locus-tag	class	description
TOL_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TOL_0002	COG0592	DNA-directed DNA polymerase activity
TOL_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TOL_0010	COG1073	alpha beta
TOL_0011	COG2963	transposase activity
TOL_0012	COG2801	Transposase and inactivated derivatives
TOL_0029	COG3150	esterase
TOL_0036	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOL_0066	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TOL_0072	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TOL_0073	COG1349	DNA-binding transcription factor activity
TOL_0085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TOL_0115	COG0408	coproporphyrinogen oxidase activity
TOL_0116	COG0009	L-threonylcarbamoyladenylate synthase
TOL_0118	COG0758	DNA mediated transformation
TOL_0121	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TOL_0123	COG0569	domain protein
TOL_0126	COG0589	response to stress
TOL_0127	COG1595	DNA-templated transcription, initiation
TOL_0136	COG0552	protein localization to endoplasmic reticulum
TOL_0137	COG2884	Cell division ATP-binding protein ftsE
TOL_0138	COG2177	Part of the ABC transporter FtsEX involved in
TOL_0145	COG0573	inorganic phosphate transmembrane transporter activity
TOL_0147	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOL_0167	COG1301	dicarboxylic acid transport
TOL_0170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TOL_0175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TOL_0176	COG1758	RNA polymerase activity
TOL_0177	COG0194	GDP metabolic process
TOL_0192	COG2815	serine threonine protein kinase
TOL_0192	COG0515	serine threonine protein kinase
TOL_0209	COG0756	dUTP diphosphatase activity
TOL_0218	COG0405	Gamma-glutamyltransferase
TOL_0219	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL_0232	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOL_0233	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOL_0234	COG0537	adenosine 5'-monophosphoramidase activity
TOL_0235	COG0140	phosphoribosyl-ATP diphosphatase activity
TOL_0236	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TOL_0244	COG4771	TonB-dependent receptor
TOL_0251	COG0501	Belongs to the peptidase M48B family
TOL_0252	COG1704	LemA family
TOL_0265	COG0540	Belongs to the ATCase OTCase family
TOL_0266	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TOL_0276	COG2198	Histidine kinase
TOL_0276	COG0643	Histidine kinase
TOL_0277	COG2201	protein-glutamate methylesterase activity
TOL_0300	COG1176	ABC-type spermidine putrescine transport system, permease component I
TOL_0308	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TOL_0314	COG0316	Belongs to the HesB IscA family
TOL_0328	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOL_0330	COG0456	acetyltransferase
TOL_0332	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TOL_0338	COG0514	ATP-dependent DNA helicase (RecQ)
TOL_0350	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TOL_0357	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TOL_0402	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TOL_0424	COG4372	Transposase
TOL_0439	COG2137	regulation of response to DNA damage stimulus
TOL_0470	COG4382	Mu-like prophage protein Gp16
TOL_0480	COG0640	Transcriptional regulator
TOL_0482	COG4373	Mu-like prophage FluMu protein gp28
TOL_0483	COG4383	Mu-like prophage protein gp29
TOL_0485	COG2369	cell adhesion
TOL_0493	COG4397	Mu-like prophage major head subunit gpT
TOL_0499	COG4386	tail sheath protein
TOL_0526	COG1024	Enoyl-CoA hydratase
TOL_0530	COG5001	Diguanylate cyclase
TOL_0530	COG4251	negative regulation of phosphorylation
TOL_0530	COG2203	Gaf domain
TOL_0530	COG3706	GGDEF domain
TOL_0536	COG4372	Transposase
TOL_0552	COG1230	cation diffusion facilitator family transporter
TOL_0553	COG1742	UPF0060 membrane protein
TOL_0556	COG5002	protein histidine kinase activity
TOL_0559	COG2132	Multicopper oxidase
TOL_0563	COG2217	Heavy metal translocating P-type atpase
TOL_0584	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TOL_0585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TOL_0585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TOL_0592	COG2718	Belongs to the UPF0229 family
TOL_0596	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TOL_0598	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TOL_0599	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TOL_0600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOL_0603	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TOL_0624	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TOL_0627	COG2010	Cytochrome c
TOL_0638	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TOL_0639	COG1040	competence protein
TOL_0651	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOL_0655	COG1765	OsmC-like protein
TOL_0658	COG2813	Specifically methylates the guanine in position
TOL_0687	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TOL_0688	COG0237	dephospho-CoA kinase activity
TOL_0689	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TOL_0700	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TOL_0702	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TOL_0707	COG0508	dehydrogenase complex catalyzes the overall conversion of
TOL_0715	COG1960	acyl-CoA dehydrogenase activity
TOL_0716	COG0183	Belongs to the thiolase family
TOL_0732	COG4628	conserved protein (DUF2132)
TOL_0734	COG0025	NhaP-type Na H and K H
TOL_0778	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TOL_0779	COG2226	methyltransferase
TOL_0789	COG0745	RESPONSE REGULATOR receiver
TOL_0794	COG0275	rRNA processing
TOL_0797	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TOL_0798	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TOL_0799	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TOL_0801	COG0772	Belongs to the SEDS family
TOL_0802	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TOL_0803	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOL_0804	COG1181	Belongs to the D-alanine--D-alanine ligase family
TOL_0805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TOL_0810	COG0653	protein targeting
TOL_0815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TOL_0816	COG4535	Mg2 and Co2 transporter CorC
TOL_0818	COG1702	phosphate starvation-inducible protein PhoH
TOL_0827	COG0193	aminoacyl-tRNA hydrolase activity
TOL_0831	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TOL_0832	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TOL_0835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TOL_0836	COG2890	protein-(glutamine-N5) methyltransferase activity
TOL_0841	COG0792	nuclease activity
TOL_0842	COG3107	peptidoglycan biosynthetic process
TOL_0869	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TOL_0899	COG0811	peptide transport
TOL_0900	COG0811	peptide transport
TOL_0901	COG0848	biopolymer transport protein
TOL_0902	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
TOL_0918	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOL_0921	COG0571	ribonuclease III activity
TOL_0922	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TOL_0923	COG1381	Involved in DNA repair and RecF pathway recombination
TOL_0925	COG0736	holo-[acyl-carrier-protein] synthase activity
TOL_0929	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TOL_0937	COG1968	undecaprenyl-diphosphatase activity
TOL_0949	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TOL_0952	COG0124	histidyl-tRNA synthetase
TOL_0964	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TOL_0965	COG0830	nickel cation binding
TOL_0966	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TOL_0967	COG0804	urea catabolic process
TOL_0968	COG0832	Belongs to the urease beta subunit family
TOL_0969	COG0831	urea catabolic process
TOL_0976	COG0432	Pfam Uncharacterised protein family UPF0047
TOL_0978	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TOL_0982	COG4804	nuclease activity
TOL_1010	COG2264	protein methyltransferase activity
TOL_1013	COG0084	hydrolase, TatD family'
TOL_1025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TOL_1034	COG0300	oxidoreductase activity
TOL_1037	COG1025	Belongs to the peptidase M16 family
TOL_1056	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TOL_1073	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TOL_1077	COG1138	Cytochrome C-type biogenesis protein
TOL_1078	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TOL_1100	COG2199	diguanylate cyclase activity
TOL_1100	COG2202	Pas domain
TOL_1100	COG2200	EAL domain
TOL_1136	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TOL_1137	COG0705	Rhomboid family
TOL_1140	COG0308	aminopeptidase N
TOL_1188	COG2304	oxidoreductase activity
TOL_1191	COG0714	Associated with various cellular activities
TOL_1209	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TOL_1224	COG4115	mRNA cleavage
TOL_1232	COG3264	Mechanosensitive ion channel
TOL_1232	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
TOL_1247	COG2925	Exonuclease
TOL_1255	COG0513	Belongs to the DEAD box helicase family
TOL_1260	COG0739	heme binding
TOL_1287	COG4372	Transposase
TOL_1302	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TOL_1323	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOL_1338	COG2801	Transposase and inactivated derivatives
TOL_1346	COG2226	methyltransferase
TOL_1347	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TOL_1373	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TOL_1399	COG4659	FMN binding
TOL_1400	COG4658	electron transport chain
TOL_1401	COG4656	Part of a membrane complex involved in electron transport
TOL_1402	COG2878	Part of a membrane complex involved in electron transport
TOL_1406	COG0601	transmembrane transport
TOL_1407	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOL_1408	COG4172	Belongs to the ABC transporter superfamily
TOL_1427	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TOL_1428	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TOL_1436	COG2818	Glycosylase
TOL_1448	COG2146	nitrite reductase [NAD(P)H] activity
TOL_1454	COG1116	anion transmembrane transporter activity
TOL_1472	COG1074	ATP-dependent DNA helicase activity
TOL_1473	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOL_1491	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TOL_1492	COG1053	succinate dehydrogenase
TOL_1497	COG0045	succinate-CoA ligase (ADP-forming) activity
TOL_1509	COG2801	Transposase and inactivated derivatives
TOL_1521	COG1012	belongs to the aldehyde dehydrogenase family
TOL_1522	COG0006	proline dipeptidase activity
TOL_1523	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TOL_1525	COG0280	phosphate acetyltransferase
TOL_1526	COG0589	response to stress
TOL_1537	COG0133	tryptophan synthase activity
TOL_1539	COG0285	dihydrofolate synthase activity
TOL_1551	COG0667	Aldo Keto reductase
TOL_1563	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TOL_1573	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOL_1574	COG0824	Thioesterase
TOL_1586	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TOL_1587	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TOL_1589	COG3100	YcgL domain-containing protein
TOL_1590	COG2983	Belongs to the UPF0260 family
TOL_1612	COG3220	belongs to the UPF0276 family
TOL_1635	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TOL_1636	COG0372	Belongs to the citrate synthase family
TOL_1642	COG0546	phosphoglycolate phosphatase activity
TOL_1643	COG0616	signal peptide processing
TOL_1645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TOL_1646	COG0416	fatty acid biosynthetic process
TOL_1648	COG1028	Short-chain dehydrogenase reductase Sdr
TOL_1651	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TOL_1652	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TOL_1657	COG0666	response to abiotic stimulus
TOL_1664	COG0811	peptide transport
TOL_1665	COG0811	peptide transport
TOL_1666	COG0848	biopolymer transport protein
TOL_1677	COG1028	Short-chain dehydrogenase reductase Sdr
TOL_1703	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL_1709	COG5002	protein histidine kinase activity
TOL_1722	COG2217	Heavy metal translocating P-type atpase
TOL_1729	COG0058	SHG alpha-glucan phosphorylase activity
TOL_1743	COG0431	NADPH-dependent FMN reductase
TOL_1751	COG2326	polyphosphate kinase activity
TOL_1757	COG3156	type II secretion system protein K
TOL_1774	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOL_1775	COG0322	excinuclease ABC activity
TOL_1776	COG2197	response regulator
TOL_1781	COG2923	Belongs to the DsrF TusC family
TOL_1783	COG2920	part of a sulfur-relay system
TOL_1786	COG1648	precorrin-2 dehydrogenase activity
TOL_1786	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOL_1787	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TOL_1788	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TOL_1789	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TOL_1790	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TOL_1793	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TOL_1802	COG2915	High frequency lysogenization protein hflD homolog
TOL_1823	COG2062	phosphohistidine phosphatase, SixA
TOL_1825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TOL_1827	COG0745	RESPONSE REGULATOR receiver
TOL_1831	COG0534	Mate efflux family protein
TOL_1832	COG0584	glycerophosphoryl diester phosphodiesterase
TOL_1836	COG0604	alcohol dehydrogenase
TOL_1843	COG0328	RNA-DNA hybrid ribonuclease activity
TOL_1845	COG0741	lytic transglycosylase activity
TOL_1845	COG1388	LysM domain
TOL_1875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TOL_1876	COG2835	tetraacyldisaccharide 4'-kinase activity
TOL_1877	COG1663	tetraacyldisaccharide 4'-kinase activity
TOL_1878	COG1132	(ABC) transporter
TOL_1932	COG2801	Transposase and inactivated derivatives
TOL_1939	COG0842	Transport permease protein
TOL_1948	COG1846	Transcriptional regulator
TOL_1953	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOL_1954	COG3383	formate dehydrogenase (NAD+) activity
TOL_2014	COG0484	heat shock protein binding
TOL_2032	COG0302	gtp cyclohydrolase
TOL_2033	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TOL_2048	COG3012	SEC-C Motif Domain Protein
TOL_2053	COG0798	PFAM Bile acid sodium symporter
TOL_2075	COG1805	sodium ion transport
TOL_2083	COG1472	Belongs to the glycosyl hydrolase 3 family
TOL_2084	COG1376	ErfK ybiS ycfS ynhG family protein
TOL_2093	COG2022	thiamine diphosphate biosynthetic process
TOL_2100	COG3437	response regulator, receiver
TOL_2107	COG3769	mannosylglycerate metabolic process
TOL_2112	COG0800	Aldolase
TOL_2114	COG0363	glucosamine-6-phosphate deaminase activity
TOL_2130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TOL_2133	COG4783	chaperone-mediated protein folding
TOL_2138	COG2885	chlorophyll binding
TOL_2139	COG0823	Involved in the tonB-independent uptake of proteins
TOL_2143	COG0824	Thioesterase
TOL_2144	COG2255	four-way junction helicase activity
TOL_2156	COG1960	acyl-CoA dehydrogenase activity
TOL_2160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TOL_2166	COG1136	(ABC) transporter
TOL_2166	COG0577	efflux transmembrane transporter activity
TOL_2167	COG0577	efflux transmembrane transporter activity
TOL_2167	COG1136	(ABC) transporter
TOL_2168	COG1136	(ABC) transporter
TOL_2168	COG0577	efflux transmembrane transporter activity
TOL_2174	COG1397	ADP-ribosylglycohydrolase
TOL_2183	COG0776	regulation of translation
TOL_2184	COG0072	phenylalanine-tRNA ligase activity
TOL_2187	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TOL_2203	COG1045	serine acetyltransferase
TOL_2211	COG1045	serine acetyltransferase
TOL_2217	COG3639	organic phosphonate transmembrane transporter activity
TOL_2219	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TOL_2220	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TOL_2232	COG1518	maintenance of DNA repeat elements
TOL_2261	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TOL_2263	COG0717	Belongs to the dCTP deaminase family
TOL_2264	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TOL_2269	COG2801	Transposase and inactivated derivatives
TOL_2270	COG4372	Transposase
TOL_2273	COG0438	transferase activity, transferring glycosyl groups
TOL_2285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TOL_2286	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TOL_2289	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TOL_2293	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOL_2298	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TOL_2300	COG0180	Tryptophanyl-tRNA synthetase
TOL_2301	COG0180	Tryptophanyl-tRNA synthetase
TOL_2302	COG0009	L-threonylcarbamoyladenylate synthase
TOL_2305	COG2350	Protein conserved in bacteria
TOL_2325	COG1295	ribonuclease BN
TOL_2335	COG0443	Heat shock 70 kDa protein
TOL_2349	COG0719	Fe-S assembly protein
TOL_2350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TOL_2359	COG2171	N-acyltransferase activity
TOL_2410	COG0864	Transcriptional regulator
TOL_2432	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TOL_2433	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL_2434	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL_2435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TOL_2442	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TOL_2443	COG0233	cytoplasmic translational termination
TOL_2444	COG0528	UMP kinase activity
TOL_2448	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TOL_2464	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TOL_2468	COG0583	DNA-binding transcription factor activity
TOL_2473	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TOL_2474	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TOL_2485	COG2201	protein-glutamate methylesterase activity
TOL_2486	COG2198	Histidine kinase
TOL_2486	COG0643	Histidine kinase
TOL_2487	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
TOL_2490	COG0455	bacterial-type flagellum organization
TOL_2494	COG1684	flagellar biosynthetic protein fliR
TOL_2495	COG1987	bacterial-type flagellum assembly
TOL_2505	COG2201	protein-glutamate methylesterase activity
TOL_2506	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TOL_2508	COG0840	transmembrane signaling receptor activity
TOL_2509	COG0835	chemotaxis
TOL_2510	COG0643	Histidine kinase
TOL_2510	COG2198	Histidine kinase
TOL_2519	COG2204	response regulator
TOL_2532	COG0489	protein tyrosine kinase activity
TOL_2533	COG1596	polysaccharide export
TOL_2541	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TOL_2563	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TOL_2563	COG0517	IMP dehydrogenase activity
TOL_2565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOL_2566	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TOL_2567	COG0297	glycogen (starch) synthase activity
TOL_2568	COG0110	maltose O-acetyltransferase activity
TOL_2579	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TOL_2587	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TOL_2588	COG4786	Flagellar basal body rod
TOL_2589	COG4787	bacterial-type flagellum-dependent cell motility
TOL_2591	COG1749	Flagellar hook protein flgE
TOL_2592	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TOL_2593	COG1558	bacterial-type flagellum-dependent cell motility
TOL_2597	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
TOL_2611	COG0393	Putative heavy-metal-binding
TOL_2618	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TOL_2620	COG4651	solute:proton antiporter activity
TOL_2620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TOL_2623	COG0564	pseudouridine synthase activity
TOL_2626	COG0336	Belongs to the RNA methyltransferase TrmD family
TOL_2627	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TOL_2628	COG0228	four-way junction DNA binding
TOL_2636	COG4372	Transposase
TOL_2667	COG0625	glutathione transferase activity
TOL_2677	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL_2685	COG0519	Catalyzes the synthesis of GMP from XMP
TOL_2685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TOL_2694	COG4106	trans-aconitate 2-methyltransferase activity
TOL_2696	COG1322	Protein conserved in bacteria
TOL_2698	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TOL_2714	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TOL_2715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TOL_2717	COG0195	Participates in both transcription termination and antitermination
TOL_2722	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOL_2732	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TOL_2733	COG0505	Belongs to the CarA family
TOL_2760	COG0811	peptide transport
TOL_2761	COG0848	biopolymer transport protein
TOL_2766	COG3128	pkhd-type hydroxylase
TOL_2771	COG0824	Thioesterase
TOL_2772	COG1454	alcohol dehydrogenase
TOL_2776	COG3046	protein related to deoxyribodipyrimidine photolyase
TOL_2778	COG0415	Belongs to the DNA photolyase family
TOL_2801	COG4372	Transposase
TOL_2803	COG1090	epimerase
TOL_2808	COG0789	Transcriptional regulator
TOL_2809	COG0415	Belongs to the DNA photolyase family
TOL_2812	COG0300	oxidoreductase activity
TOL_2815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TOL_2824	COG0587	DNA-directed DNA polymerase activity
TOL_2826	COG2211	Major facilitator Superfamily
TOL_2829	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TOL_2830	COG5002	protein histidine kinase activity
TOL_2846	COG2863	cytochrome
TOL_2851	COG2264	protein methyltransferase activity
TOL_2855	COG0138	bifunctional purine biosynthesis protein purh
TOL_2856	COG0151	Belongs to the GarS family
TOL_2877	COG1047	Peptidyl-prolyl cis-trans
TOL_2878	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TOL_2879	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TOL_2881	COG0728	peptidoglycan biosynthetic process
TOL_2884	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TOL_2885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOL_2894	COG0321	lipoyl(octanoyl) transferase activity
TOL_2903	COG0586	Pfam SNARE associated Golgi protein
TOL_2910	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TOL_2911	COG0768	penicillin binding
TOL_2912	COG0772	Belongs to the SEDS family
TOL_2913	COG2951	lytic endotransglycosylase activity
TOL_2914	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TOL_2935	COG0671	phosphoesterase, PA-phosphatase related
TOL_2938	COG0850	regulation of cytokinetic process
TOL_2939	COG2894	cell division
TOL_2940	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TOL_2960	COG4796	Type ii and iii secretion system protein
TOL_2977	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOL_2979	COG4942	peptidase
TOL_2981	COG2861	carbohydrate metabolic process
TOL_2985	COG0598	Magnesium transport protein CorA
TOL_2989	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TOL_2994	COG1489	DNA binding
TOL_2997	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOL_2999	COG4191	Histidine kinase
TOL_3002	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TOL_3003	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TOL_3004	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TOL_3008	COG0235	Class ii aldolase
TOL_3009	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TOL_3010	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TOL_3017	COG3153	acetyltransferase
TOL_3017	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL_3020	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TOL_3027	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TOL_3028	COG0860	N-Acetylmuramoyl-L-alanine amidase
TOL_3029	COG0802	atpase or kinase
TOL_3038	COG0688	phosphatidylethanolamine metabolic process
TOL_3039	COG0583	DNA-binding transcription factor activity
TOL_3062	COG0585	pseudouridine synthase activity
TOL_3063	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TOL_3064	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TOL_3077	COG0504	CTP synthase activity
TOL_3080	COG2354	Protein conserved in bacteria
TOL_3088	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TOL_3089	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TOL_3092	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TOL_3093	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TOL_3098	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TOL_3099	COG1137	ATPase activity
TOL_3103	COG1660	Displays ATPase and GTPase activities
TOL_3104	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOL_3106	COG3028	Belongs to the UPF0307 family
TOL_3109	COG1530	ribonuclease E activity
TOL_3110	COG0424	maF-like protein
TOL_3111	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TOL_3115	COG0154	amidase activity
TOL_3121	COG4372	Transposase
TOL_3132	COG0179	Fumarylacetoacetate (FAA) hydrolase
TOL_3143	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOL_3143	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOL_3146	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TOL_3160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOL_3181	COG0546	phosphoglycolate phosphatase activity
TOL_3199	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOL_3207	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL_3211	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TOL_3215	COG4191	Histidine kinase
TOL_3215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOL_3217	COG0142	geranyltranstransferase activity
TOL_3219	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TOL_3220	COG1360	Flagellar Motor Protein
TOL_3222	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TOL_3226	COG2212	antiporter activity
TOL_3228	COG0651	ATP synthesis coupled electron transport
TOL_3229	COG1006	Multisubunit Na H antiporter MnhC subunit
TOL_3236	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TOL_3237	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TOL_3247	COG1119	ATPase activity
TOL_3248	COG0537	adenosine 5'-monophosphoramidase activity
TOL_3249	COG0745	RESPONSE REGULATOR receiver
TOL_3249	COG3706	GGDEF domain
TOL_3263	COG2166	iron-sulfur cluster assembly
TOL_3278	COG0402	S-adenosylhomocysteine deaminase activity
TOL_3280	COG2351	hydroxyisourate hydrolase activity
TOL_3282	COG4266	Belongs to the allantoicase family
TOL_3284	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TOL_3289	COG1957	nucleoside hydrolase
TOL_3293	COG0811	peptide transport
TOL_3294	COG0811	peptide transport
TOL_3295	COG0848	biopolymer transport protein
TOL_3308	COG2315	Protein conserved in bacteria
TOL_3320	COG2801	Transposase and inactivated derivatives
TOL_3323	COG4372	Transposase
TOL_3344	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TOL_3349	COG0716	FMN binding
TOL_3359	COG2205	protein histidine kinase activity
TOL_3375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOL_3398	COG1061	Type III restriction enzyme res subunit
TOL_3400	COG0534	Mate efflux family protein
TOL_3412	COG4890	Cyd operon protein YbgT
TOL_3413	COG1294	oxidase, subunit
TOL_3425	COG0202	RNA polymerase activity
TOL_3426	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TOL_3427	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TOL_3429	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TOL_3431	COG0200	Binds to the 23S rRNA
TOL_3432	COG1841	ribosomal large subunit assembly
TOL_3433	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TOL_3435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TOL_3436	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TOL_3437	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TOL_3438	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TOL_3439	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TOL_3440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TOL_3441	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TOL_3442	COG0255	Belongs to the universal ribosomal protein uL29 family
TOL_3444	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TOL_3445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TOL_3446	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TOL_3447	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TOL_3448	COG0089	rRNA binding
TOL_3449	COG0088	Forms part of the polypeptide exit tunnel
TOL_3453	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOL_3457	COG0085	RNA polymerase activity
TOL_3459	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TOL_3460	COG0081	regulation of translation
TOL_3461	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TOL_3472	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TOL_3474	COG4953	penicillin-binding protein 1C
TOL_3490	COG4372	Transposase
TOL_3493	COG5001	Diguanylate cyclase
TOL_3493	COG2203	Gaf domain
TOL_3493	COG3706	GGDEF domain
TOL_3493	COG4251	negative regulation of phosphorylation
TOL_3496	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TOL_3499	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TOL_3513	COG1404	Belongs to the peptidase S8 family
TOL_3520	COG0746	molybdenum cofactor guanylyltransferase activity
TOL_3521	COG0521	Mo-molybdopterin cofactor biosynthetic process
TOL_3522	COG0315	cyclic pyranopterin monophosphate synthase activity
TOL_3523	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TOL_3530	COG1872	DUF167
TOL_3531	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TOL_3532	COG2813	Specifically methylates the guanine in position
TOL_3532	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TOL_3534	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TOL_3536	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOL_3539	COG0527	aspartate kinase activity
TOL_3540	COG1917	Cupin 2, conserved barrel domain protein
TOL_3541	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TOL_3555	COG0204	Acyl-transferase
TOL_3569	COG0347	Belongs to the P(II) protein family
TOL_3573	COG0411	ABC transporter
TOL_3577	COG1802	Transcriptional regulator
TOL_3602	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
TOL_3610	COG0006	proline dipeptidase activity
TOL_3615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TOL_3625	COG0745	RESPONSE REGULATOR receiver
TOL_3626	COG0628	permease
TOL_3629	COG1346	cytolysis
TOL_3633	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TOL_3634	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TOL_3646	COG2015	COG2015, Alkyl sulfatase and related hydrolases
TOL_3648	COG2832	Protein of unknown function (DUF454)
TOL_3662	COG1234	tRNA 3'-trailer cleavage
TOL_3673	COG2959	enzyme of heme biosynthesis
TOL_3683	COG2307	Protein conserved in bacteria
TOL_3683	COG2308	Evidence 4 Homologs of previously reported genes of
TOL_3695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TOL_3697	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TOL_3699	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TOL_3704	COG1475	DNA binding
TOL_3705	COG1192	Involved in chromosome partitioning
TOL_3712	COG0745	RESPONSE REGULATOR receiver
TOL_3713	COG2205	protein histidine kinase activity
TOL_3715	COG3002	Belongs to the UPF0753 family