locus-tag	class	description
HUF19_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUF19_00015	COG0592	DNA-directed DNA polymerase activity
HUF19_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUF19_00040	COG2056	Na+-H+ antiporter family
HUF19_00080	COG0751	glycine-tRNA ligase activity
HUF19_00085	COG0752	glycyl-tRNA synthetase alpha subunit
HUF19_00100	COG0745	RESPONSE REGULATOR receiver
HUF19_00110	COG1560	Kdo2-lipid A biosynthetic process
HUF19_00120	COG1595	DNA-templated transcription, initiation
HUF19_00125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUF19_00130	COG0569	domain protein
HUF19_00140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUF19_00145	COG0242	peptide deformylase activity
HUF19_00155	COG0758	DNA mediated transformation
HUF19_00180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUF19_00210	COG0217	transcriptional regulatory protein
HUF19_00230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUF19_00235	COG0339	signal peptide processing
HUF19_00260	COG0165	Argininosuccinate lyase
HUF19_00265	COG3275	phosphorelay sensor kinase activity
HUF19_00275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUF19_00305	COG0181	hydroxymethylbilane synthase activity
HUF19_00315	COG2959	enzyme of heme biosynthesis
HUF19_00330	COG0668	transmembrane transport
HUF19_00340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUF19_00345	COG2363	Small membrane protein
HUF19_00350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUF19_00395	COG0488	(ABC) transporter
HUF19_00430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HUF19_00440	COG2918	glutathione biosynthetic process
HUF19_00445	COG2183	response to ionizing radiation
HUF19_00465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HUF19_00470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HUF19_00475	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUF19_00480	COG1011	Hydrolase
HUF19_00485	COG0494	nUDIX hydrolase
HUF19_00490	COG0784	Response regulator, receiver
HUF19_00490	COG2205	protein histidine kinase activity
HUF19_00495	COG1346	cytolysis
HUF19_00510	COG0628	permease
HUF19_00515	COG0745	RESPONSE REGULATOR receiver
HUF19_00525	COG0281	malic enzyme
HUF19_00565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUF19_00590	COG0006	proline dipeptidase activity
HUF19_00595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUF19_00600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUF19_00605	COG0501	Belongs to the peptidase M48B family
HUF19_00630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUF19_00635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUF19_00655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUF19_00680	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_00695	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_00700	COG1960	acyl-CoA dehydrogenase activity
HUF19_00720	COG1802	Transcriptional regulator
HUF19_00740	COG0411	ABC transporter
HUF19_00760	COG0347	Belongs to the P(II) protein family
HUF19_00765	COG0004	ammonium transporteR
HUF19_00780	COG0210	DNA helicase
HUF19_00785	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUF19_00795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUF19_00810	COG0494	nUDIX hydrolase
HUF19_00815	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HUF19_00820	COG3108	Peptidase M15
HUF19_00825	COG2989	Protein conserved in bacteria
HUF19_00835	COG0730	response to heat
HUF19_00845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUF19_00870	COG0318	PFAM AMP-dependent synthetase and ligase
HUF19_00905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUF19_00910	COG2813	Specifically methylates the guanine in position
HUF19_00910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUF19_00920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUF19_00930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUF19_00940	COG0527	aspartate kinase activity
HUF19_00945	COG1917	Cupin 2, conserved barrel domain protein
HUF19_00965	COG1846	Transcriptional regulator
HUF19_00990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUF19_00995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUF19_01000	COG0537	adenosine 5'-monophosphoramidase activity
HUF19_01005	COG0140	phosphoribosyl-ATP diphosphatase activity
HUF19_01010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUF19_01015	COG3391	amine dehydrogenase activity
HUF19_01025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUF19_01060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUF19_01070	COG1678	Uncharacterized ACR, COG1678
HUF19_01100	COG0840	transmembrane signaling receptor activity
HUF19_01105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUF19_01110	COG0643	Histidine kinase
HUF19_01110	COG0784	Response regulator, receiver
HUF19_01110	COG2198	Histidine kinase
HUF19_01115	COG2201	protein-glutamate methylesterase activity
HUF19_01135	COG0726	polysaccharide deacetylase
HUF19_01160	COG2194	sulfuric ester hydrolase activity
HUF19_01175	COG3562	capsule polysaccharide
HUF19_01180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUF19_01185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUF19_01195	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUF19_01215	COG4585	Histidine kinase
HUF19_01230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUF19_01235	COG5002	protein histidine kinase activity
HUF19_01235	COG0784	Response regulator, receiver
HUF19_01235	COG2205	protein histidine kinase activity
HUF19_01245	COG1785	Belongs to the alkaline phosphatase family
HUF19_01250	COG0121	glutamine amidotransferase
HUF19_01270	COG1177	transmembrane transport
HUF19_01275	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUF19_01280	COG3842	ATPase activity
HUF19_01285	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HUF19_01290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUF19_01315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUF19_01320	COG1981	membrane
HUF19_01330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUF19_01345	COG0316	Belongs to the HesB IscA family
HUF19_01365	COG0739	heme binding
HUF19_01405	COG0537	adenosine 5'-monophosphoramidase activity
HUF19_01410	COG1119	ATPase activity
HUF19_01415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUF19_01425	COG0129	dihydroxy-acid dehydratase activity
HUF19_01435	COG1687	branched-chain amino acid
HUF19_01440	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HUF19_01450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUF19_01455	COG0018	arginyl-trna synthetase
HUF19_01465	COG3739	integral membrane protein
HUF19_01475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUF19_01520	COG0514	ATP-dependent DNA helicase (RecQ)
HUF19_01535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUF19_01540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUF19_01540	COG0517	IMP dehydrogenase activity
HUF19_01555	COG0745	RESPONSE REGULATOR receiver
HUF19_01560	COG0642	Histidine kinase
HUF19_01580	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_01590	COG1024	Enoyl-CoA hydratase
HUF19_01595	COG1960	acyl-CoA dehydrogenase activity
HUF19_01600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUF19_01610	COG1309	transcriptional regulator
HUF19_01655	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HUF19_01660	COG1194	a g-specific adenine glycosylase
HUF19_01685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUF19_01690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUF19_01695	COG0107	imidazoleglycerol-phosphate synthase activity
HUF19_01710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUF19_01715	COG0277	FAD linked oxidase domain protein
HUF19_01750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUF19_01765	COG0067	glutamate synthase
HUF19_01765	COG0069	glutamate synthase activity
HUF19_01765	COG0070	glutamate synthase
HUF19_01770	COG0493	'glutamate synthase
HUF19_01780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUF19_01785	COG2111	Na H antiporter
HUF19_01785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUF19_01790	COG1006	Multisubunit Na H antiporter MnhC subunit
HUF19_01795	COG0651	ATP synthesis coupled electron transport
HUF19_01800	COG1863	multisubunit Na H antiporter MnhE subunit
HUF19_01805	COG2212	antiporter activity
HUF19_01810	COG1320	monovalent cation:proton antiporter activity
HUF19_01815	COG0784	Response regulator, receiver
HUF19_01815	COG0835	chemotaxis
HUF19_01820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUF19_01825	COG2873	o-acetylhomoserine
HUF19_01850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUF19_01860	COG1360	Flagellar Motor Protein
HUF19_01865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUF19_01870	COG1722	exodeoxyribonuclease VII activity
HUF19_01875	COG0142	geranyltranstransferase activity
HUF19_01880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUF19_01885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUF19_01885	COG4191	Histidine kinase
HUF19_01890	COG2204	response regulator
HUF19_01895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUF19_01900	COG2738	Putative neutral zinc metallopeptidase
HUF19_01910	COG1196	nuclear chromosome segregation
HUF19_01910	COG3264	Mechanosensitive ion channel
HUF19_01925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUF19_01935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUF19_01940	COG0254	rRNA binding
HUF19_01955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUF19_01975	COG1047	Peptidyl-prolyl cis-trans
HUF19_01980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUF19_01985	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUF19_01990	COG0840	transmembrane signaling receptor activity
HUF19_02000	COG0557	exoribonuclease II activity
HUF19_02005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUF19_02010	COG0668	transmembrane transport
HUF19_02020	COG3634	alkyl hydroperoxide reductase activity
HUF19_02045	COG0583	DNA-binding transcription factor activity
HUF19_02050	COG0439	Biotin carboxylase
HUF19_02055	COG0511	ligase activity, forming carbon-carbon bonds
HUF19_02055	COG5016	pyruvate
HUF19_02060	COG0288	reversible hydration of carbon dioxide
HUF19_02075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUF19_02120	COG0360	Binds together with S18 to 16S ribosomal RNA
HUF19_02125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUF19_02140	COG0305	Participates in initiation and elongation during chromosome replication
HUF19_02160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUF19_02200	COG2315	Protein conserved in bacteria
HUF19_02225	COG1846	Transcriptional regulator
HUF19_02230	COG1764	response to oxidative stress
HUF19_02235	COG1064	alcohol dehydrogenase
HUF19_02250	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUF19_02250	COG1902	pentaerythritol trinitrate reductase activity
HUF19_02280	COG4667	esterase of the alpha-beta hydrolase superfamily
HUF19_02375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUF19_02380	COG0583	DNA-binding transcription factor activity
HUF19_02385	COG1183	phosphatidylcholine synthase activity
HUF19_02390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUF19_02395	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HUF19_02450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUF19_02470	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HUF19_02480	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUF19_02505	COG0784	Response regulator, receiver
HUF19_02505	COG2205	protein histidine kinase activity
HUF19_02520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUF19_02525	COG0723	plastoquinol--plastocyanin reductase activity
HUF19_02530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUF19_02535	COG2857	Cytochrome c1
HUF19_02540	COG0625	glutathione transferase activity
HUF19_02545	COG2969	positive regulation of protein catabolic process
HUF19_02560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUF19_02565	COG0154	amidase activity
HUF19_02570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUF19_02575	COG1077	Cell shape determining protein MreB Mrl
HUF19_02580	COG1792	Involved in formation and maintenance of cell shape
HUF19_02590	COG0424	maF-like protein
HUF19_02595	COG1530	ribonuclease E activity
HUF19_02605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUF19_02615	COG2239	Acts as a magnesium transporter
HUF19_02625	COG1660	Displays ATPase and GTPase activities
HUF19_02645	COG1137	ATPase activity
HUF19_02650	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HUF19_02670	COG1127	ABC transporter
HUF19_02675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUF19_02680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUF19_02695	COG5007	Belongs to the BolA IbaG family
HUF19_02700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUF19_02705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUF19_02710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUF19_02715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUF19_02720	COG0753	catalase activity
HUF19_02725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUF19_02730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUF19_02740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUF19_02765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUF19_02780	COG1280	lysine exporter protein (LysE YggA)
HUF19_02795	COG0126	phosphoglycerate kinase activity
HUF19_02835	COG0840	transmembrane signaling receptor activity
HUF19_02850	COG1012	belongs to the aldehyde dehydrogenase family
HUF19_02865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUF19_02880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUF19_02900	COG1162	GTPase activity
HUF19_02905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUF19_02915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUF19_02930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUF19_02930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUF19_02935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUF19_02955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUF19_02990	COG0488	(ABC) transporter
HUF19_03000	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUF19_03005	COG0303	'Molybdopterin
HUF19_03010	COG1858	cytochrome C peroxidase
HUF19_03015	COG0629	single-stranded DNA binding
HUF19_03020	COG2814	Major facilitator Superfamily
HUF19_03025	COG2197	response regulator
HUF19_03060	COG0560	Phosphoserine phosphatase
HUF19_03060	COG3830	Belongs to the UPF0237 family
HUF19_03065	COG3706	GGDEF domain
HUF19_03075	COG1509	lysine 2,3-aminomutase activity
HUF19_03080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUF19_03085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HUF19_03115	COG1360	Flagellar Motor Protein
HUF19_03120	COG1162	GTPase activity
HUF19_03125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUF19_03140	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUF19_03140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUF19_03145	COG0802	atpase or kinase
HUF19_03150	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUF19_03155	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUF19_03160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUF19_03165	COG1923	regulation of RNA biosynthetic process
HUF19_03170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUF19_03175	COG0330	HflC and HflK could
HUF19_03180	COG0330	HflC and HflK could
HUF19_03190	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HUF19_03195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUF19_03210	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HUF19_03215	COG0235	Class ii aldolase
HUF19_03220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUF19_03225	COG0840	transmembrane signaling receptor activity
HUF19_03235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUF19_03240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUF19_03245	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUF19_03250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUF19_03255	COG0617	tRNA 3'-terminal CCA addition
HUF19_03265	COG3852	Histidine kinase
HUF19_03275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUF19_03280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUF19_03285	COG0436	Aminotransferase
HUF19_03290	COG1489	DNA binding
HUF19_03305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUF19_03325	COG0417	DNA replication proofreading
HUF19_03330	COG0598	Magnesium transport protein CorA
HUF19_03335	COG1730	sister chromatid segregation
HUF19_03360	COG1858	cytochrome C peroxidase
HUF19_03365	COG0647	UMP catabolic process
HUF19_03370	COG3148	PFAM DTW domain containing protein
HUF19_03380	COG0277	FAD linked oxidase domain protein
HUF19_03390	COG2861	carbohydrate metabolic process
HUF19_03395	COG0793	Belongs to the peptidase S41A family
HUF19_03400	COG4942	peptidase
HUF19_03405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUF19_03410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUF19_03415	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HUF19_03420	COG2133	pyrroloquinoline quinone binding
HUF19_03425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUF19_03455	COG3409	Peptidoglycan-binding domain 1 protein
HUF19_03455	COG3267	Type II secretory pathway component ExeA
HUF19_03465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUF19_03470	COG1459	type II secretion system
HUF19_03480	COG2165	general secretion pathway protein
HUF19_03510	COG2204	response regulator
HUF19_03515	COG3852	Histidine kinase
HUF19_03530	COG3094	Invasion gene expression up-regulator, SirB
HUF19_03545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUF19_03550	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUF19_03560	COG3706	GGDEF domain
HUF19_03570	COG2119	membrane
HUF19_03595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUF19_03605	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HUF19_03610	COG2894	cell division
HUF19_03615	COG0850	regulation of cytokinetic process
HUF19_03625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUF19_03630	COG0671	phosphoesterase, PA-phosphatase related
HUF19_03635	COG0438	transferase activity, transferring glycosyl groups
HUF19_03655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUF19_03685	COG0579	oxidoreductase
HUF19_03690	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HUF19_03725	COG0438	transferase activity, transferring glycosyl groups
HUF19_03750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUF19_03755	COG2951	lytic endotransglycosylase activity
HUF19_03760	COG0772	Belongs to the SEDS family
HUF19_03765	COG0768	penicillin binding
HUF19_03770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HUF19_03785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUF19_03805	COG0586	Pfam SNARE associated Golgi protein
HUF19_03820	COG3012	SEC-C Motif Domain Protein
HUF19_03835	COG1686	Belongs to the peptidase S11 family
HUF19_03840	COG2921	Belongs to the UPF0250 family
HUF19_03845	COG0321	lipoyl(octanoyl) transferase activity
HUF19_03850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUF19_03870	COG3118	belongs to the thioredoxin family
HUF19_03885	COG0142	geranyltranstransferase activity
HUF19_03890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUF19_03895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUF19_03900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUF19_03905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUF19_03910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HUF19_03915	COG0268	Binds directly to 16S ribosomal RNA
HUF19_03920	COG0728	peptidoglycan biosynthetic process
HUF19_03925	COG0196	riboflavin kinase activity
HUF19_03930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUF19_03935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUF19_03940	COG1047	Peptidyl-prolyl cis-trans
HUF19_03945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUF19_04005	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUF19_04005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUF19_04030	COG0028	Belongs to the TPP enzyme family
HUF19_04045	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HUF19_04050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUF19_04055	COG5002	protein histidine kinase activity
HUF19_04055	COG0784	Response regulator, receiver
HUF19_04060	COG0151	Belongs to the GarS family
HUF19_04065	COG0138	bifunctional purine biosynthesis protein purh
HUF19_04075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUF19_04090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUF19_04125	COG2354	Protein conserved in bacteria
HUF19_04130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HUF19_04135	COG0237	dephospho-CoA kinase activity
HUF19_04170	COG1115	amino acid carrier protein
HUF19_04180	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUF19_04200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUF19_04205	COG0546	phosphoglycolate phosphatase activity
HUF19_04220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUF19_04280	COG0737	Belongs to the 5'-nucleotidase family
HUF19_04290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUF19_04295	COG4628	conserved protein (DUF2132)
HUF19_04300	COG0842	Transport permease protein
HUF19_04305	COG0842	Transport permease protein
HUF19_04305	COG1129	ABC transporter
HUF19_04310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUF19_04335	COG1960	acyl-CoA dehydrogenase activity
HUF19_04340	COG0183	Belongs to the thiolase family
HUF19_04375	COG3630	sodium ion export across plasma membrane
HUF19_04380	COG0511	ligase activity, forming carbon-carbon bonds
HUF19_04380	COG5016	pyruvate
HUF19_04385	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HUF19_04390	COG0579	oxidoreductase
HUF19_04400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUF19_04450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUF19_04450	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUF19_04455	COG0509	glycine decarboxylation via glycine cleavage system
HUF19_04460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUF19_04495	COG0519	Catalyzes the synthesis of GMP from XMP
HUF19_04495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUF19_04500	COG3530	Putative quorum-sensing-regulated virulence factor
HUF19_04510	COG5001	Diguanylate cyclase
HUF19_04510	COG3300	MHYT domain
HUF19_04515	COG3123	guanosine phosphorylase activity
HUF19_04520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUF19_04520	COG4191	Histidine kinase
HUF19_04525	COG0513	Belongs to the DEAD box helicase family
HUF19_04580	COG0084	hydrolase, TatD family'
HUF19_04610	COG0189	ligase activity
HUF19_04615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUF19_04620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUF19_04635	COG0450	alkyl hydroperoxide reductase
HUF19_04650	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUF19_04655	COG2267	carboxylic ester hydrolase activity
HUF19_04655	COG2226	methyltransferase
HUF19_04665	COG0156	8-amino-7-oxononanoate synthase activity
HUF19_04690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUF19_04695	COG2001	Belongs to the MraZ family
HUF19_04700	COG0275	rRNA processing
HUF19_04715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUF19_04720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUF19_04725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUF19_04730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUF19_04735	COG0772	Belongs to the SEDS family
HUF19_04740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUF19_04745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUF19_04750	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUF19_04755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUF19_04775	COG0739	heme binding
HUF19_04780	COG0653	protein targeting
HUF19_04785	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUF19_04790	COG0494	nUDIX hydrolase
HUF19_04810	COG4535	Mg2 and Co2 transporter CorC
HUF19_04820	COG1702	phosphate starvation-inducible protein PhoH
HUF19_04825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUF19_04850	COG1309	transcriptional regulator
HUF19_04855	COG2814	Major facilitator Superfamily
HUF19_04865	COG0193	aminoacyl-tRNA hydrolase activity
HUF19_04870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUF19_04885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUF19_04890	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HUF19_04900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUF19_04905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUF19_04910	COG2890	protein-(glutamine-N5) methyltransferase activity
HUF19_04915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUF19_04920	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUF19_04930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUF19_04950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUF19_04970	COG0792	nuclease activity
HUF19_04975	COG3107	peptidoglycan biosynthetic process
HUF19_05005	COG3541	Predicted nucleotidyltransferase
HUF19_05030	COG2020	methyltransferase activity
HUF19_05035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUF19_05045	COG1024	Enoyl-CoA hydratase
HUF19_05050	COG2197	response regulator
HUF19_05055	COG0784	Response regulator, receiver
HUF19_05055	COG2198	Histidine kinase
HUF19_05055	COG2205	protein histidine kinase activity
HUF19_05060	COG0705	Rhomboid family
HUF19_05070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUF19_05075	COG1132	(ABC) transporter
HUF19_05125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUF19_05125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUF19_05150	COG0500	methyltransferase
HUF19_05160	COG2067	long-chain fatty acid transport protein
HUF19_05165	COG0348	domain, Protein
HUF19_05170	COG3604	Transcriptional regulator
HUF19_05225	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUF19_05245	COG0811	peptide transport
HUF19_05250	COG0811	peptide transport
HUF19_05255	COG0848	biopolymer transport protein
HUF19_05260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HUF19_05295	COG1024	Enoyl-CoA hydratase
HUF19_05345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUF19_05350	COG0481	GTPase activity
HUF19_05360	COG0571	ribonuclease III activity
HUF19_05365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUF19_05380	COG0736	holo-[acyl-carrier-protein] synthase activity
HUF19_05385	COG0784	Response regulator, receiver
HUF19_05385	COG5002	protein histidine kinase activity
HUF19_05385	COG2205	protein histidine kinase activity
HUF19_05395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUF19_05400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUF19_05405	COG3956	TIGRFAM MazG family protein
HUF19_05415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUF19_05420	COG0563	adenylate kinase activity
HUF19_05435	COG1968	undecaprenyl-diphosphatase activity
HUF19_05440	COG0742	ribosomal rna small subunit methyltransferase
HUF19_05450	COG1131	(ABC) transporter
HUF19_05465	COG2900	Belongs to the SlyX family
HUF19_05500	COG0105	UTP biosynthetic process
HUF19_05505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUF19_05515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUF19_05520	COG0124	histidyl-tRNA synthetase
HUF19_05535	COG1160	GTP binding
HUF19_05560	COG0587	DNA-directed DNA polymerase activity
HUF19_05565	COG2199	diguanylate cyclase activity
HUF19_05565	COG2200	EAL domain
HUF19_05565	COG2202	Pas domain
HUF19_05570	COG0037	tRNA processing
HUF19_05585	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUF19_05590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUF19_05605	COG4536	flavin adenine dinucleotide binding
HUF19_05615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUF19_05625	COG0432	Pfam Uncharacterised protein family UPF0047
HUF19_05635	COG3781	membrane
HUF19_05645	COG0488	(ABC) transporter
HUF19_05655	COG0242	peptide deformylase activity
HUF19_05680	COG0501	Belongs to the peptidase M48B family
HUF19_05700	COG0840	transmembrane signaling receptor activity
HUF19_05710	COG1960	acyl-CoA dehydrogenase activity
HUF19_05715	COG1917	Cupin 2, conserved barrel domain protein
HUF19_05715	COG2207	Transcriptional regulator
HUF19_05725	COG2832	Protein of unknown function (DUF454)
HUF19_05750	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HUF19_05765	COG4771	TonB-dependent receptor
HUF19_05790	COG2226	methyltransferase
HUF19_05795	COG0456	acetyltransferase
HUF19_05820	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUF19_05825	COG3112	Uncharacterised protein family (UPF0231)
HUF19_05830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUF19_05835	COG0418	dihydroorotase activity
HUF19_05845	COG0137	argininosuccinate synthase activity
HUF19_05850	COG1289	transmembrane transporter activity
HUF19_05870	COG0154	amidase activity
HUF19_05890	COG2197	response regulator
HUF19_05895	COG1451	nucleotide metabolic process
HUF19_05900	COG0583	DNA-binding transcription factor activity
HUF19_05965	COG0300	oxidoreductase activity
HUF19_05990	COG0784	Response regulator, receiver
HUF19_05990	COG2205	protein histidine kinase activity
HUF19_05990	COG5002	protein histidine kinase activity
HUF19_06035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUF19_06040	COG5001	Diguanylate cyclase
HUF19_06040	COG3706	GGDEF domain
HUF19_06040	COG2203	Gaf domain
HUF19_06040	COG4251	negative regulation of phosphorylation
HUF19_06045	COG0204	Acyl-transferase
HUF19_06055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUF19_06070	COG2203	Gaf domain
HUF19_06070	COG5001	Diguanylate cyclase
HUF19_06070	COG3706	GGDEF domain
HUF19_06070	COG4251	negative regulation of phosphorylation
HUF19_06120	COG4133	protoheme IX ABC transporter activity
HUF19_06125	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUF19_06145	COG1138	Cytochrome C-type biogenesis protein
HUF19_06150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUF19_06200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUF19_06215	COG3162	membrane
HUF19_06235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUF19_06260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUF19_06270	COG2188	Transcriptional regulator
HUF19_06280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUF19_06290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUF19_06315	COG1253	flavin adenine dinucleotide binding
HUF19_06330	COG0778	Nitroreductase
HUF19_06355	COG0429	hydrolase of the alpha beta-hydrolase fold
HUF19_06385	COG2030	dehydratase
HUF19_06415	COG1555	photosystem II stabilization
HUF19_06415	COG1596	polysaccharide export
HUF19_06445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUF19_06450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUF19_06455	COG0705	Rhomboid family
HUF19_06470	COG0308	aminopeptidase N
HUF19_06540	COG0488	(ABC) transporter
HUF19_06555	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUF19_06555	COG1024	Enoyl-CoA hydratase
HUF19_06560	COG0183	Belongs to the thiolase family
HUF19_06565	COG2860	membrane
HUF19_06570	COG0515	serine threonine protein kinase
HUF19_06570	COG2815	serine threonine protein kinase
HUF19_06575	COG2116	formate transmembrane transporter activity
HUF19_06600	COG3115	cell septum assembly
HUF19_06600	COG3115	cell septum assembly
HUF19_06605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUF19_06645	COG0714	Associated with various cellular activities
HUF19_06670	COG3130	regulation of translation
HUF19_06680	COG0004	ammonium transporteR
HUF19_06695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUF19_06700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUF19_06710	COG0307	riboflavin synthase, alpha
HUF19_06725	COG0784	Response regulator, receiver
HUF19_06725	COG5002	protein histidine kinase activity
HUF19_06740	COG1643	Atp-dependent helicase
HUF19_06760	COG0183	Belongs to the thiolase family
HUF19_06770	COG2814	Major facilitator Superfamily
HUF19_06775	COG0425	Belongs to the sulfur carrier protein TusA family
HUF19_06795	COG0795	lipopolysaccharide-transporting ATPase activity
HUF19_06800	COG0795	lipopolysaccharide-transporting ATPase activity
HUF19_06810	COG1575	Belongs to the MenA family. Type 1 subfamily
HUF19_06815	COG0259	pyridoxamine-phosphate oxidase activity
HUF19_06820	COG3001	Fructosamine kinase
HUF19_06845	COG0175	sulfate reduction
HUF19_06850	COG2945	thiolester hydrolase activity
HUF19_06855	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HUF19_06860	COG1309	transcriptional regulator
HUF19_06865	COG1012	belongs to the aldehyde dehydrogenase family
HUF19_06885	COG4175	Glycine betaine
HUF19_06895	COG0300	oxidoreductase activity
HUF19_06905	COG1477	protein flavinylation
HUF19_06935	COG5001	Diguanylate cyclase
HUF19_06935	COG3706	GGDEF domain
HUF19_06935	COG4251	negative regulation of phosphorylation
HUF19_06935	COG2203	Gaf domain
HUF19_06970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUF19_06975	COG0343	queuine tRNA-ribosyltransferase activity
HUF19_06980	COG1862	Preprotein translocase
HUF19_06995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HUF19_07000	COG1022	Amp-dependent synthetase and ligase
HUF19_07010	COG0583	DNA-binding transcription factor activity
HUF19_07015	COG0670	Belongs to the BI1 family
HUF19_07025	COG0386	Belongs to the glutathione peroxidase family
HUF19_07035	COG1902	pentaerythritol trinitrate reductase activity
HUF19_07040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUF19_07055	COG0525	valine-tRNA ligase activity
HUF19_07150	COG0525	valine-tRNA ligase activity
HUF19_07170	COG2226	methyltransferase
HUF19_07175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUF19_07180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HUF19_07225	COG0659	secondary active sulfate transmembrane transporter activity
HUF19_07235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUF19_07235	COG4191	Histidine kinase
HUF19_07250	COG0564	pseudouridine synthase activity
HUF19_07280	COG3323	Protein of unknown function (DUF1653)
HUF19_07280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUF19_07295	COG0494	nUDIX hydrolase
HUF19_07310	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUF19_07315	COG5001	Diguanylate cyclase
HUF19_07315	COG4251	negative regulation of phosphorylation
HUF19_07315	COG2203	Gaf domain
HUF19_07315	COG3706	GGDEF domain
HUF19_07340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUF19_07345	COG1054	Belongs to the UPF0176 family
HUF19_07355	COG4660	Part of a membrane complex involved in electron transport
HUF19_07360	COG4659	FMN binding
HUF19_07365	COG4658	electron transport chain
HUF19_07370	COG4656	Part of a membrane complex involved in electron transport
HUF19_07375	COG2878	Part of a membrane complex involved in electron transport
HUF19_07380	COG4657	Part of a membrane complex involved in electron transport
HUF19_07410	COG0601	transmembrane transport
HUF19_07415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUF19_07420	COG4172	Belongs to the ABC transporter superfamily
HUF19_07425	COG0489	protein tyrosine kinase activity
HUF19_07430	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUF19_07430	COG1902	pentaerythritol trinitrate reductase activity
HUF19_07440	COG4191	Histidine kinase
HUF19_07495	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUF19_07505	COG0741	lytic transglycosylase activity
HUF19_07510	COG0442	prolyl-tRNA aminoacylation
HUF19_07520	COG2818	Glycosylase
HUF19_07530	COG1285	pathogenesis
HUF19_07540	COG1131	(ABC) transporter
HUF19_07550	COG1309	transcriptional regulator
HUF19_07560	COG0456	acetyltransferase
HUF19_07570	COG1944	ATP diphosphatase activity
HUF19_07580	COG0243	molybdopterin cofactor binding
HUF19_07590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUF19_07595	COG2146	nitrite reductase [NAD(P)H] activity
HUF19_07600	COG2223	nitrite transmembrane transporter activity
HUF19_07605	COG2815	serine threonine protein kinase
HUF19_07605	COG0515	serine threonine protein kinase
HUF19_07615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUF19_07625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUF19_07635	COG1116	anion transmembrane transporter activity
HUF19_07645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUF19_07650	COG3707	response regulator
HUF19_07675	COG1032	radical SAM domain protein
HUF19_07715	COG0686	Belongs to the AlaDH PNT family
HUF19_07720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HUF19_07725	COG1074	ATP-dependent DNA helicase activity
HUF19_07730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUF19_07750	COG2268	Band 7 protein
HUF19_07770	COG0439	Biotin carboxylase
HUF19_07785	COG0671	phosphoesterase, PA-phosphatase related
HUF19_07805	COG0859	PFAM glycosyl transferase family 9
HUF19_07835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUF19_07840	COG1070	Carbohydrate kinase
HUF19_07845	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HUF19_07850	COG0835	chemotaxis
HUF19_07850	COG0784	Response regulator, receiver
HUF19_07855	COG0633	Ferredoxin
HUF19_07855	COG3217	Mosc domain protein beta barrel domain protein
HUF19_07865	COG2084	Dehydrogenase
HUF19_07880	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HUF19_07885	COG1053	succinate dehydrogenase
HUF19_07910	COG0045	succinate-CoA ligase (ADP-forming) activity
HUF19_07940	COG0589	response to stress
HUF19_07950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUF19_07960	COG0473	3-isopropylmalate dehydrogenase activity
HUF19_07980	COG0135	phosphoribosylanthranilate isomerase activity
HUF19_07985	COG0133	tryptophan synthase activity
HUF19_07990	COG0159	tryptophan synthase activity
HUF19_07995	COG0285	dihydrofolate synthase activity
HUF19_08005	COG1286	toxin biosynthetic process
HUF19_08020	COG0714	Associated with various cellular activities
HUF19_08055	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_08060	COG0667	Aldo Keto reductase
HUF19_08085	COG0493	'glutamate synthase
HUF19_08085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUF19_08090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUF19_08100	COG3101	peptidyl-lysine hydroxylation
HUF19_08130	COG5265	(ABC) transporter
HUF19_08135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUF19_08140	COG0824	Thioesterase
HUF19_08165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HUF19_08175	COG0784	Response regulator, receiver
HUF19_08175	COG2198	Histidine kinase
HUF19_08175	COG2205	protein histidine kinase activity
HUF19_08180	COG1067	ATP-dependent peptidase activity
HUF19_08200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUF19_08205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUF19_08210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUF19_08220	COG3100	YcgL domain-containing protein
HUF19_08225	COG2983	Belongs to the UPF0260 family
HUF19_08245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUF19_08325	COG0318	PFAM AMP-dependent synthetase and ligase
HUF19_08330	COG1643	Atp-dependent helicase
HUF19_08355	COG2853	Lipoprotein
HUF19_08375	COG0730	response to heat
HUF19_08390	COG0560	Phosphoserine phosphatase
HUF19_08430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HUF19_08445	COG0702	epimerase
HUF19_08455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUF19_08465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUF19_08470	COG0372	Belongs to the citrate synthase family
HUF19_08490	COG1530	ribonuclease E activity
HUF19_08495	COG0564	pseudouridine synthase activity
HUF19_08510	COG1399	metal-binding, possibly nucleic acid-binding protein
HUF19_08515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUF19_08520	COG0416	fatty acid biosynthetic process
HUF19_08530	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_08535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUF19_08540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUF19_08550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUF19_08555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUF19_08585	COG0811	peptide transport
HUF19_08590	COG0811	peptide transport
HUF19_08595	COG0848	biopolymer transport protein
HUF19_08610	COG0708	Exodeoxyribonuclease III
HUF19_08620	COG0301	tRNA thio-modification
HUF19_08620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUF19_08625	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_08675	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HUF19_08705	COG2165	general secretion pathway protein
HUF19_08775	COG2197	response regulator
HUF19_08785	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUF19_08800	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HUF19_08815	COG2920	part of a sulfur-relay system
HUF19_08825	COG0840	transmembrane signaling receptor activity
HUF19_08830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUF19_08830	COG1648	precorrin-2 dehydrogenase activity
HUF19_08835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUF19_08840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUF19_08845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUF19_08855	COG1674	ftsk spoiiie
HUF19_08860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HUF19_08865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HUF19_08870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUF19_08875	COG0542	response to heat
HUF19_08880	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUF19_08885	COG1278	Cold shock
HUF19_08910	COG2915	High frequency lysogenization protein hflD homolog
HUF19_08915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUF19_08940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUF19_08950	COG1477	protein flavinylation
HUF19_08955	COG0640	Transcriptional regulator
HUF19_08965	COG0679	Auxin Efflux Carrier
HUF19_08975	COG2813	Specifically methylates the guanine in position
HUF19_08980	COG1739	Uncharacterized protein family UPF0029
HUF19_09005	COG0826	peptidase U32
HUF19_09035	COG2062	phosphohistidine phosphatase, SixA
HUF19_09045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUF19_09055	COG0745	RESPONSE REGULATOR receiver
HUF19_09065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUF19_09065	COG0316	Belongs to the HesB IscA family
HUF19_09075	COG0534	Mate efflux family protein
HUF19_09080	COG0584	glycerophosphoryl diester phosphodiesterase
HUF19_09095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUF19_09095	COG4651	solute:proton antiporter activity
HUF19_09105	COG2378	regulation of single-species biofilm formation
HUF19_09110	COG0604	alcohol dehydrogenase
HUF19_09115	COG0616	signal peptide processing
HUF19_09135	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUF19_09145	COG0328	RNA-DNA hybrid ribonuclease activity
HUF19_09150	COG2226	methyltransferase
HUF19_09155	COG1388	LysM domain
HUF19_09155	COG0741	lytic transglycosylase activity
HUF19_09170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUF19_09185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUF19_09190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUF19_09195	COG0740	serine-type endopeptidase activity
HUF19_09200	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUF19_09220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUF19_09225	COG0215	cysteine-tRNA ligase activity
HUF19_09230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUF19_09235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUF19_09240	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUF19_09245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUF19_09250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUF19_09255	COG2835	tetraacyldisaccharide 4'-kinase activity
HUF19_09260	COG1663	tetraacyldisaccharide 4'-kinase activity
HUF19_09265	COG1132	(ABC) transporter
HUF19_09270	COG0848	biopolymer transport protein
HUF19_09275	COG0811	peptide transport
HUF19_09310	COG1199	ATP-dependent helicase activity
HUF19_09320	COG3409	Peptidoglycan-binding domain 1 protein
HUF19_09320	COG3267	Type II secretory pathway component ExeA
HUF19_09335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HUF19_09365	COG2850	peptidyl-arginine hydroxylation
HUF19_09380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HUF19_09390	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HUF19_09415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUF19_09435	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUF19_09435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUF19_09440	COG0842	Transport permease protein
HUF19_09445	COG1131	(ABC) transporter
HUF19_09480	COG5002	protein histidine kinase activity
HUF19_09480	COG2205	protein histidine kinase activity
HUF19_09480	COG0784	Response regulator, receiver
HUF19_09485	COG1846	Transcriptional regulator
HUF19_09490	COG0386	Belongs to the glutathione peroxidase family
HUF19_09495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUF19_09500	COG0436	Aminotransferase
HUF19_09510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUF19_09515	COG3383	formate dehydrogenase (NAD+) activity
HUF19_09520	COG1049	propionate catabolic process, 2-methylcitrate cycle
HUF19_09540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUF19_09565	COG2194	sulfuric ester hydrolase activity
HUF19_09575	COG0204	Acyl-transferase
HUF19_09580	COG1560	Kdo2-lipid A biosynthetic process
HUF19_09590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUF19_09605	COG1573	uracil-dna glycosylase
HUF19_09615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUF19_09645	COG0189	ligase activity
HUF19_09670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUF19_09675	COG1187	pseudouridine synthase activity
HUF19_09690	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HUF19_09700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUF19_09710	COG2837	iron assimilation
HUF19_09720	COG3920	Histidine kinase
HUF19_09725	COG0277	FAD linked oxidase domain protein
HUF19_09745	COG2186	Transcriptional regulator
HUF19_09760	COG0583	DNA-binding transcription factor activity
HUF19_09775	COG1942	4-Oxalocrotonate Tautomerase
HUF19_09780	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HUF19_09785	COG2095	MarC family integral membrane protein
HUF19_09795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUF19_09810	COG4977	sequence-specific DNA binding
HUF19_09845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUF19_09860	COG0367	asparagine synthase
HUF19_09875	COG0732	type I restriction modification DNA specificity domain
HUF19_09880	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUF19_09885	COG1715	Restriction endonuclease
HUF19_09920	COG4771	TonB-dependent receptor
HUF19_09930	COG3278	Belongs to the heme-copper respiratory oxidase family
HUF19_09945	COG2010	Cytochrome c
HUF19_09960	COG2217	Heavy metal translocating P-type atpase
HUF19_09970	COG4232	protein-disulfide reductase activity
HUF19_09975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUF19_09985	COG0037	tRNA processing
HUF19_09995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUF19_10025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUF19_10035	COG0271	Belongs to the BolA IbaG family
HUF19_10065	COG0640	Transcriptional regulator
HUF19_10110	COG0302	gtp cyclohydrolase
HUF19_10115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUF19_10125	COG3047	cAMP biosynthetic process
HUF19_10135	COG1960	acyl-CoA dehydrogenase activity
HUF19_10140	COG0318	PFAM AMP-dependent synthetase and ligase
HUF19_10175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUF19_10210	COG3318	Belongs to the UPF0149 family
HUF19_10210	COG3012	SEC-C Motif Domain Protein
HUF19_10220	COG0545	Peptidyl-prolyl cis-trans isomerase
HUF19_10245	COG0431	NADPH-dependent FMN reductase
HUF19_10250	COG0798	PFAM Bile acid sodium symporter
HUF19_10260	COG0640	Transcriptional regulator
HUF19_10265	COG3268	Saccharopine dehydrogenase
HUF19_10275	COG1278	Cold shock
HUF19_10280	COG0435	Glutathione S-transferase
HUF19_10285	COG2259	Doxx family
HUF19_10290	COG0583	DNA-binding transcription factor activity
HUF19_10295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUF19_10305	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUF19_10305	COG1902	pentaerythritol trinitrate reductase activity
HUF19_10320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUF19_10320	COG0519	Catalyzes the synthesis of GMP from XMP
HUF19_10370	COG1946	Acyl-CoA thioesterase
HUF19_10375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUF19_10380	COG0513	Belongs to the DEAD box helicase family
HUF19_10390	COG4191	Histidine kinase
HUF19_10390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUF19_10395	COG2203	Gaf domain
HUF19_10395	COG3706	GGDEF domain
HUF19_10395	COG5001	Diguanylate cyclase
HUF19_10395	COG4251	negative regulation of phosphorylation
HUF19_10400	COG0730	response to heat
HUF19_10410	COG0659	secondary active sulfate transmembrane transporter activity
HUF19_10415	COG2925	Exonuclease
HUF19_10420	COG2267	carboxylic ester hydrolase activity
HUF19_10475	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HUF19_10490	COG1805	sodium ion transport
HUF19_10495	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HUF19_10505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUF19_10525	COG1472	Belongs to the glycosyl hydrolase 3 family
HUF19_10540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUF19_10565	COG0326	Molecular chaperone. Has ATPase activity
HUF19_10570	COG0352	thiamine-phosphate diphosphorylase activity
HUF19_10575	COG2022	thiamine diphosphate biosynthetic process
HUF19_10590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUF19_10610	COG3437	response regulator, receiver
HUF19_10620	COG3706	GGDEF domain
HUF19_10635	COG0366	Alpha amylase catalytic
HUF19_10640	COG0077	Prephenate dehydratase
HUF19_10640	COG1605	Chorismate mutase
HUF19_10650	COG3769	mannosylglycerate metabolic process
HUF19_10655	COG1215	transferase activity, transferring glycosyl groups
HUF19_10665	COG1309	transcriptional regulator
HUF19_10670	COG0366	Alpha amylase catalytic
HUF19_10675	COG0800	Aldolase
HUF19_10680	COG0129	dihydroxy-acid dehydratase activity
HUF19_10690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUF19_10710	COG0545	Peptidyl-prolyl cis-trans isomerase
HUF19_10730	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUF19_10735	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUF19_10745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUF19_10755	COG0425	Belongs to the sulfur carrier protein TusA family
HUF19_10760	COG4783	chaperone-mediated protein folding
HUF19_10765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUF19_10780	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HUF19_10785	COG2885	chlorophyll binding
HUF19_10790	COG0823	Involved in the tonB-independent uptake of proteins
HUF19_10810	COG0824	Thioesterase
HUF19_10815	COG2255	four-way junction helicase activity
HUF19_10820	COG0632	four-way junction helicase activity
HUF19_10845	COG0583	DNA-binding transcription factor activity
HUF19_10865	COG3022	response to hydroperoxide
HUF19_10875	COG1960	acyl-CoA dehydrogenase activity
HUF19_10880	COG1960	acyl-CoA dehydrogenase activity
HUF19_10885	COG0318	PFAM AMP-dependent synthetase and ligase
HUF19_10895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUF19_10905	COG3122	Protein conserved in bacteria
HUF19_10920	COG0531	amino acid
HUF19_10930	COG0577	efflux transmembrane transporter activity
HUF19_10930	COG1136	(ABC) transporter
HUF19_10935	COG0577	efflux transmembrane transporter activity
HUF19_10935	COG1136	(ABC) transporter
HUF19_10940	COG1136	(ABC) transporter
HUF19_10940	COG0577	efflux transmembrane transporter activity
HUF19_10955	COG0776	regulation of translation
HUF19_10960	COG0072	phenylalanine-tRNA ligase activity
HUF19_10965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUF19_10970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUF19_10975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUF19_10980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUF19_10985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUF19_11010	COG0556	nucleotide-excision repair
HUF19_11015	COG0436	Aminotransferase
HUF19_11020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUF19_11035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUF19_11045	COG0717	Belongs to the dCTP deaminase family
HUF19_11065	COG0033	Phosphoglucomutase
HUF19_11070	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUF19_11085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUF19_11110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HUF19_11120	COG0463	Glycosyl transferase, family 2
HUF19_11125	COG0438	transferase activity, transferring glycosyl groups
HUF19_11140	COG2746	aminoglycoside 3-N-acetyltransferase activity
HUF19_11150	COG3321	synthase
HUF19_11150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUF19_11150	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_11150	COG4221	oxidoreductase activity
HUF19_11180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUF19_11195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUF19_11205	COG0284	orotidine-5'-phosphate decarboxylase activity
HUF19_11210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HUF19_11220	COG0776	regulation of translation
HUF19_11235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUF19_11240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUF19_11245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUF19_11255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUF19_11270	COG0402	S-adenosylhomocysteine deaminase activity
HUF19_11275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUF19_11285	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_11305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUF19_11315	COG0180	Tryptophanyl-tRNA synthetase
HUF19_11320	COG0180	Tryptophanyl-tRNA synthetase
HUF19_11325	COG0009	L-threonylcarbamoyladenylate synthase
HUF19_11330	COG0613	PHP domain protein
HUF19_11335	COG2350	Protein conserved in bacteria
HUF19_11340	COG4991	sh3 domain protein
HUF19_11350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUF19_11360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUF19_11360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HUF19_11380	COG3243	poly(R)-hydroxyalkanoic acid synthase
HUF19_11395	COG2814	Major facilitator Superfamily
HUF19_11400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUF19_11450	COG1295	ribonuclease BN
HUF19_11455	COG1393	Belongs to the ArsC family
HUF19_11480	COG0840	transmembrane signaling receptor activity
HUF19_11520	COG0443	Heat shock 70 kDa protein
HUF19_11525	COG1285	pathogenesis
HUF19_11530	COG4628	conserved protein (DUF2132)
HUF19_11555	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HUF19_11565	COG2252	PERMEase
HUF19_11570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUF19_11575	COG3081	Nucleoid-associated protein
HUF19_11600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HUF19_11620	COG0719	Fe-S assembly protein
HUF19_11625	COG0396	ATPase activity
HUF19_11630	COG0719	Fe-S assembly protein
HUF19_11635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUF19_11675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUF19_11695	COG1793	dna ligase
HUF19_11705	COG1091	dTDP-4-dehydrorhamnose reductase activity
HUF19_11765	COG2264	protein methyltransferase activity
HUF19_11785	COG0084	hydrolase, TatD family'
HUF19_11795	COG1192	Involved in chromosome partitioning
HUF19_11800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUF19_11810	COG2264	protein methyltransferase activity
HUF19_11820	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HUF19_11830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HUF19_11830	COG1918	ferrous iron import across plasma membrane
HUF19_11840	COG0306	phosphate transporter
HUF19_11855	COG4221	oxidoreductase activity
HUF19_11860	COG0400	carboxylic ester hydrolase activity
HUF19_11870	COG5001	Diguanylate cyclase
HUF19_11870	COG2203	Gaf domain
HUF19_11870	COG4251	negative regulation of phosphorylation
HUF19_11870	COG3706	GGDEF domain
HUF19_11875	COG5002	protein histidine kinase activity
HUF19_11875	COG0784	Response regulator, receiver
HUF19_11875	COG2205	protein histidine kinase activity
HUF19_11880	COG1393	Belongs to the ArsC family
HUF19_11885	COG2171	N-acyltransferase activity
HUF19_11890	COG1091	dTDP-4-dehydrorhamnose reductase activity
HUF19_11900	COG4953	penicillin-binding protein 1C
HUF19_11905	COG2373	Large extracellular alpha-helical protein
HUF19_11915	COG3706	GGDEF domain
HUF19_11920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUF19_11925	COG0346	lactoylglutathione lyase activity
HUF19_11930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUF19_11935	COG1278	Cold shock
HUF19_11940	COG3313	Fe-S protein
HUF19_11945	COG3622	Belongs to the hyi family
HUF19_11950	COG2084	Dehydrogenase
HUF19_11955	COG1639	'signal transduction protein
HUF19_11970	COG4067	protein conserved in archaea
HUF19_11970	COG0189	ligase activity
HUF19_11975	COG2193	ferroxidase activity
HUF19_11990	COG3706	GGDEF domain
HUF19_12010	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_12065	COG3738	Protein conserved in bacteria
HUF19_12075	COG1024	Enoyl-CoA hydratase
HUF19_12105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUF19_12115	COG0676	glucose-6-phosphate 1-epimerase activity
HUF19_12160	COG0436	Aminotransferase
HUF19_12175	COG1741	Belongs to the pirin family
HUF19_12185	COG0778	Nitroreductase
HUF19_12190	COG0583	DNA-binding transcription factor activity
HUF19_12200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUF19_12200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUF19_12220	COG0829	nickel cation binding
HUF19_12225	COG0831	urea catabolic process
HUF19_12230	COG0832	Belongs to the urease beta subunit family
HUF19_12235	COG0804	urea catabolic process
HUF19_12240	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HUF19_12245	COG0830	nickel cation binding
HUF19_12250	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUF19_12265	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUF19_12270	COG0471	metal ion transport
HUF19_12275	COG2703	oxygen carrier activity
HUF19_12285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUF19_12305	COG0633	Ferredoxin
HUF19_12305	COG0543	2 iron, 2 sulfur cluster binding
HUF19_12310	COG3706	GGDEF domain
HUF19_12320	COG2081	HI0933 family
HUF19_12330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUF19_12335	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUF19_12340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUF19_12345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUF19_12370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUF19_12380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUF19_12385	COG0233	cytoplasmic translational termination
HUF19_12390	COG0528	UMP kinase activity
HUF19_12395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUF19_12400	COG0052	Belongs to the universal ribosomal protein uS2 family
HUF19_12405	COG0024	Methionine aminopeptidase
HUF19_12410	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUF19_12415	COG1741	Belongs to the pirin family
HUF19_12420	COG0513	Belongs to the DEAD box helicase family
HUF19_12440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUF19_12445	COG0602	queuosine metabolic process
HUF19_12455	COG0583	DNA-binding transcription factor activity
HUF19_12460	COG3085	chromosome segregation
HUF19_12470	COG0189	ligase activity
HUF19_12485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUF19_12490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUF19_12500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUF19_12505	COG0840	transmembrane signaling receptor activity
HUF19_12510	COG0583	DNA-binding transcription factor activity
HUF19_12515	COG2205	protein histidine kinase activity
HUF19_12520	COG0745	RESPONSE REGULATOR receiver
HUF19_12525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUF19_12535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUF19_12545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUF19_12580	COG0835	chemotaxis
HUF19_12595	COG1192	Involved in chromosome partitioning
HUF19_12605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUF19_12610	COG2201	protein-glutamate methylesterase activity
HUF19_12615	COG0643	Histidine kinase
HUF19_12615	COG2198	Histidine kinase
HUF19_12615	COG0784	Response regulator, receiver
HUF19_12620	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HUF19_12645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUF19_12650	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUF19_12660	COG1987	bacterial-type flagellum assembly
HUF19_12700	COG0745	RESPONSE REGULATOR receiver
HUF19_12710	COG2201	protein-glutamate methylesterase activity
HUF19_12715	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HUF19_12725	COG0840	transmembrane signaling receptor activity
HUF19_12730	COG0835	chemotaxis
HUF19_12735	COG2198	Histidine kinase
HUF19_12735	COG0643	Histidine kinase
HUF19_12740	COG0745	RESPONSE REGULATOR receiver
HUF19_12775	COG1677	Flagellar hook-basal body complex protein FliE
HUF19_12800	COG2890	protein-(glutamine-N5) methyltransferase activity
HUF19_12805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUF19_12810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUF19_12860	COG2089	acid synthase
HUF19_12880	COG1083	cytidylyl-transferase
HUF19_12890	COG1086	Polysaccharide biosynthesis protein
HUF19_12915	COG1706	bacterial-type flagellum-dependent cell motility
HUF19_12920	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HUF19_12925	COG4786	Flagellar basal body rod
HUF19_12930	COG4786	Flagellar basal body rod
HUF19_12940	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HUF19_12945	COG1558	bacterial-type flagellum-dependent cell motility
HUF19_12950	COG1815	bacterial-type flagellum-dependent cell motility
HUF19_12960	COG0835	chemotaxis
HUF19_12960	COG0784	Response regulator, receiver
HUF19_13010	COG0393	Putative heavy-metal-binding
HUF19_13015	COG0393	Putative heavy-metal-binding
HUF19_13020	COG4783	chaperone-mediated protein folding
HUF19_13025	COG0492	ferredoxin-NADP+ reductase activity
HUF19_13065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUF19_13085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUF19_13085	COG4651	solute:proton antiporter activity
HUF19_13120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUF19_13125	COG0335	large ribosomal subunit rRNA binding
HUF19_13135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUF19_13140	COG0228	four-way junction DNA binding
HUF19_13150	COG0318	PFAM AMP-dependent synthetase and ligase
HUF19_13160	COG3848	Pyruvate phosphate dikinase
HUF19_13160	COG0574	Belongs to the PEP-utilizing enzyme family
HUF19_13235	COG0047	phosphoribosylformylglycinamidine synthase activity
HUF19_13235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUF19_13240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HUF19_13270	COG0023	Translation Initiation Factor
HUF19_13290	COG4191	Histidine kinase
HUF19_13295	COG0385	Bile acid
HUF19_13305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUF19_13345	COG0513	Belongs to the DEAD box helicase family
HUF19_13370	COG0625	glutathione transferase activity
HUF19_13380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUF19_13390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUF19_13395	COG4106	trans-aconitate 2-methyltransferase activity
HUF19_13400	COG1322	Protein conserved in bacteria
HUF19_13430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUF19_13460	COG1024	Enoyl-CoA hydratase
HUF19_13460	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUF19_13465	COG0183	Belongs to the thiolase family
HUF19_13470	COG1960	acyl-CoA dehydrogenase activity
HUF19_13475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUF19_13480	COG0789	Transcriptional regulator
HUF19_13495	COG2072	flavoprotein involved in K transport
HUF19_13515	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HUF19_13520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUF19_13535	COG0189	ligase activity
HUF19_13535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUF19_13545	COG1185	polyribonucleotide nucleotidyltransferase activity
HUF19_13550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUF19_13555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUF19_13560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUF19_13570	COG0195	Participates in both transcription termination and antitermination
HUF19_13575	COG0779	Required for maturation of 30S ribosomal subunits
HUF19_13590	COG0149	triose-phosphate isomerase activity
HUF19_13595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUF19_13600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUF19_13605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUF19_13610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HUF19_13630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUF19_13635	COG1607	acyl-coa hydrolase
HUF19_13640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUF19_13645	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUF19_13660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUF19_13665	COG0484	heat shock protein binding
HUF19_13670	COG0443	Heat shock 70 kDa protein
HUF19_13675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUF19_13680	COG0497	DNA recombination
HUF19_13695	COG2914	Belongs to the UPF0125 (RnfH) family
HUF19_13705	COG0733	neurotransmitter:sodium symporter activity
HUF19_13710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUF19_13755	COG3046	protein related to deoxyribodipyrimidine photolyase
HUF19_13765	COG0415	Belongs to the DNA photolyase family
HUF19_13770	COG0415	Belongs to the DNA photolyase family
HUF19_13780	COG0783	Belongs to the Dps family
HUF19_13795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUF19_13805	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUF19_13810	COG1492	cobalamin metabolic process
HUF19_13835	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUF19_13845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUF19_13860	COG1940	carbohydrate kinase activity
HUF19_13865	COG0789	Transcriptional regulator
HUF19_13885	COG1666	GTP binding
HUF19_13895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUF19_13900	COG2205	protein histidine kinase activity
HUF19_13900	COG4191	Histidine kinase
HUF19_13900	COG0745	RESPONSE REGULATOR receiver
HUF19_13915	COG2096	Adenosyltransferase
HUF19_13925	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUF19_13955	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HUF19_13970	COG0069	glutamate synthase activity
HUF19_13980	COG1090	epimerase
HUF19_13985	COG1960	acyl-CoA dehydrogenase activity
HUF19_13990	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HUF19_14000	COG3272	Protein of unknown function (DUF1722)
HUF19_14005	COG0789	Transcriptional regulator
HUF19_14010	COG0415	Belongs to the DNA photolyase family
HUF19_14025	COG4221	oxidoreductase activity
HUF19_14040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUF19_14065	COG0583	DNA-binding transcription factor activity
HUF19_14070	COG0745	RESPONSE REGULATOR receiver
HUF19_14075	COG2197	response regulator
HUF19_14090	COG1730	sister chromatid segregation
HUF19_14095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HUF19_14120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUF19_14130	COG0495	leucyl-tRNA aminoacylation
HUF19_14135	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HUF19_14155	COG3706	GGDEF domain
HUF19_14165	COG2207	Transcriptional regulator
HUF19_14170	COG1881	PFAM PEBP family protein
HUF19_14205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUF19_14210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HUF19_14235	COG1366	Belongs to the anti-sigma-factor antagonist family
HUF19_14240	COG0789	Transcriptional regulator
HUF19_14245	COG2813	Specifically methylates the guanine in position
HUF19_14255	COG2814	Major facilitator Superfamily
HUF19_14260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HUF19_14265	COG1765	OsmC-like protein
HUF19_14275	COG0784	Response regulator, receiver
HUF19_14275	COG3437	response regulator, receiver
HUF19_14280	COG0134	indole-3-glycerol-phosphate synthase activity
HUF19_14285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUF19_14290	COG0512	Glutamine amidotransferase of anthranilate synthase
HUF19_14325	COG1960	acyl-CoA dehydrogenase activity
HUF19_14330	COG1960	acyl-CoA dehydrogenase activity
HUF19_14345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUF19_14375	COG2267	carboxylic ester hydrolase activity
HUF19_14380	COG0183	Belongs to the thiolase family
HUF19_14385	COG0788	formyltetrahydrofolate deformylase activity
HUF19_14400	COG0004	ammonium transporteR
HUF19_14405	COG0517	IMP dehydrogenase activity
HUF19_14405	COG0516	GMP reductase activity
HUF19_14410	COG1611	Belongs to the LOG family
HUF19_14430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUF19_14450	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUF19_14485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUF19_14490	COG0424	maF-like protein
HUF19_14520	COG2827	Endonuclease containing a URI domain
HUF19_14525	COG1272	protein, Hemolysin III
HUF19_14540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HUF19_14545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUF19_14550	COG3178	'Phosphotransferase
HUF19_14555	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HUF19_14560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUF19_14570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUF19_14580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUF19_14585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUF19_14590	COG2766	serine protein kinase
HUF19_14595	COG2718	Belongs to the UPF0229 family
HUF19_14600	COG2719	SpoVR family
HUF19_14605	COG0697	spore germination
HUF19_14630	COG0617	tRNA 3'-terminal CCA addition
HUF19_14635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUF19_14635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUF19_14640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUF19_14645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUF19_14650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUF19_14655	COG1610	YqeY-like protein
HUF19_14660	COG0358	DNA primase activity
HUF19_14705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUF19_14710	COG2205	protein histidine kinase activity
HUF19_14715	COG0745	RESPONSE REGULATOR receiver
HUF19_14735	COG0625	glutathione transferase activity
HUF19_14810	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_14820	COG1063	alcohol dehydrogenase
HUF19_14825	COG5001	Diguanylate cyclase
HUF19_14855	COG0697	spore germination
HUF19_14860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUF19_14875	COG1671	Belongs to the UPF0178 family
HUF19_14885	COG2072	flavoprotein involved in K transport
HUF19_14920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUF19_14955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HUF19_14960	COG0527	aspartate kinase activity
HUF19_14965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUF19_14985	COG1252	NADH dehydrogenase
HUF19_14995	COG2137	regulation of response to DNA damage stimulus
HUF19_15000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUF19_15005	COG1546	Belongs to the CinA family
HUF19_15010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUF19_15035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUF19_15040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HUF19_15045	COG0585	pseudouridine synthase activity
HUF19_15050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUF19_15055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUF19_15060	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HUF19_15070	COG0504	CTP synthase activity
HUF19_15100	COG1279	arginine transmembrane transporter activity
HUF19_15115	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HUF19_15120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUF19_15140	COG0826	peptidase U32
HUF19_15170	COG0402	S-adenosylhomocysteine deaminase activity
HUF19_15175	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HUF19_15180	COG2351	hydroxyisourate hydrolase activity
HUF19_15190	COG4266	Belongs to the allantoicase family
HUF19_15200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUF19_15210	COG3845	ABC transporter
HUF19_15220	COG1079	Belongs to the binding-protein-dependent transport system permease family
HUF19_15230	COG1309	transcriptional regulator
HUF19_15235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUF19_15235	COG4191	Histidine kinase
HUF19_15245	COG5001	Diguanylate cyclase
HUF19_15245	COG4251	negative regulation of phosphorylation
HUF19_15245	COG3706	GGDEF domain
HUF19_15245	COG2203	Gaf domain
HUF19_15250	COG3447	MASE1 domain protein
HUF19_15250	COG5002	protein histidine kinase activity
HUF19_15250	COG5001	Diguanylate cyclase
HUF19_15255	COG0436	Aminotransferase
HUF19_15260	COG2166	iron-sulfur cluster assembly
HUF19_15265	COG1132	(ABC) transporter
HUF19_15275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUF19_15295	COG3590	peptidase
HUF19_15305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUF19_15310	COG1999	signal sequence binding
HUF19_15315	COG0109	protoheme IX farnesyltransferase activity
HUF19_15350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUF19_15355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUF19_15365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUF19_15385	COG0252	asparaginase activity
HUF19_15395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUF19_15400	COG3174	membrane
HUF19_15490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUF19_15495	COG0564	pseudouridine synthase activity
HUF19_15520	COG0681	Belongs to the peptidase S26 family
HUF19_15525	COG1238	metal cluster binding
HUF19_15550	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_15555	COG0583	DNA-binding transcription factor activity
HUF19_15575	COG2267	carboxylic ester hydrolase activity
HUF19_15585	COG4977	sequence-specific DNA binding
HUF19_15605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUF19_15605	COG2755	lipolytic protein G-D-S-L family
HUF19_15660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUF19_15665	COG4269	membrane
HUF19_15670	COG0501	Belongs to the peptidase M48B family
HUF19_15680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUF19_15685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUF19_15690	COG4558	Periplasmic binding protein
HUF19_15695	COG3720	iron ion transport
HUF19_15705	COG4206	TonB-dependent receptor
HUF19_15725	COG1597	lipid kinase activity
HUF19_15745	COG0523	cobalamin synthesis protein
HUF19_15750	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HUF19_15755	COG4181	ATPase activity
HUF19_15780	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HUF19_15785	COG3300	MHYT domain
HUF19_15785	COG5001	Diguanylate cyclase
HUF19_15805	COG0745	RESPONSE REGULATOR receiver
HUF19_15815	COG0517	IMP dehydrogenase activity
HUF19_15815	COG0516	GMP reductase activity
HUF19_15830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUF19_15845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUF19_15855	COG4890	Cyd operon protein YbgT
HUF19_15860	COG1294	oxidase, subunit
HUF19_15880	COG2199	diguanylate cyclase activity
HUF19_15910	COG0203	ribosomal protein L17
HUF19_15915	COG0202	RNA polymerase activity
HUF19_15920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUF19_15925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUF19_15930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUF19_15935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUF19_15945	COG0200	Binds to the 23S rRNA
HUF19_15950	COG1841	ribosomal large subunit assembly
HUF19_15955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUF19_15965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUF19_15970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUF19_15975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUF19_15980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUF19_15985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUF19_15990	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUF19_15995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUF19_16000	COG0255	Belongs to the universal ribosomal protein uL29 family
HUF19_16005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUF19_16010	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUF19_16015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUF19_16020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUF19_16025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUF19_16030	COG0089	rRNA binding
HUF19_16035	COG0088	Forms part of the polypeptide exit tunnel
HUF19_16040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUF19_16045	COG0051	transcription antitermination factor activity, RNA binding
HUF19_16050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUF19_16055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUF19_16060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUF19_16065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUF19_16070	COG0049	tRNA binding
HUF19_16075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUF19_16085	COG0085	RNA polymerase activity
HUF19_16090	COG0222	ribosome binding
HUF19_16095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUF19_16100	COG0081	regulation of translation
HUF19_16105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUF19_16125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUF19_16150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUF19_16155	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HUF19_16155	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HUF19_16165	COG0579	oxidoreductase
HUF19_16195	COG0318	PFAM AMP-dependent synthetase and ligase
HUF19_16220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUF19_16225	COG2508	Transcriptional regulator
HUF19_16230	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_16240	COG3040	lipid binding
HUF19_16245	COG0243	molybdopterin cofactor binding
HUF19_16255	COG3550	peptidyl-serine autophosphorylation
HUF19_16260	COG0028	Belongs to the TPP enzyme family
HUF19_16280	COG3154	lipid carrier protein
HUF19_16285	COG0826	peptidase U32
HUF19_16290	COG0826	peptidase U32
HUF19_16330	COG3256	nitric oxide reductase
HUF19_16335	COG2010	Cytochrome c
HUF19_16365	COG0348	domain, Protein
HUF19_16365	COG3901	Regulator of nitric oxide reductase transcription
HUF19_16370	COG4263	nitrous-oxide reductase activity
HUF19_16385	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HUF19_16395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUF19_16400	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUF19_16410	COG3604	Transcriptional regulator
HUF19_16415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUF19_16425	COG2197	response regulator
HUF19_16430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUF19_16435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUF19_16440	COG0746	molybdenum cofactor guanylyltransferase activity
HUF19_16445	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUF19_16450	COG0315	cyclic pyranopterin monophosphate synthase activity
HUF19_16455	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUF19_16460	COG0314	molybdopterin synthase activity
HUF19_16485	COG2223	nitrite transmembrane transporter activity
HUF19_16510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUF19_16515	COG2181	nitrate reductase activity
HUF19_16520	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HUF19_16525	COG1140	nitrate reductase beta subunit
HUF19_16530	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HUF19_16535	COG3850	Histidine kinase
HUF19_16680	COG1028	Short-chain dehydrogenase reductase Sdr
HUF19_16710	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUF19_16725	COG2329	Antibiotic biosynthesis monooxygenase
HUF19_16735	COG2226	methyltransferase
HUF19_16745	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUF19_16750	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HUF19_16755	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUF19_16760	COG0709	Synthesizes selenophosphate from selenide and ATP
HUF19_16785	COG2356	endonuclease I
HUF19_16795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUF19_16800	COG0746	molybdenum cofactor guanylyltransferase activity
HUF19_16805	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUF19_16810	COG0315	cyclic pyranopterin monophosphate synthase activity
HUF19_16815	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUF19_16820	COG0314	molybdopterin synthase activity
HUF19_16825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUF19_16845	COG0590	tRNA wobble adenosine to inosine editing
HUF19_16895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUF19_16910	COG1872	DUF167
HUF19_16920	COG0659	secondary active sulfate transmembrane transporter activity
HUF19_16935	COG2207	Transcriptional regulator
HUF19_16950	COG0531	amino acid
HUF19_16955	COG1846	Transcriptional regulator
HUF19_16985	COG2226	methyltransferase
HUF19_16995	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUF19_17025	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HUF19_17035	COG1960	acyl-CoA dehydrogenase activity
HUF19_17050	COG0471	metal ion transport
HUF19_17050	COG3273	potassium ion transport
HUF19_17065	COG1704	LemA family
HUF19_17080	COG0513	Belongs to the DEAD box helicase family
HUF19_17110	COG1011	Hydrolase
HUF19_17120	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUF19_17135	COG3072	Adenylate cyclase
HUF19_17150	COG1741	Belongs to the pirin family
HUF19_17180	COG3150	esterase
HUF19_17185	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUF19_17195	COG0494	nUDIX hydrolase
HUF19_17200	COG1538	Outer membrane efflux protein
HUF19_17205	COG1519	Transferase
HUF19_17210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUF19_17210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUF19_17215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUF19_17220	COG1560	Kdo2-lipid A biosynthetic process
HUF19_17230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUF19_17245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUF19_17245	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUF19_17255	COG0385	Bile acid
HUF19_17280	COG0840	transmembrane signaling receptor activity
HUF19_17285	COG0534	Mate efflux family protein
HUF19_17300	COG2840	Smr protein MutS2
HUF19_17305	COG0693	protein deglycase activity
HUF19_17325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUF19_17330	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUF19_17375	COG2818	Glycosylase
HUF19_17400	COG0248	Ppx GppA phosphatase
HUF19_17405	COG3118	belongs to the thioredoxin family
HUF19_17420	COG2177	Part of the ABC transporter FtsEX involved in
HUF19_17425	COG2884	Cell division ATP-binding protein ftsE
HUF19_17430	COG0552	protein localization to endoplasmic reticulum
HUF19_17440	COG0742	ribosomal rna small subunit methyltransferase
HUF19_17470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUF19_17475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUF19_17480	COG0405	Gamma-glutamyltransferase
HUF19_17485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUF19_17500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUF19_17505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUF19_17510	COG2003	Belongs to the UPF0758 family
HUF19_17515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUF19_17520	COG0756	dUTP diphosphatase activity
HUF19_17525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUF19_17530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUF19_17535	COG1309	transcriptional regulator
HUF19_17545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUF19_17555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUF19_17560	COG1561	YicC-like family, N-terminal region
HUF19_17570	COG1758	RNA polymerase activity
HUF19_17575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUF19_17590	COG0583	DNA-binding transcription factor activity
HUF19_17595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUF19_17610	COG1301	dicarboxylic acid transport
HUF19_17645	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUF19_17670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUF19_17700	COG5002	protein histidine kinase activity
HUF19_17715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUF19_17720	COG0581	inorganic phosphate transmembrane transporter activity
HUF19_17725	COG0573	inorganic phosphate transmembrane transporter activity
HUF19_17745	COG1607	acyl-coa hydrolase
HUF19_17750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUF19_17765	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUF19_17770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUF19_17775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HUF19_17780	COG0735	belongs to the Fur family
HUF19_17785	COG1121	(ABC) transporter
HUF19_17790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUF19_17795	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUF19_17825	COG1349	DNA-binding transcription factor activity
HUF19_17830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUF19_17870	COG1404	Belongs to the peptidase S8 family
HUF19_17875	COG1595	DNA-templated transcription, initiation
HUF19_17925	COG2203	Gaf domain
HUF19_17925	COG3706	GGDEF domain
HUF19_17925	COG4251	negative regulation of phosphorylation
HUF19_17925	COG5001	Diguanylate cyclase
HUF19_17940	COG1404	Belongs to the peptidase S8 family
HUF19_17955	COG0534	Mate efflux family protein
HUF19_17965	COG0583	DNA-binding transcription factor activity
HUF19_17970	COG3038	cytochrome b561
HUF19_17975	COG2353	YceI-like domain
HUF19_17990	COG5001	Diguanylate cyclase
HUF19_17990	COG3300	MHYT domain
HUF19_17995	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUF19_18000	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HUF19_18015	COG1024	Enoyl-CoA hydratase
HUF19_18015	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUF19_18035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUF19_18040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUF19_18045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUF19_18050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUF19_18060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUF19_18070	COG0356	it plays a direct role in the translocation of protons across the membrane
HUF19_18080	COG1475	DNA binding
HUF19_18085	COG1192	Involved in chromosome partitioning
HUF19_18095	COG0477	Major facilitator Superfamily
HUF19_18105	COG1024	Enoyl-CoA hydratase
HUF19_18110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUF19_18135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUF19_18140	COG1960	acyl-CoA dehydrogenase activity
HUF19_18180	COG0009	L-threonylcarbamoyladenylate synthase
HUF19_18185	COG3002	Belongs to the UPF0753 family
HUF19_18190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUF19_18195	COG0583	DNA-binding transcription factor activity
HUF19_18205	COG0445	tRNA wobble uridine modification
HUF19_18235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUF19_18240	COG0706	membrane insertase activity
HUF19_18250	COG0594	ribonuclease P activity