locus-tag	class	description
R615_00005	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
R615_00010	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
R615_00015	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
R615_00040	ENOG4107XM9	(LipO)protein
R615_00055	ENOG4105D8X	mechanosensitive ion channel
R615_00070	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
R615_00080	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
R615_00090	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
R615_00115	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
R615_00130	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
R615_00135	ENOG4105IPS	esterase
R615_00140	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
R615_00145	ENOG4108SX3	cytoplasmic protein
R615_00150	ENOG41087AY	ADP-Ribose pyrophosphatase
R615_00155	ENOG4105DFG	type I secretion outer membrane protein
R615_00160	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
R615_00170	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
R615_00175	ENOG4105D1S	lipid A biosynthesis
R615_00180	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
R615_00185	ENOG4105C58	cytochrome c oxidase accessory protein ccog
R615_00195	ENOG4105TMB	Formate nitrite transporter
R615_00200	ENOG4105C1G	acyl-Coa dehydrogenase
R615_00205	ENOG4105CHR	reductase
R615_00230	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
R615_00235	ENOG4105C0P	Mg chelatase subunit ChlI
R615_00260	ENOG4105C4R	Atp-dependent dna helicase
R615_00290	ENOG4105J8Z	peptidase S8 and S53, subtilisin, kexin, sedolisin
R615_00300	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
R615_00310	ENOG4107PBV	potassium channel
R615_00345	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
R615_00350	ENOG410804X	Transcriptional regulator
R615_00355	ENOG4105BZU	Histidine kinase
R615_00365	ENOG4108Z33	Thiol disulfide Interchange Protein
R615_00370	ENOG4106RE7	Cytochrome
R615_00375	ENOG4105MPD	Cytochrome
R615_00380	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
R615_00400	ENOG4105C2M	dna polymerase I
R615_00410	ENOG4105CUV	Homoserine Kinase
R615_00425	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
R615_00430	ENOG4108KN0	Choline kinase
R615_00435	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
R615_00445	ENOG4108ESX	Receptor
R615_00450	ENOG4105D0M	Protease HtpX homolog
R615_00455	ENOG4105BZU	Histidine kinase
R615_00505	ENOG4105DGW	oligopeptidase A
R615_00510	ENOG4108Z0R	Transferase
R615_00550	ENOG4106IUH	DTW domain containing protein
R615_00560	ENOG4105CDY	transcriptional regulatory protein
R615_00580	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
R615_00590	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
R615_00595	ENOG4105C79	DNA protecting protein DprA
R615_00605	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
R615_00610	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
R615_00615	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
R615_00620	ENOG4105C1A	potassium transporter peripheral membrane
R615_00625	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
R615_00630	ENOG4105CHH	sulfate transporter
R615_00640	ENOG4108WQI	RNA Polymerase
R615_00665	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
R615_00675	ENOG4106H78	methyltransferase
R615_00685	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
R615_00690	ENOG4105CAK	Cell division ATP-binding protein ftsE
R615_00695	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
R615_00700	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
R615_00705	ENOG4105NAU	thioesterase Superfamily protein
R615_00710	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
R615_00725	ENOG4105C8U	phosphate abc transporter
R615_00735	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
R615_00740	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
R615_00745	ENOG4105QMY	Porin Gram-negative type
R615_00750	ENOG4105BZU	Histidine kinase
R615_00755	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
R615_00780	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
R615_00790	ENOG4108VYJ	response regulator receiver protein
R615_00795	ENOG4105BZU	Histidine kinase
R615_00800	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
R615_00805	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
R615_00810	ENOG4105VCQ	rubredoxin
R615_00815	ENOG4107QZF	nitrite reductase NADPH large subunit
R615_00820	ENOG4105NYX	DNA-binding protein
R615_00850	ENOG4105CB5	ATP-dependent DNA helicase recG
R615_00855	ENOG4105C5Q	Transcriptional regulator
R615_00870	ENOG4105KME	endoribonuclease L-psp
R615_00875	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
R615_00880	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
R615_00885	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
R615_00890	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
R615_00895	ENOG4105DSJ	YicC domain protein
R615_00900	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
R615_00910	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
R615_00920	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
R615_00925	ENOG4105CAS	nag kinase
R615_00930	ENOG4107QKV	phosphomannomutase
R615_00935	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
R615_00945	ENOG4105W5Q	DNA repair protein (RadC
R615_00950	ENOG4105KDC	50s ribosomal protein l28
R615_00955	ENOG4105W0E	50S ribosomal protein L33
R615_00970	ENOG4107S90	membrAne
R615_00975	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
R615_00980	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
R615_01000	ENOG4107RGH	Aldehyde dehydrogenase
R615_01045	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
R615_01050	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
R615_01055	ENOG4107YU2	histidine triad (hIT) protein
R615_01060	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
R615_01065	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
R615_01070	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
R615_01080	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
R615_01100	ENOG4105BZU	Histidine kinase
R615_01110	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
R615_01115	ENOG4108ZG0	Ompa motb domain protein
R615_01125	ENOG4108UJV	acyl-CoA thioesterase i
R615_01130	ENOG4108I0Y	(ABC) transporter
R615_01135	ENOG4105CV6	ABC transporter, permease
R615_01140	ENOG4105D0M	Protease HtpX homolog
R615_01145	ENOG4108V0P	LemA family
R615_01155	ENOG410689M	(LipO)protein
R615_01160	ENOG4105C1J	atp-dependent rna helicase
R615_01165	ENOG4105MPD	Cytochrome
R615_01190	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
R615_01200	ENOG4107T0K	Adenylate cyclase
R615_01205	ENOG4105CD3	dihydroorotase
R615_01210	ENOG4105CXT	aspartate transcarbamylase
R615_01215	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
R615_01225	ENOG4108UJU	UPF0301 protein
R615_01240	ENOG4105D7Z	glutathione synthase
R615_01245	ENOG4108UNF	response regulator
R615_01250	ENOG4105M3Z	response regulator
R615_01255	ENOG4108ZGA	chew protein
R615_01260	ENOG4105C8Q	Methyl-accepting chemotaxis
R615_01265	ENOG4105BZU	Histidine kinase
R615_01270	ENOG4105CBS	Chea signal transduction histidine kinase
R615_01275	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
R615_01300	ENOG4105DIJ	Phosphoethanolamine transferase
R615_01330	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
R615_01335	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
R615_01340	ENOG41085FC	arsR family transcriptional regulator
R615_01345	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
R615_01365	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
R615_01370	ENOG4105E7A	Glutamine amidotransferase
R615_01380	ENOG4105CM2	brancheD-chain amino acid aminotransferase
R615_01385	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
R615_01390	ENOG4105D38	putrescine abc transporter
R615_01395	ENOG4105F38	ABC transporter, permease
R615_01400	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
R615_01405	ENOG4107RUE	extracellular solute-binding protein family 1
R615_01415	ENOG4105BZ4	penicillin-binding protein
R615_01435	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
R615_01440	ENOG4108YXA	Membrane
R615_01450	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
R615_01465	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
R615_01480	ENOG4105DR5	peptidase
R615_01485	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
R615_01525	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
R615_01535	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
R615_01560	ENOG4105C75	arginyL-tRNA synthetase
R615_01565	ENOG41063M6	Cell Division Protein
R615_01570	ENOG4105C9U	ATP-dependent DNA helicase RecQ
R615_01595	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
R615_01600	ENOG4105CEN	a g-specific adenine glycosylase
R615_01605	ENOG4105BZU	Histidine kinase
R615_01620	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
R615_01625	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
R615_01630	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
R615_01635	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
R615_01650	ENOG4105C01	Dihydroxy-acid dehydratase
R615_01745	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
R615_01830	ENOG4108ZF3	Phosphatase
R615_01870	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
R615_01880	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
R615_01885	ENOG4108UJD	30S ribosomal protein S9
R615_01890	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
R615_01895	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
R615_01900	ENOG4105EIX	cytochrome c1
R615_01905	ENOG4107MKT	Stringent starvation protein a
R615_01910	ENOG4105KB2	stringent starvation protein b
R615_01915	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
R615_01980	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
R615_01985	ENOG4105VTW	prevent-host-death family
R615_02040	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
R615_02045	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
R615_02050	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
R615_02055	ENOG4105DFF	Rod shape-determining protein mreb
R615_02060	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
R615_02065	ENOG4105VQ7	Rod shape-determining protein MreD
R615_02070	ENOG4108Z03	MAF-like protein
R615_02075	ENOG4105C03	ribonuclease
R615_02090	ENOG4105N42	UPF0307 protein
R615_02095	ENOG4105CJW	magnesium transporter
R615_02105	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
R615_02110	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
R615_02115	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
R615_02120	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
R615_02125	ENOG4108IUZ	ABC transporter
R615_02130	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
R615_02140	ENOG4105C2X	Arabinose 5-phosphate isomerase
R615_02150	ENOG4105DHJ	ABC, transporter
R615_02155	ENOG4105CY3	ABC transporter, permease
R615_02160	ENOG4107PE3	Mammalian cell entry related domain protein
R615_02170	ENOG4105VFK	BolA family
R615_02175	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
R615_02180	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
R615_02185	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
R615_02190	ENOG4105CIH	Imidazole acetol-phosphate transaminase
R615_02195	ENOG4105C0H	protease
R615_02200	ENOG4107QNR	UPF0135 protein
R615_02210	ENOG4105CKW	Inner membrane protein yedI
R615_02215	ENOG4106UX7	integral membrane protein
R615_02225	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
R615_02280	ENOG4105BZU	Histidine kinase
R615_02285	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
R615_02290	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
R615_02295	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
R615_02300	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
R615_02310	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
R615_02320	ENOG4108K5P	(LipO)protein
R615_02325	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
R615_02330	ENOG4108UUM	single-stranded DNA-binding protein
R615_02335	ENOG4107RDB	Major Facilitator
R615_02340	ENOG41086KC	Transcriptional regulator
R615_02345	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
R615_02365	ENOG4105F8J	Adenylate Guanylate cyclase
R615_02375	ENOG4105EAC	phosphoserine phosphatase
R615_02390	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
R615_02395	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
R615_02400	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
R615_02420	ENOG4105W8I	Transcriptional regulator
R615_02425	ENOG4105DJ4	phosphatidylserine decarboxylase
R615_02430	ENOG4105KHC	sulfurtransferase
R615_02440	ENOG4107RD7	Flagellar Motor Protein, MotA
R615_02445	ENOG4105ER2	Ompa motb domain protein
R615_02455	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
R615_02460	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
R615_02465	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
R615_02470	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
R615_02475	ENOG4105K8N	protein family UPF0079, ATPase
R615_02480	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
R615_02485	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
R615_02490	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
R615_02495	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
R615_02500	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
R615_02505	ENOG4107QJR	hflk protein
R615_02510	ENOG4105EPW	hflc protein
R615_02520	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
R615_02525	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
R615_02535	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
R615_02540	ENOG4105CC0	LysR family Transcriptional regulator
R615_02550	ENOG4105C4W	S-formylglutathione hydrolase
R615_02575	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
R615_02580	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
R615_02585	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
R615_02590	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
R615_02595	ENOG4107QP8	phosphohexose isomerase
R615_02600	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
R615_02605	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
R615_02610	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
R615_02615	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
R615_02620	ENOG4105DJ0	Poly(A) Polymerase
R615_02630	ENOG4105BZU	Histidine kinase
R615_02640	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
R615_02645	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
R615_02650	ENOG4105CHM	Aminotransferase
R615_02655	ENOG4105PW4	Sugar fermentation stimulation protein homolog
R615_02670	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
R615_02680	ENOG4105EHG	Permease protein
R615_02700	ENOG4105CQ2	DNA polymerase
R615_02705	ENOG4105D7N	magnesium and cobalt transport protein CorA
R615_02710	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
R615_02725	ENOG4105PXI	polysaccharide deacetylase
R615_02730	ENOG4105CN1	protease
R615_02735	ENOG41063SB	peptidase
R615_02740	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
R615_02745	ENOG4107YZP	Rhodanese domain protein
R615_02750	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
R615_02790	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
R615_02815	ENOG4105GVR	general secretion pathway protein D
R615_02835	ENOG4105D7Q	type ii secretion system
R615_02890	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
R615_02905	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
R615_02910	ENOG4108YY7	Invasion gene expression up-regulator SirB
R615_02930	ENOG4108IJF	Heavy metal efflux pump, CzcA
R615_02935	ENOG4105C8Q	Methyl-accepting chemotaxis
R615_02980	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
R615_02985	ENOG4107QMS	site-determining protein
R615_02990	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
R615_03000	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
R615_03005	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
R615_03010	ENOG4105BZF	Glycosyl transferase (Group 1
R615_03015	ENOG4108ZX5	transcriptional regulator
R615_03030	ENOG4105QDK	Flavodoxin
R615_03055	ENOG4105D5U	fad dependent oxidoreductase
R615_03060	ENOG4108821	RND type efflux pump
R615_03085	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
R615_03105	ENOG4105K6T	rare lipoprotein A
R615_03110	ENOG4105CVE	Lytic murein transglycosylase
R615_03115	ENOG4105CNI	cell division protein FtsW
R615_03120	ENOG4105CJN	penicillin-binding protein
R615_03125	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
R615_03140	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
R615_03165	ENOG4108KF1	Membrane
R615_03175	ENOG4105WP7	tRNA pseudouridine synthase C
R615_03200	ENOG4105DZ1	carboxypeptidase
R615_03205	ENOG41084BA	UPF0250 protein
R615_03210	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
R615_03215	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
R615_03225	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
R615_03235	ENOG4105K63	Thioredoxin
R615_03240	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
R615_03245	ENOG4105EAH	synthase
R615_03250	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
R615_03255	ENOG4105K46	50S ribosomal protein l27
R615_03260	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
R615_03265	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
R615_03270	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
R615_03275	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
R615_03280	ENOG4105CJR	Integral membrane protein (MviN
R615_03285	ENOG4105DTN	riboflavin biosynthesis protein ribF
R615_03290	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
R615_03295	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
R615_03300	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
R615_03305	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
R615_03350	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
R615_03355	ENOG4107TUY	Histidine kinase
R615_03360	ENOG4105C4K	Nad synthetase
R615_03375	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
R615_03380	ENOG4105C34	Pseudouridine synthase
R615_03385	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
R615_03390	ENOG4105C7K	acetolactate synthase
R615_03395	ENOG4108ZP8	Acetolactate synthase small subunit
R615_03400	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
R615_03405	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
R615_03410	ENOG4105BZU	Histidine kinase
R615_03415	ENOG4105C12	Phosphoribosylglycinamide synthetase
R615_03420	ENOG4105DC1	bifunctional purine biosynthesis protein purh
R615_03425	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
R615_03430	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
R615_03440	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
R615_03445	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
R615_03455	ENOG4105BZU	Histidine kinase
R615_03480	ENOG4105C5H	ABC transporter
R615_03485	ENOG4105BZU	Histidine kinase
R615_03505	ENOG4105CGH	5'-nucleotidase
R615_03510	ENOG4105M2J	Glutaredoxin
R615_03515	ENOG4105ECK	Fatty Acid Desaturase
R615_03530	ENOG4107SC1	transglycosylase
R615_03535	ENOG4108WBT	adenosyltransferase
R615_03540	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
R615_03545	ENOG4105BZU	Histidine kinase
R615_03550	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
R615_03560	ENOG4108VPT	UPF0234 protein
R615_03565	ENOG4105EYM	Major Facilitator superfamily
R615_03570	ENOG4105C0B	DNA polymerase III (alpha subunit)
R615_03580	ENOG4108ZD2	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity)
R615_03590	ENOG4105CC0	LysR family Transcriptional regulator
R615_03610	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
R615_03625	ENOG4108W6C	Dehydrogenase
R615_03640	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
R615_03645	ENOG4108XDN	Transcriptional regulator
R615_03650	ENOG4107SEY	Conserved Protein
R615_03660	ENOG4108QDE	fad dependent oxidoreductase
R615_03665	ENOG4105CSU	acyl-Coa dehydrogenase
R615_03670	ENOG4105ECP	epimerase
R615_03740	ENOG4106DF6	pertussis toxin subunit 1
R615_03750	ENOG4105CBC	glutamate synthase
R615_03755	ENOG4105CNG	UPF0061 protein
R615_03765	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
R615_03770	ENOG4105E0C	molybdate abc transporter
R615_03775	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
R615_03785	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
R615_03795	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
R615_03800	ENOG4105CSU	acyl-Coa dehydrogenase
R615_03805	ENOG4105C0A	alcohol dehydrogenase
R615_03835	ENOG4107E2E	PKHD-type hydroxylase
R615_03890	ENOG4105C0D	helicase
R615_03900	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
R615_03905	ENOG4105C8J	)-transporter
R615_03910	ENOG4108Z1B	Cyclase dehydrase
R615_03915	ENOG4105VDB	UPF0125 protein
R615_03920	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
R615_03925	ENOG41090R7	Ferric uptake
R615_03930	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
R615_03935	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
R615_03940	ENOG4105CFG	Acts as a chaperone (By similarity)
R615_03945	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
R615_03950	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
R615_03960	ENOG410630P	Transcriptional regulator
R615_03965	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
R615_03970	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
R615_03975	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
R615_04000	ENOG4105HBR	Rna-binding protein
R615_04005	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
R615_04010	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
R615_04015	ENOG4105EEI	dihydropteroate synthase
R615_04020	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
R615_04025	ENOG4105CP7	Triose-phosphate isomerase
R615_04030	ENOG4107EJC	Preprotein translocase subunit SecG
R615_04040	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
R615_04045	ENOG4105CHV	Transcription elongation factor NusA
R615_04050	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
R615_04055	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
R615_04060	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
R615_04065	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
R615_04070	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
R615_04080	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
R615_04095	ENOG4105JAB	phenazine biosynthesis protein, phzf family
R615_04100	ENOG4105CY0	Metallo-Beta-Lactamase
R615_04105	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
R615_04135	ENOG4105DJV	ribulose-phosphate 3-epimerase
R615_04145	ENOG4105CGY	Dna recombination protein
R615_04150	ENOG4105BZU	Histidine kinase
R615_04155	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
R615_04160	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
R615_04165	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
R615_04175	ENOG4107QSA	Oxaloacetate decarboxylase
R615_04180	ENOG4105D9Q	decarboxylase (Beta subunit)
R615_04185	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
R615_04200	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
R615_04205	ENOG4105VRT	cytoplasmic protein
R615_04215	ENOG4105BZU	Histidine kinase
R615_04220	ENOG4105NBK	UPF0345 protein
R615_04225	ENOG4105C1J	atp-dependent rna helicase
R615_04240	ENOG4106H31	ATP-dependent protease ATP-binding subunit-like protein
R615_04245	ENOG4105DCY	Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity)
R615_04250	ENOG4108IV0	ABC, transporter
R615_04255	ENOG4105C0Z	ABC transporter
R615_04270	ENOG4107TSX	ABC branched chain amino acid family transporter periplasmic ligand binding protein
R615_04275	ENOG4105BZU	Histidine kinase
R615_04280	ENOG4105BZU	Histidine kinase
R615_04290	ENOG4105CYM	Glutathione S-transferase
R615_04295	ENOG4105CYM	Glutathione S-transferase
R615_04305	ENOG4108K3Z	AraC family transcriptional regulator
R615_04310	ENOG4105CPD	ethanolamine ammonia-lyase
R615_04320	ENOG4105CUB	amino acid
R615_04340	ENOG4105C4R	Atp-dependent dna helicase
R615_04345	ENOG4108YZY	peptidylprolyl cis-trans isomerase
R615_04355	ENOG4105F2V	VRR-NUC domain-containing protein
R615_04365	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
R615_04370	ENOG4105EW9	transcriptional regulator AsnC family
R615_04375	ENOG4105BZU	Histidine kinase
R615_04380	ENOG4108ZJT	translation initiation factor, Sui1
R615_04390	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
R615_04400	ENOG4108Z6B	deaminase
R615_04410	ENOG4108ETH	Formylglycinamide ribotide synthetase
R615_04430	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
R615_04470	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
R615_04485	ENOG4107JPU	
R615_04510	ENOG4105K5M	30s ribosomal protein S16
R615_04515	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
R615_04520	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
R615_04525	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
R615_04530	ENOG4105T95	Thiol disulfide interChange protein
R615_04535	ENOG4105DR9	pseudouridine synthase
R615_04540	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
R615_04550	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
R615_04560	ENOG4108IAB	Phoh family
R615_04570	ENOG4108821	RND type efflux pump
R615_04585	ENOG4105C3M	thioredoxin reductase
R615_04595	ENOG4105K8R	UPF0145 protein
R615_04600	ENOG4105K8R	UPF0145 protein
R615_04605	ENOG4107QPN	acyl-Coa dehydrogenase
R615_04700	ENOG4105DFP	Integrase
R615_04725	ENOG4105XZC	flagellar basal body P-ring biosynthesis protein FlgA
R615_04730	ENOG4107R88	Chemotaxis protein (CheV)
R615_04735	ENOG4105BZU	Histidine kinase
R615_04740	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
R615_04745	ENOG4108ZC9	flagellar basal-body rod protein flgc
R615_04750	ENOG4105W00	Flagellar hook capping protein
R615_04755	ENOG4105BZE	flagellar hook protein, FlgE
R615_04760	ENOG4108KPB	Flagellar basal-body rod protein FlgF
R615_04765	ENOG4105CGA	flagellar basal-body rod protein FlgG
R615_04770	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
R615_04785	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
R615_04790	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
R615_04800	ENOG4105DTJ	flagellar hook-associated protein
R615_04805	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
R615_04820	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
R615_04870	ENOG4105C30	Nad-dependent epimerase dehydratase
R615_04875	ENOG4105FGF	GDP-mannose mannosyl hydrolase
R615_04930	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
R615_04940	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
R615_04970	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
R615_04980	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
R615_04995	ENOG4105CY0	Metallo-Beta-Lactamase
R615_05020	ENOG4108QV3	biosynthesis protein
R615_05035	ENOG41063QE	flagellar protein FlaG
R615_05040	ENOG4105DTS	flagellar hook-associated
R615_05055	ENOG4105CRK	lysyL-tRNA synthetase
R615_05060	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
R615_05065	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
R615_05070	ENOG4105MQ3	flagellar protein FliS
R615_05075	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
R615_05085	ENOG4105BZU	Histidine kinase
R615_05090	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
R615_05095	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
R615_05100	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
R615_05105	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
R615_05115	ENOG4108JIR	Flagellum-specific ATP synthase
R615_05135	ENOG4105CBS	Chea signal transduction histidine kinase
R615_05150	ENOG4105BZU	Histidine kinase
R615_05155	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
R615_05160	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
R615_05170	ENOG4105M3Z	response regulator
R615_05190	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
R615_05195	ENOG4105DD5	Flagellar motor switch protein
R615_05200	ENOG4105VTB	flagellar biosynthesis protein fliO
R615_05205	ENOG4105CN7	Flagellar biosynthetic protein FliP
R615_05210	ENOG4105VS8	Flagellar biosynthetic protein fliq
R615_05215	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
R615_05220	ENOG4105D00	flagellar biosynthetic protein flhB
R615_05230	ENOG4105D7B	Flagellar biosynthesis protein flha
R615_05235	ENOG4105FZW	flagellar biosynthesis regulator FlhF
R615_05240	ENOG4107R21	site-determining protein
R615_05245	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
R615_05250	ENOG4108VYJ	response regulator receiver protein
R615_05255	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
R615_05260	ENOG4105CBS	Chea signal transduction histidine kinase
R615_05265	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
R615_05270	ENOG4107QJE	Chromosome Partitioning Protein
R615_05285	ENOG4108V3W	Chemotaxis protein, CheW
R615_05315	ENOG4108ZX5	transcriptional regulator
R615_05320	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
R615_05325	ENOG4105XPH	Ferredoxin
R615_05330	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
R615_05335	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
R615_05340	ENOG4107EXC	regulatoR
R615_05345	ENOG4105E0F	Histidine kinase
R615_05350	ENOG4105DZ2	Transcriptional regulator
R615_05355	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
R615_05360	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
R615_05365	ENOG4105BZU	Histidine kinase
R615_05370	ENOG4105DBV	ornithine carbamoyltransferase
R615_05375	ENOG4105C8Y	Acetylornithine aminotransferase
R615_05380	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
R615_05405	ENOG4107RJX	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
R615_05410	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
R615_05440	ENOG4105C1J	atp-dependent rna helicase
R615_05445	ENOG4105EUB	pirin domain protein
R615_05450	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
R615_05455	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
R615_05460	ENOG4105CE9	30S ribosomal protein S2
R615_05465	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
R615_05470	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
R615_05475	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
R615_05480	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
R615_05485	ENOG4105KNE	Phosphatidate cytidylyltransferase
R615_05495	ENOG4105DZP	Membrane-associated zinc metalloprotease
R615_05515	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
R615_05520	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
R615_05525	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
R615_05530	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
R615_05540	ENOG4105CBX	hi0933 family
R615_05550	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
R615_05570	ENOG4107RET	Isocitrate lyase
R615_05575	ENOG4108DEF	Globin
R615_05590	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
R615_05595	ENOG4105E39	Enoyl-CoA hydratase
R615_05600	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
R615_05615	ENOG4107Z6I	Thiamine biosynthesis protein
R615_05620	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
R615_05640	ENOG4105MRR	Transcriptional regulator (By similarity)
R615_05660	ENOG4105CHM	Aminotransferase
R615_05665	ENOG4105D6E	homoserine dehydrogenase
R615_05685	ENOG4105FE9	pseudouridine synthase
R615_05690	ENOG4105DSB	aldose 1-epimerase
R615_05695	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
R615_05705	ENOG4105XTV	UPF0231 protein
R615_05710	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
R615_05715	ENOG4105EKE	dihydroorotase
R615_05720	ENOG4105UYK	outer membrane protein a
R615_05725	ENOG4105CDH	Citrulline--aspartate ligase
R615_05745	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
R615_05750	ENOG4105C4R	Atp-dependent dna helicase
R615_05790	ENOG4105D3G	Pseudouridine synthase
R615_05795	ENOG4108821	RND type efflux pump
R615_05820	ENOG4108VKG	metal-dependent hydrolase
R615_05835	ENOG4105DUM	transcriptional regulator, lysR family
R615_05840	ENOG4105DP0	ferredoxin-NADP reductase
R615_05850	ENOG4105HDD	phospholipase
R615_05860	ENOG4108NVR	Methyl-accepting chemotaxis
R615_05865	ENOG4108UYE	Lactoylglutathione lyase
R615_05870	ENOG4105CSM	endonuclease III
R615_05880	ENOG4108ZG0	Ompa motb domain protein
R615_05885	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
R615_05890	ENOG4105KUZ	arsenate reductase
R615_05895	ENOG4105BZU	Histidine kinase
R615_05900	ENOG4108NVR	Methyl-accepting chemotaxis
R615_05905	ENOG4106CJB	Phospholipase Carboxylesterase
R615_05920	ENOG4108Z4V	iron-sulfur cluster assembly
R615_05925	ENOG4105C9B	Cysteine desulfurase
R615_05930	ENOG4105JRK	feS assembly protein SufD
R615_05935	ENOG4105C3K	feS assembly ATPase SufC
R615_05955	ENOG4105CUZ	uba thif-type nad fad binding protein
R615_05995	ENOG4105KT7	mgtC SapB transporter
R615_06000	ENOG4105R8A	Heat shock protein
R615_06020	ENOG4108NVR	Methyl-accepting chemotaxis
R615_06030	ENOG4108V0E	nucleoside 2-deoxyribosyltransferase YtoQ
R615_06040	ENOG4105CS1	NAD(P)H quinone oxidoreductase
R615_06045	ENOG4105K89	arsenate reductase
R615_06050	ENOG4107S2Z	UPF0761 membrane protein
R615_06085	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
R615_06090	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
R615_06110	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
R615_06120	ENOG4105YP7	UPF0270 protein
R615_06125	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
R615_06135	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
R615_06150	ENOG4105K9H	YciI-like protein
R615_06155	ENOG4107835	probably involved in intracellular septation (By similarity)
R615_06160	ENOG4105DB7	PHP domain protein
R615_06165	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
R615_06170	ENOG4105C31	Tryptophanyl-tRNA synthetase
R615_06175	ENOG4105C31	Tryptophanyl-tRNA synthetase
R615_06185	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
R615_06190	ENOG4105FE9	pseudouridine synthase
R615_06195	ENOG4105BZU	Histidine kinase
R615_06200	ENOG4105UBK	short-chain dehydrogenase reductase
R615_06205	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
R615_06215	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
R615_06220	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
R615_06230	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
R615_06235	ENOG4105CQC	Prephenate dehydratase
R615_06240	ENOG4105CIH	Imidazole acetol-phosphate transaminase
R615_06245	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
R615_06250	ENOG4105CAT	Cytidine monophosphate kinase
R615_06255	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
R615_06260	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
R615_06265	ENOG4105CFV	Tetratricopeptide repeat protein
R615_06270	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
R615_06280	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
R615_06285	ENOG4107QQG	Dehydrogenase
R615_06290	ENOG4107R5Z	Oxidoreductase domain protein
R615_06295	ENOG4105J5G	Transferase hexapeptide repeat containing protein
R615_06300	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
R615_06315	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
R615_06335	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
R615_06355	ENOG4105D3Q	Sugar transferase
R615_06380	ENOG4105CMR	udp-glucose 4-epimerase
R615_06385	ENOG4105DHP	deoxycytidine triphosphate deaminase
R615_06395	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
R615_06415	ENOG4105CHM	Aminotransferase
R615_06420	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
R615_06440	ENOG4108ZX5	transcriptional regulator
R615_06455	ENOG4105CGH	5'-nucleotidase
R615_06460	ENOG4105ENE	Histidine kinase
R615_06465	ENOG4108VB1	regulatoR
R615_06475	ENOG4105CVR	type I restriction-modification system
R615_06515	ENOG4105DZR	Type I site-specific deoxyribonuclease
R615_06555	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
R615_06560	ENOG4107T9Q	phosphonate abc transporter
R615_06565	ENOG4105D5T	phosphonate abc transporter
R615_06570	ENOG4105S7S	phosphonate abc transporter
R615_06605	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
R615_06615	ENOG4105CEY	Amp-dependent synthetase and ligase
R615_06620	ENOG4105CND	Glycosyl transferase, family 2
R615_06640	ENOG4105D7W	serine acetyltransferase
R615_06710	ENOG4105C22	threonyL-tRNA synthetase
R615_06715	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
R615_06720	ENOG41082NX	50s ribosomal protein l35
R615_06725	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
R615_06730	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
R615_06735	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
R615_06740	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
R615_06760	ENOG4105CHR	reductase
R615_06780	ENOG4108V5Q	transglutaminase-like protein
R615_06785	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
R615_06830	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
R615_06835	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
R615_06840	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
R615_06845	ENOG410624X	efflux transporter, rnd family, mfp subunit
R615_06860	ENOG4108WF3	methyltransferase
R615_06865	ENOG4105IUQ	nucleoprotein polynucleotide-associated enzyme
R615_06870	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
R615_06875	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
R615_06880	ENOG4105BZU	Histidine kinase
R615_06890	ENOG4105C1G	acyl-Coa dehydrogenase
R615_06895	ENOG4105C1G	acyl-Coa dehydrogenase
R615_06900	ENOG4105D1Q	UPF0246 protein
R615_06910	ENOG4105CN1	protease
R615_06920	ENOG4105HEI	LysR family (Transcriptional regulator
R615_06930	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
R615_06940	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
R615_06945	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
R615_06950	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
R615_06955	ENOG4107YD3	Thioesterase
R615_06960	ENOG4105E02	MotA TolQ exbB proton channel
R615_06965	ENOG4105M8F	Biopolymer transport protein exbD tolR
R615_06975	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
R615_06980	ENOG4105KCK	Peptidoglycan-associated lipoprotein
R615_06985	ENOG4105UFD	tol-pal system protein YbgF
R615_07000	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
R615_07005	ENOG4105ERG	peptidase m48, ste24p
R615_07020	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
R615_07035	ENOG4105C8V	SAICAR synthetase
R615_07055	ENOG4108V1T	peptidylprolyl cis-trans isomerase
R615_07075	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
R615_07080	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
R615_07085	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
R615_07090	ENOG4105C01	Dihydroxy-acid dehydratase
R615_07095	ENOG4108UHU	Aldolase
R615_07115	ENOG4105C3Q	Glycosyl transferase, family 2
R615_07120	ENOG4108ZFX	Mannosyl-3-phosphoglycerate phosphatase
R615_07125	ENOG4105DBI	uridine monophosphokinase
R615_07135	ENOG4105BZU	Histidine kinase
R615_07170	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
R615_07185	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
R615_07190	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
R615_07195	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
R615_07220	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
R615_07230	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
R615_07235	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
R615_07240	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
R615_07260	ENOG4108JA2	transcriptioN-repair coupling factor
R615_07270	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
R615_07275	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
R615_07280	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
R615_07295	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
R615_07305	ENOG4105NVB	glycoside hydrolase, family 19
R615_07310	ENOG4108W6C	Dehydrogenase
R615_07460	ENOG4105EG6	Saccharopine dehydrogenase
R615_07465	ENOG41082YX	Transcriptional regulator, arsr family
R615_07475	ENOG4105D6J	arsenicaL-resistance protein
R615_07490	ENOG4105C26	Dehydrogenase
R615_07495	ENOG4108V1T	peptidylprolyl cis-trans isomerase
R615_07505	ENOG4105C1J	atp-dependent rna helicase
R615_07510	ENOG4108VWS	Yaeq family
R615_07530	ENOG4105BZU	Histidine kinase
R615_07540	ENOG4108ZX5	transcriptional regulator
R615_07545	ENOG4105CEY	Amp-dependent synthetase and ligase
R615_07550	ENOG4105CSU	acyl-Coa dehydrogenase
R615_07555	ENOG4105BZU	Histidine kinase
R615_07560	ENOG4105EIF	outer membrane protein W
R615_07570	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
R615_07575	ENOG4105EUJ	GTP cyclohydrolase i
R615_07580	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
R615_07585	ENOG4105BZU	Histidine kinase
R615_07605	ENOG41080HT	Transcriptional regulator, arsr family
R615_07635	ENOG4105M85	Bola protein
R615_07640	ENOG4105VV6	START domain-containing protein
R615_07665	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
R615_07675	ENOG4108RRZ	Transcription elongation factor GreB
R615_07685	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
R615_07695	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
R615_07725	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
R615_07740	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
R615_07785	ENOG4107RX2	synthase
R615_07795	ENOG4105RAK	Histidine kinase
R615_07800	ENOG4105BZU	Histidine kinase
R615_07810	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
R615_07815	ENOG4105BZU	Histidine kinase
R615_07820	ENOG4105BZU	Histidine kinase
R615_07835	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
R615_07865	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
R615_07880	ENOG4105C9M	aspartyl-trna synthetase
R615_07925	ENOG4108I0Z	Aconitate hydratase
R615_07965	ENOG4107QIJ	Aconitate hydratase 2
R615_07975	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
R615_07980	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
R615_07990	ENOG4105CHM	Aminotransferase
R615_07995	ENOG4105E0X	reductase
R615_08000	ENOG4108V06	Glutathione peroxidase
R615_08005	ENOG4105K56	Transcriptional regulator
R615_08040	ENOG4105DA5	(ABC) transporter
R615_08045	ENOG4105E3A	(ABC) transporter
R615_08050	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
R615_08055	ENOG4105F8J	Adenylate Guanylate cyclase
R615_08070	ENOG4105BZU	Histidine kinase
R615_08075	ENOG4108ZX5	transcriptional regulator
R615_08090	ENOG4105C8Q	Methyl-accepting chemotaxis
R615_08095	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
R615_08120	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
R615_08135	ENOG4105EZE	Cupin 4 family protein
R615_08140	ENOG4107QTF	adenylosuccinate lyase
R615_08165	ENOG4107QP3	malate synthase g
R615_08190	ENOG4105DVT	helicase
R615_08205	ENOG4105D60	lipoprotein releasing system transmembrane protein
R615_08210	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
R615_08220	ENOG4108EC8	DNA internalization-related competence protein ComEC
R615_08230	ENOG4109015	Biopolymer transport protein exbD tolR
R615_08235	ENOG4105BZ1	(ABC) transporter
R615_08240	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
R615_08245	ENOG4105W49	UPF0434 protein
R615_08260	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
R615_08265	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
R615_08270	ENOG4105CX6	glutaminyL-tRNA synthetase
R615_08275	ENOG4105C8N	cysteinyl-tRNA synthetase
R615_08295	ENOG4105EN6	Membrane
R615_08315	ENOG4105D8V	Glucose sorbosone dehydrogenase
R615_08320	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
R615_08345	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
R615_08350	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
R615_08355	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
R615_08360	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
R615_08365	ENOG4105K70	DNA-binding protein
R615_08375	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
R615_08380	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
R615_08390	ENOG4105E9H	Lytic Murein transglycosylase
R615_08400	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
R615_08405	ENOG4107RZZ	dna polymerase iii epsilon subunit
R615_08410	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
R615_08430	ENOG4105ERU	peptidase
R615_08440	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
R615_08450	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
R615_08455	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
R615_08460	ENOG4105UQX	Mate efflux family protein
R615_08465	ENOG4105C3R	Methionine synthase
R615_08470	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
R615_08480	ENOG4105I93	response regulator
R615_08490	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
R615_08500	ENOG410902C	phosphohistidine phosphatase, SixA
R615_08520	ENOG4105D3G	Pseudouridine synthase
R615_08525	ENOG4105CFP	Peptidase U32
R615_08565	ENOG4105CJ2	(LipO)protein
R615_08575	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
R615_08590	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
R615_08595	ENOG4105WZW	rhodanese family
R615_08600	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
R615_08605	ENOG41075W9	High frequency lysogenization protein HflD homolog
R615_08620	ENOG4108R99	pseudouridine synthase
R615_08625	ENOG4105E9K	Isocitrate dehydrogenase
R615_08630	ENOG4105VEQ	Cold shock protein
R615_08635	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
R615_08640	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
R615_08645	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
R615_08650	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
R615_08655	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
R615_08660	ENOG4105CNU	cell division protein FtsK
R615_08665	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
R615_08670	ENOG4105D1H	recombination factor protein RarA
R615_08675	ENOG4105WMR	Protein CrcB homolog
R615_08680	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
R615_08695	ENOG4108NVR	Methyl-accepting chemotaxis
R615_08700	ENOG4107QYG	anthranilate phosphoribosyltransferase
R615_08705	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
R615_08715	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
R615_08720	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
R615_08735	ENOG4105CD5	CoA-binding domain protein
R615_08740	ENOG4105WH1	Two component transcriptional regulator luxr family
R615_08745	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
R615_08750	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
R615_08785	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
R615_08790	ENOG4105BZJ	Electron transfer flavoprotein
R615_08795	ENOG4105C10	Electron transfer flavoprotein
R615_08800	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
R615_08805	ENOG4107QHF	type ii secretion system protein e
R615_08810	ENOG4105D7Q	type ii secretion system
R615_08815	ENOG4108VAU	general secretion pathway protein G
R615_08820	ENOG4105VWV	general secretion pathway protein h
R615_08825	ENOG4105X5Z	General secretion pathway protein I
R615_08830	ENOG4108WWZ	General secretion pathway protein J
R615_08850	ENOG4105DC8	reductase
R615_08855	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
R615_08865	ENOG4105CSR	polyphosphate kinase 2
R615_08875	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
R615_08880	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
R615_08915	ENOG4105C59	p-type ATPase
R615_08970	ENOG4105E3B	Multicopper oxidase
R615_08980	ENOG4105GR3	Histidine kinase
R615_09005	ENOG4108IJF	Heavy metal efflux pump, CzcA
R615_09010	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
R615_09045	ENOG4107QM5	aconitate hydratase
R615_09070	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
R615_09085	ENOG4105W1Y	Transcriptional regulator
R615_09100	ENOG4107SJW	iron permease, FTR1
R615_09105	ENOG4105W1Y	Transcriptional regulator
R615_09110	ENOG4105PGM	cation diffusion facilitator family transporter
R615_09140	ENOG4105PGM	cation diffusion facilitator family transporter
R615_09145	ENOG4105KK4	UPF0060 membrane protein
R615_09170	ENOG4105CHR	reductase
R615_09180	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
R615_09200	ENOG4105CGK	Exodeoxyribonuclease III
R615_09220	ENOG4109015	Biopolymer transport protein exbD tolR
R615_09245	ENOG4105C3J	Cysteine desulfurase
R615_09260	ENOG41069AG	Ankyrin repeat
R615_09280	ENOG4107QRG	dna polymerase iii
R615_09285	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
R615_09290	ENOG4105HHA	aminodeoxychorismate lyase
R615_09295	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
R615_09300	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
R615_09305	ENOG4105CHR	reductase
R615_09310	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
R615_09315	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
R615_09320	ENOG4105VGS	50s ribosomal protein l32
R615_09335	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
R615_09340	ENOG4105EI2	Pseudouridine synthase
R615_09345	ENOG4105C03	ribonuclease
R615_09350	ENOG4105C7F	AcnD-accessory protein PrpF
R615_09355	ENOG4105BZU	Histidine kinase
R615_09360	ENOG4108I0Z	Aconitate hydratase
R615_09365	ENOG4105BZN	citrate synthase
R615_09370	ENOG4105CR4	methylisocitrate lyase
R615_09375	ENOG41073TP	transcriptional regulator
R615_09405	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
R615_09440	ENOG4105CRQ	synthase (Component I)
R615_09445	ENOG4105ECA	phosphoserine phosphatase homoserine phosphotransferase bifunctional protein
R615_09455	ENOG4107R11	Transcriptional regulator
R615_09460	ENOG4107TSN	permease
R615_09470	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
R615_09475	ENOG410903C	(LipO)protein
R615_09485	ENOG4105E18	UPF0276 protein
R615_09495	ENOG4105CQ7	ATP-dependent helicase
R615_09500	ENOG4105CEY	Amp-dependent synthetase and ligase
R615_09505	ENOG4108Z7G	MaoC domain protein dehydratase
R615_09595	ENOG4108ZZ3	UPF0260 protein
R615_09600	ENOG4105VNG	YcgL domain-containing protein
R615_09610	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
R615_09615	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
R615_09635	ENOG4105BZU	Histidine kinase
R615_09660	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
R615_09665	ENOG4108TGP	Thioesterase superfamily protein
R615_09670	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
R615_09675	ENOG4108JJ7	ABC transporter
R615_09705	ENOG4108BPE	-transporting atpase
R615_09710	ENOG4107QI1	Mate efflux family protein
R615_09720	ENOG4108Z86	Glutamine amidotransferase
R615_09745	ENOG4108NVR	Methyl-accepting chemotaxis
R615_09770	ENOG4105CPC	Aldo Keto reductase
R615_09775	ENOG4105C8Q	Methyl-accepting chemotaxis
R615_09790	ENOG4105F8C	transglutaminase domain-containing protein
R615_09800	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
R615_09805	ENOG4105C28	cystathionine
R615_09810	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
R615_09815	ENOG4105E96	Colicin v production protein
R615_09825	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
R615_09830	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
R615_09835	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
R615_09840	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
R615_09855	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
R615_09870	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
R615_09880	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
R615_09885	ENOG4108MP6	LysR family Transcriptional regulator
R615_09890	ENOG4105Q9Y	Universal stress protein
R615_09895	ENOG4107QYA	phosphate
R615_09900	ENOG4105CH2	amidohydrolase
R615_09905	ENOG4108JPW	Aminotransferase
R615_09910	ENOG4105DC7	peptidase M24
R615_09915	ENOG4105C26	Dehydrogenase
R615_09925	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
R615_09935	ENOG41081QV	Universal stress protein
R615_09945	ENOG4105DQ6	Transposase
R615_09960	ENOG4105PGM	cation diffusion facilitator family transporter
R615_09980	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
R615_09985	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
R615_09990	ENOG4107QN2	dihydrolipoyl dehydrogenase
R615_09995	ENOG4105C7S	Dehydrogenase
R615_10000	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
R615_10005	ENOG4105E33	succinate dehydrogenase
R615_10010	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
R615_10015	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
R615_10020	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
R615_10025	ENOG4105BZN	citrate synthase
R615_10030	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
R615_10040	ENOG4107R88	Chemotaxis protein (CheV)
R615_10045	ENOG4105D58	Diguanylate phosphodiesterase
R615_10050	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
R615_10060	ENOG4105D16	lipopolysaccharide heptosyltransferase i
R615_10070	ENOG4105CKK	Glycosyl transferase, family 2
R615_10090	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
R615_10100	ENOG4107QYX	exodeoxyribonuclease v alpha
R615_10105	ENOG4107QKA	exodeoxyribonuclease V beta
R615_10110	ENOG4105DSY	exodeoxyribonuclease V, gamma
R615_10155	ENOG4105DCF	alanine dehydrogenase
R615_10165	ENOG4105CNM	Receptor
R615_10190	ENOG4105CCT	upf0313 protein
R615_10205	ENOG4105I5W	Transporter
R615_10215	ENOG4105D7T	ABC transporter
R615_10225	ENOG4108IFG	nitrite reductase, (NAD(P)H)
R615_10240	ENOG4107R3J	Transporter
R615_10245	ENOG4105WZK	nitrite reductase NADPH small subunit
R615_10250	ENOG4107QZF	nitrite reductase NADPH large subunit
R615_10260	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
R615_10325	ENOG4108R3E	Dna-3-methyladenine glycosylase i
R615_10335	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
R615_10340	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
R615_10355	ENOG4108821	RND type efflux pump
R615_10360	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
R615_10365	ENOG4105W8H	transhydrogenase (subunit alpha
R615_10370	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
R615_10375	ENOG4105DWT	malate dehydrogenase (quinone)
R615_10410	ENOG4105I08	Pseudouridine synthase
R615_10440	ENOG4105E0F	Histidine kinase
R615_10445	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
R615_10455	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
R615_10465	ENOG4108JQ5	ABC transporter
R615_10470	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
R615_10480	ENOG4107QSI	ABC, transporter
R615_10490	ENOG4105DGN	Electron transport complex
R615_10495	ENOG4108R3D	Electron transport complex
R615_10505	ENOG4105D6A	Electron transport complex
R615_10510	ENOG4108UQQ	Electron transport complex
R615_10515	ENOG4105DZB	Electron transport complex
R615_10525	ENOG4105C72	UPF0176 protein
R615_10555	ENOG4108IND	Tetr family transcriptional regulator
R615_10570	ENOG4105C8Q	Methyl-accepting chemotaxis
R615_10620	ENOG4105DQ6	Transposase
R615_10640	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
R615_10655	ENOG4105I08	Pseudouridine synthase
R615_10660	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
R615_10675	ENOG4105W1Y	Transcriptional regulator
R615_10695	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
R615_10705	ENOG4108Z0R	Transferase
R615_10730	ENOG4105KRS	Proteinase inhibitor
R615_10755	ENOG4105BZS	acriflavin resistance protein
R615_10760	ENOG4105US7	Histidine kinase
R615_10805	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
R615_10815	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
R615_10835	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
R615_10900	ENOG4108W15	Protein of unknown function (DUF1456)
R615_10915	ENOG4105C5I	Dehydrogenase
R615_10920	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
R615_10935	ENOG4108MN8	Membrane
R615_10940	ENOG41063Z6	transcriptional regulator, lysR family
R615_10950	ENOG4105D6S	protein involved in catabolism of external DNA
R615_10955	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
R615_10960	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
R615_10965	ENOG4105VIE	preprotein translocase, subunit YajC
R615_10970	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
R615_11010	ENOG4108IFH	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
R615_11030	ENOG4105CHR	reductase
R615_11040	ENOG4105D6Z	AFG1 family ATPase
R615_11045	ENOG4105DHZ	alpha beta
R615_11050	ENOG4105C11	sulfate adenylyltransferase), subunit 2
R615_11055	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
R615_11085	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
R615_11095	ENOG4108K5H	permease YjgP YjgQ family protein
R615_11100	ENOG4108M8S	permease YjgP YjgQ family protein
R615_11110	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
R615_11125	ENOG4105KCK	Peptidoglycan-associated lipoprotein
R615_11145	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
R615_11150	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
R615_11170	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
R615_11175	ENOG4105DR5	peptidase
R615_11190	ENOG4105C29	acyl-CoA thioesterase
R615_11195	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
R615_11200	ENOG4105C1J	atp-dependent rna helicase
R615_11205	ENOG4108821	RND type efflux pump
R615_11210	ENOG4105EUB	pirin domain protein
R615_11225	ENOG4108R3E	Dna-3-methyladenine glycosylase i
R615_11235	ENOG4105CJB	Exodeoxyribonuclease I
R615_11240	ENOG4106HB6	Alpha beta hydrolase
R615_11260	ENOG4105EYM	Major Facilitator superfamily
R615_11270	ENOG4105CHR	reductase
R615_11275	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
R615_11285	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
R615_11295	ENOG4105EGS	Mechanosensitive ion channel
R615_11315	ENOG4105CQ7	ATP-dependent helicase
R615_11320	ENOG4105EJ9	Membrane
R615_11325	ENOG4105DQ6	Transposase
R615_11335	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
R615_11340	ENOG4105VTW	prevent-host-death family
R615_11350	ENOG4105EQR	Transposase IS116 IS110 IS902
R615_11375	ENOG4108R6K	riboflavin synthase, subunit alpha
R615_11385	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
R615_11440	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
R615_11445	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
R615_11465	ENOG4105C7I	Dehydrogenase
R615_11470	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
R615_11485	ENOG4107QVM	von Willebrand factor, type A
R615_11520	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
R615_11525	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
R615_11530	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
R615_11535	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
R615_11545	ENOG4105EEF	Alkane 1-monooxygenase
R615_11570	ENOG4105CFC	Transporter
R615_11580	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
R615_11615	ENOG41080VW	acetyltransferase
R615_11670	ENOG4105CHU	acetyl-coa acetyltransferase
R615_11690	ENOG4105C5H	ABC transporter
R615_11695	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
R615_11745	ENOG4108I9W	Membrane
R615_11755	ENOG4105D25	secreted protein
R615_11760	ENOG4105CD8	aminopeptidase N
R615_11775	ENOG4105EBW	Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity)
R615_11780	ENOG4107S1Q	Phosphatase
R615_11785	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
R615_11860	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
R615_11885	ENOG4105C3F	Signal peptidase i
R615_11890	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
R615_11895	ENOG4105C37	(CBS) domain
R615_11910	ENOG41081FY	multiple antibiotic resistance (MarC)-related
R615_11925	ENOG4107QN1	sodium solute
R615_11935	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
R615_11950	ENOG4105BZU	Histidine kinase
R615_11970	ENOG4107QN1	sodium solute
R615_11980	ENOG4105BZU	Histidine kinase
R615_11990	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
R615_12030	ENOG4108M1T	Cytochrome c-type biogenesis protein
R615_12035	ENOG4105KWW	Biogenesis protein
R615_12040	ENOG4107QX9	Thiol disulfide interChange protein
R615_12045	ENOG4105DA4	cytochrome c-type biogenesis protein
R615_12055	ENOG41067VX	Heme exporter protein
R615_12060	ENOG41060IM	Heme exporter protein
R615_12065	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
R615_12070	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
R615_12080	ENOG4105D00	flagellar biosynthetic protein flhB
R615_12090	ENOG4105HDK	L-asparaginase
R615_12100	ENOG4105D4P	Coproporphyrinogen iii oxidase
R615_12145	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
R615_12150	ENOG4105C6K	Malic enzyme
R615_12155	ENOG4106HNH	Acyl-transferase
R615_12165	ENOG4105C6T	cysteine synthase
R615_12180	ENOG41076HS	cation diffusion facilitator family transporter
R615_12190	ENOG4108UNF	response regulator
R615_12220	ENOG4105BZU	Histidine kinase
R615_12230	ENOG4107VQW	regulatoR
R615_12240	ENOG4107QXK	peptidase
R615_12250	ENOG4107RN6	Monooxygenase
R615_12285	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
R615_12290	ENOG4105BZS	acriflavin resistance protein
R615_12300	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
R615_12315	ENOG4108VHC	Short-chain dehydrogenase reductase Sdr
R615_12340	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
R615_12350	ENOG4105D25	secreted protein
R615_12360	ENOG4105EYA	deoxyribonuclease
R615_12365	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
R615_12375	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
R615_12380	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
R615_12395	ENOG4105CE1	Ferrous iron transport protein b
R615_12405	ENOG4105C09	Bile acid
R615_12420	ENOG4105XZD	Fe-S protein
R615_12425	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
R615_12430	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
R615_12435	ENOG4108HU6	Metal dependent phosphohydrolase
R615_12450	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
R615_12460	ENOG4108UQY	Iron-storage protein
R615_12470	ENOG4105D98	threonine synthase
R615_12505	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
R615_12515	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
R615_12525	ENOG4108JU6	CBS domain protein
R615_12530	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
R615_12535	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
R615_12540	ENOG4108YZ9	Urea amidohydrolase subunit gamma
R615_12545	ENOG4105KI2	Urea amidohydrolase subunit beta
R615_12550	ENOG4105CQM	Urea amidohydrolase subunit alpha
R615_12555	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
R615_12560	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
R615_12565	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
R615_12600	ENOG4105CSU	acyl-Coa dehydrogenase
R615_12605	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
R615_12610	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
R615_12615	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
R615_12625	ENOG4105CUT	histidyl-tRNA synthetase
R615_12640	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
R615_12645	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
R615_12655	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
R615_12670	ENOG4105ECY	inositol monophosphatase
R615_12680	ENOG4105VEQ	Cold shock protein
R615_12685	ENOG41069P5	Protein slyX homolog
R615_12690	ENOG4105E55	glycerol-3-phosphate acyltransferase
R615_12695	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
R615_12700	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
R615_12705	ENOG41072GX	Peptidase M22 Glycoprotease
R615_12715	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
R615_12720	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
R615_12725	ENOG4105DXN	mazG family
R615_12730	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
R615_12735	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
R615_12740	ENOG4105C6T	cysteine synthase
R615_12745	ENOG4105BZU	Histidine kinase
R615_12750	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
R615_12760	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
R615_12765	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
R615_12770	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
R615_12780	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
R615_12785	ENOG4105C0H	protease
R615_12795	ENOG4105VQK	sigma E regulatory protein, MucB RseB
R615_12800	ENOG41069E1	anti sigma-E protein RseA
R615_12805	ENOG4105EMN	RNA polymerase sigma factor
R615_12810	ENOG4108IYU	L-aspartate oxidase
R615_12820	ENOG4105Y75	tpr repeat protein
R615_12860	ENOG41067XB	TonB family
R615_12865	ENOG4109015	Biopolymer transport protein exbD tolR
R615_12895	ENOG4105CR8	Transcriptional regulator
R615_12910	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
R615_12915	ENOG4108R96	Methyltransferase, YaeB family
R615_12920	ENOG4105FQ6	thiopurine methyltransferase
R615_12940	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
R615_12950	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
R615_12955	ENOG4105BZ1	(ABC) transporter
R615_12980	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
R615_13105	ENOG4108YGG	dna repair protein
R615_13135	ENOG4105CBD	Diacylglycerol kinase
R615_13145	ENOG4108V8F	Transcriptional regulator, MarR family
R615_13175	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
R615_13185	ENOG41065RQ	ADP-ribosylation crystallin J1
R615_13190	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
R615_13195	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
R615_13200	ENOG41082RQ	UPF0102 protein
R615_13210	ENOG4105D7N	magnesium and cobalt transport protein CorA
R615_13220	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
R615_13225	ENOG4105D06	uba thif-type nad fad binding protein
R615_13230	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
R615_13235	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
R615_13240	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
R615_13245	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
R615_13250	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
R615_13255	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
R615_13265	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
R615_13270	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
R615_13275	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
R615_13280	ENOG4105C3G	gtp-binding protein
R615_13285	ENOG4105C2C	drug resistance transporter, Bcr CflA
R615_13315	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
R615_13320	ENOG4105C9A	Phoh family
R615_13330	ENOG4108JU5	Magnesium and cobalt efflux protein
R615_13335	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
R615_13355	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
R615_13360	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
R615_13365	ENOG4105DR5	peptidase
R615_13370	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
R615_13375	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
R615_13380	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
R615_13385	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
R615_13390	ENOG4105CPF	Cell wall formation (By similarity)
R615_13395	ENOG4105DFU	Cell wall formation (By similarity)
R615_13400	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
R615_13405	ENOG4105CNI	cell division protein FtsW
R615_13410	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
R615_13415	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
R615_13420	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
R615_13425	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
R615_13430	ENOG4105CJN	penicillin-binding protein
R615_13440	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
R615_13490	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
R615_13495	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
R615_13500	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
R615_13515	ENOG4105D3R	alkyl hydroperoxide reductase
R615_13535	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
R615_13540	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
R615_13545	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
R615_13550	ENOG4105BZU	Histidine kinase
R615_13575	ENOG4105C8Q	Methyl-accepting chemotaxis
R615_13590	ENOG4107RK0	Sucrose phosphorylase
R615_13595	ENOG4105DWT	malate dehydrogenase (quinone)
R615_13600	ENOG4105QNR	S1 RNA binding domain protein
R615_13615	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
R615_13620	ENOG4105C94	Transporter
R615_13625	ENOG4105C5H	ABC transporter
R615_13630	ENOG4105C8Q	Methyl-accepting chemotaxis
R615_13645	ENOG4105DN9	Na H antiporter
R615_13670	ENOG4105C0B	DNA polymerase III (alpha subunit)
R615_13675	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
R615_13685	ENOG410908U	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
R615_13695	ENOG4105F8V	Hydrolase, tatD family
R615_13705	ENOG4105C1J	atp-dependent rna helicase
R615_13715	ENOG4105D0S	secretion protein (HlyD
R615_13720	ENOG4105CJ1	ABC, transporter
R615_13725	ENOG4105CMI	transporter
R615_13735	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
R615_13740	ENOG4108821	RND type efflux pump
R615_13775	ENOG4105EKQ	RNA-directed DNA polymerase
R615_13800	ENOG4105CT3	Monooxygenase
R615_13820	ENOG4107S78	Band 7 protein
R615_13825	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
R615_13830	ENOG4105CHU	acetyl-coa acetyltransferase
R615_13845	ENOG4108Z6Z	Transcriptional regulator
R615_13850	ENOG4105CHR	reductase
R615_13865	ENOG4108N3W	hemolysin secretion protein
R615_13870	ENOG4107QSN	dihydrolipoamide acetyltransferase
R615_13875	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
R615_13880	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
R615_13885	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
R615_13890	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
R615_13895	ENOG4105GN9	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
R615_13905	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
R615_13910	ENOG4108YZT	Adenosylcobinamide kinase
R615_13920	ENOG4105DKQ	ROK family
R615_13930	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
R615_13935	ENOG4105BZG	amino acid carrier protein
R615_13940	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
R615_13960	ENOG4107QHF	type ii secretion system protein e
R615_13970	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
R615_13975	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
R615_13980	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
R615_13990	ENOG4105WH1	Two component transcriptional regulator luxr family
R615_14005	ENOG41079HR	Phosphate-Selective Porin O and P
R615_14040	ENOG4108V1U	phospholipid-binding protein
R615_14050	ENOG4105EHV	domain protein
R615_14070	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
R615_14075	ENOG4105DFU	Cell wall formation (By similarity)
R615_14080	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
R615_14085	ENOG4105BZU	Histidine kinase
R615_14095	ENOG4107RNH	Outer membrane receptor FepA
R615_14110	ENOG4105F0N	pyrophosphate phospho-hydrolase
R615_14115	ENOG4105BZU	Histidine kinase
R615_14120	ENOG4108XDN	Transcriptional regulator
R615_14125	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
R615_14130	ENOG4108HH4	Major Facilitator Superfamily
R615_14135	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
R615_14140	ENOG4108UKZ	OsmC family
R615_14145	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
R615_14150	ENOG4105DK0	Indole-3-glycerol phosphate synthase
R615_14155	ENOG4107QYG	anthranilate phosphoribosyltransferase
R615_14160	ENOG4105DDQ	anthranilate synthase
R615_14165	ENOG4105CRQ	synthase (Component I)
R615_14185	ENOG4105ST3	Transcriptional regulator
R615_14190	ENOG4105CSU	acyl-Coa dehydrogenase
R615_14195	ENOG4105CSU	acyl-Coa dehydrogenase
R615_14210	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
R615_14215	ENOG4105MJ2	Competence protein
R615_14220	ENOG4105E27	serine threonine protein kinase
R615_14230	ENOG4105D25	secreted protein
R615_14240	ENOG4108M0H	Extracellular lipase
R615_14245	ENOG4105CHU	acetyl-coa acetyltransferase
R615_14265	ENOG4105EWT	decarboxylase family
R615_14270	ENOG4105G6Z	alkaline phosphatase
R615_14275	ENOG4105ZAI	
R615_14285	ENOG4106VK6	Flagellar motor protein
R615_14290	ENOG4107R0U	MotA TolQ exbB proton channel
R615_14310	ENOG41090A4	Pterin carbinolamine dehydratase
R615_14345	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
R615_14350	ENOG4108UHJ	MAF-like protein
R615_14355	ENOG4105GVR	general secretion pathway protein D
R615_14370	ENOG41082IR	Excinuclease ABC C subunit domain protein
R615_14375	ENOG4108UT2	hemolysin iii
R615_14380	ENOG4108YZN	class I peptide chain release factor
R615_14385	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
R615_14390	ENOG4108S0S	Nucleotidyl transferase
R615_14395	ENOG4105EHM	Aminoglycoside phosphotransferase
R615_14400	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
R615_14405	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
R615_14410	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
R615_14415	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
R615_14425	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
R615_14430	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
R615_14435	ENOG4105CYN	Serine protein kinase
R615_14440	ENOG4106AKX	UPF0229 protein
R615_14445	ENOG4105ED1	spovr family
R615_14480	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
R615_14485	ENOG4105EEI	dihydropteroate synthase
R615_14490	ENOG4107ZVW	dihydroneopterin aldolase
R615_14495	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
R615_14500	ENOG4105VCC	30S ribosomal protein S21
R615_14505	ENOG4105KTH	gatB Yqey
R615_14510	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
R615_14515	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
R615_14545	ENOG4108UKI	Enoyl-CoA hydratase
R615_14570	ENOG4108UPT	UPF0178 protein
R615_14580	ENOG4107RN6	Monooxygenase
R615_14585	ENOG4108ZX5	transcriptional regulator
R615_14590	ENOG4105BZU	Histidine kinase
R615_14600	ENOG4106371	Methyltransferase
R615_14610	ENOG4105MP9	class II Aldolase
R615_14630	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
R615_14635	ENOG4105CFH	Aspartokinase
R615_14640	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
R615_14660	ENOG4105D74	hydrolase
R615_14665	ENOG4105CEP	NADH dehydrogenase
R615_14670	ENOG4108ZX5	transcriptional regulator
R615_14675	ENOG4105Y3E	Modulates RecA activity (By similarity)
R615_14680	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
R615_14685	ENOG4107TH8	cina domain protein
R615_14700	ENOG4108IG5	Transcriptional regulator
R615_14710	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
R615_14715	ENOG4108Z4U	Ferredoxin
R615_14720	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
R615_14725	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
R615_14735	ENOG4105C5H	ABC transporter
R615_14740	ENOG4105BZU	Histidine kinase
R615_14745	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
R615_14770	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
R615_14775	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
R615_14785	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
R615_14790	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
R615_14795	ENOG4107YIM	Involved in the transcription termination process (By similarity)
R615_14800	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
R615_14820	ENOG4108Z66	YbaK ebsC protein
R615_14830	ENOG4105C9Q	fumarate hydratase class II
R615_14845	ENOG4105F95	Monooxygenase
R615_14855	ENOG4105DZ0	fad dependent oxidoreductase
R615_14860	ENOG4108RWN	rrna methyltransferase
R615_14865	ENOG4105CV1	Transketolase (EC 2.2.1.1)
R615_14875	ENOG4105C34	Pseudouridine synthase
R615_14880	ENOG4106HB6	Alpha beta hydrolase
R615_14890	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
R615_14920	ENOG4107B2H	carbonic anhydrase
R615_14925	ENOG4107QSA	Oxaloacetate decarboxylase
R615_14930	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
R615_14955	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
R615_15005	ENOG4105DEN	Luciferase family
R615_15020	ENOG4108JU3	Alkyl hydroperoxide reductase
R615_15025	ENOG4105D3R	alkyl hydroperoxide reductase
R615_15030	ENOG4107Y60	(LipO)protein
R615_15040	ENOG4106B0W	Curli production assembly transport component CsgG
R615_15045	ENOG4105D64	Mechanosensitive ion channel
R615_15050	ENOG4105C2N	RNA methyltransferase TrmH family group 3
R615_15055	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
R615_15065	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
R615_15070	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
R615_15075	ENOG4108YZY	peptidylprolyl cis-trans isomerase
R615_15090	ENOG4105C5X	domain protein
R615_15100	ENOG4105VFB	Binds the 23S rRNA (By similarity)
R615_15105	ENOG4105C25	Primosomal protein n'
R615_15110	ENOG4108ZAI	phosphatidylglycerophosphatase a
R615_15120	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
R615_15130	ENOG4105BZU	Histidine kinase
R615_15140	ENOG4105CTB	Polyprenyl synthetase
R615_15150	ENOG4105E14	MotA TolQ exbB proton channel
R615_15155	ENOG4105ER2	Ompa motb domain protein
R615_15165	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
R615_15175	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
R615_15180	ENOG4105KJM	monovalent cation h antiporter subunit g
R615_15185	ENOG4105W4C	monovalent cation H antiporter subunit F
R615_15190	ENOG4105SC1	monovalent cation H antiporter subunit E
R615_15195	ENOG4107R4Z	monovalent cation h antiporter subunit d
R615_15200	ENOG4108ZE9	Monovalent cation H antiporter subunit C
R615_15205	ENOG4105D65	subunit l
R615_15210	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
R615_15220	ENOG4105BZ8	glutamate synthase
R615_15225	ENOG4105CBC	glutamate synthase
R615_15235	ENOG4105D49	3-dehydroquinate synthase
R615_15240	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
R615_15245	ENOG4105E4G	Type IV pilus
R615_15270	ENOG4108JQC	penicillin-binding protein 1A
R615_15275	ENOG4105CQB	FAD linked oxidase domain protein
R615_15280	ENOG4108JQ1	Dehydrogenase
R615_15285	ENOG4108ESY	Metal dependent phosphohydrolase
R615_15290	ENOG4105DKW	ABC transporter
R615_15300	ENOG4105BZU	Histidine kinase
R615_15340	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
R615_15345	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
R615_15350	ENOG4105EMY	transcriptional regulator
R615_15355	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
R615_15360	ENOG4105BZU	Histidine kinase
R615_15365	ENOG4105CIH	Imidazole acetol-phosphate transaminase
R615_15370	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
R615_15395	ENOG4105D2N	Aldolase
R615_15400	ENOG4105BZA	Phosphoglycerate kinase
R615_15405	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
R615_15425	ENOG4105C26	Dehydrogenase
R615_15445	ENOG4107QUY	Guanine deaminase
R615_15455	ENOG4105VT2	5-hydroxyisourate hydrolase
R615_15465	ENOG4105DHG	Allantoate amidinohydrolase
R615_15475	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
R615_15485	ENOG4108JQ9	ABC transporter
R615_15500	ENOG4105DU0	nucleoside hydrolase
R615_15505	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
R615_15530	ENOG4109015	Biopolymer transport protein exbD tolR
R615_15550	ENOG4108R86	Transcriptional regulator
R615_15555	ENOG4107RF4	Phosphodiesterase
R615_15560	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
R615_15570	ENOG4105DQ4	alcohol dehydrogenase
R615_15590	ENOG4105MSB	protein, conserved in bacteria
R615_15595	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
R615_15650	ENOG4105CDU	Replicative dna helicase
R615_15655	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
R615_15665	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
R615_15670	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
R615_15690	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
R615_15705	ENOG4105CKI	cobalamin synthesis protein
R615_15710	ENOG4105ECY	inositol monophosphatase
R615_15720	ENOG4107IFA	Lipase (EC 3.1.1.3)
R615_15725	ENOG4105EA8	2-Nitropropane dioxygenase
R615_15735	ENOG4105E0F	Histidine kinase
R615_15740	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
R615_15750	ENOG4105W87	Cbs domain
R615_15775	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
R615_15815	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
R615_15820	ENOG4105NXV	High-affinity zinc uptake system protein
R615_15825	ENOG4105MYN	Zinc uptake regulation protein
R615_15835	ENOG4105FAV	ABC, transporter
R615_15845	ENOG4107R73	Mate efflux family protein
R615_15935	ENOG4105F8X	type iii restriction
R615_15945	ENOG4107R73	Mate efflux family protein
R615_15955	ENOG4105SKE	transcriptional Regulator LysR family
R615_15960	ENOG4105DS1	cytochrome b561
R615_15965	ENOG4108YYC	ycei family
R615_15980	ENOG4105NHS	Transcriptional regulator, TraR DksA family
R615_16010	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
R615_16015	ENOG4105C4M	(Ubiquinol oxidase) subunit I
R615_16025	ENOG4105BZU	Histidine kinase
R615_16045	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
R615_16055	ENOG4108ZT0	50S ribosomal protein l17
R615_16060	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
R615_16065	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
R615_16070	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
R615_16075	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
R615_16080	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
R615_16085	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
R615_16090	ENOG4105VPB	50S ribosomal protein L30
R615_16095	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
R615_16105	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
R615_16110	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
R615_16115	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
R615_16120	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
R615_16125	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
R615_16130	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
R615_16135	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
R615_16140	ENOG41083MP	50s ribosomal protein l29
R615_16150	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
R615_16155	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
R615_16160	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
R615_16165	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
R615_16170	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
R615_16175	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
R615_16185	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
R615_16190	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
R615_16195	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
R615_16200	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
R615_16205	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
R615_16215	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
R615_16220	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
R615_16225	ENOG4108VZM	50s ribosomal protein L10
R615_16230	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
R615_16235	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
R615_16240	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
R615_16245	ENOG4105PM1	preprotein translocase subunit SecE
R615_16255	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
R615_16260	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
R615_16265	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
R615_16290	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
R615_16295	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
R615_16300	ENOG4108JQB	penicillin-binding protein 1C
R615_16305	ENOG4105DN3	alpha-2-macroglobulin domain protein
R615_16315	ENOG4105UGU	tonB-dependent Receptor
R615_16350	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
R615_16395	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
R615_16455	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
R615_16460	ENOG41085AN	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
R615_16465	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
R615_16470	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
R615_16475	ENOG4105M00	molybdopterin converting factor, subunit 1
R615_16480	ENOG4108ZAF	Molybdopterin
R615_16485	ENOG4105CZX	twitching motility protein
R615_16490	ENOG4105CZX	twitching motility protein
R615_16495	ENOG4105DFA	alanine racemase domain protein
R615_16500	ENOG4105II7	pyrroline-5-carboxylate reductase
R615_16505	ENOG4108VIA	integral membrane protein
R615_16510	ENOG4105VZ9	UPF0235 protein
R615_16515	ENOG4105DWV	Homoserine O-trans-acetylase
R615_16520	ENOG4105DWV	Homoserine O-trans-acetylase
R615_16530	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
R615_16540	ENOG4105CSA	Coproporphyrinogen iii oxidase
R615_16545	ENOG4108NRW	Phospholipase, patatin family
R615_16555	ENOG4105CZK	Aspartate kinase
R615_16560	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
R615_16565	ENOG4108JPW	Aminotransferase
R615_16575	ENOG4105K56	Transcriptional regulator
R615_16580	ENOG4105CHU	acetyl-coa acetyltransferase
R615_16630	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
R615_16635	ENOG4105C7B	Threonine dehydratase
R615_16640	ENOG4105E66	phosphoriboisomerase A
R615_16650	ENOG4105D52	delta-aminolevulinic acid dehydratase
R615_16660	ENOG4105C9X	ppx gppa phosphatase
R615_16665	ENOG4105K63	Thioredoxin
R615_16670	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
R615_16675	ENOG4105CH5	extracellular solute-binding protein, family 7
R615_16680	ENOG4105C4R	Atp-dependent dna helicase
R615_16685	ENOG4106KNT	transcriptional regulator
R615_16700	ENOG4108YZA	Nitrogen regulatory protein pii
R615_16710	ENOG4105W0Z	cytoplasmic protein
R615_16715	ENOG4108IV0	ABC, transporter
R615_16720	ENOG4105C0Z	ABC transporter
R615_16730	ENOG4105C32	Amino acid ABC transporter (Permease)
R615_16740	ENOG4105DRR	Transcriptional regulator, GntR family
R615_16765	ENOG4107QHF	type ii secretion system protein e
R615_16770	ENOG4105I7R	Adenylate cyclase
R615_16775	ENOG4105CWC	Acetylornithine deacetylase
R615_16825	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
R615_16835	ENOG4105HF0	Membrane
R615_16850	ENOG4105EAQ	(twin-arginine translocation) pathway signal
R615_16855	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
R615_16860	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
R615_16885	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
R615_16890	ENOG4105D0A	hydroxylase
R615_16895	ENOG4107RAQ	aminopeptidase
R615_16910	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
R615_16915	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
R615_16940	ENOG4105C5F	glutamine synthetase
R615_16945	ENOG4105CI3	gtp-binding protein typa
R615_16960	ENOG4105C6K	Malic enzyme
R615_16970	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
R615_16975	ENOG4105DSF	transport protein
R615_16990	ENOG41067MG	lrgb family
R615_16995	ENOG4105BZU	Histidine kinase
R615_17000	ENOG4107RK2	ADP-ribose diphosphatase NudE
R615_17005	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
R615_17010	ENOG4105VEJ	Heat shock protein
R615_17015	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
R615_17020	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
R615_17025	ENOG4105BZM	domain protein
R615_17030	ENOG4105D9M	gamma-glutamylcysteine synthetase
R615_17040	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
R615_17045	ENOG4105PBF	Anti-RNA polymerase sigma 70 factor
R615_17075	ENOG410630P	Transcriptional regulator
R615_17080	ENOG4105EUZ	Beta-lactamase domain protein
R615_17090	ENOG4105WD1	Membrane
R615_17135	ENOG4105C5H	ABC transporter
R615_17150	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
R615_17155	ENOG4105M08	Membrane
R615_17160	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
R615_17195	ENOG4105ECF	c-methyltransferase
R615_17200	ENOG41076E6	Uroporphyrinogen-III Synthase
R615_17205	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
R615_17210	ENOG4108NEV	two component transcriptional regulator, LytTR family
R615_17220	ENOG4105CH7	arginosuccinase
R615_17245	ENOG4105NPQ	Pfam:DUF403
R615_17275	ENOG4105BZU	Histidine kinase
R615_17280	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
R615_17300	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
R615_17305	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
R615_17315	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
R615_17325	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
R615_17330	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
R615_17335	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
R615_17340	ENOG41064MJ	ATP synthase, subunit I
R615_17350	ENOG4105FA0	parb-like partition protein
R615_17355	ENOG4107QJE	Chromosome Partitioning Protein
R615_17360	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
R615_17390	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
R615_17395	ENOG4105IFJ	Histidine kinase
R615_17405	ENOG4105EVH	UPF0753 protein
R615_17410	ENOG4108TWJ	NADH dehydrogenase subunit 5
R615_17415	ENOG4105DND	Transcriptional regulator
R615_17435	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
R615_17500	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
R615_17505	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
R615_17510	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
R615_17515	ENOG4105VG0	50S ribosomal protein l34