105	COG3874	Sporulation protein YtfJ
JW646_15135	COG0779	Required for maturation of 30S ribosomal subunits
JW646_15140	COG0195	Participates in both transcription termination and antitermination
JW646_15145	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JW646_15155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JW646_15165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JW646_15170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JW646_15175	COG0196	riboflavin kinase activity
JW646_15180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JW646_15185	COG1307	EDD domain protein, DegV family
JW646_15190	COG1185	polyribonucleotide nucleotidyltransferase activity
JW646_15200	COG0612	Peptidase, M16
JW646_15205	COG1873	PFAM PRC-barrel domain
JW646_15210	COG0527	aspartate kinase activity
JW646_15215	COG0740	serine-type endopeptidase activity
JW646_15225	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
JW646_15230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JW646_15235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JW646_15240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JW646_15245	COG1418	mRNA catabolic process
JW646_15255	COG0582	viral genome integration into host DNA
JW646_15270	COG0436	Aminotransferase
JW646_15280	COG0708	Exodeoxyribonuclease III
JW646_15295	COG0739	heme binding
JW646_15305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JW646_15360	COG1278	Cold shock
JW646_15385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JW646_15415	COG2340	Cysteine-rich secretory protein family
JW646_15425	COG2032	superoxide dismutase activity
JW646_15440	COG3326	Membrane
JW646_15445	COG1278	Cold shock
JW646_15455	COG3273	potassium ion transport
JW646_15455	COG0471	metal ion transport
JW646_15475	COG1619	proteins homologs of microcin C7 resistance protein MccF
JW646_15490	COG0584	glycerophosphoryl diester phosphodiesterase
JW646_15495	COG0488	(ABC) transporter
JW646_15510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JW646_15520	COG0840	transmembrane signaling receptor activity
JW646_15520	COG3290	protein histidine kinase activity
JW646_15535	COG1404	Belongs to the peptidase S8 family
JW646_15535	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JW646_15555	COG0456	acetyltransferase
JW646_15575	COG0662	Cupin 2, conserved barrel domain protein
JW646_15585	COG1253	flavin adenine dinucleotide binding
JW646_15590	COG1253	flavin adenine dinucleotide binding
JW646_15600	COG0154	amidase activity
JW646_15605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JW646_15615	COG3708	Transcriptional regulator
JW646_15615	COG2207	Transcriptional regulator
JW646_15640	COG0515	serine threonine protein kinase
JW646_15655	COG2133	pyrroloquinoline quinone binding
JW646_15690	COG3595	metallopeptidase activity
JW646_15765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JW646_15805	COG0488	(ABC) transporter
JW646_15825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JW646_15830	COG1263	PTS System
JW646_15830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW646_15840	COG1486	melibiose metabolic process
JW646_15845	COG1263	PTS System
JW646_15845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JW646_15845	COG2190	(PTS) system
JW646_15850	COG1737	Transcriptional regulator
JW646_15865	COG2199	diguanylate cyclase activity
JW646_15875	COG1428	Deoxynucleoside kinase
JW646_15880	COG1428	Deoxynucleoside kinase
JW646_15885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JW646_15895	COG1773	rubredoxin
JW646_15895	COG1592	Rubrerythrin
JW646_15905	COG1592	Rubrerythrin
JW646_15905	COG1773	rubredoxin
JW646_15910	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JW646_15915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JW646_15920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JW646_15925	COG1605	Chorismate mutase
JW646_15925	COG0077	Prephenate dehydratase
JW646_15940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JW646_15955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JW646_15975	COG0737	Belongs to the 5'-nucleotidase family
JW646_15985	COG0745	RESPONSE REGULATOR receiver
JW646_15990	COG2205	protein histidine kinase activity
JW646_15995	COG1136	(ABC) transporter
JW646_16000	COG0577	efflux transmembrane transporter activity
JW646_16005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JW646_16030	COG5012	cobalamin binding
JW646_16035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JW646_16050	COG1511	domain protein
JW646_16095	COG1288	antiporter activity
JW646_16100	COG2195	Cleaves the N-terminal amino acid of tripeptides
JW646_16105	COG1725	Transcriptional regulator
JW646_16110	COG1131	(ABC) transporter
JW646_16125	COG0745	RESPONSE REGULATOR receiver
JW646_16130	COG5002	protein histidine kinase activity
JW646_16135	COG1136	(ABC) transporter
JW646_16135	COG0577	efflux transmembrane transporter activity
JW646_16145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JW646_16160	COG0242	peptide deformylase activity
JW646_16180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JW646_16205	COG0003	Pfam Anion-transporting ATPase
JW646_16215	COG0003	Pfam Anion-transporting ATPase
JW646_16240	COG1131	(ABC) transporter
JW646_16245	COG3104	oligopeptide transport
JW646_16250	COG2197	response regulator
JW646_16255	COG4585	Histidine kinase
JW646_16260	COG1131	(ABC) transporter
JW646_16275	COG0512	Glutamine amidotransferase of anthranilate synthase
JW646_16280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JW646_16285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JW646_16290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JW646_16290	COG1605	Chorismate mutase
JW646_16310	COG0840	transmembrane signaling receptor activity
JW646_16355	COG0488	(ABC) transporter
JW646_16360	COG1309	transcriptional regulator
JW646_16395	COG1132	(ABC) transporter
JW646_16400	COG1132	(ABC) transporter
JW646_16410	COG1278	Cold shock
JW646_16415	COG3257	ureidoglycine aminohydrolase activity
JW646_16420	COG1388	LysM domain
JW646_16420	COG3584	3D domain protein
JW646_16540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JW646_16590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JW646_16605	COG0673	inositol 2-dehydrogenase activity
JW646_16610	COG0583	DNA-binding transcription factor activity
JW646_16615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JW646_16625	COG2897	thiosulfate sulfurtransferase activity
JW646_16645	COG1484	DNA-dependent DNA replication
JW646_16765	COG1012	belongs to the aldehyde dehydrogenase family
JW646_16815	COG2205	protein histidine kinase activity
JW646_16830	COG2153	protein acetylation
JW646_16845	COG0628	permease
JW646_16905	COG0006	proline dipeptidase activity
JW646_16970	COG0728	peptidoglycan biosynthetic process
JW646_17020	COG3457	Alanine racemase
JW646_17025	COG3314	Sporulation integral membrane protein YlbJ
JW646_17030	COG0515	serine threonine protein kinase
JW646_17030	COG2815	serine threonine protein kinase
JW646_17040	COG0745	RESPONSE REGULATOR receiver
JW646_17050	COG1132	(ABC) transporter
JW646_17065	COG2720	vancomycin resistance protein
JW646_17070	COG1773	rubredoxin
JW646_17070	COG1592	Rubrerythrin
JW646_17105	COG1396	sequence-specific DNA binding
JW646_17135	COG1484	DNA-dependent DNA replication
JW646_17150	COG0629	single-stranded DNA binding
JW646_17195	COG0582	viral genome integration into host DNA
JW646_17275	COG1652	LysM domain
JW646_17360	COG0124	histidyl-tRNA synthetase
JW646_17365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JW646_17370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JW646_17375	COG0131	Imidazoleglycerol-phosphate dehydratase
JW646_17380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JW646_17385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JW646_17390	COG0107	imidazoleglycerol-phosphate synthase activity
JW646_17395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JW646_17395	COG0140	phosphoribosyl-ATP diphosphatase activity
JW646_17410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JW646_17420	COG0697	spore germination
JW646_17425	COG0733	neurotransmitter:sodium symporter activity
JW646_17430	COG0393	Putative heavy-metal-binding
JW646_17455	COG1283	sodium-dependent phosphate transmembrane transporter activity
JW646_17475	COG0786	glutamate:sodium symporter activity
JW646_17495	COG2207	Transcriptional regulator
JW646_17505	COG2376	Dihydroxyacetone kinase
JW646_17520	COG1131	(ABC) transporter
JW646_17550	COG0488	(ABC) transporter
JW646_17580	COG4988	ABC transporter
JW646_17585	COG1132	(ABC) transporter
JW646_17600	COG0215	cysteine-tRNA ligase activity
JW646_17610	COG0803	Belongs to the bacterial solute-binding protein 9 family
JW646_17610	COG3443	Belongs to the bacterial solute-binding protein 9 family
JW646_17615	COG1121	(ABC) transporter
JW646_17620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JW646_17635	COG0745	RESPONSE REGULATOR receiver
JW646_17640	COG5002	protein histidine kinase activity
JW646_17645	COG3118	belongs to the thioredoxin family
JW646_17650	COG0492	ferredoxin-NADP+ reductase activity
JW646_17675	COG0514	ATP-dependent DNA helicase (RecQ)
JW646_17700	COG1122	ATPase activity
JW646_17705	COG0494	nUDIX hydrolase
JW646_17715	COG1141	Ferredoxin
JW646_17725	COG0351	phosphomethylpyrimidine kinase
JW646_17730	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JW646_17735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JW646_17745	COG0352	thiamine-phosphate diphosphorylase activity
JW646_17750	COG1309	transcriptional regulator
JW646_17765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JW646_17770	COG2333	competence protein COMEC
JW646_17770	COG0658	competence protein
JW646_17810	COG1217	gtp-binding protein TYPA
JW646_17820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JW646_17825	COG0745	RESPONSE REGULATOR receiver
JW646_17830	COG5002	protein histidine kinase activity
JW646_17850	COG2252	PERMEase
JW646_17855	COG0534	Mate efflux family protein
JW646_17860	COG0826	peptidase U32
JW646_17865	COG0024	Methionine aminopeptidase
JW646_17880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JW646_17885	COG4708	membrane
JW646_17895	COG0488	(ABC) transporter
JW646_17915	COG0129	dihydroxy-acid dehydratase activity
JW646_17920	COG1378	Sugar-specific transcriptional regulator TrmB
JW646_17930	COG1278	Cold shock
JW646_17945	COG4948	Mandelate Racemase Muconate Lactonizing
JW646_17955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JW646_18005	COG1597	lipid kinase activity
JW646_18010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JW646_18035	COG0019	diaminopimelate decarboxylase activity
JW646_18045	COG1187	pseudouridine synthase activity
JW646_18050	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JW646_18055	COG1737	Transcriptional regulator
JW646_18060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JW646_18065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JW646_18070	COG0473	3-isopropylmalate dehydrogenase activity
JW646_18075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JW646_18090	COG1028	Short-chain dehydrogenase reductase Sdr
JW646_18100	COG0446	pyridine nucleotide-disulphide oxidoreductase
JW646_18115	COG0785	Cytochrome C biogenesis protein
JW646_18130	COG4294	response to UV
JW646_18140	COG2323	membrane
JW646_18150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JW646_18155	COG0494	nUDIX hydrolase
JW646_18165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JW646_18170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JW646_18175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JW646_18180	COG1923	regulation of RNA biosynthetic process
JW646_18185	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JW646_18235	COG1396	sequence-specific DNA binding
JW646_18255	COG3645	SOS response
JW646_18255	COG3646	Phage regulatory protein
JW646_18425	COG5484	DNA packaging
JW646_18425	COG3728	DNA packaging
JW646_18550	COG4824	toxin secretion phage lysis holin
JW646_18605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JW646_18610	COG1316	TRANSCRIPTIONal
JW646_18615	COG1316	TRANSCRIPTIONal
JW646_18620	COG1744	ABC transporter substrate-binding protein PnrA-like
JW646_18625	COG3845	ABC transporter
JW646_18630	COG4603	Belongs to the binding-protein-dependent transport system permease family
JW646_18635	COG1079	Belongs to the binding-protein-dependent transport system permease family
JW646_18640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JW646_18645	COG1116	anion transmembrane transporter activity
JW646_18665	COG1073	alpha beta
JW646_18670	COG1216	Glycosyl transferase, family 2
JW646_18670	COG1442	glycosyl transferase family 8
JW646_18680	COG0813	purine-nucleoside phosphorylase activity
JW646_18685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JW646_18690	COG4974	Belongs to the 'phage' integrase family
JW646_18695	COG2359	stage V sporulation protein S
JW646_18720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JW646_18730	COG0582	viral genome integration into host DNA
JW646_18740	COG3104	oligopeptide transport
JW646_18795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JW646_18800	COG0204	Acyl-transferase
JW646_18805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JW646_18810	COG2081	HI0933 family
JW646_18820	COG3973	AAA domain
JW646_18870	COG1744	ABC transporter substrate-binding protein PnrA-like
JW646_18875	COG0475	glutathione-regulated potassium exporter activity
JW646_18880	COG0137	argininosuccinate synthase activity
JW646_18895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JW646_18905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JW646_18915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JW646_18945	COG5002	protein histidine kinase activity
JW646_18965	COG0758	DNA mediated transformation
JW646_18975	COG1752	Esterase of the alpha-beta hydrolase superfamily
JW646_19000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JW646_19020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JW646_19025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JW646_19035	COG1696	Membrane protein involved in D-alanine export
JW646_19060	COG4608	Belongs to the ABC transporter superfamily
JW646_19065	COG0444	Belongs to the ABC transporter superfamily
JW646_19070	COG0747	negative chemotaxis
JW646_19075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JW646_19080	COG0601	transmembrane transport
JW646_19090	COG0322	excinuclease ABC activity
JW646_19105	COG5564	TIM-barrel signal transduction protein
JW646_19115	COG5564	TIM-barrel signal transduction protein
JW646_19120	COG5002	protein histidine kinase activity
JW646_19145	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JW646_19155	COG1151	hydroxylamine reductase activity
JW646_19160	COG0583	DNA-binding transcription factor activity
JW646_19305	COG0798	PFAM Bile acid sodium symporter
JW646_19325	COG0640	Transcriptional regulator
JW646_19330	COG0701	Predicted permease
JW646_19345	COG3404	Formiminotransferase-cyclodeaminase
JW646_19380	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JW646_19390	COG1846	Transcriptional regulator
JW646_19395	COG0346	lactoylglutathione lyase activity
JW646_19400	COG3546	catalase activity
JW646_19410	COG1819	glycosyl
JW646_19420	COG0531	amino acid
JW646_19455	COG1301	dicarboxylic acid transport
JW646_19465	COG1404	Belongs to the peptidase S8 family
JW646_19470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JW646_19485	COG0443	Heat shock 70 kDa protein
JW646_19490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JW646_19495	COG0484	heat shock protein binding
JW646_19520	COG0860	N-Acetylmuramoyl-L-alanine amidase
JW646_19530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JW646_19535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JW646_19540	COG0384	phenazine biosynthesis protein PhzF
JW646_19545	COG0589	response to stress
JW646_19545	COG0475	glutathione-regulated potassium exporter activity
JW646_19550	COG1668	transmembrane transport
JW646_19555	COG4152	abc transporter atp-binding protein
JW646_19560	COG0596	Alpha beta hydrolase
JW646_19585	COG1136	(ABC) transporter
JW646_19590	COG2205	protein histidine kinase activity
JW646_19595	COG0745	RESPONSE REGULATOR receiver
JW646_19610	COG1131	(ABC) transporter
JW646_19615	COG1725	Transcriptional regulator
JW646_19630	COG2226	methyltransferase
JW646_19635	COG0464	growth
JW646_19650	COG1253	flavin adenine dinucleotide binding
JW646_19655	COG1362	aminopeptidase activity
JW646_19660	COG1115	amino acid carrier protein
JW646_19680	COG0129	dihydroxy-acid dehydratase activity
JW646_19705	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
JW646_19710	COG1522	sequence-specific DNA binding
JW646_19710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JW646_19730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JW646_19755	COG2155	Conserved Protein
JW646_19760	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
JW646_19780	COG1132	(ABC) transporter
JW646_19785	COG1132	(ABC) transporter
JW646_19795	COG0243	molybdopterin cofactor binding
JW646_19805	COG0346	lactoylglutathione lyase activity
JW646_19815	COG1695	Transcriptional regulator
JW646_19825	COG3976	FMN-binding domain protein
JW646_19825	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
JW646_19830	COG0406	alpha-ribazole phosphatase activity
JW646_19835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JW646_19840	COG3875	lactate racemase activity
JW646_19845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JW646_19875	COG0546	phosphoglycolate phosphatase activity
JW646_19890	COG1733	regulation of RNA biosynthetic process
JW646_19905	COG0312	modulator of DNA gyrase
JW646_19910	COG0312	modulator of DNA gyrase
JW646_19935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JW646_19945	COG1686	Belongs to the peptidase S11 family
JW646_19975	COG0659	secondary active sulfate transmembrane transporter activity
JW646_19980	COG1454	alcohol dehydrogenase
JW646_20000	COG0252	asparaginase activity
JW646_20000	COG5275	peptidyl-tyrosine sulfation
JW646_20015	COG1104	cysteine desulfurase activity
JW646_20020	COG0583	DNA-binding transcription factor activity
JW646_20050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JW646_20055	COG1278	Cold shock
JW646_20080	COG0252	asparaginase activity
JW646_20080	COG5275	peptidyl-tyrosine sulfation