locus-tag	class	description
H9L22_00055	COG4209	transmembrane transport
H9L22_00060	COG0395	ABC-type sugar transport system, permease component
H9L22_00070	COG1501	Belongs to the glycosyl hydrolase 31 family
H9L22_00075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9L22_00095	COG0406	alpha-ribazole phosphatase activity
H9L22_00095	COG0494	nUDIX hydrolase
H9L22_00100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9L22_00105	COG0456	acetyltransferase
H9L22_00110	COG0745	RESPONSE REGULATOR receiver
H9L22_00120	COG1490	D-aminoacyl-tRNA deacylase activity
H9L22_00125	COG3485	protocatechuate 3,4-dioxygenase
H9L22_00175	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L22_00200	COG2826	transposase and inactivated derivatives, IS30 family
H9L22_00255	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L22_00260	COG1217	gtp-binding protein TYPA
H9L22_00275	COG3534	alpha-L-arabinofuranosidase
H9L22_00305	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L22_00325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9L22_00325	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H9L22_00325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L22_00330	COG1461	Dihydroxyacetone kinase
H9L22_00335	COG2376	Dihydroxyacetone kinase
H9L22_00340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9L22_00355	COG0151	Belongs to the GarS family
H9L22_00405	COG1028	Short-chain dehydrogenase reductase Sdr
H9L22_00420	COG3387	PFAM Glycoside hydrolase 15-related
H9L22_00430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9L22_00445	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H9L22_00450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H9L22_00455	COG0765	amino acid transport
H9L22_00460	COG0765	amino acid transport
H9L22_00465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L22_00470	COG1126	abc transporter atp-binding protein
H9L22_00515	COG1175	transmembrane transport
H9L22_00520	COG0395	ABC-type sugar transport system, permease component
H9L22_00540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9L22_00550	COG2094	Belongs to the DNA glycosylase MPG family
H9L22_00565	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L22_00570	COG0047	phosphoribosylformylglycinamidine synthase activity
H9L22_00590	COG1404	Belongs to the peptidase S8 family
H9L22_00595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L22_00610	COG0175	sulfate reduction
H9L22_00615	COG1218	3'(2'),5'-bisphosphate nucleotidase
H9L22_00620	COG0529	Catalyzes the synthesis of activated sulfate
H9L22_00710	COG0366	Alpha amylase catalytic
H9L22_00715	COG1609	Transcriptional regulator
H9L22_00720	COG2182	Extracellular solute-binding protein
H9L22_00730	COG3833	ABC-type maltose transport systems, permease component
H9L22_00750	COG0746	molybdenum cofactor guanylyltransferase activity
H9L22_00760	COG1140	nitrate reductase beta subunit
H9L22_00785	COG0314	molybdopterin synthase activity
H9L22_00800	COG0315	cyclic pyranopterin monophosphate synthase activity
H9L22_00805	COG0315	cyclic pyranopterin monophosphate synthase activity
H9L22_00805	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9L22_00855	COG0745	RESPONSE REGULATOR receiver
H9L22_00860	COG0642	Histidine kinase
H9L22_00905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9L22_00935	COG2801	Transposase and inactivated derivatives
H9L22_00940	COG3005	denitrification pathway
H9L22_00985	COG0366	Alpha amylase catalytic
H9L22_01010	COG0459	protein refolding
H9L22_01045	COG3226	Transcriptional regulator
H9L22_01095	COG3119	arylsulfatase activity
H9L22_01115	COG4209	transmembrane transport
H9L22_01130	COG5434	Belongs to the glycosyl hydrolase 28 family
H9L22_01145	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H9L22_01150	COG0673	inositol 2-dehydrogenase activity
H9L22_01155	COG3547	Transposase (IS116 IS110 IS902 family)
H9L22_01170	COG1609	Transcriptional regulator
H9L22_01185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H9L22_01210	COG1461	Dihydroxyacetone kinase
H9L22_01225	COG1609	Transcriptional regulator
H9L22_01230	COG0395	ABC-type sugar transport system, permease component
H9L22_01235	COG1175	transmembrane transport
H9L22_01250	COG4948	Mandelate Racemase Muconate Lactonizing
H9L22_01255	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H9L22_01260	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H9L22_01270	COG2226	methyltransferase
H9L22_01275	COG4133	protoheme IX ABC transporter activity
H9L22_01285	COG1169	isochorismate synthase
H9L22_01300	COG0644	oxidoreductase
H9L22_01320	COG0649	NAD binding
H9L22_01340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H9L22_01345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L22_01370	COG1007	ATP synthesis coupled electron transport
H9L22_01375	COG0142	geranyltranstransferase activity
H9L22_01400	COG1013	pyruvate-flavodoxin oxidoreductase activity
H9L22_01405	COG0674	pyruvate-flavodoxin oxidoreductase activity
H9L22_01405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H9L22_01410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9L22_01415	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L22_01425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L22_01440	COG1666	GTP binding
H9L22_01450	COG0813	purine-nucleoside phosphorylase activity
H9L22_01465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L22_01470	COG2030	dehydratase
H9L22_01480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9L22_01485	COG1473	amidohydrolase
H9L22_01490	COG1132	(ABC) transporter
H9L22_01495	COG1132	(ABC) transporter
H9L22_01500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9L22_01510	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9L22_01515	COG0250	Participates in transcription elongation, termination and antitermination
H9L22_01520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9L22_01525	COG0081	regulation of translation
H9L22_01530	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H9L22_01535	COG1024	Enoyl-CoA hydratase
H9L22_01545	COG0395	ABC-type sugar transport system, permease component
H9L22_01565	COG4974	Belongs to the 'phage' integrase family
H9L22_01575	COG0582	viral genome integration into host DNA
H9L22_01600	COG1126	abc transporter atp-binding protein
H9L22_01605	COG0765	amino acid transport
H9L22_01610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L22_01615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9L22_01620	COG0222	ribosome binding
H9L22_01625	COG0085	RNA polymerase activity
H9L22_01630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9L22_01635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9L22_01640	COG0049	tRNA binding
H9L22_01670	COG2059	Chromate
H9L22_01680	COG1940	carbohydrate kinase activity
H9L22_01705	COG1175	transmembrane transport
H9L22_01710	COG0395	ABC-type sugar transport system, permease component
H9L22_01755	COG0435	Glutathione S-transferase
H9L22_01760	COG1132	(ABC) transporter
H9L22_01790	COG0494	nUDIX hydrolase
H9L22_01805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9L22_01810	COG0051	transcription antitermination factor activity, RNA binding
H9L22_01820	COG0088	Forms part of the polypeptide exit tunnel
H9L22_01825	COG0089	rRNA binding
H9L22_01830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9L22_01835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9L22_01840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9L22_01845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9L22_01850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9L22_01855	COG0255	Belongs to the universal ribosomal protein uL29 family
H9L22_01860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9L22_01865	COG1609	Transcriptional regulator
H9L22_01870	COG0366	Alpha amylase catalytic
H9L22_01875	COG1653	transport
H9L22_01890	COG1950	PFAM Membrane protein of
H9L22_01900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9L22_01905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9L22_01910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9L22_01915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9L22_01920	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9L22_01930	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9L22_01935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9L22_01940	COG1841	ribosomal large subunit assembly
H9L22_01945	COG0200	Binds to the 23S rRNA
H9L22_01955	COG0563	adenylate kinase activity
H9L22_01960	COG0024	Methionine aminopeptidase
H9L22_01990	COG0395	ABC-type sugar transport system, permease component
H9L22_02005	COG1609	Transcriptional regulator
H9L22_02015	COG3459	Glycosyltransferase 36 associated
H9L22_02025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9L22_02030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9L22_02035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9L22_02040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9L22_02045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9L22_02050	COG0202	RNA polymerase activity
H9L22_02055	COG0203	ribosomal protein L17
H9L22_02070	COG4120	Belongs to the binding-protein-dependent transport system permease family
H9L22_02075	COG3842	ATPase activity
H9L22_02090	COG2755	lipolytic protein G-D-S-L family
H9L22_02090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9L22_02100	COG2813	Specifically methylates the guanine in position
H9L22_02105	COG0101	tRNA pseudouridine synthase activity
H9L22_02110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9L22_02115	COG3304	Inner membrane component domain
H9L22_02135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9L22_02140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9L22_02155	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H9L22_02195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9L22_02240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H9L22_02250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9L22_02255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9L22_02265	COG0604	alcohol dehydrogenase
H9L22_02290	COG1823	symporter activity
H9L22_02310	COG0656	L-ascorbic acid biosynthetic process
H9L22_02315	COG0246	Mannitol dehydrogenase
H9L22_02320	COG1904	glucuronate isomerase
H9L22_02325	COG1609	Transcriptional regulator
H9L22_02350	COG2211	Major facilitator Superfamily
H9L22_02375	COG0488	(ABC) transporter
H9L22_02385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9L22_02390	COG0321	lipoyl(octanoyl) transferase activity
H9L22_02400	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L22_02405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L22_02415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9L22_02455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9L22_02475	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H9L22_02480	COG0723	plastoquinol--plastocyanin reductase activity
H9L22_02490	COG1845	cytochrome c oxidase, subunit III
H9L22_02505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9L22_02515	COG3214	Protein conserved in bacteria
H9L22_02520	COG0088	Forms part of the polypeptide exit tunnel
H9L22_02525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L22_02550	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
H9L22_02560	COG4303	Ethanolamine ammonia lyase large subunit
H9L22_02565	COG4302	ethanolamine ammonia-lyase activity
H9L22_02575	COG1454	alcohol dehydrogenase
H9L22_02575	COG1012	belongs to the aldehyde dehydrogenase family
H9L22_02585	COG4766	ethanolamine catabolic process
H9L22_02600	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H9L22_02630	COG4585	Histidine kinase
H9L22_02635	COG2197	response regulator
H9L22_02640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H9L22_02670	COG3250	beta-galactosidase activity
H9L22_02675	COG2815	serine threonine protein kinase
H9L22_02675	COG0515	serine threonine protein kinase
H9L22_02680	COG0352	thiamine-phosphate diphosphorylase activity
H9L22_02725	COG3773	Cell wall hydrolase
H9L22_02725	COG3409	Peptidoglycan-binding domain 1 protein
H9L22_02740	COG0406	alpha-ribazole phosphatase activity
H9L22_02745	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H9L22_02750	COG1492	cobalamin metabolic process
H9L22_02770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9L22_02770	COG1648	precorrin-2 dehydrogenase activity
H9L22_02780	COG0310	cobalt ion transport
H9L22_02815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9L22_02815	COG1648	precorrin-2 dehydrogenase activity
H9L22_02820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9L22_02820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L22_02825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L22_02830	COG0535	radical SAM domain protein
H9L22_02840	COG3253	May function as heme-dependent peroxidase
H9L22_02840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9L22_02845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9L22_02850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9L22_02860	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H9L22_02870	COG0181	hydroxymethylbilane synthase activity
H9L22_02875	COG0113	porphobilinogen synthase activity
H9L22_02880	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9L22_02895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L22_02965	COG1191	sigma factor activity
H9L22_02990	COG1643	Atp-dependent helicase
H9L22_02995	COG0395	ABC-type sugar transport system, permease component
H9L22_03020	COG1131	(ABC) transporter
H9L22_03035	COG0556	nucleotide-excision repair
H9L22_03055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9L22_03065	COG2066	Belongs to the glutaminase family
H9L22_03080	COG0395	ABC-type sugar transport system, permease component
H9L22_03085	COG1175	transmembrane transport
H9L22_03090	COG1653	transport
H9L22_03095	COG0322	excinuclease ABC activity
H9L22_03100	COG1268	BioY protein
H9L22_03105	COG1122	ATPase activity
H9L22_03115	COG1660	Displays ATPase and GTPase activities
H9L22_03125	COG1481	regulation of sporulation
H9L22_03130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9L22_03135	COG0126	phosphoglycerate kinase activity
H9L22_03140	COG0149	triose-phosphate isomerase activity
H9L22_03145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9L22_03155	COG0363	glucosamine-6-phosphate deaminase activity
H9L22_03180	COG2814	Major facilitator Superfamily
H9L22_03195	COG4585	Histidine kinase
H9L22_03225	COG1131	(ABC) transporter
H9L22_03250	COG0396	ATPase activity
H9L22_03255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9L22_03260	COG0822	iron-sulfur transferase activity
H9L22_03270	COG1063	alcohol dehydrogenase
H9L22_03280	COG1609	Transcriptional regulator
H9L22_03285	COG1609	Transcriptional regulator
H9L22_03335	COG3328	transposase activity
H9L22_03345	COG1484	DNA-dependent DNA replication
H9L22_03365	COG4974	Belongs to the 'phage' integrase family
H9L22_03375	COG0582	viral genome integration into host DNA
H9L22_03405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H9L22_03425	COG2197	response regulator
H9L22_03435	COG0488	(ABC) transporter
H9L22_03440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L22_03445	COG0366	Alpha amylase catalytic
H9L22_03450	COG2211	Major facilitator Superfamily
H9L22_03450	COG2190	(PTS) system
H9L22_03455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9L22_03475	COG1028	Short-chain dehydrogenase reductase Sdr
H9L22_03505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9L22_03510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L22_03520	COG0242	peptide deformylase activity
H9L22_03525	COG4974	Belongs to the 'phage' integrase family
H9L22_03535	COG0052	Belongs to the universal ribosomal protein uS2 family
H9L22_03540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9L22_03550	COG0233	cytoplasmic translational termination
H9L22_03555	COG0575	Belongs to the CDS family
H9L22_03560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9L22_03565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H9L22_03575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9L22_03580	COG0750	zinc metalloprotease
H9L22_03585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9L22_03595	COG0442	prolyl-tRNA aminoacylation
H9L22_03620	COG0779	Required for maturation of 30S ribosomal subunits
H9L22_03625	COG0195	Participates in both transcription termination and antitermination
H9L22_03645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9L22_03650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9L22_03670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9L22_03690	COG1185	polyribonucleotide nucleotidyltransferase activity
H9L22_03695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9L22_03705	COG0456	acetyltransferase
H9L22_03715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9L22_03720	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9L22_03725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9L22_03730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9L22_03750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9L22_03755	COG0799	negative regulation of ribosome biogenesis
H9L22_03760	COG0406	alpha-ribazole phosphatase activity
H9L22_03770	COG0181	hydroxymethylbilane synthase activity
H9L22_03845	COG1414	Transcriptional regulator
H9L22_03850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9L22_03855	COG0066	3-isopropylmalate dehydratase activity
H9L22_03865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H9L22_03895	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9L22_03905	COG1505	serine-type exopeptidase activity
H9L22_03920	COG0204	Acyl-transferase
H9L22_03925	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L22_03935	COG1674	ftsk spoiiie
H9L22_03940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L22_03950	COG1546	Belongs to the CinA family
H9L22_03950	COG1058	Belongs to the CinA family
H9L22_03955	COG1396	sequence-specific DNA binding
H9L22_03975	COG2137	regulation of response to DNA damage stimulus
H9L22_03980	COG1418	mRNA catabolic process
H9L22_03985	COG2017	converts alpha-aldose to the beta-anomer
H9L22_04000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9L22_04005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9L22_04010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9L22_04020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9L22_04030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9L22_04065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L22_04105	COG1946	Acyl-CoA thioesterase
H9L22_04115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L22_04200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9L22_04200	COG0519	Catalyzes the synthesis of GMP from XMP
H9L22_04205	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H9L22_04220	COG1074	ATP-dependent DNA helicase activity
H9L22_04365	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H9L22_04415	COG0517	IMP dehydrogenase activity
H9L22_04420	COG0747	negative chemotaxis
H9L22_04430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L22_04445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9L22_04475	COG1595	DNA-templated transcription, initiation
H9L22_04500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9L22_04510	COG0567	Dehydrogenase, E1 component
H9L22_04510	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L22_04535	COG0019	diaminopimelate decarboxylase activity
H9L22_04545	COG0083	homoserine kinase activity
H9L22_04555	COG0254	rRNA binding
H9L22_04560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9L22_04565	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L22_04570	COG0009	L-threonylcarbamoyladenylate synthase
H9L22_04575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L22_04590	COG0356	it plays a direct role in the translocation of protons across the membrane
H9L22_04600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9L22_04605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L22_04610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9L22_04615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9L22_04620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9L22_04625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9L22_04640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L22_04700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H9L22_04705	COG3281	Trehalose synthase
H9L22_04725	COG0482	sulfurtransferase activity
H9L22_04745	COG0154	amidase activity
H9L22_04750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L22_04755	COG3177	Filamentation induced by cAMP protein fic
H9L22_04770	COG2258	MOSC domain
H9L22_04775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9L22_04795	COG0134	indole-3-glycerol-phosphate synthase activity
H9L22_04800	COG0133	tryptophan synthase activity
H9L22_04820	COG0457	Tetratricopeptide repeat
H9L22_04845	COG0698	ribose 5-phosphate isomerase
H9L22_04850	COG1940	carbohydrate kinase activity
H9L22_04875	COG0587	DNA-directed DNA polymerase activity
H9L22_04885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H9L22_04895	COG0131	Imidazoleglycerol-phosphate dehydratase
H9L22_04900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H9L22_04905	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9L22_04935	COG0217	transcriptional regulatory protein
H9L22_04940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9L22_04945	COG0632	four-way junction helicase activity
H9L22_04955	COG1862	Preprotein translocase
H9L22_04960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9L22_04965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9L22_04970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L22_04980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9L22_04985	COG1196	nuclear chromosome segregation
H9L22_04990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L22_05000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9L22_05005	COG2814	Major facilitator Superfamily
H9L22_05025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9L22_05030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9L22_05040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9L22_05050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9L22_05055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9L22_05060	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H9L22_05075	COG1132	(ABC) transporter
H9L22_05155	COG0647	UMP catabolic process
H9L22_05165	COG4115	mRNA cleavage
H9L22_05205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9L22_05210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L22_05215	COG0505	Belongs to the CarA family
H9L22_05220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9L22_05225	COG0167	dihydroorotate dehydrogenase activity
H9L22_05240	COG0194	GDP metabolic process
H9L22_05245	COG1758	RNA polymerase activity
H9L22_05250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9L22_05310	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H9L22_05315	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H9L22_05325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9L22_05335	COG1160	GTP binding
H9L22_05395	COG0667	Aldo Keto reductase
H9L22_05435	COG1609	Transcriptional regulator
H9L22_05440	COG0545	Peptidyl-prolyl cis-trans isomerase
H9L22_05450	COG0647	UMP catabolic process
H9L22_05455	COG0371	Dehydrogenase
H9L22_05460	COG1609	Transcriptional regulator
H9L22_05485	COG2813	Specifically methylates the guanine in position
H9L22_05485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9L22_05510	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9L22_05520	COG3030	protein affecting phage T7 exclusion by the F plasmid
H9L22_05550	COG0667	Aldo Keto reductase
H9L22_05605	COG0009	L-threonylcarbamoyladenylate synthase
H9L22_05610	COG0656	L-ascorbic acid biosynthetic process
H9L22_05630	COG1295	ribonuclease BN
H9L22_05680	COG0438	transferase activity, transferring glycosyl groups
H9L22_05695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9L22_05705	COG1028	Short-chain dehydrogenase reductase Sdr
H9L22_05715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9L22_05740	COG0730	response to heat
H9L22_05770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L22_05780	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H9L22_05785	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H9L22_05790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9L22_05800	COG0477	Major facilitator Superfamily
H9L22_05825	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H9L22_05830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L22_05835	COG0531	amino acid
H9L22_05840	COG0569	domain protein
H9L22_05860	COG0756	dUTP diphosphatase activity
H9L22_05885	COG1435	thymidine kinase activity
H9L22_05890	COG0438	transferase activity, transferring glycosyl groups
H9L22_05910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9L22_05925	COG1802	Transcriptional regulator
H9L22_05940	COG1139	Iron-sulfur cluster binding protein
H9L22_05945	COG1556	Lactate utilization protein
H9L22_05965	COG1074	ATP-dependent DNA helicase activity
H9L22_05980	COG3285	dna ligase
H9L22_05980	COG1793	dna ligase
H9L22_05995	COG0513	Belongs to the DEAD box helicase family
H9L22_06005	COG0613	PHP domain protein
H9L22_06020	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H9L22_06045	COG0653	protein targeting
H9L22_06050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9L22_06055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9L22_06060	COG5401	PFAM Sporulation and spore germination
H9L22_06065	COG5002	protein histidine kinase activity
H9L22_06070	COG0745	RESPONSE REGULATOR receiver
H9L22_06100	COG1678	Uncharacterized ACR, COG1678
H9L22_06115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9L22_06120	COG0741	lytic transglycosylase activity
H9L22_06120	COG1196	nuclear chromosome segregation
H9L22_06120	COG0739	heme binding
H9L22_06130	COG2884	Cell division ATP-binding protein ftsE
H9L22_06135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H9L22_06140	COG1610	YqeY-like protein
H9L22_06190	COG1522	sequence-specific DNA binding
H9L22_06195	COG2855	membrane
H9L22_06200	COG5006	permease, DMT superfamily
H9L22_06225	COG0205	6-phosphofructokinase activity
H9L22_06235	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9L22_06265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L22_06270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L22_06275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L22_06295	COG2304	oxidoreductase activity
H9L22_06300	COG2304	oxidoreductase activity
H9L22_06310	COG0714	Associated with various cellular activities
H9L22_06365	COG1028	Short-chain dehydrogenase reductase Sdr
H9L22_06400	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H9L22_06405	COG2197	response regulator
H9L22_06425	COG2197	response regulator
H9L22_06440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L22_06470	COG0358	DNA primase activity
H9L22_06490	COG0277	FAD linked oxidase domain protein
H9L22_06510	COG1653	transport
H9L22_06520	COG0395	ABC-type sugar transport system, permease component
H9L22_06525	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9L22_06530	COG1121	(ABC) transporter
H9L22_06535	COG1120	ATPase activity
H9L22_06540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9L22_06550	COG1381	Involved in DNA repair and RecF pathway recombination
H9L22_06565	COG1408	metallophosphoesterase
H9L22_06570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9L22_06575	COG0395	ABC-type sugar transport system, permease component
H9L22_06585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9L22_06595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9L22_06615	COG0343	queuine tRNA-ribosyltransferase activity
H9L22_06625	COG0484	heat shock protein binding
H9L22_06630	COG1420	regulation of RNA biosynthetic process
H9L22_06635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H9L22_06655	COG2160	L-arabinose isomerase activity
H9L22_06665	COG1609	Transcriptional regulator
H9L22_06670	COG1609	Transcriptional regulator
H9L22_06675	COG0483	inositol monophosphate 1-phosphatase activity
H9L22_06680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9L22_06685	COG0509	glycine decarboxylation via glycine cleavage system
H9L22_06690	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L22_06690	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L22_06705	COG0477	Major facilitator Superfamily
H9L22_06715	COG0237	dephospho-CoA kinase activity
H9L22_06725	COG0539	negative regulation of cytoplasmic translation
H9L22_06740	COG2050	protein possibly involved in aromatic compounds catabolism
H9L22_06755	COG0469	pyruvate kinase activity
H9L22_06765	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9L22_06780	COG1799	cell septum assembly
H9L22_06785	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9L22_06790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9L22_06795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L22_06800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9L22_06805	COG0772	Belongs to the SEDS family
H9L22_06810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9L22_06815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L22_06820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L22_06825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9L22_06830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9L22_06845	COG0275	rRNA processing
H9L22_06855	COG0714	Associated with various cellular activities
H9L22_06880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L22_06885	COG0587	DNA-directed DNA polymerase activity
H9L22_06925	COG0659	secondary active sulfate transmembrane transporter activity
H9L22_06940	COG1266	CAAX protease self-immunity
H9L22_06945	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9L22_06955	COG0473	3-isopropylmalate dehydrogenase activity
H9L22_06990	COG1349	DNA-binding transcription factor activity
H9L22_06995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9L22_07000	COG1063	alcohol dehydrogenase
H9L22_07005	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L22_07005	COG2213	PTS system mannitol-specific
H9L22_07010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9L22_07015	COG0440	acetolactate synthase activity
H9L22_07030	COG0537	adenosine 5'-monophosphoramidase activity
H9L22_07045	COG1597	lipid kinase activity
H9L22_07050	COG0805	protein transport
H9L22_07055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L22_07070	COG2378	regulation of single-species biofilm formation
H9L22_07080	COG0545	Peptidyl-prolyl cis-trans isomerase
H9L22_07090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H9L22_07110	COG4552	Acetyltransferase involved in intracellular survival and related
H9L22_07115	COG4974	Belongs to the 'phage' integrase family
H9L22_07125	COG0504	CTP synthase activity
H9L22_07130	COG0497	DNA recombination
H9L22_07135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9L22_07200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9L22_07205	COG0165	Argininosuccinate lyase
H9L22_07220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9L22_07225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H9L22_07245	COG4303	Ethanolamine ammonia lyase large subunit
H9L22_07255	COG0454	-acetyltransferase
H9L22_07255	COG0456	acetyltransferase
H9L22_07285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9L22_07290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L22_07295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9L22_07300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9L22_07305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9L22_07325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9L22_07330	COG0140	phosphoribosyl-ATP diphosphatase activity
H9L22_07335	COG0215	cysteine-tRNA ligase activity
H9L22_07385	COG1136	(ABC) transporter
H9L22_07400	COG0577	efflux transmembrane transporter activity
H9L22_07400	COG1136	(ABC) transporter
H9L22_07410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L22_07425	COG0792	nuclease activity
H9L22_07435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L22_07445	COG0335	large ribosomal subunit rRNA binding
H9L22_07450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9L22_07455	COG1053	succinate dehydrogenase
H9L22_07465	COG0336	Belongs to the RNA methyltransferase TrmD family
H9L22_07470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9L22_07475	COG1837	Belongs to the UPF0109 family
H9L22_07480	COG0228	four-way junction DNA binding
H9L22_07590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9L22_07625	COG0571	ribonuclease III activity
H9L22_07630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9L22_07640	COG1131	(ABC) transporter
H9L22_07650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9L22_07655	COG0742	ribosomal rna small subunit methyltransferase
H9L22_07660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9L22_07665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9L22_07670	COG1530	ribonuclease E activity
H9L22_07685	COG2807	transmembrane transport
H9L22_07760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9L22_07780	COG0105	UTP biosynthetic process
H9L22_07790	COG0285	dihydrofolate synthase activity
H9L22_07800	COG0525	valine-tRNA ligase activity
H9L22_07815	COG0740	serine-type endopeptidase activity
H9L22_07820	COG0740	serine-type endopeptidase activity
H9L22_07825	COG0628	permease
H9L22_07830	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9L22_07835	COG4667	esterase of the alpha-beta hydrolase superfamily
H9L22_07940	COG1175	transmembrane transport
H9L22_07950	COG3250	beta-galactosidase activity
H9L22_07990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9L22_08020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H9L22_08025	COG0540	Belongs to the ATCase OTCase family
H9L22_08030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L22_08045	COG1201	RNA secondary structure unwinding
H9L22_08050	COG1201	RNA secondary structure unwinding
H9L22_08060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9L22_08090	COG1595	DNA-templated transcription, initiation
H9L22_08110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9L22_08115	COG1162	GTPase activity
H9L22_08145	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H9L22_08160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9L22_08210	COG0556	nucleotide-excision repair
H9L22_08240	COG0495	leucyl-tRNA aminoacylation
H9L22_08275	COG0142	geranyltranstransferase activity
H9L22_08325	COG4989	oxidoreductase activity
H9L22_08350	COG1739	Uncharacterized protein family UPF0029
H9L22_08375	COG0395	ABC-type sugar transport system, permease component
H9L22_08390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L22_08410	COG2072	flavoprotein involved in K transport
H9L22_08430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9L22_08435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H9L22_08450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9L22_08455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9L22_08490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9L22_08490	COG0515	serine threonine protein kinase
H9L22_08495	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L22_08500	COG1937	Protein conserved in bacteria
H9L22_08520	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H9L22_08530	COG2835	tetraacyldisaccharide 4'-kinase activity
H9L22_08595	COG1316	TRANSCRIPTIONal
H9L22_08630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L22_08640	COG0424	maF-like protein
H9L22_08735	COG0328	RNA-DNA hybrid ribonuclease activity
H9L22_08740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L22_08750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9L22_08760	COG1079	Belongs to the binding-protein-dependent transport system permease family
H9L22_08765	COG4603	Belongs to the binding-protein-dependent transport system permease family
H9L22_08770	COG3845	ABC transporter
H9L22_08800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9L22_08805	COG0039	L-malate dehydrogenase activity
H9L22_08815	COG1486	melibiose metabolic process
H9L22_08820	COG1653	transport
H9L22_08825	COG1175	transmembrane transport
H9L22_08830	COG0395	ABC-type sugar transport system, permease component
H9L22_08850	COG0138	bifunctional purine biosynthesis protein purh
H9L22_08880	COG0045	succinate-CoA ligase (ADP-forming) activity
H9L22_08885	COG0739	heme binding
H9L22_08895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L22_08910	COG3119	arylsulfatase activity
H9L22_08915	COG0395	ABC-type sugar transport system, permease component
H9L22_08920	COG0395	ABC-type sugar transport system, permease component
H9L22_08925	COG1175	transmembrane transport
H9L22_08940	COG2197	response regulator
H9L22_08945	COG3850	Histidine kinase
H9L22_08970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9L22_08970	COG0519	Catalyzes the synthesis of GMP from XMP
H9L22_08985	COG0494	nUDIX hydrolase
H9L22_09000	COG1131	(ABC) transporter
H9L22_09005	COG1309	transcriptional regulator
H9L22_09010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L22_09020	COG1605	Chorismate mutase
H9L22_09020	COG0287	Prephenate dehydrogenase
H9L22_09025	COG0516	GMP reductase activity
H9L22_09035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9L22_09040	COG0210	DNA helicase
H9L22_09045	COG0459	protein refolding
H9L22_09055	COG1984	allophanate hydrolase subunit 2
H9L22_09085	COG3845	ABC transporter
H9L22_09125	COG0601	transmembrane transport
H9L22_09130	COG0747	negative chemotaxis
H9L22_09135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9L22_09140	COG0456	acetyltransferase
H9L22_09150	COG0802	atpase or kinase
H9L22_09155	COG0513	Belongs to the DEAD box helicase family
H9L22_09180	COG0736	holo-[acyl-carrier-protein] synthase activity
H9L22_09185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9L22_09190	COG1072	(Pantothenic acid kinase))
H9L22_09195	COG2860	membrane
H9L22_09200	COG0006	proline dipeptidase activity
H9L22_09220	COG2239	Acts as a magnesium transporter
H9L22_09240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9L22_09255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L22_09260	COG4122	O-methyltransferase activity
H9L22_09265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9L22_09270	COG0297	glycogen (starch) synthase activity
H9L22_09285	COG1611	Belongs to the LOG family
H9L22_09290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L22_09330	COG2171	N-acyltransferase activity
H9L22_09355	COG0616	signal peptide processing
H9L22_09375	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H9L22_09395	COG1335	isochorismatase
H9L22_09410	COG2391	methyltransferase activity
H9L22_09415	COG0425	Belongs to the sulfur carrier protein TusA family
H9L22_09430	COG2205	protein histidine kinase activity
H9L22_09450	COG4584	PFAM Integrase catalytic
H9L22_09485	COG1045	serine acetyltransferase
H9L22_09510	COG3250	beta-galactosidase activity
H9L22_09535	COG0395	ABC-type sugar transport system, permease component
H9L22_09570	COG0534	Mate efflux family protein
H9L22_09590	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H9L22_09620	COG2211	Major facilitator Superfamily
H9L22_09700	COG1522	sequence-specific DNA binding
H9L22_09705	COG1280	lysine exporter protein (LysE YggA)
H9L22_09710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9L22_09745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L22_09755	COG3609	addiction module antidote protein, CC2985 family
H9L22_09775	COG2826	transposase and inactivated derivatives, IS30 family
H9L22_09820	COG0012	GTP binding
H9L22_09825	COG4607	ABC-type enterochelin transport system periplasmic component
H9L22_09830	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L22_09835	COG4605	iron ion homeostasis
H9L22_09840	COG4604	ABC transporter, ATP-binding protein
H9L22_09845	COG1362	aminopeptidase activity
H9L22_09865	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9L22_09880	COG1570	exodeoxyribonuclease VII activity
H9L22_09885	COG1722	exodeoxyribonuclease VII activity
H9L22_09895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9L22_09930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H9L22_09940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L22_09995	COG1254	Belongs to the acylphosphatase family
H9L22_10000	COG2124	cytochrome p450
H9L22_10025	COG0494	nUDIX hydrolase
H9L22_10035	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H9L22_10045	COG1793	dna ligase
H9L22_10070	COG2268	Band 7 protein
H9L22_10105	COG0148	phosphopyruvate hydratase activity
H9L22_10130	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9L22_10135	COG1609	Transcriptional regulator
H9L22_10145	COG1070	Carbohydrate kinase
H9L22_10155	COG0577	efflux transmembrane transporter activity
H9L22_10155	COG1136	(ABC) transporter
H9L22_10160	COG0577	efflux transmembrane transporter activity
H9L22_10160	COG1136	(ABC) transporter
H9L22_10175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9L22_10195	COG0519	Catalyzes the synthesis of GMP from XMP
H9L22_10270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9L22_10330	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L22_10340	COG2723	6-phospho-beta-galactosidase activity
H9L22_10355	COG0601	transmembrane transport
H9L22_10365	COG1309	transcriptional regulator
H9L22_10370	COG2217	Heavy metal translocating P-type atpase
H9L22_10375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9L22_10385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L22_10415	COG1518	maintenance of DNA repeat elements
H9L22_10470	COG2026	Addiction module toxin, RelE StbE family
H9L22_10505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9L22_10630	COG2337	Toxic component of a toxin-antitoxin (TA) module
H9L22_10645	COG2610	gluconate transmembrane transporter activity
H9L22_10650	COG2084	Dehydrogenase
H9L22_10680	COG2186	Transcriptional regulator
H9L22_10695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9L22_10710	COG2319	Wd-40 repeat
H9L22_10720	COG2826	transposase and inactivated derivatives, IS30 family
H9L22_10725	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H9L22_10875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9L22_10895	COG0542	response to heat
H9L22_10915	COG2815	serine threonine protein kinase
H9L22_10915	COG0515	serine threonine protein kinase
H9L22_10965	COG1518	maintenance of DNA repeat elements
H9L22_10970	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H9L22_11030	COG0582	viral genome integration into host DNA
H9L22_11045	COG4974	Belongs to the 'phage' integrase family
H9L22_11165	COG2409	Drug exporters of the RND superfamily
H9L22_11210	COG1970	mechanosensitive ion channel activity
H9L22_11225	COG0395	ABC-type sugar transport system, permease component
H9L22_11230	COG1175	transmembrane transport
H9L22_11240	COG3250	beta-galactosidase activity
H9L22_11270	COG0167	dihydroorotate dehydrogenase activity
H9L22_11285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L22_11310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9L22_11330	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H9L22_11335	COG2252	PERMEase
H9L22_11340	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L22_11345	COG0395	ABC-type sugar transport system, permease component
H9L22_11350	COG1175	transmembrane transport
H9L22_11355	COG2182	Extracellular solute-binding protein
H9L22_11360	COG1609	Transcriptional regulator
H9L22_11380	COG1278	Cold shock
H9L22_11385	COG0363	glucosamine-6-phosphate deaminase activity
H9L22_11395	COG0494	nUDIX hydrolase
H9L22_11405	COG1621	beta-fructofuranosidase activity
H9L22_11480	COG1482	cell wall glycoprotein biosynthetic process
H9L22_11525	COG0626	cystathionine gamma-synthase activity
H9L22_11560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9L22_11580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9L22_11585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9L22_11590	COG1329	Transcriptional regulator
H9L22_11600	COG0745	RESPONSE REGULATOR receiver
H9L22_11605	COG5002	protein histidine kinase activity
H9L22_11610	COG0704	Plays a role in the regulation of phosphate uptake
H9L22_11615	COG0726	polysaccharide deacetylase
H9L22_11620	COG0588	phosphoglycerate mutase activity
H9L22_11665	COG0246	Mannitol dehydrogenase
H9L22_11690	COG1028	Short-chain dehydrogenase reductase Sdr
H9L22_11700	COG0022	dehydrogenase e1 component
H9L22_11705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L22_11710	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L22_11715	COG1349	DNA-binding transcription factor activity
H9L22_11795	COG1595	DNA-templated transcription, initiation
H9L22_11800	COG3958	Transketolase
H9L22_11805	COG3959	Transketolase, thiamine diphosphate binding domain
H9L22_11810	COG1082	Xylose isomerase domain protein TIM barrel
H9L22_11815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9L22_11820	COG1129	ABC transporter
H9L22_11835	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9L22_11870	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
H9L22_11880	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9L22_11890	COG2197	response regulator
H9L22_11895	COG2197	response regulator
H9L22_11935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L22_11940	COG0191	fructose-bisphosphate aldolase activity
H9L22_11960	COG1704	LemA family
H9L22_11965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9L22_11980	COG0534	Mate efflux family protein
H9L22_11990	COG2133	pyrroloquinoline quinone binding
H9L22_12005	COG1115	amino acid carrier protein
H9L22_12025	COG1063	alcohol dehydrogenase
H9L22_12030	COG0156	8-amino-7-oxononanoate synthase activity
H9L22_12040	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H9L22_12045	COG0352	thiamine-phosphate diphosphorylase activity
H9L22_12045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9L22_12045	COG0351	phosphomethylpyrimidine kinase
H9L22_12050	COG0351	phosphomethylpyrimidine kinase
H9L22_12055	COG0352	thiamine-phosphate diphosphorylase activity
H9L22_12055	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9L22_12055	COG0351	phosphomethylpyrimidine kinase
H9L22_12060	COG1285	pathogenesis
H9L22_12075	COG0058	SHG alpha-glucan phosphorylase activity
H9L22_12105	COG0789	Transcriptional regulator
H9L22_12110	COG0484	heat shock protein binding
H9L22_12115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9L22_12140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H9L22_12170	COG0745	RESPONSE REGULATOR receiver
H9L22_12175	COG2205	protein histidine kinase activity
H9L22_12180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H9L22_12185	COG0717	Belongs to the dCTP deaminase family
H9L22_12195	COG1305	Transglutaminase-like
H9L22_12205	COG0714	Associated with various cellular activities
H9L22_12215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H9L22_12225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9L22_12255	COG0489	protein tyrosine kinase activity
H9L22_12260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L22_12265	COG0489	protein tyrosine kinase activity
H9L22_12275	COG0681	Belongs to the peptidase S26 family
H9L22_12290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L22_12295	COG0489	protein tyrosine kinase activity
H9L22_12300	COG1086	Polysaccharide biosynthesis protein
H9L22_12310	COG0297	glycogen (starch) synthase activity
H9L22_12320	COG3344	reverse transcriptase
H9L22_12385	COG1086	Polysaccharide biosynthesis protein
H9L22_12395	COG1316	TRANSCRIPTIONal
H9L22_12445	COG1653	transport
H9L22_12450	COG0433	COG0433 Predicted ATPase
H9L22_12490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9L22_12505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H9L22_12535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H9L22_12540	COG0584	glycerophosphoryl diester phosphodiesterase
H9L22_12555	COG2182	Extracellular solute-binding protein
H9L22_12560	COG1175	transmembrane transport
H9L22_12565	COG0395	ABC-type sugar transport system, permease component
H9L22_12570	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L22_12575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H9L22_12580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9L22_12585	COG1737	Transcriptional regulator
H9L22_12600	COG2301	Belongs to the HpcH HpaI aldolase family
H9L22_12640	COG1609	Transcriptional regulator
H9L22_12665	COG1175	transmembrane transport
H9L22_12670	COG3833	ABC-type maltose transport systems, permease component
H9L22_12675	COG3842	ATPase activity
H9L22_12680	COG0383	alpha-mannosidase activity
H9L22_12695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L22_12710	COG1316	TRANSCRIPTIONal
H9L22_12725	COG0564	pseudouridine synthase activity
H9L22_12735	COG0604	alcohol dehydrogenase
H9L22_12740	COG0438	transferase activity, transferring glycosyl groups
H9L22_12755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9L22_12760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9L22_12800	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H9L22_12855	COG0137	argininosuccinate synthase activity
H9L22_12865	COG0561	phosphatase activity
H9L22_12870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9L22_12875	COG2814	Major facilitator Superfamily
H9L22_12895	COG1404	Belongs to the peptidase S8 family
H9L22_12900	COG1674	ftsk spoiiie
H9L22_12940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9L22_12945	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9L22_12955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L22_12965	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L22_12970	COG0022	dehydrogenase e1 component
H9L22_12990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9L22_12995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L22_13005	COG3850	Histidine kinase
H9L22_13005	COG0642	Histidine kinase
H9L22_13010	COG2814	Major facilitator Superfamily
H9L22_13020	COG0673	inositol 2-dehydrogenase activity
H9L22_13035	COG2390	Transcriptional regulator
H9L22_13040	COG1064	alcohol dehydrogenase
H9L22_13050	COG0662	Cupin 2, conserved barrel domain protein
H9L22_13080	COG1846	Transcriptional regulator
H9L22_13090	COG1760	l-serine dehydratase
H9L22_13105	COG0501	Belongs to the peptidase M48B family
H9L22_13110	COG0359	binds to the 23S rRNA
H9L22_13115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9L22_13125	COG0360	Binds together with S18 to 16S ribosomal RNA
H9L22_13135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9L22_13145	COG1022	Amp-dependent synthetase and ligase
H9L22_13150	COG0488	(ABC) transporter
H9L22_13155	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H9L22_13175	COG2111	Na H antiporter
H9L22_13175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H9L22_13180	COG1006	Multisubunit Na H antiporter MnhC subunit
H9L22_13185	COG0651	ATP synthesis coupled electron transport
H9L22_13190	COG1863	multisubunit Na H antiporter MnhE subunit
H9L22_13200	COG1320	monovalent cation:proton antiporter activity
H9L22_13205	COG2154	pterin-4-alpha-carbinolamine dehydratase
H9L22_13210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L22_13220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9L22_13245	COG0300	oxidoreductase activity
H9L22_13250	COG0318	PFAM AMP-dependent synthetase and ligase
H9L22_13250	COG0204	Acyl-transferase
H9L22_13325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9L22_13325	COG0574	Belongs to the PEP-utilizing enzyme family
H9L22_13335	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9L22_13340	COG4214	carbohydrate transport
H9L22_13355	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H9L22_13360	COG5650	phosphatidylinositol metabolic process
H9L22_13390	COG0668	transmembrane transport
H9L22_13455	COG1309	transcriptional regulator
H9L22_13480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9L22_13520	COG2409	Drug exporters of the RND superfamily
H9L22_13530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L22_13535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9L22_13540	COG2203	Gaf domain
H9L22_13540	COG4585	Histidine kinase
H9L22_13545	COG2197	response regulator
H9L22_13555	COG0024	Methionine aminopeptidase
H9L22_13585	COG4608	Belongs to the ABC transporter superfamily
H9L22_13590	COG0444	Belongs to the ABC transporter superfamily
H9L22_13595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L22_13600	COG0601	transmembrane transport
H9L22_13615	COG2188	Transcriptional regulator
H9L22_13625	COG1653	transport
H9L22_13650	COG2076	Multidrug Resistance protein
H9L22_13655	COG2076	Multidrug Resistance protein
H9L22_13680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H9L22_13685	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H9L22_13695	COG2354	Protein conserved in bacteria
H9L22_13705	COG0745	RESPONSE REGULATOR receiver
H9L22_13725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L22_13735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L22_13745	COG0747	negative chemotaxis
H9L22_13785	COG0708	Exodeoxyribonuclease III
H9L22_13795	COG2409	Drug exporters of the RND superfamily
H9L22_13845	COG1053	succinate dehydrogenase
H9L22_13850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9L22_13860	COG4948	Mandelate Racemase Muconate Lactonizing
H9L22_13875	COG0667	Aldo Keto reductase
H9L22_13900	COG2826	transposase and inactivated derivatives, IS30 family
H9L22_13935	COG1285	pathogenesis
H9L22_13945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H9L22_13980	COG1486	melibiose metabolic process
H9L22_13995	COG1175	transmembrane transport
H9L22_14000	COG0395	ABC-type sugar transport system, permease component
H9L22_14015	COG1609	Transcriptional regulator
H9L22_14020	COG1501	Belongs to the glycosyl hydrolase 31 family
H9L22_14070	COG1396	sequence-specific DNA binding
H9L22_14115	COG1609	Transcriptional regulator
H9L22_14120	COG2182	Extracellular solute-binding protein
H9L22_14130	COG0395	ABC-type sugar transport system, permease component
H9L22_14155	COG1069	ribulokinase activity
H9L22_14165	COG1129	ABC transporter
H9L22_14170	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9L22_14175	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9L22_14280	COG1757	Na H antiporter
H9L22_14285	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H9L22_14295	COG1185	polyribonucleotide nucleotidyltransferase activity
H9L22_14350	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
H9L22_14405	COG3266	domain, Protein
H9L22_14435	COG0739	heme binding
H9L22_14435	COG1196	nuclear chromosome segregation
H9L22_14435	COG0741	lytic transglycosylase activity
H9L22_14445	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
H9L22_14450	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9L22_14455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H9L22_14460	COG0592	DNA-directed DNA polymerase activity
H9L22_14465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9L22_14470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H9L22_14475	COG0594	ribonuclease P activity
H9L22_14485	COG0706	membrane insertase activity
H9L22_14495	COG0357	Ribosomal RNA small subunit methyltransferase G
H9L22_14520	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L22_14535	COG3118	belongs to the thioredoxin family
H9L22_14540	COG0492	ferredoxin-NADP+ reductase activity
H9L22_14550	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H9L22_14565	COG1414	Transcriptional regulator
H9L22_14570	COG0800	Aldolase
H9L22_14575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L22_14580	COG2721	sulfolactate sulfo-lyase activity
H9L22_14585	COG1335	isochorismatase
H9L22_14590	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9L22_14660	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9L22_14675	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H9L22_14695	COG3328	transposase activity
H9L22_14715	COG1609	Transcriptional regulator
H9L22_14740	COG1653	transport
H9L22_14745	COG1175	transmembrane transport
H9L22_14750	COG0395	ABC-type sugar transport system, permease component
H9L22_14760	COG0673	inositol 2-dehydrogenase activity
H9L22_14785	COG1609	Transcriptional regulator
H9L22_14845	COG1028	Short-chain dehydrogenase reductase Sdr
H9L22_14860	COG3848	Pyruvate phosphate dikinase
H9L22_14860	COG0574	Belongs to the PEP-utilizing enzyme family
H9L22_14865	COG1309	transcriptional regulator
H9L22_14875	COG1312	Catalyzes the dehydration of D-mannonate
H9L22_14895	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L22_14900	COG2211	Major facilitator Superfamily
H9L22_14925	COG4585	Histidine kinase
H9L22_14960	COG1461	Dihydroxyacetone kinase
H9L22_14965	COG2376	Dihydroxyacetone kinase
H9L22_14970	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9L22_14975	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9L22_14980	COG1129	ABC transporter
H9L22_15065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9L22_15075	COG1012	belongs to the aldehyde dehydrogenase family
H9L22_15080	COG1082	Xylose isomerase domain protein TIM barrel
H9L22_15090	COG3718	enzyme involved in inositol metabolism
H9L22_15100	COG2188	Transcriptional regulator
H9L22_15105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9L22_15110	COG0673	inositol 2-dehydrogenase activity
H9L22_15115	COG3189	MarR family transcriptional regulator
H9L22_15125	COG1803	Methylglyoxal synthase
H9L22_15135	COG2115	Belongs to the xylose isomerase family
H9L22_15150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9L22_15180	COG0705	Rhomboid family
H9L22_15180	COG0457	Tetratricopeptide repeat
H9L22_15295	COG3344	reverse transcriptase
H9L22_15335	COG3665	Urea carboxylase-associated protein
H9L22_15340	COG0456	acetyltransferase
H9L22_15350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L22_15365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L22_15370	COG0438	transferase activity, transferring glycosyl groups
H9L22_15405	COG1278	Cold shock
H9L22_15415	COG1764	response to oxidative stress
H9L22_15420	COG0673	inositol 2-dehydrogenase activity
H9L22_15440	COG0419	ATPase involved in DNA repair
H9L22_15445	COG0420	3'-5' exonuclease activity
H9L22_15465	COG0730	response to heat
H9L22_15470	COG3119	arylsulfatase activity
H9L22_15485	COG0395	ABC-type sugar transport system, permease component
H9L22_15490	COG1175	transmembrane transport
H9L22_15500	COG1940	carbohydrate kinase activity
H9L22_15525	COG0513	Belongs to the DEAD box helicase family
H9L22_15545	COG4172	Belongs to the ABC transporter superfamily
H9L22_15550	COG0601	transmembrane transport
H9L22_15585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L22_15620	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9L22_15635	COG3311	Transcriptional regulator
H9L22_15665	COG0189	ligase activity
H9L22_15675	COG3655	Transcriptional regulator
H9L22_15720	COG1272	protein, Hemolysin III
H9L22_15750	COG1609	Transcriptional regulator
H9L22_15755	COG1929	Belongs to the glycerate kinase type-1 family
H9L22_15760	COG5426	von Willebrand factor, type A
H9L22_15790	COG4585	Histidine kinase
H9L22_15795	COG2197	response regulator
H9L22_15800	COG4152	abc transporter atp-binding protein
H9L22_15805	COG1668	transmembrane transport
H9L22_15845	COG3237	CsbD-like
H9L22_15860	COG1064	alcohol dehydrogenase
H9L22_15885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9L22_15905	COG0318	PFAM AMP-dependent synthetase and ligase
H9L22_15935	COG1609	Transcriptional regulator
H9L22_15965	COG0640	Transcriptional regulator
H9L22_15975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L22_15985	COG1132	(ABC) transporter
H9L22_16010	COG1653	transport
H9L22_16015	COG1175	transmembrane transport
H9L22_16020	COG0395	ABC-type sugar transport system, permease component
H9L22_16035	COG3250	beta-galactosidase activity
H9L22_16075	COG1295	ribonuclease BN
H9L22_16080	COG0439	Biotin carboxylase
H9L22_16110	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H9L22_16110	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H9L22_16165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L22_16175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H9L22_16185	COG1597	lipid kinase activity
H9L22_16220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L22_16230	COG1120	ATPase activity
H9L22_16240	COG1393	Belongs to the ArsC family
H9L22_16295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L22_16305	COG1397	ADP-ribosylglycohydrolase
H9L22_16315	COG3250	beta-galactosidase activity
H9L22_16320	COG0395	ABC-type sugar transport system, permease component
H9L22_16325	COG1175	transmembrane transport
H9L22_16335	COG1609	Transcriptional regulator
H9L22_16360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L22_16375	COG0305	Participates in initiation and elongation during chromosome replication
H9L22_16380	COG1937	Protein conserved in bacteria
H9L22_16395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9L22_16430	COG0438	transferase activity, transferring glycosyl groups
H9L22_16435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H9L22_16445	COG1294	oxidase, subunit
H9L22_16450	COG1271	oxidase subunit
H9L22_16460	COG2326	polyphosphate kinase activity
H9L22_16465	COG2514	catechol 2,3-dioxygenase activity
H9L22_16535	COG3250	beta-galactosidase activity
H9L22_16545	COG0697	spore germination
H9L22_16550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9L22_16555	COG0393	Putative heavy-metal-binding
H9L22_16575	COG0515	serine threonine protein kinase
H9L22_16580	COG0768	penicillin binding
H9L22_16600	COG1716	ATPase activity
H9L22_16635	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L22_16680	COG1028	Short-chain dehydrogenase reductase Sdr
H9L22_16685	COG0673	inositol 2-dehydrogenase activity
H9L22_16695	COG3401	FG-GAP repeat protein
H9L22_16715	COG0673	inositol 2-dehydrogenase activity
H9L22_16720	COG2755	lipolytic protein G-D-S-L family
H9L22_16740	COG1175	transmembrane transport
H9L22_16745	COG0395	ABC-type sugar transport system, permease component
H9L22_16805	COG1070	Carbohydrate kinase
H9L22_16815	COG0438	transferase activity, transferring glycosyl groups
H9L22_16845	COG3250	beta-galactosidase activity
H9L22_16850	COG3119	arylsulfatase activity
H9L22_16860	COG1175	transmembrane transport
H9L22_16865	COG0395	ABC-type sugar transport system, permease component
H9L22_16870	COG1609	Transcriptional regulator
H9L22_16875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H9L22_16885	COG3458	cephalosporin-C deacetylase activity
H9L22_16920	COG0166	Belongs to the GPI family
H9L22_16935	COG1879	ABC-type sugar transport system periplasmic component
H9L22_16940	COG1129	ABC transporter
H9L22_16970	COG0018	arginyl-trna synthetase
H9L22_16975	COG1940	carbohydrate kinase activity
H9L22_16995	COG0205	6-phosphofructokinase activity
H9L22_17065	COG0714	Associated with various cellular activities
H9L22_17075	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H9L22_17080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L22_17085	COG2326	polyphosphate kinase activity
H9L22_17090	COG0546	phosphoglycolate phosphatase activity
H9L22_17095	COG1464	Belongs to the NlpA lipoprotein family
H9L22_17100	COG2011	ABC-type metal ion transport system permease component
H9L22_17105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9L22_17130	COG1473	amidohydrolase
H9L22_17135	COG2357	RelA SpoT domain protein
H9L22_17160	COG0277	FAD linked oxidase domain protein
H9L22_17165	COG2095	MarC family integral membrane protein
H9L22_17175	COG3830	Belongs to the UPF0237 family
H9L22_17175	COG0560	Phosphoserine phosphatase
H9L22_17180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L22_17190	COG2813	Specifically methylates the guanine in position
H9L22_17195	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
H9L22_17220	COG0653	protein targeting
H9L22_17225	COG0653	protein targeting
H9L22_17230	COG0653	protein targeting
H9L22_17245	COG1136	(ABC) transporter
H9L22_17255	COG2197	response regulator
H9L22_17320	COG1201	RNA secondary structure unwinding
H9L22_17345	COG1937	Protein conserved in bacteria
H9L22_17350	COG2217	Heavy metal translocating P-type atpase
H9L22_17365	COG1116	anion transmembrane transporter activity
H9L22_17390	COG2205	protein histidine kinase activity
H9L22_17395	COG0745	RESPONSE REGULATOR receiver
H9L22_17455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9L22_17470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H9L22_17515	COG0305	Participates in initiation and elongation during chromosome replication
H9L22_17515	COG0358	DNA primase activity
H9L22_17590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9L22_17595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9L22_17605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L22_17625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9L22_17630	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H9L22_17650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L22_17750	COG0667	Aldo Keto reductase
H9L22_17775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9L22_17790	COG1774	PSP1 C-terminal conserved region
H9L22_17840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9L22_17845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9L22_17855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9L22_17860	COG2027	D-alanyl-D-alanine carboxypeptidase
H9L22_17870	COG0037	tRNA processing
H9L22_17905	COG2161	toxin-antitoxin pair type II binding
H9L22_17910	COG2026	Addiction module toxin, RelE StbE family
H9L22_17935	COG2217	Heavy metal translocating P-type atpase
H9L22_17955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9L22_17975	COG0302	gtp cyclohydrolase
H9L22_17980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9L22_17985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9L22_18005	COG0649	NAD binding
H9L22_18020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9L22_18080	COG1082	Xylose isomerase domain protein TIM barrel
H9L22_18100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9L22_18115	COG1648	precorrin-2 dehydrogenase activity
H9L22_18115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9L22_18125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L22_18130	COG0785	Cytochrome C biogenesis protein
H9L22_18140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9L22_18155	COG1028	Short-chain dehydrogenase reductase Sdr
H9L22_18165	COG1472	Belongs to the glycosyl hydrolase 3 family