locus-tag	class	description
KV134_00010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KV134_00015	COG3344	reverse transcriptase
KV134_00035	COG0745	RESPONSE REGULATOR receiver
KV134_00050	COG2205	protein histidine kinase activity
KV134_00060	COG1028	Short-chain dehydrogenase reductase Sdr
KV134_00065	COG1464	Belongs to the NlpA lipoprotein family
KV134_00085	COG0693	protein deglycase activity
KV134_00090	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KV134_00095	COG3414	Phosphotransferase system galactitol-specific IIB component
KV134_00100	COG3775	system Galactitol-specific IIC component
KV134_00120	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KV134_00130	COG1705	Flagellar rod assembly protein muramidase FlgJ
KV134_00130	COG1388	LysM domain
KV134_00135	COG0495	leucyl-tRNA aminoacylation
KV134_00140	COG1764	response to oxidative stress
KV134_00150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KV134_00155	COG2244	polysaccharide biosynthetic process
KV134_00160	COG1187	pseudouridine synthase activity
KV134_00165	COG0564	pseudouridine synthase activity
KV134_00170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KV134_00175	COG3679	Belongs to the UPF0342 family
KV134_00180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KV134_00185	COG0315	cyclic pyranopterin monophosphate synthase activity
KV134_00200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KV134_00225	COG0746	molybdenum cofactor guanylyltransferase activity
KV134_00230	COG2116	formate transmembrane transporter activity
KV134_00250	COG3383	formate dehydrogenase (NAD+) activity
KV134_00255	COG0303	'Molybdopterin
KV134_00260	COG0303	'Molybdopterin
KV134_00280	COG3481	metal-dependent phosphohydrolase, HD sub domain
KV134_00285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KV134_00295	COG0537	adenosine 5'-monophosphoramidase activity
KV134_00310	COG1482	cell wall glycoprotein biosynthetic process
KV134_00320	COG1263	PTS System
KV134_00320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_00320	COG2190	(PTS) system
KV134_00325	COG3442	glutamine amidotransferase
KV134_00330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KV134_00340	COG0681	Belongs to the peptidase S26 family
KV134_00350	COG0071	Belongs to the small heat shock protein (HSP20) family
KV134_00365	COG1435	thymidine kinase activity
KV134_00375	COG2890	protein-(glutamine-N5) methyltransferase activity
KV134_00385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KV134_00390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KV134_00405	COG0772	Belongs to the SEDS family
KV134_00410	COG1393	Belongs to the ArsC family
KV134_00420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KV134_00425	COG0572	uridine kinase
KV134_00445	COG1181	Belongs to the D-alanine--D-alanine ligase family
KV134_00450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KV134_00460	COG0736	holo-[acyl-carrier-protein] synthase activity
KV134_00465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KV134_00470	COG2337	Toxic component of a toxin-antitoxin (TA) module
KV134_00480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KV134_00505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KV134_00515	COG0343	queuine tRNA-ribosyltransferase activity
KV134_00525	COG1304	FMN binding
KV134_00540	COG0083	homoserine kinase activity
KV134_00545	COG1428	Deoxynucleoside kinase
KV134_00550	COG0446	pyridine nucleotide-disulphide oxidoreductase
KV134_00555	COG0402	S-adenosylhomocysteine deaminase activity
KV134_00560	COG0402	S-adenosylhomocysteine deaminase activity
KV134_00580	COG2508	Transcriptional regulator
KV134_00585	COG4166	transmembrane transport
KV134_00590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KV134_00595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KV134_00600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KV134_00610	COG0824	Thioesterase
KV134_00615	COG0124	histidyl-tRNA synthetase
KV134_00625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KV134_00640	COG1459	type II secretion system
KV134_00645	COG4537	Required for transformation and DNA binding
KV134_00675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KV134_00695	COG1363	Peptidase, m42
KV134_00700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KV134_00705	COG0589	response to stress
KV134_00710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KV134_00715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KV134_00730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KV134_00745	COG0322	excinuclease ABC activity
KV134_00760	COG0492	ferredoxin-NADP+ reductase activity
KV134_00765	COG1846	Transcriptional regulator
KV134_00770	COG0386	Belongs to the glutathione peroxidase family
KV134_00775	COG3118	belongs to the thioredoxin family
KV134_00785	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KV134_00790	COG0446	pyridine nucleotide-disulphide oxidoreductase
KV134_00795	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KV134_00810	COG2188	Transcriptional regulator
KV134_00815	COG2222	sugar isomerase
KV134_00835	COG0702	epimerase
KV134_00845	COG2217	Heavy metal translocating P-type atpase
KV134_00855	COG1285	pathogenesis
KV134_00870	COG1269	ATP hydrolysis coupled proton transport
KV134_00875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KV134_00880	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
KV134_00895	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
KV134_00905	COG1394	ATPase activity, coupled to movement of substances
KV134_00910	COG1073	alpha beta
KV134_00915	COG1054	Belongs to the UPF0176 family
KV134_00950	COG1695	Transcriptional regulator
KV134_00955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KV134_00960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KV134_00975	COG0488	(ABC) transporter
KV134_00980	COG0577	efflux transmembrane transporter activity
KV134_00980	COG0577	efflux transmembrane transporter activity
KV134_00980	COG1136	(ABC) transporter
KV134_00980	COG1136	(ABC) transporter
KV134_00990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KV134_01010	COG2188	Transcriptional regulator
KV134_01015	COG3448	diguanylate cyclase activity
KV134_01015	COG4175	Glycine betaine
KV134_01040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KV134_01045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KV134_01055	COG0471	metal ion transport
KV134_01075	COG0363	glucosamine-6-phosphate deaminase activity
KV134_01085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KV134_01090	COG4109	DRTGG domain
KV134_01095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KV134_01115	COG1028	Short-chain dehydrogenase reductase Sdr
KV134_01120	COG3001	Fructosamine kinase
KV134_01130	COG0531	amino acid
KV134_01135	COG1082	Xylose isomerase domain protein TIM barrel
KV134_01140	COG1053	succinate dehydrogenase
KV134_01170	COG0084	hydrolase, TatD family'
KV134_01175	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KV134_01180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KV134_01200	COG1288	antiporter activity
KV134_01205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KV134_01210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KV134_01215	COG1472	Belongs to the glycosyl hydrolase 3 family
KV134_01240	COG4175	Glycine betaine
KV134_01240	COG3448	diguanylate cyclase activity
KV134_01255	COG5039	Polysaccharide pyruvyl transferase
KV134_01260	COG2261	transglycosylase associated protein
KV134_01275	COG2249	NAD(P)H dehydrogenase (quinone) activity
KV134_01290	COG0716	FMN binding
KV134_01295	COG0628	permease
KV134_01300	COG1705	Flagellar rod assembly protein muramidase FlgJ
KV134_01300	COG3942	CHAP domain
KV134_01320	COG3764	Sortase (surface protein transpeptidase)
KV134_01340	COG1316	TRANSCRIPTIONal
KV134_01345	COG3944	biosynthesis protein
KV134_01350	COG0489	protein tyrosine kinase activity
KV134_01355	COG4464	protein tyrosine phosphatase activity
KV134_01385	COG1216	Glycosyl transferase, family 2
KV134_01385	COG0463	Glycosyl transferase, family 2
KV134_01390	COG0438	transferase activity, transferring glycosyl groups
KV134_01410	COG1045	serine acetyltransferase
KV134_01435	COG0438	transferase activity, transferring glycosyl groups
KV134_01440	COG3385	transposase activity
KV134_01525	COG3385	transposase activity
KV134_01550	COG0210	DNA helicase
KV134_01565	COG4584	PFAM Integrase catalytic
KV134_01565	COG2390	Transcriptional regulator
KV134_01635	COG2433	Pfam Transposase IS66
KV134_01650	COG2433	Pfam Transposase IS66
KV134_01655	COG1263	PTS System
KV134_01655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_01655	COG2190	(PTS) system
KV134_01660	COG2190	(PTS) system
KV134_01660	COG1263	PTS System
KV134_01660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_01690	COG3711	transcriptional antiterminator
KV134_01700	COG1263	PTS System
KV134_01700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_01700	COG2190	(PTS) system
KV134_01705	COG2002	toxin-antitoxin pair type II binding
KV134_01730	COG3177	Filamentation induced by cAMP protein fic
KV134_01780	COG3414	Phosphotransferase system galactitol-specific IIB component
KV134_01785	COG3775	system Galactitol-specific IIC component
KV134_01795	COG4213	ABC transporter substrate-binding protein
KV134_01845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KV134_01850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KV134_01855	COG0246	Mannitol dehydrogenase
KV134_02000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KV134_02020	COG0783	Belongs to the Dps family
KV134_02025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KV134_02040	COG2217	Heavy metal translocating P-type atpase
KV134_02095	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
KV134_02145	COG2113	Glycine betaine
KV134_02150	COG1510	regulation of RNA biosynthetic process
KV134_02155	COG1012	belongs to the aldehyde dehydrogenase family
KV134_02160	COG1012	belongs to the aldehyde dehydrogenase family
KV134_02165	COG1012	belongs to the aldehyde dehydrogenase family
KV134_02235	COG2814	Major facilitator Superfamily
KV134_02245	COG3711	transcriptional antiterminator
KV134_02245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_02275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KV134_02295	COG1349	DNA-binding transcription factor activity
KV134_02300	COG2723	6-phospho-beta-galactosidase activity
KV134_02305	COG1263	PTS System
KV134_02305	COG2190	(PTS) system
KV134_02305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_02310	COG2188	Transcriptional regulator
KV134_02320	COG0405	Gamma-glutamyltransferase
KV134_02340	COG2376	Dihydroxyacetone kinase
KV134_02355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KV134_02360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KV134_02370	COG3835	regulator
KV134_02390	COG0668	transmembrane transport
KV134_02440	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KV134_02455	COG2190	(PTS) system
KV134_02455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_02455	COG1263	PTS System
KV134_02460	COG2723	6-phospho-beta-galactosidase activity
KV134_02465	COG3711	transcriptional antiterminator
KV134_02480	COG1131	(ABC) transporter
KV134_02485	COG1131	(ABC) transporter
KV134_02500	COG2252	PERMEase
KV134_02505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KV134_02510	COG2217	Heavy metal translocating P-type atpase
KV134_02540	COG3711	transcriptional antiterminator
KV134_02550	COG1063	alcohol dehydrogenase
KV134_02560	COG1063	alcohol dehydrogenase
KV134_02565	COG1070	Carbohydrate kinase
KV134_02570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_02575	COG3715	PTS system
KV134_02580	COG3716	PTS system mannose fructose sorbose family IID component
KV134_02595	COG3069	C4-dicarboxylate transmembrane transporter activity
KV134_02605	COG2188	Transcriptional regulator
KV134_02615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KV134_02620	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KV134_02625	COG2390	Transcriptional regulator
KV134_02630	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KV134_02635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KV134_02640	COG0583	DNA-binding transcription factor activity
KV134_02675	COG3344	reverse transcriptase
KV134_02680	COG4720	Psort location CytoplasmicMembrane, score
KV134_02700	COG2190	(PTS) system
KV134_02700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_02700	COG1263	PTS System
KV134_02710	COG2188	Transcriptional regulator
KV134_02720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_02720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_02720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_02725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_02730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_02735	COG0800	Aldolase
KV134_02740	COG0149	triose-phosphate isomerase activity
KV134_02745	COG1609	Transcriptional regulator
KV134_02775	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KV134_02785	COG2390	Transcriptional regulator
KV134_02795	COG0657	acetylesterase activity
KV134_02795	COG2755	lipolytic protein G-D-S-L family
KV134_02815	COG4297	protein containing double-stranded beta helix domain
KV134_02845	COG1012	belongs to the aldehyde dehydrogenase family
KV134_02845	COG1454	alcohol dehydrogenase
KV134_02860	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KV134_02910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_02915	COG3414	Phosphotransferase system galactitol-specific IIB component
KV134_02920	COG3775	system Galactitol-specific IIC component
KV134_02925	COG0235	Class ii aldolase
KV134_02940	COG3715	PTS system
KV134_02950	COG2222	sugar isomerase
KV134_02955	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KV134_02955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KV134_02960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KV134_02965	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KV134_02970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KV134_02975	COG2233	PERMEase
KV134_02985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KV134_02990	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KV134_02995	COG1120	ATPase activity
KV134_03000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KV134_03005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KV134_03010	COG3344	reverse transcriptase
KV134_03015	COG0477	Major facilitator Superfamily
KV134_03020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KV134_03025	COG0492	ferredoxin-NADP+ reductase activity
KV134_03035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KV134_03040	COG1098	S1 RNA binding domain
KV134_03125	COG2190	(PTS) system
KV134_03140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KV134_03150	COG1882	Formate acetyltransferase
KV134_03160	COG5504	Zn-dependent protease
KV134_03165	COG0251	oxidation-reduction process
KV134_03170	COG1464	Belongs to the NlpA lipoprotein family
KV134_03180	COG1263	PTS System
KV134_03180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_03190	COG1349	DNA-binding transcription factor activity
KV134_03195	COG1482	cell wall glycoprotein biosynthetic process
KV134_03205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KV134_03210	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KV134_03220	COG4221	oxidoreductase activity
KV134_03240	COG0656	L-ascorbic acid biosynthetic process
KV134_03250	COG2133	pyrroloquinoline quinone binding
KV134_03255	COG0789	Transcriptional regulator
KV134_03260	COG0656	L-ascorbic acid biosynthetic process
KV134_03270	COG3425	synthase
KV134_03290	COG0741	lytic transglycosylase activity
KV134_03300	COG0358	DNA primase activity
KV134_03305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KV134_03330	COG0735	belongs to the Fur family
KV134_03335	COG4974	Belongs to the 'phage' integrase family
KV134_03345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KV134_03350	COG1187	pseudouridine synthase activity
KV134_03355	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KV134_03360	COG1141	Ferredoxin
KV134_03370	COG0514	ATP-dependent DNA helicase (RecQ)
KV134_03390	COG0539	negative regulation of cytoplasmic translation
KV134_03395	COG1160	GTP binding
KV134_03400	COG0776	regulation of translation
KV134_03410	COG0457	Tetratricopeptide repeat
KV134_03415	COG5582	Belongs to the UPF0302 family
KV134_03420	COG1694	Mazg nucleotide pyrophosphohydrolase
KV134_03425	COG0617	tRNA 3'-terminal CCA addition
KV134_03445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KV134_03465	COG1940	carbohydrate kinase activity
KV134_03470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KV134_03485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KV134_03490	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KV134_03495	COG1609	Transcriptional regulator
KV134_03500	COG0110	maltose O-acetyltransferase activity
KV134_03525	COG1214	PFAM Peptidase M22, glycoprotease
KV134_03540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KV134_03545	COG0052	Belongs to the universal ribosomal protein uS2 family
KV134_03550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KV134_03555	COG0528	UMP kinase activity
KV134_03560	COG0233	cytoplasmic translational termination
KV134_03565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KV134_03570	COG4589	Belongs to the CDS family
KV134_03575	COG0750	zinc metalloprotease
KV134_03580	COG0442	prolyl-tRNA aminoacylation
KV134_03600	COG3557	Belongs to the UPF0374 family
KV134_03610	COG1253	flavin adenine dinucleotide binding
KV134_03615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KV134_03625	COG0542	response to heat
KV134_03635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_03640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KV134_03660	COG0438	transferase activity, transferring glycosyl groups
KV134_03665	COG2084	Dehydrogenase
KV134_03670	COG4703	Protein of unknown function (DUF1797)
KV134_03675	COG1428	Deoxynucleoside kinase
KV134_03690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KV134_03695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KV134_03700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KV134_03705	COG1028	Short-chain dehydrogenase reductase Sdr
KV134_03715	COG0511	ligase activity, forming carbon-carbon bonds
KV134_03720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KV134_03725	COG0439	Biotin carboxylase
KV134_03730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KV134_03735	COG0825	malonyl-CoA metabolic process
KV134_03740	COG1607	acyl-coa hydrolase
KV134_03760	COG4152	abc transporter atp-binding protein
KV134_03765	COG1668	transmembrane transport
KV134_03770	COG2084	Dehydrogenase
KV134_03775	COG0583	DNA-binding transcription factor activity
KV134_03780	COG2855	membrane
KV134_03790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KV134_03830	COG1373	ATPase (AAA superfamily
KV134_03835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KV134_03840	COG0765	amino acid transport
KV134_03875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KV134_03895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KV134_03905	COG3414	Phosphotransferase system galactitol-specific IIB component
KV134_03910	COG3775	system Galactitol-specific IIC component
KV134_03935	COG4684	Psort location CytoplasmicMembrane, score
KV134_03940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KV134_03950	COG0604	alcohol dehydrogenase
KV134_03955	COG0346	lactoylglutathione lyase activity
KV134_03965	COG0488	(ABC) transporter
KV134_03970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KV134_03975	COG4472	Bacterial protein of unknown function (DUF965)
KV134_03985	COG3906	Belongs to the UPF0473 family
KV134_03990	COG1464	Belongs to the NlpA lipoprotein family
KV134_04000	COG3448	diguanylate cyclase activity
KV134_04000	COG4175	Glycine betaine
KV134_04025	COG2059	Chromate
KV134_04060	COG3118	belongs to the thioredoxin family
KV134_04070	COG0346	lactoylglutathione lyase activity
KV134_04080	COG1078	dGTPase activity
KV134_04085	COG0095	Lipoate-protein ligase
KV134_04115	COG2390	Transcriptional regulator
KV134_04125	COG0126	phosphoglycerate kinase activity
KV134_04130	COG0149	triose-phosphate isomerase activity
KV134_04135	COG0148	phosphopyruvate hydratase activity
KV134_04140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KV134_04150	COG0557	exoribonuclease II activity
KV134_04155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KV134_04165	COG0356	it plays a direct role in the translocation of protons across the membrane
KV134_04170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KV134_04175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KV134_04180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KV134_04185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KV134_04225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KV134_04250	COG2188	Transcriptional regulator
KV134_04255	COG1739	Uncharacterized protein family UPF0029
KV134_04265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KV134_04270	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KV134_04285	COG0653	protein targeting
KV134_04295	COG2884	Cell division ATP-binding protein ftsE
KV134_04300	COG2177	Part of the ABC transporter FtsEX involved in
KV134_04315	COG0573	inorganic phosphate transmembrane transporter activity
KV134_04320	COG0581	inorganic phosphate transmembrane transporter activity
KV134_04330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KV134_04350	COG1950	PFAM Membrane protein of
KV134_04355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KV134_04360	COG5002	protein histidine kinase activity
KV134_04365	COG0745	RESPONSE REGULATOR receiver
KV134_04395	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KV134_04400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KV134_04405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KV134_04410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KV134_04435	COG1609	Transcriptional regulator
KV134_04455	COG3775	system Galactitol-specific IIC component
KV134_04470	COG1028	Short-chain dehydrogenase reductase Sdr
KV134_04495	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KV134_04500	COG0656	L-ascorbic acid biosynthetic process
KV134_04505	COG3763	UPF0154 protein
KV134_04520	COG0561	phosphatase activity
KV134_04530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KV134_04535	COG0640	Transcriptional regulator
KV134_04545	COG0083	homoserine kinase activity
KV134_04550	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KV134_04555	COG0735	belongs to the Fur family
KV134_04560	COG4536	flavin adenine dinucleotide binding
KV134_04565	COG1732	Glycine betaine
KV134_04570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KV134_04575	COG1610	YqeY-like protein
KV134_04580	COG1702	phosphate starvation-inducible protein PhoH
KV134_04590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KV134_04595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KV134_04600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KV134_04605	COG1381	Involved in DNA repair and RecF pathway recombination
KV134_04610	COG0752	glycyl-tRNA synthetase alpha subunit
KV134_04615	COG0751	glycine-tRNA ligase activity
KV134_04630	COG1254	Belongs to the acylphosphatase family
KV134_04635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KV134_04655	COG1686	Belongs to the peptidase S11 family
KV134_04670	COG0673	inositol 2-dehydrogenase activity
KV134_04675	COG0513	Belongs to the DEAD box helicase family
KV134_04685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KV134_04690	COG1447	Phosphotransferase system cellobiose-specific component IIA
KV134_04740	COG1396	sequence-specific DNA binding
KV134_04780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KV134_04820	COG2217	Heavy metal translocating P-type atpase
KV134_04825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KV134_04835	COG1278	Cold shock
KV134_04840	COG1199	ATP-dependent helicase activity
KV134_04840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KV134_04850	COG0436	Aminotransferase
KV134_04865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KV134_04905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KV134_04905	COG0463	Glycosyl transferase, family 2
KV134_04950	COG1215	transferase activity, transferring glycosyl groups
KV134_04950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KV134_04985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KV134_04990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KV134_05000	COG4585	Histidine kinase
KV134_05005	COG2197	response regulator
KV134_05010	COG0569	domain protein
KV134_05015	COG4841	protein insertion into membrane
KV134_05025	COG1368	sulfuric ester hydrolase activity
KV134_05040	COG5521	maltodextrose utilization protein MalA
KV134_05055	COG2246	polysaccharide biosynthetic process
KV134_05065	COG2246	polysaccharide biosynthetic process
KV134_05070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KV134_05080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KV134_05085	COG1134	teichoic acid transport
KV134_05090	COG1682	transport, permease protein
KV134_05095	COG1316	TRANSCRIPTIONal
KV134_05100	COG0768	penicillin binding
KV134_05110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KV134_05130	COG1272	protein, Hemolysin III
KV134_05135	COG0371	Dehydrogenase
KV134_05140	COG1307	EDD domain protein, DegV family
KV134_05145	COG2755	lipolytic protein G-D-S-L family
KV134_05150	COG4698	Protein conserved in bacteria
KV134_05160	COG4479	Belongs to the UPF0346 family
KV134_05165	COG3409	Peptidoglycan-binding domain 1 protein
KV134_05165	COG0793	Belongs to the peptidase S41A family
KV134_05170	COG0681	Belongs to the peptidase S26 family
KV134_05175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KV134_05205	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KV134_05210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KV134_05215	COG0758	DNA mediated transformation
KV134_05230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KV134_05235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KV134_05250	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KV134_05255	COG1832	CoA-binding protein
KV134_05265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KV134_05275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KV134_05280	COG1227	inorganic diphosphatase activity
KV134_05290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KV134_05295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KV134_05300	COG3385	transposase activity
KV134_05315	COG0436	Aminotransferase
KV134_05345	COG1876	peptidase activity
KV134_05360	COG3275	phosphorelay sensor kinase activity
KV134_05365	COG3279	Response regulator of the LytR AlgR family
KV134_05370	COG1966	Carbon starvation protein
KV134_05375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KV134_05380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KV134_05385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KV134_05390	COG4989	oxidoreductase activity
KV134_05395	COG0516	GMP reductase activity
KV134_05430	COG4476	Belongs to the UPF0223 family
KV134_05435	COG0483	inositol monophosphate 1-phosphatase activity
KV134_05440	COG1217	gtp-binding protein TYPA
KV134_05445	COG4838	Belongs to the UPF0358 family
KV134_05470	COG4471	UPF0298 protein
KV134_05475	COG0742	ribosomal rna small subunit methyltransferase
KV134_05480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KV134_05485	COG3480	Lon protease (S16) C-terminal proteolytic domain
KV134_05505	COG2183	response to ionizing radiation
KV134_05510	COG3091	SprT-like family
KV134_05515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KV134_05540	COG0237	dephospho-CoA kinase activity
KV134_05545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KV134_05555	COG1484	DNA-dependent DNA replication
KV134_05565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KV134_05595	COG0481	GTPase activity
KV134_05615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KV134_05635	COG2365	Tyrosine phosphatase family
KV134_05645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KV134_05665	COG0544	peptidyl-prolyl cis-trans isomerase activity
KV134_05670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KV134_05675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KV134_05685	COG1105	Belongs to the carbohydrate kinase PfkB family
KV134_05695	COG0038	chloride channel
KV134_05700	COG0210	DNA helicase
KV134_05710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KV134_05720	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KV134_05730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KV134_05745	COG5002	protein histidine kinase activity
KV134_05750	COG0745	RESPONSE REGULATOR receiver
KV134_05760	COG0702	epimerase
KV134_05770	COG0519	Catalyzes the synthesis of GMP from XMP
KV134_05785	COG0436	Aminotransferase
KV134_05795	COG1596	polysaccharide export
KV134_05795	COG1555	photosystem II stabilization
KV134_05800	COG2131	deaminase
KV134_05810	COG1466	dna polymerase III delta subunit
KV134_05815	COG0268	Binds directly to 16S ribosomal RNA
KV134_05820	COG0306	phosphate transporter
KV134_05825	COG1392	Phosphate transport regulator
KV134_05830	COG1968	undecaprenyl-diphosphatase activity
KV134_05840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KV134_05850	COG2151	metal-sulfur cluster biosynthetic enzyme
KV134_05855	COG0167	dihydroorotate dehydrogenase activity
KV134_05885	COG0446	pyridine nucleotide-disulphide oxidoreductase
KV134_05900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KV134_05920	COG1388	LysM domain
KV134_05950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KV134_05960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KV134_05965	COG0456	acetyltransferase
KV134_05985	COG2124	cytochrome p450
KV134_05990	COG1307	EDD domain protein, DegV family
KV134_06000	COG0077	Prephenate dehydratase
KV134_06005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KV134_06015	COG0287	Prephenate dehydrogenase
KV134_06020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KV134_06025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KV134_06030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KV134_06035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KV134_06045	COG4120	Belongs to the binding-protein-dependent transport system permease family
KV134_06060	COG1293	RNA-binding protein homologous to eukaryotic snRNP
KV134_06080	COG0284	orotidine-5'-phosphate decarboxylase activity
KV134_06090	COG0505	Belongs to the CarA family
KV134_06095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KV134_06115	COG0564	pseudouridine synthase activity
KV134_06120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KV134_06130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KV134_06140	COG0328	RNA-DNA hybrid ribonuclease activity
KV134_06155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KV134_06170	COG2153	protein acetylation
KV134_06175	COG0513	Belongs to the DEAD box helicase family
KV134_06190	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KV134_06205	COG1028	Short-chain dehydrogenase reductase Sdr
KV134_06215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KV134_06220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KV134_06230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KV134_06235	COG3385	transposase activity
KV134_06270	COG0116	Belongs to the methyltransferase superfamily
KV134_06280	COG3599	regulation of cell shape
KV134_06285	COG4474	Belongs to the UPF0398 family
KV134_06290	COG3331	DNA recombination
KV134_06300	COG3935	DnaD domain protein
KV134_06305	COG0735	belongs to the Fur family
KV134_06310	COG1388	LysM domain
KV134_06310	COG1705	Flagellar rod assembly protein muramidase FlgJ
KV134_06325	COG4224	UPF0291 protein
KV134_06340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KV134_06345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KV134_06345	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KV134_06350	COG5416	Lipopolysaccharide assembly protein A domain
KV134_06355	COG0300	oxidoreductase activity
KV134_06360	COG1234	tRNA 3'-trailer cleavage
KV134_06370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KV134_06385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KV134_06390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KV134_06400	COG0517	IMP dehydrogenase activity
KV134_06415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KV134_06420	COG0765	amino acid transport
KV134_06425	COG0765	amino acid transport
KV134_06430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KV134_06435	COG1126	abc transporter atp-binding protein
KV134_06440	COG0180	Tryptophanyl-tRNA synthetase
KV134_06445	COG3344	reverse transcriptase
KV134_06460	COG0072	phenylalanine-tRNA ligase activity
KV134_06460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KV134_06465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KV134_06470	COG1733	regulation of RNA biosynthetic process
KV134_06475	COG1074	ATP-dependent DNA helicase activity
KV134_06515	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KV134_06525	COG1481	regulation of sporulation
KV134_06530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KV134_06535	COG1660	Displays ATPase and GTPase activities
KV134_06540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KV134_06550	COG0765	amino acid transport
KV134_06555	COG1126	abc transporter atp-binding protein
KV134_06600	COG0196	riboflavin kinase activity
KV134_06610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KV134_06625	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KV134_06630	COG0195	Participates in both transcription termination and antitermination
KV134_06635	COG0779	Required for maturation of 30S ribosomal subunits
KV134_06640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KV134_06650	COG3189	MarR family transcriptional regulator
KV134_06675	COG3973	AAA domain
KV134_06690	COG0475	glutathione-regulated potassium exporter activity
KV134_06690	COG0569	domain protein
KV134_06700	COG0217	transcriptional regulatory protein
KV134_06710	COG1323	Belongs to the UPF0348 family
KV134_06715	COG2226	methyltransferase
KV134_06720	COG0799	negative regulation of ribosome biogenesis
KV134_06725	COG1713	HD superfamily hydrolase involved in NAD metabolism
KV134_06730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KV134_06735	COG1534	Rna-binding protein
KV134_06740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KV134_06745	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KV134_06760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KV134_06785	COG2096	Adenosyltransferase
KV134_06800	COG0165	Argininosuccinate lyase
KV134_06805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KV134_06835	COG1486	melibiose metabolic process
KV134_06850	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KV134_06855	COG2723	6-phospho-beta-galactosidase activity
KV134_06885	COG1263	PTS System
KV134_06885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_06885	COG2190	(PTS) system
KV134_06900	COG1175	transmembrane transport
KV134_06905	COG1653	transport
KV134_06930	COG3385	transposase activity
KV134_06945	COG1263	PTS System
KV134_06945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_06950	COG0366	Alpha amylase catalytic
KV134_06955	COG0366	Alpha amylase catalytic
KV134_06960	COG1609	Transcriptional regulator
KV134_06965	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KV134_06965	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KV134_07005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KV134_07015	COG0383	alpha-mannosidase activity
KV134_07025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KV134_07030	COG2188	Transcriptional regulator
KV134_07045	COG3711	transcriptional antiterminator
KV134_07080	COG1609	Transcriptional regulator
KV134_07085	COG1609	Transcriptional regulator
KV134_07090	COG1609	Transcriptional regulator
KV134_07145	COG0583	DNA-binding transcription factor activity
KV134_07150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KV134_07165	COG3716	PTS system mannose fructose sorbose family IID component
KV134_07175	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_07180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_07200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_07200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_07200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_07205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_07205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_07205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_07225	COG1454	alcohol dehydrogenase
KV134_07230	COG0235	Class ii aldolase
KV134_07235	COG4806	L-rhamnose isomerase
KV134_07240	COG1070	Carbohydrate kinase
KV134_07255	COG1063	alcohol dehydrogenase
KV134_07265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KV134_07290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_07320	COG2723	6-phospho-beta-galactosidase activity
KV134_07335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_07340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_07340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_07340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_07355	COG1929	Belongs to the glycerate kinase type-1 family
KV134_07360	COG2610	gluconate transmembrane transporter activity
KV134_07370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KV134_07390	COG0802	atpase or kinase
KV134_07395	COG0280	phosphate acetyltransferase
KV134_07405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KV134_07410	COG0561	phosphatase activity
KV134_07425	COG1780	Probably involved in ribonucleotide reductase function
KV134_07430	COG0583	DNA-binding transcription factor activity
KV134_07435	COG1368	sulfuric ester hydrolase activity
KV134_07445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KV134_07450	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KV134_07475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KV134_07490	COG5002	protein histidine kinase activity
KV134_07495	COG0745	RESPONSE REGULATOR receiver
KV134_07515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KV134_07535	COG0583	DNA-binding transcription factor activity
KV134_07545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KV134_07575	COG0561	phosphatase activity
KV134_07595	COG1447	Phosphotransferase system cellobiose-specific component IIA
KV134_07605	COG2723	6-phospho-beta-galactosidase activity
KV134_07610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_07610	COG3711	transcriptional antiterminator
KV134_07615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KV134_07630	COG0604	alcohol dehydrogenase
KV134_07650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KV134_07670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KV134_07675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KV134_07690	COG0367	asparagine synthase
KV134_07710	COG3344	reverse transcriptase
KV134_07720	COG1120	ATPase activity
KV134_07730	COG2819	hydrolase of the alpha beta superfamily
KV134_07735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KV134_07740	COG1811	Na channel or pump
KV134_07770	COG1122	ATPase activity
KV134_07780	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KV134_07805	COG0577	efflux transmembrane transporter activity
KV134_07815	COG0642	Histidine kinase
KV134_07820	COG0745	RESPONSE REGULATOR receiver
KV134_07830	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
KV134_07835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KV134_07840	COG2169	Transcriptional regulator
KV134_07845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KV134_07855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KV134_07865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KV134_07870	COG2130	NADP-dependent
KV134_07875	COG1902	pentaerythritol trinitrate reductase activity
KV134_07880	COG1733	regulation of RNA biosynthetic process
KV134_07890	COG1136	(ABC) transporter
KV134_07910	COG5002	protein histidine kinase activity
KV134_07915	COG0745	RESPONSE REGULATOR receiver
KV134_07945	COG2801	Transposase and inactivated derivatives
KV134_07980	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
KV134_07985	COG0604	alcohol dehydrogenase
KV134_07995	COG4106	trans-aconitate 2-methyltransferase activity
KV134_08035	COG0583	DNA-binding transcription factor activity
KV134_08080	COG2390	Transcriptional regulator
KV134_08115	COG0254	rRNA binding
KV134_08135	COG0504	CTP synthase activity
KV134_08145	COG0789	Transcriptional regulator
KV134_08150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KV134_08155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KV134_08160	COG0584	glycerophosphoryl diester phosphodiesterase
KV134_08170	COG0740	serine-type endopeptidase activity
KV134_08175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KV134_08180	COG1132	(ABC) transporter
KV134_08190	COG5503	Protein of unknown function (DUF1447)
KV134_08200	COG1278	Cold shock
KV134_08205	COG2003	Belongs to the UPF0758 family
KV134_08210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KV134_08215	COG0285	dihydrofolate synthase activity
KV134_08220	COG0525	valine-tRNA ligase activity
KV134_08225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KV134_08230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KV134_08240	COG1104	cysteine desulfurase activity
KV134_08245	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KV134_08255	COG3344	reverse transcriptase
KV134_08260	COG4166	transmembrane transport
KV134_08270	COG4876	unkown
KV134_08280	COG0561	phosphatase activity
KV134_08285	COG1801	Protein of unknown function DUF72
KV134_08300	COG1823	symporter activity
KV134_08310	COG3579	cysteine-type endopeptidase activity
KV134_08315	COG3594	Acyltransferase
KV134_08345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KV134_08370	COG2207	Transcriptional regulator
KV134_08380	COG1917	Cupin 2, conserved barrel domain protein
KV134_08380	COG2207	Transcriptional regulator
KV134_08385	COG0656	L-ascorbic acid biosynthetic process
KV134_08395	COG0640	Transcriptional regulator
KV134_08400	COG2814	Major facilitator Superfamily
KV134_08410	COG0693	protein deglycase activity
KV134_08415	COG2217	Heavy metal translocating P-type atpase
KV134_08435	COG0783	Belongs to the Dps family
KV134_08470	COG3549	Plasmid maintenance system killer
KV134_08485	COG2211	Major facilitator Superfamily
KV134_08520	COG0789	Transcriptional regulator
KV134_08525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KV134_08545	COG3385	transposase activity
KV134_08570	COG1073	alpha beta
KV134_08575	COG1309	transcriptional regulator
KV134_08600	COG5002	protein histidine kinase activity
KV134_08605	COG0745	RESPONSE REGULATOR receiver
KV134_08610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KV134_08630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KV134_08645	COG0205	6-phosphofructokinase activity
KV134_08660	COG2252	PERMEase
KV134_08815	COG1783	phage Terminase large subunit
KV134_08875	COG3935	DnaD domain protein
KV134_08880	COG3723	Recombinational DNA repair protein, rece pathway
KV134_08885	COG5377	YqaJ viral recombinase family
KV134_08960	COG0582	viral genome integration into host DNA
KV134_08990	COG0166	Belongs to the GPI family
KV134_08995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KV134_09000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KV134_09005	COG0710	3-dehydroquinate dehydratase activity
KV134_09010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KV134_09015	COG1368	sulfuric ester hydrolase activity
KV134_09035	COG0745	RESPONSE REGULATOR receiver
KV134_09050	COG1956	GAF domain-containing protein
KV134_09055	COG2848	UPF0210 protein
KV134_09060	COG3830	Belongs to the UPF0237 family
KV134_09070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KV134_09075	COG0336	Belongs to the RNA methyltransferase TrmD family
KV134_09105	COG3052	prosthetic group binding
KV134_09110	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
KV134_09120	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KV134_09150	COG0511	ligase activity, forming carbon-carbon bonds
KV134_09165	COG1837	Belongs to the UPF0109 family
KV134_09170	COG0228	four-way junction DNA binding
KV134_09190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KV134_09195	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KV134_09200	COG0436	Aminotransferase
KV134_09210	COG2608	mercury ion transmembrane transporter activity
KV134_09215	COG3682	Transcriptional regulator
KV134_09220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KV134_09225	COG1295	ribonuclease BN
KV134_09230	COG0024	Methionine aminopeptidase
KV134_09235	COG0716	FMN binding
KV134_09240	COG1309	transcriptional regulator
KV134_09245	COG2309	aminopeptidase activity
KV134_09255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KV134_09265	COG3599	regulation of cell shape
KV134_09270	COG2302	S4 RNA-binding domain
KV134_09275	COG0762	integral membrane protein
KV134_09280	COG1799	cell septum assembly
KV134_09285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KV134_09310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KV134_09320	COG0768	penicillin binding
KV134_09335	COG2001	Belongs to the MraZ family
KV134_09355	COG0497	DNA recombination
KV134_09360	COG1438	arginine binding
KV134_09365	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KV134_09375	COG1722	exodeoxyribonuclease VII activity
KV134_09390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KV134_09395	COG1302	Protein conserved in bacteria
KV134_09400	COG0006	proline dipeptidase activity
KV134_09410	COG4864	UPF0365 protein
KV134_09425	COG3716	PTS system mannose fructose sorbose family IID component
KV134_09430	COG3715	PTS system
KV134_09440	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_09440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV134_09460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KV134_09470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KV134_09490	COG4122	O-methyltransferase activity
KV134_09495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KV134_09500	COG0656	L-ascorbic acid biosynthetic process
KV134_09505	COG0095	Lipoate-protein ligase
KV134_09515	COG0602	queuosine metabolic process
KV134_09530	COG4467	Involved in initiation control of chromosome replication
KV134_09535	COG1774	PSP1 C-terminal conserved region
KV134_09540	COG0470	DNA polymerase III
KV134_09545	COG3870	Protein conserved in bacteria
KV134_09550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KV134_09555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KV134_09560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KV134_09565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KV134_09570	COG2723	6-phospho-beta-galactosidase activity
KV134_09585	COG0222	ribosome binding
KV134_09590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KV134_09595	COG0081	regulation of translation
KV134_09610	COG0250	Participates in transcription elongation, termination and antitermination
KV134_09615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KV134_09620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KV134_09655	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KV134_09660	COG0500	methyltransferase
KV134_09665	COG3142	Participates in the control of copper homeostasis
KV134_09680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KV134_09685	COG2357	RelA SpoT domain protein
KV134_09690	COG4116	CYTH
KV134_09705	COG4862	establishment of competence for transformation
KV134_09720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KV134_09725	COG0419	ATPase involved in DNA repair
KV134_09735	COG0420	3'-5' exonuclease activity
KV134_09740	COG0204	Acyl-transferase
KV134_09745	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KV134_09750	COG2827	Endonuclease containing a URI domain
KV134_09760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KV134_09775	COG1131	(ABC) transporter
KV134_09785	COG4658	electron transport chain
KV134_09790	COG4656	Part of a membrane complex involved in electron transport
KV134_09795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KV134_09805	COG0095	Lipoate-protein ligase
KV134_09815	COG0647	UMP catabolic process
KV134_09820	COG4470	Protein conserved in bacteria
KV134_09850	COG2738	Putative neutral zinc metallopeptidase
KV134_09860	COG0019	diaminopimelate decarboxylase activity
KV134_09865	COG1473	amidohydrolase
KV134_09870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KV134_09875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KV134_09880	COG2171	N-acyltransferase activity
KV134_09885	COG0028	Belongs to the TPP enzyme family
KV134_09895	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KV134_09895	COG0493	'glutamate synthase
KV134_09900	COG0543	2 iron, 2 sulfur cluster binding
KV134_09905	COG0716	FMN binding
KV134_09930	COG0251	oxidation-reduction process
KV134_09945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KV134_09965	COG0402	S-adenosylhomocysteine deaminase activity
KV134_09985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KV134_10030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KV134_10040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_10045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_10045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV134_10045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV134_10065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KV134_10070	COG1609	Transcriptional regulator
KV134_10075	COG1609	Transcriptional regulator
KV134_10105	COG1045	serine acetyltransferase
KV134_10120	COG0693	protein deglycase activity
KV134_10125	COG3527	Alpha-acetolactate decarboxylase
KV134_10130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KV134_10150	COG2226	methyltransferase
KV134_10170	COG1174	glycine betaine transport
KV134_10175	COG1132	(ABC) transporter
KV134_10185	COG3104	oligopeptide transport
KV134_10190	COG1428	Deoxynucleoside kinase
KV134_10200	COG1053	succinate dehydrogenase
KV134_10200	COG0431	NADPH-dependent FMN reductase
KV134_10200	COG3976	FMN-binding domain protein
KV134_10230	COG0114	fumarate hydratase activity
KV134_10255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KV134_10285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KV134_10290	COG0719	Fe-S assembly protein
KV134_10310	COG1185	polyribonucleotide nucleotidyltransferase activity
KV134_10315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KV134_10335	COG2706	6-phosphogluconolactonase activity
KV134_10340	COG0488	(ABC) transporter
KV134_10355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KV134_10355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KV134_10375	COG4608	Belongs to the ABC transporter superfamily
KV134_10390	COG0601	transmembrane transport
KV134_10410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KV134_10415	COG1674	ftsk spoiiie
KV134_10415	COG1280	lysine exporter protein (LysE YggA)
KV134_10420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KV134_10435	COG2508	Transcriptional regulator
KV134_10440	COG3842	ATPase activity
KV134_10475	COG1104	cysteine desulfurase activity
KV134_10480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KV134_10490	COG3590	peptidase
KV134_10495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KV134_10515	COG3853	Toxic anion resistance protein (TelA)
KV134_10545	COG1490	D-aminoacyl-tRNA deacylase activity
KV134_10550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KV134_10555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KV134_10560	COG2264	protein methyltransferase activity
KV134_10565	COG2094	Belongs to the DNA glycosylase MPG family
KV134_10570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KV134_10595	COG0589	response to stress
KV134_10605	COG0561	phosphatase activity
KV134_10610	COG0656	L-ascorbic acid biosynthetic process
KV134_10620	COG0656	L-ascorbic acid biosynthetic process
KV134_10625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KV134_10635	COG4473	ABC transporter
KV134_10640	COG1131	(ABC) transporter
KV134_10645	COG1132	(ABC) transporter
KV134_10660	COG0725	ABC transporter, periplasmic molybdate-binding protein
KV134_10665	COG3344	reverse transcriptase
KV134_10670	COG0521	Mo-molybdopterin cofactor biosynthetic process
KV134_10680	COG4149	molybdate abc transporter
KV134_10690	COG0242	peptide deformylase activity
KV134_10695	COG1464	Belongs to the NlpA lipoprotein family
KV134_10700	COG2011	ABC-type metal ion transport system permease component
KV134_10705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KV134_10710	COG0110	maltose O-acetyltransferase activity
KV134_10725	COG1126	abc transporter atp-binding protein
KV134_10740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KV134_10745	COG2255	four-way junction helicase activity
KV134_10800	COG4550	Control of competence regulator ComK, YlbF/YmcA
KV134_10805	COG1692	metallophosphoesterase
KV134_10820	COG0561	phosphatase activity
KV134_10835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KV134_10850	COG3279	Response regulator of the LytR AlgR family
KV134_10860	COG1268	BioY protein
KV134_10865	COG4493	Belongs to the UPF0637 family
KV134_10875	COG0519	Catalyzes the synthesis of GMP from XMP
KV134_10905	COG0552	protein localization to endoplasmic reticulum
KV134_10910	COG0561	phosphatase activity
KV134_10915	COG1196	nuclear chromosome segregation
KV134_10920	COG0571	ribonuclease III activity
KV134_10925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KV134_10930	COG0416	fatty acid biosynthetic process
KV134_10935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KV134_10940	COG1461	Dihydroxyacetone kinase
KV134_10950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KV134_10975	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KV134_11020	COG0174	glutamine synthetase
KV134_11025	COG0101	tRNA pseudouridine synthase activity
KV134_11035	COG1122	ATPase activity
KV134_11040	COG1122	ATPase activity
KV134_11045	COG0203	ribosomal protein L17
KV134_11055	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KV134_11060	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KV134_11065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KV134_11070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KV134_11075	COG0563	adenylate kinase activity
KV134_11085	COG0200	Binds to the 23S rRNA
KV134_11090	COG1841	ribosomal large subunit assembly
KV134_11095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KV134_11100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KV134_11105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KV134_11110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KV134_11115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KV134_11120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KV134_11125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KV134_11130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KV134_11135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KV134_11140	COG0255	Belongs to the universal ribosomal protein uL29 family
KV134_11150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KV134_11155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KV134_11160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KV134_11165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KV134_11170	COG0089	rRNA binding
KV134_11175	COG0088	Forms part of the polypeptide exit tunnel
KV134_11180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KV134_11185	COG0051	transcription antitermination factor activity, RNA binding
KV134_11205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KV134_11210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KV134_11215	COG0049	tRNA binding
KV134_11220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KV134_11225	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KV134_11230	COG0588	phosphoglycerate mutase activity
KV134_11235	COG1979	alcohol dehydrogenase
KV134_11245	COG0813	purine-nucleoside phosphorylase activity
KV134_11250	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KV134_11255	COG1079	Belongs to the binding-protein-dependent transport system permease family
KV134_11260	COG4603	Belongs to the binding-protein-dependent transport system permease family
KV134_11265	COG3845	ABC transporter
KV134_11270	COG1744	ABC transporter substrate-binding protein PnrA-like
KV134_11275	COG0295	cytidine deaminase activity
KV134_11280	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KV134_11285	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KV134_11290	COG1609	Transcriptional regulator
KV134_11295	COG2813	Specifically methylates the guanine in position
KV134_11300	COG1072	(Pantothenic acid kinase))
KV134_11305	COG0519	Catalyzes the synthesis of GMP from XMP
KV134_11305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KV134_11345	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KV134_11370	COG1396	sequence-specific DNA binding
KV134_11415	COG3620	sequence-specific DNA binding
KV134_11485	COG3576	pyridoxamine 5-phosphate
KV134_11495	COG3344	reverse transcriptase
KV134_11520	COG0640	Transcriptional regulator
KV134_11525	COG3385	transposase activity
KV134_11530	COG1181	Belongs to the D-alanine--D-alanine ligase family
KV134_11535	COG0708	Exodeoxyribonuclease III
KV134_11560	COG0561	phosphatase activity
KV134_11570	COG1126	abc transporter atp-binding protein
KV134_11575	COG0765	amino acid transport
KV134_11580	COG0625	glutathione transferase activity
KV134_11585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KV134_11590	COG0693	protein deglycase activity
KV134_11600	COG1694	Mazg nucleotide pyrophosphohydrolase
KV134_11610	COG2267	carboxylic ester hydrolase activity
KV134_11620	COG0789	Transcriptional regulator
KV134_11625	COG1286	toxin biosynthetic process
KV134_11655	COG0473	3-isopropylmalate dehydrogenase activity
KV134_11660	COG0471	metal ion transport
KV134_11665	COG1968	undecaprenyl-diphosphatase activity
KV134_11670	COG1388	LysM domain
KV134_11685	COG2340	Cysteine-rich secretory protein family
KV134_11690	COG1305	Transglutaminase-like
KV134_11710	COG0435	Glutathione S-transferase
KV134_11715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KV134_11720	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KV134_11755	COG1309	transcriptional regulator
KV134_11765	COG1309	transcriptional regulator
KV134_11790	COG0574	Belongs to the PEP-utilizing enzyme family
KV134_11790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KV134_11795	COG0517	IMP dehydrogenase activity
KV134_11800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KV134_11805	COG0039	L-malate dehydrogenase activity
KV134_11810	COG1737	Transcriptional regulator
KV134_11815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KV134_11830	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KV134_11845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KV134_11995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KV134_12010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KV134_12015	COG0037	tRNA processing
KV134_12020	COG1098	S1 RNA binding domain
KV134_12030	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KV134_12035	COG2244	polysaccharide biosynthetic process
KV134_12040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KV134_12045	COG0193	aminoacyl-tRNA hydrolase activity
KV134_12050	COG0039	L-malate dehydrogenase activity
KV134_12060	COG0217	transcriptional regulatory protein
KV134_12070	COG1012	belongs to the aldehyde dehydrogenase family
KV134_12080	COG2814	Major facilitator Superfamily
KV134_12090	COG1252	NADH dehydrogenase
KV134_12110	COG4166	transmembrane transport
KV134_12120	COG0803	Belongs to the bacterial solute-binding protein 9 family
KV134_12120	COG3443	Belongs to the bacterial solute-binding protein 9 family
KV134_12130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KV134_12140	COG1294	oxidase, subunit
KV134_12145	COG1271	oxidase subunit
KV134_12160	COG4975	Glucose uptake
KV134_12175	COG2153	protein acetylation
KV134_12180	COG3385	transposase activity
KV134_12205	COG1846	Transcriptional regulator
KV134_12210	COG1288	antiporter activity
KV134_12215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KV134_12220	COG0549	Belongs to the carbamate kinase family
KV134_12225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KV134_12230	COG2235	arginine
KV134_12235	COG1438	arginine binding
KV134_12245	COG3684	Belongs to the aldolase LacD family
KV134_12250	COG1105	Belongs to the carbohydrate kinase PfkB family
KV134_12280	COG1349	DNA-binding transcription factor activity
KV134_12300	COG2267	carboxylic ester hydrolase activity
KV134_12305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KV134_12310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KV134_12315	COG0783	Belongs to the Dps family
KV134_12345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KV134_12350	COG1162	GTPase activity
KV134_12430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KV134_12435	COG0516	GMP reductase activity
KV134_12435	COG0517	IMP dehydrogenase activity
KV134_12445	COG0012	GTP binding
KV134_12450	COG4481	Protein conserved in bacteria
KV134_12455	COG1475	DNA binding
KV134_12460	COG1192	Involved in chromosome partitioning
KV134_12465	COG0357	Ribosomal RNA small subunit methyltransferase G
KV134_12480	COG1442	glycosyl transferase family 8
KV134_12510	COG1304	FMN binding
KV134_12515	COG1346	cytolysis
KV134_12520	COG1380	Effector of murein hydrolase LrgA
KV134_12540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KV134_12545	COG0445	tRNA wobble uridine modification
KV134_12550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KV134_12575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KV134_12585	COG0592	DNA-directed DNA polymerase activity
KV134_12595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KV134_12600	COG0187	DNA topoisomerase II activity
KV134_12610	COG0360	Binds together with S18 to 16S ribosomal RNA
KV134_12620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KV134_12630	COG0359	binds to the 23S rRNA
KV134_12635	COG0305	Participates in initiation and elongation during chromosome replication
KV134_12645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KV134_12665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KV134_12670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KV134_12675	COG0656	L-ascorbic acid biosynthetic process
KV134_12690	COG4956	integral membrane protein (PIN domain superfamily)
KV134_12705	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KV134_12710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KV134_12715	COG3688	RNA-binding protein containing a PIN domain
KV134_12725	COG4466	Protein conserved in bacteria
KV134_12730	COG1970	mechanosensitive ion channel activity
KV134_12740	COG0612	Peptidase, M16
KV134_12745	COG0612	Peptidase, M16
KV134_12750	COG1426	Protein conserved in bacteria
KV134_12760	COG1058	Belongs to the CinA family
KV134_12760	COG1546	Belongs to the CinA family
KV134_12765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KV134_12770	COG1418	mRNA catabolic process
KV134_12775	COG2188	Transcriptional regulator
KV134_12795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KV134_12800	COG1121	(ABC) transporter
KV134_12805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KV134_12810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KV134_12815	COG0105	UTP biosynthetic process
KV134_12820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KV134_12825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KV134_12880	COG4443	Transcriptional Coactivator p15 (PC4)
KV134_12890	COG1758	RNA polymerase activity
KV134_12900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KV134_12915	COG0515	serine threonine protein kinase
KV134_12915	COG2815	serine threonine protein kinase
KV134_12920	COG4463	regulation of RNA biosynthetic process
KV134_12925	COG0542	response to heat
KV134_12935	COG0826	peptidase U32
KV134_12940	COG0826	peptidase U32
KV134_12945	COG0456	acetyltransferase
KV134_12955	COG0142	geranyltranstransferase activity