locus-tag	class	description
RPIT_00020	COG0730	response to heat
RPIT_00030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RPIT_00030	COG0674	pyruvate-flavodoxin oxidoreductase activity
RPIT_00035	COG1013	pyruvate-flavodoxin oxidoreductase activity
RPIT_00040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RPIT_00040	COG1648	precorrin-2 dehydrogenase activity
RPIT_00045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RPIT_00045	COG1648	precorrin-2 dehydrogenase activity
RPIT_00070	COG0737	Belongs to the 5'-nucleotidase family
RPIT_00085	COG2755	lipolytic protein G-D-S-L family
RPIT_00100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RPIT_00160	COG1793	dna ligase
RPIT_00175	COG1793	dna ligase
RPIT_00200	COG0366	Alpha amylase catalytic
RPIT_00310	COG4044	May play a role in the intracellular transport of hydrophobic ligands
RPIT_00340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RPIT_00345	COG1525	nuclease
RPIT_00345	COG4085	toxin activity
RPIT_00345	COG0737	Belongs to the 5'-nucleotidase family
RPIT_00355	COG0022	dehydrogenase e1 component
RPIT_00360	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIT_00370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RPIT_00380	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RPIT_00385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RPIT_00415	COG0077	Prephenate dehydratase
RPIT_00420	COG1597	lipid kinase activity
RPIT_00425	COG2814	Major facilitator Superfamily
RPIT_00430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RPIT_00435	COG0561	phosphatase activity
RPIT_00440	COG0693	protein deglycase activity
RPIT_00450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIT_00465	COG0137	argininosuccinate synthase activity
RPIT_00485	COG0463	Glycosyl transferase, family 2
RPIT_00485	COG1216	Glycosyl transferase, family 2
RPIT_00495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RPIT_00500	COG2207	Transcriptional regulator
RPIT_00500	COG3708	Transcriptional regulator
RPIT_00545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RPIT_00550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RPIT_00575	COG1215	transferase activity, transferring glycosyl groups
RPIT_00590	COG0673	inositol 2-dehydrogenase activity
RPIT_00600	COG1063	alcohol dehydrogenase
RPIT_00605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RPIT_00615	COG3321	synthase
RPIT_00615	COG0604	alcohol dehydrogenase
RPIT_00615	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_00620	COG0166	Belongs to the GPI family
RPIT_00625	COG2949	membrane
RPIT_00630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RPIT_00635	COG0569	domain protein
RPIT_00640	COG1349	DNA-binding transcription factor activity
RPIT_00650	COG0018	arginyl-trna synthetase
RPIT_00655	COG1940	carbohydrate kinase activity
RPIT_00675	COG0205	6-phosphofructokinase activity
RPIT_00690	COG3291	Pkd domain containing protein
RPIT_00690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
RPIT_00715	COG1464	Belongs to the NlpA lipoprotein family
RPIT_00720	COG2011	ABC-type metal ion transport system permease component
RPIT_00725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RPIT_00740	COG1793	dna ligase
RPIT_00745	COG2095	MarC family integral membrane protein
RPIT_00750	COG1473	amidohydrolase
RPIT_00765	COG0560	Phosphoserine phosphatase
RPIT_00770	COG0659	secondary active sulfate transmembrane transporter activity
RPIT_00780	COG2813	Specifically methylates the guanine in position
RPIT_00795	COG0644	oxidoreductase
RPIT_00800	COG1649	PFAM Uncharacterised BCR, COG1649
RPIT_00815	COG2124	cytochrome p450
RPIT_00845	COG0515	serine threonine protein kinase
RPIT_00850	COG0708	Exodeoxyribonuclease III
RPIT_00860	COG1752	Esterase of the alpha-beta hydrolase superfamily
RPIT_00895	COG1609	Transcriptional regulator
RPIT_00900	COG0673	inositol 2-dehydrogenase activity
RPIT_00910	COG2233	PERMEase
RPIT_00930	COG0737	Belongs to the 5'-nucleotidase family
RPIT_00930	COG1525	nuclease
RPIT_00930	COG4085	toxin activity
RPIT_01000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPIT_01020	COG1802	Transcriptional regulator
RPIT_01035	COG2197	response regulator
RPIT_01040	COG4585	Histidine kinase
RPIT_01065	COG1175	transmembrane transport
RPIT_01070	COG0395	ABC-type sugar transport system, permease component
RPIT_01110	COG0247	lactate metabolic process
RPIT_01115	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
RPIT_01120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RPIT_01205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RPIT_01210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RPIT_01220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIT_01230	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RPIT_01235	COG1131	(ABC) transporter
RPIT_01250	COG0281	malic enzyme
RPIT_01260	COG0673	inositol 2-dehydrogenase activity
RPIT_01265	COG0647	UMP catabolic process
RPIT_01270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RPIT_01285	COG0671	phosphoesterase, PA-phosphatase related
RPIT_01295	COG1879	ABC-type sugar transport system periplasmic component
RPIT_01305	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_01330	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
RPIT_01360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RPIT_01420	COG1111	helicase
RPIT_01420	COG1205	dead DEAH box helicase
RPIT_01440	COG0667	Aldo Keto reductase
RPIT_01450	COG4133	protoheme IX ABC transporter activity
RPIT_01455	COG1754	DNA topoisomerase type I activity
RPIT_01455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RPIT_01465	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RPIT_01475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RPIT_01485	COG1774	PSP1 C-terminal conserved region
RPIT_01500	COG1231	oxidoreductase activity
RPIT_01530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RPIT_01535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RPIT_01540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RPIT_01545	COG2027	D-alanyl-D-alanine carboxypeptidase
RPIT_01555	COG0037	tRNA processing
RPIT_01570	COG0302	gtp cyclohydrolase
RPIT_01575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RPIT_01580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RPIT_01595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RPIT_01605	COG0649	NAD binding
RPIT_01615	COG0542	response to heat
RPIT_01625	COG3842	ATPase activity
RPIT_01635	COG4143	(ABC) transporter
RPIT_01655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RPIT_01685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RPIT_01700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RPIT_01700	COG1648	precorrin-2 dehydrogenase activity
RPIT_01705	COG0406	alpha-ribazole phosphatase activity
RPIT_01710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPIT_01715	COG0785	Cytochrome C biogenesis protein
RPIT_01720	COG1333	cytochrome c biogenesis protein
RPIT_01725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RPIT_01735	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_01750	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_01755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RPIT_01780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RPIT_01785	COG0456	acetyltransferase
RPIT_01790	COG0745	RESPONSE REGULATOR receiver
RPIT_01800	COG1490	D-aminoacyl-tRNA deacylase activity
RPIT_01805	COG3485	protocatechuate 3,4-dioxygenase
RPIT_01815	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RPIT_01820	COG2326	polyphosphate kinase activity
RPIT_01865	COG1461	Dihydroxyacetone kinase
RPIT_01870	COG2376	Dihydroxyacetone kinase
RPIT_01875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RPIT_01890	COG0395	ABC-type sugar transport system, permease component
RPIT_01895	COG1175	transmembrane transport
RPIT_01905	COG0151	Belongs to the GarS family
RPIT_01930	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_01940	COG3012	SEC-C Motif Domain Protein
RPIT_01945	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RPIT_01950	COG0318	PFAM AMP-dependent synthetase and ligase
RPIT_01975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RPIT_01985	COG2094	Belongs to the DNA glycosylase MPG family
RPIT_01990	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RPIT_01995	COG0047	phosphoribosylformylglycinamidine synthase activity
RPIT_02010	COG1404	Belongs to the peptidase S8 family
RPIT_02015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RPIT_02035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIT_02055	COG2070	2-Nitropropane dioxygenase
RPIT_02065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIT_02070	COG0366	Alpha amylase catalytic
RPIT_02090	COG1175	transmembrane transport
RPIT_02095	COG3833	ABC-type maltose transport systems, permease component
RPIT_02100	COG0791	NLP P60 protein
RPIT_02110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RPIT_02115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RPIT_02135	COG1140	nitrate reductase beta subunit
RPIT_02260	COG2801	Transposase and inactivated derivatives
RPIT_02305	COG1131	(ABC) transporter
RPIT_02330	COG2801	Transposase and inactivated derivatives
RPIT_02340	COG0315	cyclic pyranopterin monophosphate synthase activity
RPIT_02345	COG0521	Mo-molybdopterin cofactor biosynthetic process
RPIT_02355	COG0577	efflux transmembrane transporter activity
RPIT_02355	COG1136	(ABC) transporter
RPIT_02385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RPIT_02400	COG1846	Transcriptional regulator
RPIT_02405	COG2814	Major facilitator Superfamily
RPIT_02410	COG2838	Isocitrate dehydrogenase
RPIT_02425	COG3005	denitrification pathway
RPIT_02445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RPIT_02475	COG2056	Na+-H+ antiporter family
RPIT_02485	COG0459	protein refolding
RPIT_02545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RPIT_02550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RPIT_02555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RPIT_02560	COG1461	Dihydroxyacetone kinase
RPIT_02580	COG4948	Mandelate Racemase Muconate Lactonizing
RPIT_02585	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RPIT_02595	COG2226	methyltransferase
RPIT_02610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RPIT_02620	COG1169	isochorismate synthase
RPIT_02625	COG0644	oxidoreductase
RPIT_02635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_02640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_02645	COG0649	NAD binding
RPIT_02655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RPIT_02665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RPIT_02670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_02680	COG0713	ATP synthesis coupled electron transport
RPIT_02695	COG1007	ATP synthesis coupled electron transport
RPIT_02705	COG3590	peptidase
RPIT_02710	COG1295	ribonuclease BN
RPIT_02715	COG1013	pyruvate-flavodoxin oxidoreductase activity
RPIT_02720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RPIT_02720	COG0674	pyruvate-flavodoxin oxidoreductase activity
RPIT_02730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RPIT_02740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_02745	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_02750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_02765	COG2267	carboxylic ester hydrolase activity
RPIT_02770	COG1666	GTP binding
RPIT_02785	COG0813	purine-nucleoside phosphorylase activity
RPIT_02800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RPIT_02805	COG2030	dehydratase
RPIT_02815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RPIT_02825	COG1473	amidohydrolase
RPIT_02835	COG1132	(ABC) transporter
RPIT_02840	COG1132	(ABC) transporter
RPIT_02855	COG0250	Participates in transcription elongation, termination and antitermination
RPIT_02860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RPIT_02865	COG0081	regulation of translation
RPIT_02875	COG1024	Enoyl-CoA hydratase
RPIT_02880	COG0406	alpha-ribazole phosphatase activity
RPIT_02880	COG0328	RNA-DNA hybrid ribonuclease activity
RPIT_02885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RPIT_02890	COG1126	abc transporter atp-binding protein
RPIT_02895	COG0765	amino acid transport
RPIT_02905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RPIT_02910	COG0222	ribosome binding
RPIT_02915	COG0085	RNA polymerase activity
RPIT_02920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RPIT_02925	COG4214	carbohydrate transport
RPIT_02935	COG4213	ABC transporter substrate-binding protein
RPIT_02940	COG1940	carbohydrate kinase activity
RPIT_02940	COG1846	Transcriptional regulator
RPIT_02950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RPIT_02955	COG0049	tRNA binding
RPIT_02960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RPIT_02970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RPIT_02985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RPIT_02990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIT_03000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIT_03005	COG0435	Glutathione S-transferase
RPIT_03035	COG0051	transcription antitermination factor activity, RNA binding
RPIT_03040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RPIT_03045	COG0088	Forms part of the polypeptide exit tunnel
RPIT_03050	COG0089	rRNA binding
RPIT_03055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RPIT_03060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RPIT_03065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RPIT_03070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RPIT_03075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RPIT_03080	COG0255	Belongs to the universal ribosomal protein uL29 family
RPIT_03085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RPIT_03100	COG0730	response to heat
RPIT_03115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RPIT_03120	COG4529	Protein conserved in bacteria
RPIT_03130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPIT_03140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RPIT_03145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RPIT_03150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RPIT_03155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RPIT_03160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RPIT_03165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RPIT_03170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RPIT_03175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RPIT_03180	COG1841	ribosomal large subunit assembly
RPIT_03200	COG0024	Methionine aminopeptidase
RPIT_03225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RPIT_03230	COG3718	enzyme involved in inositol metabolism
RPIT_03235	COG3962	Belongs to the TPP enzyme family
RPIT_03250	COG0395	ABC-type sugar transport system, permease component
RPIT_03255	COG1175	transmembrane transport
RPIT_03270	COG1486	melibiose metabolic process
RPIT_03290	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_03295	COG1129	ABC transporter
RPIT_03305	COG1082	Xylose isomerase domain protein TIM barrel
RPIT_03310	COG0673	inositol 2-dehydrogenase activity
RPIT_03315	COG1082	Xylose isomerase domain protein TIM barrel
RPIT_03320	COG0673	inositol 2-dehydrogenase activity
RPIT_03335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPIT_03340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPIT_03345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RPIT_03350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RPIT_03355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RPIT_03360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RPIT_03370	COG0202	RNA polymerase activity
RPIT_03375	COG0203	ribosomal protein L17
RPIT_03390	COG4120	Belongs to the binding-protein-dependent transport system permease family
RPIT_03395	COG3842	ATPase activity
RPIT_03400	COG0438	transferase activity, transferring glycosyl groups
RPIT_03410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RPIT_03410	COG2755	lipolytic protein G-D-S-L family
RPIT_03420	COG2813	Specifically methylates the guanine in position
RPIT_03425	COG0101	tRNA pseudouridine synthase activity
RPIT_03430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RPIT_03435	COG3304	Inner membrane component domain
RPIT_03445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RPIT_03450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RPIT_03455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RPIT_03465	COG0557	exoribonuclease II activity
RPIT_03485	COG1305	Transglutaminase-like
RPIT_03500	COG0174	glutamine synthetase
RPIT_03510	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RPIT_03515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPIT_03520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIT_03535	COG2409	Drug exporters of the RND superfamily
RPIT_03540	COG0174	glutamine synthetase
RPIT_03545	COG1823	symporter activity
RPIT_03555	COG0488	(ABC) transporter
RPIT_03570	COG0321	lipoyl(octanoyl) transferase activity
RPIT_03580	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIT_03585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPIT_03595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RPIT_03635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RPIT_03640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RPIT_03655	COG1484	DNA-dependent DNA replication
RPIT_03680	COG1668	transmembrane transport
RPIT_03685	COG1215	transferase activity, transferring glycosyl groups
RPIT_03690	COG4152	abc transporter atp-binding protein
RPIT_03705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RPIT_03710	COG0723	plastoquinol--plastocyanin reductase activity
RPIT_03715	COG2010	Cytochrome c
RPIT_03720	COG1845	cytochrome c oxidase, subunit III
RPIT_03735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RPIT_03745	COG3214	Protein conserved in bacteria
RPIT_03750	COG0088	Forms part of the polypeptide exit tunnel
RPIT_03760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RPIT_03795	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RPIT_03810	COG2815	serine threonine protein kinase
RPIT_03810	COG0515	serine threonine protein kinase
RPIT_03815	COG0352	thiamine-phosphate diphosphorylase activity
RPIT_03820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RPIT_03840	COG3973	AAA domain
RPIT_03845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RPIT_03845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RPIT_03870	COG1136	(ABC) transporter
RPIT_03875	COG0577	efflux transmembrane transporter activity
RPIT_03875	COG1136	(ABC) transporter
RPIT_03890	COG3547	Transposase (IS116 IS110 IS902 family)
RPIT_03895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RPIT_03910	COG1132	(ABC) transporter
RPIT_03915	COG0438	transferase activity, transferring glycosyl groups
RPIT_03920	COG0297	glycogen (starch) synthase activity
RPIT_03920	COG0438	transferase activity, transferring glycosyl groups
RPIT_03950	COG0587	DNA-directed DNA polymerase activity
RPIT_03955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RPIT_03980	COG0714	Associated with various cellular activities
RPIT_03985	COG2001	Belongs to the MraZ family
RPIT_03990	COG0275	rRNA processing
RPIT_04010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RPIT_04015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RPIT_04020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RPIT_04025	COG0772	Belongs to the SEDS family
RPIT_04030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RPIT_04035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RPIT_04050	COG1799	cell septum assembly
RPIT_04070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RPIT_04080	COG0469	pyruvate kinase activity
RPIT_04120	COG0539	negative regulation of cytoplasmic translation
RPIT_04125	COG0237	dephospho-CoA kinase activity
RPIT_04130	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPIT_04130	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPIT_04135	COG0509	glycine decarboxylation via glycine cleavage system
RPIT_04140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RPIT_04155	COG0556	nucleotide-excision repair
RPIT_04165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RPIT_04175	COG0322	excinuclease ABC activity
RPIT_04180	COG1268	BioY protein
RPIT_04185	COG1122	ATPase activity
RPIT_04190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RPIT_04195	COG1660	Displays ATPase and GTPase activities
RPIT_04205	COG1481	regulation of sporulation
RPIT_04210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RPIT_04215	COG0126	phosphoglycerate kinase activity
RPIT_04220	COG0149	triose-phosphate isomerase activity
RPIT_04230	COG0765	amino acid transport
RPIT_04235	COG0765	amino acid transport
RPIT_04245	COG1126	abc transporter atp-binding protein
RPIT_04250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RPIT_04260	COG0363	glucosamine-6-phosphate deaminase activity
RPIT_04300	COG0109	protoheme IX farnesyltransferase activity
RPIT_04310	COG2318	DinB family
RPIT_04315	COG0339	signal peptide processing
RPIT_04345	COG0719	Fe-S assembly protein
RPIT_04355	COG0396	ATPase activity
RPIT_04360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RPIT_04365	COG0822	iron-sulfur transferase activity
RPIT_04395	COG0488	(ABC) transporter
RPIT_04410	COG2190	(PTS) system
RPIT_04410	COG2211	Major facilitator Superfamily
RPIT_04415	COG2226	methyltransferase
RPIT_04430	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_04440	COG1119	ATPase activity
RPIT_04465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RPIT_04470	COG0561	phosphatase activity
RPIT_04480	COG0242	peptide deformylase activity
RPIT_04485	COG4974	Belongs to the 'phage' integrase family
RPIT_04490	COG0741	lytic transglycosylase activity
RPIT_04490	COG1196	nuclear chromosome segregation
RPIT_04490	COG0739	heme binding
RPIT_04495	COG0052	Belongs to the universal ribosomal protein uS2 family
RPIT_04500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RPIT_04505	COG0528	UMP kinase activity
RPIT_04510	COG0233	cytoplasmic translational termination
RPIT_04520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RPIT_04525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RPIT_04535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RPIT_04540	COG0750	zinc metalloprotease
RPIT_04545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RPIT_04550	COG0456	acetyltransferase
RPIT_04550	COG0454	-acetyltransferase
RPIT_04555	COG0442	prolyl-tRNA aminoacylation
RPIT_04570	COG0779	Required for maturation of 30S ribosomal subunits
RPIT_04600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RPIT_04605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RPIT_04610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RPIT_04630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RPIT_04635	COG0506	proline dehydrogenase activity
RPIT_04635	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RPIT_04635	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RPIT_04640	COG1185	polyribonucleotide nucleotidyltransferase activity
RPIT_04645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RPIT_04660	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RPIT_04665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RPIT_04670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RPIT_04675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RPIT_04680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RPIT_04690	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RPIT_04695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RPIT_04705	COG0406	alpha-ribazole phosphatase activity
RPIT_04715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RPIT_04720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RPIT_04730	COG0181	hydroxymethylbilane synthase activity
RPIT_04740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RPIT_04745	COG0181	hydroxymethylbilane synthase activity
RPIT_04770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RPIT_04800	COG3773	Cell wall hydrolase
RPIT_04800	COG3409	Peptidoglycan-binding domain 1 protein
RPIT_04825	COG0495	leucyl-tRNA aminoacylation
RPIT_04865	COG0481	GTPase activity
RPIT_04870	COG1643	Atp-dependent helicase
RPIT_04890	COG1725	Transcriptional regulator
RPIT_04895	COG1131	(ABC) transporter
RPIT_04910	COG1725	Transcriptional regulator
RPIT_04955	COG0483	inositol monophosphate 1-phosphatase activity
RPIT_04960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPIT_04965	COG1420	regulation of RNA biosynthetic process
RPIT_04970	COG0484	heat shock protein binding
RPIT_04980	COG0343	queuine tRNA-ribosyltransferase activity
RPIT_05000	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RPIT_05015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RPIT_05030	COG0395	ABC-type sugar transport system, permease component
RPIT_05035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPIT_05050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RPIT_05055	COG1381	Involved in DNA repair and RecF pathway recombination
RPIT_05065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RPIT_05070	COG1121	(ABC) transporter
RPIT_05075	COG0803	Belongs to the bacterial solute-binding protein 9 family
RPIT_05100	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RPIT_05105	COG0358	DNA primase activity
RPIT_05115	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RPIT_05160	COG0714	Associated with various cellular activities
RPIT_05170	COG2304	oxidoreductase activity
RPIT_05175	COG2304	oxidoreductase activity
RPIT_05180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RPIT_05195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RPIT_05200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RPIT_05205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RPIT_05225	COG1115	amino acid carrier protein
RPIT_05235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RPIT_05235	COG1796	DNA polymerase
RPIT_05250	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RPIT_05260	COG0205	6-phosphofructokinase activity
RPIT_05285	COG1610	YqeY-like protein
RPIT_05290	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RPIT_05295	COG2884	Cell division ATP-binding protein ftsE
RPIT_05305	COG0741	lytic transglycosylase activity
RPIT_05305	COG0739	heme binding
RPIT_05305	COG1196	nuclear chromosome segregation
RPIT_05310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RPIT_05325	COG1678	Uncharacterized ACR, COG1678
RPIT_05330	COG0745	RESPONSE REGULATOR receiver
RPIT_05335	COG5000	phosphorelay sensor kinase activity
RPIT_05335	COG5002	protein histidine kinase activity
RPIT_05340	COG5401	PFAM Sporulation and spore germination
RPIT_05345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RPIT_05350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RPIT_05355	COG0653	protein targeting
RPIT_05385	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RPIT_05400	COG0613	PHP domain protein
RPIT_05405	COG0180	Tryptophanyl-tRNA synthetase
RPIT_05425	COG3285	dna ligase
RPIT_05425	COG1793	dna ligase
RPIT_05445	COG1595	DNA-templated transcription, initiation
RPIT_05460	COG0187	DNA topoisomerase II activity
RPIT_05465	COG1556	Lactate utilization protein
RPIT_05470	COG1139	Iron-sulfur cluster binding protein
RPIT_05475	COG0247	lactate metabolic process
RPIT_05480	COG1620	l-lactate permease
RPIT_05485	COG1802	Transcriptional regulator
RPIT_05495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RPIT_05515	COG0438	transferase activity, transferring glycosyl groups
RPIT_05520	COG1435	thymidine kinase activity
RPIT_05550	COG0756	dUTP diphosphatase activity
RPIT_05585	COG2826	transposase and inactivated derivatives, IS30 family
RPIT_05595	COG0569	domain protein
RPIT_05600	COG0531	amino acid
RPIT_05605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RPIT_05610	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RPIT_05620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RPIT_05635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RPIT_05665	COG2860	membrane
RPIT_05675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RPIT_05680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RPIT_05690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RPIT_05700	COG1560	Kdo2-lipid A biosynthetic process
RPIT_05705	COG0438	transferase activity, transferring glycosyl groups
RPIT_05730	COG1716	ATPase activity
RPIT_05750	COG1295	ribonuclease BN
RPIT_05770	COG0656	L-ascorbic acid biosynthetic process
RPIT_05775	COG0009	L-threonylcarbamoyladenylate synthase
RPIT_05795	COG1574	metal-dependent hydrolase with the TIM-barrel fold
RPIT_05820	COG1793	dna ligase
RPIT_05825	COG0395	ABC-type sugar transport system, permease component
RPIT_05875	COG2197	response regulator
RPIT_05880	COG4585	Histidine kinase
RPIT_05895	COG3655	Transcriptional regulator
RPIT_05905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RPIT_05925	COG3654	unkown
RPIT_05935	COG0596	Alpha beta hydrolase
RPIT_05950	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_05960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RPIT_05965	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RPIT_05980	COG3030	protein affecting phage T7 exclusion by the F plasmid
RPIT_05985	COG1216	Glycosyl transferase, family 2
RPIT_05995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RPIT_06000	COG2813	Specifically methylates the guanine in position
RPIT_06000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPIT_06005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPIT_06035	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RPIT_06060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RPIT_06090	COG1160	GTP binding
RPIT_06095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RPIT_06115	COG0546	phosphoglycolate phosphatase activity
RPIT_06120	COG1410	methionine synthase
RPIT_06120	COG0646	methionine synthase
RPIT_06130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RPIT_06140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RPIT_06150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RPIT_06155	COG1758	RNA polymerase activity
RPIT_06160	COG0194	GDP metabolic process
RPIT_06170	COG0284	orotidine-5'-phosphate decarboxylase activity
RPIT_06175	COG0167	dihydroorotate dehydrogenase activity
RPIT_06180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RPIT_06185	COG0505	Belongs to the CarA family
RPIT_06190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RPIT_06195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RPIT_06200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RPIT_06205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RPIT_06210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RPIT_06215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RPIT_06220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RPIT_06230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RPIT_06235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RPIT_06255	COG2814	Major facilitator Superfamily
RPIT_06260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RPIT_06275	COG0124	histidyl-tRNA synthetase
RPIT_06285	COG1196	nuclear chromosome segregation
RPIT_06290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RPIT_06300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RPIT_06305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RPIT_06310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RPIT_06315	COG1862	Preprotein translocase
RPIT_06320	COG2255	four-way junction helicase activity
RPIT_06325	COG0632	four-way junction helicase activity
RPIT_06330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RPIT_06335	COG0217	transcriptional regulatory protein
RPIT_06360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RPIT_06365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RPIT_06370	COG0131	Imidazoleglycerol-phosphate dehydratase
RPIT_06375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RPIT_06380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RPIT_06390	COG0587	DNA-directed DNA polymerase activity
RPIT_06395	COG1840	ABC-type Fe3 transport system, periplasmic component
RPIT_06405	COG3842	ATPase activity
RPIT_06420	COG0070	glutamate synthase
RPIT_06420	COG0069	glutamate synthase activity
RPIT_06420	COG0067	glutamate synthase
RPIT_06430	COG0159	tryptophan synthase activity
RPIT_06435	COG0133	tryptophan synthase activity
RPIT_06440	COG0134	indole-3-glycerol-phosphate synthase activity
RPIT_06455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RPIT_06460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RPIT_06505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RPIT_06510	COG0154	amidase activity
RPIT_06515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RPIT_06530	COG0482	sulfurtransferase activity
RPIT_06535	COG1505	serine-type exopeptidase activity
RPIT_06550	COG0366	Alpha amylase catalytic
RPIT_06560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RPIT_06575	COG0517	IMP dehydrogenase activity
RPIT_06630	COG0596	Alpha beta hydrolase
RPIT_06640	COG2827	Endonuclease containing a URI domain
RPIT_06650	COG2096	Adenosyltransferase
RPIT_06660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RPIT_06665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RPIT_06670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RPIT_06675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RPIT_06680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RPIT_06685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RPIT_06695	COG0356	it plays a direct role in the translocation of protons across the membrane
RPIT_06710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RPIT_06720	COG2890	protein-(glutamine-N5) methyltransferase activity
RPIT_06725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RPIT_06730	COG0254	rRNA binding
RPIT_06740	COG0083	homoserine kinase activity
RPIT_06745	COG0460	homoserine dehydrogenase
RPIT_06750	COG0019	diaminopimelate decarboxylase activity
RPIT_06770	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIT_06770	COG0567	Dehydrogenase, E1 component
RPIT_06775	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RPIT_06800	COG1595	DNA-templated transcription, initiation
RPIT_06805	COG2135	peptidase activity
RPIT_06820	COG1162	GTPase activity
RPIT_06825	COG0483	inositol monophosphate 1-phosphatase activity
RPIT_06830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RPIT_06840	COG0444	Belongs to the ABC transporter superfamily
RPIT_06855	COG0747	negative chemotaxis
RPIT_06860	COG1609	Transcriptional regulator
RPIT_06880	COG0667	Aldo Keto reductase
RPIT_06895	COG1615	UPF0182 protein
RPIT_06925	COG1074	ATP-dependent DNA helicase activity
RPIT_06940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RPIT_06945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RPIT_06945	COG0519	Catalyzes the synthesis of GMP from XMP
RPIT_06955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RPIT_06965	COG1946	Acyl-CoA thioesterase
RPIT_06970	COG1643	Atp-dependent helicase
RPIT_07000	COG0129	dihydroxy-acid dehydratase activity
RPIT_07020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RPIT_07025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RPIT_07035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RPIT_07045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RPIT_07050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RPIT_07055	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RPIT_07070	COG2017	converts alpha-aldose to the beta-anomer
RPIT_07075	COG1418	mRNA catabolic process
RPIT_07080	COG2137	regulation of response to DNA damage stimulus
RPIT_07100	COG1396	sequence-specific DNA binding
RPIT_07105	COG1058	Belongs to the CinA family
RPIT_07105	COG1546	Belongs to the CinA family
RPIT_07115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RPIT_07120	COG1674	ftsk spoiiie
RPIT_07130	COG1181	Belongs to the D-alanine--D-alanine ligase family
RPIT_07150	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RPIT_07160	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_07180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RPIT_07230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RPIT_07265	COG0745	RESPONSE REGULATOR receiver
RPIT_07270	COG2205	protein histidine kinase activity
RPIT_07305	COG2217	Heavy metal translocating P-type atpase
RPIT_07310	COG1937	Protein conserved in bacteria
RPIT_07335	COG3507	Belongs to the glycosyl hydrolase 43 family
RPIT_07340	COG3507	Belongs to the glycosyl hydrolase 43 family
RPIT_07345	COG1609	Transcriptional regulator
RPIT_07440	COG1201	RNA secondary structure unwinding
RPIT_07470	COG0366	Alpha amylase catalytic
RPIT_07515	COG3547	Transposase (IS116 IS110 IS902 family)
RPIT_07595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RPIT_07685	COG1120	ATPase activity
RPIT_07705	COG1309	transcriptional regulator
RPIT_07730	COG3655	Transcriptional regulator
RPIT_07765	COG1506	peptidase
RPIT_07765	COG0823	Involved in the tonB-independent uptake of proteins
RPIT_07795	COG2197	response regulator
RPIT_07840	COG0515	serine threonine protein kinase
RPIT_07870	COG0515	serine threonine protein kinase
RPIT_07885	COG1742	UPF0060 membrane protein
RPIT_07900	COG0066	3-isopropylmalate dehydratase activity
RPIT_07905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RPIT_07910	COG1414	Transcriptional regulator
RPIT_07930	COG1266	CAAX protease self-immunity
RPIT_07935	COG0179	Fumarylacetoacetate (FAA) hydrolase
RPIT_07940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPIT_07945	COG0473	3-isopropylmalate dehydrogenase activity
RPIT_07950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIT_07955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RPIT_07960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RPIT_07965	COG0440	acetolactate synthase activity
RPIT_07985	COG0107	imidazoleglycerol-phosphate synthase activity
RPIT_08005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RPIT_08020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIT_08035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RPIT_08080	COG0504	CTP synthase activity
RPIT_08090	COG0497	DNA recombination
RPIT_08095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RPIT_08150	COG1595	DNA-templated transcription, initiation
RPIT_08185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RPIT_08195	COG0165	Argininosuccinate lyase
RPIT_08210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RPIT_08215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RPIT_08220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RPIT_08240	COG2124	cytochrome p450
RPIT_08255	COG0072	phenylalanine-tRNA ligase activity
RPIT_08255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPIT_08260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RPIT_08265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RPIT_08270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RPIT_08275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RPIT_08280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RPIT_08300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RPIT_08305	COG0140	phosphoribosyl-ATP diphosphatase activity
RPIT_08310	COG0215	cysteine-tRNA ligase activity
RPIT_08330	COG1968	undecaprenyl-diphosphatase activity
RPIT_08335	COG0667	Aldo Keto reductase
RPIT_08420	COG0537	adenosine 5'-monophosphoramidase activity
RPIT_08425	COG2132	Multicopper oxidase
RPIT_08435	COG0745	RESPONSE REGULATOR receiver
RPIT_08440	COG2205	protein histidine kinase activity
RPIT_08445	COG2217	Heavy metal translocating P-type atpase
RPIT_08460	COG1136	(ABC) transporter
RPIT_08460	COG0577	efflux transmembrane transporter activity
RPIT_08490	COG0133	tryptophan synthase activity
RPIT_08495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RPIT_08515	COG3845	ABC transporter
RPIT_08545	COG0792	nuclease activity
RPIT_08555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RPIT_08565	COG0335	large ribosomal subunit rRNA binding
RPIT_08570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RPIT_08575	COG1053	succinate dehydrogenase
RPIT_08585	COG0336	Belongs to the RNA methyltransferase TrmD family
RPIT_08590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RPIT_08595	COG1837	Belongs to the UPF0109 family
RPIT_08600	COG0228	four-way junction DNA binding
RPIT_08640	COG2197	response regulator
RPIT_08660	COG1132	(ABC) transporter
RPIT_08680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RPIT_08685	COG0571	ribonuclease III activity
RPIT_08690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RPIT_08700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RPIT_08705	COG0742	ribosomal rna small subunit methyltransferase
RPIT_08710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RPIT_08725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RPIT_08730	COG1530	ribonuclease E activity
RPIT_08740	COG2807	transmembrane transport
RPIT_08745	COG4868	Belongs to the UPF0371 family
RPIT_08750	COG0596	Alpha beta hydrolase
RPIT_08750	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIT_08755	COG1254	Belongs to the acylphosphatase family
RPIT_08765	COG0105	UTP biosynthetic process
RPIT_08775	COG0285	dihydrofolate synthase activity
RPIT_08785	COG0525	valine-tRNA ligase activity
RPIT_08790	COG4946	Tricorn protease homolog
RPIT_08790	COG0793	Belongs to the peptidase S41A family
RPIT_08800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RPIT_08805	COG0740	serine-type endopeptidase activity
RPIT_08810	COG0740	serine-type endopeptidase activity
RPIT_08815	COG0628	permease
RPIT_08820	COG0544	peptidyl-prolyl cis-trans isomerase activity
RPIT_08860	COG1175	transmembrane transport
RPIT_08875	COG1940	carbohydrate kinase activity
RPIT_08880	COG2066	Belongs to the glutaminase family
RPIT_08900	COG1063	alcohol dehydrogenase
RPIT_08920	COG4552	Acetyltransferase involved in intracellular survival and related
RPIT_08925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RPIT_08940	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RPIT_08945	COG0540	Belongs to the ATCase OTCase family
RPIT_08950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RPIT_08955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RPIT_08960	COG1201	RNA secondary structure unwinding
RPIT_08965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RPIT_08970	COG1609	Transcriptional regulator
RPIT_08975	COG2160	L-arabinose isomerase activity
RPIT_09000	COG0277	FAD linked oxidase domain protein
RPIT_09005	COG1595	DNA-templated transcription, initiation
RPIT_09060	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RPIT_09110	COG1469	GTP cyclohydrolase I activity
RPIT_09190	COG3588	fructose-bisphosphate aldolase
RPIT_09195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIT_09210	COG3118	belongs to the thioredoxin family
RPIT_09215	COG2323	membrane
RPIT_09295	COG1216	Glycosyl transferase, family 2
RPIT_09305	COG0438	transferase activity, transferring glycosyl groups
RPIT_09340	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RPIT_09415	COG1739	Uncharacterized protein family UPF0029
RPIT_09425	COG1595	DNA-templated transcription, initiation
RPIT_09450	COG0537	adenosine 5'-monophosphoramidase activity
RPIT_09475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RPIT_09490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RPIT_09495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RPIT_09500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RPIT_09505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RPIT_09515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RPIT_09545	COG2814	Major facilitator Superfamily
RPIT_09560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RPIT_09570	COG2835	tetraacyldisaccharide 4'-kinase activity
RPIT_09625	COG1316	TRANSCRIPTIONal
RPIT_09630	COG1316	TRANSCRIPTIONal
RPIT_09655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPIT_09665	COG0424	maF-like protein
RPIT_09685	COG4770	biotin carboxylase activity
RPIT_09695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPIT_09710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RPIT_09730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPIT_09740	COG2197	response regulator
RPIT_09755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RPIT_09785	COG1744	ABC transporter substrate-binding protein PnrA-like
RPIT_09800	COG1253	flavin adenine dinucleotide binding
RPIT_09815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RPIT_09820	COG0039	L-malate dehydrogenase activity
RPIT_09840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RPIT_09845	COG0138	bifunctional purine biosynthesis protein purh
RPIT_09870	COG0045	succinate-CoA ligase (ADP-forming) activity
RPIT_09885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RPIT_09900	COG2197	response regulator
RPIT_09925	COG0519	Catalyzes the synthesis of GMP from XMP
RPIT_09925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RPIT_09945	COG1605	Chorismate mutase
RPIT_09945	COG0287	Prephenate dehydrogenase
RPIT_09950	COG0516	GMP reductase activity
RPIT_09965	COG0459	protein refolding
RPIT_09970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RPIT_09975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RPIT_09980	COG0110	maltose O-acetyltransferase activity
RPIT_09990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RPIT_09995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RPIT_10025	COG0601	transmembrane transport
RPIT_10030	COG0747	negative chemotaxis
RPIT_10035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RPIT_10040	COG0456	acetyltransferase
RPIT_10050	COG0802	atpase or kinase
RPIT_10055	COG0513	Belongs to the DEAD box helicase family
RPIT_10065	COG2847	Copper chaperone PCu(A)C
RPIT_10080	COG0736	holo-[acyl-carrier-protein] synthase activity
RPIT_10085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RPIT_10090	COG1072	(Pantothenic acid kinase))
RPIT_10095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIT_10100	COG0006	proline dipeptidase activity
RPIT_10110	COG2264	protein methyltransferase activity
RPIT_10120	COG2239	Acts as a magnesium transporter
RPIT_10140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RPIT_10155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPIT_10165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RPIT_10170	COG0297	glycogen (starch) synthase activity
RPIT_10185	COG1611	Belongs to the LOG family
RPIT_10190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIT_10195	COG1305	Transglutaminase-like
RPIT_10215	COG2171	N-acyltransferase activity
RPIT_10230	COG1132	(ABC) transporter
RPIT_10235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPIT_10245	COG5016	pyruvate
RPIT_10245	COG0511	ligase activity, forming carbon-carbon bonds
RPIT_10270	COG0616	signal peptide processing
RPIT_10315	COG1335	isochorismatase
RPIT_10320	COG3263	regulation of cellular component size
RPIT_10335	COG1045	serine acetyltransferase
RPIT_10345	COG1131	(ABC) transporter
RPIT_10350	COG0842	Transport permease protein
RPIT_10370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RPIT_10385	COG0259	pyridoxamine-phosphate oxidase activity
RPIT_10405	COG1522	sequence-specific DNA binding
RPIT_10410	COG0596	Alpha beta hydrolase
RPIT_10450	COG0745	RESPONSE REGULATOR receiver
RPIT_10465	COG0012	GTP binding
RPIT_10470	COG4607	ABC-type enterochelin transport system periplasmic component
RPIT_10475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RPIT_10480	COG4605	iron ion homeostasis
RPIT_10485	COG4604	ABC transporter, ATP-binding protein
RPIT_10495	COG1362	aminopeptidase activity
RPIT_10500	COG1322	Protein conserved in bacteria
RPIT_10505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RPIT_10510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RPIT_10520	COG1570	exodeoxyribonuclease VII activity
RPIT_10525	COG1722	exodeoxyribonuclease VII activity
RPIT_10535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RPIT_10545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RPIT_10550	COG1331	Highly conserved protein containing a thioredoxin domain
RPIT_10560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RPIT_10570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RPIT_10585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RPIT_10610	COG0667	Aldo Keto reductase
RPIT_10655	COG2268	Band 7 protein
RPIT_10705	COG0148	phosphopyruvate hydratase activity
RPIT_10725	COG0193	aminoacyl-tRNA hydrolase activity
RPIT_10730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RPIT_10740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RPIT_10745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RPIT_10755	COG0745	RESPONSE REGULATOR receiver
RPIT_10780	COG1595	DNA-templated transcription, initiation
RPIT_10830	COG0243	molybdopterin cofactor binding
RPIT_10840	COG3302	dmso reductase anchor subunit
RPIT_10860	COG1715	Restriction endonuclease
RPIT_10865	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
RPIT_10890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RPIT_10895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RPIT_10900	COG0243	molybdopterin cofactor binding
RPIT_10905	COG2223	nitrite transmembrane transporter activity
RPIT_10925	COG2818	Glycosylase
RPIT_10940	COG1846	Transcriptional regulator
RPIT_10945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RPIT_10950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RPIT_10955	COG0084	hydrolase, TatD family'
RPIT_10980	COG1136	(ABC) transporter
RPIT_11000	COG2233	PERMEase
RPIT_11030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RPIT_11045	COG1970	mechanosensitive ion channel activity
RPIT_11090	COG0167	dihydroorotate dehydrogenase activity
RPIT_11095	COG1013	pyruvate-flavodoxin oxidoreductase activity
RPIT_11095	COG0674	pyruvate-flavodoxin oxidoreductase activity
RPIT_11095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RPIT_11095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RPIT_11100	COG0493	'glutamate synthase
RPIT_11105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPIT_11125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RPIT_11140	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RPIT_11150	COG2252	PERMEase
RPIT_11165	COG1278	Cold shock
RPIT_11170	COG0363	glucosamine-6-phosphate deaminase activity
RPIT_11180	COG1051	belongs to the nudix hydrolase family
RPIT_11200	COG0459	protein refolding
RPIT_11240	COG0626	cystathionine gamma-synthase activity
RPIT_11260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RPIT_11265	COG0215	cysteine-tRNA ligase activity
RPIT_11275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RPIT_11290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RPIT_11295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RPIT_11300	COG1329	Transcriptional regulator
RPIT_11315	COG5002	protein histidine kinase activity
RPIT_11320	COG0704	Plays a role in the regulation of phosphate uptake
RPIT_11325	COG0588	phosphoglycerate mutase activity
RPIT_11330	COG0588	phosphoglycerate mutase activity
RPIT_11335	COG0628	permease
RPIT_11350	COG1454	alcohol dehydrogenase
RPIT_11380	COG3458	cephalosporin-C deacetylase activity
RPIT_11395	COG1175	transmembrane transport
RPIT_11400	COG0395	ABC-type sugar transport system, permease component
RPIT_11405	COG1609	Transcriptional regulator
RPIT_11415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RPIT_11430	COG0022	dehydrogenase e1 component
RPIT_11435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPIT_11440	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIT_11445	COG1349	DNA-binding transcription factor activity
RPIT_11455	COG0702	epimerase
RPIT_11465	COG1073	alpha beta
RPIT_11485	COG1070	Carbohydrate kinase
RPIT_11495	COG1609	Transcriptional regulator
RPIT_11500	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_11520	COG1595	DNA-templated transcription, initiation
RPIT_11555	COG0191	fructose-bisphosphate aldolase activity
RPIT_11590	COG1704	LemA family
RPIT_11595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RPIT_11605	COG0728	peptidoglycan biosynthetic process
RPIT_11630	COG1621	beta-fructofuranosidase activity
RPIT_11640	COG0395	ABC-type sugar transport system, permease component
RPIT_11645	COG4209	transmembrane transport
RPIT_11655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIT_11655	COG0723	plastoquinol--plastocyanin reductase activity
RPIT_11660	COG1482	cell wall glycoprotein biosynthetic process
RPIT_11670	COG0395	ABC-type sugar transport system, permease component
RPIT_11690	COG1609	Transcriptional regulator
RPIT_11710	COG0668	transmembrane transport
RPIT_11715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RPIT_11720	COG0517	IMP dehydrogenase activity
RPIT_11720	COG1125	glycine betaine transport
RPIT_11725	COG1174	glycine betaine transport
RPIT_11730	COG1174	glycine betaine transport
RPIT_11740	COG0517	IMP dehydrogenase activity
RPIT_11740	COG4175	Glycine betaine
RPIT_11775	COG0534	Mate efflux family protein
RPIT_11780	COG2133	pyrroloquinoline quinone binding
RPIT_11790	COG0259	pyridoxamine-phosphate oxidase activity
RPIT_11800	COG0542	response to heat
RPIT_11805	COG0366	Alpha amylase catalytic
RPIT_11815	COG4325	translation initiation factor activity
RPIT_11825	COG1472	Belongs to the glycosyl hydrolase 3 family
RPIT_11840	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RPIT_11840	COG0352	thiamine-phosphate diphosphorylase activity
RPIT_11840	COG0351	phosphomethylpyrimidine kinase
RPIT_11845	COG0351	phosphomethylpyrimidine kinase
RPIT_11850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RPIT_11850	COG0352	thiamine-phosphate diphosphorylase activity
RPIT_11850	COG0351	phosphomethylpyrimidine kinase
RPIT_11855	COG0428	transporter
RPIT_11875	COG0058	SHG alpha-glucan phosphorylase activity
RPIT_11890	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RPIT_11895	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RPIT_11915	COG0789	Transcriptional regulator
RPIT_11920	COG0484	heat shock protein binding
RPIT_11925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RPIT_11955	COG1175	transmembrane transport
RPIT_11960	COG0395	ABC-type sugar transport system, permease component
RPIT_11980	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_11990	COG1940	carbohydrate kinase activity
RPIT_11995	COG1129	ABC transporter
RPIT_12000	COG1609	Transcriptional regulator
RPIT_12005	COG1621	beta-fructofuranosidase activity
RPIT_12010	COG1819	glycosyl
RPIT_12030	COG0189	ligase activity
RPIT_12050	COG1100	Small GTP-binding protein
RPIT_12105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RPIT_12130	COG1252	NADH dehydrogenase
RPIT_12135	COG2259	Doxx family
RPIT_12140	COG0745	RESPONSE REGULATOR receiver
RPIT_12145	COG2205	protein histidine kinase activity
RPIT_12160	COG0425	Belongs to the sulfur carrier protein TusA family
RPIT_12165	COG2391	methyltransferase activity
RPIT_12170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RPIT_12175	COG1132	(ABC) transporter
RPIT_12190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RPIT_12195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RPIT_12210	COG3132	Protein of unknown function, DUF480
RPIT_12225	COG0433	COG0433 Predicted ATPase
RPIT_12260	COG0590	tRNA wobble adenosine to inosine editing
RPIT_12270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RPIT_12280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RPIT_12285	COG0584	glycerophosphoryl diester phosphodiesterase
RPIT_12300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RPIT_12310	COG1316	TRANSCRIPTIONal
RPIT_12330	COG0564	pseudouridine synthase activity
RPIT_12360	COG0477	Major facilitator Superfamily
RPIT_12390	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
RPIT_12395	COG1940	carbohydrate kinase activity
RPIT_12400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPIT_12410	COG0444	Belongs to the ABC transporter superfamily
RPIT_12420	COG0747	negative chemotaxis
RPIT_12425	COG2186	Transcriptional regulator
RPIT_12435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RPIT_12440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RPIT_12450	COG2205	protein histidine kinase activity
RPIT_12455	COG0745	RESPONSE REGULATOR receiver
RPIT_12480	COG3402	PFAM membrane-flanked domain
RPIT_12490	COG1131	(ABC) transporter
RPIT_12510	COG3265	gluconokinase activity
RPIT_12515	COG0438	transferase activity, transferring glycosyl groups
RPIT_12525	COG1082	Xylose isomerase domain protein TIM barrel
RPIT_12530	COG1950	PFAM Membrane protein of
RPIT_12570	COG1309	transcriptional regulator
RPIT_12575	COG1131	(ABC) transporter
RPIT_12580	COG3559	Exporter of polyketide antibiotics
RPIT_12610	COG4585	Histidine kinase
RPIT_12615	COG2197	response regulator
RPIT_12625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIT_12635	COG0590	tRNA wobble adenosine to inosine editing
RPIT_12640	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RPIT_12645	COG1088	dTDP-glucose 4,6-dehydratase activity
RPIT_12680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RPIT_12685	COG1716	ATPase activity
RPIT_12705	COG0768	penicillin binding
RPIT_12710	COG0515	serine threonine protein kinase
RPIT_12755	COG2723	6-phospho-beta-galactosidase activity
RPIT_12775	COG1396	sequence-specific DNA binding
RPIT_12785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RPIT_12790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RPIT_12800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RPIT_12810	COG0662	Cupin 2, conserved barrel domain protein
RPIT_12830	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_12835	COG1129	ABC transporter
RPIT_12860	COG0246	Mannitol dehydrogenase
RPIT_12880	COG3012	SEC-C Motif Domain Protein
RPIT_12905	COG2514	catechol 2,3-dioxygenase activity
RPIT_12910	COG2326	polyphosphate kinase activity
RPIT_12920	COG1271	oxidase subunit
RPIT_12925	COG1294	oxidase, subunit
RPIT_12930	COG4988	ABC transporter
RPIT_12945	COG0114	fumarate hydratase activity
RPIT_12960	COG1937	Protein conserved in bacteria
RPIT_12965	COG0305	Participates in initiation and elongation during chromosome replication
RPIT_13020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RPIT_13025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RPIT_13030	COG0686	Belongs to the AlaDH PNT family
RPIT_13050	COG1597	lipid kinase activity
RPIT_13065	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
RPIT_13085	COG2348	transferase activity, transferring amino-acyl groups
RPIT_13100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RPIT_13105	COG0668	transmembrane transport
RPIT_13110	COG0617	tRNA 3'-terminal CCA addition
RPIT_13120	COG2815	serine threonine protein kinase
RPIT_13120	COG0515	serine threonine protein kinase
RPIT_13140	COG1793	dna ligase
RPIT_13145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RPIT_13150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RPIT_13160	COG2409	Drug exporters of the RND superfamily
RPIT_13175	COG3693	PFAM glycoside hydrolase, family 10
RPIT_13200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RPIT_13205	COG0789	Transcriptional regulator
RPIT_13220	COG0861	Integral membrane protein TerC family
RPIT_13230	COG2076	Multidrug Resistance protein
RPIT_13235	COG2076	Multidrug Resistance protein
RPIT_13240	COG2985	domain, Protein
RPIT_13240	COG0569	domain protein
RPIT_13245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIT_13250	COG3655	Transcriptional regulator
RPIT_13260	COG1609	Transcriptional regulator
RPIT_13275	COG1070	Carbohydrate kinase
RPIT_13280	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_13285	COG1129	ABC transporter
RPIT_13295	COG0159	tryptophan synthase activity
RPIT_13325	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RPIT_13330	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RPIT_13345	COG1136	(ABC) transporter
RPIT_13345	COG0577	efflux transmembrane transporter activity
RPIT_13375	COG2354	Protein conserved in bacteria
RPIT_13380	COG0667	Aldo Keto reductase
RPIT_13385	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_13395	COG2409	Drug exporters of the RND superfamily
RPIT_13415	COG1902	pentaerythritol trinitrate reductase activity
RPIT_13470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RPIT_13495	COG2132	Multicopper oxidase
RPIT_13515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RPIT_13520	COG2390	Transcriptional regulator
RPIT_13535	COG3118	belongs to the thioredoxin family
RPIT_13545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIT_13550	COG1181	Belongs to the D-alanine--D-alanine ligase family
RPIT_13570	COG1192	Involved in chromosome partitioning
RPIT_13575	COG0357	Ribosomal RNA small subunit methyltransferase G
RPIT_13585	COG0706	membrane insertase activity
RPIT_13590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RPIT_13600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RPIT_13605	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RPIT_13610	COG1937	Protein conserved in bacteria
RPIT_13620	COG0446	pyridine nucleotide-disulphide oxidoreductase
RPIT_13625	COG1136	(ABC) transporter
RPIT_13635	COG0592	DNA-directed DNA polymerase activity
RPIT_13645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RPIT_13655	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
RPIT_13670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RPIT_13675	COG3266	domain, Protein
RPIT_13685	COG3177	Filamentation induced by cAMP protein fic
RPIT_13700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RPIT_13720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RPIT_13750	COG0457	Tetratricopeptide repeat
RPIT_13750	COG0705	Rhomboid family
RPIT_13760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RPIT_13765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RPIT_13785	COG0489	protein tyrosine kinase activity
RPIT_13795	COG0726	polysaccharide deacetylase
RPIT_13805	COG0438	transferase activity, transferring glycosyl groups
RPIT_13835	COG1216	Glycosyl transferase, family 2
RPIT_13840	COG1215	transferase activity, transferring glycosyl groups
RPIT_13855	COG1215	transferase activity, transferring glycosyl groups
RPIT_13860	COG1216	Glycosyl transferase, family 2
RPIT_13870	COG3958	Transketolase
RPIT_13875	COG3959	Transketolase, thiamine diphosphate binding domain
RPIT_13880	COG0667	Aldo Keto reductase
RPIT_13885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RPIT_13910	COG1569	PIN domain
RPIT_13915	COG1216	Glycosyl transferase, family 2
RPIT_13920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RPIT_14005	COG1215	transferase activity, transferring glycosyl groups
RPIT_14025	COG1132	(ABC) transporter
RPIT_14040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RPIT_14060	COG1215	transferase activity, transferring glycosyl groups
RPIT_14070	COG1086	Polysaccharide biosynthesis protein
RPIT_14085	COG1115	amino acid carrier protein
RPIT_14090	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RPIT_14090	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RPIT_14105	COG0745	RESPONSE REGULATOR receiver
RPIT_14110	COG5002	protein histidine kinase activity
RPIT_14115	COG0439	Biotin carboxylase
RPIT_14135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPIT_14150	COG1132	(ABC) transporter
RPIT_14160	COG2059	Chromate
RPIT_14185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RPIT_14190	COG0431	NADPH-dependent FMN reductase
RPIT_14195	COG1760	l-serine dehydratase
RPIT_14255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RPIT_14280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RPIT_14325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RPIT_14345	COG0574	Belongs to the PEP-utilizing enzyme family
RPIT_14345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIT_14375	COG0733	neurotransmitter:sodium symporter activity
RPIT_14380	COG3022	response to hydroperoxide
RPIT_14405	COG4221	oxidoreductase activity
RPIT_14420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RPIT_14440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIT_14445	COG1320	monovalent cation:proton antiporter activity
RPIT_14455	COG1863	multisubunit Na H antiporter MnhE subunit
RPIT_14470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RPIT_14470	COG2111	Na H antiporter
RPIT_14480	COG1022	Amp-dependent synthetase and ligase
RPIT_14490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RPIT_14500	COG0360	Binds together with S18 to 16S ribosomal RNA
RPIT_14510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RPIT_14515	COG0359	binds to the 23S rRNA
RPIT_14520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RPIT_14540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RPIT_14545	COG3592	Divergent 4Fe-4S mono-cluster
RPIT_14565	COG4651	solute:proton antiporter activity
RPIT_14565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RPIT_14570	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_14580	COG0530	calcium, potassium:sodium antiporter activity
RPIT_14595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RPIT_14630	COG1192	Involved in chromosome partitioning
RPIT_14645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RPIT_14685	COG0823	Involved in the tonB-independent uptake of proteins
RPIT_14685	COG1506	peptidase
RPIT_14715	COG4608	Belongs to the ABC transporter superfamily
RPIT_14720	COG0444	Belongs to the ABC transporter superfamily
RPIT_14725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RPIT_14730	COG0601	transmembrane transport
RPIT_14735	COG4166	transmembrane transport
RPIT_14740	COG1070	Carbohydrate kinase
RPIT_14750	COG0640	Transcriptional regulator
RPIT_14780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RPIT_14805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RPIT_14870	COG2920	part of a sulfur-relay system
RPIT_14875	COG0446	pyridine nucleotide-disulphide oxidoreductase