locus-tag	class	description
BW733_00005	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BW733_00020	COG0653	protein targeting
BW733_00025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BW733_00035	COG5401	PFAM Sporulation and spore germination
BW733_00040	COG5002	protein histidine kinase activity
BW733_00040	COG5000	phosphorelay sensor kinase activity
BW733_00045	COG0745	RESPONSE REGULATOR receiver
BW733_00065	COG1678	Uncharacterized ACR, COG1678
BW733_00080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BW733_00085	COG0739	heme binding
BW733_00085	COG1196	nuclear chromosome segregation
BW733_00085	COG0741	lytic transglycosylase activity
BW733_00095	COG2884	Cell division ATP-binding protein ftsE
BW733_00100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BW733_00120	COG2801	Transposase and inactivated derivatives
BW733_00160	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BW733_00165	COG0732	type I restriction modification DNA specificity domain
BW733_00170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BW733_00180	COG2801	Transposase and inactivated derivatives
BW733_00180	COG3415	Transposase
BW733_00195	COG0205	6-phosphofructokinase activity
BW733_00205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BW733_00215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BW733_00215	COG1796	DNA polymerase
BW733_00220	COG1648	precorrin-2 dehydrogenase activity
BW733_00220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW733_00225	COG1115	amino acid carrier protein
BW733_00245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BW733_00250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BW733_00275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BW733_00280	COG2304	oxidoreductase activity
BW733_00285	COG2304	oxidoreductase activity
BW733_00295	COG0714	Associated with various cellular activities
BW733_00365	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BW733_00400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BW733_00410	COG0277	FAD linked oxidase domain protein
BW733_00430	COG0803	Belongs to the bacterial solute-binding protein 9 family
BW733_00435	COG1121	(ABC) transporter
BW733_00440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BW733_00450	COG1381	Involved in DNA repair and RecF pathway recombination
BW733_00455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BW733_00465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BW733_00475	COG0395	ABC-type sugar transport system, permease component
BW733_00480	COG1175	transmembrane transport
BW733_00490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BW733_00505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BW733_00525	COG0343	queuine tRNA-ribosyltransferase activity
BW733_00535	COG0484	heat shock protein binding
BW733_00550	COG2160	L-arabinose isomerase activity
BW733_00565	COG1609	Transcriptional regulator
BW733_00585	COG1131	(ABC) transporter
BW733_00590	COG1725	Transcriptional regulator
BW733_00595	COG2723	6-phospho-beta-galactosidase activity
BW733_00610	COG1175	transmembrane transport
BW733_00615	COG0395	ABC-type sugar transport system, permease component
BW733_00620	COG1643	Atp-dependent helicase
BW733_00630	COG0481	GTPase activity
BW733_00635	COG2801	Transposase and inactivated derivatives
BW733_00645	COG0268	Binds directly to 16S ribosomal RNA
BW733_00660	COG1191	sigma factor activity
BW733_00670	COG0673	inositol 2-dehydrogenase activity
BW733_00690	COG1596	polysaccharide export
BW733_00690	COG1555	photosystem II stabilization
BW733_00695	COG0495	leucyl-tRNA aminoacylation
BW733_00700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW733_00750	COG0583	DNA-binding transcription factor activity
BW733_00755	COG2855	membrane
BW733_00770	COG2910	NAD(P)H-binding
BW733_00775	COG1733	regulation of RNA biosynthetic process
BW733_00790	COG1937	Protein conserved in bacteria
BW733_00795	COG0446	pyridine nucleotide-disulphide oxidoreductase
BW733_00800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW733_00835	COG1484	DNA-dependent DNA replication
BW733_00855	COG0582	viral genome integration into host DNA
BW733_00860	COG0582	viral genome integration into host DNA
BW733_00865	COG4974	Belongs to the 'phage' integrase family
BW733_00875	COG0464	growth
BW733_00940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BW733_00955	COG0667	Aldo Keto reductase
BW733_00960	COG3118	belongs to the thioredoxin family
BW733_00970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW733_00995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BW733_01000	COG2871	sodium ion transport
BW733_01010	COG0215	cysteine-tRNA ligase activity
BW733_01015	COG0215	cysteine-tRNA ligase activity
BW733_01025	COG1309	transcriptional regulator
BW733_01035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BW733_01040	COG4977	sequence-specific DNA binding
BW733_01040	COG1917	Cupin 2, conserved barrel domain protein
BW733_01080	COG1196	nuclear chromosome segregation
BW733_01080	COG0741	lytic transglycosylase activity
BW733_01080	COG0739	heme binding
BW733_01180	COG0181	hydroxymethylbilane synthase activity
BW733_01185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BW733_01195	COG0181	hydroxymethylbilane synthase activity
BW733_01205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BW733_01210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BW733_01225	COG0799	negative regulation of ribosome biogenesis
BW733_01230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BW733_01235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BW733_01245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BW733_01250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BW733_01255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BW733_01260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BW733_01265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BW733_01275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BW733_01285	COG0246	Mannitol dehydrogenase
BW733_01295	COG1648	precorrin-2 dehydrogenase activity
BW733_01295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW733_01300	COG1797	cobyrinic acid a,c-diamide synthase activity
BW733_01330	COG0310	cobalt ion transport
BW733_01340	COG1648	precorrin-2 dehydrogenase activity
BW733_01340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW733_01360	COG1492	cobalamin metabolic process
BW733_01365	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BW733_01380	COG1185	polyribonucleotide nucleotidyltransferase activity
BW733_01385	COG0506	proline dehydrogenase activity
BW733_01385	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BW733_01385	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BW733_01390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BW733_01405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BW733_01410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BW733_01415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BW733_01440	COG0779	Required for maturation of 30S ribosomal subunits
BW733_01455	COG0442	prolyl-tRNA aminoacylation
BW733_01465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BW733_01470	COG0750	zinc metalloprotease
BW733_01475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BW733_01490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW733_01510	COG2226	methyltransferase
BW733_01515	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BW733_01515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BW733_01535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BW733_01545	COG0233	cytoplasmic translational termination
BW733_01550	COG0528	UMP kinase activity
BW733_01555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BW733_01560	COG0052	Belongs to the universal ribosomal protein uS2 family
BW733_01565	COG0739	heme binding
BW733_01570	COG4974	Belongs to the 'phage' integrase family
BW733_01575	COG0242	peptide deformylase activity
BW733_01595	COG1737	Transcriptional regulator
BW733_01600	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BW733_01635	COG1119	ATPase activity
BW733_01640	COG0656	L-ascorbic acid biosynthetic process
BW733_01650	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_01670	COG2226	methyltransferase
BW733_01675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BW733_01680	COG2190	(PTS) system
BW733_01680	COG2211	Major facilitator Superfamily
BW733_01685	COG0366	Alpha amylase catalytic
BW733_01690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW733_01700	COG2197	response regulator
BW733_01705	COG3415	Transposase
BW733_01705	COG2801	Transposase and inactivated derivatives
BW733_01720	COG2267	carboxylic ester hydrolase activity
BW733_01735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BW733_01740	COG0396	ATPase activity
BW733_01765	COG1131	(ABC) transporter
BW733_01795	COG2814	Major facilitator Superfamily
BW733_01810	COG1136	(ABC) transporter
BW733_01865	COG0109	protoheme IX farnesyltransferase activity
BW733_01880	COG0363	glucosamine-6-phosphate deaminase activity
BW733_01895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BW733_01900	COG0149	triose-phosphate isomerase activity
BW733_01905	COG0126	phosphoglycerate kinase activity
BW733_01910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BW733_01915	COG1481	regulation of sporulation
BW733_01925	COG1660	Displays ATPase and GTPase activities
BW733_01940	COG1122	ATPase activity
BW733_01950	COG0322	excinuclease ABC activity
BW733_01960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW733_01980	COG0556	nucleotide-excision repair
BW733_01995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BW733_02000	COG0509	glycine decarboxylation via glycine cleavage system
BW733_02005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW733_02005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW733_02010	COG0477	Major facilitator Superfamily
BW733_02020	COG0237	dephospho-CoA kinase activity
BW733_02025	COG0539	negative regulation of cytoplasmic translation
BW733_02030	COG2801	Transposase and inactivated derivatives
BW733_02045	COG2050	protein possibly involved in aromatic compounds catabolism
BW733_02060	COG0469	pyruvate kinase activity
BW733_02070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BW733_02085	COG1799	cell septum assembly
BW733_02100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BW733_02105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BW733_02110	COG0772	Belongs to the SEDS family
BW733_02115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BW733_02120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW733_02125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BW733_02135	COG0768	penicillin binding
BW733_02145	COG0275	rRNA processing
BW733_02150	COG2001	Belongs to the MraZ family
BW733_02155	COG0714	Associated with various cellular activities
BW733_02190	COG0587	DNA-directed DNA polymerase activity
BW733_02225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BW733_02225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BW733_02230	COG3973	AAA domain
BW733_02240	COG0142	geranyltranstransferase activity
BW733_02245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BW733_02255	COG2815	serine threonine protein kinase
BW733_02255	COG0515	serine threonine protein kinase
BW733_02270	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BW733_02275	COG2197	response regulator
BW733_02310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BW733_02320	COG0088	Forms part of the polypeptide exit tunnel
BW733_02325	COG3214	Protein conserved in bacteria
BW733_02335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BW733_02345	COG1845	cytochrome c oxidase, subunit III
BW733_02350	COG2010	Cytochrome c
BW733_02355	COG0723	plastoquinol--plastocyanin reductase activity
BW733_02360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BW733_02365	COG3831	ATPase activity
BW733_02370	COG0714	Associated with various cellular activities
BW733_02395	COG4585	Histidine kinase
BW733_02400	COG2197	response regulator
BW733_02405	COG4152	abc transporter atp-binding protein
BW733_02420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BW733_02425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BW733_02465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BW733_02485	COG2801	Transposase and inactivated derivatives
BW733_02490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW733_02495	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW733_02500	COG1811	Na channel or pump
BW733_02505	COG0321	lipoyl(octanoyl) transferase activity
BW733_02510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BW733_02520	COG0488	(ABC) transporter
BW733_02525	COG2066	Belongs to the glutaminase family
BW733_02535	COG0656	L-ascorbic acid biosynthetic process
BW733_02550	COG1823	symporter activity
BW733_02555	COG0174	glutamine synthetase
BW733_02560	COG2409	Drug exporters of the RND superfamily
BW733_02565	COG0604	alcohol dehydrogenase
BW733_02585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BW733_02590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BW733_02595	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BW733_02605	COG0174	glutamine synthetase
BW733_02650	COG2801	Transposase and inactivated derivatives
BW733_02705	COG0557	exoribonuclease II activity
BW733_02715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW733_02720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BW733_02725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BW733_02745	COG3304	Inner membrane component domain
BW733_02750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BW733_02755	COG0101	tRNA pseudouridine synthase activity
BW733_02775	COG2755	lipolytic protein G-D-S-L family
BW733_02775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BW733_02785	COG0438	transferase activity, transferring glycosyl groups
BW733_02805	COG1609	Transcriptional regulator
BW733_02815	COG4120	Belongs to the binding-protein-dependent transport system permease family
BW733_02830	COG0203	ribosomal protein L17
BW733_02835	COG0202	RNA polymerase activity
BW733_02840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BW733_02845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BW733_02850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BW733_02855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BW733_02865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BW733_02875	COG2801	Transposase and inactivated derivatives
BW733_02885	COG3459	Glycosyltransferase 36 associated
BW733_02900	COG1175	transmembrane transport
BW733_02905	COG0395	ABC-type sugar transport system, permease component
BW733_02935	COG0024	Methionine aminopeptidase
BW733_02940	COG0563	adenylate kinase activity
BW733_02955	COG1841	ribosomal large subunit assembly
BW733_02960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BW733_02965	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BW733_02970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BW733_02975	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BW733_02980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BW733_02985	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BW733_02990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BW733_02995	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BW733_03005	COG1950	PFAM Membrane protein of
BW733_03015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BW733_03020	COG0255	Belongs to the universal ribosomal protein uL29 family
BW733_03025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BW733_03030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BW733_03035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BW733_03040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BW733_03045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BW733_03050	COG0089	rRNA binding
BW733_03055	COG0088	Forms part of the polypeptide exit tunnel
BW733_03060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BW733_03065	COG0051	transcription antitermination factor activity, RNA binding
BW733_03075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BW733_03090	COG3209	COG3209 Rhs family protein
BW733_03110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BW733_03120	COG1051	belongs to the nudix hydrolase family
BW733_03145	COG0435	Glutathione S-transferase
BW733_03160	COG2837	iron assimilation
BW733_03165	COG0281	malic enzyme
BW733_03175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW733_03185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW733_03210	COG1879	ABC-type sugar transport system periplasmic component
BW733_03250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BW733_03255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BW733_03260	COG0049	tRNA binding
BW733_03265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BW733_03275	COG2801	Transposase and inactivated derivatives
BW733_03295	COG4974	Belongs to the 'phage' integrase family
BW733_03315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BW733_03320	COG0085	RNA polymerase activity
BW733_03325	COG0222	ribosome binding
BW733_03330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BW733_03335	COG2801	Transposase and inactivated derivatives
BW733_03345	COG0765	amino acid transport
BW733_03360	COG1609	Transcriptional regulator
BW733_03370	COG0081	regulation of translation
BW733_03375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BW733_03380	COG0250	Participates in transcription elongation, termination and antitermination
BW733_03400	COG1132	(ABC) transporter
BW733_03405	COG1132	(ABC) transporter
BW733_03410	COG1473	amidohydrolase
BW733_03415	COG1705	Flagellar rod assembly protein muramidase FlgJ
BW733_03415	COG3942	CHAP domain
BW733_03420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BW733_03430	COG2030	dehydratase
BW733_03440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BW733_03460	COG2801	Transposase and inactivated derivatives
BW733_03470	COG0813	purine-nucleoside phosphorylase activity
BW733_03480	COG1666	GTP binding
BW733_03485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BW733_03505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW733_03515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW733_03520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BW733_03525	COG0674	pyruvate-flavodoxin oxidoreductase activity
BW733_03525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BW733_03530	COG1013	pyruvate-flavodoxin oxidoreductase activity
BW733_03540	COG3590	peptidase
BW733_03555	COG1007	ATP synthesis coupled electron transport
BW733_03570	COG0713	ATP synthesis coupled electron transport
BW733_03580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW733_03590	COG1034	ATP synthesis coupled electron transport
BW733_03595	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BW733_03605	COG0649	NAD binding
BW733_03610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW733_03615	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW733_03625	COG0644	oxidoreductase
BW733_03630	COG1169	isochorismate synthase
BW733_03655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BW733_03660	COG0484	heat shock protein binding
BW733_03675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BW733_03680	COG2226	methyltransferase
BW733_03690	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BW733_03695	COG4948	Mandelate Racemase Muconate Lactonizing
BW733_03715	COG1461	Dihydroxyacetone kinase
BW733_03720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BW733_03745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BW733_03775	COG1082	Xylose isomerase domain protein TIM barrel
BW733_03790	COG1129	ABC transporter
BW733_03795	COG1879	ABC-type sugar transport system periplasmic component
BW733_03800	COG1349	DNA-binding transcription factor activity
BW733_03815	COG2066	Belongs to the glutaminase family
BW733_03815	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BW733_03825	COG1070	Carbohydrate kinase
BW733_03830	COG1609	Transcriptional regulator
BW733_03870	COG1794	racemase activity, acting on amino acids and derivatives
BW733_03895	COG3040	lipid binding
BW733_03965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW733_03990	COG2838	Isocitrate dehydrogenase
BW733_04010	COG0442	prolyl-tRNA aminoacylation
BW733_04015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BW733_04035	COG0577	efflux transmembrane transporter activity
BW733_04035	COG1136	(ABC) transporter
BW733_04040	COG0577	efflux transmembrane transporter activity
BW733_04040	COG1136	(ABC) transporter
BW733_04055	COG1757	Na H antiporter
BW733_04060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BW733_04090	COG0521	Mo-molybdopterin cofactor biosynthetic process
BW733_04090	COG0315	cyclic pyranopterin monophosphate synthase activity
BW733_04095	COG0315	cyclic pyranopterin monophosphate synthase activity
BW733_04110	COG0314	molybdopterin synthase activity
BW733_04130	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BW733_04135	COG1140	nitrate reductase beta subunit
BW733_04145	COG0746	molybdenum cofactor guanylyltransferase activity
BW733_04155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BW733_04165	COG3833	ABC-type maltose transport systems, permease component
BW733_04170	COG1175	transmembrane transport
BW733_04180	COG1609	Transcriptional regulator
BW733_04185	COG1126	abc transporter atp-binding protein
BW733_04190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW733_04195	COG0765	amino acid transport
BW733_04200	COG0765	amino acid transport
BW733_04205	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BW733_04210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BW733_04235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BW733_04245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW733_04270	COG1846	Transcriptional regulator
BW733_04275	COG0697	spore germination
BW733_04315	COG0151	Belongs to the GarS family
BW733_04340	COG2318	DinB family
BW733_04345	COG2801	Transposase and inactivated derivatives
BW733_04345	COG3415	Transposase
BW733_04355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BW733_04380	COG2376	Dihydroxyacetone kinase
BW733_04385	COG1461	Dihydroxyacetone kinase
BW733_04430	COG1653	transport
BW733_04435	COG1609	Transcriptional regulator
BW733_04470	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BW733_04480	COG3485	protocatechuate 3,4-dioxygenase
BW733_04485	COG1490	D-aminoacyl-tRNA deacylase activity
BW733_04495	COG0745	RESPONSE REGULATOR receiver
BW733_04500	COG0456	acetyltransferase
BW733_04505	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BW733_04530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BW733_04540	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_04550	COG1472	Belongs to the glycosyl hydrolase 3 family
BW733_04560	COG0300	oxidoreductase activity
BW733_04570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BW733_04580	COG0785	Cytochrome C biogenesis protein
BW733_04590	COG0406	alpha-ribazole phosphatase activity
BW733_04610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW733_04630	COG1082	Xylose isomerase domain protein TIM barrel
BW733_04640	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BW733_04655	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BW733_04660	COG4143	(ABC) transporter
BW733_04670	COG3842	ATPase activity
BW733_04675	COG0477	Major facilitator Superfamily
BW733_04690	COG1213	nucleotidyl transferase
BW733_04690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BW733_04695	COG2149	membrane
BW733_04705	COG0542	response to heat
BW733_04715	COG0649	NAD binding
BW733_04735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BW733_04745	COG0302	gtp cyclohydrolase
BW733_04765	COG0037	tRNA processing
BW733_04775	COG2027	D-alanyl-D-alanine carboxypeptidase
BW733_04780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BW733_04785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BW733_04790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BW733_04840	COG1774	PSP1 C-terminal conserved region
BW733_04850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BW733_04855	COG0730	response to heat
BW733_04860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BW733_04870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BW733_04870	COG1754	DNA topoisomerase type I activity
BW733_04890	COG1695	Transcriptional regulator
BW733_04895	COG3214	Protein conserved in bacteria
BW733_04910	COG0667	Aldo Keto reductase
BW733_04930	COG1111	helicase
BW733_04930	COG1205	dead DEAH box helicase
BW733_04975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW733_04980	COG0494	nUDIX hydrolase
BW733_04990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW733_05045	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BW733_05095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BW733_05100	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
BW733_05105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BW733_05110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BW733_05135	COG2801	Transposase and inactivated derivatives
BW733_05170	COG4974	Belongs to the 'phage' integrase family
BW733_05210	COG0791	NLP P60 protein
BW733_05210	COG3883	PFAM NLP P60 protein
BW733_05275	COG3344	reverse transcriptase
BW733_05290	COG4974	Belongs to the 'phage' integrase family
BW733_05295	COG0582	viral genome integration into host DNA
BW733_05300	COG0582	viral genome integration into host DNA
BW733_05345	COG2197	response regulator
BW733_05355	COG1136	(ABC) transporter
BW733_05390	COG1349	DNA-binding transcription factor activity
BW733_05405	COG2813	Specifically methylates the guanine in position
BW733_05420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW733_05425	COG0560	Phosphoserine phosphatase
BW733_05430	COG0406	alpha-ribazole phosphatase activity
BW733_05440	COG2095	MarC family integral membrane protein
BW733_05450	COG0277	FAD linked oxidase domain protein
BW733_05475	COG2357	RelA SpoT domain protein
BW733_05490	COG3655	Transcriptional regulator
BW733_05500	COG1473	amidohydrolase
BW733_05505	COG1803	Methylglyoxal synthase
BW733_05525	COG0693	protein deglycase activity
BW733_05550	COG1285	pathogenesis
BW733_05555	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BW733_05560	COG0352	thiamine-phosphate diphosphorylase activity
BW733_05560	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BW733_05560	COG0351	phosphomethylpyrimidine kinase
BW733_05565	COG0351	phosphomethylpyrimidine kinase
BW733_05570	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BW733_05570	COG0351	phosphomethylpyrimidine kinase
BW733_05570	COG0352	thiamine-phosphate diphosphorylase activity
BW733_05580	COG0058	SHG alpha-glucan phosphorylase activity
BW733_05620	COG0789	Transcriptional regulator
BW733_05625	COG0484	heat shock protein binding
BW733_05630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BW733_05650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BW733_05670	COG1252	NADH dehydrogenase
BW733_05680	COG0745	RESPONSE REGULATOR receiver
BW733_05685	COG2205	protein histidine kinase activity
BW733_05695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BW733_05700	COG1132	(ABC) transporter
BW733_05705	COG0717	Belongs to the dCTP deaminase family
BW733_05725	COG0714	Associated with various cellular activities
BW733_05740	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BW733_05750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BW733_05780	COG3132	Protein of unknown function, DUF480
BW733_05795	COG0433	COG0433 Predicted ATPase
BW733_05820	COG2801	Transposase and inactivated derivatives
BW733_05830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BW733_05845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BW733_05910	COG2015	COG2015, Alkyl sulfatase and related hydrolases
BW733_05925	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BW733_05930	COG0584	glycerophosphoryl diester phosphodiesterase
BW733_05940	COG2801	Transposase and inactivated derivatives
BW733_05945	COG2801	Transposase and inactivated derivatives
BW733_05970	COG1201	RNA secondary structure unwinding
BW733_05975	COG2801	Transposase and inactivated derivatives
BW733_05975	COG3415	Transposase
BW733_05995	COG1196	nuclear chromosome segregation
BW733_06025	COG1175	transmembrane transport
BW733_06030	COG0395	ABC-type sugar transport system, permease component
BW733_06040	COG0383	alpha-mannosidase activity
BW733_06055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BW733_06075	COG1316	TRANSCRIPTIONal
BW733_06090	COG0564	pseudouridine synthase activity
BW733_06135	COG1131	(ABC) transporter
BW733_06140	COG0842	Transport permease protein
BW733_06145	COG4585	Histidine kinase
BW733_06150	COG2197	response regulator
BW733_06155	COG0477	Major facilitator Superfamily
BW733_06210	COG0137	argininosuccinate synthase activity
BW733_06270	COG0438	transferase activity, transferring glycosyl groups
BW733_06275	COG0438	transferase activity, transferring glycosyl groups
BW733_06285	COG0438	transferase activity, transferring glycosyl groups
BW733_06300	COG1134	teichoic acid transport
BW733_06310	COG0561	phosphatase activity
BW733_06315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BW733_06320	COG2814	Major facilitator Superfamily
BW733_06330	COG1597	lipid kinase activity
BW733_06345	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BW733_06350	COG0582	viral genome integration into host DNA
BW733_06360	COG4974	Belongs to the 'phage' integrase family
BW733_06370	COG3344	reverse transcriptase
BW733_06385	COG1404	Belongs to the peptidase S8 family
BW733_06390	COG1674	ftsk spoiiie
BW733_06435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW733_06440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BW733_06450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BW733_06460	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW733_06465	COG0022	dehydrogenase e1 component
BW733_06475	COG0737	Belongs to the 5'-nucleotidase family
BW733_06480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BW733_06485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BW733_06520	COG1595	DNA-templated transcription, initiation
BW733_06565	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BW733_06570	COG2124	cytochrome p450
BW733_06585	COG0517	IMP dehydrogenase activity
BW733_06595	COG0411	ABC transporter
BW733_06605	COG0559	Belongs to the binding-protein-dependent transport system permease family
BW733_06625	COG2390	Transcriptional regulator
BW733_06630	COG1064	alcohol dehydrogenase
BW733_06640	COG1309	transcriptional regulator
BW733_06655	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_06680	COG0028	Belongs to the TPP enzyme family
BW733_06685	COG0640	Transcriptional regulator
BW733_06695	COG2329	Antibiotic biosynthesis monooxygenase
BW733_06705	COG1846	Transcriptional regulator
BW733_06715	COG1760	l-serine dehydratase
BW733_06720	COG2197	response regulator
BW733_06745	COG1090	epimerase
BW733_06750	COG0501	Belongs to the peptidase M48B family
BW733_06755	COG0359	binds to the 23S rRNA
BW733_06760	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BW733_06770	COG0360	Binds together with S18 to 16S ribosomal RNA
BW733_06795	COG1022	Amp-dependent synthetase and ligase
BW733_06800	COG0488	(ABC) transporter
BW733_06805	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BW733_06830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BW733_06835	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BW733_06840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BW733_06840	COG2111	Na H antiporter
BW733_06855	COG1863	multisubunit Na H antiporter MnhE subunit
BW733_06865	COG1320	monovalent cation:proton antiporter activity
BW733_06870	COG2154	pterin-4-alpha-carbinolamine dehydratase
BW733_06900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW733_06930	COG4221	oxidoreductase activity
BW733_06965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BW733_06965	COG0574	Belongs to the PEP-utilizing enzyme family
BW733_06970	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BW733_07015	COG4214	carbohydrate transport
BW733_07035	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BW733_07065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BW733_07070	COG2318	DinB family
BW733_07085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW733_07100	COG1733	regulation of RNA biosynthetic process
BW733_07105	COG0668	transmembrane transport
BW733_07110	COG0617	tRNA 3'-terminal CCA addition
BW733_07130	COG0477	Major facilitator Superfamily
BW733_07195	COG1793	dna ligase
BW733_07210	COG1129	ABC transporter
BW733_07220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BW733_07225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BW733_07305	COG2409	Drug exporters of the RND superfamily
BW733_07325	COG3851	Histidine kinase
BW733_07330	COG2197	response regulator
BW733_07340	COG0861	Integral membrane protein TerC family
BW733_07365	COG1131	(ABC) transporter
BW733_07375	COG0842	Transport permease protein
BW733_07390	COG2076	Multidrug Resistance protein
BW733_07400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW733_07430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BW733_07450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BW733_07455	COG2354	Protein conserved in bacteria
BW733_07510	COG1518	maintenance of DNA repeat elements
BW733_07555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BW733_07615	COG2801	Transposase and inactivated derivatives
BW733_07635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW733_07680	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
BW733_07685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BW733_07690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BW733_07695	COG0592	DNA-directed DNA polymerase activity
BW733_07705	COG1136	(ABC) transporter
BW733_07740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BW733_07745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BW733_07750	COG0594	ribonuclease P activity
BW733_07755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BW733_07760	COG0706	membrane insertase activity
BW733_07770	COG0357	Ribosomal RNA small subunit methyltransferase G
BW733_07775	COG1733	regulation of RNA biosynthetic process
BW733_07780	COG1484	DNA-dependent DNA replication
BW733_07810	COG1192	Involved in chromosome partitioning
BW733_07815	COG1475	DNA binding
BW733_07830	COG1181	Belongs to the D-alanine--D-alanine ligase family
BW733_07845	COG3118	belongs to the thioredoxin family
BW733_07855	COG1024	Enoyl-CoA hydratase
BW733_07865	COG2390	Transcriptional regulator
BW733_07870	COG1335	isochorismatase
BW733_07880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BW733_07995	COG3415	Transposase
BW733_07995	COG2801	Transposase and inactivated derivatives
BW733_08020	COG3119	arylsulfatase activity
BW733_08030	COG0395	ABC-type sugar transport system, permease component
BW733_08035	COG4209	transmembrane transport
BW733_08045	COG3119	arylsulfatase activity
BW733_08050	COG5434	Belongs to the glycosyl hydrolase 28 family
BW733_08065	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BW733_08075	COG0673	inositol 2-dehydrogenase activity
BW733_08090	COG4974	Belongs to the 'phage' integrase family
BW733_08110	COG4974	Belongs to the 'phage' integrase family
BW733_08180	COG4585	Histidine kinase
BW733_08185	COG2197	response regulator
BW733_08270	COG0673	inositol 2-dehydrogenase activity
BW733_08275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BW733_08295	COG3718	enzyme involved in inositol metabolism
BW733_08300	COG3962	Belongs to the TPP enzyme family
BW733_08305	COG1082	Xylose isomerase domain protein TIM barrel
BW733_08310	COG1879	ABC-type sugar transport system periplasmic component
BW733_08315	COG1129	ABC transporter
BW733_08320	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW733_08325	COG0673	inositol 2-dehydrogenase activity
BW733_08330	COG1082	Xylose isomerase domain protein TIM barrel
BW733_08335	COG0673	inositol 2-dehydrogenase activity
BW733_08360	COG4585	Histidine kinase
BW733_08365	COG2197	response regulator
BW733_08390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BW733_08400	COG1940	carbohydrate kinase activity
BW733_08405	COG2115	Belongs to the xylose isomerase family
BW733_08420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BW733_08520	COG0705	Rhomboid family
BW733_08520	COG0457	Tetratricopeptide repeat
BW733_08625	COG0640	Transcriptional regulator
BW733_08640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW733_08645	COG4974	Belongs to the 'phage' integrase family
BW733_08650	COG0582	viral genome integration into host DNA
BW733_08655	COG0582	viral genome integration into host DNA
BW733_08670	COG1132	(ABC) transporter
BW733_08710	COG1660	Displays ATPase and GTPase activities
BW733_08755	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BW733_08780	COG0456	acetyltransferase
BW733_08785	COG1278	Cold shock
BW733_08795	COG4106	trans-aconitate 2-methyltransferase activity
BW733_08840	COG1764	response to oxidative stress
BW733_08850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BW733_08855	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BW733_08865	COG0419	ATPase involved in DNA repair
BW733_08870	COG0420	3'-5' exonuclease activity
BW733_08885	COG2197	response regulator
BW733_08890	COG2340	Cysteine-rich secretory protein family
BW733_08965	COG4172	Belongs to the ABC transporter superfamily
BW733_08995	COG4941	Belongs to the sigma-70 factor family
BW733_09015	COG0513	Belongs to the DEAD box helicase family
BW733_09025	COG0823	Involved in the tonB-independent uptake of proteins
BW733_09025	COG1506	peptidase
BW733_09055	COG4941	Belongs to the sigma-70 factor family
BW733_09060	COG2801	Transposase and inactivated derivatives
BW733_09080	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BW733_09100	COG3655	Transcriptional regulator
BW733_09145	COG3336	cytochrome c oxidase
BW733_09175	COG1609	Transcriptional regulator
BW733_09250	COG1064	alcohol dehydrogenase
BW733_09260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BW733_09265	COG1253	flavin adenine dinucleotide binding
BW733_09280	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BW733_09295	COG0318	PFAM AMP-dependent synthetase and ligase
BW733_09305	COG2267	carboxylic ester hydrolase activity
BW733_09350	COG1132	(ABC) transporter
BW733_09380	COG0439	Biotin carboxylase
BW733_09385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BW733_09405	COG2205	protein histidine kinase activity
BW733_09410	COG0745	RESPONSE REGULATOR receiver
BW733_09450	COG2066	Belongs to the glutaminase family
BW733_09450	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BW733_09480	COG1012	belongs to the aldehyde dehydrogenase family
BW733_09535	COG4608	Belongs to the ABC transporter superfamily
BW733_09565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW733_09575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW733_09585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW733_09620	COG1597	lipid kinase activity
BW733_09670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW733_09675	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW733_09690	COG1393	Belongs to the ArsC family
BW733_09705	COG0686	Belongs to the AlaDH PNT family
BW733_09715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW733_09720	COG1397	ADP-ribosylglycohydrolase
BW733_09740	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BW733_09750	COG1742	UPF0060 membrane protein
BW733_09765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BW733_09770	COG1309	transcriptional regulator
BW733_09795	COG0305	Participates in initiation and elongation during chromosome replication
BW733_09800	COG1937	Protein conserved in bacteria
BW733_09810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BW733_09815	COG0114	fumarate hydratase activity
BW733_09845	COG1929	Belongs to the glycerate kinase type-1 family
BW733_09850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BW733_09855	COG4988	ABC transporter
BW733_09860	COG1294	oxidase, subunit
BW733_09865	COG1271	oxidase subunit
BW733_09875	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BW733_09880	COG2326	polyphosphate kinase activity
BW733_09885	COG2514	catechol 2,3-dioxygenase activity
BW733_09920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BW733_09930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BW733_09950	COG0515	serine threonine protein kinase
BW733_09955	COG0768	penicillin binding
BW733_09975	COG1716	ATPase activity
BW733_09985	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BW733_09990	COG1609	Transcriptional regulator
BW733_10030	COG3344	reverse transcriptase
BW733_10040	COG4974	Belongs to the 'phage' integrase family
BW733_10055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BW733_10070	COG1070	Carbohydrate kinase
BW733_10075	COG0406	alpha-ribazole phosphatase activity
BW733_10080	COG0438	transferase activity, transferring glycosyl groups
BW733_10090	COG2610	gluconate transmembrane transporter activity
BW733_10095	COG3265	gluconokinase activity
BW733_10115	COG3458	cephalosporin-C deacetylase activity
BW733_10120	COG2186	Transcriptional regulator
BW733_10125	COG0747	negative chemotaxis
BW733_10135	COG0444	Belongs to the ABC transporter superfamily
BW733_10145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BW733_10150	COG1940	carbohydrate kinase activity
BW733_10155	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BW733_10180	COG0166	Belongs to the GPI family
BW733_10190	COG2226	methyltransferase
BW733_10210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BW733_10230	COG0018	arginyl-trna synthetase
BW733_10235	COG1940	carbohydrate kinase activity
BW733_10255	COG0205	6-phosphofructokinase activity
BW733_10275	COG0277	FAD linked oxidase domain protein
BW733_10325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BW733_10335	COG2326	polyphosphate kinase activity
BW733_10340	COG0546	phosphoglycolate phosphatase activity
BW733_10350	COG1464	Belongs to the NlpA lipoprotein family
BW733_10355	COG2011	ABC-type metal ion transport system permease component
BW733_10360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BW733_10365	COG2267	carboxylic ester hydrolase activity
BW733_10415	COG1793	dna ligase
BW733_10425	COG0156	8-amino-7-oxononanoate synthase activity
BW733_10430	COG1063	alcohol dehydrogenase
BW733_10440	COG1472	Belongs to the glycosyl hydrolase 3 family
BW733_10450	COG0542	response to heat
BW733_10465	COG0259	pyridoxamine-phosphate oxidase activity
BW733_10480	COG2133	pyrroloquinoline quinone binding
BW733_10485	COG0534	Mate efflux family protein
BW733_10490	COG2095	MarC family integral membrane protein
BW733_10510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BW733_10515	COG1704	LemA family
BW733_10535	COG0191	fructose-bisphosphate aldolase activity
BW733_10540	COG2801	Transposase and inactivated derivatives
BW733_10565	COG1937	Protein conserved in bacteria
BW733_10570	COG2217	Heavy metal translocating P-type atpase
BW733_10610	COG2205	protein histidine kinase activity
BW733_10615	COG0745	RESPONSE REGULATOR receiver
BW733_10640	COG2801	Transposase and inactivated derivatives
BW733_10675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BW733_10735	COG1404	Belongs to the peptidase S8 family
BW733_10765	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW733_10775	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
BW733_10780	COG1070	Carbohydrate kinase
BW733_10785	COG1609	Transcriptional regulator
BW733_10795	COG4213	ABC transporter substrate-binding protein
BW733_10800	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW733_10805	COG1129	ABC transporter
BW733_10815	COG1129	ABC transporter
BW733_10825	COG1595	DNA-templated transcription, initiation
BW733_10845	COG1595	DNA-templated transcription, initiation
BW733_10880	COG1349	DNA-binding transcription factor activity
BW733_10885	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW733_10890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW733_10895	COG0022	dehydrogenase e1 component
BW733_10905	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_10910	COG2190	(PTS) system
BW733_10920	COG0494	nUDIX hydrolase
BW733_10955	COG0582	viral genome integration into host DNA
BW733_10965	COG2801	Transposase and inactivated derivatives
BW733_10975	COG4974	Belongs to the 'phage' integrase family
BW733_10980	COG0582	viral genome integration into host DNA
BW733_10985	COG4974	Belongs to the 'phage' integrase family
BW733_11015	COG4974	Belongs to the 'phage' integrase family
BW733_11020	COG0582	viral genome integration into host DNA
BW733_11025	COG0582	viral genome integration into host DNA
BW733_11075	COG0588	phosphoglycerate mutase activity
BW733_11080	COG0726	polysaccharide deacetylase
BW733_11090	COG5002	protein histidine kinase activity
BW733_11105	COG1329	Transcriptional regulator
BW733_11110	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BW733_11115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BW733_11125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BW733_11135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BW733_11140	COG0215	cysteine-tRNA ligase activity
BW733_11160	COG0789	Transcriptional regulator
BW733_11180	COG0626	cystathionine gamma-synthase activity
BW733_11185	COG3842	ATPase activity
BW733_11240	COG0459	protein refolding
BW733_11255	COG4133	protoheme IX ABC transporter activity
BW733_11300	COG0494	nUDIX hydrolase
BW733_11310	COG0363	glucosamine-6-phosphate deaminase activity
BW733_11315	COG1278	Cold shock
BW733_11330	COG2252	PERMEase
BW733_11335	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BW733_11350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BW733_11365	COG1321	iron dependent repressor
BW733_11370	COG2226	methyltransferase
BW733_11380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW733_11385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BW733_11385	COG0493	'glutamate synthase
BW733_11395	COG0167	dihydroorotate dehydrogenase activity
BW733_11440	COG2801	Transposase and inactivated derivatives
BW733_11460	COG2132	Multicopper oxidase
BW733_11480	COG1970	mechanosensitive ion channel activity
BW733_11550	COG0138	bifunctional purine biosynthesis protein purh
BW733_11555	COG1309	transcriptional regulator
BW733_11610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BW733_11630	COG2217	Heavy metal translocating P-type atpase
BW733_11665	COG2233	PERMEase
BW733_11670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BW733_11670	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BW733_11690	COG0084	hydrolase, TatD family'
BW733_11695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BW733_11700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BW733_11705	COG1846	Transcriptional regulator
BW733_11720	COG2818	Glycosylase
BW733_11740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BW733_11745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BW733_11760	COG1136	(ABC) transporter
BW733_11780	COG0477	Major facilitator Superfamily
BW733_11785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW733_11790	COG3415	Transposase
BW733_11790	COG2801	Transposase and inactivated derivatives
BW733_11800	COG1609	Transcriptional regulator
BW733_11825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BW733_11830	COG0193	aminoacyl-tRNA hydrolase activity
BW733_11850	COG3956	TIGRFAM MazG family protein
BW733_11855	COG0148	phosphopyruvate hydratase activity
BW733_11885	COG2801	Transposase and inactivated derivatives
BW733_11895	COG1780	Probably involved in ribonucleotide reductase function
BW733_11900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW733_11905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW733_11940	COG2268	Band 7 protein
BW733_12015	COG2321	neutral zinc metallopeptidase
BW733_12035	COG1254	Belongs to the acylphosphatase family
BW733_12050	COG0582	viral genome integration into host DNA
BW733_12090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BW733_12105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BW733_12115	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW733_12125	COG1331	Highly conserved protein containing a thioredoxin domain
BW733_12150	COG0582	viral genome integration into host DNA
BW733_12165	COG1793	dna ligase
BW733_12210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BW733_12225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BW733_12235	COG1722	exodeoxyribonuclease VII activity
BW733_12240	COG1570	exodeoxyribonuclease VII activity
BW733_12245	COG0561	phosphatase activity
BW733_12255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BW733_12270	COG1322	Protein conserved in bacteria
BW733_12285	COG1362	aminopeptidase activity
BW733_12290	COG3415	Transposase
BW733_12290	COG2801	Transposase and inactivated derivatives
BW733_12320	COG0012	GTP binding
BW733_12375	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BW733_12390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW733_12400	COG0019	diaminopimelate decarboxylase activity
BW733_12405	COG1902	pentaerythritol trinitrate reductase activity
BW733_12425	COG0534	Mate efflux family protein
BW733_12445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BW733_12455	COG2801	Transposase and inactivated derivatives
BW733_12480	COG0582	viral genome integration into host DNA
BW733_12485	COG2226	methyltransferase
BW733_12515	COG1192	Involved in chromosome partitioning
BW733_12540	COG1132	(ABC) transporter
BW733_12590	COG1045	serine acetyltransferase
BW733_12625	COG1335	isochorismatase
BW733_12640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW733_12655	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BW733_12670	COG0616	signal peptide processing
BW733_12700	COG2171	N-acyltransferase activity
BW733_12745	COG1305	Transglutaminase-like
BW733_12750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW733_12755	COG1611	Belongs to the LOG family
BW733_12770	COG0297	glycogen (starch) synthase activity
BW733_12775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BW733_12800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BW733_12805	COG1595	DNA-templated transcription, initiation
BW733_12815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BW733_12820	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BW733_12845	COG2239	Acts as a magnesium transporter
BW733_12855	COG2264	protein methyltransferase activity
BW733_12865	COG0006	proline dipeptidase activity
BW733_12870	COG2860	membrane
BW733_12875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BW733_12880	COG1072	(Pantothenic acid kinase))
BW733_12885	COG0736	holo-[acyl-carrier-protein] synthase activity
BW733_12900	COG2801	Transposase and inactivated derivatives
BW733_12905	COG0513	Belongs to the DEAD box helicase family
BW733_12910	COG0802	atpase or kinase
BW733_12925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BW733_12930	COG0747	negative chemotaxis
BW733_12935	COG0601	transmembrane transport
BW733_12940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW733_12945	COG4172	Belongs to the ABC transporter superfamily
BW733_12975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BW733_12995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BW733_13000	COG0459	protein refolding
BW733_13005	COG0210	DNA helicase
BW733_13015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW733_13050	COG0516	GMP reductase activity
BW733_13055	COG1605	Chorismate mutase
BW733_13055	COG0287	Prephenate dehydrogenase
BW733_13070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW733_13080	COG1131	(ABC) transporter
BW733_13100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BW733_13100	COG0519	Catalyzes the synthesis of GMP from XMP
BW733_13125	COG2197	response regulator
BW733_13155	COG0045	succinate-CoA ligase (ADP-forming) activity
BW733_13180	COG0138	bifunctional purine biosynthesis protein purh
BW733_13185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BW733_13200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW733_13210	COG0395	ABC-type sugar transport system, permease component
BW733_13215	COG1175	transmembrane transport
BW733_13230	COG1486	melibiose metabolic process
BW733_13245	COG0039	L-malate dehydrogenase activity
BW733_13250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BW733_13260	COG1253	flavin adenine dinucleotide binding
BW733_13295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BW733_13305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW733_13330	COG0024	Methionine aminopeptidase
BW733_13335	COG3012	SEC-C Motif Domain Protein
BW733_13375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW733_13400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW733_13415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BW733_13430	COG4770	biotin carboxylase activity
BW733_13450	COG1595	DNA-templated transcription, initiation
BW733_13465	COG0424	maF-like protein
BW733_13475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BW733_13505	COG1316	TRANSCRIPTIONal
BW733_13510	COG1316	TRANSCRIPTIONal
BW733_13535	COG0662	Cupin 2, conserved barrel domain protein
BW733_13535	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BW733_13575	COG2835	tetraacyldisaccharide 4'-kinase activity
BW733_13585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BW733_13600	COG2814	Major facilitator Superfamily
BW733_13605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BW733_13605	COG0515	serine threonine protein kinase
BW733_13655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BW733_13665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BW733_13670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BW733_13675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BW733_13680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BW733_13690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BW733_13700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BW733_13755	COG1739	Uncharacterized protein family UPF0029
BW733_13775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW733_13785	COG2801	Transposase and inactivated derivatives
BW733_13795	COG2801	Transposase and inactivated derivatives
BW733_13815	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BW733_13860	COG0582	viral genome integration into host DNA
BW733_13905	COG1192	Involved in chromosome partitioning
BW733_13980	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BW733_14000	COG1595	DNA-templated transcription, initiation
BW733_14005	COG0277	FAD linked oxidase domain protein
BW733_14025	COG1129	ABC transporter
BW733_14035	COG2885	chlorophyll binding
BW733_14050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW733_14055	COG1201	RNA secondary structure unwinding
BW733_14060	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BW733_14065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BW733_14070	COG0540	Belongs to the ATCase OTCase family
BW733_14075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BW733_14085	COG2814	Major facilitator Superfamily
BW733_14095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BW733_14100	COG0698	ribose 5-phosphate isomerase
BW733_14145	COG1403	HNH endonuclease
BW733_14165	COG0544	peptidyl-prolyl cis-trans isomerase activity
BW733_14170	COG0628	permease
BW733_14175	COG0740	serine-type endopeptidase activity
BW733_14180	COG0740	serine-type endopeptidase activity
BW733_14185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BW733_14190	COG4946	Tricorn protease homolog
BW733_14190	COG0793	Belongs to the peptidase S41A family
BW733_14195	COG0525	valine-tRNA ligase activity
BW733_14215	COG0285	dihydrofolate synthase activity
BW733_14225	COG0105	UTP biosynthetic process
BW733_14255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BW733_14260	COG0596	Alpha beta hydrolase
BW733_14260	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW733_14265	COG4868	Belongs to the UPF0371 family
BW733_14270	COG2807	transmembrane transport
BW733_14280	COG1530	ribonuclease E activity
BW733_14285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BW733_14290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BW733_14295	COG0742	ribosomal rna small subunit methyltransferase
BW733_14305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BW733_14320	COG2801	Transposase and inactivated derivatives
BW733_14335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BW733_14340	COG0571	ribonuclease III activity
BW733_14345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW733_14385	COG0514	ATP-dependent DNA helicase (RecQ)
BW733_14415	COG0228	four-way junction DNA binding
BW733_14420	COG1837	Belongs to the UPF0109 family
BW733_14425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BW733_14430	COG0336	Belongs to the RNA methyltransferase TrmD family
BW733_14440	COG1053	succinate dehydrogenase
BW733_14445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BW733_14450	COG2801	Transposase and inactivated derivatives
BW733_14455	COG1484	DNA-dependent DNA replication
BW733_14470	COG0335	large ribosomal subunit rRNA binding
BW733_14485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BW733_14495	COG0792	nuclease activity
BW733_14500	COG0606	chelatase, subunit chli
BW733_14525	COG3845	ABC transporter
BW733_14590	COG1595	DNA-templated transcription, initiation
BW733_14595	COG3328	transposase activity
BW733_14610	COG0577	efflux transmembrane transporter activity
BW733_14610	COG1136	(ABC) transporter
BW733_14620	COG1136	(ABC) transporter
BW733_14645	COG2197	response regulator
BW733_14650	COG4585	Histidine kinase
BW733_14670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BW733_14735	COG0667	Aldo Keto reductase
BW733_14740	COG1968	undecaprenyl-diphosphatase activity
BW733_14745	COG0588	phosphoglycerate mutase activity
BW733_14760	COG0215	cysteine-tRNA ligase activity
BW733_14765	COG0140	phosphoribosyl-ATP diphosphatase activity
BW733_14770	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BW733_14785	COG2801	Transposase and inactivated derivatives
BW733_14785	COG3415	Transposase
BW733_14795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BW733_14800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BW733_14805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BW733_14815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BW733_14820	COG0072	phenylalanine-tRNA ligase activity
BW733_14820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW733_14870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BW733_14875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BW733_14880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BW733_14885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BW733_14895	COG0165	Argininosuccinate lyase
BW733_14900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BW733_14905	COG2801	Transposase and inactivated derivatives
BW733_14910	COG2801	Transposase and inactivated derivatives
BW733_14955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BW733_14960	COG0497	DNA recombination
BW733_14965	COG0504	CTP synthase activity
BW733_14975	COG4974	Belongs to the 'phage' integrase family
BW733_15000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BW733_15010	COG0545	Peptidyl-prolyl cis-trans isomerase
BW733_15015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW733_15020	COG2378	regulation of single-species biofilm formation
BW733_15035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BW733_15040	COG0805	protein transport
BW733_15050	COG4581	dead DEAH box helicase
BW733_15055	COG0107	imidazoleglycerol-phosphate synthase activity
BW733_15060	COG0537	adenosine 5'-monophosphoramidase activity
BW733_15075	COG0440	acetolactate synthase activity
BW733_15080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BW733_15095	COG1063	alcohol dehydrogenase
BW733_15100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BW733_15105	COG1349	DNA-binding transcription factor activity
BW733_15130	COG0473	3-isopropylmalate dehydrogenase activity
BW733_15135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BW733_15140	COG0179	Fumarylacetoacetate (FAA) hydrolase
BW733_15145	COG1266	CAAX protease self-immunity
BW733_15170	COG1414	Transcriptional regulator
BW733_15175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BW733_15180	COG0066	3-isopropylmalate dehydratase activity
BW733_15190	COG1505	serine-type exopeptidase activity
BW733_15195	COG1396	sequence-specific DNA binding
BW733_15200	COG0740	serine-type endopeptidase activity
BW733_15205	COG0740	serine-type endopeptidase activity
BW733_15215	COG0204	Acyl-transferase
BW733_15220	COG1181	Belongs to the D-alanine--D-alanine ligase family
BW733_15240	COG1674	ftsk spoiiie
BW733_15245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW733_15255	COG1058	Belongs to the CinA family
BW733_15255	COG1546	Belongs to the CinA family
BW733_15260	COG1396	sequence-specific DNA binding
BW733_15280	COG2137	regulation of response to DNA damage stimulus
BW733_15285	COG1418	mRNA catabolic process
BW733_15290	COG2017	converts alpha-aldose to the beta-anomer
BW733_15300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW733_15325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BW733_15330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BW733_15335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BW733_15345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BW733_15355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BW733_15360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW733_15370	COG4974	Belongs to the 'phage' integrase family
BW733_15375	COG0582	viral genome integration into host DNA
BW733_15380	COG0582	viral genome integration into host DNA
BW733_15385	COG3328	transposase activity
BW733_15430	COG5426	von Willebrand factor, type A
BW733_15440	COG0129	dihydroxy-acid dehydratase activity
BW733_15445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW733_15450	COG0598	Magnesium transport protein CorA
BW733_15460	COG1492	cobalamin metabolic process
BW733_15465	COG1492	cobalamin metabolic process
BW733_15470	COG4989	oxidoreductase activity
BW733_15485	COG0535	radical SAM domain protein
BW733_15510	COG1643	Atp-dependent helicase
BW733_15515	COG1946	Acyl-CoA thioesterase
BW733_15525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BW733_15535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BW733_15535	COG0519	Catalyzes the synthesis of GMP from XMP
BW733_15540	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BW733_15555	COG1074	ATP-dependent DNA helicase activity
BW733_15560	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BW733_15590	COG1615	UPF0182 protein
BW733_15610	COG0667	Aldo Keto reductase
BW733_15620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW733_15655	COG1609	Transcriptional regulator
BW733_15660	COG4129	membrane
BW733_15675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW733_15680	COG0444	Belongs to the ABC transporter superfamily
BW733_15685	COG4608	Belongs to the ABC transporter superfamily
BW733_15695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BW733_15700	COG0483	inositol monophosphate 1-phosphatase activity
BW733_15715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BW733_15725	COG2135	peptidase activity
BW733_15730	COG1595	DNA-templated transcription, initiation
BW733_15755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BW733_15760	COG0567	Dehydrogenase, E1 component
BW733_15760	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW733_15775	COG0019	diaminopimelate decarboxylase activity
BW733_15780	COG0460	homoserine dehydrogenase
BW733_15785	COG0083	homoserine kinase activity
BW733_15795	COG0254	rRNA binding
BW733_15800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BW733_15805	COG2890	protein-(glutamine-N5) methyltransferase activity
BW733_15810	COG0009	L-threonylcarbamoyladenylate synthase
BW733_15830	COG0356	it plays a direct role in the translocation of protons across the membrane
BW733_15840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BW733_15845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BW733_15850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BW733_15855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BW733_15860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BW733_15865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BW733_15885	COG0194	GDP metabolic process
BW733_15895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BW733_15900	COG0596	Alpha beta hydrolase
BW733_15965	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BW733_15970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BW733_15980	COG0366	Alpha amylase catalytic
BW733_15995	COG0789	Transcriptional regulator
BW733_16000	COG0482	sulfurtransferase activity
BW733_16015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW733_16020	COG0154	amidase activity
BW733_16025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW733_16035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BW733_16065	COG3344	reverse transcriptase
BW733_16075	COG0582	viral genome integration into host DNA
BW733_16080	COG0133	tryptophan synthase activity
BW733_16090	COG2258	MOSC domain
BW733_16095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BW733_16100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BW733_16115	COG0134	indole-3-glycerol-phosphate synthase activity
BW733_16120	COG0133	tryptophan synthase activity
BW733_16140	COG0069	glutamate synthase activity
BW733_16140	COG0067	glutamate synthase
BW733_16140	COG0070	glutamate synthase
BW733_16150	COG0698	ribose 5-phosphate isomerase
BW733_16155	COG0587	DNA-directed DNA polymerase activity
BW733_16165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BW733_16170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BW733_16175	COG0131	Imidazoleglycerol-phosphate dehydratase
BW733_16180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BW733_16185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BW733_16210	COG0217	transcriptional regulatory protein
BW733_16215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BW733_16220	COG0632	four-way junction helicase activity
BW733_16225	COG2255	four-way junction helicase activity
BW733_16230	COG1862	Preprotein translocase
BW733_16235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW733_16240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW733_16245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BW733_16255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BW733_16260	COG1196	nuclear chromosome segregation
BW733_16265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW733_16270	COG0124	histidyl-tRNA synthetase
BW733_16280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BW733_16290	COG2814	Major facilitator Superfamily
BW733_16315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BW733_16320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BW733_16330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BW733_16335	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BW733_16340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BW733_16345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BW733_16370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW733_16375	COG1957	nucleoside hydrolase
BW733_16390	COG2313	pseudouridylate synthase activity
BW733_16395	COG0583	DNA-binding transcription factor activity
BW733_16405	COG1690	Belongs to the RtcB family
BW733_16420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BW733_16425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BW733_16430	COG0505	Belongs to the CarA family
BW733_16435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BW733_16440	COG0167	dihydroorotate dehydrogenase activity
BW733_16445	COG0284	orotidine-5'-phosphate decarboxylase activity
BW733_16455	COG0194	GDP metabolic process
BW733_16460	COG1758	RNA polymerase activity
BW733_16465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BW733_16475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BW733_16500	COG3189	MarR family transcriptional regulator
BW733_16505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BW733_16515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BW733_16525	COG1349	DNA-binding transcription factor activity
BW733_16530	COG0698	ribose 5-phosphate isomerase
BW733_16540	COG0647	UMP catabolic process
BW733_16545	COG1069	ribulokinase activity
BW733_16550	COG0371	Dehydrogenase
BW733_16565	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BW733_16570	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BW733_16580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BW733_16590	COG1160	GTP binding
BW733_16645	COG0542	response to heat
BW733_16675	COG3415	Transposase
BW733_16675	COG2801	Transposase and inactivated derivatives
BW733_16695	COG1175	transmembrane transport
BW733_16700	COG0395	ABC-type sugar transport system, permease component
BW733_16705	COG1621	beta-fructofuranosidase activity
BW733_16710	COG2197	response regulator
BW733_16715	COG4585	Histidine kinase
BW733_16720	COG2409	Drug exporters of the RND superfamily
BW733_16730	COG0545	Peptidyl-prolyl cis-trans isomerase
BW733_16735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW733_16750	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BW733_16755	COG3657	addiction module killer protein
BW733_16790	COG2205	protein histidine kinase activity
BW733_16825	COG0647	UMP catabolic process
BW733_16840	COG1653	transport
BW733_16845	COG1175	transmembrane transport
BW733_16850	COG0395	ABC-type sugar transport system, permease component
BW733_16890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BW733_16895	COG2813	Specifically methylates the guanine in position
BW733_16895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BW733_16900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW733_16910	COG1216	Glycosyl transferase, family 2
BW733_16915	COG3030	protein affecting phage T7 exclusion by the F plasmid
BW733_16930	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BW733_16935	COG1410	methionine synthase
BW733_16935	COG0646	methionine synthase
BW733_16940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BW733_16955	COG0667	Aldo Keto reductase
BW733_16965	COG2190	(PTS) system
BW733_17005	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BW733_17045	COG0537	adenosine 5'-monophosphoramidase activity
BW733_17090	COG0009	L-threonylcarbamoyladenylate synthase
BW733_17115	COG1295	ribonuclease BN
BW733_17135	COG1716	ATPase activity
BW733_17160	COG0438	transferase activity, transferring glycosyl groups
BW733_17175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BW733_17180	COG1024	Enoyl-CoA hydratase
BW733_17185	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_17215	COG1879	ABC-type sugar transport system periplasmic component
BW733_17225	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW733_17235	COG0673	inositol 2-dehydrogenase activity
BW733_17240	COG1940	carbohydrate kinase activity
BW733_17315	COG3547	Transposase (IS116 IS110 IS902 family)
BW733_17360	COG2801	Transposase and inactivated derivatives
BW733_17380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW733_17390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BW733_17395	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BW733_17400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BW733_17410	COG0477	Major facilitator Superfamily
BW733_17415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BW733_17420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BW733_17425	COG0531	amino acid
BW733_17430	COG0569	domain protein
BW733_17455	COG0756	dUTP diphosphatase activity
BW733_17485	COG1435	thymidine kinase activity
BW733_17510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW733_17525	COG1620	l-lactate permease
BW733_17530	COG0247	lactate metabolic process
BW733_17540	COG1556	Lactate utilization protein
BW733_17545	COG0187	DNA topoisomerase II activity
BW733_17570	COG3285	dna ligase
BW733_17570	COG1793	dna ligase
BW733_17590	COG0180	Tryptophanyl-tRNA synthetase
BW733_17595	COG0613	PHP domain protein
BW733_17645	COG1192	Involved in chromosome partitioning
BW733_17670	COG2801	Transposase and inactivated derivatives
BW733_17715	COG0791	NLP P60 protein
BW733_17715	COG3883	PFAM NLP P60 protein
BW733_17750	COG0129	dihydroxy-acid dehydratase activity