locus-tag	class	description
HFZ77_00015	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HFZ77_00025	COG1677	Flagellar hook-basal body complex protein FliE
HFZ77_00040	COG2198	Histidine kinase
HFZ77_00040	COG0643	Histidine kinase
HFZ77_00060	COG0840	transmembrane signaling receptor activity
HFZ77_00065	COG2201	protein-glutamate methylesterase activity
HFZ77_00070	COG0643	Histidine kinase
HFZ77_00070	COG2198	Histidine kinase
HFZ77_00130	COG1558	bacterial-type flagellum-dependent cell motility
HFZ77_00135	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HFZ77_00145	COG4786	Flagellar basal body rod
HFZ77_00170	COG1256	bacterial-type flagellum assembly
HFZ77_00190	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HFZ77_00235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HFZ77_00240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFZ77_00260	COG0629	single-stranded DNA binding
HFZ77_00280	COG0741	lytic transglycosylase activity
HFZ77_00285	COG1858	cytochrome C peroxidase
HFZ77_00295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HFZ77_00305	COG0233	cytoplasmic translational termination
HFZ77_00310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HFZ77_00320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HFZ77_00325	COG0750	zinc metalloprotease
HFZ77_00340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HFZ77_00345	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFZ77_00350	COG3494	Protein of unknown function (DUF1009)
HFZ77_00355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFZ77_00370	COG1612	heme a metabolic process
HFZ77_00375	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HFZ77_00390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HFZ77_00400	COG2095	MarC family integral membrane protein
HFZ77_00405	COG0488	(ABC) transporter
HFZ77_00415	COG0105	UTP biosynthetic process
HFZ77_00430	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_00450	COG3750	Belongs to the UPF0335 family
HFZ77_00485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HFZ77_00535	COG4626	Terminase
HFZ77_00535	COG1802	Transcriptional regulator
HFZ77_00545	COG0616	signal peptide processing
HFZ77_00670	COG0840	transmembrane signaling receptor activity
HFZ77_00675	COG3246	L-lysine catabolic process to acetate
HFZ77_00685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFZ77_00710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFZ77_00715	COG2151	metal-sulfur cluster biosynthetic enzyme
HFZ77_00720	COG3396	Phenylacetate-CoA oxygenase
HFZ77_00725	COG3460	Phenylacetate-CoA oxygenase
HFZ77_00730	COG3396	Phenylacetate-CoA oxygenase
HFZ77_00735	COG0840	transmembrane signaling receptor activity
HFZ77_00740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HFZ77_00745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFZ77_00750	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HFZ77_00760	COG2166	iron-sulfur cluster assembly
HFZ77_00770	COG5012	cobalamin binding
HFZ77_00780	COG1410	methionine synthase
HFZ77_00780	COG0646	methionine synthase
HFZ77_00790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HFZ77_00795	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFZ77_00800	COG0047	phosphoribosylformylglycinamidine synthase activity
HFZ77_00810	COG2204	response regulator
HFZ77_00815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFZ77_00820	COG1530	ribonuclease E activity
HFZ77_00825	COG0785	Cytochrome C biogenesis protein
HFZ77_00850	COG0114	fumarate hydratase activity
HFZ77_00875	COG2186	Transcriptional regulator
HFZ77_00880	COG0604	alcohol dehydrogenase
HFZ77_00885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFZ77_00890	COG0415	Belongs to the DNA photolyase family
HFZ77_00895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HFZ77_00905	COG0494	nUDIX hydrolase
HFZ77_00915	COG3264	Mechanosensitive ion channel
HFZ77_00915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HFZ77_00920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFZ77_00965	COG0513	Belongs to the DEAD box helicase family
HFZ77_00970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFZ77_01005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HFZ77_01035	COG0405	Gamma-glutamyltransferase
HFZ77_01040	COG1741	Belongs to the pirin family
HFZ77_01050	COG0145	ligase activity
HFZ77_01090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFZ77_01135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFZ77_01145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HFZ77_01170	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFZ77_01180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ77_01190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HFZ77_01200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HFZ77_01205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HFZ77_01215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFZ77_01275	COG2197	response regulator
HFZ77_01285	COG0784	Response regulator, receiver
HFZ77_01285	COG2198	Histidine kinase
HFZ77_01285	COG2205	protein histidine kinase activity
HFZ77_01290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFZ77_01295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFZ77_01300	COG1121	(ABC) transporter
HFZ77_01315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFZ77_01320	COG0730	response to heat
HFZ77_01335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HFZ77_01340	COG4235	cytochrome complex assembly
HFZ77_01345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ77_01355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HFZ77_01355	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFZ77_01375	COG2205	protein histidine kinase activity
HFZ77_01375	COG0784	Response regulator, receiver
HFZ77_01385	COG1611	Belongs to the LOG family
HFZ77_01400	COG5265	(ABC) transporter
HFZ77_01425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFZ77_01440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFZ77_01445	COG1160	GTP binding
HFZ77_01450	COG3239	Fatty acid desaturase
HFZ77_01455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HFZ77_01460	COG1862	Preprotein translocase
HFZ77_01465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFZ77_01470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFZ77_01480	COG3737	Protein of unknown function (DUF498/DUF598)
HFZ77_01485	COG4133	protoheme IX ABC transporter activity
HFZ77_01490	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFZ77_01495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFZ77_01505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ77_01510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFZ77_01515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HFZ77_01525	COG1560	Kdo2-lipid A biosynthetic process
HFZ77_01535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HFZ77_01560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ77_01575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ77_01590	COG5002	protein histidine kinase activity
HFZ77_01590	COG2176	DNA-directed DNA polymerase activity
HFZ77_01595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HFZ77_01610	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HFZ77_01615	COG0646	methionine synthase
HFZ77_01615	COG1410	methionine synthase
HFZ77_01620	COG4566	intracellular signal transduction
HFZ77_01640	COG2020	methyltransferase activity
HFZ77_01665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HFZ77_01665	COG3743	rRNA binding
HFZ77_01670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HFZ77_01680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HFZ77_01685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HFZ77_01690	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HFZ77_01715	COG0482	sulfurtransferase activity
HFZ77_01730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HFZ77_01735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFZ77_01745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HFZ77_01750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFZ77_01755	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HFZ77_01760	COG1858	cytochrome C peroxidase
HFZ77_01765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HFZ77_01775	COG2755	lipolytic protein G-D-S-L family
HFZ77_01775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HFZ77_01785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ77_01790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HFZ77_01805	COG1309	transcriptional regulator
HFZ77_01810	COG2326	polyphosphate kinase activity
HFZ77_01815	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HFZ77_01830	COG0697	spore germination
HFZ77_01835	COG0519	Catalyzes the synthesis of GMP from XMP
HFZ77_01835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFZ77_01875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFZ77_01880	COG2010	Cytochrome c
HFZ77_01885	COG3909	cytochrome
HFZ77_01900	COG2867	negative regulation of translational initiation
HFZ77_01905	COG0004	ammonium transporteR
HFZ77_01910	COG1058	Belongs to the CinA family
HFZ77_01910	COG1546	Belongs to the CinA family
HFZ77_01920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HFZ77_01920	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HFZ77_01925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFZ77_01930	COG3852	Histidine kinase
HFZ77_01935	COG2204	response regulator
HFZ77_01940	COG5000	phosphorelay sensor kinase activity
HFZ77_01945	COG2204	response regulator
HFZ77_01965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HFZ77_02000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HFZ77_02025	COG2354	Protein conserved in bacteria
HFZ77_02035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFZ77_02060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HFZ77_02070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFZ77_02075	COG0583	DNA-binding transcription factor activity
HFZ77_02090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HFZ77_02095	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HFZ77_02110	COG1138	Cytochrome C-type biogenesis protein
HFZ77_02115	COG3088	subunit of a heme lyase
HFZ77_02120	COG1024	Enoyl-CoA hydratase
HFZ77_02125	COG0372	Belongs to the citrate synthase family
HFZ77_02130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFZ77_02135	COG0658	competence protein
HFZ77_02135	COG2333	competence protein COMEC
HFZ77_02140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFZ77_02145	COG0303	'Molybdopterin
HFZ77_02150	COG0315	cyclic pyranopterin monophosphate synthase activity
HFZ77_02160	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HFZ77_02165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFZ77_02180	COG1187	pseudouridine synthase activity
HFZ77_02185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFZ77_02205	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HFZ77_02210	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HFZ77_02215	COG0259	pyridoxamine-phosphate oxidase activity
HFZ77_02235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFZ77_02250	COG1238	metal cluster binding
HFZ77_02275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HFZ77_02280	COG4536	flavin adenine dinucleotide binding
HFZ77_02285	COG4974	Belongs to the 'phage' integrase family
HFZ77_02300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HFZ77_02305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HFZ77_02315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HFZ77_02320	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HFZ77_02330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HFZ77_02335	COG0363	glucosamine-6-phosphate deaminase activity
HFZ77_02340	COG0166	Belongs to the GPI family
HFZ77_02360	COG0697	spore germination
HFZ77_02370	COG0384	phenazine biosynthesis protein PhzF
HFZ77_02395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HFZ77_02410	COG2207	Transcriptional regulator
HFZ77_02410	COG3708	Transcriptional regulator
HFZ77_02420	COG1840	ABC-type Fe3 transport system, periplasmic component
HFZ77_02425	COG3956	TIGRFAM MazG family protein
HFZ77_02430	COG1473	amidohydrolase
HFZ77_02435	COG0010	Belongs to the arginase family
HFZ77_02450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HFZ77_02455	COG2890	protein-(glutamine-N5) methyltransferase activity
HFZ77_02465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HFZ77_02470	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HFZ77_02480	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HFZ77_02490	COG0795	lipopolysaccharide-transporting ATPase activity
HFZ77_02495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HFZ77_02520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HFZ77_02535	COG2945	thiolester hydrolase activity
HFZ77_02550	COG0719	Fe-S assembly protein
HFZ77_02565	COG0393	Putative heavy-metal-binding
HFZ77_02575	COG0396	ATPase activity
HFZ77_02580	COG0719	Fe-S assembly protein
HFZ77_02595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFZ77_02625	COG3108	Peptidase M15
HFZ77_02635	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFZ77_02640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFZ77_02655	COG0433	COG0433 Predicted ATPase
HFZ77_02690	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HFZ77_02700	COG1561	YicC-like family, N-terminal region
HFZ77_02705	COG0194	GDP metabolic process
HFZ77_02715	COG5002	protein histidine kinase activity
HFZ77_02725	COG0573	inorganic phosphate transmembrane transporter activity
HFZ77_02735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFZ77_02745	COG0745	RESPONSE REGULATOR receiver
HFZ77_02750	COG0583	DNA-binding transcription factor activity
HFZ77_02755	COG1960	acyl-CoA dehydrogenase activity
HFZ77_02760	COG4585	Histidine kinase
HFZ77_02775	COG2197	response regulator
HFZ77_02780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HFZ77_02785	COG0052	Belongs to the universal ribosomal protein uS2 family
HFZ77_02795	COG2313	pseudouridylate synthase activity
HFZ77_02810	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_02815	COG4166	transmembrane transport
HFZ77_02835	COG2814	Major facilitator Superfamily
HFZ77_02840	COG0538	isocitrate dehydrogenase activity
HFZ77_02850	COG2084	Dehydrogenase
HFZ77_02860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFZ77_02865	COG1923	regulation of RNA biosynthetic process
HFZ77_02870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFZ77_02875	COG0569	domain protein
HFZ77_02885	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFZ77_02890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HFZ77_02900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFZ77_02915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HFZ77_02925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFZ77_02930	COG2833	Protein of unknown function (DUF455)
HFZ77_02935	COG0739	heme binding
HFZ77_02960	COG2099	Precorrin-6x reductase
HFZ77_02965	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HFZ77_02975	COG1797	cobyrinic acid a,c-diamide synthase activity
HFZ77_02980	COG2814	Major facilitator Superfamily
HFZ77_02995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFZ77_03000	COG0215	cysteine-tRNA ligase activity
HFZ77_03020	COG0126	phosphoglycerate kinase activity
HFZ77_03025	COG3588	fructose-bisphosphate aldolase
HFZ77_03030	COG3214	Protein conserved in bacteria
HFZ77_03040	COG1960	acyl-CoA dehydrogenase activity
HFZ77_03050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HFZ77_03055	COG0022	dehydrogenase e1 component
HFZ77_03055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ77_03060	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ77_03070	COG0583	DNA-binding transcription factor activity
HFZ77_03155	COG4695	Portal protein
HFZ77_03170	COG0019	diaminopimelate decarboxylase activity
HFZ77_03185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HFZ77_03190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ77_03195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFZ77_03205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HFZ77_03210	COG3038	cytochrome b561
HFZ77_03215	COG2353	YceI-like domain
HFZ77_03225	COG0360	Binds together with S18 to 16S ribosomal RNA
HFZ77_03230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HFZ77_03235	COG0359	binds to the 23S rRNA
HFZ77_03245	COG3916	Acyl-homoserine-lactone synthase
HFZ77_03255	COG0544	peptidyl-prolyl cis-trans isomerase activity
HFZ77_03270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFZ77_03315	COG1653	transport
HFZ77_03325	COG0395	ABC-type sugar transport system, permease component
HFZ77_03330	COG3842	ATPase activity
HFZ77_03335	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_03365	COG2267	carboxylic ester hydrolase activity
HFZ77_03375	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_03520	COG2197	response regulator
HFZ77_03580	COG0010	Belongs to the arginase family
HFZ77_03600	COG1960	acyl-CoA dehydrogenase activity
HFZ77_03605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ77_03615	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_03625	COG2188	Transcriptional regulator
HFZ77_03675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HFZ77_03680	COG0416	fatty acid biosynthetic process
HFZ77_03685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFZ77_03690	COG0776	regulation of translation
HFZ77_03705	COG1024	Enoyl-CoA hydratase
HFZ77_03710	COG0717	Belongs to the dCTP deaminase family
HFZ77_03730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HFZ77_03740	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ77_03750	COG0018	arginyl-trna synthetase
HFZ77_03760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HFZ77_03765	COG0316	Belongs to the HesB IscA family
HFZ77_03790	COG0542	response to heat
HFZ77_03820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HFZ77_03830	COG0129	dihydroxy-acid dehydratase activity
HFZ77_03835	COG0800	Aldolase
HFZ77_03865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HFZ77_03870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HFZ77_03895	COG0028	Belongs to the TPP enzyme family
HFZ77_03900	COG0440	acetolactate synthase activity
HFZ77_03925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HFZ77_03930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HFZ77_03935	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFZ77_03940	COG0436	Aminotransferase
HFZ77_03945	COG0501	Belongs to the peptidase M48B family
HFZ77_03960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HFZ77_03970	COG0156	8-amino-7-oxononanoate synthase activity
HFZ77_04015	COG1215	transferase activity, transferring glycosyl groups
HFZ77_04030	COG2135	peptidase activity
HFZ77_04045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HFZ77_04060	COG0343	queuine tRNA-ribosyltransferase activity
HFZ77_04075	COG0189	ligase activity
HFZ77_04075	COG4067	protein conserved in archaea
HFZ77_04085	COG2151	metal-sulfur cluster biosynthetic enzyme
HFZ77_04100	COG0316	Belongs to the HesB IscA family
HFZ77_04105	COG0149	triose-phosphate isomerase activity
HFZ77_04110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HFZ77_04115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HFZ77_04120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFZ77_04130	COG4191	Histidine kinase
HFZ77_04135	COG1522	sequence-specific DNA binding
HFZ77_04145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFZ77_04150	COG0175	sulfate reduction
HFZ77_04170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HFZ77_04175	COG4106	trans-aconitate 2-methyltransferase activity
HFZ77_04225	COG0131	Imidazoleglycerol-phosphate dehydratase
HFZ77_04230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HFZ77_04245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HFZ77_04250	COG0107	imidazoleglycerol-phosphate synthase activity
HFZ77_04255	COG0140	phosphoribosyl-ATP diphosphatase activity
HFZ77_04265	COG0411	ABC transporter
HFZ77_04295	COG1846	Transcriptional regulator
HFZ77_04330	COG1832	CoA-binding protein
HFZ77_04340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFZ77_04365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HFZ77_04620	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_04635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFZ77_04640	COG1917	Cupin 2, conserved barrel domain protein
HFZ77_04645	COG0527	aspartate kinase activity
HFZ77_04650	COG3842	ATPase activity
HFZ77_04655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFZ77_04660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFZ77_04665	COG0805	protein transport
HFZ77_04680	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HFZ77_04705	COG0713	ATP synthesis coupled electron transport
HFZ77_04725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFZ77_04735	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HFZ77_04775	COG0649	NAD binding
HFZ77_04780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFZ77_04785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFZ77_04795	COG1024	Enoyl-CoA hydratase
HFZ77_04795	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ77_04810	COG4770	biotin carboxylase activity
HFZ77_04820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ77_04825	COG1960	acyl-CoA dehydrogenase activity
HFZ77_04840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HFZ77_04860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HFZ77_04865	COG1519	Transferase
HFZ77_04875	COG1473	amidohydrolase
HFZ77_04880	COG1473	amidohydrolase
HFZ77_04890	COG4172	Belongs to the ABC transporter superfamily
HFZ77_04900	COG0601	transmembrane transport
HFZ77_04905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFZ77_04920	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HFZ77_04940	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_04955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HFZ77_04965	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HFZ77_04970	COG2155	Conserved Protein
HFZ77_04975	COG0308	aminopeptidase N
HFZ77_04985	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_04995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFZ77_05010	COG0484	heat shock protein binding
HFZ77_05020	COG3750	Belongs to the UPF0335 family
HFZ77_05050	COG2391	methyltransferase activity
HFZ77_05075	COG0745	RESPONSE REGULATOR receiver
HFZ77_05080	COG1396	sequence-specific DNA binding
HFZ77_05080	COG3800	Transcriptional regulator
HFZ77_05105	COG0410	ABC transporter
HFZ77_05110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ77_05125	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_05135	COG0183	Belongs to the thiolase family
HFZ77_05145	COG0511	ligase activity, forming carbon-carbon bonds
HFZ77_05150	COG0439	Biotin carboxylase
HFZ77_05155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HFZ77_05185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HFZ77_05190	COG0740	serine-type endopeptidase activity
HFZ77_05210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HFZ77_05215	COG0737	Belongs to the 5'-nucleotidase family
HFZ77_05220	COG3258	Cytochrome c
HFZ77_05245	COG0785	Cytochrome C biogenesis protein
HFZ77_05260	COG2391	methyltransferase activity
HFZ77_05280	COG1136	(ABC) transporter
HFZ77_05280	COG0577	efflux transmembrane transporter activity
HFZ77_05315	COG0277	FAD linked oxidase domain protein
HFZ77_05325	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFZ77_05330	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HFZ77_05335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFZ77_05340	COG0849	cell division
HFZ77_05345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HFZ77_05350	COG1181	Belongs to the D-alanine--D-alanine ligase family
HFZ77_05355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HFZ77_05370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFZ77_05375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HFZ77_05385	COG2081	HI0933 family
HFZ77_05390	COG1610	YqeY-like protein
HFZ77_05395	COG0505	Belongs to the CarA family
HFZ77_05405	COG1802	Transcriptional regulator
HFZ77_05420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFZ77_05425	COG0840	transmembrane signaling receptor activity
HFZ77_05445	COG1522	sequence-specific DNA binding
HFZ77_05455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HFZ77_05460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFZ77_05465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HFZ77_05470	COG3773	Cell wall hydrolase
HFZ77_05470	COG3409	Peptidoglycan-binding domain 1 protein
HFZ77_05475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFZ77_05475	COG0574	Belongs to the PEP-utilizing enzyme family
HFZ77_05480	COG0751	glycine-tRNA ligase activity
HFZ77_05490	COG0752	glycyl-tRNA synthetase alpha subunit
HFZ77_05500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFZ77_05515	COG1469	GTP cyclohydrolase I activity
HFZ77_05525	COG0625	glutathione transferase activity
HFZ77_05530	COG2917	probably involved in intracellular septation
HFZ77_05545	COG0552	protein localization to endoplasmic reticulum
HFZ77_05565	COG1570	exodeoxyribonuclease VII activity
HFZ77_05570	COG0151	Belongs to the GarS family
HFZ77_05595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFZ77_05605	COG0330	HflC and HflK could
HFZ77_05610	COG0330	HflC and HflK could
HFZ77_05620	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HFZ77_05630	COG1760	l-serine dehydratase
HFZ77_05650	COG3706	GGDEF domain
HFZ77_05675	COG3706	GGDEF domain
HFZ77_05715	COG0667	Aldo Keto reductase
HFZ77_05725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFZ77_05730	COG0028	Belongs to the TPP enzyme family
HFZ77_05735	COG2824	Alkylphosphonate utilization operon protein PhnA
HFZ77_05740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFZ77_05745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HFZ77_05755	COG2308	Evidence 4 Homologs of previously reported genes of
HFZ77_05775	COG1321	iron dependent repressor
HFZ77_05780	COG1914	H( )-stimulated, divalent metal cation uptake system
HFZ77_05795	COG1522	sequence-specific DNA binding
HFZ77_05805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HFZ77_05840	COG0582	viral genome integration into host DNA
HFZ77_05930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ77_05940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HFZ77_05945	COG0459	protein refolding
HFZ77_05965	COG3457	Alanine racemase
HFZ77_06000	COG1228	amidohydrolase
HFZ77_06010	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HFZ77_06015	COG3639	organic phosphonate transmembrane transporter activity
HFZ77_06030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFZ77_06035	COG1127	ABC transporter
HFZ77_06070	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HFZ77_06075	COG1024	Enoyl-CoA hydratase
HFZ77_06080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ77_06100	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_06110	COG1116	anion transmembrane transporter activity
HFZ77_06130	COG0726	polysaccharide deacetylase
HFZ77_06135	COG3239	Fatty acid desaturase
HFZ77_06150	COG1278	Cold shock
HFZ77_06160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFZ77_06165	COG3622	Belongs to the hyi family
HFZ77_06170	COG2076	Multidrug Resistance protein
HFZ77_06175	COG0546	phosphoglycolate phosphatase activity
HFZ77_06175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HFZ77_06190	COG0456	acetyltransferase
HFZ77_06205	COG1216	Glycosyl transferase, family 2
HFZ77_06220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ77_06230	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HFZ77_06235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFZ77_06265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFZ77_06265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFZ77_06270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HFZ77_06285	COG0840	transmembrane signaling receptor activity
HFZ77_06295	COG0432	Pfam Uncharacterised protein family UPF0047
HFZ77_06310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HFZ77_06315	COG0358	DNA primase activity
HFZ77_06345	COG1309	transcriptional regulator
HFZ77_06360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ77_06400	COG1490	D-aminoacyl-tRNA deacylase activity
HFZ77_06405	COG0071	Belongs to the small heat shock protein (HSP20) family
HFZ77_06455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFZ77_06460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFZ77_06465	COG0583	DNA-binding transcription factor activity
HFZ77_06470	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HFZ77_06485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HFZ77_06490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFZ77_06500	COG5328	Belongs to the UPF0262 family
HFZ77_06505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HFZ77_06515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HFZ77_06545	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_06550	COG1132	(ABC) transporter
HFZ77_06555	COG1522	sequence-specific DNA binding
HFZ77_06570	COG2207	Transcriptional regulator
HFZ77_06570	COG1917	Cupin 2, conserved barrel domain protein
HFZ77_06575	COG1335	isochorismatase
HFZ77_06580	COG0737	Belongs to the 5'-nucleotidase family
HFZ77_06605	COG0534	Mate efflux family protein
HFZ77_06630	COG1960	acyl-CoA dehydrogenase activity
HFZ77_06640	COG0625	glutathione transferase activity
HFZ77_06645	COG0183	Belongs to the thiolase family
HFZ77_06650	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ77_06650	COG1024	Enoyl-CoA hydratase
HFZ77_06665	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_06685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HFZ77_06690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HFZ77_06695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HFZ77_06700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HFZ77_06710	COG0281	malic enzyme
HFZ77_06710	COG0280	phosphate acetyltransferase
HFZ77_06735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HFZ77_06740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HFZ77_06750	COG0596	Alpha beta hydrolase
HFZ77_06770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HFZ77_06810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ77_06820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFZ77_06850	COG1136	(ABC) transporter
HFZ77_06865	COG0442	prolyl-tRNA aminoacylation
HFZ77_06875	COG0628	permease
HFZ77_06885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HFZ77_06890	COG0248	Ppx GppA phosphatase
HFZ77_06905	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HFZ77_06915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFZ77_06920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ77_06920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ77_06930	COG4770	biotin carboxylase activity
HFZ77_06960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFZ77_06965	COG2814	Major facilitator Superfamily
HFZ77_06970	COG3800	Transcriptional regulator
HFZ77_06970	COG1396	sequence-specific DNA binding
HFZ77_06980	COG3618	amidohydrolase
HFZ77_06995	COG3119	arylsulfatase activity
HFZ77_07015	COG4175	Glycine betaine
HFZ77_07015	COG3448	diguanylate cyclase activity
HFZ77_07035	COG0583	DNA-binding transcription factor activity
HFZ77_07040	COG0217	transcriptional regulatory protein
HFZ77_07045	COG0471	metal ion transport
HFZ77_07045	COG3273	potassium ion transport
HFZ77_07050	COG1692	metallophosphoesterase
HFZ77_07055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ77_07065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFZ77_07070	COG2239	Acts as a magnesium transporter
HFZ77_07075	COG0402	S-adenosylhomocysteine deaminase activity
HFZ77_07090	COG0483	inositol monophosphate 1-phosphatase activity
HFZ77_07095	COG1396	sequence-specific DNA binding
HFZ77_07100	COG1063	alcohol dehydrogenase
HFZ77_07105	COG0583	DNA-binding transcription factor activity
HFZ77_07115	COG0670	Belongs to the BI1 family
HFZ77_07130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ77_07140	COG3023	N-Acetylmuramoyl-L-alanine amidase
HFZ77_07150	COG0154	amidase activity
HFZ77_07155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFZ77_07185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HFZ77_07195	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFZ77_07200	COG0590	tRNA wobble adenosine to inosine editing
HFZ77_07205	COG1187	pseudouridine synthase activity
HFZ77_07215	COG3853	Toxic anion resistance protein (TelA)
HFZ77_07240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HFZ77_07270	COG0454	-acetyltransferase
HFZ77_07270	COG0456	acetyltransferase
HFZ77_07280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HFZ77_07290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HFZ77_07305	COG0612	Peptidase, M16
HFZ77_07320	COG0277	FAD linked oxidase domain protein
HFZ77_07330	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HFZ77_07340	COG0109	protoheme IX farnesyltransferase activity
HFZ77_07350	COG0312	modulator of DNA gyrase
HFZ77_07355	COG0758	DNA mediated transformation
HFZ77_07365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HFZ77_07365	COG1754	DNA topoisomerase type I activity
HFZ77_07365	COG1754	DNA topoisomerase type I activity
HFZ77_07365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HFZ77_07420	COG4964	Belongs to the GSP D family
HFZ77_07490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HFZ77_07495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HFZ77_07510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFZ77_07515	COG0037	tRNA processing
HFZ77_07525	COG2885	chlorophyll binding
HFZ77_07530	COG0823	Involved in the tonB-independent uptake of proteins
HFZ77_07550	COG0824	Thioesterase
HFZ77_07565	COG2255	four-way junction helicase activity
HFZ77_07570	COG0632	four-way junction helicase activity
HFZ77_07575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HFZ77_07590	COG2264	protein methyltransferase activity
HFZ77_07605	COG0431	NADPH-dependent FMN reductase
HFZ77_07610	COG0483	inositol monophosphate 1-phosphatase activity
HFZ77_07615	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFZ77_07615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFZ77_07620	COG0509	glycine decarboxylation via glycine cleavage system
HFZ77_07625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HFZ77_07630	COG1959	2 iron, 2 sulfur cluster binding
HFZ77_07645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFZ77_07650	COG1234	tRNA 3'-trailer cleavage
HFZ77_07685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFZ77_07695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFZ77_07705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ77_07710	COG1012	belongs to the aldehyde dehydrogenase family
HFZ77_07715	COG1522	sequence-specific DNA binding
HFZ77_07740	COG0659	secondary active sulfate transmembrane transporter activity
HFZ77_07755	COG4948	Mandelate Racemase Muconate Lactonizing
HFZ77_07760	COG0640	Transcriptional regulator
HFZ77_07775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFZ77_07780	COG0725	ABC transporter, periplasmic molybdate-binding protein
HFZ77_07785	COG4149	molybdate abc transporter
HFZ77_07790	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HFZ77_07800	COG0300	oxidoreductase activity
HFZ77_07800	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_07800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFZ77_07800	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_07800	COG3321	synthase
HFZ77_07810	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_07820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HFZ77_07840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HFZ77_07865	COG1850	ribulose-bisphosphate carboxylase activity
HFZ77_07890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ77_07900	COG0089	rRNA binding
HFZ77_07905	COG0088	Forms part of the polypeptide exit tunnel
HFZ77_07910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HFZ77_07915	COG0051	transcription antitermination factor activity, RNA binding
HFZ77_07920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HFZ77_07925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HFZ77_07930	COG0049	tRNA binding
HFZ77_07935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HFZ77_07950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HFZ77_07955	COG0085	RNA polymerase activity
HFZ77_07960	COG0222	ribosome binding
HFZ77_07965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HFZ77_07970	COG0081	regulation of translation
HFZ77_07975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HFZ77_07980	COG0250	Participates in transcription elongation, termination and antitermination
HFZ77_08005	COG0072	phenylalanine-tRNA ligase activity
HFZ77_08005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFZ77_08015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HFZ77_08020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HFZ77_08025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HFZ77_08035	COG0469	pyruvate kinase activity
HFZ77_08055	COG1047	Peptidyl-prolyl cis-trans
HFZ77_08080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFZ77_08090	COG0006	proline dipeptidase activity
HFZ77_08115	COG1902	pentaerythritol trinitrate reductase activity
HFZ77_08120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ77_08135	COG0235	Class ii aldolase
HFZ77_08155	COG4172	Belongs to the ABC transporter superfamily
HFZ77_08160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFZ77_08170	COG0154	amidase activity
HFZ77_08195	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_08210	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ77_08215	COG0778	Nitroreductase
HFZ77_08240	COG1802	Transcriptional regulator
HFZ77_08250	COG0556	nucleotide-excision repair
HFZ77_08280	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HFZ77_08285	COG1214	PFAM Peptidase M22, glycoprotease
HFZ77_08295	COG0730	response to heat
HFZ77_08305	COG0300	oxidoreductase activity
HFZ77_08320	COG0604	alcohol dehydrogenase
HFZ77_08325	COG2937	Belongs to the GPAT DAPAT family
HFZ77_08330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ77_08330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ77_08335	COG1254	Belongs to the acylphosphatase family
HFZ77_08345	COG0813	purine-nucleoside phosphorylase activity
HFZ77_08400	COG2030	dehydratase
HFZ77_08425	COG0039	L-malate dehydrogenase activity
HFZ77_08440	COG0045	succinate-CoA ligase (ADP-forming) activity
HFZ77_08445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HFZ77_08455	COG0567	Dehydrogenase, E1 component
HFZ77_08460	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ77_08500	COG2884	Cell division ATP-binding protein ftsE
HFZ77_08510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HFZ77_08535	COG0772	Belongs to the SEDS family
HFZ77_08540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFZ77_08550	COG1573	uracil-dna glycosylase
HFZ77_08555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFZ77_08565	COG3524	carbohydrate:proton symporter activity
HFZ77_08580	COG0339	signal peptide processing
HFZ77_08625	COG0606	chelatase, subunit chli
HFZ77_08630	COG0189	ligase activity
HFZ77_08635	COG0792	nuclease activity
HFZ77_08640	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HFZ77_08650	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HFZ77_08665	COG0180	Tryptophanyl-tRNA synthetase
HFZ77_08680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFZ77_08700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HFZ77_08705	COG1132	(ABC) transporter
HFZ77_08710	COG1703	isobutyryl-CoA mutase activity
HFZ77_08715	COG1643	Atp-dependent helicase
HFZ77_08725	COG0306	phosphate transporter
HFZ77_08735	COG0842	Transport permease protein
HFZ77_08740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFZ77_08760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HFZ77_08800	COG1872	DUF167
HFZ77_08840	COG1802	Transcriptional regulator
HFZ77_08865	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_08870	COG0322	excinuclease ABC activity
HFZ77_08885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HFZ77_08895	COG0314	molybdopterin synthase activity
HFZ77_08925	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ77_08930	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HFZ77_08940	COG2151	metal-sulfur cluster biosynthetic enzyme
HFZ77_08940	COG0489	protein tyrosine kinase activity
HFZ77_08950	COG0745	RESPONSE REGULATOR receiver
HFZ77_08955	COG0346	lactoylglutathione lyase activity
HFZ77_08970	COG0778	Nitroreductase
HFZ77_08975	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HFZ77_08980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ77_09015	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HFZ77_09020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HFZ77_09045	COG0284	orotidine-5'-phosphate decarboxylase activity
HFZ77_09050	COG0494	nUDIX hydrolase
HFZ77_09055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFZ77_09070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HFZ77_09080	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ77_09090	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HFZ77_09115	COG0559	Belongs to the binding-protein-dependent transport system permease family
HFZ77_09125	COG1022	Amp-dependent synthetase and ligase
HFZ77_09155	COG4095	Psort location CytoplasmicMembrane, score
HFZ77_09190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HFZ77_09195	COG0116	Belongs to the methyltransferase superfamily
HFZ77_09210	COG5002	protein histidine kinase activity
HFZ77_09210	COG2205	protein histidine kinase activity
HFZ77_09210	COG0784	Response regulator, receiver
HFZ77_09215	COG1129	ABC transporter
HFZ77_09220	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ77_09245	COG0835	chemotaxis
HFZ77_09250	COG0643	Histidine kinase
HFZ77_09250	COG2198	Histidine kinase
HFZ77_09285	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ77_09290	COG0559	Belongs to the binding-protein-dependent transport system permease family
HFZ77_09300	COG0829	nickel cation binding
HFZ77_09305	COG0831	urea catabolic process
HFZ77_09310	COG0832	Belongs to the urease beta subunit family
HFZ77_09320	COG0804	urea catabolic process
HFZ77_09330	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HFZ77_09335	COG0830	nickel cation binding
HFZ77_09340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HFZ77_09350	COG2307	Protein conserved in bacteria
HFZ77_09350	COG2308	Evidence 4 Homologs of previously reported genes of
HFZ77_09355	COG1305	Transglutaminase-like
HFZ77_09360	COG1960	acyl-CoA dehydrogenase activity
HFZ77_09365	COG0583	DNA-binding transcription factor activity
HFZ77_09380	COG0625	glutathione transferase activity
HFZ77_09395	COG0583	DNA-binding transcription factor activity
HFZ77_09400	COG1902	pentaerythritol trinitrate reductase activity
HFZ77_09400	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFZ77_09410	COG0431	NADPH-dependent FMN reductase
HFZ77_09435	COG1266	CAAX protease self-immunity
HFZ77_09445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HFZ77_09450	COG0285	dihydrofolate synthase activity
HFZ77_09455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HFZ77_09470	COG2423	ornithine cyclodeaminase activity
HFZ77_09480	COG1671	Belongs to the UPF0178 family
HFZ77_09485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HFZ77_09490	COG0679	Auxin Efflux Carrier
HFZ77_09510	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HFZ77_09525	COG2050	protein possibly involved in aromatic compounds catabolism
HFZ77_09530	COG2030	dehydratase
HFZ77_09530	COG1012	belongs to the aldehyde dehydrogenase family
HFZ77_09540	COG0791	NLP P60 protein
HFZ77_09545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HFZ77_09560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HFZ77_09580	COG0154	amidase activity
HFZ77_09595	COG4638	Rieske (2fe-2S)
HFZ77_09615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ77_09620	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFZ77_09650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HFZ77_09655	COG3842	ATPase activity
HFZ77_09660	COG1176	ABC-type spermidine putrescine transport system, permease component I
HFZ77_09665	COG1177	transmembrane transport
HFZ77_09690	COG0288	reversible hydration of carbon dioxide
HFZ77_09700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HFZ77_09715	COG4177	L-phenylalanine transmembrane transporter activity
HFZ77_09740	COG1346	cytolysis
HFZ77_09780	COG0747	negative chemotaxis
HFZ77_09785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ77_09790	COG2771	luxR family
HFZ77_09800	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HFZ77_09805	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_09810	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_09820	COG3321	synthase
HFZ77_09820	COG0604	alcohol dehydrogenase
HFZ77_09820	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_09835	COG0411	ABC transporter
HFZ77_09850	COG0683	leucine binding
HFZ77_09855	COG1960	acyl-CoA dehydrogenase activity
HFZ77_09860	COG1960	acyl-CoA dehydrogenase activity
HFZ77_09875	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_09880	COG0183	Belongs to the thiolase family
HFZ77_09900	COG2130	NADP-dependent
HFZ77_09905	COG1960	acyl-CoA dehydrogenase activity
HFZ77_09910	COG1960	acyl-CoA dehydrogenase activity
HFZ77_09915	COG1024	Enoyl-CoA hydratase
HFZ77_09915	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ77_09920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HFZ77_09990	COG1058	Belongs to the CinA family
HFZ77_09990	COG1546	Belongs to the CinA family
HFZ77_09995	COG1489	DNA binding
HFZ77_10000	COG0024	Methionine aminopeptidase
HFZ77_10005	COG0842	Transport permease protein
HFZ77_10010	COG1129	ABC transporter
HFZ77_10010	COG0842	Transport permease protein
HFZ77_10015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFZ77_10025	COG0659	secondary active sulfate transmembrane transporter activity
HFZ77_10030	COG0589	response to stress
HFZ77_10035	COG0742	ribosomal rna small subunit methyltransferase
HFZ77_10045	COG0678	peroxiredoxin activity
HFZ77_10055	COG0668	transmembrane transport
HFZ77_10060	COG2154	pterin-4-alpha-carbinolamine dehydratase
HFZ77_10075	COG0251	oxidation-reduction process
HFZ77_10080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFZ77_10090	COG2853	Lipoprotein
HFZ77_10100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ77_10105	COG0347	Belongs to the P(II) protein family
HFZ77_10110	COG0004	ammonium transporteR
HFZ77_10115	COG2183	response to ionizing radiation
HFZ77_10120	COG1618	nucleotide phosphatase activity, acting on free nucleotides
HFZ77_10120	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HFZ77_10140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ77_10155	COG3591	Belongs to the peptidase S1B family
HFZ77_10160	COG3591	Belongs to the peptidase S1B family
HFZ77_10165	COG0247	lactate metabolic process
HFZ77_10170	COG0277	FAD linked oxidase domain protein
HFZ77_10175	COG0277	FAD linked oxidase domain protein
HFZ77_10210	COG0714	Associated with various cellular activities
HFZ77_10230	COG1946	Acyl-CoA thioesterase
HFZ77_10235	COG1230	cation diffusion facilitator family transporter
HFZ77_10240	COG1131	(ABC) transporter
HFZ77_10250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFZ77_10250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFZ77_10270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ77_10275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HFZ77_10290	COG2885	chlorophyll binding
HFZ77_10300	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HFZ77_10310	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HFZ77_10310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ77_10320	COG0741	lytic transglycosylase activity
HFZ77_10325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFZ77_10350	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HFZ77_10355	COG3257	ureidoglycine aminohydrolase activity
HFZ77_10365	COG2351	hydroxyisourate hydrolase activity
HFZ77_10370	COG1012	belongs to the aldehyde dehydrogenase family
HFZ77_10390	COG2897	thiosulfate sulfurtransferase activity
HFZ77_10395	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HFZ77_10400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HFZ77_10410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HFZ77_10415	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HFZ77_10430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFZ77_10430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HFZ77_10440	COG0138	bifunctional purine biosynthesis protein purh
HFZ77_10445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HFZ77_10455	COG0612	Peptidase, M16
HFZ77_10460	COG0612	Peptidase, M16
HFZ77_10485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HFZ77_10505	COG1185	polyribonucleotide nucleotidyltransferase activity
HFZ77_10510	COG0450	alkyl hydroperoxide reductase
HFZ77_10525	COG0564	pseudouridine synthase activity
HFZ77_10555	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ77_10565	COG0405	Gamma-glutamyltransferase
HFZ77_10590	COG1674	ftsk spoiiie
HFZ77_10590	COG1674	ftsk spoiiie
HFZ77_10595	COG0436	Aminotransferase
HFZ77_10605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFZ77_10630	COG1174	glycine betaine transport
HFZ77_10635	COG1125	glycine betaine transport
HFZ77_10640	COG1174	glycine betaine transport
HFZ77_10645	COG1732	Glycine betaine
HFZ77_10680	COG1137	ATPase activity
HFZ77_10690	COG1012	belongs to the aldehyde dehydrogenase family
HFZ77_10700	COG0625	glutathione transferase activity
HFZ77_10705	COG2808	Putative FMN-binding domain
HFZ77_10710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HFZ77_10715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HFZ77_10725	COG1737	Transcriptional regulator
HFZ77_10755	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HFZ77_10755	COG3264	Mechanosensitive ion channel
HFZ77_10785	COG0312	modulator of DNA gyrase
HFZ77_10800	COG1519	Transferase
HFZ77_10805	COG1663	tetraacyldisaccharide 4'-kinase activity
HFZ77_10820	COG0745	RESPONSE REGULATOR receiver
HFZ77_10830	COG0708	Exodeoxyribonuclease III
HFZ77_10850	COG2835	tetraacyldisaccharide 4'-kinase activity
HFZ77_10860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HFZ77_10920	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HFZ77_10990	COG1418	mRNA catabolic process
HFZ77_10995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HFZ77_11000	COG4143	(ABC) transporter
HFZ77_11010	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HFZ77_11025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HFZ77_11030	COG0142	geranyltranstransferase activity
HFZ77_11035	COG1722	exodeoxyribonuclease VII activity
HFZ77_11040	COG0123	including yeast histone deacetylase and acetoin utilization protein
HFZ77_11050	COG0745	RESPONSE REGULATOR receiver
HFZ77_11055	COG1846	Transcriptional regulator
HFZ77_11060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFZ77_11070	COG1176	ABC-type spermidine putrescine transport system, permease component I
HFZ77_11080	COG3842	ATPase activity
HFZ77_11085	COG0006	proline dipeptidase activity
HFZ77_11100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HFZ77_11105	COG3842	ATPase activity
HFZ77_11110	COG1176	ABC-type spermidine putrescine transport system, permease component I
HFZ77_11115	COG1177	transmembrane transport
HFZ77_11120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ77_11130	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_11140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFZ77_11145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFZ77_11150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HFZ77_11160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ77_11175	COG1968	undecaprenyl-diphosphatase activity
HFZ77_11190	COG3300	MHYT domain
HFZ77_11190	COG5001	Diguanylate cyclase
HFZ77_11220	COG3608	succinylglutamate desuccinylase aspartoacylase
HFZ77_11220	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HFZ77_11250	COG0583	DNA-binding transcription factor activity
HFZ77_11265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFZ77_11270	COG0747	negative chemotaxis
HFZ77_11280	COG4172	Belongs to the ABC transporter superfamily
HFZ77_11285	COG1349	DNA-binding transcription factor activity
HFZ77_11295	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HFZ77_11310	COG0588	phosphoglycerate mutase activity
HFZ77_11320	COG3273	potassium ion transport
HFZ77_11320	COG0471	metal ion transport
HFZ77_11325	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ77_11350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HFZ77_11355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HFZ77_11360	COG2350	Protein conserved in bacteria
HFZ77_11375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFZ77_11390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HFZ77_11395	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HFZ77_11405	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HFZ77_11410	COG1999	signal sequence binding
HFZ77_11425	COG0802	atpase or kinase
HFZ77_11430	COG3178	'Phosphotransferase
HFZ77_11435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFZ77_11445	COG1074	ATP-dependent DNA helicase activity
HFZ77_11460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HFZ77_11470	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HFZ77_11495	COG3030	protein affecting phage T7 exclusion by the F plasmid
HFZ77_11500	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HFZ77_11505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFZ77_11510	COG0237	dephospho-CoA kinase activity
HFZ77_11515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HFZ77_11520	COG0424	maF-like protein
HFZ77_11525	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HFZ77_11530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HFZ77_11535	COG0445	tRNA wobble uridine modification
HFZ77_11540	COG0357	Ribosomal RNA small subunit methyltransferase G
HFZ77_11555	COG2832	Protein of unknown function (DUF454)
HFZ77_11560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFZ77_11565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HFZ77_11570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HFZ77_11575	COG1420	regulation of RNA biosynthetic process
HFZ77_11580	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HFZ77_11585	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HFZ77_11590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HFZ77_11595	COG0280	phosphate acetyltransferase
HFZ77_11595	COG0281	malic enzyme
HFZ77_11600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ77_11605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFZ77_11620	COG0137	argininosuccinate synthase activity
HFZ77_11625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFZ77_11650	COG0494	nUDIX hydrolase
HFZ77_11655	COG0617	tRNA 3'-terminal CCA addition
HFZ77_11660	COG1132	(ABC) transporter
HFZ77_11695	COG2226	methyltransferase
HFZ77_11705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HFZ77_11710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFZ77_11720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFZ77_11730	COG0779	Required for maturation of 30S ribosomal subunits
HFZ77_11745	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HFZ77_11755	COG0494	nUDIX hydrolase
HFZ77_11760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HFZ77_11765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFZ77_11770	COG0653	protein targeting
HFZ77_11785	COG2003	Belongs to the UPF0758 family
HFZ77_11790	COG0484	heat shock protein binding
HFZ77_11795	COG0443	Heat shock 70 kDa protein
HFZ77_11815	COG1216	Glycosyl transferase, family 2
HFZ77_11845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ77_11850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HFZ77_11855	COG1137	ATPase activity
HFZ77_11860	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HFZ77_11880	COG1024	Enoyl-CoA hydratase
HFZ77_11935	COG1473	amidohydrolase
HFZ77_11945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ77_11960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFZ77_11970	COG0747	negative chemotaxis
HFZ77_11985	COG1522	sequence-specific DNA binding
HFZ77_12010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFZ77_12025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HFZ77_12035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HFZ77_12040	COG0268	Binds directly to 16S ribosomal RNA
HFZ77_12050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HFZ77_12055	COG2226	methyltransferase
HFZ77_12070	COG3454	Phosphonate metabolism
HFZ77_12085	COG4778	phosphonate C-P lyase system protein PhnL
HFZ77_12090	COG4107	phosphonate C-P lyase system protein PhnK
HFZ77_12095	COG3627	carbon phosphorus lyase activity
HFZ77_12100	COG3626	phosphonate metabolism
HFZ77_12110	COG3624	Phosphonate C-P lyase system protein PhnG
HFZ77_12115	COG2188	Transcriptional regulator
HFZ77_12120	COG3454	Phosphonate metabolism
HFZ77_12130	COG3639	organic phosphonate transmembrane transporter activity
HFZ77_12135	COG3639	organic phosphonate transmembrane transporter activity
HFZ77_12140	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HFZ77_12145	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HFZ77_12150	COG2755	lipolytic protein G-D-S-L family
HFZ77_12150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HFZ77_12165	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HFZ77_12175	COG0702	epimerase
HFZ77_12185	COG0463	Glycosyl transferase, family 2
HFZ77_12185	COG0457	Tetratricopeptide repeat
HFZ77_12195	COG0489	protein tyrosine kinase activity
HFZ77_12200	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HFZ77_12250	COG2814	Major facilitator Superfamily
HFZ77_12275	COG0583	DNA-binding transcription factor activity
HFZ77_12280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFZ77_12300	COG0747	negative chemotaxis
HFZ77_12310	COG2205	protein histidine kinase activity
HFZ77_12310	COG5002	protein histidine kinase activity
HFZ77_12310	COG0784	Response regulator, receiver
HFZ77_12320	COG0473	3-isopropylmalate dehydrogenase activity
HFZ77_12345	COG0066	3-isopropylmalate dehydratase activity
HFZ77_12350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HFZ77_12355	COG3264	Mechanosensitive ion channel
HFZ77_12355	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HFZ77_12360	COG0799	negative regulation of ribosome biogenesis
HFZ77_12365	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HFZ77_12370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HFZ77_12380	COG0793	Belongs to the peptidase S41A family
HFZ77_12385	COG1051	belongs to the nudix hydrolase family
HFZ77_12400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HFZ77_12410	COG1611	Belongs to the LOG family
HFZ77_12425	COG2171	N-acyltransferase activity
HFZ77_12450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ77_12455	COG2153	protein acetylation
HFZ77_12465	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ77_12470	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HFZ77_12495	COG0557	exoribonuclease II activity
HFZ77_12505	COG2951	lytic endotransglycosylase activity
HFZ77_12515	COG3830	Belongs to the UPF0237 family
HFZ77_12515	COG0560	Phosphoserine phosphatase
HFZ77_12520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HFZ77_12525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFZ77_12535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HFZ77_12540	COG0183	Belongs to the thiolase family
HFZ77_12545	COG4953	penicillin-binding protein 1C
HFZ77_12550	COG2373	Large extracellular alpha-helical protein
HFZ77_12560	COG3022	response to hydroperoxide
HFZ77_12565	COG0514	ATP-dependent DNA helicase (RecQ)
HFZ77_12585	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HFZ77_12595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HFZ77_12605	COG2271	Major facilitator Superfamily
HFZ77_12615	COG0443	Heat shock 70 kDa protein
HFZ77_12620	COG1335	isochorismatase
HFZ77_12630	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HFZ77_12675	COG0438	transferase activity, transferring glycosyl groups
HFZ77_12685	COG0438	transferase activity, transferring glycosyl groups
HFZ77_12715	COG0174	glutamine synthetase
HFZ77_12745	COG0625	glutathione transferase activity
HFZ77_12760	COG0495	leucyl-tRNA aminoacylation
HFZ77_12780	COG0457	Tetratricopeptide repeat
HFZ77_12785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HFZ77_12790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFZ77_12805	COG1194	a g-specific adenine glycosylase
HFZ77_12820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HFZ77_12840	COG1609	Transcriptional regulator
HFZ77_12855	COG1177	transmembrane transport
HFZ77_12860	COG1176	ABC-type spermidine putrescine transport system, permease component I
HFZ77_12865	COG3842	ATPase activity
HFZ77_12870	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HFZ77_12885	COG2223	nitrite transmembrane transporter activity
HFZ77_12890	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HFZ77_12895	COG1140	nitrate reductase beta subunit
HFZ77_12900	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HFZ77_12905	COG2181	nitrate reductase activity
HFZ77_12910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFZ77_12915	COG1618	nucleotide phosphatase activity, acting on free nucleotides
HFZ77_12915	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HFZ77_12920	COG0420	3'-5' exonuclease activity
HFZ77_12925	COG4717	serine-type aminopeptidase activity
HFZ77_12950	COG5441	Belongs to the UPF0261 family
HFZ77_12955	COG1012	belongs to the aldehyde dehydrogenase family
HFZ77_12980	COG0174	glutamine synthetase
HFZ77_12985	COG0519	Catalyzes the synthesis of GMP from XMP
HFZ77_12985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFZ77_13000	COG1414	Transcriptional regulator
HFZ77_13010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ77_13015	COG1959	2 iron, 2 sulfur cluster binding
HFZ77_13020	COG4988	ABC transporter
HFZ77_13025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HFZ77_13035	COG1294	oxidase, subunit
HFZ77_13045	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFZ77_13060	COG1012	belongs to the aldehyde dehydrogenase family
HFZ77_13065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ77_13070	COG1522	sequence-specific DNA binding
HFZ77_13110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HFZ77_13115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HFZ77_13120	COG0287	Prephenate dehydrogenase
HFZ77_13135	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HFZ77_13160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ77_13170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFZ77_13175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HFZ77_13180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HFZ77_13185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HFZ77_13190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HFZ77_13210	COG2226	methyltransferase
HFZ77_13210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFZ77_13210	COG0596	Alpha beta hydrolase
HFZ77_13220	COG2983	Belongs to the UPF0260 family
HFZ77_13230	COG2030	dehydratase
HFZ77_13240	COG1227	inorganic diphosphatase activity
HFZ77_13260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HFZ77_13265	COG0459	protein refolding
HFZ77_13270	COG2818	Glycosylase
HFZ77_13300	COG0300	oxidoreductase activity
HFZ77_13310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HFZ77_13320	COG1216	Glycosyl transferase, family 2
HFZ77_13330	COG2124	cytochrome p450
HFZ77_13340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HFZ77_13345	COG0737	Belongs to the 5'-nucleotidase family
HFZ77_13375	COG0625	glutathione transferase activity
HFZ77_13380	COG1970	mechanosensitive ion channel activity
HFZ77_13385	COG0686	Belongs to the AlaDH PNT family
HFZ77_13390	COG1522	sequence-specific DNA binding
HFZ77_13405	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFZ77_13410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HFZ77_13420	COG1063	alcohol dehydrogenase
HFZ77_13450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HFZ77_13455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HFZ77_13470	COG1162	GTPase activity
HFZ77_13480	COG0737	Belongs to the 5'-nucleotidase family
HFZ77_13485	COG2816	NAD+ diphosphatase activity
HFZ77_13555	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HFZ77_13570	COG0435	Glutathione S-transferase
HFZ77_13605	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFZ77_13615	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_13620	COG1309	transcriptional regulator
HFZ77_13625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFZ77_13665	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HFZ77_13670	COG0242	peptide deformylase activity
HFZ77_13675	COG0242	peptide deformylase activity
HFZ77_13680	COG0242	peptide deformylase activity
HFZ77_13685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HFZ77_13700	COG2860	membrane
HFZ77_13705	COG0328	RNA-DNA hybrid ribonuclease activity
HFZ77_13715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HFZ77_13725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFZ77_13730	COG1758	RNA polymerase activity
HFZ77_13735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFZ77_13745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HFZ77_13750	COG0736	holo-[acyl-carrier-protein] synthase activity
HFZ77_13755	COG0681	Belongs to the peptidase S26 family
HFZ77_13765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HFZ77_13780	COG1381	Involved in DNA repair and RecF pathway recombination
HFZ77_13795	COG0493	'glutamate synthase
HFZ77_13805	COG1309	transcriptional regulator
HFZ77_13810	COG1309	transcriptional regulator
HFZ77_13835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ77_13840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ77_13845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ77_13860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFZ77_13875	COG1024	Enoyl-CoA hydratase
HFZ77_13920	COG2197	response regulator
HFZ77_13940	COG1396	sequence-specific DNA binding
HFZ77_13965	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HFZ77_13970	COG0745	RESPONSE REGULATOR receiver
HFZ77_13975	COG2205	protein histidine kinase activity
HFZ77_13980	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HFZ77_13995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ77_14005	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ77_14025	COG3454	Phosphonate metabolism
HFZ77_14030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFZ77_14035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HFZ77_14055	COG3038	cytochrome b561
HFZ77_14060	COG2046	Belongs to the sulfate adenylyltransferase family
HFZ77_14060	COG0529	Catalyzes the synthesis of activated sulfate
HFZ77_14065	COG0492	ferredoxin-NADP+ reductase activity
HFZ77_14070	COG1522	sequence-specific DNA binding
HFZ77_14090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HFZ77_14105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HFZ77_14115	COG0336	Belongs to the RNA methyltransferase TrmD family
HFZ77_14120	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HFZ77_14130	COG0335	large ribosomal subunit rRNA binding
HFZ77_14135	COG0254	rRNA binding
HFZ77_14150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HFZ77_14155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HFZ77_14170	COG1435	thymidine kinase activity
HFZ77_14180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFZ77_14185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFZ77_14300	COG4397	Mu-like prophage major head subunit gpT
HFZ77_14400	COG0776	regulation of translation
HFZ77_14430	COG2801	Transposase and inactivated derivatives
HFZ77_14430	COG3415	Transposase
HFZ77_14475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ77_14495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HFZ77_14515	COG0596	Alpha beta hydrolase
HFZ77_14520	COG0625	glutathione transferase activity
HFZ77_14530	COG0673	inositol 2-dehydrogenase activity
HFZ77_14550	COG3181	Tripartite tricarboxylate transporter family receptor
HFZ77_14590	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HFZ77_14600	COG2186	Transcriptional regulator
HFZ77_14610	COG2084	Dehydrogenase
HFZ77_14620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFZ77_14625	COG1063	alcohol dehydrogenase
HFZ77_14630	COG0625	glutathione transferase activity
HFZ77_14635	COG0228	four-way junction DNA binding
HFZ77_14660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFZ77_14675	COG3228	Belongs to the MtfA family
HFZ77_14680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFZ77_14710	COG0356	it plays a direct role in the translocation of protons across the membrane
HFZ77_14715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFZ77_14720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HFZ77_14725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HFZ77_14730	COG0077	Prephenate dehydratase
HFZ77_14740	COG4166	transmembrane transport
HFZ77_14745	COG4174	ABC transporter (Permease)
HFZ77_14760	COG4172	Belongs to the ABC transporter superfamily
HFZ77_14770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFZ77_14775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ77_14800	COG2010	Cytochrome c
HFZ77_14810	COG0583	DNA-binding transcription factor activity
HFZ77_14815	COG0348	domain, Protein
HFZ77_14835	COG1686	Belongs to the peptidase S11 family
HFZ77_14845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HFZ77_14850	COG2813	Specifically methylates the guanine in position
HFZ77_14860	COG0408	coproporphyrinogen oxidase activity
HFZ77_14870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HFZ77_14875	COG3383	formate dehydrogenase (NAD+) activity
HFZ77_14895	COG0825	malonyl-CoA metabolic process
HFZ77_14905	COG2301	Belongs to the HpcH HpaI aldolase family
HFZ77_14915	COG4948	Mandelate Racemase Muconate Lactonizing
HFZ77_14925	COG3384	dioxygenase
HFZ77_14945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HFZ77_14950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ77_14955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HFZ77_14960	COG1268	BioY protein
HFZ77_14965	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HFZ77_14970	COG1122	ATPase activity
HFZ77_14980	COG1984	allophanate hydrolase subunit 2
HFZ77_14990	COG0439	Biotin carboxylase
HFZ77_15000	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HFZ77_15015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HFZ77_15050	COG2885	chlorophyll binding
HFZ77_15060	COG1702	phosphate starvation-inducible protein PhoH
HFZ77_15065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HFZ77_15070	COG1253	flavin adenine dinucleotide binding
HFZ77_15075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HFZ77_15080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HFZ77_15085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HFZ77_15090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HFZ77_15105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HFZ77_15110	COG1733	regulation of RNA biosynthetic process
HFZ77_15115	COG0778	Nitroreductase
HFZ77_15125	COG0539	negative regulation of cytoplasmic translation
HFZ77_15130	COG0776	regulation of translation
HFZ77_15140	COG0135	phosphoribosylanthranilate isomerase activity
HFZ77_15145	COG0133	tryptophan synthase activity
HFZ77_15175	COG0193	aminoacyl-tRNA hydrolase activity
HFZ77_15185	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HFZ77_15195	COG1304	FMN binding
HFZ77_15200	COG0159	tryptophan synthase activity
HFZ77_15205	COG0012	GTP binding
HFZ77_15215	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFZ77_15240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFZ77_15290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HFZ77_15295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HFZ77_15300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HFZ77_15305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HFZ77_15310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HFZ77_15320	COG0255	Belongs to the universal ribosomal protein uL29 family
HFZ77_15325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HFZ77_15330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HFZ77_15335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HFZ77_15340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HFZ77_15345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HFZ77_15350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HFZ77_15355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HFZ77_15360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HFZ77_15365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HFZ77_15370	COG1841	ribosomal large subunit assembly
HFZ77_15385	COG2205	protein histidine kinase activity
HFZ77_15390	COG0200	Binds to the 23S rRNA
HFZ77_15395	COG0201	protein transport
HFZ77_15400	COG0563	adenylate kinase activity
HFZ77_15410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HFZ77_15415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HFZ77_15420	COG0202	RNA polymerase activity
HFZ77_15425	COG0203	ribosomal protein L17
HFZ77_15430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFZ77_15435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFZ77_15440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HFZ77_15445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ77_15455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFZ77_15460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ77_15510	COG3191	aminopeptidase activity
HFZ77_15535	COG0583	DNA-binding transcription factor activity
HFZ77_15545	COG1335	isochorismatase
HFZ77_15555	COG0583	DNA-binding transcription factor activity
HFZ77_15560	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HFZ77_15565	COG1960	acyl-CoA dehydrogenase activity
HFZ77_15570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFZ77_15590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HFZ77_15595	COG0564	pseudouridine synthase activity
HFZ77_15600	COG0546	phosphoglycolate phosphatase activity
HFZ77_15610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ77_15615	COG4597	amino acid ABC transporter
HFZ77_15620	COG0765	amino acid transport
HFZ77_15625	COG1126	abc transporter atp-binding protein
HFZ77_15630	COG1846	Transcriptional regulator
HFZ77_15635	COG0697	spore germination
HFZ77_15640	COG2062	phosphohistidine phosphatase, SixA
HFZ77_15655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HFZ77_15660	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_15665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HFZ77_15675	COG0706	membrane insertase activity
HFZ77_15680	COG5001	Diguanylate cyclase
HFZ77_15685	COG0037	tRNA processing
HFZ77_15700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HFZ77_15705	COG0594	ribonuclease P activity
HFZ77_15710	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HFZ77_15720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFZ77_15725	COG4191	Histidine kinase
HFZ77_15750	COG4191	Histidine kinase
HFZ77_15755	COG2204	response regulator
HFZ77_15785	COG0701	Predicted permease
HFZ77_15790	COG0640	Transcriptional regulator
HFZ77_15800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HFZ77_15810	COG0798	PFAM Bile acid sodium symporter
HFZ77_15815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HFZ77_15820	COG0181	hydroxymethylbilane synthase activity
HFZ77_15835	COG0277	FAD linked oxidase domain protein
HFZ77_15840	COG3971	2-oxopent-4-enoate hydratase activity
HFZ77_15845	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ77_15855	COG3384	dioxygenase
HFZ77_15890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFZ77_15915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HFZ77_15920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HFZ77_15935	COG0540	Belongs to the ATCase OTCase family
HFZ77_15940	COG1573	uracil-dna glycosylase
HFZ77_15945	COG1280	lysine exporter protein (LysE YggA)
HFZ77_15950	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFZ77_15960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFZ77_15970	COG1678	Uncharacterized ACR, COG1678
HFZ77_15980	COG0523	cobalamin synthesis protein
HFZ77_15985	COG0523	cobalamin synthesis protein
HFZ77_15995	COG0735	belongs to the Fur family
HFZ77_16000	COG1121	(ABC) transporter
HFZ77_16005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFZ77_16015	COG0450	alkyl hydroperoxide reductase
HFZ77_16020	COG0783	Belongs to the Dps family
HFZ77_16040	COG0009	L-threonylcarbamoyladenylate synthase
HFZ77_16045	COG1960	acyl-CoA dehydrogenase activity
HFZ77_16085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFZ77_16095	COG0789	Transcriptional regulator
HFZ77_16110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HFZ77_16115	COG0142	geranyltranstransferase activity
HFZ77_16125	COG2890	protein-(glutamine-N5) methyltransferase activity
HFZ77_16140	COG0583	DNA-binding transcription factor activity
HFZ77_16160	COG5001	Diguanylate cyclase
HFZ77_16165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ77_16170	COG0165	Argininosuccinate lyase
HFZ77_16185	COG0019	diaminopimelate decarboxylase activity
HFZ77_16200	COG2205	protein histidine kinase activity
HFZ77_16200	COG0784	Response regulator, receiver
HFZ77_16210	COG1278	Cold shock
HFZ77_16215	COG3118	belongs to the thioredoxin family
HFZ77_16245	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HFZ77_16260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HFZ77_16300	COG2072	flavoprotein involved in K transport
HFZ77_16305	COG0385	Bile acid
HFZ77_16310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ77_16315	COG0300	oxidoreductase activity
HFZ77_16320	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFZ77_16330	COG4771	TonB-dependent receptor
HFZ77_16345	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HFZ77_16355	COG0811	peptide transport
HFZ77_16360	COG0848	biopolymer transport protein
HFZ77_16390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HFZ77_16400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HFZ77_16405	COG2186	Transcriptional regulator
HFZ77_16410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFZ77_16430	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ77_16445	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HFZ77_16450	COG1984	allophanate hydrolase subunit 2
HFZ77_16455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HFZ77_16465	COG0587	DNA-directed DNA polymerase activity
HFZ77_16470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFZ77_16485	COG0729	surface antigen
HFZ77_16525	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_16535	COG1733	regulation of RNA biosynthetic process
HFZ77_16560	COG0798	PFAM Bile acid sodium symporter
HFZ77_16600	COG0702	epimerase
HFZ77_16625	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFZ77_16635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HFZ77_16650	COG0583	DNA-binding transcription factor activity
HFZ77_16655	COG0604	alcohol dehydrogenase
HFZ77_16660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ77_16695	COG0745	RESPONSE REGULATOR receiver
HFZ77_16740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFZ77_16770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFZ77_16775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFZ77_16810	COG2188	Transcriptional regulator
HFZ77_16815	COG3842	ATPase activity
HFZ77_16825	COG1177	transmembrane transport
HFZ77_16830	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_16835	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_16845	COG3842	ATPase activity
HFZ77_16860	COG0523	cobalamin synthesis protein
HFZ77_16900	COG0701	Predicted permease
HFZ77_16910	COG3119	arylsulfatase activity
HFZ77_16915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ77_16920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFZ77_16940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFZ77_16945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ77_16950	COG0022	dehydrogenase e1 component
HFZ77_16950	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ77_16955	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ77_16960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFZ77_16965	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HFZ77_16975	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
HFZ77_16980	COG3259	Nickel-dependent hydrogenase
HFZ77_16995	COG4176	ABC-type proline glycine betaine transport system permease component
HFZ77_17000	COG4175	Glycine betaine
HFZ77_17000	COG0517	IMP dehydrogenase activity
HFZ77_17010	COG0746	molybdenum cofactor guanylyltransferase activity
HFZ77_17035	COG1024	Enoyl-CoA hydratase
HFZ77_17040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFZ77_17045	COG1024	Enoyl-CoA hydratase
HFZ77_17045	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ77_17050	COG0183	Belongs to the thiolase family
HFZ77_17060	COG0559	Belongs to the binding-protein-dependent transport system permease family
HFZ77_17090	COG1960	acyl-CoA dehydrogenase activity
HFZ77_17105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ77_17110	COG0101	tRNA pseudouridine synthase activity
HFZ77_17115	COG3106	COG3106 Predicted ATPase
HFZ77_17125	COG3768	UPF0283 membrane protein
HFZ77_17135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HFZ77_17140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFZ77_17145	COG1183	phosphatidylcholine synthase activity
HFZ77_17160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HFZ77_17170	COG2391	methyltransferase activity
HFZ77_17180	COG1136	(ABC) transporter
HFZ77_17190	COG3483	tryptophan 2,3-dioxygenase activity
HFZ77_17200	COG0481	GTPase activity
HFZ77_17210	COG0187	DNA topoisomerase II activity
HFZ77_17215	COG0784	Response regulator, receiver
HFZ77_17215	COG2205	protein histidine kinase activity
HFZ77_17220	COG0596	Alpha beta hydrolase
HFZ77_17225	COG2326	polyphosphate kinase activity
HFZ77_17235	COG0534	Mate efflux family protein
HFZ77_17295	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HFZ77_17300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HFZ77_17320	COG1278	Cold shock
HFZ77_17325	COG1393	Belongs to the ArsC family
HFZ77_17345	COG3220	belongs to the UPF0276 family
HFZ77_17355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HFZ77_17375	COG1522	sequence-specific DNA binding
HFZ77_17420	COG0583	DNA-binding transcription factor activity
HFZ77_17425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HFZ77_17430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ77_17435	COG0174	glutamine synthetase
HFZ77_17440	COG0519	Catalyzes the synthesis of GMP from XMP
HFZ77_17445	COG0174	glutamine synthetase
HFZ77_17455	COG4215	(ABC) transporter
HFZ77_17490	COG0504	CTP synthase activity
HFZ77_17510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HFZ77_17530	COG0625	glutathione transferase activity
HFZ77_17540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HFZ77_17550	COG1902	pentaerythritol trinitrate reductase activity
HFZ77_17550	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFZ77_17625	COG3842	ATPase activity
HFZ77_17635	COG1177	transmembrane transport
HFZ77_17650	COG0577	efflux transmembrane transporter activity
HFZ77_17650	COG1136	(ABC) transporter
HFZ77_17655	COG0577	efflux transmembrane transporter activity
HFZ77_17655	COG1136	(ABC) transporter
HFZ77_17660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFZ77_17680	COG1744	ABC transporter substrate-binding protein PnrA-like
HFZ77_17685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ77_17710	COG0583	DNA-binding transcription factor activity
HFZ77_17740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ77_17750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ77_17760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ77_17765	COG0842	Transport permease protein
HFZ77_17770	COG1131	(ABC) transporter
HFZ77_17805	COG0583	DNA-binding transcription factor activity
HFZ77_17815	COG0784	Response regulator, receiver
HFZ77_17815	COG4191	Histidine kinase
HFZ77_17830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ77_17855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFZ77_17860	COG2080	2 iron, 2 sulfur cluster binding
HFZ77_17880	COG0124	histidyl-tRNA synthetase
HFZ77_17885	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HFZ77_17890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HFZ77_17900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFZ77_17905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HFZ77_17925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HFZ77_17940	COG1492	cobalamin metabolic process
HFZ77_17955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HFZ77_17960	COG0354	folic acid binding
HFZ77_17980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HFZ77_18000	COG1309	transcriptional regulator
HFZ77_18010	COG1162	GTPase activity
HFZ77_18045	COG0564	pseudouridine synthase activity
HFZ77_18065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFZ77_18070	COG1278	Cold shock
HFZ77_18080	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ77_18095	COG0457	Tetratricopeptide repeat
HFZ77_18105	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HFZ77_18110	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HFZ77_18115	COG1329	Transcriptional regulator
HFZ77_18120	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HFZ77_18125	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HFZ77_18135	COG1522	sequence-specific DNA binding
HFZ77_18175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HFZ77_18180	COG1024	Enoyl-CoA hydratase
HFZ77_18185	COG0525	valine-tRNA ligase activity
HFZ77_18195	COG1116	anion transmembrane transporter activity
HFZ77_18195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ77_18200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ77_18205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ77_18220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFZ77_18225	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HFZ77_18265	COG0583	DNA-binding transcription factor activity
HFZ77_18270	COG0483	inositol monophosphate 1-phosphatase activity
HFZ77_18275	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HFZ77_18280	COG1304	FMN binding
HFZ77_18295	COG0489	protein tyrosine kinase activity
HFZ77_18305	COG2001	Belongs to the MraZ family
HFZ77_18310	COG0275	rRNA processing
HFZ77_18325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HFZ77_18335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HFZ77_18340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HFZ77_18360	COG2095	MarC family integral membrane protein
HFZ77_18370	COG3474	cytochrome
HFZ77_18375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HFZ77_18385	COG0321	lipoyl(octanoyl) transferase activity
HFZ77_18420	COG0405	Gamma-glutamyltransferase
HFZ77_18435	COG0601	transmembrane transport
HFZ77_18440	COG4608	Belongs to the ABC transporter superfamily
HFZ77_18445	COG0444	Belongs to the ABC transporter superfamily
HFZ77_18450	COG0583	DNA-binding transcription factor activity
HFZ77_18455	COG4566	intracellular signal transduction
HFZ77_18460	COG0837	glucose binding
HFZ77_18465	COG1522	sequence-specific DNA binding
HFZ77_18470	COG0506	proline dehydrogenase activity
HFZ77_18470	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HFZ77_18470	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HFZ77_18485	COG0069	glutamate synthase activity
HFZ77_18495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFZ77_18495	COG0574	Belongs to the PEP-utilizing enzyme family
HFZ77_18500	COG0582	viral genome integration into host DNA
HFZ77_18505	COG0321	lipoyl(octanoyl) transferase activity
HFZ77_18505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HFZ77_18510	COG0084	hydrolase, TatD family'
HFZ77_18520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HFZ77_18525	COG1686	Belongs to the peptidase S11 family
HFZ77_18560	COG2873	o-acetylhomoserine
HFZ77_18580	COG0513	Belongs to the DEAD box helicase family
HFZ77_18590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HFZ77_18595	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HFZ77_18600	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_18615	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HFZ77_18620	COG1283	sodium-dependent phosphate transmembrane transporter activity
HFZ77_18645	COG1127	ABC transporter
HFZ77_18650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFZ77_18655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFZ77_18660	COG0305	Participates in initiation and elongation during chromosome replication
HFZ77_18665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HFZ77_18670	COG0418	dihydroorotase activity
HFZ77_18700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HFZ77_18710	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HFZ77_18770	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HFZ77_18775	COG0709	Synthesizes selenophosphate from selenide and ATP
HFZ77_18780	COG1648	precorrin-2 dehydrogenase activity
HFZ77_18780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFZ77_18785	COG0243	molybdopterin cofactor binding
HFZ77_18795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFZ77_18805	COG1116	anion transmembrane transporter activity
HFZ77_18810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ77_18815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ77_18820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ77_18820	COG1116	anion transmembrane transporter activity
HFZ77_18825	COG3707	response regulator
HFZ77_18835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HFZ77_18840	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HFZ77_18880	COG0375	protein maturation
HFZ77_18920	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HFZ77_18930	COG1987	bacterial-type flagellum assembly
HFZ77_18995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ77_19035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFZ77_19040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFZ77_19080	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ77_19085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HFZ77_19090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HFZ77_19105	COG1091	dTDP-4-dehydrorhamnose reductase activity
HFZ77_19110	COG1088	dTDP-glucose 4,6-dehydratase activity
HFZ77_19125	COG1192	Involved in chromosome partitioning
HFZ77_19130	COG1475	DNA binding
HFZ77_19185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFZ77_19195	COG0129	dihydroxy-acid dehydratase activity
HFZ77_19240	COG1216	Glycosyl transferase, family 2