locus-tag	class	description
KUV46_00005	COG0183	Belongs to the thiolase family
KUV46_00025	COG0492	ferredoxin-NADP+ reductase activity
KUV46_00035	COG1058	Belongs to the CinA family
KUV46_00035	COG1546	Belongs to the CinA family
KUV46_00045	COG1764	response to oxidative stress
KUV46_00050	COG2175	clavaminate synthase activity
KUV46_00060	COG0024	Methionine aminopeptidase
KUV46_00075	COG2003	Belongs to the UPF0758 family
KUV46_00085	COG1690	Belongs to the RtcB family
KUV46_00095	COG0435	Glutathione S-transferase
KUV46_00105	COG2814	Major facilitator Superfamily
KUV46_00110	COG2814	Major facilitator Superfamily
KUV46_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KUV46_00130	COG0328	RNA-DNA hybrid ribonuclease activity
KUV46_00145	COG0457	Tetratricopeptide repeat
KUV46_00150	COG4206	TonB-dependent receptor
KUV46_00165	COG1960	acyl-CoA dehydrogenase activity
KUV46_00175	COG0203	ribosomal protein L17
KUV46_00180	COG0202	RNA polymerase activity
KUV46_00185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KUV46_00190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KUV46_00195	COG0563	adenylate kinase activity
KUV46_00205	COG0200	Binds to the 23S rRNA
KUV46_00210	COG1841	ribosomal large subunit assembly
KUV46_00215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KUV46_00220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KUV46_00225	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KUV46_00230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KUV46_00235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KUV46_00245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KUV46_00250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KUV46_00255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KUV46_00260	COG0255	Belongs to the universal ribosomal protein uL29 family
KUV46_00265	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KUV46_00270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KUV46_00275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KUV46_00280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KUV46_00285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KUV46_00290	COG0089	rRNA binding
KUV46_00295	COG0088	Forms part of the polypeptide exit tunnel
KUV46_00300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KUV46_00305	COG0051	transcription antitermination factor activity, RNA binding
KUV46_00320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KUV46_00325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KUV46_00330	COG0049	tRNA binding
KUV46_00335	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KUV46_00340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KUV46_00345	COG0085	RNA polymerase activity
KUV46_00350	COG0222	ribosome binding
KUV46_00355	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KUV46_00360	COG0081	regulation of translation
KUV46_00365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KUV46_00370	COG0501	Belongs to the peptidase M48B family
KUV46_00375	COG0052	Belongs to the universal ribosomal protein uS2 family
KUV46_00385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KUV46_00395	COG2989	Protein conserved in bacteria
KUV46_00420	COG2095	MarC family integral membrane protein
KUV46_00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KUV46_00445	COG2032	superoxide dismutase activity
KUV46_00460	COG0741	lytic transglycosylase activity
KUV46_00465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KUV46_00470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KUV46_00485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KUV46_00495	COG0668	transmembrane transport
KUV46_00500	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_00555	COG2211	Major facilitator Superfamily
KUV46_00560	COG0583	DNA-binding transcription factor activity
KUV46_00570	COG3384	dioxygenase
KUV46_00575	COG0556	nucleotide-excision repair
KUV46_00600	COG2827	Endonuclease containing a URI domain
KUV46_00635	COG3264	Mechanosensitive ion channel
KUV46_00635	COG1196	nuclear chromosome segregation
KUV46_00650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KUV46_00655	COG0583	DNA-binding transcription factor activity
KUV46_00660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KUV46_00660	COG1648	precorrin-2 dehydrogenase activity
KUV46_00675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KUV46_00685	COG0175	sulfate reduction
KUV46_00700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KUV46_00730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KUV46_00750	COG4770	biotin carboxylase activity
KUV46_00755	COG3739	integral membrane protein
KUV46_00760	COG1024	Enoyl-CoA hydratase
KUV46_00775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KUV46_00785	COG0656	L-ascorbic acid biosynthetic process
KUV46_00795	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KUV46_00800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KUV46_00805	COG2205	protein histidine kinase activity
KUV46_00805	COG0784	Response regulator, receiver
KUV46_00810	COG1960	acyl-CoA dehydrogenase activity
KUV46_00820	COG2239	Acts as a magnesium transporter
KUV46_00830	COG0321	lipoyl(octanoyl) transferase activity
KUV46_00845	COG4770	biotin carboxylase activity
KUV46_00880	COG0339	signal peptide processing
KUV46_00905	COG4221	oxidoreductase activity
KUV46_00950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KUV46_00980	COG0546	phosphoglycolate phosphatase activity
KUV46_00985	COG0564	pseudouridine synthase activity
KUV46_00990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KUV46_00995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KUV46_01010	COG2133	pyrroloquinoline quinone binding
KUV46_01015	COG0564	pseudouridine synthase activity
KUV46_01020	COG4771	TonB-dependent receptor
KUV46_01075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KUV46_01085	COG4221	oxidoreductase activity
KUV46_01090	COG4122	O-methyltransferase activity
KUV46_01100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KUV46_01100	COG0574	Belongs to the PEP-utilizing enzyme family
KUV46_01110	COG0751	glycine-tRNA ligase activity
KUV46_01120	COG0752	glycyl-tRNA synthetase alpha subunit
KUV46_01140	COG0142	geranyltranstransferase activity
KUV46_01155	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KUV46_01160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KUV46_01175	COG1573	uracil-dna glycosylase
KUV46_01195	COG2200	EAL domain
KUV46_01240	COG0356	it plays a direct role in the translocation of protons across the membrane
KUV46_01245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KUV46_01250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KUV46_01255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KUV46_01270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KUV46_01280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KUV46_01290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KUV46_01325	COG0183	Belongs to the thiolase family
KUV46_01350	COG4953	penicillin-binding protein 1C
KUV46_01360	COG2081	HI0933 family
KUV46_01370	COG0753	catalase activity
KUV46_01390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KUV46_01395	COG1872	DUF167
KUV46_01430	COG2205	protein histidine kinase activity
KUV46_01430	COG0784	Response regulator, receiver
KUV46_01435	COG2154	pterin-4-alpha-carbinolamine dehydratase
KUV46_01445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KUV46_01450	COG2205	protein histidine kinase activity
KUV46_01460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KUV46_01475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KUV46_01485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KUV46_01485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KUV46_01495	COG4221	oxidoreductase activity
KUV46_01535	COG0671	phosphoesterase, PA-phosphatase related
KUV46_01555	COG1877	trehalose-phosphatase activity
KUV46_01560	COG3387	PFAM Glycoside hydrolase 15-related
KUV46_01580	COG1956	GAF domain-containing protein
KUV46_01595	COG0714	Associated with various cellular activities
KUV46_01625	COG2968	Membrane
KUV46_01630	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KUV46_01635	COG3273	potassium ion transport
KUV46_01635	COG0471	metal ion transport
KUV46_01640	COG0604	alcohol dehydrogenase
KUV46_01650	COG0432	Pfam Uncharacterised protein family UPF0047
KUV46_01660	COG1764	response to oxidative stress
KUV46_01665	COG1846	Transcriptional regulator
KUV46_01680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KUV46_01685	COG0358	DNA primase activity
KUV46_01705	COG0596	Alpha beta hydrolase
KUV46_01720	COG0505	Belongs to the CarA family
KUV46_01750	COG2995	paraquat-inducible protein a
KUV46_01760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KUV46_01770	COG1960	acyl-CoA dehydrogenase activity
KUV46_01785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KUV46_01790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KUV46_01800	COG1230	cation diffusion facilitator family transporter
KUV46_01805	COG0492	ferredoxin-NADP+ reductase activity
KUV46_01820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KUV46_01850	COG0596	Alpha beta hydrolase
KUV46_01855	COG0740	serine-type endopeptidase activity
KUV46_01865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KUV46_01875	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KUV46_01890	COG2857	Cytochrome c1
KUV46_01890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KUV46_01905	COG0408	coproporphyrinogen oxidase activity
KUV46_01915	COG0617	tRNA 3'-terminal CCA addition
KUV46_01925	COG0494	nUDIX hydrolase
KUV46_01935	COG0714	Associated with various cellular activities
KUV46_01975	COG0798	PFAM Bile acid sodium symporter
KUV46_01980	COG0640	Transcriptional regulator
KUV46_01990	COG2323	membrane
KUV46_02000	COG1846	Transcriptional regulator
KUV46_02025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KUV46_02050	COG0183	Belongs to the thiolase family
KUV46_02055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KUV46_02070	COG2264	protein methyltransferase activity
KUV46_02075	COG0006	proline dipeptidase activity
KUV46_02080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KUV46_02085	COG0497	DNA recombination
KUV46_02090	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KUV46_02095	COG1396	sequence-specific DNA binding
KUV46_02100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KUV46_02110	COG0849	cell division
KUV46_02120	COG1181	Belongs to the D-alanine--D-alanine ligase family
KUV46_02125	COG2116	formate transmembrane transporter activity
KUV46_02135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KUV46_02140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KUV46_02145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KUV46_02155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KUV46_02160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KUV46_02165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KUV46_02170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KUV46_02185	COG0275	rRNA processing
KUV46_02190	COG2001	Belongs to the MraZ family
KUV46_02195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KUV46_02200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KUV46_02205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KUV46_02210	COG0799	negative regulation of ribosome biogenesis
KUV46_02215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KUV46_02240	COG0842	Transport permease protein
KUV46_02245	COG0488	(ABC) transporter
KUV46_02255	COG0271	Belongs to the BolA IbaG family
KUV46_02260	COG2234	aminopeptidase activity
KUV46_02270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KUV46_02310	COG0047	phosphoribosylformylglycinamidine synthase activity
KUV46_02320	COG1054	Belongs to the UPF0176 family
KUV46_02330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KUV46_02335	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KUV46_02350	COG0739	heme binding
KUV46_02355	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_02375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KUV46_02395	COG2852	Protein conserved in bacteria
KUV46_02400	COG0037	tRNA processing
KUV46_02410	COG0701	Predicted permease
KUV46_02415	COG1476	TRANSCRIPTIONal
KUV46_02435	COG5640	endopeptidase activity
KUV46_02440	COG1228	amidohydrolase
KUV46_02450	COG2264	protein methyltransferase activity
KUV46_02465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KUV46_02470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KUV46_02475	COG0612	Peptidase, M16
KUV46_02480	COG0612	Peptidase, M16
KUV46_02490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KUV46_02495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KUV46_02505	COG0196	riboflavin kinase activity
KUV46_02510	COG2030	dehydratase
KUV46_02530	COG0179	Fumarylacetoacetate (FAA) hydrolase
KUV46_02550	COG0733	neurotransmitter:sodium symporter activity
KUV46_02555	COG0772	Belongs to the SEDS family
KUV46_02560	COG0768	penicillin binding
KUV46_02605	COG3447	MASE1 domain protein
KUV46_02605	COG5001	Diguanylate cyclase
KUV46_02605	COG5002	protein histidine kinase activity
KUV46_02610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KUV46_02615	COG0697	spore germination
KUV46_02630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KUV46_02645	COG0440	acetolactate synthase activity
KUV46_02650	COG0028	Belongs to the TPP enzyme family
KUV46_02655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KUV46_02660	COG0560	Phosphoserine phosphatase
KUV46_02660	COG3830	Belongs to the UPF0237 family
KUV46_02665	COG1605	Chorismate mutase
KUV46_02665	COG0077	Prephenate dehydratase
KUV46_02670	COG3474	cytochrome
KUV46_02685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KUV46_02695	COG0330	HflC and HflK could
KUV46_02700	COG0330	HflC and HflK could
KUV46_02705	COG0489	protein tyrosine kinase activity
KUV46_02740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KUV46_02800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KUV46_02805	COG0114	fumarate hydratase activity
KUV46_02825	COG0659	secondary active sulfate transmembrane transporter activity
KUV46_02865	COG1024	Enoyl-CoA hydratase
KUV46_02900	COG0210	DNA helicase
KUV46_02925	COG0745	RESPONSE REGULATOR receiver
KUV46_02935	COG1012	belongs to the aldehyde dehydrogenase family
KUV46_02955	COG0642	Histidine kinase
KUV46_02960	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KUV46_02965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KUV46_02970	COG0471	metal ion transport
KUV46_02980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KUV46_02985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KUV46_02990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KUV46_02995	COG3743	rRNA binding
KUV46_02995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KUV46_03010	COG1960	acyl-CoA dehydrogenase activity
KUV46_03015	COG0183	Belongs to the thiolase family
KUV46_03020	COG1024	Enoyl-CoA hydratase
KUV46_03020	COG1250	3-hydroxyacyl-CoA dehydrogenase
KUV46_03025	COG0427	acetyl-CoA hydrolase
KUV46_03030	COG2271	Major facilitator Superfamily
KUV46_03035	COG0583	DNA-binding transcription factor activity
KUV46_03050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KUV46_03070	COG2197	response regulator
KUV46_03075	COG2205	protein histidine kinase activity
KUV46_03080	COG0745	RESPONSE REGULATOR receiver
KUV46_03110	COG3119	arylsulfatase activity
KUV46_03120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KUV46_03135	COG2267	carboxylic ester hydrolase activity
KUV46_03185	COG1960	acyl-CoA dehydrogenase activity
KUV46_03190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KUV46_03200	COG2217	Heavy metal translocating P-type atpase
KUV46_03215	COG2010	Cytochrome c
KUV46_03240	COG4191	Histidine kinase
KUV46_03255	COG4206	TonB-dependent receptor
KUV46_03270	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KUV46_03305	COG2080	2 iron, 2 sulfur cluster binding
KUV46_03310	COG2010	Cytochrome c
KUV46_03310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KUV46_03320	COG0446	pyridine nucleotide-disulphide oxidoreductase
KUV46_03340	COG3258	Cytochrome c
KUV46_03350	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KUV46_03355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KUV46_03370	COG0521	Mo-molybdopterin cofactor biosynthetic process
KUV46_03375	COG0315	cyclic pyranopterin monophosphate synthase activity
KUV46_03385	COG3474	cytochrome
KUV46_03390	COG1846	Transcriptional regulator
KUV46_03400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KUV46_03405	COG1917	Cupin 2, conserved barrel domain protein
KUV46_03410	COG0527	aspartate kinase activity
KUV46_03420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KUV46_03450	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KUV46_03465	COG2853	Lipoprotein
KUV46_03470	COG2226	methyltransferase
KUV46_03490	COG2105	PFAM AIG2 family protein
KUV46_03510	COG0625	glutathione transferase activity
KUV46_03530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KUV46_03535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KUV46_03550	COG2902	Dehydrogenase
KUV46_03555	COG0628	permease
KUV46_03565	COG1476	TRANSCRIPTIONal
KUV46_03575	COG0433	COG0433 Predicted ATPase
KUV46_03625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KUV46_03630	COG0792	nuclease activity
KUV46_03645	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KUV46_03650	COG0189	ligase activity
KUV46_03660	COG0606	chelatase, subunit chli
KUV46_03670	COG2211	Major facilitator Superfamily
KUV46_03675	COG0280	phosphate acetyltransferase
KUV46_03675	COG0281	malic enzyme
KUV46_03680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KUV46_03685	COG3273	potassium ion transport
KUV46_03685	COG0471	metal ion transport
KUV46_03695	COG0405	Gamma-glutamyltransferase
KUV46_03700	COG1024	Enoyl-CoA hydratase
KUV46_03705	COG0268	Binds directly to 16S ribosomal RNA
KUV46_03710	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KUV46_03735	COG1024	Enoyl-CoA hydratase
KUV46_03800	COG2816	NAD+ diphosphatase activity
KUV46_03810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KUV46_03820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KUV46_03825	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KUV46_03830	COG4133	protoheme IX ABC transporter activity
KUV46_03835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KUV46_03880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KUV46_03885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KUV46_03890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KUV46_03895	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_03905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KUV46_03915	COG0347	Belongs to the P(II) protein family
KUV46_03925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KUV46_03935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KUV46_03940	COG0287	Prephenate dehydrogenase
KUV46_03950	COG0300	oxidoreductase activity
KUV46_03985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KUV46_03990	COG0228	four-way junction DNA binding
KUV46_04000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KUV46_04015	COG1301	dicarboxylic acid transport
KUV46_04035	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KUV46_04060	COG2900	Belongs to the SlyX family
KUV46_04080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KUV46_04110	COG1794	racemase activity, acting on amino acids and derivatives
KUV46_04125	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_04135	COG2267	carboxylic ester hydrolase activity
KUV46_04160	COG1393	Belongs to the ArsC family
KUV46_04180	COG0488	(ABC) transporter
KUV46_04185	COG1946	Acyl-CoA thioesterase
KUV46_04190	COG0318	PFAM AMP-dependent synthetase and ligase
KUV46_04195	COG1201	RNA secondary structure unwinding
KUV46_04210	COG1793	dna ligase
KUV46_04230	COG1960	acyl-CoA dehydrogenase activity
KUV46_04245	COG0183	Belongs to the thiolase family
KUV46_04255	COG1024	Enoyl-CoA hydratase
KUV46_04255	COG1250	3-hydroxyacyl-CoA dehydrogenase
KUV46_04265	COG2885	chlorophyll binding
KUV46_04275	COG0657	acetylesterase activity
KUV46_04290	COG1196	nuclear chromosome segregation
KUV46_04290	COG0741	lytic transglycosylase activity
KUV46_04290	COG0739	heme binding
KUV46_04295	COG0492	ferredoxin-NADP+ reductase activity
KUV46_04315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KUV46_04315	COG3153	acetyltransferase
KUV46_04320	COG0514	ATP-dependent DNA helicase (RecQ)
KUV46_04335	COG0123	including yeast histone deacetylase and acetoin utilization protein
KUV46_04340	COG0534	Mate efflux family protein
KUV46_04345	COG0167	dihydroorotate dehydrogenase activity
KUV46_04360	COG0583	DNA-binding transcription factor activity
KUV46_04365	COG0783	Belongs to the Dps family
KUV46_04370	COG0436	Aminotransferase
KUV46_04375	COG0322	excinuclease ABC activity
KUV46_04445	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KUV46_04455	COG0180	Tryptophanyl-tRNA synthetase
KUV46_04470	COG1999	signal sequence binding
KUV46_04480	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KUV46_04485	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KUV46_04510	COG3706	GGDEF domain
KUV46_04520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KUV46_04545	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KUV46_04555	COG4152	abc transporter atp-binding protein
KUV46_04570	COG2076	Multidrug Resistance protein
KUV46_04575	COG0825	malonyl-CoA metabolic process
KUV46_04605	COG2301	Belongs to the HpcH HpaI aldolase family
KUV46_04640	COG4974	Belongs to the 'phage' integrase family
KUV46_04645	COG1115	amino acid carrier protein
KUV46_04660	COG1643	Atp-dependent helicase
KUV46_04675	COG0302	gtp cyclohydrolase
KUV46_04685	COG0215	cysteine-tRNA ligase activity
KUV46_04710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KUV46_04715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KUV46_04745	COG1131	(ABC) transporter
KUV46_04755	COG3806	Anti-sigma factor
KUV46_04760	COG1595	DNA-templated transcription, initiation
KUV46_04770	COG2072	flavoprotein involved in K transport
KUV46_04775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KUV46_04795	COG0351	phosphomethylpyrimidine kinase
KUV46_04815	COG0384	phenazine biosynthesis protein PhzF
KUV46_04825	COG2175	clavaminate synthase activity
KUV46_04830	COG0697	spore germination
KUV46_04840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KUV46_04845	COG0655	NAD(P)H dehydrogenase (quinone) activity
KUV46_04855	COG2072	flavoprotein involved in K transport
KUV46_04860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KUV46_04900	COG2086	electron transfer activity
KUV46_04910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KUV46_04935	COG1250	3-hydroxyacyl-CoA dehydrogenase
KUV46_04940	COG2095	MarC family integral membrane protein
KUV46_04945	COG1846	Transcriptional regulator
KUV46_04965	COG0481	GTPase activity
KUV46_04970	COG1902	pentaerythritol trinitrate reductase activity
KUV46_04980	COG1024	Enoyl-CoA hydratase
KUV46_04995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KUV46_05005	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_05020	COG0284	orotidine-5'-phosphate decarboxylase activity
KUV46_05050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KUV46_05065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KUV46_05075	COG0037	tRNA processing
KUV46_05085	COG2885	chlorophyll binding
KUV46_05090	COG0823	Involved in the tonB-independent uptake of proteins
KUV46_05105	COG0811	peptide transport
KUV46_05110	COG0824	Thioesterase
KUV46_05115	COG0138	bifunctional purine biosynthesis protein purh
KUV46_05120	COG1086	Polysaccharide biosynthesis protein
KUV46_05140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KUV46_05140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KUV46_05145	COG0501	Belongs to the peptidase M48B family
KUV46_05150	COG5508	conserved small protein
KUV46_05165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KUV46_05195	COG1505	serine-type exopeptidase activity
KUV46_05200	COG0154	amidase activity
KUV46_05240	COG0604	alcohol dehydrogenase
KUV46_05240	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_05240	COG3321	synthase
KUV46_05245	COG0784	Response regulator, receiver
KUV46_05250	COG1072	(Pantothenic acid kinase))
KUV46_05270	COG2226	methyltransferase
KUV46_05275	COG1040	competence protein
KUV46_05280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KUV46_05295	COG0596	Alpha beta hydrolase
KUV46_05305	COG0494	nUDIX hydrolase
KUV46_05310	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KUV46_05315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KUV46_05320	COG0653	protein targeting
KUV46_05325	COG0668	transmembrane transport
KUV46_05340	COG3300	MHYT domain
KUV46_05340	COG5001	Diguanylate cyclase
KUV46_05350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KUV46_05360	COG1132	(ABC) transporter
KUV46_05365	COG0483	inositol monophosphate 1-phosphatase activity
KUV46_05370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KUV46_05380	COG0352	thiamine-phosphate diphosphorylase activity
KUV46_05385	COG0625	glutathione transferase activity
KUV46_05395	COG3588	fructose-bisphosphate aldolase
KUV46_05400	COG0126	phosphoglycerate kinase activity
KUV46_05430	COG0463	Glycosyl transferase, family 2
KUV46_05435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KUV46_05435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KUV46_05440	COG0588	phosphoglycerate mutase activity
KUV46_05445	COG2942	2-epimerase
KUV46_05465	COG0793	Belongs to the peptidase S41A family
KUV46_05475	COG1051	belongs to the nudix hydrolase family
KUV46_05485	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KUV46_05495	COG2884	Cell division ATP-binding protein ftsE
KUV46_05505	COG0318	PFAM AMP-dependent synthetase and ligase
KUV46_05505	COG0204	Acyl-transferase
KUV46_05540	COG0469	pyruvate kinase activity
KUV46_05545	COG0508	dehydrogenase complex catalyzes the overall conversion of
KUV46_05550	COG0567	Dehydrogenase, E1 component
KUV46_05555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KUV46_05560	COG0045	succinate-CoA ligase (ADP-forming) activity
KUV46_05600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KUV46_05605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KUV46_05610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KUV46_05615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KUV46_05675	COG1132	(ABC) transporter
KUV46_05680	COG0519	Catalyzes the synthesis of GMP from XMP
KUV46_05680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KUV46_05685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KUV46_05690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KUV46_05695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KUV46_05700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KUV46_05705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KUV46_05710	COG0784	Response regulator, receiver
KUV46_05720	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KUV46_05725	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KUV46_05730	COG2203	Gaf domain
KUV46_05730	COG3706	GGDEF domain
KUV46_05730	COG4251	negative regulation of phosphorylation
KUV46_05730	COG5001	Diguanylate cyclase
KUV46_05735	COG0131	Imidazoleglycerol-phosphate dehydratase
KUV46_05740	COG1473	amidohydrolase
KUV46_05745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KUV46_05750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KUV46_05755	COG0107	imidazoleglycerol-phosphate synthase activity
KUV46_05760	COG0140	phosphoribosyl-ATP diphosphatase activity
KUV46_05780	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KUV46_05785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KUV46_05790	COG0237	dephospho-CoA kinase activity
KUV46_05795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KUV46_05800	COG0424	maF-like protein
KUV46_05805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KUV46_05810	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KUV46_05815	COG1981	membrane
KUV46_05820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KUV46_05825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KUV46_05830	COG0445	tRNA wobble uridine modification
KUV46_05835	COG0357	Ribosomal RNA small subunit methyltransferase G
KUV46_05860	COG0495	leucyl-tRNA aminoacylation
KUV46_05880	COG0352	thiamine-phosphate diphosphorylase activity
KUV46_05885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KUV46_05895	COG0745	RESPONSE REGULATOR receiver
KUV46_05910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KUV46_05915	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KUV46_05935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KUV46_05940	COG0165	Argininosuccinate lyase
KUV46_05960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KUV46_05965	COG0552	protein localization to endoplasmic reticulum
KUV46_05970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KUV46_05985	COG2030	dehydratase
KUV46_06000	COG2301	Belongs to the HpcH HpaI aldolase family
KUV46_06025	COG0733	neurotransmitter:sodium symporter activity
KUV46_06030	COG2234	aminopeptidase activity
KUV46_06035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KUV46_06045	COG0473	3-isopropylmalate dehydrogenase activity
KUV46_06050	COG0066	3-isopropylmalate dehydratase activity
KUV46_06065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KUV46_06075	COG0335	large ribosomal subunit rRNA binding
KUV46_06105	COG2255	four-way junction helicase activity
KUV46_06110	COG0632	four-way junction helicase activity
KUV46_06115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KUV46_06170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KUV46_06175	COG2835	tetraacyldisaccharide 4'-kinase activity
KUV46_06185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KUV46_06190	COG0004	ammonium transporteR
KUV46_06195	COG1674	ftsk spoiiie
KUV46_06205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KUV46_06205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KUV46_06210	COG0217	transcriptional regulatory protein
KUV46_06220	COG1692	metallophosphoesterase
KUV46_06260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KUV46_06270	COG0457	Tetratricopeptide repeat
KUV46_06275	COG0596	Alpha beta hydrolase
KUV46_06290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KUV46_06295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KUV46_06310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KUV46_06315	COG0135	phosphoribosylanthranilate isomerase activity
KUV46_06320	COG0133	tryptophan synthase activity
KUV46_06335	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KUV46_06340	COG0285	dihydrofolate synthase activity
KUV46_06360	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_06370	COG1074	ATP-dependent DNA helicase activity
KUV46_06380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KUV46_06385	COG3178	'Phosphotransferase
KUV46_06390	COG0802	atpase or kinase
KUV46_06395	COG0626	cystathionine gamma-synthase activity
KUV46_06415	COG0633	Ferredoxin
KUV46_06430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KUV46_06445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KUV46_06450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KUV46_06455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KUV46_06460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KUV46_06475	COG4974	Belongs to the 'phage' integrase family
KUV46_06485	COG1024	Enoyl-CoA hydratase
KUV46_06490	COG4221	oxidoreductase activity
KUV46_06510	COG3750	Belongs to the UPF0335 family
KUV46_06515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KUV46_06535	COG0670	Belongs to the BI1 family
KUV46_06555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KUV46_06560	COG0463	Glycosyl transferase, family 2
KUV46_06585	COG1587	Uroporphyrinogen-III synthase
KUV46_06590	COG0181	hydroxymethylbilane synthase activity
KUV46_06595	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KUV46_06600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KUV46_06610	COG0288	reversible hydration of carbon dioxide
KUV46_06620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KUV46_06660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KUV46_06680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KUV46_06685	COG2201	protein-glutamate methylesterase activity
KUV46_06700	COG3784	Protein of unknown function (DUF1318)
KUV46_06715	COG0741	lytic transglycosylase activity
KUV46_06715	COG1196	nuclear chromosome segregation
KUV46_06715	COG0739	heme binding
KUV46_06730	COG0542	response to heat
KUV46_06745	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KUV46_06775	COG2957	Belongs to the agmatine deiminase family
KUV46_06800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KUV46_06800	COG3743	rRNA binding
KUV46_06845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KUV46_06845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KUV46_06880	COG2890	protein-(glutamine-N5) methyltransferase activity
KUV46_06885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KUV46_06925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KUV46_06950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KUV46_07005	COG1970	mechanosensitive ion channel activity
KUV46_07015	COG0539	negative regulation of cytoplasmic translation
KUV46_07020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KUV46_07025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KUV46_07030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KUV46_07035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KUV46_07050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KUV46_07070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KUV46_07075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KUV46_07080	COG3811	Belongs to the UPF0386 family
KUV46_07105	COG0572	uridine kinase
KUV46_07115	COG1185	polyribonucleotide nucleotidyltransferase activity
KUV46_07120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KUV46_07125	COG1902	pentaerythritol trinitrate reductase activity
KUV46_07135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KUV46_07140	COG1971	Probably functions as a manganese efflux pump
KUV46_07145	COG0668	transmembrane transport
KUV46_07155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KUV46_07165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KUV46_07180	COG0779	Required for maturation of 30S ribosomal subunits
KUV46_07190	COG1278	Cold shock
KUV46_07205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KUV46_07215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KUV46_07220	COG1396	sequence-specific DNA binding
KUV46_07225	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KUV46_07230	COG1253	flavin adenine dinucleotide binding
KUV46_07235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KUV46_07240	COG1702	phosphate starvation-inducible protein PhoH
KUV46_07245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KUV46_07260	COG1214	PFAM Peptidase M22, glycoprotease
KUV46_07265	COG0778	Nitroreductase
KUV46_07270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KUV46_07285	COG0657	acetylesterase activity
KUV46_07295	COG0318	PFAM AMP-dependent synthetase and ligase
KUV46_07325	COG1131	(ABC) transporter
KUV46_07345	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KUV46_07355	COG1842	Phage shock protein A
KUV46_07375	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KUV46_07375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KUV46_07390	COG2388	GCN5-related N-acetyl-transferase
KUV46_07400	COG2983	Belongs to the UPF0260 family
KUV46_07430	COG5001	Diguanylate cyclase
KUV46_07445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KUV46_07470	COG5285	phytanoyl-CoA dioxygenase
KUV46_07485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KUV46_07510	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KUV46_07520	COG0717	Belongs to the dCTP deaminase family
KUV46_07530	COG2967	ApaG domain
KUV46_07535	COG0697	spore germination
KUV46_07540	COG3023	N-Acetylmuramoyl-L-alanine amidase
KUV46_07580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KUV46_07580	COG0517	IMP dehydrogenase activity
KUV46_07600	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KUV46_07605	COG4771	TonB-dependent receptor
KUV46_07610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KUV46_07615	COG1218	3'(2'),5'-bisphosphate nucleotidase
KUV46_07630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KUV46_07635	COG0175	sulfate reduction
KUV46_07650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KUV46_07655	COG1083	cytidylyl-transferase
KUV46_07655	COG2755	lipolytic protein G-D-S-L family
KUV46_07660	COG1012	belongs to the aldehyde dehydrogenase family
KUV46_07690	COG1134	teichoic acid transport
KUV46_07700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KUV46_07705	COG1216	Glycosyl transferase, family 2
KUV46_07720	COG2089	acid synthase
KUV46_07775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KUV46_07800	COG1091	dTDP-4-dehydrorhamnose reductase activity
KUV46_07805	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
KUV46_07815	COG0545	Peptidyl-prolyl cis-trans isomerase
KUV46_07825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KUV46_07830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KUV46_07835	COG5001	Diguanylate cyclase
KUV46_07835	COG3300	MHYT domain
KUV46_07850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KUV46_07865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KUV46_07875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KUV46_07885	COG0756	dUTP diphosphatase activity
KUV46_07895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KUV46_07910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KUV46_07915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KUV46_07920	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KUV46_07925	COG1137	ATPase activity
KUV46_07940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KUV46_07970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KUV46_07970	COG1776	CheC inhibitor of MCP methylation
KUV46_07975	COG1338	Plays a role in the flagellum-specific transport system
KUV46_07985	COG1706	bacterial-type flagellum-dependent cell motility
KUV46_08000	COG1749	Flagellar hook protein flgE
KUV46_08015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KUV46_08025	COG4786	Flagellar basal body rod
KUV46_08030	COG4786	Flagellar basal body rod
KUV46_08040	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KUV46_08050	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KUV46_08090	COG1157	protein secretion by the type III secretion system
KUV46_08100	COG1558	bacterial-type flagellum-dependent cell motility
KUV46_08115	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KUV46_08120	COG1684	flagellar biosynthetic protein fliR
KUV46_08125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KUV46_08140	COG1968	undecaprenyl-diphosphatase activity
KUV46_08155	COG0484	heat shock protein binding
KUV46_08160	COG2267	carboxylic ester hydrolase activity
KUV46_08165	COG0438	transferase activity, transferring glycosyl groups
KUV46_08175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KUV46_08180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KUV46_08185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KUV46_08190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KUV46_08200	COG0072	phenylalanine-tRNA ligase activity
KUV46_08200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KUV46_08205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KUV46_08210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KUV46_08220	COG0604	alcohol dehydrogenase
KUV46_08225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KUV46_08240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KUV46_08240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KUV46_08245	COG1253	flavin adenine dinucleotide binding
KUV46_08250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KUV46_08255	COG2814	Major facilitator Superfamily
KUV46_08265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KUV46_08270	COG0527	aspartate kinase activity
KUV46_08305	COG4964	Belongs to the GSP D family
KUV46_08340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KUV46_08350	COG0583	DNA-binding transcription factor activity
KUV46_08375	COG2816	NAD+ diphosphatase activity
KUV46_08405	COG3046	protein related to deoxyribodipyrimidine photolyase
KUV46_08410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KUV46_08415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KUV46_08420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KUV46_08430	COG2133	pyrroloquinoline quinone binding
KUV46_08435	COG4771	TonB-dependent receptor
KUV46_08440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KUV46_08445	COG0602	queuosine metabolic process
KUV46_08460	COG1741	Belongs to the pirin family
KUV46_08465	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_08475	COG2070	2-Nitropropane dioxygenase
KUV46_08485	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_08495	COG0494	nUDIX hydrolase
KUV46_08505	COG0742	ribosomal rna small subunit methyltransferase
KUV46_08510	COG0590	tRNA wobble adenosine to inosine editing
KUV46_08525	COG3655	Transcriptional regulator
KUV46_08540	COG0494	nUDIX hydrolase
KUV46_08565	COG0513	Belongs to the DEAD box helicase family
KUV46_08570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KUV46_08575	COG2326	polyphosphate kinase activity
KUV46_08590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KUV46_08600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KUV46_08610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KUV46_08620	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KUV46_08645	COG0538	isocitrate dehydrogenase activity
KUV46_08665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KUV46_08675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KUV46_08695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KUV46_08705	COG0564	pseudouridine synthase activity
KUV46_08710	COG0686	Belongs to the AlaDH PNT family
KUV46_08715	COG0745	RESPONSE REGULATOR receiver
KUV46_08725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KUV46_08735	COG0573	inorganic phosphate transmembrane transporter activity
KUV46_08745	COG5002	protein histidine kinase activity
KUV46_08755	COG1566	PFAM secretion protein HlyD family protein
KUV46_08780	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_08780	COG3321	synthase
KUV46_08780	COG0604	alcohol dehydrogenase
KUV46_08790	COG0745	RESPONSE REGULATOR receiver
KUV46_08800	COG0183	Belongs to the thiolase family
KUV46_08820	COG1522	sequence-specific DNA binding
KUV46_08845	COG3706	GGDEF domain
KUV46_08885	COG1309	transcriptional regulator
KUV46_08895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KUV46_08900	COG1187	pseudouridine synthase activity
KUV46_08930	COG2827	Endonuclease containing a URI domain
KUV46_08945	COG0137	argininosuccinate synthase activity
KUV46_08965	COG0640	Transcriptional regulator
KUV46_08975	COG0693	protein deglycase activity
KUV46_08990	COG1217	gtp-binding protein TYPA
KUV46_09025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KUV46_09030	COG0823	Involved in the tonB-independent uptake of proteins
KUV46_09030	COG1506	peptidase
KUV46_09030	COG4946	Tricorn protease homolog
KUV46_09040	COG2226	methyltransferase
KUV46_09060	COG1794	racemase activity, acting on amino acids and derivatives
KUV46_09090	COG1704	LemA family
KUV46_09100	COG1024	Enoyl-CoA hydratase
KUV46_09140	COG3191	aminopeptidase activity
KUV46_09150	COG0405	Gamma-glutamyltransferase
KUV46_09155	COG3852	Histidine kinase
KUV46_09175	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KUV46_09185	COG0706	membrane insertase activity
KUV46_09190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KUV46_09230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KUV46_09250	COG2072	flavoprotein involved in K transport
KUV46_09260	COG3710	Transcriptional regulator
KUV46_09275	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_09280	COG0625	glutathione transferase activity
KUV46_09285	COG1902	pentaerythritol trinitrate reductase activity
KUV46_09290	COG2171	N-acyltransferase activity
KUV46_09300	COG0530	calcium, potassium:sodium antiporter activity
KUV46_09310	COG2226	methyltransferase
KUV46_09315	COG1012	belongs to the aldehyde dehydrogenase family
KUV46_09315	COG2030	dehydratase
KUV46_09335	COG2267	carboxylic ester hydrolase activity
KUV46_09355	COG0101	tRNA pseudouridine synthase activity
KUV46_09365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KUV46_09370	COG0242	peptide deformylase activity
KUV46_09400	COG0012	GTP binding
KUV46_09410	COG0193	aminoacyl-tRNA hydrolase activity
KUV46_09415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KUV46_09430	COG1012	belongs to the aldehyde dehydrogenase family
KUV46_09435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KUV46_09440	COG1496	oxidoreductase activity
KUV46_09450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KUV46_09470	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KUV46_09480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KUV46_09495	COG0745	RESPONSE REGULATOR receiver
KUV46_09505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KUV46_09515	COG0450	alkyl hydroperoxide reductase
KUV46_09535	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
KUV46_09555	COG1960	acyl-CoA dehydrogenase activity
KUV46_09565	COG1960	acyl-CoA dehydrogenase activity
KUV46_09570	COG0069	glutamate synthase activity
KUV46_09575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KUV46_09585	COG1115	amino acid carrier protein
KUV46_09590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KUV46_09595	COG1733	regulation of RNA biosynthetic process
KUV46_09610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KUV46_09620	COG0018	arginyl-trna synthetase
KUV46_09645	COG0735	belongs to the Fur family
KUV46_09650	COG3047	cAMP biosynthetic process
KUV46_09665	COG1960	acyl-CoA dehydrogenase activity
KUV46_09680	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
KUV46_09690	COG1741	Belongs to the pirin family
KUV46_09705	COG0519	Catalyzes the synthesis of GMP from XMP
KUV46_09710	COG0354	folic acid binding
KUV46_09715	COG1268	BioY protein
KUV46_09725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KUV46_09755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KUV46_09790	COG0300	oxidoreductase activity
KUV46_09790	COG0318	PFAM AMP-dependent synthetase and ligase
KUV46_09790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KUV46_09790	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_09790	COG3321	synthase
KUV46_09795	COG0028	Belongs to the TPP enzyme family
KUV46_09810	COG2226	methyltransferase
KUV46_09815	COG4221	oxidoreductase activity
KUV46_09820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KUV46_09825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KUV46_09835	COG3655	Transcriptional regulator
KUV46_09840	COG3045	CreA protein
KUV46_09860	COG1420	regulation of RNA biosynthetic process
KUV46_09865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KUV46_09875	COG0443	Heat shock 70 kDa protein
KUV46_09880	COG0668	transmembrane transport
KUV46_09885	COG1357	PFAM Pentapeptide repeats (8 copies)
KUV46_09920	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KUV46_09935	COG0482	sulfurtransferase activity
KUV46_09945	COG4774	siderophore transport
KUV46_09950	COG1285	pathogenesis
KUV46_09965	COG1271	oxidase subunit
KUV46_09970	COG1294	oxidase, subunit
KUV46_10000	COG0277	FAD linked oxidase domain protein
KUV46_10010	COG0009	L-threonylcarbamoyladenylate synthase
KUV46_10015	COG2353	YceI-like domain
KUV46_10030	COG1960	acyl-CoA dehydrogenase activity
KUV46_10035	COG0778	Nitroreductase
KUV46_10060	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KUV46_10085	COG0517	IMP dehydrogenase activity
KUV46_10085	COG1125	glycine betaine transport
KUV46_10090	COG1174	glycine betaine transport
KUV46_10115	COG4771	TonB-dependent receptor
KUV46_10130	COG1462	curli production assembly transport component CsgG
KUV46_10140	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KUV46_10230	COG0583	DNA-binding transcription factor activity
KUV46_10245	COG1960	acyl-CoA dehydrogenase activity
KUV46_10250	COG1024	Enoyl-CoA hydratase
KUV46_10265	COG0729	surface antigen
KUV46_10290	COG3321	synthase
KUV46_10290	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_10290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KUV46_10290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KUV46_10290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KUV46_10305	COG2070	2-Nitropropane dioxygenase
KUV46_10305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KUV46_10325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KUV46_10330	COG1940	carbohydrate kinase activity
KUV46_10335	COG1960	acyl-CoA dehydrogenase activity
KUV46_10340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KUV46_10345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KUV46_10350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KUV46_10355	COG0730	response to heat
KUV46_10370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KUV46_10375	COG1960	acyl-CoA dehydrogenase activity
KUV46_10385	COG1960	acyl-CoA dehydrogenase activity
KUV46_10395	COG1024	Enoyl-CoA hydratase
KUV46_10400	COG0251	oxidation-reduction process
KUV46_10410	COG2211	Major facilitator Superfamily
KUV46_10415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KUV46_10430	COG3128	pkhd-type hydroxylase
KUV46_10445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KUV46_10455	COG1757	Na H antiporter
KUV46_10475	COG1957	nucleoside hydrolase
KUV46_10480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KUV46_10505	COG2819	hydrolase of the alpha beta superfamily
KUV46_10555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KUV46_10575	COG0346	lactoylglutathione lyase activity
KUV46_10580	COG2080	2 iron, 2 sulfur cluster binding
KUV46_10585	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KUV46_10590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KUV46_10600	COG2015	COG2015, Alkyl sulfatase and related hydrolases
KUV46_10610	COG0800	Aldolase
KUV46_10615	COG0837	glucose binding
KUV46_10625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KUV46_10630	COG2909	trisaccharide binding
KUV46_10635	COG2205	protein histidine kinase activity
KUV46_10635	COG2198	Histidine kinase
KUV46_10635	COG0784	Response regulator, receiver
KUV46_10665	COG2391	methyltransferase activity
KUV46_10680	COG0582	viral genome integration into host DNA
KUV46_10705	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KUV46_10710	COG3421	Type III restriction
KUV46_10725	COG2945	thiolester hydrolase activity
KUV46_10725	COG0596	Alpha beta hydrolase
KUV46_10740	COG4771	TonB-dependent receptor
KUV46_10745	COG1960	acyl-CoA dehydrogenase activity
KUV46_10755	COG0318	PFAM AMP-dependent synthetase and ligase
KUV46_10785	COG0457	Tetratricopeptide repeat
KUV46_10790	COG4771	TonB-dependent receptor
KUV46_10795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KUV46_10820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KUV46_10835	COG1595	DNA-templated transcription, initiation
KUV46_10845	COG1024	Enoyl-CoA hydratase
KUV46_10860	COG0366	Alpha amylase catalytic
KUV46_10875	COG0587	DNA-directed DNA polymerase activity
KUV46_10905	COG2308	Evidence 4 Homologs of previously reported genes of
KUV46_10905	COG2307	Protein conserved in bacteria
KUV46_10945	COG4964	Belongs to the GSP D family
KUV46_10950	COG1012	belongs to the aldehyde dehydrogenase family
KUV46_10955	COG0006	proline dipeptidase activity
KUV46_10960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KUV46_10965	COG1473	amidohydrolase
KUV46_10980	COG1573	uracil-dna glycosylase
KUV46_10995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KUV46_11000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KUV46_11010	COG2072	flavoprotein involved in K transport
KUV46_11020	COG2885	chlorophyll binding
KUV46_11020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KUV46_11030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KUV46_11070	COG1024	Enoyl-CoA hydratase
KUV46_11090	COG1863	multisubunit Na H antiporter MnhE subunit
KUV46_11095	COG2212	antiporter activity
KUV46_11100	COG1320	monovalent cation:proton antiporter activity
KUV46_11120	COG0651	ATP synthesis coupled electron transport
KUV46_11125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KUV46_11125	COG2111	Na H antiporter
KUV46_11135	COG0651	ATP synthesis coupled electron transport
KUV46_11140	COG4957	zinc ion binding
KUV46_11170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KUV46_11175	COG2166	iron-sulfur cluster assembly
KUV46_11185	COG2205	protein histidine kinase activity
KUV46_11200	COG1435	thymidine kinase activity
KUV46_11220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KUV46_11225	COG0039	L-malate dehydrogenase activity
KUV46_11230	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_11235	COG0259	pyridoxamine-phosphate oxidase activity
KUV46_11260	COG0318	PFAM AMP-dependent synthetase and ligase
KUV46_11265	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_11280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KUV46_11300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KUV46_11315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KUV46_11320	COG0124	histidyl-tRNA synthetase
KUV46_11335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KUV46_11360	COG1295	ribonuclease BN
KUV46_11375	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KUV46_11375	COG3264	Mechanosensitive ion channel
KUV46_11385	COG4251	negative regulation of phosphorylation
KUV46_11395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KUV46_11400	COG0006	proline dipeptidase activity
KUV46_11415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KUV46_11425	COG0628	permease
KUV46_11440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KUV46_11455	COG2130	NADP-dependent
KUV46_11475	COG4695	Portal protein
KUV46_11545	COG0484	heat shock protein binding
KUV46_11565	COG4235	cytochrome complex assembly
KUV46_11575	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KUV46_11580	COG1138	Cytochrome C-type biogenesis protein
KUV46_11595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KUV46_11605	COG5002	protein histidine kinase activity
KUV46_11610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KUV46_11620	COG1595	DNA-templated transcription, initiation
KUV46_11695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KUV46_11705	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_11720	COG0488	(ABC) transporter
KUV46_11730	COG0300	oxidoreductase activity
KUV46_11740	COG2070	2-Nitropropane dioxygenase
KUV46_11760	COG0823	Involved in the tonB-independent uptake of proteins
KUV46_11760	COG1506	peptidase
KUV46_11765	COG4771	TonB-dependent receptor
KUV46_11780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KUV46_11790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KUV46_11795	COG5328	Belongs to the UPF0262 family
KUV46_11800	COG3920	Histidine kinase
KUV46_11805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KUV46_11810	COG0424	maF-like protein
KUV46_11845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KUV46_11850	COG0629	single-stranded DNA binding
KUV46_11855	COG0804	urea catabolic process
KUV46_11875	COG1960	acyl-CoA dehydrogenase activity
KUV46_11880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KUV46_11895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KUV46_11900	COG0343	queuine tRNA-ribosyltransferase activity
KUV46_11925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KUV46_11930	COG0250	Participates in transcription elongation, termination and antitermination
KUV46_11935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KUV46_11960	COG0489	protein tyrosine kinase activity
KUV46_11985	COG0110	maltose O-acetyltransferase activity
KUV46_12000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KUV46_12025	COG0438	transferase activity, transferring glycosyl groups
KUV46_12045	COG0438	transferase activity, transferring glycosyl groups
KUV46_12075	COG2308	Evidence 4 Homologs of previously reported genes of
KUV46_12110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KUV46_12115	COG0577	efflux transmembrane transporter activity
KUV46_12115	COG1136	(ABC) transporter
KUV46_12135	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KUV46_12145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KUV46_12150	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KUV46_12155	COG2080	2 iron, 2 sulfur cluster binding
KUV46_12160	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KUV46_12190	COG1760	l-serine dehydratase
KUV46_12200	COG0681	Belongs to the peptidase S26 family
KUV46_12220	COG0142	geranyltranstransferase activity
KUV46_12225	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KUV46_12235	COG0318	PFAM AMP-dependent synthetase and ligase
KUV46_12240	COG0667	Aldo Keto reductase
KUV46_12270	COG2824	Alkylphosphonate utilization operon protein PhnA
KUV46_12290	COG0459	protein refolding
KUV46_12300	COG5425	PFAM Usg family protein
KUV46_12310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KUV46_12320	COG2363	Small membrane protein
KUV46_12325	COG2072	flavoprotein involved in K transport
KUV46_12350	COG4948	Mandelate Racemase Muconate Lactonizing
KUV46_12355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KUV46_12360	COG1127	ABC transporter
KUV46_12375	COG2202	Pas domain
KUV46_12375	COG2205	protein histidine kinase activity
KUV46_12380	COG0308	aminopeptidase N
KUV46_12390	COG1960	acyl-CoA dehydrogenase activity
KUV46_12395	COG1960	acyl-CoA dehydrogenase activity
KUV46_12405	COG2267	carboxylic ester hydrolase activity
KUV46_12420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KUV46_12455	COG3031	protein transport across the cell outer membrane
KUV46_12465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KUV46_12475	COG2165	general secretion pathway protein
KUV46_12525	COG1024	Enoyl-CoA hydratase
KUV46_12530	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_12535	COG1960	acyl-CoA dehydrogenase activity
KUV46_12540	COG1960	acyl-CoA dehydrogenase activity
KUV46_12555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KUV46_12570	COG0525	valine-tRNA ligase activity
KUV46_12575	COG1446	asparaginase
KUV46_12585	COG0667	Aldo Keto reductase
KUV46_12595	COG0129	dihydroxy-acid dehydratase activity
KUV46_12610	COG0308	aminopeptidase N
KUV46_12615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KUV46_12640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KUV46_12650	COG0187	DNA topoisomerase II activity
KUV46_12655	COG1573	uracil-dna glycosylase
KUV46_12665	COG1758	RNA polymerase activity
KUV46_12675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KUV46_12680	COG0736	holo-[acyl-carrier-protein] synthase activity
KUV46_12685	COG0571	ribonuclease III activity
KUV46_12695	COG1381	Involved in DNA repair and RecF pathway recombination
KUV46_12705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KUV46_12710	COG1704	LemA family
KUV46_12715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KUV46_12725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KUV46_12730	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KUV46_12735	COG0490	domain, Protein
KUV46_12735	COG0471	metal ion transport
KUV46_12745	COG2084	Dehydrogenase
KUV46_12760	COG2027	D-alanyl-D-alanine carboxypeptidase
KUV46_12765	COG0113	porphobilinogen synthase activity
KUV46_12800	COG0544	peptidyl-prolyl cis-trans isomerase activity
KUV46_12810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KUV46_12810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KUV46_12825	COG0347	Belongs to the P(II) protein family
KUV46_12830	COG0174	glutamine synthetase
KUV46_12835	COG0740	serine-type endopeptidase activity
KUV46_12840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KUV46_12865	COG2202	Pas domain
KUV46_12865	COG2205	protein histidine kinase activity
KUV46_12880	COG1741	Belongs to the pirin family
KUV46_12885	COG1573	uracil-dna glycosylase
KUV46_12900	COG1530	ribonuclease E activity
KUV46_12905	COG0860	N-Acetylmuramoyl-L-alanine amidase
KUV46_12925	COG0739	heme binding
KUV46_12930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KUV46_12940	COG3956	TIGRFAM MazG family protein
KUV46_12945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KUV46_12945	COG0321	lipoyl(octanoyl) transferase activity
KUV46_12950	COG0084	hydrolase, TatD family'
KUV46_12965	COG1686	Belongs to the peptidase S11 family
KUV46_12975	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KUV46_12985	COG0175	sulfate reduction
KUV46_12990	COG3002	Belongs to the UPF0753 family
KUV46_12995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KUV46_13000	COG0583	DNA-binding transcription factor activity
KUV46_13015	COG0583	DNA-binding transcription factor activity
KUV46_13025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KUV46_13030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KUV46_13040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KUV46_13065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KUV46_13065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KUV46_13070	COG0415	Belongs to the DNA photolyase family
KUV46_13085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KUV46_13105	COG2897	thiosulfate sulfurtransferase activity
KUV46_13110	COG0626	cystathionine gamma-synthase activity
KUV46_13120	COG1899	peptidyl-lysine modification to peptidyl-hypusine
KUV46_13125	COG1024	Enoyl-CoA hydratase
KUV46_13135	COG5001	Diguanylate cyclase
KUV46_13135	COG3300	MHYT domain
KUV46_13140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KUV46_13155	COG0776	regulation of translation
KUV46_13160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KUV46_13165	COG0416	fatty acid biosynthetic process
KUV46_13180	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KUV46_13185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KUV46_13190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KUV46_13195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KUV46_13215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KUV46_13220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KUV46_13225	COG0156	8-amino-7-oxononanoate synthase activity
KUV46_13230	COG0235	Class ii aldolase
KUV46_13235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KUV46_13240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KUV46_13245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KUV46_13250	COG1862	Preprotein translocase
KUV46_13275	COG2151	metal-sulfur cluster biosynthetic enzyme
KUV46_13280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KUV46_13290	COG0396	ATPase activity
KUV46_13305	COG0719	Fe-S assembly protein
KUV46_13310	COG1104	cysteine desulfurase activity
KUV46_13315	COG2945	thiolester hydrolase activity
KUV46_13320	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KUV46_13325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KUV46_13330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KUV46_13335	COG1923	regulation of RNA biosynthetic process
KUV46_13340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KUV46_13345	COG0569	domain protein
KUV46_13350	COG2204	response regulator
KUV46_13355	COG5000	phosphorelay sensor kinase activity
KUV46_13360	COG2204	response regulator
KUV46_13370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KUV46_13375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KUV46_13375	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KUV46_13380	COG1546	Belongs to the CinA family
KUV46_13380	COG1058	Belongs to the CinA family
KUV46_13390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KUV46_13400	COG4067	protein conserved in archaea
KUV46_13400	COG0189	ligase activity
KUV46_13425	COG0668	transmembrane transport
KUV46_13435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KUV46_13440	COG0508	dehydrogenase complex catalyzes the overall conversion of
KUV46_13450	COG0508	dehydrogenase complex catalyzes the overall conversion of
KUV46_13450	COG0022	dehydrogenase e1 component
KUV46_13455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KUV46_13465	COG0148	phosphopyruvate hydratase activity
KUV46_13470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KUV46_13475	COG0504	CTP synthase activity
KUV46_13485	COG0149	triose-phosphate isomerase activity
KUV46_13495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KUV46_13505	COG1193	negative regulation of DNA recombination
KUV46_13510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KUV46_13515	COG0134	indole-3-glycerol-phosphate synthase activity
KUV46_13520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KUV46_13525	COG0658	competence protein
KUV46_13525	COG2333	competence protein COMEC
KUV46_13530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KUV46_13540	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KUV46_13545	COG3494	Protein of unknown function (DUF1009)
KUV46_13550	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KUV46_13555	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KUV46_13565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KUV46_13570	COG0750	zinc metalloprotease
KUV46_13585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KUV46_13590	COG0233	cytoplasmic translational termination
KUV46_13595	COG0528	UMP kinase activity
KUV46_13600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KUV46_13605	COG0052	Belongs to the universal ribosomal protein uS2 family
KUV46_13615	COG1136	(ABC) transporter
KUV46_13625	COG0442	prolyl-tRNA aminoacylation
KUV46_13635	COG0346	lactoylglutathione lyase activity
KUV46_13645	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KUV46_13655	COG1007	ATP synthesis coupled electron transport
KUV46_13670	COG0713	ATP synthesis coupled electron transport
KUV46_13680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KUV46_13685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KUV46_13700	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KUV46_13705	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KUV46_13710	COG0649	NAD binding
KUV46_13715	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KUV46_13720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KUV46_13770	COG1278	Cold shock
KUV46_13780	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KUV46_13780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KUV46_13795	COG0436	Aminotransferase
KUV46_13805	COG3243	poly(R)-hydroxyalkanoic acid synthase
KUV46_13810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KUV46_13815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KUV46_13820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KUV46_13830	COG1612	heme a metabolic process
KUV46_13845	COG5265	(ABC) transporter
KUV46_13855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KUV46_13870	COG0673	inositol 2-dehydrogenase activity
KUV46_13875	COG2130	NADP-dependent
KUV46_13885	COG0776	regulation of translation
KUV46_13890	COG0534	Mate efflux family protein
KUV46_13895	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KUV46_13900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KUV46_13905	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KUV46_13910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KUV46_13915	COG0546	phosphoglycolate phosphatase activity
KUV46_13930	COG2121	Domain of unknown function (DUF374)
KUV46_13935	COG1519	Transferase
KUV46_13940	COG1663	tetraacyldisaccharide 4'-kinase activity
KUV46_13955	COG1187	pseudouridine synthase activity
KUV46_13965	COG3047	cAMP biosynthetic process
KUV46_13965	COG2885	chlorophyll binding
KUV46_13990	COG0151	Belongs to the GarS family
KUV46_14000	COG1570	exodeoxyribonuclease VII activity
KUV46_14010	COG0330	HflC and HflK could
KUV46_14015	COG0678	peroxiredoxin activity
KUV46_14015	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KUV46_14020	COG1678	Uncharacterized ACR, COG1678
KUV46_14025	COG2199	diguanylate cyclase activity
KUV46_14025	COG2200	EAL domain
KUV46_14025	COG2203	Gaf domain
KUV46_14050	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KUV46_14060	COG0109	protoheme IX farnesyltransferase activity
KUV46_14065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KUV46_14080	COG0312	modulator of DNA gyrase
KUV46_14090	COG3104	oligopeptide transport
KUV46_14100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KUV46_14110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KUV46_14120	COG1132	(ABC) transporter
KUV46_14130	COG0312	modulator of DNA gyrase
KUV46_14135	COG0076	glutamate decarboxylase activity
KUV46_14140	COG0534	Mate efflux family protein
KUV46_14145	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KUV46_14160	COG0625	glutathione transferase activity
KUV46_14170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KUV46_14185	COG1028	Short-chain dehydrogenase reductase Sdr
KUV46_14195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KUV46_14200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KUV46_14205	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KUV46_14210	COG0805	protein transport
KUV46_14215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KUV46_14220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KUV46_14225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KUV46_14230	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KUV46_14235	COG1472	Belongs to the glycosyl hydrolase 3 family
KUV46_14245	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KUV46_14250	COG0316	Belongs to the HesB IscA family
KUV46_14270	COG3300	MHYT domain
KUV46_14270	COG5001	Diguanylate cyclase
KUV46_14295	COG1253	flavin adenine dinucleotide binding
KUV46_14305	COG1566	PFAM secretion protein HlyD family protein
KUV46_14310	COG2814	Major facilitator Superfamily
KUV46_14315	COG0612	Peptidase, M16
KUV46_14325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KUV46_14330	COG0513	Belongs to the DEAD box helicase family
KUV46_14340	COG1012	belongs to the aldehyde dehydrogenase family
KUV46_14345	COG1024	Enoyl-CoA hydratase
KUV46_14360	COG1960	acyl-CoA dehydrogenase activity
KUV46_14375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KUV46_14375	COG2022	thiamine diphosphate biosynthetic process
KUV46_14380	COG1840	ABC-type Fe3 transport system, periplasmic component
KUV46_14400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KUV46_14405	COG2022	thiamine diphosphate biosynthetic process
KUV46_14420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KUV46_14425	COG0511	ligase activity, forming carbon-carbon bonds
KUV46_14430	COG0439	Biotin carboxylase
KUV46_14435	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KUV46_14455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KUV46_14470	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KUV46_14475	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KUV46_14480	COG0248	Ppx GppA phosphatase
KUV46_14485	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KUV46_14500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KUV46_14505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KUV46_14515	COG0105	UTP biosynthetic process
KUV46_14530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KUV46_14545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KUV46_14545	COG1754	DNA topoisomerase type I activity
KUV46_14550	COG0557	exoribonuclease II activity
KUV46_14560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KUV46_14575	COG0784	Response regulator, receiver
KUV46_14580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KUV46_14605	COG0537	adenosine 5'-monophosphoramidase activity
KUV46_14610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KUV46_14625	COG0154	amidase activity
KUV46_14635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KUV46_14640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KUV46_14650	COG0540	Belongs to the ATCase OTCase family
KUV46_14655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KUV46_14665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KUV46_14670	COG0758	DNA mediated transformation
KUV46_14675	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KUV46_14680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KUV46_14685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KUV46_14690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KUV46_14695	COG0194	GDP metabolic process
KUV46_14700	COG1561	YicC-like family, N-terminal region
KUV46_14705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KUV46_14710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KUV46_14715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KUV46_14725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KUV46_14730	COG0360	Binds together with S18 to 16S ribosomal RNA
KUV46_14735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KUV46_14740	COG0359	binds to the 23S rRNA
KUV46_14745	COG0305	Participates in initiation and elongation during chromosome replication
KUV46_14750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KUV46_14755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KUV46_14760	COG1127	ABC transporter
KUV46_14785	COG1286	toxin biosynthetic process
KUV46_14790	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KUV46_14795	COG0300	oxidoreductase activity
KUV46_14805	COG1160	GTP binding
KUV46_14810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KUV46_14820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KUV46_14900	COG0789	Transcriptional regulator
KUV46_14915	COG2217	Heavy metal translocating P-type atpase
KUV46_14935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KUV46_14940	COG1937	Protein conserved in bacteria
KUV46_14955	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KUV46_14980	COG1742	UPF0060 membrane protein
KUV46_15030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KUV46_15035	COG1061	Type III restriction enzyme res subunit
KUV46_15050	COG1002	Type II restriction enzyme, methylase subunits
KUV46_15060	COG4962	Type ii secretion system protein e
KUV46_15075	COG3451	type IV secretory pathway VirB4
KUV46_15085	COG3846	protein secretion by the type IV secretion system
KUV46_15100	COG2948	multi-organism process
KUV46_15110	COG5489	Protein of unknown function (DUF736)
KUV46_15130	COG0582	viral genome integration into host DNA
KUV46_15135	COG0519	Catalyzes the synthesis of GMP from XMP
KUV46_15135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KUV46_15140	COG1476	TRANSCRIPTIONal
KUV46_15230	COG5001	Diguanylate cyclase
KUV46_15250	COG2199	diguanylate cyclase activity
KUV46_15260	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KUV46_15265	COG1530	ribonuclease E activity
KUV46_15270	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KUV46_15275	COG0248	Ppx GppA phosphatase
KUV46_15280	COG3785	DNA binding
KUV46_15285	COG0625	glutathione transferase activity
KUV46_15295	COG3186	Phenylalanine-4-hydroxylase
KUV46_15305	COG3724	N-succinylarginine dihydrolase activity
KUV46_15315	COG1012	belongs to the aldehyde dehydrogenase family
KUV46_15335	COG0626	cystathionine gamma-synthase activity
KUV46_15355	COG0848	biopolymer transport protein
KUV46_15360	COG0848	biopolymer transport protein
KUV46_15365	COG0811	peptide transport
KUV46_15370	COG0811	peptide transport
KUV46_15390	COG0616	signal peptide processing
KUV46_15410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KUV46_15420	COG2132	Multicopper oxidase
KUV46_15440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KUV46_15445	COG0363	glucosamine-6-phosphate deaminase activity
KUV46_15450	COG0166	Belongs to the GPI family
KUV46_15455	COG0250	Participates in transcription elongation, termination and antitermination
KUV46_15515	COG0784	Response regulator, receiver
KUV46_15520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KUV46_15525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KUV46_15745	COG1783	phage Terminase large subunit
KUV46_15790	COG3750	Belongs to the UPF0335 family
KUV46_15900	COG0484	heat shock protein binding