locus-tag	class	description
RPIT_00020	ENOG410635A	Membrane
RPIT_00030	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
RPIT_00035	ENOG4105DQU	oxidoreductase, subunit beta
RPIT_00045	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
RPIT_00055	ENOG4107QSA	Oxaloacetate decarboxylase
RPIT_00070	ENOG4105CGH	5'-nucleotidase
RPIT_00085	ENOG4108VQR	secreted hydrolase
RPIT_00100	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
RPIT_00105	ENOG4108UVJ	appr-1-p processing domain protein
RPIT_00200	ENOG4107R28	alpha amylase, catalytic region
RPIT_00310	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
RPIT_00340	ENOG4105DBV	ornithine carbamoyltransferase
RPIT_00355	ENOG4105CPP	Dehydrogenase, E1 component
RPIT_00360	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
RPIT_00370	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
RPIT_00380	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
RPIT_00415	ENOG4105CQC	Prephenate dehydratase
RPIT_00420	ENOG4107TE5	Lipid kinase
RPIT_00425	ENOG4107XZQ	multidrug resistance protein
RPIT_00430	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
RPIT_00435	ENOG410667J	hydrolase
RPIT_00440	ENOG4107R7Y	intracellular protease Pfpi family
RPIT_00450	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
RPIT_00465	ENOG4105CDH	Citrulline--aspartate ligase
RPIT_00485	ENOG4105K64	Glycosyl transferase, family 2
RPIT_00495	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
RPIT_00500	ENOG4105UEI	Transcriptional Regulator AraC Family
RPIT_00530	ENOG4105EY8	ABC transporter
RPIT_00590	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
RPIT_00595	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
RPIT_00600	ENOG4105CPQ	Dehydrogenase
RPIT_00620	ENOG4107QP8	phosphohexose isomerase
RPIT_00625	ENOG4108UB4	uncharacterized protein ygjQ
RPIT_00630	ENOG4105CZN	Potassium uptake protein
RPIT_00635	ENOG4107ZYR	domain protein
RPIT_00640	ENOG4105N2W	Transcriptional regulator
RPIT_00650	ENOG4105C75	arginyL-tRNA synthetase
RPIT_00655	ENOG4105DFK	Polyphosphate glucokinase
RPIT_00675	ENOG4105CTQ	phosphohexokinase
RPIT_00690	ENOG4105CPE	K01197 hyaluronoglucosaminidase EC 3.2.1.35
RPIT_00700	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
RPIT_00715	ENOG4105D01	(LipO)protein
RPIT_00720	ENOG4108UMI	ABC transporter, permease
RPIT_00725	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
RPIT_00740	ENOG4108J9Q	DNA ligase
RPIT_00745	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
RPIT_00750	ENOG4105CH2	amidohydrolase
RPIT_00760	ENOG4105CVJ	phosphoglycerate mutase
RPIT_00765	ENOG4105EAC	phosphoserine phosphatase
RPIT_00770	ENOG4105CHH	sulfate transporter
RPIT_00780	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
RPIT_00795	ENOG4108JT6	LycopEne
RPIT_00800	ENOG4105F32	YngK protein
RPIT_00815	ENOG4106A3M	Cytochrome p-450
RPIT_00845	ENOG4107TPY	serine threonine protein kinase
RPIT_00850	ENOG4105CGK	Exodeoxyribonuclease III
RPIT_00860	ENOG4108SKZ	Patatin-like phospholipase
RPIT_00895	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_00910	ENOG4105C2W	permease
RPIT_01020	ENOG4105DRR	Transcriptional regulator, GntR family
RPIT_01035	ENOG4105WH1	Two component transcriptional regulator luxr family
RPIT_01040	ENOG4105BZU	Histidine kinase
RPIT_01050	ENOG4105DA5	(ABC) transporter
RPIT_01070	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
RPIT_01080	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_01110	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
RPIT_01115	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
RPIT_01120	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
RPIT_01205	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
RPIT_01210	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
RPIT_01220	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
RPIT_01230	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
RPIT_01235	ENOG4105CJ1	ABC, transporter
RPIT_01250	ENOG4105C6K	Malic enzyme
RPIT_01260	ENOG4105EE0	oxidoreductase
RPIT_01265	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
RPIT_01270	ENOG4105KRI	phosphocarrier protein (HPr
RPIT_01285	ENOG410841Q	phosphoesterase PA-phosphatase related protein
RPIT_01295	ENOG4107R5U	Periplasmic binding protein LacI transcriptional regulator
RPIT_01300	ENOG4105C2J	ABC transporter
RPIT_01305	ENOG4107R9N	ABC transporter
RPIT_01330	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
RPIT_01360	ENOG4108JQC	penicillin-binding protein 1A
RPIT_01370	ENOG4105P8F	nudix hydrolase
RPIT_01420	ENOG4108I5C	dEAD DEAH box helicase
RPIT_01440	ENOG4105CPC	Aldo Keto reductase
RPIT_01450	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
RPIT_01455	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
RPIT_01465	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
RPIT_01475	ENOG4105C6E	dna polymerase iii
RPIT_01485	ENOG4105MA4	psp1 domain protein
RPIT_01535	ENOG4108680	CrcB-like protein
RPIT_01540	ENOG4105F0N	pyrophosphate phospho-hydrolase
RPIT_01545	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
RPIT_01555	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
RPIT_01570	ENOG4105EUJ	GTP cyclohydrolase i
RPIT_01575	ENOG4105EEI	dihydropteroate synthase
RPIT_01595	ENOG4105EEI	dihydropteroate synthase
RPIT_01605	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
RPIT_01615	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
RPIT_01625	ENOG4108UCS	ABC, transporter
RPIT_01635	ENOG4105DP9	ABC transporter
RPIT_01655	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
RPIT_01685	ENOG4105II7	pyrroline-5-carboxylate reductase
RPIT_01700	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
RPIT_01705	ENOG4108RH7	phosphoglycerate mutase
RPIT_01710	ENOG4107ZT5	Thiol disulfide interchange protein
RPIT_01715	ENOG4107QIV	Cytochrome c biogenesis protein
RPIT_01720	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
RPIT_01725	ENOG4105CRE	cytochrome C
RPIT_01745	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
RPIT_01750	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
RPIT_01755	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
RPIT_01770	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
RPIT_01780	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
RPIT_01785	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
RPIT_01790	ENOG4107NHD	transcriptional regulator
RPIT_01800	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
RPIT_01805	ENOG4108SVG	May play a role in the intracellular transport of hydrophobic ligands
RPIT_01815	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
RPIT_01820	ENOG4105CSR	polyphosphate kinase 2
RPIT_01845	ENOG4105CI3	gtp-binding protein typa
RPIT_01865	ENOG4108UTZ	Dihydroxyacetone kinase
RPIT_01870	ENOG4105CMT	Dihydroxyacetone kinase
RPIT_01875	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
RPIT_01890	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
RPIT_01895	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
RPIT_01905	ENOG4105C12	Phosphoribosylglycinamide synthetase
RPIT_01910	ENOG4107SVN	transposase
RPIT_01925	ENOG4105CHU	acetyl-coa acetyltransferase
RPIT_01930	ENOG4105CHR	reductase
RPIT_01940	ENOG4105K5B	UPF0225 protein
RPIT_01945	ENOG4105C83	adenylosuccinate lyase
RPIT_01950	ENOG4105CEY	Amp-dependent synthetase and ligase
RPIT_01975	ENOG4105C8V	SAICAR synthetase
RPIT_01985	ENOG4108VX5	3-methyladenine DNA glycosylase
RPIT_01990	ENOG410839H	phosphoribosylformylglycinamidine synthase
RPIT_01995	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
RPIT_02010	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
RPIT_02015	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
RPIT_02020	ENOG4107SVN	transposase
RPIT_02035	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
RPIT_02050	ENOG4108IJ0	Aspartate ammonia-lyase
RPIT_02055	ENOG4105EA8	2-Nitropropane dioxygenase
RPIT_02065	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
RPIT_02070	ENOG4105CG3	alpha amylase, catalytic region
RPIT_02090	ENOG4105D56	permease protein
RPIT_02095	ENOG4105EG2	ABC transporter, permease
RPIT_02100	ENOG4105K4H	Nlp p60 protein
RPIT_02115	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
RPIT_02135	ENOG4108IUE	nitrate reductase beta subunit
RPIT_02305	ENOG4105DA5	(ABC) transporter
RPIT_02340	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
RPIT_02345	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
RPIT_02350	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
RPIT_02355	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
RPIT_02385	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
RPIT_02400	ENOG4105XMC	MarR family Transcriptional regulator
RPIT_02405	ENOG4107SFI	Major Facilitator superfamily
RPIT_02410	ENOG4105E9K	Isocitrate dehydrogenase
RPIT_02425	ENOG4108W6G	cytochrome C
RPIT_02440	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
RPIT_02445	ENOG4105CRE	cytochrome C
RPIT_02475	ENOG4105D3Y	Na H antiporter
RPIT_02485	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
RPIT_02515	ENOG4105CG3	alpha amylase, catalytic region
RPIT_02520	ENOG4105CG3	alpha amylase, catalytic region
RPIT_02530	ENOG4107QW3	Sucrose phosphorylase
RPIT_02550	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
RPIT_02555	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
RPIT_02560	ENOG4108UTZ	Dihydroxyacetone kinase
RPIT_02580	ENOG4107TCW	O-succinylbenzoate synthase
RPIT_02585	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
RPIT_02595	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
RPIT_02610	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
RPIT_02620	ENOG4105E4F	Isochorismate synthase
RPIT_02625	ENOG4105P52	geranylgeranyl reductase
RPIT_02635	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
RPIT_02640	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RPIT_02645	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
RPIT_02655	ENOG4107QIZ	NADH dehydrogenase
RPIT_02665	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
RPIT_02670	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
RPIT_02675	ENOG4105DF2	NADH dehydrogenase subunit j
RPIT_02680	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
RPIT_02695	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
RPIT_02705	ENOG4105C9K	Endothelin-converting enzyme 1
RPIT_02710	ENOG4107S2Z	UPF0761 membrane protein
RPIT_02715	ENOG4105DQU	oxidoreductase, subunit beta
RPIT_02720	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
RPIT_02730	ENOG4105C0D	helicase
RPIT_02740	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
RPIT_02745	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RPIT_02750	ENOG4108M11	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
RPIT_02755	ENOG4107JC6	Membrane
RPIT_02765	ENOG4106HB6	Alpha beta hydrolase
RPIT_02770	ENOG4108VPT	UPF0234 protein
RPIT_02785	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
RPIT_02800	ENOG4105WDJ	50S ribosomal protein L33
RPIT_02805	ENOG410900P	UPF0336 protein
RPIT_02815	ENOG4107R4N	Cell wall formation (By similarity)
RPIT_02835	ENOG4105BZ1	(ABC) transporter
RPIT_02840	ENOG4105BZ1	(ABC) transporter
RPIT_02855	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
RPIT_02860	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
RPIT_02865	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
RPIT_02875	ENOG4105E39	Enoyl-CoA hydratase
RPIT_02880	ENOG4105CVJ	phosphoglycerate mutase
RPIT_02885	ENOG4107Z4K	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
RPIT_02890	ENOG4105CDA	abc transporter atp-binding protein
RPIT_02895	ENOG4105DRP	amino acid AbC transporter
RPIT_02905	ENOG4108VZM	50s ribosomal protein L10
RPIT_02910	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
RPIT_02915	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
RPIT_02920	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
RPIT_02925	ENOG4108HWW	ABC transporter
RPIT_02935	ENOG4105DFW	ABC transporter
RPIT_02940	ENOG4105E2R	ROK family
RPIT_02950	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
RPIT_02955	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
RPIT_02960	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
RPIT_02970	ENOG4105F1A	Pyruvate formate-lyase
RPIT_02985	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
RPIT_02990	ENOG4105CX6	glutaminyL-tRNA synthetase
RPIT_03000	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
RPIT_03005	ENOG4105CHF	Glutathione S-transferase
RPIT_03035	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
RPIT_03040	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
RPIT_03045	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
RPIT_03050	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
RPIT_03055	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RPIT_03060	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
RPIT_03065	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
RPIT_03070	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
RPIT_03075	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
RPIT_03080	ENOG41082SA	50s ribosomal protein l29
RPIT_03085	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
RPIT_03100	ENOG4108VCT	Sulfite exporter TauE/SafE
RPIT_03120	ENOG4108KTU	conserved protein with FAD NAD(P)-binding domain
RPIT_03130	ENOG4105E9Z	Nad-dependent epimerase dehydratase
RPIT_03140	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
RPIT_03145	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
RPIT_03150	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RPIT_03155	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
RPIT_03160	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
RPIT_03165	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
RPIT_03170	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
RPIT_03175	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
RPIT_03180	ENOG410849U	50S ribosomal protein L30
RPIT_03185	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
RPIT_03190	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
RPIT_03200	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
RPIT_03225	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
RPIT_03230	ENOG4105DH8	myo-inositol catabolism
RPIT_03235	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
RPIT_03250	ENOG4105DRS	transport system, permease
RPIT_03255	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
RPIT_03270	ENOG4105F8D	glycoside hydrolase family 4
RPIT_03285	ENOG4105C26	Dehydrogenase
RPIT_03290	ENOG4105CNN	ABC, transporter
RPIT_03295	ENOG4105C2J	ABC transporter
RPIT_03305	ENOG4105F0H	myo-inositol catabolism protein
RPIT_03310	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
RPIT_03345	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
RPIT_03350	ENOG41067V7	50S ribosomal protein L36
RPIT_03355	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RPIT_03360	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
RPIT_03370	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
RPIT_03375	ENOG4108ZT0	50S ribosomal protein l17
RPIT_03390	ENOG4105C7J	ABC transporter, permease
RPIT_03395	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
RPIT_03400	ENOG4108MJN	Glycosyl Transferase
RPIT_03410	ENOG4105EXC	Acyl-transferase
RPIT_03415	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
RPIT_03420	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
RPIT_03425	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
RPIT_03430	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
RPIT_03435	ENOG410901E	Membrane
RPIT_03445	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
RPIT_03450	ENOG4108UJD	30S ribosomal protein S9
RPIT_03455	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
RPIT_03465	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
RPIT_03500	ENOG4105C5F	glutamine synthetase
RPIT_03510	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
RPIT_03515	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
RPIT_03520	ENOG4107XKF	NMT1 THI5 Like Domain Protein
RPIT_03540	ENOG4105C5F	glutamine synthetase
RPIT_03545	ENOG4107R6U	sodium dicarboxylate symporter
RPIT_03555	ENOG4105C5H	ABC transporter
RPIT_03570	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
RPIT_03595	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
RPIT_03635	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
RPIT_03640	ENOG4105BZ9	Cytochrome C oxidase, subunit I
RPIT_03655	ENOG4105F5W	AtP-binding protein
RPIT_03680	ENOG4105RHA	ABC transporter, permease
RPIT_03685	ENOG4107QZ7	Cellulose synthase catalytic subunit
RPIT_03690	ENOG4108IUX	(ABC) transporter
RPIT_03695	ENOG4105EUB	pirin domain protein
RPIT_03705	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
RPIT_03710	ENOG4107EUI	c reductase, iron-sulfur
RPIT_03715	ENOG4107UDY	cytochrome C
RPIT_03720	ENOG4105CCU	oxidase (Subunit III)
RPIT_03735	ENOG4108I0Q	anthranilate phosphoribosyltransferase
RPIT_03745	ENOG4105T0Z	Conserved Protein
RPIT_03750	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
RPIT_03760	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
RPIT_03795	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
RPIT_03815	ENOG4107Y5I	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
RPIT_03820	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
RPIT_03840	ENOG4105EEM	helicase
RPIT_03845	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
RPIT_03870	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
RPIT_03875	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
RPIT_03890	ENOG41085W3	Transposase
RPIT_03895	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
RPIT_03910	ENOG4105BZ1	(ABC) transporter
RPIT_03915	ENOG4107EF8	Glycosyl transferase (Group 1
RPIT_03920	ENOG4107RA4	Glycosyl transferase (Group 1
RPIT_03950	ENOG4105C0B	DNA polymerase III (alpha subunit)
RPIT_03955	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
RPIT_03980	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
RPIT_03985	ENOG4108V6E	Cell division protein mraZ
RPIT_03990	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
RPIT_04000	ENOG4105CJN	penicillin-binding protein
RPIT_04015	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
RPIT_04020	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
RPIT_04025	ENOG4105CNI	cell division protein FtsW
RPIT_04030	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
RPIT_04035	ENOG4105DFU	Cell wall formation (By similarity)
RPIT_04040	ENOG4105ME9	cell division protein FtsQ
RPIT_04045	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
RPIT_04050	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
RPIT_04080	ENOG4105CA9	Pyruvate kinase
RPIT_04095	ENOG4105KA0	thioesterase Superfamily protein
RPIT_04120	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
RPIT_04125	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
RPIT_04130	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPIT_04135	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
RPIT_04140	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
RPIT_04155	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
RPIT_04165	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
RPIT_04175	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
RPIT_04180	ENOG4107ZYJ	bioY protein
RPIT_04185	ENOG4108JJB	ABC transporter
RPIT_04190	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
RPIT_04195	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
RPIT_04205	ENOG4105CIE	May be required for sporulation (By similarity)
RPIT_04210	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
RPIT_04215	ENOG4105BZA	Phosphoglycerate kinase
RPIT_04220	ENOG4105CP7	Triose-phosphate isomerase
RPIT_04230	ENOG4105DRP	amino acid AbC transporter
RPIT_04235	ENOG4108Q1T	ABC transporter
RPIT_04245	ENOG4105CDA	abc transporter atp-binding protein
RPIT_04260	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
RPIT_04300	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
RPIT_04315	ENOG4105DGW	oligopeptidase A
RPIT_04320	ENOG4107SGF	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
RPIT_04345	ENOG4105JRK	feS assembly protein SufD
RPIT_04355	ENOG4105C3K	feS assembly ATPase SufC
RPIT_04360	ENOG4105C9B	Cysteine desulfurase
RPIT_04365	ENOG4108UNV	SUF system FeS assembly protein, NifU family
RPIT_04395	ENOG4105C5H	ABC transporter
RPIT_04400	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
RPIT_04405	ENOG4105CG3	alpha amylase, catalytic region
RPIT_04410	ENOG4107RBJ	symporter
RPIT_04430	ENOG4105CHR	reductase
RPIT_04440	ENOG4105DKW	ABC transporter
RPIT_04455	ENOG4105DHU	Bile acid
RPIT_04465	ENOG4105FCS	tRNA rRNA methyltransferase
RPIT_04470	ENOG4108HCJ	Hydrolase
RPIT_04480	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
RPIT_04485	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
RPIT_04490	ENOG4105E4C	Lytic transglycosylase catalytic
RPIT_04495	ENOG4105CE9	30S ribosomal protein S2
RPIT_04500	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
RPIT_04505	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
RPIT_04510	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
RPIT_04520	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
RPIT_04525	ENOG4105D82	Glutamate dehydrogenase
RPIT_04535	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
RPIT_04540	ENOG4105DZP	Membrane-associated zinc metalloprotease
RPIT_04545	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
RPIT_04550	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
RPIT_04555	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
RPIT_04570	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
RPIT_04600	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
RPIT_04605	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
RPIT_04610	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
RPIT_04630	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
RPIT_04635	ENOG4105C26	Dehydrogenase
RPIT_04640	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
RPIT_04645	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
RPIT_04660	ENOG4105CN5	Metallo-Beta-Lactamase
RPIT_04665	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
RPIT_04670	ENOG4105K46	50S ribosomal protein l27
RPIT_04675	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RPIT_04680	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
RPIT_04690	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
RPIT_04695	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
RPIT_04705	ENOG4105CVJ	phosphoglycerate mutase
RPIT_04715	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
RPIT_04720	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
RPIT_04725	ENOG4105C1Q	protoporphyrinogen oxidase
RPIT_04730	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
RPIT_04740	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
RPIT_04745	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
RPIT_04755	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
RPIT_04770	ENOG4108S0S	Nucleotidyl transferase
RPIT_04825	ENOG4105C8T	Leucyl-tRNA synthetase
RPIT_04865	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
RPIT_04870	ENOG4105CQ7	ATP-dependent helicase
RPIT_04890	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
RPIT_04895	ENOG4105CZV	ABC transporter
RPIT_04910	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
RPIT_04955	ENOG4108MWI	inositol mono-phosphatase
RPIT_04960	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
RPIT_04965	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
RPIT_04970	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
RPIT_04980	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
RPIT_05000	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
RPIT_05015	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
RPIT_05030	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
RPIT_05035	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
RPIT_05050	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
RPIT_05055	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
RPIT_05070	ENOG4105FDK	ABC transporter
RPIT_05075	ENOG4105DSE	periplasmic solute binding protein
RPIT_05100	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
RPIT_05105	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
RPIT_05115	ENOG4107QN1	sodium solute
RPIT_05160	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
RPIT_05170	ENOG4107QVM	von Willebrand factor, type A
RPIT_05175	ENOG4107QVM	von Willebrand factor, type A
RPIT_05180	ENOG4105DFA	alanine racemase domain protein
RPIT_05200	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
RPIT_05225	ENOG4105BZG	amino acid carrier protein
RPIT_05235	ENOG4105DCG	PHP domain protein
RPIT_05250	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
RPIT_05260	ENOG4105CTQ	phosphohexokinase
RPIT_05265	ENOG4107SVN	transposase
RPIT_05285	ENOG4105KTH	gatB Yqey
RPIT_05290	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
RPIT_05295	ENOG4105CAK	Cell division ATP-binding protein ftsE
RPIT_05305	ENOG4105E4C	Lytic transglycosylase catalytic
RPIT_05310	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
RPIT_05325	ENOG4108UJU	UPF0301 protein
RPIT_05330	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
RPIT_05335	ENOG4105BZU	Histidine kinase
RPIT_05340	ENOG4105G3P	Lipoprotein lpqB
RPIT_05345	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
RPIT_05350	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
RPIT_05355	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
RPIT_05385	ENOG4105FDF	Could be involved in DNA repair (By similarity)
RPIT_05400	ENOG4105DB7	PHP domain protein
RPIT_05405	ENOG4105C31	Tryptophanyl-tRNA synthetase
RPIT_05425	ENOG4105DQE	DNA ligase
RPIT_05445	ENOG4105NAF	rna polymerase sigma factor
RPIT_05460	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
RPIT_05465	ENOG41080R8	Conserved Protein
RPIT_05470	ENOG4107QR9	Iron-sulfur cluster binding protein
RPIT_05475	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
RPIT_05480	ENOG4105DAA	L-lactate
RPIT_05485	ENOG4105DRR	Transcriptional regulator, GntR family
RPIT_05495	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
RPIT_05520	ENOG4107W53	thymidine kinase
RPIT_05550	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
RPIT_05575	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
RPIT_05585	ENOG4105F9F	transposase
RPIT_05595	ENOG4107VEG	TrkA-N domain protein
RPIT_05600	ENOG4105C0X	amino acid
RPIT_05605	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
RPIT_05610	ENOG4107QM5	aconitate hydratase
RPIT_05620	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
RPIT_05635	ENOG4105E0X	reductase
RPIT_05665	ENOG4105EN6	Membrane
RPIT_05675	ENOG4105CM2	brancheD-chain amino acid aminotransferase
RPIT_05680	ENOG4108Z66	YbaK ebsC protein
RPIT_05690	ENOG4105C22	threonyL-tRNA synthetase
RPIT_05700	ENOG4107YQ3	lipid a biosynthesis lauroyl acyltransferase
RPIT_05705	ENOG4105E2K	Glycosyl transferase (Group 1
RPIT_05730	ENOG4108UW8	fha domain-containing protein
RPIT_05750	ENOG4107H3J	ribonuclease
RPIT_05770	ENOG4105CV8	reductase
RPIT_05775	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
RPIT_05795	ENOG4105EFZ	amidohydrolase
RPIT_05820	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
RPIT_05825	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
RPIT_05875	ENOG4105WH1	Two component transcriptional regulator luxr family
RPIT_05880	ENOG4105ENE	Histidine kinase
RPIT_05895	ENOG4105VMP	Transcriptional regulator
RPIT_05905	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
RPIT_05925	ENOG41086VY	Fic/DOC family
RPIT_05935	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
RPIT_05950	ENOG4105CHR	reductase
RPIT_05960	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
RPIT_05965	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
RPIT_05975	ENOG4105Q70	
RPIT_05980	ENOG4105FS0	cytoplasmic membrane protein
RPIT_05985	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
RPIT_05995	ENOG4105HFS	5'-3' exonuclease
RPIT_06000	ENOG4105DWV	Homoserine O-trans-acetylase
RPIT_06005	ENOG4105DWV	Homoserine O-trans-acetylase
RPIT_06035	ENOG4105CKU	formyltetrahydrofolate synthetase
RPIT_06060	ENOG4105CNG	UPF0061 protein
RPIT_06090	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
RPIT_06095	ENOG4105CAT	Cytidine monophosphate kinase
RPIT_06115	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
RPIT_06120	ENOG4105C3R	Methionine synthase
RPIT_06130	ENOG4105DJV	ribulose-phosphate 3-epimerase
RPIT_06140	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
RPIT_06150	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
RPIT_06155	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
RPIT_06160	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
RPIT_06170	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
RPIT_06175	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
RPIT_06180	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
RPIT_06185	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
RPIT_06190	ENOG410803B	Involved in the transcription termination process (By similarity)
RPIT_06195	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
RPIT_06200	ENOG4105C94	Transporter
RPIT_06205	ENOG4105D49	3-dehydroquinate synthase
RPIT_06210	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
RPIT_06215	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
RPIT_06220	ENOG4105E2X	shikimate dehydrogenase
RPIT_06230	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
RPIT_06235	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
RPIT_06255	ENOG4105C2C	drug resistance transporter, Bcr CflA
RPIT_06260	ENOG4105C9M	aspartyl-trna synthetase
RPIT_06275	ENOG4105CUT	histidyl-tRNA synthetase
RPIT_06285	ENOG4105C99	atpase involved in dna repair
RPIT_06290	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
RPIT_06300	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
RPIT_06305	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
RPIT_06310	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
RPIT_06315	ENOG4105VIE	preprotein translocase, subunit YajC
RPIT_06320	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
RPIT_06325	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
RPIT_06330	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
RPIT_06335	ENOG4105CDY	transcriptional regulatory protein
RPIT_06360	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
RPIT_06365	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
RPIT_06370	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
RPIT_06375	ENOG4105CIH	Imidazole acetol-phosphate transaminase
RPIT_06380	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
RPIT_06390	ENOG4105C0B	DNA polymerase III (alpha subunit)
RPIT_06395	ENOG4105C4Y	ABC transporter
RPIT_06400	ENOG4107RCV	ABC transporter, permease
RPIT_06405	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
RPIT_06420	ENOG4105CBC	glutamate synthase
RPIT_06435	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
RPIT_06440	ENOG4105DK0	Indole-3-glycerol phosphate synthase
RPIT_06455	ENOG4105CRQ	synthase (Component I)
RPIT_06460	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
RPIT_06505	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
RPIT_06510	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
RPIT_06515	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
RPIT_06530	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
RPIT_06550	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
RPIT_06560	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
RPIT_06575	ENOG41080XP	Cbs domain
RPIT_06620	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
RPIT_06630	ENOG4105EV9	Alpha Beta Hydrolase
RPIT_06635	ENOG4107SVN	transposase
RPIT_06640	ENOG4105VC4	domain protein
RPIT_06650	ENOG4108WBT	adenosyltransferase
RPIT_06660	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
RPIT_06665	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
RPIT_06670	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
RPIT_06675	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
RPIT_06680	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
RPIT_06685	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
RPIT_06690	ENOG4105ZA1	atp synthase
RPIT_06695	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
RPIT_06710	ENOG4105ESV	Glycosyl transferase, family 4
RPIT_06720	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
RPIT_06725	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
RPIT_06730	ENOG4105VFB	Binds the 23S rRNA (By similarity)
RPIT_06740	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
RPIT_06745	ENOG4105D6E	homoserine dehydrogenase
RPIT_06750	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
RPIT_06770	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
RPIT_06775	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
RPIT_06800	ENOG4105EMN	RNA polymerase sigma factor
RPIT_06805	ENOG4108RAV	Conserved protein
RPIT_06815	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
RPIT_06820	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
RPIT_06825	ENOG4107TK4	histidinol-phosphate phosphatase
RPIT_06830	ENOG4108JQ1	Dehydrogenase
RPIT_06835	ENOG4108JQ7	(ABC) transporter
RPIT_06845	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
RPIT_06855	ENOG4105DEF	Extracellular solute-binding protein, family 5
RPIT_06860	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_06880	ENOG4105CPC	Aldo Keto reductase
RPIT_06895	ENOG4105DJZ	UPF0182 protein
RPIT_06925	ENOG4107QKA	exodeoxyribonuclease V beta
RPIT_06935	ENOG4105CGF	Aromatic amino acid aminotransferase
RPIT_06940	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
RPIT_06945	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
RPIT_06955	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
RPIT_06965	ENOG4105C29	acyl-CoA thioesterase
RPIT_06970	ENOG4105CQ7	ATP-dependent helicase
RPIT_07000	ENOG4105C01	Dihydroxy-acid dehydratase
RPIT_07010	ENOG4105KHC	sulfurtransferase
RPIT_07020	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
RPIT_07025	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
RPIT_07035	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
RPIT_07045	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
RPIT_07050	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
RPIT_07055	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
RPIT_07070	ENOG4107WI4	Aldose-1-epimerase
RPIT_07075	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
RPIT_07080	ENOG4105KC9	Modulates RecA activity (By similarity)
RPIT_07085	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
RPIT_07100	ENOG4105WBV	Transcriptional regulator
RPIT_07105	ENOG4105CEV	competence damage-inducible protein
RPIT_07115	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
RPIT_07120	ENOG4107QZI	cell division protein FtsK
RPIT_07130	ENOG4105CPF	Cell wall formation (By similarity)
RPIT_07150	ENOG4105NAE	bifunctional deaminase-reductase domain protein
RPIT_07160	ENOG4108PSK	reductase
RPIT_07180	ENOG4105C8Y	Acetylornithine aminotransferase
RPIT_07220	ENOG4107SVN	transposase
RPIT_07230	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
RPIT_07265	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
RPIT_07270	ENOG4105EB3	Histidine kinase
RPIT_07305	ENOG4105C59	p-type ATPase
RPIT_07310	ENOG4105VPX	protein, conserved in bacteria
RPIT_07340	ENOG4105DSG	hydrolase family 43
RPIT_07345	ENOG4105DDV	Transcriptional regulator (LacI family
RPIT_07440	ENOG4107QRT	dEAD DEAH box helicase
RPIT_07470	ENOG4105CG3	alpha amylase, catalytic region
RPIT_07515	ENOG410836F	Transposase
RPIT_07595	ENOG4105C0D	helicase
RPIT_07685	ENOG4105E0A	ABC, transporter
RPIT_07705	ENOG4108JGH	Tetr family transcriptional regulator
RPIT_07730	ENOG4105VMP	Transcriptional regulator
RPIT_07765	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
RPIT_07795	ENOG4105WH1	Two component transcriptional regulator luxr family
RPIT_07825	ENOG4108W9Q	Endoglucanase (EC 3.2.1.4)
RPIT_07840	ENOG4108UGD	Serine Threonine protein kinase
RPIT_07870	ENOG4108UGD	Serine Threonine protein kinase
RPIT_07885	ENOG4105KK4	UPF0060 membrane protein
RPIT_07900	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
RPIT_07905	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
RPIT_07910	ENOG41069M3	Transcriptional regulator
RPIT_07930	ENOG4107FCW	Abortive infection protein
RPIT_07935	ENOG4105ERH	Fumarylacetoacetate hydrolase
RPIT_07940	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
RPIT_07945	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
RPIT_07950	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
RPIT_07955	ENOG41068WN	
RPIT_07960	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
RPIT_07965	ENOG4108ZP8	Acetolactate synthase small subunit
RPIT_07980	ENOG4105K59	histidine triad (HIT) protein
RPIT_07985	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
RPIT_08005	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
RPIT_08020	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
RPIT_08035	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
RPIT_08080	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
RPIT_08090	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
RPIT_08095	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
RPIT_08150	ENOG4105NAF	rna polymerase sigma factor
RPIT_08185	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
RPIT_08195	ENOG4105CH7	arginosuccinase
RPIT_08210	ENOG4105CAS	nag kinase
RPIT_08215	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
RPIT_08220	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
RPIT_08255	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
RPIT_08260	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
RPIT_08265	ENOG4108RWN	rrna methyltransferase
RPIT_08270	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
RPIT_08275	ENOG41084BS	50S ribosomal protein L35
RPIT_08280	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
RPIT_08300	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
RPIT_08305	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
RPIT_08310	ENOG4105C8N	cysteinyl-tRNA synthetase
RPIT_08330	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
RPIT_08335	ENOG4108FN7	Aldo keto reductase
RPIT_08390	ENOG4105CB5	ATP-dependent DNA helicase recG
RPIT_08405	ENOG4105D5G	Transposase
RPIT_08420	ENOG4107Z60	histidine triad (HIT) protein
RPIT_08425	ENOG4107R16	Multicopper oxidase
RPIT_08435	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
RPIT_08440	ENOG4105EB3	Histidine kinase
RPIT_08460	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
RPIT_08490	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
RPIT_08495	ENOG4107VXZ	Hydrolase
RPIT_08515	ENOG4108JJB	ABC transporter
RPIT_08545	ENOG41080R2	UPF0102 protein
RPIT_08555	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
RPIT_08565	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
RPIT_08570	ENOG4105E33	succinate dehydrogenase
RPIT_08585	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
RPIT_08590	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
RPIT_08595	ENOG41082KU	UPF0109 protein
RPIT_08600	ENOG4105K5M	30s ribosomal protein S16
RPIT_08640	ENOG4105WH1	Two component transcriptional regulator luxr family
RPIT_08660	ENOG4105BZ1	(ABC) transporter
RPIT_08680	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
RPIT_08685	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
RPIT_08690	ENOG41084BZ	50S ribosomal protein L32
RPIT_08700	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
RPIT_08705	ENOG4106H78	methyltransferase
RPIT_08710	ENOG4105CB5	ATP-dependent DNA helicase recG
RPIT_08725	ENOG4105VB9	50S ribosomal protein l28
RPIT_08730	ENOG4105C03	ribonuclease
RPIT_08740	ENOG4105DJ2	Major Facilitator Superfamily
RPIT_08745	ENOG4105DPH	UPF0371 protein
RPIT_08750	ENOG4107TTQ	Alpha beta hydrolase fold
RPIT_08755	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
RPIT_08765	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
RPIT_08775	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
RPIT_08785	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
RPIT_08790	ENOG4107RE3	peptidase, S41
RPIT_08800	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
RPIT_08805	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
RPIT_08810	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
RPIT_08815	ENOG4105DSF	transport protein
RPIT_08820	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
RPIT_08855	ENOG4105I1K	ABC transporter
RPIT_08875	ENOG4108NZE	NAGC-like transcriptional regulator
RPIT_08880	ENOG4105CSV	Glutaminase
RPIT_08920	ENOG4105HHS	UPF0256 protein
RPIT_08925	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
RPIT_08940	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
RPIT_08945	ENOG4105CXT	aspartate transcarbamylase
RPIT_08950	ENOG4105CD3	dihydroorotase
RPIT_08955	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
RPIT_08960	ENOG4107QRT	dEAD DEAH box helicase
RPIT_08965	ENOG4108S0J	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity)
RPIT_08970	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_08975	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
RPIT_09000	ENOG4105CQB	FAD linked oxidase domain protein
RPIT_09005	ENOG4105EMN	RNA polymerase sigma factor
RPIT_09060	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
RPIT_09110	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
RPIT_09195	ENOG4105CJP	fad dependent oxidoreductase
RPIT_09210	ENOG4105K63	Thioredoxin
RPIT_09295	ENOG4107XZA	Glycosyl transferase family 2
RPIT_09305	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
RPIT_09340	ENOG4107QMH	DNA methylase
RPIT_09415	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
RPIT_09425	ENOG4105NAF	rna polymerase sigma factor
RPIT_09450	ENOG4105K59	histidine triad (HIT) protein
RPIT_09475	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
RPIT_09490	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
RPIT_09495	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
RPIT_09500	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
RPIT_09505	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
RPIT_09515	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
RPIT_09545	ENOG4105CNH	Multidrug resistance protein MdtL
RPIT_09560	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
RPIT_09570	ENOG4105W49	UPF0434 protein
RPIT_09600	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
RPIT_09625	ENOG4108KGH	TRANSCRIPTIONal
RPIT_09630	ENOG4108KGH	TRANSCRIPTIONal
RPIT_09655	ENOG4105D8K	carboxyl transferase
RPIT_09665	ENOG4107WR6	Maf-like protein
RPIT_09680	ENOG4105PTV	Nudix Hydrolase
RPIT_09685	ENOG4108JIK	carboxylase
RPIT_09695	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
RPIT_09710	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
RPIT_09730	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
RPIT_09740	ENOG4105WH1	Two component transcriptional regulator luxr family
RPIT_09755	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
RPIT_09775	ENOG4105UIB	(ABC) transporter
RPIT_09780	ENOG4108JQ9	ABC transporter
RPIT_09785	ENOG4107TFB	basic membrane
RPIT_09815	ENOG4107QN1	sodium solute
RPIT_09820	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
RPIT_09840	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
RPIT_09845	ENOG4105DC1	bifunctional purine biosynthesis protein purh
RPIT_09870	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
RPIT_09885	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
RPIT_09900	ENOG4105WH1	Two component transcriptional regulator luxr family
RPIT_09925	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
RPIT_09945	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
RPIT_09950	ENOG4107QVP	Dehydrogenase
RPIT_09965	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
RPIT_09970	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
RPIT_09975	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
RPIT_09980	ENOG4108UW5	maltose o-acetyltransferase
RPIT_09990	ENOG4105P4J	Allophanate hydrolase, subunit 1
RPIT_09995	ENOG4105E7W	lamb ycsf family protein
RPIT_10030	ENOG4108NY6	Extracellular solute-binding protein, family 5
RPIT_10035	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
RPIT_10040	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
RPIT_10050	ENOG4108097	ATP-binding protein
RPIT_10055	ENOG4105C1J	atp-dependent rna helicase
RPIT_10065	ENOG41080T7	secreted protein
RPIT_10080	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
RPIT_10085	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
RPIT_10090	ENOG4105CS9	pantothenic acid kinase
RPIT_10095	ENOG4107UH8	sugar kinase
RPIT_10100	ENOG4107T6F	Xaa-Pro aminopeptidase
RPIT_10110	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
RPIT_10120	ENOG4105CJW	magnesium transporter
RPIT_10140	ENOG410630M	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
RPIT_10155	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
RPIT_10165	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
RPIT_10170	ENOG4107QPH	glycogen) synthase
RPIT_10185	ENOG4108URH	decarboxylase
RPIT_10190	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
RPIT_10210	ENOG4105C72	UPF0176 protein
RPIT_10215	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
RPIT_10225	ENOG4105BZ1	(ABC) transporter
RPIT_10230	ENOG4105BZ1	(ABC) transporter
RPIT_10235	ENOG4107QX3	carboxylase
RPIT_10245	ENOG4107QSA	Oxaloacetate decarboxylase
RPIT_10250	ENOG4105D9Q	decarboxylase (Beta subunit)
RPIT_10260	ENOG4108Z4U	Ferredoxin
RPIT_10315	ENOG4108RWI	nicotinamidase
RPIT_10320	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
RPIT_10335	ENOG4105D7W	serine acetyltransferase
RPIT_10345	ENOG4108M15	ABC transporter
RPIT_10350	ENOG4105KCT	ABC transporter
RPIT_10370	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
RPIT_10385	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
RPIT_10405	ENOG4105EW9	transcriptional regulator AsnC family
RPIT_10410	ENOG4108YIQ	Alpha beta hydrolase
RPIT_10420	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
RPIT_10440	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
RPIT_10450	ENOG4105I93	response regulator
RPIT_10465	ENOG4105C3G	gtp-binding protein
RPIT_10475	ENOG4105DHS	permease protein
RPIT_10480	ENOG4105CM4	permease protein
RPIT_10485	ENOG4108IPW	abc transporter atp-binding protein
RPIT_10495	ENOG4105DFM	M18 family aminopeptidase
RPIT_10505	ENOG4105C7B	Threonine dehydratase
RPIT_10510	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
RPIT_10520	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
RPIT_10525	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
RPIT_10535	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
RPIT_10545	ENOG4108IAB	Phoh family
RPIT_10550	ENOG4105C7Z	Conserved Protein
RPIT_10560	ENOG4105T1M	mycothiol conjugate amidase mca
RPIT_10570	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
RPIT_10585	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
RPIT_10595	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
RPIT_10610	ENOG4107SET	aldo keto reductase
RPIT_10630	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
RPIT_10655	ENOG4105DZ6	Band 7 protein
RPIT_10685	ENOG4107QWG	2-Nitropropane dioxygenase
RPIT_10705	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
RPIT_10725	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
RPIT_10730	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
RPIT_10740	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
RPIT_10745	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
RPIT_10755	ENOG4105ETX	regulatoR
RPIT_10780	ENOG4105NAF	rna polymerase sigma factor
RPIT_10830	ENOG4107QY8	reductase
RPIT_10840	ENOG4107KGK	dmso reductase anchor subunit
RPIT_10860	ENOG4106H3A	restriction
RPIT_10865	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
RPIT_10890	ENOG4107QZF	nitrite reductase NADPH large subunit
RPIT_10895	ENOG4108IFG	nitrite reductase, (NAD(P)H)
RPIT_10900	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
RPIT_10905	ENOG4107QND	Nitrite extrusion protein
RPIT_10925	ENOG4108R3E	Dna-3-methyladenine glycosylase i
RPIT_10940	ENOG4108ZT1	Transcriptional regulator
RPIT_10945	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
RPIT_10950	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
RPIT_10955	ENOG4105F8V	Hydrolase, tatD family
RPIT_10980	ENOG4105C19	ABC transporter
RPIT_11000	ENOG4105C2W	permease
RPIT_11030	ENOG41080UU	5-formyltetrahydrofolate cyclo-ligase
RPIT_11045	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
RPIT_11090	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
RPIT_11095	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
RPIT_11100	ENOG4105BZ8	glutamate synthase
RPIT_11105	ENOG41080RH	Thioredoxin
RPIT_11125	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
RPIT_11140	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
RPIT_11150	ENOG4105C7N	Xanthine uracil vitamin C permease
RPIT_11165	ENOG4105VEQ	Cold shock protein
RPIT_11170	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
RPIT_11180	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
RPIT_11195	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
RPIT_11200	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
RPIT_11215	ENOG4105EIP	mannose-6-phosphate isomerase
RPIT_11240	ENOG4105C28	cystathionine
RPIT_11260	ENOG4107ZXU	DSBA oxidoreductase
RPIT_11265	ENOG4105C8N	cysteinyl-tRNA synthetase
RPIT_11275	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
RPIT_11290	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
RPIT_11295	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
RPIT_11300	ENOG4108VJ1	Transcriptional regulator (CarD family
RPIT_11315	ENOG4105BZU	Histidine kinase
RPIT_11320	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
RPIT_11325	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
RPIT_11330	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
RPIT_11335	ENOG4105C02	permease
RPIT_11345	ENOG4105M4B	Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity)
RPIT_11350	ENOG4105C0A	alcohol dehydrogenase
RPIT_11355	ENOG4107QSA	Oxaloacetate decarboxylase
RPIT_11365	ENOG4107QX3	carboxylase
RPIT_11370	ENOG4107QSA	Oxaloacetate decarboxylase
RPIT_11380	ENOG4105I82	acetyl xylan esterase
RPIT_11385	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
RPIT_11395	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
RPIT_11400	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
RPIT_11405	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_11415	ENOG4105C5I	Dehydrogenase
RPIT_11420	ENOG4105CHR	reductase
RPIT_11430	ENOG4105CPP	Dehydrogenase, E1 component
RPIT_11435	ENOG4107QN2	dihydrolipoyl dehydrogenase
RPIT_11440	ENOG4107QKR	Dehydrogenase
RPIT_11445	ENOG4105E98	transcriptional regulator DeoR family
RPIT_11455	ENOG4105CGD	Nad-dependent epimerase dehydratase
RPIT_11480	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_11485	ENOG4105DET	Rhamnulokinase
RPIT_11495	ENOG4105K2J	Transcriptional regulator
RPIT_11500	ENOG4105CNN	ABC, transporter
RPIT_11520	ENOG4105NAF	rna polymerase sigma factor
RPIT_11555	ENOG4107RCW	fructose-bisphosphate aldolase
RPIT_11590	ENOG4108V0P	LemA family
RPIT_11595	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
RPIT_11605	ENOG4105CJR	Integral membrane protein (MviN
RPIT_11630	ENOG4108HKT	sucrose-6-phosphate hydrolase
RPIT_11640	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
RPIT_11660	ENOG4105EIP	mannose-6-phosphate isomerase
RPIT_11670	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
RPIT_11690	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_11710	ENOG4105D64	Mechanosensitive ion channel
RPIT_11715	ENOG4105C4K	Nad synthetase
RPIT_11720	ENOG4108IJ8	ABC transporter
RPIT_11725	ENOG4105E90	ABC transporter
RPIT_11730	ENOG4105E90	ABC transporter
RPIT_11740	ENOG4108IJ7	Glycine betaine
RPIT_11775	ENOG4107QI1	Mate efflux family protein
RPIT_11790	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
RPIT_11800	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
RPIT_11805	ENOG4105CG3	alpha amylase, catalytic region
RPIT_11815	ENOG4105EXU	Membrane
RPIT_11825	ENOG4105D17	glycoside hydrolase, family 3 domain protein
RPIT_11840	ENOG4105DWF	phosphomethylpyrimidine kinase
RPIT_11850	ENOG4105DWF	phosphomethylpyrimidine kinase
RPIT_11855	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
RPIT_11890	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
RPIT_11895	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
RPIT_11915	ENOG4105KNI	merR family transcriptional Regulator
RPIT_11920	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
RPIT_11925	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RPIT_11930	ENOG4105CFG	Acts as a chaperone (By similarity)
RPIT_11955	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
RPIT_11960	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
RPIT_11980	ENOG4105CNN	ABC, transporter
RPIT_11990	ENOG4105DKQ	ROK family
RPIT_11995	ENOG4105C2J	ABC transporter
RPIT_12000	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_12005	ENOG4108HKT	sucrose-6-phosphate hydrolase
RPIT_12030	ENOG4105D7Z	glutathione synthase
RPIT_12050	ENOG4105GSW	
RPIT_12060	ENOG4106CKT	
RPIT_12105	ENOG4105D98	threonine synthase
RPIT_12120	ENOG41090CE	integral membrane protein
RPIT_12130	ENOG4105CEP	NADH dehydrogenase
RPIT_12140	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
RPIT_12145	ENOG4105BZU	Histidine kinase
RPIT_12165	ENOG4105CUC	YeeE YedE family protein
RPIT_12170	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
RPIT_12175	ENOG4105BZ1	(ABC) transporter
RPIT_12190	ENOG4105C87	Aminotransferase class I and II
RPIT_12195	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
RPIT_12210	ENOG4108YXG	UPF0502 protein
RPIT_12215	ENOG4105CFH	Aspartokinase
RPIT_12225	ENOG4105D7A	ATP-binding protein
RPIT_12260	ENOG4108Z6B	deaminase
RPIT_12270	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
RPIT_12280	ENOG4107SIQ	Naphthoate synthase
RPIT_12285	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
RPIT_12300	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
RPIT_12310	ENOG4108KGH	TRANSCRIPTIONal
RPIT_12330	ENOG4105D3G	Pseudouridine synthase
RPIT_12360	ENOG41079KZ	Major Facilitator Superfamily
RPIT_12365	ENOG4108KGH	TRANSCRIPTIONal
RPIT_12390	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
RPIT_12395	ENOG4105DKQ	ROK family
RPIT_12400	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
RPIT_12410	ENOG4105C3U	ABC transporter
RPIT_12420	ENOG4105DEF	Extracellular solute-binding protein, family 5
RPIT_12425	ENOG4107YCY	Transcriptional regulator
RPIT_12435	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
RPIT_12440	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
RPIT_12450	ENOG4105EB3	Histidine kinase
RPIT_12455	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
RPIT_12480	ENOG410905X	membrane-flanked domain protein
RPIT_12490	ENOG4105CJ1	ABC, transporter
RPIT_12510	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
RPIT_12515	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
RPIT_12530	ENOG41082T9	Membrane
RPIT_12535	ENOG4105EDK	PfkB domain protein
RPIT_12570	ENOG4108X07	Tetr family transcriptional regulator
RPIT_12575	ENOG4105CIG	ABC transporter
RPIT_12580	ENOG4105DIM	ABC transporter
RPIT_12590	ENOG4105CMN	Methylmalonyl-coA mutase
RPIT_12595	ENOG4105D5P	Methylmalonyl-coA mutase
RPIT_12610	ENOG4105BZU	Histidine kinase
RPIT_12615	ENOG4105WH1	Two component transcriptional regulator luxr family
RPIT_12625	ENOG4108RVA	ribokinase
RPIT_12635	ENOG4107Y2X	deaminase
RPIT_12640	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
RPIT_12645	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
RPIT_12685	ENOG4105TV9	FHA Domain-Containing protein
RPIT_12705	ENOG4105CJN	penicillin-binding protein
RPIT_12725	ENOG4105ZJT	Cell division protein CrgA
RPIT_12755	ENOG4105CS2	ec 3.2.1.21
RPIT_12760	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_12785	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
RPIT_12790	ENOG4108IYU	L-aspartate oxidase
RPIT_12800	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
RPIT_12810	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
RPIT_12830	ENOG4105CNN	ABC, transporter
RPIT_12835	ENOG4105C2J	ABC transporter
RPIT_12845	ENOG4107QKS	N-acylglucosamine 2-epimerase
RPIT_12850	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_12855	ENOG4105DE4	1-phosphofructokinase
RPIT_12860	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
RPIT_12880	ENOG4105KAK	Plasmid pRiA4b ORF-3 family protein
RPIT_12905	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
RPIT_12910	ENOG4105CSR	polyphosphate kinase 2
RPIT_12920	ENOG4105C4M	(Ubiquinol oxidase) subunit I
RPIT_12925	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
RPIT_12930	ENOG4108JJ9	ABC, transporter
RPIT_12940	ENOG4107V8I	Glycosyl transferases group 1
RPIT_12945	ENOG4105C9Q	fumarate hydratase class II
RPIT_12960	ENOG4105VPX	protein, conserved in bacteria
RPIT_12965	ENOG4105CDU	Replicative dna helicase
RPIT_13025	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
RPIT_13030	ENOG4105DCF	alanine dehydrogenase
RPIT_13050	ENOG4109050	May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG)
RPIT_13065	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
RPIT_13085	ENOG4108TV1	Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity)
RPIT_13100	ENOG4105BZ4	penicillin-binding protein
RPIT_13105	ENOG4105D8X	mechanosensitive ion channel
RPIT_13110	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
RPIT_13120	ENOG4105D9P	serine threonine protein kinase
RPIT_13145	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
RPIT_13150	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
RPIT_13160	ENOG4105EYF	MMPL domain protein
RPIT_13165	ENOG4108IG5	Transcriptional regulator
RPIT_13175	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
RPIT_13200	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
RPIT_13205	ENOG4108XDN	Transcriptional regulator
RPIT_13230	ENOG4105KPY	Small multidrug resistance protein
RPIT_13235	ENOG41080TC	multidrug resistance protein
RPIT_13240	ENOG4107WGA	YidE YbjL
RPIT_13245	ENOG4105DEN	Luciferase family
RPIT_13250	ENOG4105VMP	Transcriptional regulator
RPIT_13260	ENOG4105ETE	Transcriptional regulator (LacI family
RPIT_13275	ENOG4105CMG	Carbohydrate kinase
RPIT_13280	ENOG4105CNN	ABC, transporter
RPIT_13285	ENOG4105C2J	ABC transporter
RPIT_13290	ENOG4105FDP	GntR family transcriptional regulator
RPIT_13295	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
RPIT_13325	ENOG4105MC2	DSBA oxidoreductase
RPIT_13330	ENOG4108IYC	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
RPIT_13345	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
RPIT_13375	ENOG4105CKW	Inner membrane protein yedI
RPIT_13380	ENOG4105CPC	Aldo Keto reductase
RPIT_13385	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
RPIT_13395	ENOG4105EYF	MMPL domain protein
RPIT_13415	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
RPIT_13420	ENOG4107R3N	Filamentation induced by cAMP protein fic
RPIT_13470	ENOG4107SID	ATP-dependent exodnase (exonuclease v)
RPIT_13495	ENOG4107R16	Multicopper oxidase
RPIT_13515	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
RPIT_13520	ENOG4107RHR	regulatoR
RPIT_13530	ENOG4105C3M	thioredoxin reductase
RPIT_13535	ENOG4105K63	Thioredoxin
RPIT_13545	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
RPIT_13550	ENOG4105CPF	Cell wall formation (By similarity)
RPIT_13570	ENOG4107QJE	Chromosome Partitioning Protein
RPIT_13575	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
RPIT_13585	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
RPIT_13590	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
RPIT_13600	ENOG41084CH	50S ribosomal protein l34
RPIT_13605	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
RPIT_13610	ENOG4105VPX	protein, conserved in bacteria
RPIT_13620	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
RPIT_13625	ENOG4105C19	ABC transporter
RPIT_13635	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
RPIT_13645	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
RPIT_13670	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
RPIT_13675	ENOG4108ZED	Transmembrane domain of unknown function (DUF3566)
RPIT_13685	ENOG4107R3N	Filamentation induced by cAMP protein fic
RPIT_13700	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
RPIT_13720	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
RPIT_13730	ENOG4105CE1	Ferrous iron transport protein b
RPIT_13750	ENOG4107ZXI	Rhomboid family
RPIT_13760	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
RPIT_13765	ENOG4105D3Q	Sugar transferase
RPIT_13785	ENOG4107YJ4	chain length determinant protein
RPIT_13795	ENOG4107BJW	polysaccharide deacetylase
RPIT_13805	ENOG4105CPK	Glycosyl transferase (Group 1
RPIT_13820	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
RPIT_13835	ENOG4105K64	Glycosyl transferase, family 2
RPIT_13840	ENOG4108SHN	Glycosyl transferase, family 2
RPIT_13855	ENOG4105K64	Glycosyl transferase, family 2
RPIT_13860	ENOG4107QRS	glycosyltransferase group 2 family protein
RPIT_13870	ENOG4108IUS	Transketolase
RPIT_13875	ENOG4108HHA	Transketolase
RPIT_13880	ENOG4108FN7	Aldo keto reductase
RPIT_13885	ENOG4105D3Q	Sugar transferase
RPIT_13915	ENOG4105K64	Glycosyl transferase, family 2
RPIT_13920	ENOG4108JQ1	Dehydrogenase
RPIT_14025	ENOG4105BZ1	(ABC) transporter
RPIT_14040	ENOG4107QQG	Dehydrogenase
RPIT_14090	ENOG4107GFK	fumarate
RPIT_14100	ENOG4107SVN	transposase
RPIT_14105	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
RPIT_14110	ENOG4105GR3	Histidine kinase
RPIT_14115	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
RPIT_14135	ENOG4105IJJ	transcriptional regulator, crp fnr family
RPIT_14150	ENOG4105BZ1	(ABC) transporter
RPIT_14160	ENOG4105CAH	Chromate
RPIT_14185	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
RPIT_14190	ENOG4108YYH	Nadph-dependent fmn reductase
RPIT_14195	ENOG4105EJQ	L-serine dehydratase
RPIT_14255	ENOG4105CM2	brancheD-chain amino acid aminotransferase
RPIT_14265	ENOG4108UZX	fmn reductase
RPIT_14280	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
RPIT_14325	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
RPIT_14345	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
RPIT_14375	ENOG4105C8J	)-transporter
RPIT_14380	ENOG4105D1Q	UPF0246 protein
RPIT_14390	ENOG4107QKS	N-acylglucosamine 2-epimerase
RPIT_14400	ENOG4105CEY	Amp-dependent synthetase and ligase
RPIT_14405	ENOG4105EMU	Dehydrogenase
RPIT_14415	ENOG4107SVN	transposase
RPIT_14420	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
RPIT_14440	ENOG4105DEN	Luciferase family
RPIT_14445	ENOG4105KJM	monovalent cation h antiporter subunit g
RPIT_14455	ENOG4105SC1	monovalent cation H antiporter subunit E
RPIT_14460	ENOG4108JPZ	Monovalent cation H antiporter subunit D
RPIT_14465	ENOG4105MKQ	Monovalent cation H antiporter subunit C
RPIT_14470	ENOG4105D65	subunit l
RPIT_14480	ENOG4108IQE	Amp-dependent synthetase and ligase
RPIT_14490	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
RPIT_14500	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
RPIT_14510	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
RPIT_14515	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
RPIT_14540	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
RPIT_14545	ENOG4105VR1	Pfam:DUF1271
RPIT_14565	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
RPIT_14570	ENOG410904N	short-chain dehydrogenase reductase
RPIT_14580	ENOG4105FEU	K -dependent Na -Ca exchanger
RPIT_14595	ENOG4108C33	Resolvase
RPIT_14600	ENOG4108R0M	Aminoglycoside
RPIT_14630	ENOG4107QJE	Chromosome Partitioning Protein
RPIT_14645	ENOG4108C33	Resolvase
RPIT_14685	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
RPIT_14715	ENOG4108JQ7	(ABC) transporter
RPIT_14720	ENOG4105C3U	ABC transporter
RPIT_14725	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
RPIT_14730	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
RPIT_14735	ENOG4108J59	Extracellular solute-binding protein, family 5
RPIT_14750	ENOG41085FC	arsR family transcriptional regulator
RPIT_14780	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
RPIT_14785	ENOG4108Z6Z	Transcriptional regulator
RPIT_14805	ENOG4105CMR	udp-glucose 4-epimerase
RPIT_14870	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
RPIT_14875	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase