locus-tag class description GLW17_00015 ENOG4108HKT sucrose-6-phosphate hydrolase GLW17_00030 ENOG4105CID antiterminator GLW17_00050 ENOG4107PP3 Acetylornithine deacetylase GLW17_00065 ENOG4105ETZ PTS System GLW17_00070 ENOG4105F3R pts system mannose fructose sorbose family iid GLW17_00105 ENOG4105CG3 alpha amylase, catalytic region GLW17_00155 ENOG4106DSS Tartrate dehydratase subunit alpha GLW17_00160 ENOG4107GFK fumarate GLW17_00165 ENOG4105C8P )-transporter GLW17_00170 ENOG4105C5Y PTS System GLW17_00195 ENOG4105CS2 ec 3.2.1.21 GLW17_00200 ENOG4105CK1 PTS System GLW17_00220 ENOG4105F8D glycoside hydrolase family 4 GLW17_00225 ENOG4108Q3X Transcriptional regulator GLW17_00235 ENOG4105CH7 arginosuccinase GLW17_00250 ENOG4108WBT adenosyltransferase GLW17_00255 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GLW17_00275 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GLW17_00295 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GLW17_00300 ENOG4105CQW ribosome biogenesis GTPase YqeH GLW17_00305 ENOG410812S Rna-binding protein GLW17_00310 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GLW17_00315 ENOG4108WF2 Metal Dependent Phosphohydrolase GLW17_00325 ENOG4105DXX methyltransferase GLW17_00330 ENOG4105CDE UPF0348 protein GLW17_00335 ENOG4105CDY transcriptional regulatory protein GLW17_00355 ENOG4105EEM helicase GLW17_00380 ENOG4105K78 MarR family Transcriptional regulator GLW17_00385 ENOG4105C22 threonyL-tRNA synthetase GLW17_00390 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GLW17_00395 ENOG4105CHV Transcription elongation factor NusA GLW17_00400 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GLW17_00415 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GLW17_00420 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GLW17_00425 ENOG4105DTN riboflavin biosynthesis protein ribF GLW17_00445 ENOG4105CSA Coproporphyrinogen iii oxidase GLW17_00450 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GLW17_00455 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GLW17_00460 ENOG4105CFG Acts as a chaperone (By similarity) GLW17_00465 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GLW17_00470 ENOG4105CDA abc transporter atp-binding protein GLW17_00475 ENOG4105EAD ABC transporter GLW17_00480 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GLW17_00485 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GLW17_00490 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GLW17_00500 ENOG4105CIE May be required for sporulation (By similarity) GLW17_00510 ENOG4105C8B TIGR00159 family GLW17_00540 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination GLW17_00545 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GLW17_00555 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GLW17_00560 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GLW17_00565 ENOG4105C31 Tryptophanyl-tRNA synthetase GLW17_00570 ENOG4105CDA abc transporter atp-binding protein GLW17_00575 ENOG4105CT1 (ABC) transporter GLW17_00580 ENOG4105EAD ABC transporter GLW17_00585 ENOG4105DRP amino acid AbC transporter GLW17_00590 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GLW17_00595 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GLW17_00610 ENOG4105D8X mechanosensitive ion channel GLW17_00615 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GLW17_00620 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GLW17_00635 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GLW17_00645 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GLW17_00650 ENOG4108IXY short-chain dehydrogenase reductase GLW17_00655 ENOG41067VP Protein of unknown function (DUF1049) GLW17_00660 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GLW17_00665 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GLW17_00675 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GLW17_00680 ENOG4105VPS UPF0291 protein GLW17_00690 ENOG4107X35 defense response to bacterium GLW17_00695 ENOG4105G5W regulator Fur family GLW17_00705 ENOG4105BZ4 penicillin-binding protein GLW17_00710 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GLW17_00715 ENOG4108UKS UPF0398 protein GLW17_00720 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) GLW17_00730 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GLW17_00765 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GLW17_00780 ENOG4105C94 Transporter GLW17_00790 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GLW17_00805 ENOG4105CTD carboxy-peptidase GLW17_00820 ENOG4105C1J atp-dependent rna helicase GLW17_00835 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GLW17_00850 ENOG4105VND Ribonuclease GLW17_00860 ENOG4105CKU formyltetrahydrofolate synthetase GLW17_00870 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GLW17_00875 ENOG4105C34 Pseudouridine synthase GLW17_00880 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GLW17_00895 ENOG4105CD3 dihydroorotase GLW17_00900 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GLW17_00905 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GLW17_00910 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GLW17_00915 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GLW17_00925 ENOG4105F23 Fibronectin-binding protein GLW17_00940 ENOG4105C7J ABC transporter, permease GLW17_00945 ENOG4108JJB ABC transporter GLW17_00950 ENOG4105E2X shikimate dehydrogenase GLW17_00955 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase GLW17_00960 ENOG4105D49 3-dehydroquinate synthase GLW17_00965 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GLW17_00980 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GLW17_00985 ENOG4105CQC Prephenate dehydratase GLW17_00995 ENOG4108RCF TRANSCRIPTIONal GLW17_01000 ENOG4105EPR degv family GLW17_01030 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GLW17_01035 ENOG4108UIN ybak prolyl-trna synthetase associated region GLW17_01045 ENOG4105C5I Dehydrogenase GLW17_01050 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase GLW17_01055 ENOG4105CH6 catalase GLW17_01075 ENOG4105C26 Dehydrogenase GLW17_01110 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GLW17_01140 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GLW17_01145 ENOG4105VG1 fes assembly suf system protein GLW17_01150 ENOG4105DVT helicase GLW17_01155 ENOG4105C5X domain protein GLW17_01160 ENOG4105CVJ phosphoglycerate mutase GLW17_01170 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GLW17_01175 ENOG4107GRR phosphate transport regulator GLW17_01180 ENOG4105CJ3 phosphate transporter GLW17_01185 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GLW17_01190 ENOG4105TQK DNA polymerase iii, delta' subunit GLW17_01195 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GLW17_01200 ENOG4108UK2 deaminase GLW17_01205 ENOG4105KQC Competence protein GLW17_01215 ENOG4105CHM Aminotransferase GLW17_01220 ENOG4105CDA abc transporter atp-binding protein GLW17_01225 ENOG4105E5Q amino acid AbC transporter GLW17_01230 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GLW17_01235 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GLW17_01245 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GLW17_01255 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GLW17_01265 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GLW17_01270 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GLW17_01275 ENOG4105C4R Atp-dependent dna helicase GLW17_01280 ENOG4105CMQ Chloride channel GLW17_01285 ENOG4105E98 transcriptional regulator DeoR family GLW17_01290 ENOG4105DE4 1-phosphofructokinase GLW17_01295 ENOG4105DM4 PTS System GLW17_01300 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GLW17_01305 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GLW17_01310 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GLW17_01320 ENOG4105VK3 rdd domain containing protein GLW17_01330 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GLW17_01340 ENOG4105M2Z protein tyrosine serine phosphatase GLW17_01350 ENOG4105DZC cytosine deaminase GLW17_01355 ENOG4107QID Threonine synthase GLW17_01360 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GLW17_01380 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GLW17_01390 ENOG4105C02 permease GLW17_01395 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GLW17_01410 ENOG4105EGD dinuclear metal center protein, YbgI family GLW17_01430 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GLW17_01435 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GLW17_01445 ENOG4105C2M dna polymerase I GLW17_01450 ENOG4105HFZ Membrane GLW17_01460 ENOG4105DFU Cell wall formation (By similarity) GLW17_01465 ENOG410906U SprT-like GLW17_01490 ENOG41063PX domain protein GLW17_01495 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GLW17_01500 ENOG4106H78 methyltransferase GLW17_01505 ENOG4105WUC UPF0298 protein GLW17_01520 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GLW17_01525 ENOG4105CNI cell division protein FtsW GLW17_01530 ENOG4105ZPI UPF0358 protein GLW17_01535 ENOG4105CI3 gtp-binding protein typa GLW17_01540 ENOG4105ECY inositol monophosphatase GLW17_01545 ENOG4105WBI UPF0223 protein GLW17_01555 ENOG4105C7S Dehydrogenase GLW17_01570 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GLW17_01575 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) GLW17_01580 ENOG4107QM2 Aldo Keto reductase GLW17_01585 ENOG4105C83 adenylosuccinate lyase GLW17_01590 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GLW17_01595 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GLW17_01605 ENOG4105DY9 regulatoR GLW17_01610 ENOG4108HRK Histidine kinase GLW17_01620 ENOG4107X35 defense response to bacterium GLW17_01625 ENOG4108VXD carboxy-peptidase GLW17_01645 ENOG4105CE4 GlcNAc 6-P deacetylase GLW17_01655 ENOG4105CHM Aminotransferase GLW17_01680 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GLW17_01690 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GLW17_01695 ENOG4105F1A Pyruvate formate-lyase GLW17_01710 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GLW17_01715 ENOG4105K4P CoA-binding domain protein GLW17_01720 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GLW17_01730 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) GLW17_01735 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GLW17_01740 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GLW17_01745 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GLW17_01750 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GLW17_01755 ENOG4105C79 DNA protecting protein DprA GLW17_01760 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GLW17_01765 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GLW17_01800 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GLW17_01815 ENOG4105VSD UPF0346 protein GLW17_01825 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) GLW17_01830 ENOG41090WU lipolytic protein G-D-S-L family GLW17_01835 ENOG4108RCR degv family GLW17_01845 ENOG4108UT2 hemolysin iii GLW17_01860 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GLW17_01865 ENOG4105C5H ABC transporter GLW17_01870 ENOG4107RF6 penicillin-binding protein GLW17_01875 ENOG4108KGH TRANSCRIPTIONal GLW17_01885 ENOG4105EY8 ABC transporter GLW17_01895 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase GLW17_01905 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GLW17_01915 ENOG4105WH5 Teichoic acid glycosylation protein GLW17_01925 ENOG4105C5I Dehydrogenase GLW17_01935 ENOG4107RES phosphoglycerol transferase I GLW17_01940 ENOG4105W8X HesB YadR YfhF-family protein GLW17_01945 ENOG4107ZYR domain protein GLW17_01950 ENOG4105WH1 Two component transcriptional regulator luxr family GLW17_01955 ENOG4105ENE Histidine kinase GLW17_01965 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GLW17_02005 ENOG4107VDP teichoic acid biosynthesis GLW17_02020 ENOG4107SJB teichoic acid biosynthesis GLW17_02030 ENOG4107RZX Teichoic acid biosynthesis protein GLW17_02040 ENOG4107SJB teichoic acid biosynthesis GLW17_02065 ENOG4107SJB teichoic acid biosynthesis GLW17_02080 ENOG4105EKQ RNA-directed DNA polymerase GLW17_02095 ENOG4107RZX Teichoic acid biosynthesis protein GLW17_02100 ENOG4105EJJ Dehydrogenase GLW17_02105 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GLW17_02110 ENOG4105C5S asparaginyl-tRNA synthetase GLW17_02115 ENOG4105CHM Aminotransferase GLW17_02125 ENOG4105DVT helicase GLW17_02130 ENOG4105VEQ Cold shock protein GLW17_02145 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GLW17_02170 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GLW17_02175 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GLW17_02180 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GLW17_02215 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GLW17_02275 ENOG41083X2 DNA polymerase III, epsilon subunit GLW17_02280 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GLW17_02295 ENOG41060M0 Crispr-associated protein, cse4 family GLW17_02325 ENOG4105CK1 PTS System GLW17_02330 ENOG4105VCP PTS System GLW17_02335 ENOG4105VZJ PTS System GLW17_02340 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GLW17_02345 ENOG4105FDU atp-dependent rna helicase GLW17_02350 ENOG4105EE0 oxidoreductase GLW17_02385 ENOG4108RWN rrna methyltransferase GLW17_02390 ENOG410855V Acylphosphatase GLW17_02395 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) GLW17_02405 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GLW17_02410 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GLW17_02415 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) GLW17_02420 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GLW17_02425 ENOG4107YR5 Diacylglycerol kinase GLW17_02430 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GLW17_02440 ENOG4105C9A Phoh family GLW17_02445 ENOG4105KTH gatB Yqey GLW17_02450 ENOG4105VCC 30S ribosomal protein S21 GLW17_02460 ENOG4108JU6 CBS domain protein GLW17_02465 ENOG4105N80 Ferric uptake regulator, Fur family GLW17_02470 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GLW17_02475 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GLW17_02480 ENOG4105D6E homoserine dehydrogenase GLW17_02485 ENOG4105KTU Transcriptional regulator, arsr family GLW17_02495 ENOG4105CS2 ec 3.2.1.21 GLW17_02500 ENOG4108X4Q Hydrolase GLW17_02515 ENOG4105VXM UPF0154 protein GLW17_02525 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GLW17_02535 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GLW17_02550 ENOG4105ETE Transcriptional regulator (LacI family GLW17_02555 ENOG4105DC7 peptidase M24 GLW17_02575 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GLW17_02580 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GLW17_02585 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GLW17_02590 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GLW17_02615 ENOG4108IG5 Transcriptional regulator GLW17_02620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GLW17_02625 ENOG4105BZU Histidine kinase GLW17_02630 ENOG4105CVA phosphate GLW17_02635 ENOG41086DT Membrane protein of unknown function GLW17_02650 ENOG4108UTW Plays a role in the regulation of phosphate uptake GLW17_02655 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GLW17_02660 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GLW17_02665 ENOG4105E2Z phosphate ABC transporter (Permease GLW17_02670 ENOG4105C8U phosphate abc transporter GLW17_02675 ENOG4105CVA phosphate GLW17_02690 ENOG4105CRP Part of the ABC transporter FtsEX involved in GLW17_02695 ENOG4105CAK Cell division ATP-binding protein ftsE GLW17_02705 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GLW17_02725 ENOG4105VZJ PTS System GLW17_02735 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GLW17_02740 ENOG4105FDP GntR family transcriptional regulator GLW17_02760 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GLW17_02770 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GLW17_02785 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GLW17_02800 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GLW17_02815 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GLW17_02820 ENOG4105EKQ RNA-directed DNA polymerase GLW17_02830 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GLW17_02840 ENOG4105XZU Preprotein translocase, subunit SecG GLW17_02845 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GLW17_02850 ENOG4105CP7 Triose-phosphate isomerase GLW17_02855 ENOG4105BZA Phosphoglycerate kinase GLW17_02870 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GLW17_02890 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GLW17_02895 ENOG4105DCI Phosphohydrolase GLW17_02900 ENOG4105E09 nadh pyrophosphatase GLW17_02915 ENOG4105K63 Thioredoxin GLW17_02920 ENOG4105C98 muts2 protein GLW17_02935 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GLW17_02945 ENOG4105CAH Chromate GLW17_02970 ENOG4108IJ7 Glycine betaine GLW17_02980 ENOG4107QQ3 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GLW17_02985 ENOG4105D01 (LipO)protein GLW17_02995 ENOG4105VPH UPF0473 protein GLW17_03000 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GLW17_03005 ENOG4105VBH UPF0297 protein GLW17_03010 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GLW17_03015 ENOG4105C5H ABC transporter GLW17_03020 ENOG4105DCF alanine dehydrogenase GLW17_03025 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GLW17_03030 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GLW17_03040 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GLW17_03045 ENOG4105FH5 Membrane GLW17_03055 ENOG4105DU0 nucleoside hydrolase GLW17_03070 ENOG4105DT3 PTS system, galactitol-specific IIc component GLW17_03075 ENOG41090UW PTS System GLW17_03085 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GLW17_03105 ENOG4105DZR Type I site-specific deoxyribonuclease GLW17_03145 ENOG4105E5Q amino acid AbC transporter GLW17_03150 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein GLW17_03155 ENOG4105E4P ATPase (AAA GLW17_03190 ENOG4108JYZ YitT family GLW17_03200 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GLW17_03210 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GLW17_03220 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GLW17_03225 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GLW17_03245 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GLW17_03250 ENOG4105KVH Transcriptional regulator GLW17_03255 ENOG4105C19 ABC transporter GLW17_03275 ENOG4105GR3 Histidine kinase GLW17_03280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GLW17_03290 ENOG4106IPI cyclase, family GLW17_03320 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GLW17_03345 ENOG4105CIS alcohol dehydrogenase GLW17_03355 ENOG41082BM Transcriptional regulator, arsr family GLW17_03365 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GLW17_03385 ENOG4105CG3 alpha amylase, catalytic region GLW17_03400 ENOG4108W5M transcriptional regulator GLW17_03405 ENOG4105VBF alkaline shock protein GLW17_03425 ENOG4105VBF alkaline shock protein GLW17_03435 ENOG4105D2N Aldolase GLW17_03450 ENOG4105DKT Transcriptional regulator GLW17_03475 ENOG41082DI 50s ribosomal protein l31 GLW17_03480 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GLW17_03485 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GLW17_03495 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GLW17_03500 ENOG4105C5F glutamine synthetase GLW17_03505 ENOG4105KV4 Transcriptional regulator GLW17_03510 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GLW17_03515 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GLW17_03520 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GLW17_03535 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GLW17_03540 ENOG4108Z0R Transferase GLW17_03545 ENOG4105BZ1 (ABC) transporter GLW17_03555 ENOG4106EHS UPF0356 protein GLW17_03570 ENOG4105W5Q DNA repair protein (RadC GLW17_03575 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GLW17_03580 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GLW17_03585 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GLW17_03590 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GLW17_03595 ENOG4108YWR Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GLW17_03600 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GLW17_03605 ENOG4105C3J Cysteine desulfurase GLW17_03615 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) GLW17_03620 ENOG4105CFH Aspartokinase GLW17_03630 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) GLW17_03640 ENOG4108X4Q Hydrolase GLW17_03645 ENOG4105I3N Conserved Protein GLW17_03650 ENOG4105HDK L-asparaginase GLW17_03665 ENOG4105EQ0 Major Facilitator superfamily GLW17_03680 ENOG4105CTZ aminopeptidase c GLW17_03685 ENOG4108TGC Acyltransferase GLW17_03720 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GLW17_03725 ENOG4105CFC Transporter GLW17_03730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GLW17_03750 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GLW17_03755 ENOG4108IV0 ABC, transporter GLW17_03760 ENOG4105C0Z ABC transporter GLW17_03765 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GLW17_03770 ENOG4105C32 Amino acid ABC transporter (Permease) GLW17_03780 ENOG4105D9N nucleoside GLW17_03795 ENOG4108Q5F Tetr family transcriptional regulator GLW17_03820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GLW17_03835 ENOG4105SX7 Transporter GLW17_03870 ENOG4105EZV Transcriptional regulator GLW17_03875 ENOG4106AXJ AraC family transcriptional regulator GLW17_03885 ENOG4108ZHR arsR family transcriptional regulator GLW17_03890 ENOG4105C0R drug resistance transporter emrb qaca subfamily GLW17_03900 ENOG4108V4B ThiJ pfpI GLW17_03905 ENOG4105C59 p-type ATPase GLW17_03920 ENOG4105IJJ transcriptional regulator, crp fnr family GLW17_03925 ENOG4105HUF DNA protection during starvation protein GLW17_03975 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GLW17_04015 ENOG4105C87 Aminotransferase class I and II GLW17_04025 ENOG4105CAY ferredoxin--nadp reductase GLW17_04030 ENOG4108W5N phosphatidylglycerophosphatase a GLW17_04035 ENOG4105C0R drug resistance transporter emrb qaca subfamily GLW17_04040 ENOG4105EKQ RNA-directed DNA polymerase GLW17_04045 ENOG4105EHG Permease protein GLW17_04050 ENOG4105DQ5 transport system permease protein GLW17_04055 ENOG4105E0A ABC, transporter GLW17_04060 ENOG4108HUF Transporter GLW17_04065 ENOG4105UP7 3-epimerase GLW17_04070 ENOG41066F8 ROK family GLW17_04075 ENOG4105C2W permease GLW17_04080 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GLW17_04105 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GLW17_04110 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine GLW17_04115 ENOG4105F3R pts system mannose fructose sorbose family iid GLW17_04120 ENOG4105ETZ PTS System GLW17_04135 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) GLW17_04145 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GLW17_04150 ENOG41082GB PTS system galactitol-specific transporter subunit IIA GLW17_04155 ENOG4105CID antiterminator GLW17_04175 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GLW17_04185 ENOG4106ETB IIa component GLW17_04190 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) GLW17_04200 ENOG4105EKQ RNA-directed DNA polymerase GLW17_04205 ENOG4108EKI Dehydrogenase GLW17_04225 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GLW17_04230 ENOG4105Q95 Cupin 2, conserved barrel domain protein GLW17_04240 ENOG4105DJB Major Facilitator Superfamily GLW17_04255 ENOG4107RHR regulatoR GLW17_04260 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GLW17_04265 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GLW17_04285 ENOG4105C59 p-type ATPase GLW17_04295 ENOG4105C7N Xanthine uracil vitamin C permease GLW17_04310 ENOG4105CIG ABC transporter GLW17_04315 ENOG4105CIG ABC transporter GLW17_04345 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GLW17_04390 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GLW17_04420 ENOG4105CMT Dihydroxyacetone kinase GLW17_04425 ENOG4105VDH Dihydroxyacetone kinase GLW17_04445 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GLW17_04455 ENOG4108S3Y transcriptional regulator GLW17_04460 ENOG4105C5Y PTS System GLW17_04465 ENOG4105CS2 ec 3.2.1.21 GLW17_04480 ENOG4105C0R drug resistance transporter emrb qaca subfamily GLW17_04485 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GLW17_04500 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GLW17_04505 ENOG4105EV1 Ribose uptake protein RbsU GLW17_04525 ENOG4107RGD Major Facilitator superfamily GLW17_04545 ENOG4105FE1 phytoene synthase GLW17_04550 ENOG41062JF Transcriptional regulator GLW17_04555 ENOG4108JB8 alcohol dehydrogenase GLW17_04560 ENOG4105C26 Dehydrogenase GLW17_04565 ENOG4105TRT Transcriptional regulator GLW17_04620 ENOG4105ETD TRANSCRIPTIONal GLW17_04625 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GLW17_04630 ENOG4107QM2 Aldo Keto reductase GLW17_04635 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GLW17_04640 ENOG4105DT3 PTS system, galactitol-specific IIc component GLW17_04705 ENOG4105KRN Transcriptional regulator, abrb family GLW17_04710 ENOG4105C5Y PTS System GLW17_04720 ENOG4105CID antiterminator GLW17_04830 ENOG4105G15 CRISPR-associated RAMP protein, Csm5 family GLW17_04835 ENOG4108T47 CRISPR-associated RAMP protein, Csm4 family GLW17_04840 ENOG4108W8W CRISPR-associated RAMP protein, Csm3 family GLW17_04855 ENOG4105GIM CRISPR-associated protein cas6 GLW17_05020 ENOG4105CMR udp-glucose 4-epimerase GLW17_05025 ENOG4108PQP glycosyl transferase group 1 GLW17_05030 ENOG4105D3Q Sugar transferase GLW17_05035 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GLW17_05050 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GLW17_05055 ENOG4108QV3 biosynthesis protein GLW17_05060 ENOG4105HTX biosynthesis protein GLW17_05065 ENOG4108KGH TRANSCRIPTIONal GLW17_05085 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase GLW17_05110 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GLW17_05120 ENOG4107BMA Transglycosylase associated protein GLW17_05140 ENOG4108IJ7 Glycine betaine GLW17_05165 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GLW17_05170 ENOG4105X71 Membrane GLW17_05175 ENOG4105DYB Isoaspartyl dipeptidase GLW17_05180 ENOG4105CSX c4-dicarboxylate anaerobic carrier GLW17_05200 ENOG4105RNB GLW17_05205 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GLW17_05210 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GLW17_05215 ENOG4105F8V Hydrolase, tatD family GLW17_05230 ENOG4105DSE periplasmic solute binding protein GLW17_05235 ENOG4105DIK (ABC) transporter GLW17_05255 ENOG4107EFR Flavocytochrome c GLW17_05260 ENOG4107TRN Xylose isomerase domain protein TIM barrel GLW17_05265 ENOG4107R7I amino acid GLW17_05280 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GLW17_05295 ENOG4105SFS phosphoesterase RecJ domain protein GLW17_05305 ENOG4105E8R UPF0173 metal-dependent hydrolase GLW17_05315 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GLW17_05320 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GLW17_05325 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GLW17_05330 ENOG4105ETD TRANSCRIPTIONal GLW17_05335 ENOG4105CTS PTS system mannitol-specific GLW17_05345 ENOG4105C8P )-transporter GLW17_05355 ENOG41086FC 50S ribosomal protein l32 GLW17_05360 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GLW17_05385 ENOG4108IJ7 Glycine betaine GLW17_05390 ENOG4105FDP GntR family transcriptional regulator GLW17_05405 ENOG4105CAQ asparagine synthetase GLW17_05415 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GLW17_05420 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GLW17_05425 ENOG4108IUK alpha amylase, catalytic GLW17_05430 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GLW17_05430 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GLW17_05435 ENOG4105C5H ABC transporter GLW17_05450 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GLW17_05465 ENOG4105EVU fructokinase GLW17_05470 ENOG4108HKT sucrose-6-phosphate hydrolase GLW17_05475 ENOG4105ETE Transcriptional regulator (LacI family GLW17_05490 ENOG4105C72 UPF0176 protein GLW17_05495 ENOG4108MXZ Esterase GLW17_05500 ENOG4105M56 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GLW17_05505 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) GLW17_05525 ENOG4105QD4 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GLW17_05550 ENOG4105KT7 mgtC SapB transporter GLW17_05560 ENOG4105C59 p-type ATPase GLW17_05585 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GLW17_05595 ENOG4105E70 isomerase GLW17_05600 ENOG4105FDP GntR family transcriptional regulator GLW17_05605 ENOG4105D2M Aldolase GLW17_05610 ENOG4105CPQ Dehydrogenase GLW17_05615 ENOG4105DT3 PTS system, galactitol-specific IIc component GLW17_05620 ENOG41090UW PTS System GLW17_05635 ENOG4105DE4 1-phosphofructokinase GLW17_05640 ENOG4108UTZ Dihydroxyacetone kinase GLW17_05645 ENOG4105CMT Dihydroxyacetone kinase GLW17_05650 ENOG4105VDH Dihydroxyacetone kinase GLW17_05655 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GLW17_05660 ENOG4107QRI Phosphoketolase GLW17_05670 ENOG4105K63 Thioredoxin GLW17_05675 ENOG4108V06 Glutathione peroxidase GLW17_05680 ENOG4105K56 Transcriptional regulator GLW17_05685 ENOG4105C3M thioredoxin reductase GLW17_05700 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GLW17_05720 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GLW17_05725 ENOG4107S03 uridine kinase GLW17_05730 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GLW17_05735 ENOG4105C0H protease GLW17_05740 ENOG4108VDD TRNA binding domain protein GLW17_05745 ENOG4107YZX Universal stress protein GLW17_05755 ENOG4105CN9 Peptidase m42 family protein GLW17_05775 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GLW17_05780 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GLW17_05810 ENOG4106855 Competence protein GLW17_05825 ENOG4105EXC Acyl-transferase GLW17_05830 ENOG4107AYK membrAne GLW17_05835 ENOG4105C9M aspartyl-trna synthetase GLW17_05840 ENOG4105CUT histidyl-tRNA synthetase GLW17_05855 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GLW17_05860 ENOG4105VJV 50s ribosomal protein L35 GLW17_05865 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GLW17_05870 ENOG4108J59 Extracellular solute-binding protein, family 5 GLW17_05875 ENOG4105G9B Transcriptional regulator GLW17_05880 ENOG4105DZC cytosine deaminase GLW17_05885 ENOG4105DZC cytosine deaminase GLW17_05890 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GLW17_05895 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GLW17_05910 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GLW17_05920 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GLW17_05930 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GLW17_05955 ENOG4105II7 pyrroline-5-carboxylate reductase GLW17_05965 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GLW17_05970 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GLW17_05975 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GLW17_05980 ENOG4105C1J atp-dependent rna helicase GLW17_05985 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GLW17_05995 ENOG4107XJU UPF0178 protein GLW17_06020 ENOG4105DBI uridine monophosphokinase GLW17_06025 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GLW17_06060 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GLW17_06065 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GLW17_06070 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GLW17_06075 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GLW17_06080 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GLW17_06085 ENOG4107104 thymidine kinase GLW17_06100 ENOG4107Y70 Heat shock protein GLW17_06110 ENOG4105C3F Signal peptidase i GLW17_06120 ENOG4105DMS mur ligase GLW17_06125 ENOG4105F1K Glutamine amidotransferase GLW17_06130 ENOG4105CI1 PTS System GLW17_06140 ENOG4105DG6 mannose-6-phosphate isomerase GLW17_06145 ENOG4107S1E Beta-lactamase GLW17_06155 ENOG4105K59 histidine triad (HIT) protein GLW17_06165 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GLW17_06170 ENOG4105EQI Metal Dependent Phosphohydrolase GLW17_06190 ENOG4105CVM Molybdenum cofactor synthesis domain protein GLW17_06195 ENOG4108IEG Formate dehydrogenase Alpha subunit GLW17_06210 ENOG4105TMB Formate nitrite transporter GLW17_06215 ENOG41080H2 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GLW17_06240 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GLW17_06245 ENOG4105D06 uba thif-type nad fad binding protein GLW17_06250 ENOG4105WZB UPF0342 protein GLW17_06260 ENOG4105BZ4 penicillin-binding protein GLW17_06265 ENOG4108YBP pseudouridine synthase GLW17_06280 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GLW17_06290 ENOG4108ZHJ Organic hydroperoxide resistance protein GLW17_06295 ENOG4105C8T Leucyl-tRNA synthetase GLW17_06305 ENOG410841Q phosphoesterase PA-phosphatase related protein GLW17_06330 ENOG4105DT3 PTS system, galactitol-specific IIc component GLW17_06335 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GLW17_06345 ENOG4108UVJ appr-1-p processing domain protein GLW17_06350 ENOG4108Z0Z intracellular protease Pfpi family GLW17_06360 ENOG4105C5H ABC transporter GLW17_06370 ENOG4105CHR reductase GLW17_06375 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GLW17_06400 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GLW17_06415 ENOG4105EKQ RNA-directed DNA polymerase GLW17_06420 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GLW17_06425 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GLW17_06445 ENOG41088B0 Major membrane immunogen GLW17_06460 ENOG4105EAH synthase GLW17_06465 ENOG4105DC8 reductase GLW17_06470 ENOG4108W0I acetyltransferase GLW17_06475 ENOG4105CFP Peptidase U32 GLW17_06490 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GLW17_06495 ENOG4105KEX transcriptional regulator, ctsr GLW17_06500 ENOG4105D9P serine threonine protein kinase GLW17_06510 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GLW17_06515 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GLW17_06520 ENOG4105C25 Primosomal protein n' GLW17_06525 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GLW17_06530 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GLW17_06550 ENOG4105DWF phosphomethylpyrimidine kinase GLW17_06555 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GLW17_06560 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GLW17_06580 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GLW17_06585 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GLW17_06590 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GLW17_06595 ENOG4105DFT pur operon repressor GLW17_06605 ENOG4105FDK ABC transporter GLW17_06610 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GLW17_06615 ENOG4105C5Y PTS System GLW17_06620 ENOG4105C71 hydrolase family 65, central catalytic GLW17_06625 ENOG4107URF beta-phospho-glucomutase GLW17_06630 ENOG4107414 GntR family transcriptional regulator GLW17_06635 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GLW17_06645 ENOG4105CEV competence damage-inducible protein GLW17_06650 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GLW17_06675 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GLW17_06680 ENOG4105W42 Veg protein GLW17_06690 ENOG4105M0M Tetracycline resistance protein GLW17_06695 ENOG4105C2N RNA methyltransferase TrmH family group 3 GLW17_06700 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) GLW17_06705 ENOG4105C8N cysteinyl-tRNA synthetase GLW17_06710 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GLW17_06715 ENOG4105CTP PilT protein domain protein GLW17_06725 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GLW17_06735 ENOG4105CV8 reductase GLW17_06740 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GLW17_06745 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GLW17_06755 ENOG4105C5H ABC transporter GLW17_06765 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GLW17_06770 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 GLW17_06775 ENOG4105CDU Replicative dna helicase GLW17_06780 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GLW17_06790 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GLW17_06800 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GLW17_06810 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GLW17_06815 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GLW17_06820 ENOG410848D S4 domain protein YaaA GLW17_06825 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GLW17_06830 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GLW17_06835 ENOG4105VG0 50S ribosomal protein l34 GLW17_06840 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GLW17_06845 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GLW17_06860 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GLW17_06865 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GLW17_06895 ENOG41067MG lrgb family GLW17_06930 ENOG4105X1N Glycosyl transferase family 8 GLW17_06935 ENOG4105EKQ RNA-directed DNA polymerase GLW17_06945 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GLW17_06950 ENOG4107QJE Chromosome Partitioning Protein GLW17_06955 ENOG4105FA0 parb-like partition protein GLW17_06960 ENOG4105VDK protein, conserved in bacteria GLW17_06965 ENOG4105C3G gtp-binding protein GLW17_06975 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GLW17_06980 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GLW17_07055 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GLW17_07060 ENOG4105DJV ribulose-phosphate 3-epimerase GLW17_07090 ENOG4105HUF DNA protection during starvation protein GLW17_07100 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GLW17_07105 ENOG4108UJD 30S ribosomal protein S9 GLW17_07110 ENOG4107T66 Releases the N-terminal proline from various substrates (By similarity) GLW17_07125 ENOG4105E98 transcriptional regulator DeoR family GLW17_07160 ENOG4105D2M Aldolase GLW17_07165 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GLW17_07170 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GLW17_07175 ENOG4105CEU Arginine dihydrolase GLW17_07180 ENOG4105DBV ornithine carbamoyltransferase GLW17_07185 ENOG4105C5B carbamate kinase GLW17_07190 ENOG4105IJS Transcriptional regulator GLW17_07195 ENOG4105CSX c4-dicarboxylate anaerobic carrier GLW17_07200 ENOG4108U05 Transcriptional regulator GLW17_07235 ENOG4105C75 arginyL-tRNA synthetase GLW17_07240 ENOG4105EKQ RNA-directed DNA polymerase GLW17_07245 ENOG4105CSC Glucose uptake protein GLW17_07260 ENOG4105C4M (Ubiquinol oxidase) subunit I GLW17_07265 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GLW17_07270 ENOG4108JJ9 ABC, transporter GLW17_07275 ENOG4108JJ8 (ABC) transporter GLW17_07285 ENOG4105DSE periplasmic solute binding protein GLW17_07315 ENOG4105CEP NADH dehydrogenase GLW17_07335 ENOG4105C26 Dehydrogenase GLW17_07350 ENOG4105CDY transcriptional regulatory protein GLW17_07360 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GLW17_07365 ENOG4105EKQ RNA-directed DNA polymerase GLW17_07370 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GLW17_07375 ENOG4108JA2 transcriptioN-repair coupling factor GLW17_07385 ENOG41082I2 s4 domain protein GLW17_07395 ENOG41060GV RNA binding s1 domain protein GLW17_07400 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GLW17_07405 ENOG4108UGV hypoxanthine phosphoribosyltransferase GLW17_07415 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GLW17_07420 ENOG4105CRK lysyL-tRNA synthetase GLW17_07570 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GLW17_07575 ENOG4107UWA esterase GLW17_07585 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GLW17_07590 ENOG4105C5Y PTS System GLW17_07600 ENOG4107QK9 Beta-lactamase GLW17_07610 ENOG4107BJW polysaccharide deacetylase GLW17_07620 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GLW17_07630 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GLW17_07635 ENOG4105VBF alkaline shock protein GLW17_07650 ENOG4105VBF alkaline shock protein GLW17_07660 ENOG4105ST3 Transcriptional regulator GLW17_07670 ENOG4105ST3 Transcriptional regulator GLW17_07675 ENOG4105EYF MMPL domain protein GLW17_07685 ENOG4105ST3 Transcriptional regulator GLW17_07690 ENOG4105EYF MMPL domain protein GLW17_07730 ENOG4105D1H recombination factor protein RarA GLW17_07735 ENOG4105CHF Glutathione S-transferase GLW17_07740 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GLW17_07755 ENOG4105K4I Scp-like extracellular GLW17_07775 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GLW17_07780 ENOG4107QPK )-transporter GLW17_07785 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GLW17_07815 ENOG4107TXC Transcriptional regulator GLW17_07825 ENOG4107YUH hydrolase GLW17_07830 ENOG4108URH decarboxylase GLW17_07835 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain GLW17_07845 ENOG4108Z0Z intracellular protease Pfpi family GLW17_07860 ENOG4105E5Q amino acid AbC transporter GLW17_07865 ENOG4105CDA abc transporter atp-binding protein GLW17_07875 ENOG410667J hydrolase GLW17_07880 ENOG4107QPK )-transporter GLW17_07890 ENOG4105CGK Exodeoxyribonuclease III GLW17_07895 ENOG4105CPF Cell wall formation (By similarity) GLW17_07900 ENOG41082BM Transcriptional regulator, arsr family GLW17_07910 ENOG4105EKQ RNA-directed DNA polymerase GLW17_07915 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GLW17_07920 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) GLW17_07985 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GLW17_07990 ENOG4105CS9 pantothenic acid kinase GLW17_07995 ENOG4107Y49 methyltransferase GLW17_08000 ENOG4105ETE Transcriptional regulator (LacI family GLW17_08005 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GLW17_08010 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GLW17_08015 ENOG4105KG3 cytidine deaminase GLW17_08020 ENOG4105DIH basic membrane GLW17_08025 ENOG4108JQ9 ABC transporter GLW17_08030 ENOG4105UIB (ABC) transporter GLW17_08055 ENOG4107QW4 alcohol dehydrogenase GLW17_08060 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GLW17_08065 ENOG4105E66 phosphoriboisomerase A GLW17_08070 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GLW17_08075 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GLW17_08080 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GLW17_08085 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GLW17_08090 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GLW17_08095 ENOG4105DWF phosphomethylpyrimidine kinase GLW17_08105 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GLW17_08110 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GLW17_08115 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GLW17_08120 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GLW17_08125 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GLW17_08130 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GLW17_08135 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GLW17_08140 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GLW17_08145 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GLW17_08150 ENOG41082SA 50s ribosomal protein l29 GLW17_08155 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GLW17_08160 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GLW17_08165 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GLW17_08170 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GLW17_08175 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GLW17_08180 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GLW17_08185 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GLW17_08190 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GLW17_08195 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GLW17_08200 ENOG4105VPB 50S ribosomal protein L30 GLW17_08205 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GLW17_08210 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GLW17_08215 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GLW17_08220 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GLW17_08225 ENOG41067V7 50S ribosomal protein L36 GLW17_08230 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GLW17_08235 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GLW17_08240 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GLW17_08245 ENOG4108ZT0 50S ribosomal protein l17 GLW17_08250 ENOG4108JJB ABC transporter GLW17_08255 ENOG4108JJB ABC transporter GLW17_08265 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GLW17_08270 ENOG4105C5F glutamine synthetase GLW17_08275 ENOG4105EJV Membrane GLW17_08315 ENOG4105CFC Transporter GLW17_08340 ENOG4105VB9 50S ribosomal protein l28 GLW17_08350 ENOG4105DP4 dak2 domain fusion protein ylov GLW17_08355 ENOG4105CB5 ATP-dependent DNA helicase recG GLW17_08360 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GLW17_08365 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GLW17_08370 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GLW17_08375 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GLW17_08380 ENOG410667J hydrolase GLW17_08385 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GLW17_08405 ENOG4105D9M gamma-glutamylcysteine synthetase GLW17_08420 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GLW17_08430 ENOG4108WQ8 UPF0637 protein GLW17_08435 ENOG4105VKD bioY protein GLW17_08445 ENOG4105DY9 regulatoR GLW17_08460 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GLW17_08470 ENOG4108X4Q Hydrolase GLW17_08485 ENOG4105D48 metallophosphoesterase GLW17_08495 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GLW17_08500 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GLW17_08520 ENOG4105E0X reductase GLW17_08530 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GLW17_08540 ENOG4105KJF protein tyrosine phosphatase GLW17_08550 ENOG4105CWM branched-chain amino acid transport system II carrier protein GLW17_08555 ENOG4105CDA abc transporter atp-binding protein GLW17_08560 ENOG4105E5Q amino acid AbC transporter GLW17_08570 ENOG4108UW5 maltose o-acetyltransferase GLW17_08575 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GLW17_08580 ENOG4108UMI ABC transporter, permease GLW17_08585 ENOG4105D01 (LipO)protein GLW17_08590 ENOG4107YB9 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GLW17_08600 ENOG4105E0C molybdate abc transporter GLW17_08610 ENOG4108RIR Molybdenum cofactor biosynthesis protein GLW17_08615 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GLW17_08630 ENOG4105BZ1 (ABC) transporter GLW17_08650 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GLW17_08670 ENOG410667J hydrolase GLW17_08680 ENOG4107YZX Universal stress protein GLW17_08700 ENOG4105D1H recombination factor protein RarA GLW17_08705 ENOG4108VX5 3-methyladenine DNA glycosylase GLW17_08710 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GLW17_08715 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GLW17_08725 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GLW17_08730 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GLW17_08750 ENOG4107QKV phosphomannomutase GLW17_08755 ENOG4105CUB amino acid GLW17_08760 ENOG4105CDW Resistance protein GLW17_08770 ENOG4105VTR Integrase GLW17_08865 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GLW17_08870 ENOG4105C9K Endothelin-converting enzyme 1 GLW17_08880 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GLW17_08885 ENOG4105C3J Cysteine desulfurase GLW17_08895 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GLW17_08920 ENOG4108IJ9 (ABC) transporter GLW17_08930 ENOG4105E5Q amino acid AbC transporter GLW17_08935 ENOG4105CDA abc transporter atp-binding protein GLW17_08940 ENOG4108HW3 (ABC) transporter GLW17_08945 ENOG4105CNU cell division protein FtsK GLW17_08970 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GLW17_08975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GLW17_08985 ENOG4108JQ7 (ABC) transporter GLW17_08990 ENOG4105D7V transposase GLW17_08995 ENOG4105CJW magnesium transporter GLW17_09005 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GLW17_09010 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GLW17_09025 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GLW17_09045 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GLW17_09050 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GLW17_09070 ENOG4105JRK feS assembly protein SufD GLW17_09075 ENOG4105C9B Cysteine desulfurase GLW17_09080 ENOG4108UNV SUF system FeS assembly protein, NifU family GLW17_09090 ENOG4105BZ1 (ABC) transporter GLW17_09095 ENOG4105BZ1 (ABC) transporter GLW17_09105 ENOG4105CM2 brancheD-chain amino acid aminotransferase GLW17_09125 ENOG4105C9Q fumarate hydratase class II GLW17_09150 ENOG4105C6Z Gluconate GLW17_09155 ENOG4105CMG Carbohydrate kinase GLW17_09160 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GLW17_09170 ENOG4105ZMH deoxynucleoside kinase GLW17_09175 ENOG4105DUX Transporter GLW17_09185 ENOG4105BZ1 (ABC) transporter GLW17_09190 ENOG4105E90 ABC transporter GLW17_09195 ENOG4108IJ8 ABC transporter GLW17_09205 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GLW17_09225 ENOG4105C6T cysteine synthase GLW17_09230 ENOG4107FQX Alpha-acetolactate decarboxylase GLW17_09235 ENOG4107S0N DJ-1 family GLW17_09245 ENOG4105C28 cystathionine GLW17_09250 ENOG4105D7W serine acetyltransferase GLW17_09255 ENOG4107QJZ Glycosyl transferase, family 2 GLW17_09265 ENOG4107QJZ Glycosyl transferase, family 2 GLW17_09275 ENOG4107UVV polysaccharide deacetylase GLW17_09295 ENOG4105DM4 PTS System GLW17_09300 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GLW17_09305 ENOG4105DM4 PTS System GLW17_09310 ENOG4105UP7 3-epimerase GLW17_09320 ENOG4105DIW FeS assembly protein SUFB GLW17_09325 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GLW17_09355 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GLW17_09365 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GLW17_09370 ENOG4105BZ8 glutamate synthase GLW17_09380 ENOG4107RCH Diaminopropionate ammonia-lyase GLW17_09385 ENOG4107S4Y M20 DapE family protein YgeY GLW17_09395 ENOG4105C5B carbamate kinase GLW17_09400 ENOG4105KME endoribonuclease L-psp GLW17_09410 ENOG4105F4R Transcriptional regulator mode GLW17_09430 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein GLW17_09435 ENOG4105BZ8 glutamate synthase GLW17_09445 ENOG4105C7K acetolactate synthase GLW17_09450 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GLW17_09455 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GLW17_09460 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GLW17_09470 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GLW17_09475 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GLW17_09490 ENOG4108Z6B deaminase GLW17_09505 ENOG4107R8B 5'-nucleotidase GLW17_09510 ENOG4105MMD transcriptional regulator GLW17_09515 ENOG4105D4U had-superfamily hydrolase, subfamily iia GLW17_09525 ENOG4105DF9 Lipoate-protein, ligase GLW17_09535 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GLW17_09540 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) GLW17_09545 ENOG4105D6A Electron transport complex GLW17_09565 ENOG4105CIG ABC transporter GLW17_09580 ENOG4105WMR Protein CrcB homolog GLW17_09590 ENOG4105VC4 domain protein GLW17_09595 ENOG41060K3 Methyltransferase GLW17_09600 ENOG4105F6E Acyl-transferase GLW17_09605 ENOG4107RFY SbcCD D subunit GLW17_09610 ENOG4105EYH Exonuclease GLW17_09620 ENOG4105BZ1 (ABC) transporter GLW17_09630 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) GLW17_09635 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis GLW17_09645 ENOG4105DPN Oligoendopeptidase f GLW17_09650 ENOG4105MIX Adenylate cyclase GLW17_09660 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GLW17_09665 ENOG4105EMS pseudouridine synthase GLW17_09670 ENOG4105CJW magnesium transporter GLW17_09675 ENOG4106N3A copper homeostasis protein cutc GLW17_09680 ENOG4105DHI Methyltransferase GLW17_09685 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GLW17_09695 ENOG4105C7H Helicase, RecD TraA family GLW17_09700 ENOG410807C QueT transporter GLW17_09720 ENOG4107FTN 50S ribosomal protein L33 GLW17_09730 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GLW17_09740 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GLW17_09745 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GLW17_09750 ENOG4108VZM 50s ribosomal protein L10 GLW17_09755 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GLW17_09760 ENOG4108RYK Nad-dependent epimerase dehydratase GLW17_09765 ENOG4105CK1 PTS System GLW17_09770 ENOG4105CS2 ec 3.2.1.21 GLW17_09775 ENOG4105C6E dna polymerase iii GLW17_09780 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GLW17_09785 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GLW17_09790 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GLW17_09795 ENOG4105X0R protein from nitrogen regulatory protein P-II GLW17_09800 ENOG4105FA2 dna polymerase iii GLW17_09805 ENOG4105MA4 psp1 domain protein GLW17_09810 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) GLW17_09815 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GLW17_09830 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GLW17_09835 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GLW17_09840 ENOG4105DF9 Lipoate-protein, ligase GLW17_09845 ENOG4105CV8 reductase GLW17_09850 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GLW17_09855 ENOG4108VQJ O-methyltransferase GLW17_09880 ENOG4105K46 50S ribosomal protein l27 GLW17_09890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GLW17_09895 ENOG4108EQA pts system GLW17_09905 ENOG4105ETZ PTS System GLW17_09910 ENOG4105F3R pts system mannose fructose sorbose family iid GLW17_09925 ENOG4105DI5 UPF0365 protein GLW17_09935 ENOG4105DC7 peptidase M24 GLW17_09940 ENOG4108ZSR alkaline shock protein GLW17_09945 ENOG4105M7K Involved in the transcription termination process (By similarity) GLW17_09950 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GLW17_09955 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GLW17_09960 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GLW17_09970 ENOG4105DX0 Hemolysin A GLW17_09975 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GLW17_09980 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GLW17_10000 ENOG4108V6E Cell division protein mraZ GLW17_10015 ENOG4105CJN penicillin-binding protein GLW17_10025 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GLW17_10050 ENOG4105DFA alanine racemase domain protein GLW17_10055 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GLW17_10060 ENOG41067XK integral membrane protein GLW17_10065 ENOG4105DBK s4 domain protein GLW17_10070 ENOG4105MMF Cell division protein DIVIVA GLW17_10075 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GLW17_10080 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GLW17_10090 ENOG4105C88 aminopeptidase GLW17_10100 ENOG4107Z3H Transcriptional regulator, TetR family GLW17_10105 ENOG4105NQC Flavodoxin GLW17_10115 ENOG4107U9T Pfam:Ribonuclease_BN GLW17_10120 ENOG4105ESV Glycosyl transferase, family 4 GLW17_10140 ENOG4105CHM Aminotransferase GLW17_10145 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GLW17_10150 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GLW17_10165 ENOG4105CS1 NAD(P)H quinone oxidoreductase GLW17_10170 ENOG4105K5M 30s ribosomal protein S16 GLW17_10175 ENOG4105VB6 UPF0109 protein GLW17_10185 ENOG4105D9Q decarboxylase (Beta subunit) GLW17_10190 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein GLW17_10200 ENOG4107QSA Oxaloacetate decarboxylase GLW17_10225 ENOG4105DUA (citrate (pro-3S)-lyase ligase GLW17_10230 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) GLW17_10260 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GLW17_10265 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GLW17_10275 ENOG4105VUC UPF0237 protein GLW17_10285 ENOG4108ZGC gaf domain protein GLW17_10305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GLW17_10310 ENOG4105BZU Histidine kinase GLW17_10325 ENOG4105E0M Sulfatase GLW17_10330 ENOG4105DR4 Methyltransferase GLW17_10335 ENOG4105FF2 Type I DHQase GLW17_10340 ENOG4108Z66 YbaK ebsC protein GLW17_10345 ENOG4107R37 Glutamate dehydrogenase GLW17_10350 ENOG4107QYV phosphohexose isomerase GLW17_10380 ENOG4108KP7 hydrolase GLW17_10385 ENOG4105C7N Xanthine uracil vitamin C permease GLW17_10395 ENOG4105C0B DNA polymerase III (alpha subunit) GLW17_10400 ENOG4105CTQ phosphohexokinase GLW17_10405 ENOG4105CA9 Pyruvate kinase GLW17_10415 ENOG41067VY 50S ribosomal protein L32 GLW17_10420 ENOG4105EKQ RNA-directed DNA polymerase GLW17_10445 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GLW17_10450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GLW17_10455 ENOG4105GR3 Histidine kinase GLW17_10540 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) GLW17_10550 ENOG4105EKQ RNA-directed DNA polymerase GLW17_10635 ENOG4105C5Y PTS System GLW17_10640 ENOG4105CS2 ec 3.2.1.21 GLW17_10660 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GLW17_10675 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GLW17_10680 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase GLW17_10700 ENOG41065S2 pneumococcal vaccine antigen GLW17_10710 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GLW17_10715 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GLW17_10730 ENOG4105QNR S1 RNA binding domain protein GLW17_10735 ENOG4105I3K Ferric uptake regulator, Fur family GLW17_10740 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GLW17_10745 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GLW17_10750 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GLW17_10755 ENOG4105FE9 pseudouridine synthase GLW17_10760 ENOG4108SAX Membrane GLW17_10775 ENOG4105C9U ATP-dependent DNA helicase RecQ GLW17_10785 ENOG4105CAT Cytidine monophosphate kinase GLW17_10795 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GLW17_10800 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GLW17_10805 ENOG4105K70 DNA-binding protein GLW17_10815 ENOG41068YB TPR repeat-containing protein GLW17_10820 ENOG4108SXZ UPF0302 protein GLW17_10825 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GLW17_10830 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GLW17_10855 ENOG4105WDJ 50S ribosomal protein L33 GLW17_10860 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GLW17_10875 ENOG4105DKQ ROK family GLW17_10880 ENOG4105WZW rhodanese family GLW17_10905 ENOG4105CMR udp-glucose 4-epimerase GLW17_10910 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase GLW17_10915 ENOG4105CQ4 Transcriptional regulator GLW17_10920 ENOG4108UW5 maltose o-acetyltransferase GLW17_10950 ENOG41072GX Peptidase M22 Glycoprotease GLW17_10965 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GLW17_10970 ENOG4105CE9 30S ribosomal protein S2 GLW17_10975 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GLW17_10980 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GLW17_10985 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GLW17_10990 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GLW17_10995 ENOG4105KNE Phosphatidate cytidylyltransferase GLW17_11000 ENOG4105DZP Membrane-associated zinc metalloprotease GLW17_11005 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GLW17_11010 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GLW17_11015 ENOG410902V Modulates RecA activity (By similarity) GLW17_11025 ENOG4105EVI UPF0374 protein GLW17_11040 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GLW17_11050 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GLW17_11060 ENOG4105KRI phosphocarrier protein (HPr GLW17_11065 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GLW17_11070 ENOG4108IGT Dipeptidase GLW17_11075 ENOG4105W2C Glycosyl transferase GLW17_11080 ENOG4105BZF Glycosyl transferase (Group 1 GLW17_11085 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GLW17_11090 ENOG4107IN1 Protein of unknown function (DUF1797) GLW17_11095 ENOG4105ZMH deoxynucleoside kinase GLW17_11110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GLW17_11115 ENOG410854A Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GLW17_11120 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GLW17_11125 ENOG4105CHR reductase GLW17_11130 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GLW17_11135 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GLW17_11140 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GLW17_11145 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GLW17_11150 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GLW17_11155 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GLW17_11165 ENOG4108S4H thioesterase Superfamily protein GLW17_11185 ENOG4108IUX (ABC) transporter GLW17_11190 ENOG4105RHA ABC transporter, permease GLW17_11195 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GLW17_11200 ENOG4105DUM transcriptional regulator, lysR family GLW17_11205 ENOG4105HMI Membrane GLW17_11210 ENOG4105E89 ABC transporter GLW17_11245 ENOG41067VN Glutaredoxin GLW17_11250 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GLW17_11265 ENOG4105C5I Dehydrogenase GLW17_11285 ENOG4105CPQ Dehydrogenase GLW17_11290 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GLW17_11295 ENOG4105EMD TRANSCRIPTIONal GLW17_11305 ENOG4105EMD TRANSCRIPTIONal GLW17_11310 ENOG4105CS2 ec 3.2.1.21 GLW17_11315 ENOG4105VZJ PTS System GLW17_11320 ENOG4105VCP PTS System GLW17_11330 ENOG4105CK1 PTS System GLW17_11345 ENOG4105G7B Protein of unknown function (DUF2992) GLW17_11390 ENOG4108RS6 transposase GLW17_11395 ENOG4105CSM endonuclease III GLW17_11405 ENOG4108JPW Aminotransferase GLW17_11415 ENOG4105BZ8 glutamate synthase GLW17_11430 ENOG4106P55 Transcriptional regulator GLW17_11455 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GLW17_11465 ENOG4105VUF Transcriptional regulator GLW17_11470 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GLW17_11475 ENOG4107R55 ethanolamine transporter GLW17_11485 ENOG4105CIS alcohol dehydrogenase GLW17_11490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GLW17_11495 ENOG4105BZU Histidine kinase GLW17_11510 ENOG4105Q2H domain protein GLW17_11520 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GLW17_11525 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GLW17_11535 ENOG4108TZY GntR Family Transcriptional Regulator GLW17_11540 ENOG4105CK1 PTS System GLW17_11545 ENOG4105CS2 ec 3.2.1.21 GLW17_11550 ENOG4105EKQ RNA-directed DNA polymerase GLW17_11555 ENOG4105DAP Nicotinate phosphoribosyltransferase GLW17_11560 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GLW17_11565 ENOG4107T7U Sulfatase GLW17_11570 ENOG4105DUM transcriptional regulator, lysR family GLW17_11575 ENOG4105MTF NrdI protein GLW17_11590 ENOG410667J hydrolase GLW17_11595 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GLW17_11600 ENOG4108IJ2 phosphate acetyltransferase GLW17_11605 ENOG4105K8N protein family UPF0079, ATPase GLW17_11615 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GLW17_11625 ENOG4105D4A Cell wall formation (By similarity) GLW17_11630 ENOG4107QQ0 gntp family GLW17_11635 ENOG4105BZW Glycerate kinase GLW17_11645 ENOG4105CK1 PTS System GLW17_11650 ENOG4105ETE Transcriptional regulator (LacI family GLW17_11660 ENOG4105CS2 ec 3.2.1.21 GLW17_11685 ENOG4106ETB IIa component GLW17_11690 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GLW17_11705 ENOG4105CV1 Transketolase (EC 2.2.1.1) GLW17_11750 ENOG4105DM4 PTS System GLW17_11755 ENOG4108YRF PTS System GLW17_11760 ENOG4105DM4 PTS System GLW17_11765 ENOG4105DM4 PTS System GLW17_11795 ENOG4105PAD Hydrolase GLW17_11805 ENOG4107RSM transcriptional regulator GLW17_11820 ENOG4108JJB ABC transporter GLW17_11840 ENOG4105CK1 PTS System GLW17_11845 ENOG4105CQB FAD linked oxidase domain protein GLW17_11875 ENOG4105ETE Transcriptional regulator (LacI family GLW17_11880 ENOG4105ETE Transcriptional regulator (LacI family