locus-tag	class	description
C7K43_00065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7K43_00070	COG4708	membrane
C7K43_00080	COG1597	lipid kinase activity
C7K43_00090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K43_00100	COG0250	Participates in transcription elongation, termination and antitermination
C7K43_00110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7K43_00115	COG0081	regulation of translation
C7K43_00120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7K43_00125	COG0222	ribosome binding
C7K43_00130	COG2910	NAD(P)H-binding
C7K43_00135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_00140	COG2723	6-phospho-beta-galactosidase activity
C7K43_00145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C7K43_00150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7K43_00155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7K43_00160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7K43_00165	COG3870	Protein conserved in bacteria
C7K43_00170	COG0470	DNA polymerase III
C7K43_00175	COG1774	PSP1 C-terminal conserved region
C7K43_00180	COG4467	Involved in initiation control of chromosome replication
C7K43_00200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C7K43_00210	COG0732	type I restriction modification DNA specificity domain
C7K43_00240	COG0602	queuosine metabolic process
C7K43_00250	COG0095	Lipoate-protein ligase
C7K43_00255	COG0656	L-ascorbic acid biosynthetic process
C7K43_00260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7K43_00280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7K43_00290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7K43_00300	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_00300	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_00305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_00305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_00315	COG3715	PTS system
C7K43_00320	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_00335	COG4864	UPF0365 protein
C7K43_00345	COG0006	proline dipeptidase activity
C7K43_00350	COG1302	Protein conserved in bacteria
C7K43_00355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K43_00360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7K43_00365	COG1570	exodeoxyribonuclease VII activity
C7K43_00370	COG1722	exodeoxyribonuclease VII activity
C7K43_00375	COG0142	geranyltranstransferase activity
C7K43_00380	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C7K43_00385	COG1438	arginine binding
C7K43_00390	COG0497	DNA recombination
C7K43_00410	COG2001	Belongs to the MraZ family
C7K43_00425	COG0768	penicillin binding
C7K43_00435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7K43_00460	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C7K43_00465	COG1799	cell septum assembly
C7K43_00470	COG0762	integral membrane protein
C7K43_00475	COG2302	S4 RNA-binding domain
C7K43_00480	COG3599	regulation of cell shape
C7K43_00485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C7K43_00490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C7K43_00500	COG2309	aminopeptidase activity
C7K43_00505	COG1309	transcriptional regulator
C7K43_00510	COG0716	FMN binding
C7K43_00515	COG0024	Methionine aminopeptidase
C7K43_00520	COG1295	ribonuclease BN
C7K43_00525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7K43_00530	COG3682	Transcriptional regulator
C7K43_00535	COG2608	mercury ion transmembrane transporter activity
C7K43_00545	COG0436	Aminotransferase
C7K43_00550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7K43_00555	COG5002	protein histidine kinase activity
C7K43_00560	COG0745	RESPONSE REGULATOR receiver
C7K43_00565	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C7K43_00570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7K43_00580	COG0655	NAD(P)H dehydrogenase (quinone) activity
C7K43_00585	COG0228	four-way junction DNA binding
C7K43_00590	COG1837	Belongs to the UPF0109 family
C7K43_00610	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C7K43_00615	COG3052	prosthetic group binding
C7K43_00635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K43_00645	COG2514	catechol 2,3-dioxygenase activity
C7K43_00660	COG0336	Belongs to the RNA methyltransferase TrmD family
C7K43_00665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7K43_00675	COG3830	Belongs to the UPF0237 family
C7K43_00680	COG2848	UPF0210 protein
C7K43_00685	COG1956	GAF domain-containing protein
C7K43_00700	COG0745	RESPONSE REGULATOR receiver
C7K43_00705	COG3850	Histidine kinase
C7K43_00705	COG5002	protein histidine kinase activity
C7K43_00740	COG1368	sulfuric ester hydrolase activity
C7K43_00745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7K43_00755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7K43_00760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C7K43_00765	COG0166	Belongs to the GPI family
C7K43_00770	COG0398	Pfam SNARE associated Golgi protein
C7K43_00800	COG0561	phosphatase activity
C7K43_00805	COG2252	PERMEase
C7K43_00815	COG0587	DNA-directed DNA polymerase activity
C7K43_00820	COG0205	6-phosphofructokinase activity
C7K43_00835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7K43_00840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C7K43_00845	COG0745	RESPONSE REGULATOR receiver
C7K43_00850	COG5002	protein histidine kinase activity
C7K43_00940	COG1396	sequence-specific DNA binding
C7K43_00950	COG5632	N-Acetylmuramoyl-L-alanine amidase
C7K43_00950	COG5263	repeat protein
C7K43_00970	COG3048	D-serine ammonia-lyase activity
C7K43_00975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K43_00980	COG1349	DNA-binding transcription factor activity
C7K43_00990	COG3284	Transcriptional regulator
C7K43_00995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K43_01000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C7K43_01005	COG0022	dehydrogenase e1 component
C7K43_01010	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7K43_01030	COG0656	L-ascorbic acid biosynthetic process
C7K43_01045	COG4120	Belongs to the binding-protein-dependent transport system permease family
C7K43_01055	COG3425	synthase
C7K43_01075	COG0741	lytic transglycosylase activity
C7K43_01085	COG0358	DNA primase activity
C7K43_01090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7K43_01110	COG2996	Protein conserved in bacteria
C7K43_01115	COG0735	belongs to the Fur family
C7K43_01125	COG4974	Belongs to the 'phage' integrase family
C7K43_01130	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C7K43_01135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7K43_01140	COG1187	pseudouridine synthase activity
C7K43_01145	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C7K43_01150	COG1141	Ferredoxin
C7K43_01160	COG0514	ATP-dependent DNA helicase (RecQ)
C7K43_01170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7K43_01180	COG0539	negative regulation of cytoplasmic translation
C7K43_01185	COG1160	GTP binding
C7K43_01190	COG0776	regulation of translation
C7K43_01200	COG0457	Tetratricopeptide repeat
C7K43_01205	COG5582	Belongs to the UPF0302 family
C7K43_01215	COG1694	Mazg nucleotide pyrophosphohydrolase
C7K43_01220	COG0617	tRNA 3'-terminal CCA addition
C7K43_01240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K43_01245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7K43_01260	COG1940	carbohydrate kinase activity
C7K43_01265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K43_01275	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7K43_01280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7K43_01285	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C7K43_01295	COG1214	PFAM Peptidase M22, glycoprotease
C7K43_01310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7K43_01315	COG0052	Belongs to the universal ribosomal protein uS2 family
C7K43_01320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7K43_01325	COG0528	UMP kinase activity
C7K43_01330	COG0233	cytoplasmic translational termination
C7K43_01335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7K43_01340	COG4589	Belongs to the CDS family
C7K43_01345	COG0750	zinc metalloprotease
C7K43_01350	COG0442	prolyl-tRNA aminoacylation
C7K43_01360	COG2137	regulation of response to DNA damage stimulus
C7K43_01370	COG3557	Belongs to the UPF0374 family
C7K43_01380	COG1253	flavin adenine dinucleotide binding
C7K43_01385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C7K43_01400	COG0542	response to heat
C7K43_01410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_01415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7K43_01430	COG0438	transferase activity, transferring glycosyl groups
C7K43_01435	COG2084	Dehydrogenase
C7K43_01440	COG4703	Protein of unknown function (DUF1797)
C7K43_01445	COG1428	Deoxynucleoside kinase
C7K43_01455	COG1846	Transcriptional regulator
C7K43_01460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7K43_01465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K43_01470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C7K43_01475	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_01485	COG0511	ligase activity, forming carbon-carbon bonds
C7K43_01490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7K43_01495	COG0439	Biotin carboxylase
C7K43_01500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7K43_01505	COG0825	malonyl-CoA metabolic process
C7K43_01515	COG1607	acyl-coa hydrolase
C7K43_01525	COG1668	transmembrane transport
C7K43_01530	COG0657	acetylesterase activity
C7K43_01530	COG2755	lipolytic protein G-D-S-L family
C7K43_01535	COG0583	DNA-binding transcription factor activity
C7K43_01545	COG1288	antiporter activity
C7K43_01550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K43_01565	COG2190	(PTS) system
C7K43_01565	COG1263	PTS System
C7K43_01565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_01570	COG0698	ribose 5-phosphate isomerase
C7K43_01575	COG1349	DNA-binding transcription factor activity
C7K43_01595	COG3394	polysaccharide catabolic process
C7K43_01605	COG2084	Dehydrogenase
C7K43_01610	COG3775	system Galactitol-specific IIC component
C7K43_01615	COG1609	Transcriptional regulator
C7K43_01620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K43_01625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K43_01650	COG1373	ATPase (AAA superfamily
C7K43_01655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K43_01660	COG0765	amino acid transport
C7K43_01675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_01675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_01680	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_01685	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C7K43_01690	COG1737	Transcriptional regulator
C7K43_01700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_01700	COG1263	PTS System
C7K43_01730	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C7K43_01755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_01755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_01755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_01760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_01765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_01765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_01765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_01775	COG1011	Hydrolase
C7K43_01795	COG3959	Transketolase, thiamine diphosphate binding domain
C7K43_01800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C7K43_01810	COG3414	Phosphotransferase system galactitol-specific IIB component
C7K43_01815	COG3775	system Galactitol-specific IIC component
C7K43_01825	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_01825	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_01835	COG4975	Glucose uptake
C7K43_01840	COG0673	inositol 2-dehydrogenase activity
C7K43_01845	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K43_01850	COG1063	alcohol dehydrogenase
C7K43_01860	COG1105	Belongs to the carbohydrate kinase PfkB family
C7K43_01875	COG3684	Belongs to the aldolase LacD family
C7K43_01900	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_01900	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_01905	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_01915	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_01935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_01945	COG2190	(PTS) system
C7K43_01945	COG1263	PTS System
C7K43_01945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_01950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_01950	COG1263	PTS System
C7K43_01965	COG1129	ABC transporter
C7K43_01985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_01990	COG0277	FAD linked oxidase domain protein
C7K43_02010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C7K43_02025	COG1175	transmembrane transport
C7K43_02030	COG0395	ABC-type sugar transport system, permease component
C7K43_02035	COG1621	beta-fructofuranosidase activity
C7K43_02055	COG3711	transcriptional antiterminator
C7K43_02070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K43_02075	COG2188	Transcriptional regulator
C7K43_02080	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_02090	COG0383	alpha-mannosidase activity
C7K43_02110	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7K43_02120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_02130	COG1621	beta-fructofuranosidase activity
C7K43_02135	COG1609	Transcriptional regulator
C7K43_02140	COG0366	Alpha amylase catalytic
C7K43_02145	COG1263	PTS System
C7K43_02145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_02160	COG3715	PTS system
C7K43_02165	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_02175	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_02175	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_02195	COG1082	Xylose isomerase domain protein TIM barrel
C7K43_02210	COG2190	(PTS) system
C7K43_02210	COG1263	PTS System
C7K43_02210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_02215	COG1953	Uracil, thiamine, allantoin
C7K43_02220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7K43_02225	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7K43_02240	COG1269	ATP hydrolysis coupled proton transport
C7K43_02245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K43_02255	COG1527	subunit (C
C7K43_02260	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
C7K43_02265	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C7K43_02270	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C7K43_02275	COG1394	ATPase activity, coupled to movement of substances
C7K43_02290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C7K43_02295	COG0471	metal ion transport
C7K43_02325	COG0511	ligase activity, forming carbon-carbon bonds
C7K43_02330	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C7K43_02355	COG2723	6-phospho-beta-galactosidase activity
C7K43_02360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_02380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7K43_02385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K43_02395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_02395	COG1263	PTS System
C7K43_02400	COG1486	melibiose metabolic process
C7K43_02405	COG1737	Transcriptional regulator
C7K43_02440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K43_02445	COG0165	Argininosuccinate lyase
C7K43_02460	COG2096	Adenosyltransferase
C7K43_02485	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7K43_02505	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7K43_02510	COG1534	Rna-binding protein
C7K43_02515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7K43_02520	COG1713	HD superfamily hydrolase involved in NAD metabolism
C7K43_02525	COG0799	negative regulation of ribosome biogenesis
C7K43_02530	COG2226	methyltransferase
C7K43_02535	COG1323	Belongs to the UPF0348 family
C7K43_02540	COG0217	transcriptional regulatory protein
C7K43_02545	COG0431	NADPH-dependent FMN reductase
C7K43_02545	COG3976	FMN-binding domain protein
C7K43_02545	COG1053	succinate dehydrogenase
C7K43_02550	COG0431	NADPH-dependent FMN reductase
C7K43_02550	COG1053	succinate dehydrogenase
C7K43_02550	COG3976	FMN-binding domain protein
C7K43_02565	COG3973	AAA domain
C7K43_02590	COG1051	belongs to the nudix hydrolase family
C7K43_02595	COG3189	MarR family transcriptional regulator
C7K43_02615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7K43_02620	COG0779	Required for maturation of 30S ribosomal subunits
C7K43_02625	COG0195	Participates in both transcription termination and antitermination
C7K43_02630	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C7K43_02645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7K43_02655	COG0196	riboflavin kinase activity
C7K43_02675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7K43_02685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7K43_02710	COG1126	abc transporter atp-binding protein
C7K43_02715	COG0765	amino acid transport
C7K43_02720	COG0556	nucleotide-excision repair
C7K43_02725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7K43_02730	COG1660	Displays ATPase and GTPase activities
C7K43_02735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C7K43_02740	COG1481	regulation of sporulation
C7K43_02750	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C7K43_02760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7K43_02780	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C7K43_02785	COG1074	ATP-dependent DNA helicase activity
C7K43_02790	COG1733	regulation of RNA biosynthetic process
C7K43_02795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7K43_02800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K43_02800	COG0072	phenylalanine-tRNA ligase activity
C7K43_02805	COG0180	Tryptophanyl-tRNA synthetase
C7K43_02810	COG1126	abc transporter atp-binding protein
C7K43_02815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K43_02820	COG0765	amino acid transport
C7K43_02825	COG0765	amino acid transport
C7K43_02835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C7K43_02850	COG0517	IMP dehydrogenase activity
C7K43_02855	COG0668	transmembrane transport
C7K43_02860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7K43_02865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7K43_02870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7K43_02885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7K43_02895	COG1234	tRNA 3'-trailer cleavage
C7K43_02900	COG0300	oxidoreductase activity
C7K43_02910	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C7K43_02910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7K43_02915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K43_02920	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7K43_02930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7K43_02940	COG4224	UPF0291 protein
C7K43_02950	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K43_02950	COG1388	LysM domain
C7K43_02955	COG0735	belongs to the Fur family
C7K43_02960	COG3935	DnaD domain protein
C7K43_02965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K43_02970	COG3331	DNA recombination
C7K43_02975	COG4474	Belongs to the UPF0398 family
C7K43_02980	COG3599	regulation of cell shape
C7K43_02990	COG0116	Belongs to the methyltransferase superfamily
C7K43_02995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C7K43_03005	COG1283	sodium-dependent phosphate transmembrane transporter activity
C7K43_03020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K43_03030	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_03040	COG2832	Protein of unknown function (DUF454)
C7K43_03050	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_03065	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C7K43_03070	COG1418	mRNA catabolic process
C7K43_03080	COG0513	Belongs to the DEAD box helicase family
C7K43_03095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7K43_03105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7K43_03110	COG0328	RNA-DNA hybrid ribonuclease activity
C7K43_03120	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C7K43_03130	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C7K43_03135	COG0564	pseudouridine synthase activity
C7K43_03140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C7K43_03145	COG2233	PERMEase
C7K43_03150	COG0540	Belongs to the ATCase OTCase family
C7K43_03155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7K43_03160	COG0505	Belongs to the CarA family
C7K43_03165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7K43_03170	COG0284	orotidine-5'-phosphate decarboxylase activity
C7K43_03175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7K43_03200	COG4120	Belongs to the binding-protein-dependent transport system permease family
C7K43_03210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7K43_03215	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C7K43_03225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7K43_03230	COG0287	Prephenate dehydrogenase
C7K43_03240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7K43_03245	COG0077	Prephenate dehydratase
C7K43_03250	COG1316	TRANSCRIPTIONal
C7K43_03255	COG1307	EDD domain protein, DegV family
C7K43_03260	COG2124	cytochrome p450
C7K43_03275	COG0546	phosphoglycolate phosphatase activity
C7K43_03280	COG1349	DNA-binding transcription factor activity
C7K43_03285	COG4974	Belongs to the 'phage' integrase family
C7K43_03320	COG3041	Addiction module toxin RelE StbE family
C7K43_03325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7K43_03330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7K43_03365	COG0456	acetyltransferase
C7K43_03370	COG0561	phosphatase activity
C7K43_03390	COG1388	LysM domain
C7K43_03405	COG0702	epimerase
C7K43_03420	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K43_03455	COG2151	metal-sulfur cluster biosynthetic enzyme
C7K43_03465	COG1199	ATP-dependent helicase activity
C7K43_03465	COG1199	ATP-dependent helicase activity
C7K43_03480	COG1968	undecaprenyl-diphosphatase activity
C7K43_03485	COG1392	Phosphate transport regulator
C7K43_03490	COG0306	phosphate transporter
C7K43_03495	COG0268	Binds directly to 16S ribosomal RNA
C7K43_03500	COG1466	dna polymerase III delta subunit
C7K43_03505	COG2333	competence protein COMEC
C7K43_03505	COG0658	competence protein
C7K43_03510	COG2131	deaminase
C7K43_03515	COG1555	photosystem II stabilization
C7K43_03515	COG1596	polysaccharide export
C7K43_03520	COG0546	phosphoglycolate phosphatase activity
C7K43_03525	COG0436	Aminotransferase
C7K43_03530	COG1126	abc transporter atp-binding protein
C7K43_03535	COG0765	amino acid transport
C7K43_03540	COG0371	Dehydrogenase
C7K43_03545	COG0519	Catalyzes the synthesis of GMP from XMP
C7K43_03555	COG0702	epimerase
C7K43_03580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7K43_03590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7K43_03595	COG0154	amidase activity
C7K43_03600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7K43_03615	COG0038	chloride channel
C7K43_03620	COG1349	DNA-binding transcription factor activity
C7K43_03625	COG1105	Belongs to the carbohydrate kinase PfkB family
C7K43_03630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_03630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_03630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_03635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7K43_03640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7K43_03645	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7K43_03655	COG1714	RDD family
C7K43_03665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7K43_03670	COG1902	pentaerythritol trinitrate reductase activity
C7K43_03680	COG2365	Tyrosine phosphatase family
C7K43_03695	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C7K43_03715	COG0481	GTPase activity
C7K43_03725	COG1396	sequence-specific DNA binding
C7K43_03730	COG2801	Transposase and inactivated derivatives
C7K43_03740	COG0628	permease
C7K43_03745	COG0542	response to heat
C7K43_03755	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7K43_03760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C7K43_03765	COG2384	SAM-dependent methyltransferase
C7K43_03770	COG1484	DNA-dependent DNA replication
C7K43_03780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7K43_03785	COG0237	dephospho-CoA kinase activity
C7K43_03790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7K43_03795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K43_03795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K43_03810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7K43_03815	COG3091	SprT-like family
C7K43_03820	COG2183	response to ionizing radiation
C7K43_03845	COG3480	Lon protease (S16) C-terminal proteolytic domain
C7K43_03850	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7K43_03855	COG0742	ribosomal rna small subunit methyltransferase
C7K43_03860	COG4471	UPF0298 protein
C7K43_03875	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C7K43_03880	COG0772	Belongs to the SEDS family
C7K43_03885	COG4838	Belongs to the UPF0358 family
C7K43_03895	COG0483	inositol monophosphate 1-phosphatase activity
C7K43_03900	COG4476	Belongs to the UPF0223 family
C7K43_03925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7K43_03930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C7K43_03935	COG0516	GMP reductase activity
C7K43_03940	COG4989	oxidoreductase activity
C7K43_03945	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7K43_03950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7K43_03955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K43_03960	COG1966	Carbon starvation protein
C7K43_03965	COG3279	Response regulator of the LytR AlgR family
C7K43_03970	COG3275	phosphorelay sensor kinase activity
C7K43_03980	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K43_03985	COG1876	peptidase activity
C7K43_04025	COG0436	Aminotransferase
C7K43_04040	COG0667	Aldo Keto reductase
C7K43_04045	COG0366	Alpha amylase catalytic
C7K43_04045	COG3103	Sh3 type 3 domain protein
C7K43_04050	COG0058	SHG alpha-glucan phosphorylase activity
C7K43_04060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K43_04065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K43_04075	COG1227	inorganic diphosphatase activity
C7K43_04080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K43_04085	COG1882	Formate acetyltransferase
C7K43_04090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7K43_04095	COG0187	DNA topoisomerase II activity
C7K43_04100	COG1832	CoA-binding protein
C7K43_04105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C7K43_04120	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C7K43_04125	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C7K43_04135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7K43_04140	COG0758	DNA mediated transformation
C7K43_04145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7K43_04150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7K43_04160	COG0681	Belongs to the peptidase S26 family
C7K43_04165	COG0793	Belongs to the peptidase S41A family
C7K43_04170	COG4479	Belongs to the UPF0346 family
C7K43_04180	COG4698	Protein conserved in bacteria
C7K43_04185	COG2755	lipolytic protein G-D-S-L family
C7K43_04190	COG1307	EDD domain protein, DegV family
C7K43_04195	COG0371	Dehydrogenase
C7K43_04200	COG1272	protein, Hemolysin III
C7K43_04210	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7K43_04215	COG0488	(ABC) transporter
C7K43_04220	COG0768	penicillin binding
C7K43_04225	COG1316	TRANSCRIPTIONal
C7K43_04230	COG1682	transport, permease protein
C7K43_04235	COG1134	teichoic acid transport
C7K43_04240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C7K43_04250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C7K43_04255	COG2246	polysaccharide biosynthetic process
C7K43_04260	COG2246	polysaccharide biosynthetic process
C7K43_04270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7K43_04275	COG0463	Glycosyl transferase, family 2
C7K43_04280	COG1368	sulfuric ester hydrolase activity
C7K43_04295	COG4841	protein insertion into membrane
C7K43_04300	COG0569	domain protein
C7K43_04305	COG2197	response regulator
C7K43_04310	COG4585	Histidine kinase
C7K43_04320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7K43_04325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7K43_04355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K43_04355	COG0463	Glycosyl transferase, family 2
C7K43_04360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K43_04360	COG0463	Glycosyl transferase, family 2
C7K43_04365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K43_04375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K43_04385	COG0463	Glycosyl transferase, family 2
C7K43_04385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K43_04400	COG0017	Asparaginyl-tRNA synthetase
C7K43_04405	COG0436	Aminotransferase
C7K43_04420	COG1278	Cold shock
C7K43_04435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7K43_04445	COG0577	efflux transmembrane transporter activity
C7K43_04460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7K43_04480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K43_04500	COG3588	fructose-bisphosphate aldolase
C7K43_04515	COG0523	cobalamin synthesis protein
C7K43_04540	COG0596	Alpha beta hydrolase
C7K43_04545	COG0604	alcohol dehydrogenase
C7K43_04550	COG0745	RESPONSE REGULATOR receiver
C7K43_04555	COG5002	protein histidine kinase activity
C7K43_04560	COG1136	(ABC) transporter
C7K43_04565	COG0577	efflux transmembrane transporter activity
C7K43_04590	COG0745	RESPONSE REGULATOR receiver
C7K43_04600	COG2205	protein histidine kinase activity
C7K43_04605	COG1131	(ABC) transporter
C7K43_04655	COG0739	heme binding
C7K43_04690	COG1396	sequence-specific DNA binding
C7K43_04695	COG2176	DNA-directed DNA polymerase activity
C7K43_04725	COG3177	Filamentation induced by cAMP protein fic
C7K43_04730	COG0584	glycerophosphoryl diester phosphodiesterase
C7K43_04760	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7K43_04765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_04770	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_04770	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_04780	COG0673	inositol 2-dehydrogenase activity
C7K43_04790	COG1686	Belongs to the peptidase S11 family
C7K43_04815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7K43_04820	COG1254	Belongs to the acylphosphatase family
C7K43_04835	COG0751	glycine-tRNA ligase activity
C7K43_04840	COG0752	glycyl-tRNA synthetase alpha subunit
C7K43_04845	COG1381	Involved in DNA repair and RecF pathway recombination
C7K43_04850	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7K43_04855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C7K43_04860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7K43_04870	COG1702	phosphate starvation-inducible protein PhoH
C7K43_04875	COG1610	YqeY-like protein
C7K43_04880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C7K43_04890	COG1253	flavin adenine dinucleotide binding
C7K43_04900	COG0735	belongs to the Fur family
C7K43_04905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7K43_04910	COG0083	homoserine kinase activity
C7K43_04915	COG0460	homoserine dehydrogenase
C7K43_04920	COG0640	Transcriptional regulator
C7K43_04925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7K43_04930	COG2723	6-phospho-beta-galactosidase activity
C7K43_04950	COG3763	UPF0154 protein
C7K43_04955	COG0656	L-ascorbic acid biosynthetic process
C7K43_04960	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C7K43_04970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7K43_04985	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_04995	COG3775	system Galactitol-specific IIC component
C7K43_05010	COG1609	Transcriptional regulator
C7K43_05040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7K43_05045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7K43_05050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7K43_05055	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C7K43_05070	COG1983	PspC domain protein
C7K43_05080	COG0704	Plays a role in the regulation of phosphate uptake
C7K43_05085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7K43_05090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7K43_05095	COG0581	inorganic phosphate transmembrane transporter activity
C7K43_05100	COG0573	inorganic phosphate transmembrane transporter activity
C7K43_05105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7K43_05115	COG2177	Part of the ABC transporter FtsEX involved in
C7K43_05120	COG2884	Cell division ATP-binding protein ftsE
C7K43_05130	COG0653	protein targeting
C7K43_05145	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C7K43_05150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_05160	COG1739	Uncharacterized protein family UPF0029
C7K43_05185	COG0517	IMP dehydrogenase activity
C7K43_05190	COG0410	ABC transporter
C7K43_05195	COG0411	ABC transporter
C7K43_05205	COG0559	Belongs to the binding-protein-dependent transport system permease family
C7K43_05230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7K43_05240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7K43_05245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7K43_05250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7K43_05255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7K43_05260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K43_05265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7K43_05270	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K43_05275	COG0356	it plays a direct role in the translocation of protons across the membrane
C7K43_05280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7K43_05285	COG0557	exoribonuclease II activity
C7K43_05295	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7K43_05305	COG0148	phosphopyruvate hydratase activity
C7K43_05310	COG0149	triose-phosphate isomerase activity
C7K43_05315	COG0126	phosphoglycerate kinase activity
C7K43_05350	COG0095	Lipoate-protein ligase
C7K43_05355	COG1078	dGTPase activity
C7K43_05365	COG0346	lactoylglutathione lyase activity
C7K43_05375	COG3118	belongs to the thioredoxin family
C7K43_05380	COG1193	negative regulation of DNA recombination
C7K43_05395	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7K43_05405	COG2059	Chromate
C7K43_05425	COG4175	Glycine betaine
C7K43_05425	COG3448	diguanylate cyclase activity
C7K43_05430	COG2188	Transcriptional regulator
C7K43_05440	COG5646	InterPro IPR014922
C7K43_05445	COG1464	Belongs to the NlpA lipoprotein family
C7K43_05460	COG3906	Belongs to the UPF0473 family
C7K43_05465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7K43_05470	COG4472	Bacterial protein of unknown function (DUF965)
C7K43_05475	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C7K43_05480	COG0488	(ABC) transporter
C7K43_05485	COG0686	Belongs to the AlaDH PNT family
C7K43_05500	COG0346	lactoylglutathione lyase activity
C7K43_05510	COG1177	transmembrane transport
C7K43_05515	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7K43_05520	COG3842	ATPase activity
C7K43_05525	COG0604	alcohol dehydrogenase
C7K43_05535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7K43_05540	COG4684	Psort location CytoplasmicMembrane, score
C7K43_05545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7K43_05555	COG2176	DNA-directed DNA polymerase activity
C7K43_05560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K43_05565	COG0802	atpase or kinase
C7K43_05570	COG0280	phosphate acetyltransferase
C7K43_05575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7K43_05580	COG0561	phosphatase activity
C7K43_05600	COG0583	DNA-binding transcription factor activity
C7K43_05605	COG1368	sulfuric ester hydrolase activity
C7K43_05615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C7K43_05640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C7K43_05655	COG5002	protein histidine kinase activity
C7K43_05660	COG0745	RESPONSE REGULATOR receiver
C7K43_05680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7K43_05690	COG2217	Heavy metal translocating P-type atpase
C7K43_05705	COG0789	Transcriptional regulator
C7K43_05710	COG0656	L-ascorbic acid biosynthetic process
C7K43_05770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7K43_05785	COG0745	RESPONSE REGULATOR receiver
C7K43_05800	COG2205	protein histidine kinase activity
C7K43_05830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7K43_05835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7K43_05865	COG0367	asparagine synthase
C7K43_05875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K43_05880	COG1811	Na channel or pump
C7K43_05925	COG0789	Transcriptional regulator
C7K43_05930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7K43_05935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7K43_05940	COG2130	NADP-dependent
C7K43_05970	COG1136	(ABC) transporter
C7K43_05995	COG5002	protein histidine kinase activity
C7K43_06000	COG0745	RESPONSE REGULATOR receiver
C7K43_06050	COG1131	(ABC) transporter
C7K43_06055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K43_06060	COG0626	cystathionine gamma-synthase activity
C7K43_06070	COG1473	amidohydrolase
C7K43_06085	COG3344	reverse transcriptase
C7K43_06100	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C7K43_06115	COG0604	alcohol dehydrogenase
C7K43_06125	COG0640	Transcriptional regulator
C7K43_06130	COG0561	phosphatase activity
C7K43_06165	COG2261	transglycosylase associated protein
C7K43_06215	COG2022	thiamine diphosphate biosynthetic process
C7K43_06220	COG2390	Transcriptional regulator
C7K43_06250	COG0254	rRNA binding
C7K43_06260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C7K43_06265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7K43_06275	COG0504	CTP synthase activity
C7K43_06280	COG0174	glutamine synthetase
C7K43_06285	COG0789	Transcriptional regulator
C7K43_06295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7K43_06300	COG0584	glycerophosphoryl diester phosphodiesterase
C7K43_06310	COG0740	serine-type endopeptidase activity
C7K43_06315	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C7K43_06320	COG1132	(ABC) transporter
C7K43_06345	COG1278	Cold shock
C7K43_06350	COG2003	Belongs to the UPF0758 family
C7K43_06355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K43_06360	COG0285	dihydrofolate synthase activity
C7K43_06365	COG0525	valine-tRNA ligase activity
C7K43_06370	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C7K43_06375	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C7K43_06380	COG0301	tRNA thio-modification
C7K43_06385	COG1104	cysteine desulfurase activity
C7K43_06390	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C7K43_06395	COG0527	aspartate kinase activity
C7K43_06400	COG4166	transmembrane transport
C7K43_06410	COG4876	unkown
C7K43_06420	COG0561	phosphatase activity
C7K43_06425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C7K43_06430	COG0500	methyltransferase
C7K43_06435	COG3142	Participates in the control of copper homeostasis
C7K43_06440	COG2239	Acts as a magnesium transporter
C7K43_06445	COG0564	pseudouridine synthase activity
C7K43_06450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7K43_06455	COG2357	RelA SpoT domain protein
C7K43_06460	COG4116	CYTH
C7K43_06465	COG1164	Oligoendopeptidase f
C7K43_06480	COG4862	establishment of competence for transformation
C7K43_06485	COG1393	Belongs to the ArsC family
C7K43_06490	COG1132	(ABC) transporter
C7K43_06495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7K43_06500	COG0419	ATPase involved in DNA repair
C7K43_06505	COG0420	3'-5' exonuclease activity
C7K43_06510	COG0204	Acyl-transferase
C7K43_06515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C7K43_06520	COG2827	Endonuclease containing a URI domain
C7K43_06525	COG0038	chloride channel
C7K43_06535	COG1131	(ABC) transporter
C7K43_06545	COG4658	electron transport chain
C7K43_06550	COG4656	Part of a membrane complex involved in electron transport
C7K43_06555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7K43_06575	COG4470	Protein conserved in bacteria
C7K43_06580	COG0737	Belongs to the 5'-nucleotidase family
C7K43_06595	COG0590	tRNA wobble adenosine to inosine editing
C7K43_06605	COG2738	Putative neutral zinc metallopeptidase
C7K43_06610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C7K43_06615	COG0019	diaminopimelate decarboxylase activity
C7K43_06620	COG1473	amidohydrolase
C7K43_06630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7K43_06635	COG2171	N-acyltransferase activity
C7K43_06660	COG0028	Belongs to the TPP enzyme family
C7K43_06670	COG0716	FMN binding
C7K43_06680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C7K43_06685	COG0561	phosphatase activity
C7K43_06695	COG0719	Fe-S assembly protein
C7K43_06700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7K43_06715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K43_06730	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C7K43_06760	COG0025	NhaP-type Na H and K H
C7K43_06765	COG1045	serine acetyltransferase
C7K43_06770	COG0626	cystathionine gamma-synthase activity
C7K43_06775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7K43_06785	COG3527	Alpha-acetolactate decarboxylase
C7K43_06790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7K43_06815	COG2226	methyltransferase
C7K43_06825	COG0517	IMP dehydrogenase activity
C7K43_06825	COG1125	glycine betaine transport
C7K43_06830	COG1174	glycine betaine transport
C7K43_06835	COG1132	(ABC) transporter
C7K43_06845	COG3104	oligopeptide transport
C7K43_06850	COG1428	Deoxynucleoside kinase
C7K43_06860	COG0431	NADPH-dependent FMN reductase
C7K43_06860	COG1053	succinate dehydrogenase
C7K43_06860	COG3976	FMN-binding domain protein
C7K43_06875	COG1070	Carbohydrate kinase
C7K43_06880	COG2610	gluconate transmembrane transporter activity
C7K43_06895	COG0114	fumarate hydratase activity
C7K43_06910	COG1653	transport
C7K43_06935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7K43_06945	COG1132	(ABC) transporter
C7K43_06950	COG1132	(ABC) transporter
C7K43_06955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C7K43_06965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7K43_06970	COG0719	Fe-S assembly protein
C7K43_06980	COG2153	protein acetylation
C7K43_06990	COG1185	polyribonucleotide nucleotidyltransferase activity
C7K43_06995	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7K43_07005	COG0628	permease
C7K43_07015	COG2706	6-phosphogluconolactonase activity
C7K43_07045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K43_07045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K43_07060	COG2239	Acts as a magnesium transporter
C7K43_07085	COG0675	Transposase, IS605 OrfB family
C7K43_07090	COG4608	Belongs to the ABC transporter superfamily
C7K43_07095	COG0444	Belongs to the ABC transporter superfamily
C7K43_07100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7K43_07105	COG0601	transmembrane transport
C7K43_07115	COG4166	transmembrane transport
C7K43_07120	COG4166	transmembrane transport
C7K43_07125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7K43_07130	COG1674	ftsk spoiiie
C7K43_07130	COG1280	lysine exporter protein (LysE YggA)
C7K43_07135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K43_07140	COG1126	abc transporter atp-binding protein
C7K43_07145	COG0765	amino acid transport
C7K43_07150	COG2508	Transcriptional regulator
C7K43_07155	COG3842	ATPase activity
C7K43_07170	COG0482	sulfurtransferase activity
C7K43_07180	COG1104	cysteine desulfurase activity
C7K43_07185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7K43_07195	COG3590	peptidase
C7K43_07200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7K43_07220	COG3853	Toxic anion resistance protein (TelA)
C7K43_07225	COG0531	amino acid
C7K43_07230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7K43_07235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7K43_07250	COG2801	Transposase and inactivated derivatives
C7K43_07260	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C7K43_07265	COG1490	D-aminoacyl-tRNA deacylase activity
C7K43_07270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7K43_07275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7K43_07280	COG2264	protein methyltransferase activity
C7K43_07290	COG2094	Belongs to the DNA glycosylase MPG family
C7K43_07295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7K43_07325	COG0589	response to stress
C7K43_07335	COG1131	(ABC) transporter
C7K43_07340	COG1309	transcriptional regulator
C7K43_07355	COG0561	phosphatase activity
C7K43_07360	COG0656	L-ascorbic acid biosynthetic process
C7K43_07370	COG0656	L-ascorbic acid biosynthetic process
C7K43_07375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7K43_07385	COG4473	ABC transporter
C7K43_07390	COG1131	(ABC) transporter
C7K43_07395	COG1132	(ABC) transporter
C7K43_07410	COG0242	peptide deformylase activity
C7K43_07420	COG1464	Belongs to the NlpA lipoprotein family
C7K43_07425	COG2011	ABC-type metal ion transport system permease component
C7K43_07430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7K43_07435	COG1827	regulation of RNA biosynthetic process
C7K43_07440	COG0110	maltose O-acetyltransferase activity
C7K43_07450	COG0765	amino acid transport
C7K43_07455	COG1126	abc transporter atp-binding protein
C7K43_07460	COG1114	Component of the transport system for branched-chain amino acids
C7K43_07470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7K43_07475	COG2255	four-way junction helicase activity
C7K43_07480	COG0632	four-way junction helicase activity
C7K43_07485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7K43_07510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C7K43_07515	COG4550	Control of competence regulator ComK, YlbF/YmcA
C7K43_07520	COG1692	metallophosphoesterase
C7K43_07525	COG0561	phosphatase activity
C7K43_07530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7K43_07540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7K43_07545	COG1131	(ABC) transporter
C7K43_07555	COG3279	Response regulator of the LytR AlgR family
C7K43_07565	COG1268	BioY protein
C7K43_07570	COG4493	Belongs to the UPF0637 family
C7K43_07595	COG2918	glutathione biosynthetic process
C7K43_07595	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7K43_07600	COG2723	6-phospho-beta-galactosidase activity
C7K43_07605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_07605	COG2190	(PTS) system
C7K43_07605	COG1263	PTS System
C7K43_07610	COG2188	Transcriptional regulator
C7K43_07615	COG0552	protein localization to endoplasmic reticulum
C7K43_07620	COG0561	phosphatase activity
C7K43_07625	COG1196	nuclear chromosome segregation
C7K43_07630	COG0571	ribonuclease III activity
C7K43_07645	COG0601	transmembrane transport
C7K43_07650	COG4608	Belongs to the ABC transporter superfamily
C7K43_07660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K43_07665	COG0416	fatty acid biosynthetic process
C7K43_07670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7K43_07695	COG1461	Dihydroxyacetone kinase
C7K43_07705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7K43_07715	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C7K43_07755	COG0174	glutamine synthetase
C7K43_07760	COG0101	tRNA pseudouridine synthase activity
C7K43_07770	COG1122	ATPase activity
C7K43_07775	COG1122	ATPase activity
C7K43_07780	COG0203	ribosomal protein L17
C7K43_07785	COG0202	RNA polymerase activity
C7K43_07790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7K43_07795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7K43_07800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7K43_07805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7K43_07810	COG0563	adenylate kinase activity
C7K43_07820	COG0200	Binds to the 23S rRNA
C7K43_07825	COG1841	ribosomal large subunit assembly
C7K43_07830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7K43_07835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7K43_07840	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7K43_07845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7K43_07850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7K43_07855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7K43_07860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7K43_07865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7K43_07870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7K43_07875	COG0255	Belongs to the universal ribosomal protein uL29 family
C7K43_07880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7K43_07885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7K43_07890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7K43_07895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7K43_07900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7K43_07905	COG0089	rRNA binding
C7K43_07910	COG0088	Forms part of the polypeptide exit tunnel
C7K43_07915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7K43_07940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K43_07945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_07955	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7K43_07960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_07960	COG3711	transcriptional antiterminator
C7K43_07965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_07980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7K43_07985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7K43_07990	COG0049	tRNA binding
C7K43_07995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7K43_08000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7K43_08005	COG0588	phosphoglycerate mutase activity
C7K43_08010	COG1979	alcohol dehydrogenase
C7K43_08025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C7K43_08045	COG1744	ABC transporter substrate-binding protein PnrA-like
C7K43_08050	COG0295	cytidine deaminase activity
C7K43_08055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K43_08060	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C7K43_08065	COG1609	Transcriptional regulator
C7K43_08070	COG2813	Specifically methylates the guanine in position
C7K43_08075	COG1072	(Pantothenic acid kinase))
C7K43_08080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7K43_08080	COG0519	Catalyzes the synthesis of GMP from XMP
C7K43_08085	COG0456	acetyltransferase
C7K43_08090	COG0456	acetyltransferase
C7K43_08090	COG1846	Transcriptional regulator
C7K43_08100	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C7K43_08115	COG1114	Component of the transport system for branched-chain amino acids
C7K43_08120	COG1396	sequence-specific DNA binding
C7K43_08140	COG0024	Methionine aminopeptidase
C7K43_08150	COG0708	Exodeoxyribonuclease III
C7K43_08155	COG0628	permease
C7K43_08180	COG1131	(ABC) transporter
C7K43_08205	COG0693	protein deglycase activity
C7K43_08210	COG0625	glutathione transferase activity
C7K43_08225	COG1694	Mazg nucleotide pyrophosphohydrolase
C7K43_08230	COG0789	Transcriptional regulator
C7K43_08245	COG2378	regulation of single-species biofilm formation
C7K43_08255	COG1464	Belongs to the NlpA lipoprotein family
C7K43_08260	COG1286	toxin biosynthetic process
C7K43_08280	COG1388	LysM domain
C7K43_08295	COG1131	(ABC) transporter
C7K43_08315	COG0471	metal ion transport
C7K43_08320	COG2197	response regulator
C7K43_08325	COG4585	Histidine kinase
C7K43_08335	COG0259	pyridoxamine-phosphate oxidase activity
C7K43_08345	COG1388	LysM domain
C7K43_08360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_08360	COG2190	(PTS) system
C7K43_08360	COG1263	PTS System
C7K43_08375	COG2340	Cysteine-rich secretory protein family
C7K43_08385	COG1305	Transglutaminase-like
C7K43_08395	COG0714	Associated with various cellular activities
C7K43_08405	COG0435	Glutathione S-transferase
C7K43_08410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7K43_08415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7K43_08420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C7K43_08435	COG1263	PTS System
C7K43_08435	COG2190	(PTS) system
C7K43_08435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_08440	COG3711	transcriptional antiterminator
C7K43_08460	COG1309	transcriptional regulator
C7K43_08485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7K43_08485	COG0574	Belongs to the PEP-utilizing enzyme family
C7K43_08490	COG0517	IMP dehydrogenase activity
C7K43_08495	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7K43_08500	COG0039	L-malate dehydrogenase activity
C7K43_08505	COG0726	polysaccharide deacetylase
C7K43_08505	COG1649	PFAM Uncharacterised BCR, COG1649
C7K43_08510	COG1737	Transcriptional regulator
C7K43_08515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7K43_08525	COG1263	PTS System
C7K43_08525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_08530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C7K43_08545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7K43_08695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7K43_08700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C7K43_08715	COG0037	tRNA processing
C7K43_08720	COG1098	S1 RNA binding domain
C7K43_08730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C7K43_08735	COG2244	polysaccharide biosynthetic process
C7K43_08740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7K43_08745	COG0193	aminoacyl-tRNA hydrolase activity
C7K43_08750	COG0039	L-malate dehydrogenase activity
C7K43_08760	COG0217	transcriptional regulatory protein
C7K43_08775	COG2814	Major facilitator Superfamily
C7K43_08780	COG1012	belongs to the aldehyde dehydrogenase family
C7K43_08790	COG2814	Major facilitator Superfamily
C7K43_08800	COG1252	NADH dehydrogenase
C7K43_08820	COG4166	transmembrane transport
C7K43_08830	COG3443	Belongs to the bacterial solute-binding protein 9 family
C7K43_08830	COG0803	Belongs to the bacterial solute-binding protein 9 family
C7K43_08840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C7K43_08845	COG4988	ABC transporter
C7K43_08850	COG1294	oxidase, subunit
C7K43_08855	COG1271	oxidase subunit
C7K43_08870	COG4975	Glucose uptake
C7K43_08875	COG0018	arginyl-trna synthetase
C7K43_08885	COG1846	Transcriptional regulator
C7K43_08905	COG2153	protein acetylation
C7K43_08935	COG1288	antiporter activity
C7K43_08945	COG0549	Belongs to the carbamate kinase family
C7K43_08955	COG1438	arginine binding
C7K43_08970	COG1438	arginine binding
C7K43_08975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_08975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_08980	COG2723	6-phospho-beta-galactosidase activity
C7K43_08985	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7K43_08990	COG3684	Belongs to the aldolase LacD family
C7K43_09000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K43_09030	COG1349	DNA-binding transcription factor activity
C7K43_09060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7K43_09065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7K43_09075	COG1940	carbohydrate kinase activity
C7K43_09085	COG1744	ABC transporter substrate-binding protein PnrA-like
C7K43_09110	COG1394	ATPase activity, coupled to movement of substances
C7K43_09115	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C7K43_09120	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C7K43_09130	COG1527	subunit (C
C7K43_09140	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K43_09145	COG1269	ATP hydrolysis coupled proton transport
C7K43_09160	COG1285	pathogenesis
C7K43_09165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K43_09175	COG2217	Heavy metal translocating P-type atpase
C7K43_09185	COG0702	epimerase
C7K43_09200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7K43_09205	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_09210	COG3715	PTS system
C7K43_09225	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_09225	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_09235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_09235	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_09285	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_09290	COG3715	PTS system
C7K43_09295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_09305	COG3684	Belongs to the aldolase LacD family
C7K43_09310	COG2222	sugar isomerase
C7K43_09320	COG1461	Dihydroxyacetone kinase
C7K43_09325	COG2376	Dihydroxyacetone kinase
C7K43_09330	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C7K43_09335	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K43_09340	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C7K43_09350	COG3118	belongs to the thioredoxin family
C7K43_09355	COG0386	Belongs to the glutathione peroxidase family
C7K43_09360	COG1846	Transcriptional regulator
C7K43_09365	COG0492	ferredoxin-NADP+ reductase activity
C7K43_09375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7K43_09390	COG0322	excinuclease ABC activity
C7K43_09410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7K43_09420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7K43_09425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7K43_09430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K43_09435	COG0589	response to stress
C7K43_09440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7K43_09445	COG1363	Peptidase, m42
C7K43_09465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7K43_09475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7K43_09480	COG0827	DNA restriction-modification system
C7K43_09505	COG4537	Required for transformation and DNA binding
C7K43_09510	COG1459	type II secretion system
C7K43_09515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K43_09520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7K43_09520	COG2755	lipolytic protein G-D-S-L family
C7K43_09525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7K43_09530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7K43_09535	COG0124	histidyl-tRNA synthetase
C7K43_09540	COG0824	Thioesterase
C7K43_09560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7K43_09565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7K43_09570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7K43_09575	COG4166	transmembrane transport
C7K43_09580	COG2508	Transcriptional regulator
C7K43_09585	COG0402	S-adenosylhomocysteine deaminase activity
C7K43_09590	COG0402	S-adenosylhomocysteine deaminase activity
C7K43_09595	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K43_09600	COG1428	Deoxynucleoside kinase
C7K43_09605	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7K43_09620	COG1304	FMN binding
C7K43_09630	COG0343	queuine tRNA-ribosyltransferase activity
C7K43_09645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C7K43_09670	COG0531	amino acid
C7K43_09675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7K43_09685	COG2337	Toxic component of a toxin-antitoxin (TA) module
C7K43_09695	COG0736	holo-[acyl-carrier-protein] synthase activity
C7K43_09705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7K43_09710	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7K43_09715	COG1671	Belongs to the UPF0178 family
C7K43_09745	COG0572	uridine kinase
C7K43_09750	COG1011	Hydrolase
C7K43_09755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C7K43_09760	COG0509	glycine decarboxylation via glycine cleavage system
C7K43_09765	COG1393	Belongs to the ArsC family
C7K43_09770	COG0772	Belongs to the SEDS family
C7K43_09790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C7K43_09795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7K43_09800	COG0009	L-threonylcarbamoyladenylate synthase
C7K43_09805	COG2890	protein-(glutamine-N5) methyltransferase activity
C7K43_09810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7K43_09815	COG1435	thymidine kinase activity
C7K43_09835	COG0071	Belongs to the small heat shock protein (HSP20) family
C7K43_09840	COG0514	ATP-dependent DNA helicase (RecQ)
C7K43_09850	COG0681	Belongs to the peptidase S26 family
C7K43_09855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K43_09860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7K43_09865	COG3442	glutamine amidotransferase
C7K43_09880	COG1482	cell wall glycoprotein biosynthetic process
C7K43_09895	COG0537	adenosine 5'-monophosphoramidase activity
C7K43_09905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7K43_09910	COG3481	metal-dependent phosphohydrolase, HD sub domain
C7K43_09935	COG3679	Belongs to the UPF0342 family
C7K43_09940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K43_09945	COG0564	pseudouridine synthase activity
C7K43_09950	COG1187	pseudouridine synthase activity
C7K43_09955	COG2244	polysaccharide biosynthetic process
C7K43_09960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7K43_09970	COG1764	response to oxidative stress
C7K43_09975	COG1929	Belongs to the glycerate kinase type-1 family
C7K43_09980	COG0495	leucyl-tRNA aminoacylation
C7K43_09985	COG1388	LysM domain
C7K43_09985	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K43_09990	COG0671	phosphoesterase, PA-phosphatase related
C7K43_09995	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C7K43_10015	COG3775	system Galactitol-specific IIC component
C7K43_10020	COG3414	Phosphotransferase system galactitol-specific IIB component
C7K43_10025	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C7K43_10030	COG0693	protein deglycase activity
C7K43_10040	COG0488	(ABC) transporter
C7K43_10045	COG1464	Belongs to the NlpA lipoprotein family
C7K43_10050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7K43_10065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_10070	COG1609	Transcriptional regulator
C7K43_10085	COG2723	6-phospho-beta-galactosidase activity
C7K43_10090	COG1940	carbohydrate kinase activity
C7K43_10095	COG2205	protein histidine kinase activity
C7K43_10110	COG0745	RESPONSE REGULATOR receiver
C7K43_10115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7K43_10125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C7K43_10125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C7K43_10140	COG4939	FMN-binding domain protein
C7K43_10155	COG0142	geranyltranstransferase activity
C7K43_10160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K43_10165	COG0456	acetyltransferase
C7K43_10180	COG1011	Hydrolase
C7K43_10185	COG0542	response to heat
C7K43_10190	COG4463	regulation of RNA biosynthetic process
C7K43_10195	COG0515	serine threonine protein kinase
C7K43_10195	COG2815	serine threonine protein kinase
C7K43_10205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K43_10205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7K43_10210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7K43_10215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7K43_10220	COG1758	RNA polymerase activity
C7K43_10225	COG0194	GDP metabolic process
C7K43_10230	COG4443	Transcriptional Coactivator p15 (PC4)
C7K43_10245	COG0351	phosphomethylpyrimidine kinase
C7K43_10275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7K43_10280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C7K43_10285	COG0105	UTP biosynthetic process
C7K43_10290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K43_10295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7K43_10300	COG1121	(ABC) transporter
C7K43_10305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7K43_10310	COG1263	PTS System
C7K43_10310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_10315	COG1554	hydrolase, family 65, central catalytic
C7K43_10320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K43_10325	COG2188	Transcriptional regulator
C7K43_10330	COG1418	mRNA catabolic process
C7K43_10340	COG1058	Belongs to the CinA family
C7K43_10340	COG1546	Belongs to the CinA family
C7K43_10345	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7K43_10350	COG1426	Protein conserved in bacteria
C7K43_10355	COG0612	Peptidase, M16
C7K43_10360	COG0612	Peptidase, M16
C7K43_10365	COG1970	mechanosensitive ion channel activity
C7K43_10370	COG4466	Protein conserved in bacteria
C7K43_10380	COG3688	RNA-binding protein containing a PIN domain
C7K43_10385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7K43_10390	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C7K43_10395	COG0215	cysteine-tRNA ligase activity
C7K43_10400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K43_10405	COG4956	integral membrane protein (PIN domain superfamily)
C7K43_10415	COG0756	dUTP diphosphatase activity
C7K43_10420	COG0656	L-ascorbic acid biosynthetic process
C7K43_10425	COG3949	Membrane
C7K43_10435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C7K43_10440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7K43_10455	COG0488	(ABC) transporter
C7K43_10465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7K43_10470	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C7K43_10475	COG0305	Participates in initiation and elongation during chromosome replication
C7K43_10480	COG0359	binds to the 23S rRNA
C7K43_10490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7K43_10495	COG0629	single-stranded DNA binding
C7K43_10500	COG0360	Binds together with S18 to 16S ribosomal RNA
C7K43_10505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7K43_10510	COG0187	DNA topoisomerase II activity
C7K43_10515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7K43_10520	COG2501	S4 domain
C7K43_10525	COG0592	DNA-directed DNA polymerase activity
C7K43_10530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7K43_10540	COG0594	ribonuclease P activity
C7K43_10545	COG0706	membrane insertase activity
C7K43_10560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7K43_10565	COG0445	tRNA wobble uridine modification
C7K43_10580	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_10585	COG2271	Major facilitator Superfamily
C7K43_10595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C7K43_10620	COG1380	Effector of murein hydrolase LrgA
C7K43_10625	COG1346	cytolysis
C7K43_10630	COG1304	FMN binding
C7K43_10650	COG1442	glycosyl transferase family 8
C7K43_10655	COG0357	Ribosomal RNA small subunit methyltransferase G
C7K43_10660	COG1192	Involved in chromosome partitioning
C7K43_10665	COG1475	DNA binding
C7K43_10670	COG4481	Protein conserved in bacteria
C7K43_10675	COG0012	GTP binding
C7K43_10690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7K43_10765	COG1162	GTPase activity
C7K43_10770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K43_10780	COG1792	Involved in formation and maintenance of cell shape
C7K43_10800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C7K43_10805	COG0783	Belongs to the Dps family
C7K43_10820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7K43_10830	COG0488	(ABC) transporter
C7K43_10835	COG0577	efflux transmembrane transporter activity
C7K43_10835	COG1136	(ABC) transporter
C7K43_10840	COG0366	Alpha amylase catalytic
C7K43_10845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7K43_10850	COG0335	large ribosomal subunit rRNA binding
C7K43_10855	COG0789	Transcriptional regulator
C7K43_10860	COG0183	Belongs to the thiolase family
C7K43_10865	COG0300	oxidoreductase activity
C7K43_10870	COG4584	PFAM Integrase catalytic
C7K43_10870	COG2390	Transcriptional regulator
C7K43_10875	COG1484	DNA-dependent DNA replication
C7K43_10880	COG3655	Transcriptional regulator
C7K43_10915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7K43_10925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K43_10930	COG0471	metal ion transport
C7K43_10940	COG2213	PTS system mannitol-specific
C7K43_10945	COG3711	transcriptional antiterminator
C7K43_10950	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_10955	COG0246	Mannitol dehydrogenase
C7K43_10960	COG0363	glucosamine-6-phosphate deaminase activity
C7K43_10965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7K43_10970	COG4109	DRTGG domain
C7K43_10975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7K43_10990	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_11005	COG0531	amino acid
C7K43_11015	COG1053	succinate dehydrogenase
C7K43_11040	COG1408	metallophosphoesterase
C7K43_11050	COG0084	hydrolase, TatD family'
C7K43_11055	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C7K43_11060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7K43_11070	COG0738	Major facilitator superfamily
C7K43_11075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7K43_11115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7K43_11120	COG1121	(ABC) transporter
C7K43_11125	COG1914	H( )-stimulated, divalent metal cation uptake system
C7K43_11160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7K43_11165	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C7K43_11170	COG1472	Belongs to the glycosyl hydrolase 3 family
C7K43_11195	COG4175	Glycine betaine
C7K43_11195	COG3448	diguanylate cyclase activity
C7K43_11210	COG5039	Polysaccharide pyruvyl transferase
C7K43_11220	COG2261	transglycosylase associated protein
C7K43_11235	COG1132	(ABC) transporter
C7K43_11240	COG1132	(ABC) transporter
C7K43_11245	COG2249	NAD(P)H dehydrogenase (quinone) activity
C7K43_11265	COG3711	transcriptional antiterminator
C7K43_11270	COG2190	(PTS) system
C7K43_11270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_11270	COG1263	PTS System
C7K43_11280	COG0739	heme binding
C7K43_11280	COG0741	lytic transglycosylase activity
C7K43_11280	COG1196	nuclear chromosome segregation
C7K43_11285	COG0628	permease
C7K43_11290	COG1388	LysM domain
C7K43_11290	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K43_11310	COG1316	TRANSCRIPTIONal
C7K43_11315	COG3944	biosynthesis protein
C7K43_11320	COG0489	protein tyrosine kinase activity
C7K43_11325	COG4464	protein tyrosine phosphatase activity
C7K43_11335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7K43_11345	COG0438	transferase activity, transferring glycosyl groups
C7K43_11360	COG0463	Glycosyl transferase, family 2
C7K43_11430	COG0210	DNA helicase
C7K43_11455	COG1484	DNA-dependent DNA replication
C7K43_11460	COG1263	PTS System
C7K43_11460	COG2190	(PTS) system
C7K43_11460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_11465	COG2002	toxin-antitoxin pair type II binding
C7K43_11530	COG2050	protein possibly involved in aromatic compounds catabolism
C7K43_11535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C7K43_11540	COG0318	PFAM AMP-dependent synthetase and ligase
C7K43_11575	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K43_11580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_11580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_11580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_11585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_11590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_11590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_11600	COG3620	sequence-specific DNA binding
C7K43_11650	COG1609	Transcriptional regulator
C7K43_11655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K43_11660	COG1869	D-ribose catabolic process
C7K43_11665	COG1129	ABC transporter
C7K43_11670	COG1172	Belongs to the binding-protein-dependent transport system permease family
C7K43_11675	COG1879	ABC-type sugar transport system periplasmic component
C7K43_11680	COG1940	carbohydrate kinase activity
C7K43_11680	COG1846	Transcriptional regulator
C7K43_11690	COG1070	Carbohydrate kinase
C7K43_11705	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_11710	COG3715	PTS system
C7K43_11715	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_11745	COG2814	Major facilitator Superfamily
C7K43_11765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7K43_11770	COG1373	ATPase (AAA superfamily
C7K43_11805	COG1518	maintenance of DNA repeat elements
C7K43_11810	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C7K43_11820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7K43_11825	COG3835	regulator
C7K43_11830	COG1953	Uracil, thiamine, allantoin
C7K43_11845	COG0668	transmembrane transport
C7K43_11855	COG0095	Lipoate-protein ligase
C7K43_11860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7K43_11865	COG2011	ABC-type metal ion transport system permease component
C7K43_11875	COG0583	DNA-binding transcription factor activity
C7K43_11885	COG2059	Chromate
C7K43_11910	COG0191	fructose-bisphosphate aldolase activity
C7K43_11925	COG3715	PTS system
C7K43_11930	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_11935	COG1349	DNA-binding transcription factor activity
C7K43_11955	COG1914	H( )-stimulated, divalent metal cation uptake system
C7K43_11965	COG2337	Toxic component of a toxin-antitoxin (TA) module
C7K43_11975	COG3711	transcriptional antiterminator
C7K43_11975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_11985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_11990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_11990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_11990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_11995	COG0383	alpha-mannosidase activity
C7K43_12040	COG2190	(PTS) system
C7K43_12040	COG1263	PTS System
C7K43_12040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_12050	COG3711	transcriptional antiterminator
C7K43_12100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K43_12105	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C7K43_12110	COG2390	Transcriptional regulator
C7K43_12120	COG0657	acetylesterase activity
C7K43_12120	COG2755	lipolytic protein G-D-S-L family
C7K43_12135	COG0561	phosphatase activity
C7K43_12140	COG4297	protein containing double-stranded beta helix domain
C7K43_12155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7K43_12175	COG1012	belongs to the aldehyde dehydrogenase family
C7K43_12175	COG1454	alcohol dehydrogenase
C7K43_12190	COG4166	transmembrane transport
C7K43_12195	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7K43_12205	COG1737	Transcriptional regulator
C7K43_12210	COG1486	melibiose metabolic process
C7K43_12215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_12215	COG1263	PTS System
C7K43_12220	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C7K43_12230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_12250	COG0191	fructose-bisphosphate aldolase activity
C7K43_12260	COG3711	transcriptional antiterminator
C7K43_12270	COG3414	Phosphotransferase system galactitol-specific IIB component
C7K43_12275	COG3775	system Galactitol-specific IIC component
C7K43_12285	COG0235	Class ii aldolase
C7K43_12305	COG0582	viral genome integration into host DNA
C7K43_12325	COG0783	Belongs to the Dps family
C7K43_12330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K43_12340	COG2188	Transcriptional regulator
C7K43_12380	COG0662	Cupin 2, conserved barrel domain protein
C7K43_12385	COG4619	ABC transporter
C7K43_12390	COG0390	transport system, permease component
C7K43_12405	COG0783	Belongs to the Dps family
C7K43_12410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K43_12420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7K43_12425	COG2217	Heavy metal translocating P-type atpase
C7K43_12470	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
C7K43_12525	COG3964	amidohydrolase
C7K43_12540	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C7K43_12545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K43_12550	COG2233	PERMEase
C7K43_12560	COG0163	prenyltransferase activity
C7K43_12565	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C7K43_12570	COG0583	DNA-binding transcription factor activity
C7K43_12575	COG1940	carbohydrate kinase activity
C7K43_12580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K43_12595	COG3344	reverse transcriptase
C7K43_12600	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C7K43_12605	COG1120	ATPase activity
C7K43_12610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K43_12615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K43_12625	COG0477	Major facilitator Superfamily
C7K43_12630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C7K43_12635	COG0492	ferredoxin-NADP+ reductase activity
C7K43_12645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7K43_12650	COG1185	polyribonucleotide nucleotidyltransferase activity
C7K43_12695	COG0583	DNA-binding transcription factor activity
C7K43_12705	COG4221	oxidoreductase activity
C7K43_12710	COG0656	L-ascorbic acid biosynthetic process
C7K43_12745	COG0745	RESPONSE REGULATOR receiver
C7K43_12750	COG2205	protein histidine kinase activity
C7K43_12795	COG0798	PFAM Bile acid sodium symporter
C7K43_12800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7K43_12820	COG1063	alcohol dehydrogenase
C7K43_12830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K43_12835	COG2315	Protein conserved in bacteria
C7K43_12840	COG0431	NADPH-dependent FMN reductase
C7K43_12850	COG0667	Aldo Keto reductase
C7K43_12855	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_12860	COG2207	Transcriptional regulator
C7K43_12860	COG1917	Cupin 2, conserved barrel domain protein
C7K43_12865	COG2814	Major facilitator Superfamily
C7K43_12870	COG1063	alcohol dehydrogenase
C7K43_12885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C7K43_12890	COG0667	Aldo Keto reductase
C7K43_12895	COG0789	Transcriptional regulator
C7K43_12900	COG0656	L-ascorbic acid biosynthetic process
C7K43_12905	COG2188	Transcriptional regulator
C7K43_12920	COG3594	Acyltransferase
C7K43_12925	COG3579	cysteine-type endopeptidase activity
C7K43_12930	COG2814	Major facilitator Superfamily
C7K43_12935	COG1823	symporter activity
C7K43_12955	COG0582	viral genome integration into host DNA
C7K43_13020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7K43_13165	COG3316	Transposase and inactivated derivatives
C7K43_13205	COG3316	Transposase and inactivated derivatives