locus-tag	class	description
R615_00005	COG0592	DNA-directed DNA polymerase activity
R615_00010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
R615_00040	COG1073	alpha beta
R615_00055	COG0668	transmembrane transport
R615_00070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
R615_00080	COG0751	glycine-tRNA ligase activity
R615_00090	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
R615_00135	COG3150	esterase
R615_00140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
R615_00145	COG3151	Protein conserved in bacteria
R615_00150	COG0494	nUDIX hydrolase
R615_00155	COG1538	Outer membrane efflux protein
R615_00160	COG1519	Transferase
R615_00170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
R615_00175	COG1560	Kdo2-lipid A biosynthetic process
R615_00180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
R615_00185	COG0348	domain, Protein
R615_00190	COG0515	serine threonine protein kinase
R615_00195	COG2116	formate transmembrane transporter activity
R615_00200	COG1960	acyl-CoA dehydrogenase activity
R615_00205	COG1028	Short-chain dehydrogenase reductase Sdr
R615_00220	COG1028	Short-chain dehydrogenase reductase Sdr
R615_00230	COG1404	Belongs to the peptidase S8 family
R615_00255	COG5001	Diguanylate cyclase
R615_00255	COG4251	negative regulation of phosphorylation
R615_00255	COG2203	Gaf domain
R615_00255	COG3706	GGDEF domain
R615_00290	COG1404	Belongs to the peptidase S8 family
R615_00300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
R615_00310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
R615_00315	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
R615_00345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
R615_00350	COG1349	DNA-binding transcription factor activity
R615_00355	COG3706	GGDEF domain
R615_00355	COG0745	RESPONSE REGULATOR receiver
R615_00375	COG3245	cytochrome
R615_00380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
R615_00410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
R615_00445	COG4774	siderophore transport
R615_00450	COG0501	Belongs to the peptidase M48B family
R615_00455	COG0784	Response regulator, receiver
R615_00455	COG2205	protein histidine kinase activity
R615_00455	COG5002	protein histidine kinase activity
R615_00505	COG0339	signal peptide processing
R615_00510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
R615_00535	COG2010	Cytochrome c
R615_00560	COG0217	transcriptional regulatory protein
R615_00580	COG0408	coproporphyrinogen oxidase activity
R615_00590	COG0009	L-threonylcarbamoyladenylate synthase
R615_00595	COG0758	DNA mediated transformation
R615_00605	COG0242	peptide deformylase activity
R615_00610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
R615_00620	COG0569	domain protein
R615_00625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
R615_00630	COG0659	secondary active sulfate transmembrane transporter activity
R615_00635	COG0589	response to stress
R615_00640	COG1595	DNA-templated transcription, initiation
R615_00665	COG0745	RESPONSE REGULATOR receiver
R615_00675	COG0742	ribosomal rna small subunit methyltransferase
R615_00685	COG0552	protein localization to endoplasmic reticulum
R615_00690	COG2884	Cell division ATP-binding protein ftsE
R615_00695	COG2177	Part of the ABC transporter FtsEX involved in
R615_00705	COG1607	acyl-coa hydrolase
R615_00725	COG0573	inorganic phosphate transmembrane transporter activity
R615_00735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
R615_00745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
R615_00780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
R615_00805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
R615_00835	COG1301	dicarboxylic acid transport
R615_00850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
R615_00855	COG0583	DNA-binding transcription factor activity
R615_00875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
R615_00880	COG1758	RNA polymerase activity
R615_00885	COG0194	GDP metabolic process
R615_00890	COG3384	dioxygenase
R615_00895	COG1561	YicC-like family, N-terminal region
R615_00900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
R615_00910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
R615_00920	COG1309	transcriptional regulator
R615_00925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
R615_00930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
R615_00935	COG0756	dUTP diphosphatase activity
R615_00940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
R615_00945	COG2003	Belongs to the UPF0758 family
R615_00950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
R615_00955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
R615_00970	COG1434	Gram-negative-bacterium-type cell wall biogenesis
R615_00975	COG0405	Gamma-glutamyltransferase
R615_00980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
R615_00990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
R615_01030	COG0471	metal ion transport
R615_01030	COG3273	potassium ion transport
R615_01045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
R615_01050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
R615_01055	COG0537	adenosine 5'-monophosphoramidase activity
R615_01060	COG0140	phosphoribosyl-ATP diphosphatase activity
R615_01065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
R615_01070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
R615_01080	COG2226	methyltransferase
R615_01095	COG2203	Gaf domain
R615_01095	COG3706	GGDEF domain
R615_01095	COG4251	negative regulation of phosphorylation
R615_01095	COG5001	Diguanylate cyclase
R615_01100	COG3437	response regulator, receiver
R615_01100	COG3850	Histidine kinase
R615_01100	COG2205	protein histidine kinase activity
R615_01100	COG4999	Histidine kinase
R615_01110	COG4206	TonB-dependent receptor
R615_01115	COG2885	chlorophyll binding
R615_01130	COG4181	ATPase activity
R615_01135	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
R615_01140	COG0501	Belongs to the peptidase M48B family
R615_01145	COG1704	LemA family
R615_01160	COG0513	Belongs to the DEAD box helicase family
R615_01210	COG0540	Belongs to the ATCase OTCase family
R615_01215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
R615_01270	COG0643	Histidine kinase
R615_01270	COG2198	Histidine kinase
R615_01275	COG2201	protein-glutamate methylesterase activity
R615_01300	COG2194	sulfuric ester hydrolase activity
R615_01325	COG3562	capsule polysaccharide
R615_01330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
R615_01335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
R615_01340	COG0640	Transcriptional regulator
R615_01345	COG0714	Associated with various cellular activities
R615_01355	COG1305	Transglutaminase-like
R615_01365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
R615_01370	COG0121	glutamine amidotransferase
R615_01390	COG1177	transmembrane transport
R615_01395	COG1176	ABC-type spermidine putrescine transport system, permease component I
R615_01400	COG3842	ATPase activity
R615_01405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
R615_01415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
R615_01435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
R615_01450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
R615_01465	COG0316	Belongs to the HesB IscA family
R615_01480	COG0739	heme binding
R615_01485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
R615_01525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
R615_01535	COG0456	acetyltransferase
R615_01545	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
R615_01560	COG0018	arginyl-trna synthetase
R615_01565	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
R615_01570	COG0514	ATP-dependent DNA helicase (RecQ)
R615_01595	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
R615_01620	COG0131	Imidazoleglycerol-phosphate dehydratase
R615_01630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
R615_01635	COG0107	imidazoleglycerol-phosphate synthase activity
R615_01650	COG0129	dihydroxy-acid dehydratase activity
R615_01815	COG3501	Rhs element vgr protein
R615_01830	COG0631	protein serine/threonine phosphatase activity
R615_01870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
R615_01880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
R615_01885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
R615_01890	COG0723	plastoquinol--plastocyanin reductase activity
R615_01895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
R615_01900	COG2857	Cytochrome c1
R615_01905	COG0625	glutathione transferase activity
R615_01910	COG2969	positive regulation of protein catabolic process
R615_01915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
R615_01980	COG4115	mRNA cleavage
R615_01985	COG2161	toxin-antitoxin pair type II binding
R615_02040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
R615_02045	COG0154	amidase activity
R615_02050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
R615_02055	COG1077	Cell shape determining protein MreB Mrl
R615_02060	COG1792	Involved in formation and maintenance of cell shape
R615_02065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
R615_02070	COG0424	maF-like protein
R615_02075	COG1530	ribonuclease E activity
R615_02085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
R615_02090	COG3028	Belongs to the UPF0307 family
R615_02095	COG2239	Acts as a magnesium transporter
R615_02100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
R615_02105	COG1660	Displays ATPase and GTPase activities
R615_02125	COG1137	ATPase activity
R615_02130	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
R615_02150	COG1127	ABC transporter
R615_02155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
R615_02160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
R615_02170	COG5007	Belongs to the BolA IbaG family
R615_02175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
R615_02180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
R615_02185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
R615_02190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
R615_02195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
R615_02200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
R615_02210	COG2354	Protein conserved in bacteria
R615_02215	COG0697	spore germination
R615_02225	COG0504	CTP synthase activity
R615_02280	COG3706	GGDEF domain
R615_02285	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
R615_02290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
R615_02295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
R615_02300	COG0585	pseudouridine synthase activity
R615_02310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
R615_02330	COG0629	single-stranded DNA binding
R615_02335	COG2814	Major facilitator Superfamily
R615_02340	COG2197	response regulator
R615_02375	COG3830	Belongs to the UPF0237 family
R615_02375	COG0560	Phosphoserine phosphatase
R615_02390	COG1509	lysine 2,3-aminomutase activity
R615_02395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
R615_02420	COG0583	DNA-binding transcription factor activity
R615_02425	COG0688	phosphatidylethanolamine metabolic process
R615_02445	COG1360	Flagellar Motor Protein
R615_02455	COG1162	GTPase activity
R615_02460	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
R615_02470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
R615_02470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
R615_02475	COG0802	atpase or kinase
R615_02480	COG0860	N-Acetylmuramoyl-L-alanine amidase
R615_02485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
R615_02490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
R615_02495	COG1923	regulation of RNA biosynthetic process
R615_02500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
R615_02505	COG0330	HflC and HflK could
R615_02510	COG0330	HflC and HflK could
R615_02520	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
R615_02525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
R615_02535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
R615_02535	COG3153	acetyltransferase
R615_02540	COG0583	DNA-binding transcription factor activity
R615_02575	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
R615_02580	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
R615_02585	COG0235	Class ii aldolase
R615_02590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
R615_02595	COG0166	Belongs to the GPI family
R615_02600	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
R615_02605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
R615_02610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
R615_02615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
R615_02620	COG0617	tRNA 3'-terminal CCA addition
R615_02630	COG4191	Histidine kinase
R615_02640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
R615_02645	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
R615_02655	COG1489	DNA binding
R615_02670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
R615_02670	COG3153	acetyltransferase
R615_02680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
R615_02700	COG0417	DNA replication proofreading
R615_02705	COG0598	Magnesium transport protein CorA
R615_02725	COG2861	carbohydrate metabolic process
R615_02730	COG0793	Belongs to the peptidase S41A family
R615_02735	COG4942	peptidase
R615_02740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
R615_02745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
R615_02750	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
R615_02790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
R615_02820	COG3267	Type II secretory pathway component ExeA
R615_02820	COG3409	Peptidoglycan-binding domain 1 protein
R615_02835	COG1459	type II secretion system
R615_02890	COG2204	response regulator
R615_02910	COG3094	Invasion gene expression up-regulator, SirB
R615_02930	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
R615_02945	COG2119	membrane
R615_02980	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
R615_02985	COG2894	cell division
R615_02990	COG0850	regulation of cytokinetic process
R615_03000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
R615_03005	COG0671	phosphoesterase, PA-phosphatase related
R615_03010	COG0438	transferase activity, transferring glycosyl groups
R615_03055	COG0579	oxidoreductase
R615_03105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
R615_03110	COG2951	lytic endotransglycosylase activity
R615_03115	COG0772	Belongs to the SEDS family
R615_03120	COG0768	penicillin binding
R615_03125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
R615_03140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
R615_03165	COG0586	Pfam SNARE associated Golgi protein
R615_03175	COG3098	single-species biofilm formation
R615_03200	COG1686	Belongs to the peptidase S11 family
R615_03205	COG2921	Belongs to the UPF0250 family
R615_03210	COG0321	lipoyl(octanoyl) transferase activity
R615_03215	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
R615_03235	COG3118	belongs to the thioredoxin family
R615_03245	COG0142	geranyltranstransferase activity
R615_03250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
R615_03255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
R615_03260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
R615_03265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
R615_03275	COG0268	Binds directly to 16S ribosomal RNA
R615_03280	COG0728	peptidoglycan biosynthetic process
R615_03285	COG0196	riboflavin kinase activity
R615_03290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
R615_03295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
R615_03300	COG1047	Peptidyl-prolyl cis-trans
R615_03305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
R615_03360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
R615_03360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
R615_03390	COG0028	Belongs to the TPP enzyme family
R615_03400	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
R615_03405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
R615_03415	COG0151	Belongs to the GarS family
R615_03420	COG0138	bifunctional purine biosynthesis protein purh
R615_03440	COG2264	protein methyltransferase activity
R615_03445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
R615_03455	COG5001	Diguanylate cyclase
R615_03455	COG3300	MHYT domain
R615_03465	COG2863	cytochrome
R615_03480	COG0488	(ABC) transporter
R615_03485	COG3706	GGDEF domain
R615_03505	COG0737	Belongs to the 5'-nucleotidase family
R615_03510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
R615_03515	COG3239	Fatty acid desaturase
R615_03530	COG0741	lytic transglycosylase activity
R615_03535	COG2096	Adenosyltransferase
R615_03540	COG4206	TonB-dependent receptor
R615_03545	COG5002	protein histidine kinase activity
R615_03550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
R615_03560	COG1666	GTP binding
R615_03565	COG2211	Major facilitator Superfamily
R615_03570	COG0587	DNA-directed DNA polymerase activity
R615_03590	COG0583	DNA-binding transcription factor activity
R615_03610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
R615_03625	COG0300	oxidoreductase activity
R615_03640	COG0415	Belongs to the DNA photolyase family
R615_03645	COG0789	Transcriptional regulator
R615_03650	COG3272	Protein of unknown function (DUF1722)
R615_03660	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
R615_03665	COG1960	acyl-CoA dehydrogenase activity
R615_03670	COG1090	epimerase
R615_03720	COG4372	Transposase
R615_03750	COG0069	glutamate synthase activity
R615_03755	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
R615_03775	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
R615_03780	COG0415	Belongs to the DNA photolyase family
R615_03785	COG3046	protein related to deoxyribodipyrimidine photolyase
R615_03795	COG1024	Enoyl-CoA hydratase
R615_03795	COG1250	3-hydroxyacyl-CoA dehydrogenase
R615_03800	COG1960	acyl-CoA dehydrogenase activity
R615_03805	COG1454	alcohol dehydrogenase
R615_03810	COG0824	Thioesterase
R615_03815	COG1012	belongs to the aldehyde dehydrogenase family
R615_03835	COG3128	pkhd-type hydroxylase
R615_03850	COG3706	GGDEF domain
R615_03850	COG4251	negative regulation of phosphorylation
R615_03850	COG5001	Diguanylate cyclase
R615_03850	COG2203	Gaf domain
R615_03865	COG3550	peptidyl-serine autophosphorylation
R615_03890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
R615_03900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
R615_03905	COG0733	neurotransmitter:sodium symporter activity
R615_03915	COG2914	Belongs to the UPF0125 (RnfH) family
R615_03930	COG0497	DNA recombination
R615_03935	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
R615_03940	COG0443	Heat shock 70 kDa protein
R615_03945	COG0484	heat shock protein binding
R615_03950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
R615_03965	COG0505	Belongs to the CarA family
R615_03975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
R615_03990	COG1607	acyl-coa hydrolase
R615_04005	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
R615_04010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
R615_04015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
R615_04020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
R615_04025	COG0149	triose-phosphate isomerase activity
R615_04040	COG0779	Required for maturation of 30S ribosomal subunits
R615_04045	COG0195	Participates in both transcription termination and antitermination
R615_04050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
R615_04055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
R615_04060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
R615_04065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
R615_04070	COG1185	polyribonucleotide nucleotidyltransferase activity
R615_04080	COG1404	Belongs to the peptidase S8 family
R615_04100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
R615_04105	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
R615_04135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
R615_04145	COG1322	Protein conserved in bacteria
R615_04150	COG3706	GGDEF domain
R615_04155	COG4106	trans-aconitate 2-methyltransferase activity
R615_04160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
R615_04165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
R615_04180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
R615_04185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
R615_04200	COG0519	Catalyzes the synthesis of GMP from XMP
R615_04200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
R615_04205	COG3530	Putative quorum-sensing-regulated virulence factor
R615_04215	COG5001	Diguanylate cyclase
R615_04215	COG3300	MHYT domain
R615_04220	COG3123	guanosine phosphorylase activity
R615_04225	COG0513	Belongs to the DEAD box helicase family
R615_04245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
R615_04275	COG5002	protein histidine kinase activity
R615_04275	COG0784	Response regulator, receiver
R615_04275	COG2198	Histidine kinase
R615_04280	COG3706	GGDEF domain
R615_04280	COG0745	RESPONSE REGULATOR receiver
R615_04290	COG0625	glutathione transferase activity
R615_04295	COG0625	glutathione transferase activity
R615_04305	COG2207	Transcriptional regulator
R615_04310	COG4303	Ethanolamine ammonia lyase large subunit
R615_04320	COG0531	amino acid
R615_04340	COG0210	DNA helicase
R615_04365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
R615_04375	COG4191	Histidine kinase
R615_04380	COG0023	Translation Initiation Factor
R615_04400	COG0590	tRNA wobble adenosine to inosine editing
R615_04430	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
R615_04445	COG4372	Transposase
R615_04470	COG0175	sulfate reduction
R615_04490	COG1283	sodium-dependent phosphate transmembrane transporter activity
R615_04510	COG0228	four-way junction DNA binding
R615_04515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
R615_04520	COG0336	Belongs to the RNA methyltransferase TrmD family
R615_04525	COG0335	large ribosomal subunit rRNA binding
R615_04530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
R615_04535	COG0564	pseudouridine synthase activity
R615_04540	COG2267	carboxylic ester hydrolase activity
R615_04550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
R615_04550	COG4651	solute:proton antiporter activity
R615_04560	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
R615_04585	COG0492	ferredoxin-NADP+ reductase activity
R615_04595	COG0393	Putative heavy-metal-binding
R615_04600	COG0393	Putative heavy-metal-binding
R615_04605	COG1960	acyl-CoA dehydrogenase activity
R615_04700	COG0582	viral genome integration into host DNA
R615_04725	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
R615_04730	COG0835	chemotaxis
R615_04730	COG0784	Response regulator, receiver
R615_04740	COG1815	bacterial-type flagellum-dependent cell motility
R615_04745	COG1558	bacterial-type flagellum-dependent cell motility
R615_04750	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
R615_04755	COG1749	Flagellar hook protein flgE
R615_04760	COG4787	bacterial-type flagellum-dependent cell motility
R615_04765	COG4786	Flagellar basal body rod
R615_04770	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
R615_04785	COG1706	bacterial-type flagellum-dependent cell motility
R615_04805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
R615_04820	COG0529	Catalyzes the synthesis of activated sulfate
R615_04870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
R615_04875	COG1051	belongs to the nudix hydrolase family
R615_04930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
R615_04995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
R615_05015	COG1596	polysaccharide export
R615_05020	COG0489	protein tyrosine kinase activity
R615_05040	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
R615_05055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
R615_05060	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
R615_05065	COG2890	protein-(glutamine-N5) methyltransferase activity
R615_05075	COG2204	response regulator
R615_05085	COG4191	Histidine kinase
R615_05090	COG2204	response regulator
R615_05095	COG1677	Flagellar hook-basal body complex protein FliE
R615_05135	COG0643	Histidine kinase
R615_05135	COG2198	Histidine kinase
R615_05155	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
R615_05160	COG2201	protein-glutamate methylesterase activity
R615_05210	COG1987	bacterial-type flagellum assembly
R615_05215	COG1684	flagellar biosynthetic protein fliR
R615_05220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
R615_05240	COG0455	bacterial-type flagellum organization
R615_05255	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
R615_05260	COG0643	Histidine kinase
R615_05260	COG2198	Histidine kinase
R615_05265	COG2201	protein-glutamate methylesterase activity
R615_05270	COG1192	Involved in chromosome partitioning
R615_05285	COG0835	chemotaxis
R615_05320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
R615_05325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
R615_05330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
R615_05335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
R615_05340	COG0745	RESPONSE REGULATOR receiver
R615_05345	COG2205	protein histidine kinase activity
R615_05350	COG0583	DNA-binding transcription factor activity
R615_05355	COG0840	transmembrane signaling receptor activity
R615_05360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
R615_05365	COG3706	GGDEF domain
R615_05365	COG0745	RESPONSE REGULATOR receiver
R615_05370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
R615_05375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
R615_05380	COG0189	ligase activity
R615_05405	COG0602	queuosine metabolic process
R615_05410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
R615_05440	COG0513	Belongs to the DEAD box helicase family
R615_05445	COG1741	Belongs to the pirin family
R615_05450	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
R615_05455	COG0024	Methionine aminopeptidase
R615_05460	COG0052	Belongs to the universal ribosomal protein uS2 family
R615_05465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
R615_05470	COG0528	UMP kinase activity
R615_05475	COG0233	cytoplasmic translational termination
R615_05480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
R615_05515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
R615_05520	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
R615_05525	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
R615_05530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
R615_05540	COG2081	HI0933 family
R615_05575	COG1017	nitric oxide dioxygenase activity
R615_05575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
R615_05590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
R615_05595	COG1024	Enoyl-CoA hydratase
R615_05600	COG0439	Biotin carboxylase
R615_05615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
R615_05620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
R615_05640	COG0864	Transcriptional regulator
R615_05660	COG0436	Aminotransferase
R615_05685	COG1187	pseudouridine synthase activity
R615_05690	COG0676	glucose-6-phosphate 1-epimerase activity
R615_05695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
R615_05705	COG3112	Uncharacterised protein family (UPF0231)
R615_05710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
R615_05715	COG0418	dihydroorotase activity
R615_05725	COG0137	argininosuccinate synthase activity
R615_05745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
R615_05750	COG0210	DNA helicase
R615_05770	COG4372	Transposase
R615_05790	COG0564	pseudouridine synthase activity
R615_05820	COG1451	nucleotide metabolic process
R615_05835	COG0583	DNA-binding transcription factor activity
R615_05865	COG0346	lactoylglutathione lyase activity
R615_05870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
R615_05880	COG2885	chlorophyll binding
R615_05885	COG2171	N-acyltransferase activity
R615_05890	COG1393	Belongs to the ArsC family
R615_05895	COG2205	protein histidine kinase activity
R615_05895	COG5002	protein histidine kinase activity
R615_05895	COG0784	Response regulator, receiver
R615_05905	COG0400	carboxylic ester hydrolase activity
R615_05925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
R615_05930	COG0719	Fe-S assembly protein
R615_05935	COG0396	ATPase activity
R615_05940	COG0719	Fe-S assembly protein
R615_05955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
R615_05995	COG1285	pathogenesis
R615_06000	COG0443	Heat shock 70 kDa protein
R615_06045	COG1393	Belongs to the ArsC family
R615_06050	COG1295	ribonuclease BN
R615_06090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
R615_06110	COG3243	poly(R)-hydroxyalkanoic acid synthase
R615_06125	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
R615_06125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
R615_06135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
R615_06150	COG2350	Protein conserved in bacteria
R615_06155	COG2917	probably involved in intracellular septation
R615_06160	COG0613	PHP domain protein
R615_06165	COG0009	L-threonylcarbamoyladenylate synthase
R615_06170	COG0180	Tryptophanyl-tRNA synthetase
R615_06175	COG0180	Tryptophanyl-tRNA synthetase
R615_06185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
R615_06195	COG3706	GGDEF domain
R615_06200	COG1028	Short-chain dehydrogenase reductase Sdr
R615_06215	COG0402	S-adenosylhomocysteine deaminase activity
R615_06230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
R615_06240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
R615_06245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
R615_06250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
R615_06260	COG0776	regulation of translation
R615_06265	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
R615_06280	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
R615_06285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
R615_06325	COG0463	Glycosyl transferase, family 2
R615_06325	COG1216	Glycosyl transferase, family 2
R615_06335	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
R615_06355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
R615_06380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
R615_06385	COG0717	Belongs to the dCTP deaminase family
R615_06395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
R615_06420	COG0556	nucleotide-excision repair
R615_06435	COG5001	Diguanylate cyclase
R615_06435	COG4251	negative regulation of phosphorylation
R615_06435	COG2203	Gaf domain
R615_06435	COG3706	GGDEF domain
R615_06455	COG0737	Belongs to the 5'-nucleotidase family
R615_06460	COG4585	Histidine kinase
R615_06465	COG2197	response regulator
R615_06475	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
R615_06515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
R615_06555	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
R615_06560	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
R615_06570	COG3639	organic phosphonate transmembrane transporter activity
R615_06600	COG1045	serine acetyltransferase
R615_06615	COG0318	PFAM AMP-dependent synthetase and ligase
R615_06620	COG1215	transferase activity, transferring glycosyl groups
R615_06640	COG1045	serine acetyltransferase
R615_06710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
R615_06715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
R615_06720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
R615_06725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
R615_06730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
R615_06735	COG0072	phenylalanine-tRNA ligase activity
R615_06740	COG0776	regulation of translation
R615_06760	COG1028	Short-chain dehydrogenase reductase Sdr
R615_06780	COG1942	4-Oxalocrotonate Tautomerase
R615_06785	COG4628	conserved protein (DUF2132)
R615_06830	COG0577	efflux transmembrane transporter activity
R615_06830	COG1136	(ABC) transporter
R615_06835	COG1136	(ABC) transporter
R615_06835	COG0577	efflux transmembrane transporter activity
R615_06840	COG0577	efflux transmembrane transporter activity
R615_06840	COG1136	(ABC) transporter
R615_06845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
R615_06860	COG0500	methyltransferase
R615_06865	COG3122	Protein conserved in bacteria
R615_06870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
R615_06875	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
R615_06880	COG2202	Pas domain
R615_06880	COG2205	protein histidine kinase activity
R615_06890	COG1960	acyl-CoA dehydrogenase activity
R615_06895	COG1960	acyl-CoA dehydrogenase activity
R615_06900	COG3022	response to hydroperoxide
R615_06920	COG0583	DNA-binding transcription factor activity
R615_06930	COG0542	response to heat
R615_06940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
R615_06945	COG0632	four-way junction helicase activity
R615_06950	COG2255	four-way junction helicase activity
R615_06955	COG0824	Thioesterase
R615_06975	COG0823	Involved in the tonB-independent uptake of proteins
R615_06980	COG2885	chlorophyll binding
R615_06985	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
R615_07000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
R615_07005	COG4783	chaperone-mediated protein folding
R615_07020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
R615_07035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
R615_07055	COG0545	Peptidyl-prolyl cis-trans isomerase
R615_07085	COG0363	glucosamine-6-phosphate deaminase activity
R615_07095	COG0800	Aldolase
R615_07115	COG1215	transferase activity, transferring glycosyl groups
R615_07120	COG3769	mannosylglycerate metabolic process
R615_07125	COG0572	uridine kinase
R615_07130	COG1605	Chorismate mutase
R615_07130	COG0077	Prephenate dehydratase
R615_07135	COG0784	Response regulator, receiver
R615_07135	COG2205	protein histidine kinase activity
R615_07135	COG5002	protein histidine kinase activity
R615_07170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
R615_07185	COG2022	thiamine diphosphate biosynthetic process
R615_07190	COG0352	thiamine-phosphate diphosphorylase activity
R615_07195	COG0326	Molecular chaperone. Has ATPase activity
R615_07220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
R615_07230	COG1376	ErfK ybiS ycfS ynhG family protein
R615_07235	COG1472	Belongs to the glycosyl hydrolase 3 family
R615_07260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
R615_07270	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
R615_07275	COG1805	sodium ion transport
R615_07295	COG2871	sodium ion transport
R615_07305	COG3179	chitinase
R615_07310	COG0300	oxidoreductase activity
R615_07460	COG3268	Saccharopine dehydrogenase
R615_07465	COG0640	Transcriptional regulator
R615_07475	COG0798	PFAM Bile acid sodium symporter
R615_07490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
R615_07490	COG0506	proline dehydrogenase activity
R615_07490	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
R615_07505	COG0513	Belongs to the DEAD box helicase family
R615_07510	COG4681	YaeQ
R615_07535	COG3239	Fatty acid desaturase
R615_07545	COG0318	PFAM AMP-dependent synthetase and ligase
R615_07550	COG1960	acyl-CoA dehydrogenase activity
R615_07560	COG3047	cAMP biosynthetic process
R615_07570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
R615_07575	COG0302	gtp cyclohydrolase
R615_07580	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
R615_07585	COG3706	GGDEF domain
R615_07605	COG0640	Transcriptional regulator
R615_07635	COG0271	Belongs to the BolA IbaG family
R615_07665	COG0484	heat shock protein binding
R615_07675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
R615_07685	COG0037	tRNA processing
R615_07695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
R615_07725	COG2010	Cytochrome c
R615_07740	COG3278	Belongs to the heme-copper respiratory oxidase family
R615_07795	COG3920	Histidine kinase
R615_07810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
R615_07815	COG0745	RESPONSE REGULATOR receiver
R615_07815	COG3706	GGDEF domain
R615_07820	COG2205	protein histidine kinase activity
R615_07820	COG0784	Response regulator, receiver
R615_07820	COG5002	protein histidine kinase activity
R615_07865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
R615_07880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
R615_07925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
R615_07965	COG1049	propionate catabolic process, 2-methylcitrate cycle
R615_07975	COG3383	formate dehydrogenase (NAD+) activity
R615_07980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
R615_07990	COG0436	Aminotransferase
R615_07995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
R615_08000	COG0386	Belongs to the glutathione peroxidase family
R615_08005	COG1846	Transcriptional regulator
R615_08040	COG1131	(ABC) transporter
R615_08045	COG0842	Transport permease protein
R615_08050	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
R615_08050	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
R615_08090	COG0840	transmembrane signaling receptor activity
R615_08095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
R615_08110	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
R615_08120	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
R615_08135	COG2850	peptidyl-arginine hydroxylation
R615_08165	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
R615_08180	COG3267	Type II secretory pathway component ExeA
R615_08180	COG3409	Peptidoglycan-binding domain 1 protein
R615_08190	COG1199	ATP-dependent helicase activity
R615_08205	COG4591	ABC-type transport system involved in lipoprotein release permease component
R615_08225	COG0811	peptide transport
R615_08230	COG0848	biopolymer transport protein
R615_08235	COG1132	(ABC) transporter
R615_08240	COG1663	tetraacyldisaccharide 4'-kinase activity
R615_08245	COG2835	tetraacyldisaccharide 4'-kinase activity
R615_08250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
R615_08260	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
R615_08265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
R615_08270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
R615_08275	COG0215	cysteine-tRNA ligase activity
R615_08295	COG2860	membrane
R615_08305	COG3177	Filamentation induced by cAMP protein fic
R615_08315	COG2133	pyrroloquinoline quinone binding
R615_08320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
R615_08345	COG0544	peptidyl-prolyl cis-trans isomerase activity
R615_08350	COG0740	serine-type endopeptidase activity
R615_08355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
R615_08360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
R615_08375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
R615_08390	COG0741	lytic transglycosylase activity
R615_08390	COG1388	LysM domain
R615_08400	COG0328	RNA-DNA hybrid ribonuclease activity
R615_08405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
R615_08410	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
R615_08430	COG0616	signal peptide processing
R615_08435	COG0604	alcohol dehydrogenase
R615_08440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
R615_08440	COG4651	solute:proton antiporter activity
R615_08450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
R615_08455	COG0584	glycerophosphoryl diester phosphodiesterase
R615_08460	COG0534	Mate efflux family protein
R615_08470	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
R615_08470	COG0316	Belongs to the HesB IscA family
R615_08480	COG0745	RESPONSE REGULATOR receiver
R615_08490	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
R615_08500	COG2062	phosphohistidine phosphatase, SixA
R615_08520	COG0564	pseudouridine synthase activity
R615_08565	COG1477	protein flavinylation
R615_08575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
R615_08590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
R615_08595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
R615_08605	COG2915	High frequency lysogenization protein hflD homolog
R615_08620	COG1187	pseudouridine synthase activity
R615_08630	COG1278	Cold shock
R615_08635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
R615_08640	COG0542	response to heat
R615_08645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
R615_08650	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
R615_08655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
R615_08660	COG1674	ftsk spoiiie
R615_08665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
R615_08670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
R615_08675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
R615_08680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
R615_08700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
R615_08705	COG2920	part of a sulfur-relay system
R615_08715	COG2923	Belongs to the DsrF TusC family
R615_08720	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
R615_08730	COG0123	including yeast histone deacetylase and acetoin utilization protein
R615_08740	COG2197	response regulator
R615_08745	COG0322	excinuclease ABC activity
R615_08750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
R615_08835	COG3156	type II secretion system protein K
R615_08855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
R615_08865	COG2326	polyphosphate kinase activity
R615_08875	COG0723	plastoquinol--plastocyanin reductase activity
R615_08880	COG0058	SHG alpha-glucan phosphorylase activity
R615_08915	COG2217	Heavy metal translocating P-type atpase
R615_08970	COG2132	Multicopper oxidase
R615_08980	COG5002	protein histidine kinase activity
R615_09005	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
R615_09010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
R615_09070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
R615_09100	COG0672	)-iron permease
R615_09105	COG0789	Transcriptional regulator
R615_09110	COG1230	cation diffusion facilitator family transporter
R615_09140	COG1230	cation diffusion facilitator family transporter
R615_09145	COG1742	UPF0060 membrane protein
R615_09170	COG1028	Short-chain dehydrogenase reductase Sdr
R615_09180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
R615_09180	COG0301	tRNA thio-modification
R615_09200	COG0708	Exodeoxyribonuclease III
R615_09220	COG0848	biopolymer transport protein
R615_09225	COG0811	peptide transport
R615_09230	COG0811	peptide transport
R615_09245	COG1104	cysteine desulfurase activity
R615_09260	COG0666	response to abiotic stimulus
R615_09285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
R615_09290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
R615_09295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
R615_09300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
R615_09305	COG1028	Short-chain dehydrogenase reductase Sdr
R615_09315	COG0416	fatty acid biosynthetic process
R615_09320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
R615_09330	COG0616	signal peptide processing
R615_09335	COG0546	phosphoglycolate phosphatase activity
R615_09345	COG1530	ribonuclease E activity
R615_09355	COG3706	GGDEF domain
R615_09355	COG0745	RESPONSE REGULATOR receiver
R615_09365	COG0372	Belongs to the citrate synthase family
R615_09370	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
R615_09375	COG2186	Transcriptional regulator
R615_09405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
R615_09440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
R615_09445	COG0560	Phosphoserine phosphatase
R615_09460	COG0730	response to heat
R615_09470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
R615_09475	COG2853	Lipoprotein
R615_09485	COG3220	belongs to the UPF0276 family
R615_09495	COG1643	Atp-dependent helicase
R615_09500	COG0318	PFAM AMP-dependent synthetase and ligase
R615_09505	COG2030	dehydratase
R615_09595	COG2983	Belongs to the UPF0260 family
R615_09600	COG3100	YcgL domain-containing protein
R615_09610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
R615_09615	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
R615_09665	COG0824	Thioesterase
R615_09670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
R615_09675	COG5265	(ABC) transporter
R615_09705	COG3101	peptidyl-lysine hydroxylation
R615_09710	COG0534	Mate efflux family protein
R615_09720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
R615_09770	COG0667	Aldo Keto reductase
R615_09775	COG0840	transmembrane signaling receptor activity
R615_09800	COG0714	Associated with various cellular activities
R615_09815	COG1286	toxin biosynthetic process
R615_09825	COG0285	dihydrofolate synthase activity
R615_09830	COG0159	tryptophan synthase activity
R615_09835	COG0133	tryptophan synthase activity
R615_09840	COG0135	phosphoribosylanthranilate isomerase activity
R615_09855	COG0101	tRNA pseudouridine synthase activity
R615_09870	COG0473	3-isopropylmalate dehydrogenase activity
R615_09880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
R615_09890	COG0589	response to stress
R615_09895	COG0280	phosphate acetyltransferase
R615_09905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
R615_09910	COG0006	proline dipeptidase activity
R615_09915	COG1012	belongs to the aldehyde dehydrogenase family
R615_09920	COG0431	NADPH-dependent FMN reductase
R615_09935	COG0589	response to stress
R615_09945	COG2801	Transposase and inactivated derivatives
R615_09985	COG0045	succinate-CoA ligase (ADP-forming) activity
R615_09990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
R615_10010	COG1053	succinate dehydrogenase
R615_10015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
R615_10020	COG2009	succinate dehydrogenase
R615_10030	COG2084	Dehydrogenase
R615_10040	COG0835	chemotaxis
R615_10040	COG0784	Response regulator, receiver
R615_10045	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
R615_10050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
R615_10060	COG0859	PFAM glycosyl transferase family 9
R615_10070	COG0463	Glycosyl transferase, family 2
R615_10090	COG0439	Biotin carboxylase
R615_10100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
R615_10105	COG1074	ATP-dependent DNA helicase activity
R615_10110	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
R615_10155	COG0686	Belongs to the AlaDH PNT family
R615_10165	COG4773	Receptor
R615_10195	COG3707	response regulator
R615_10200	COG1116	anion transmembrane transporter activity
R615_10200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
R615_10205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
R615_10215	COG1116	anion transmembrane transporter activity
R615_10225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
R615_10240	COG2223	nitrite transmembrane transporter activity
R615_10245	COG2146	nitrite reductase [NAD(P)H] activity
R615_10250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
R615_10255	COG0243	molybdopterin cofactor binding
R615_10260	COG1648	precorrin-2 dehydrogenase activity
R615_10260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
R615_10325	COG2818	Glycosylase
R615_10335	COG0442	prolyl-tRNA aminoacylation
R615_10360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
R615_10365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
R615_10370	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
R615_10375	COG0579	oxidoreductase
R615_10440	COG2205	protein histidine kinase activity
R615_10445	COG1902	pentaerythritol trinitrate reductase activity
R615_10445	COG0446	pyridine nucleotide-disulphide oxidoreductase
R615_10450	COG0489	protein tyrosine kinase activity
R615_10455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
R615_10465	COG4172	Belongs to the ABC transporter superfamily
R615_10470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
R615_10475	COG0601	transmembrane transport
R615_10490	COG4657	Part of a membrane complex involved in electron transport
R615_10495	COG2878	Part of a membrane complex involved in electron transport
R615_10500	COG4656	Part of a membrane complex involved in electron transport
R615_10505	COG4658	electron transport chain
R615_10510	COG4659	FMN binding
R615_10515	COG4660	Part of a membrane complex involved in electron transport
R615_10555	COG1309	transcriptional regulator
R615_10570	COG0840	transmembrane signaling receptor activity
R615_10575	COG2963	transposase activity
R615_10580	COG2801	Transposase and inactivated derivatives
R615_10620	COG2801	Transposase and inactivated derivatives
R615_10640	COG0154	amidase activity
R615_10655	COG1187	pseudouridine synthase activity
R615_10660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
R615_10675	COG0789	Transcriptional regulator
R615_10695	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
R615_10755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
R615_10760	COG5002	protein histidine kinase activity
R615_10815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
R615_10820	COG2226	methyltransferase
R615_10835	COG0525	valine-tRNA ligase activity
R615_10900	COG4807	Protein conserved in bacteria
R615_10915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
R615_10920	COG0525	valine-tRNA ligase activity
R615_10940	COG0583	DNA-binding transcription factor activity
R615_10950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
R615_10965	COG1862	Preprotein translocase
R615_10995	COG3706	GGDEF domain
R615_10995	COG4251	negative regulation of phosphorylation
R615_10995	COG2203	Gaf domain
R615_10995	COG5001	Diguanylate cyclase
R615_11010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
R615_11030	COG1028	Short-chain dehydrogenase reductase Sdr
R615_11040	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
R615_11045	COG2945	thiolester hydrolase activity
R615_11050	COG0175	sulfate reduction
R615_11085	COG0259	pyridoxamine-phosphate oxidase activity
R615_11095	COG0795	lipopolysaccharide-transporting ATPase activity
R615_11100	COG0795	lipopolysaccharide-transporting ATPase activity
R615_11110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
R615_11125	COG2885	chlorophyll binding
R615_11145	COG0519	Catalyzes the synthesis of GMP from XMP
R615_11145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
R615_11175	COG0739	heme binding
R615_11190	COG1946	Acyl-CoA thioesterase
R615_11195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
R615_11200	COG0513	Belongs to the DEAD box helicase family
R615_11210	COG1741	Belongs to the pirin family
R615_11225	COG2818	Glycosylase
R615_11235	COG2925	Exonuclease
R615_11260	COG2223	nitrite transmembrane transporter activity
R615_11270	COG1028	Short-chain dehydrogenase reductase Sdr
R615_11275	COG0517	IMP dehydrogenase activity
R615_11275	COG0516	GMP reductase activity
R615_11285	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
R615_11295	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
R615_11295	COG3264	Mechanosensitive ion channel
R615_11315	COG1643	Atp-dependent helicase
R615_11320	COG0730	response to heat
R615_11325	COG2801	Transposase and inactivated derivatives
R615_11335	COG4115	mRNA cleavage
R615_11340	COG2161	toxin-antitoxin pair type II binding
R615_11345	COG0783	Belongs to the Dps family
R615_11375	COG0307	riboflavin synthase, alpha
R615_11385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
R615_11430	COG2755	lipolytic protein G-D-S-L family
R615_11430	COG0657	acetylesterase activity
R615_11435	COG0004	ammonium transporteR
R615_11445	COG3130	regulation of translation
R615_11470	COG0714	Associated with various cellular activities
R615_11485	COG2304	oxidoreductase activity
R615_11520	COG0519	Catalyzes the synthesis of GMP from XMP
R615_11520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
R615_11525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
R615_11530	COG3115	cell septum assembly
R615_11535	COG1196	nuclear chromosome segregation
R615_11545	COG3239	Fatty acid desaturase
R615_11570	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
R615_11580	COG1902	pentaerythritol trinitrate reductase activity
R615_11615	COG3153	acetyltransferase
R615_11670	COG0183	Belongs to the thiolase family
R615_11695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
R615_11745	COG2409	Drug exporters of the RND superfamily
R615_11760	COG0308	aminopeptidase N
R615_11775	COG0705	Rhomboid family
R615_11780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
R615_11785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
R615_11860	COG0494	nUDIX hydrolase
R615_11885	COG0681	Belongs to the peptidase S26 family
R615_11890	COG0596	Alpha beta hydrolase
R615_11895	COG1253	flavin adenine dinucleotide binding
R615_11910	COG2095	MarC family integral membrane protein
R615_11925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
R615_11950	COG2200	EAL domain
R615_11950	COG2202	Pas domain
R615_11950	COG2199	diguanylate cyclase activity
R615_11980	COG0784	Response regulator, receiver
R615_11980	COG2205	protein histidine kinase activity
R615_11990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
R615_12040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
R615_12065	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
R615_12070	COG4133	protoheme IX ABC transporter activity
R615_12090	COG0252	asparaginase activity
R615_12130	COG2203	Gaf domain
R615_12130	COG5001	Diguanylate cyclase
R615_12130	COG3706	GGDEF domain
R615_12130	COG4251	negative regulation of phosphorylation
R615_12145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
R615_12155	COG0204	Acyl-transferase
R615_12165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
R615_12180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
R615_12220	COG2205	protein histidine kinase activity
R615_12220	COG0784	Response regulator, receiver
R615_12220	COG5002	protein histidine kinase activity
R615_12230	COG2207	Transcriptional regulator
R615_12230	COG4753	response regulator
R615_12240	COG1025	Belongs to the peptidase M16 family
R615_12255	COG0300	oxidoreductase activity
R615_12285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
R615_12290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
R615_12300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
R615_12315	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
R615_12340	COG2264	protein methyltransferase activity
R615_12360	COG0084	hydrolase, TatD family'
R615_12375	COG2264	protein methyltransferase activity
R615_12395	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
R615_12415	COG1278	Cold shock
R615_12420	COG3313	Fe-S protein
R615_12425	COG3622	Belongs to the hyi family
R615_12430	COG2084	Dehydrogenase
R615_12435	COG1639	'signal transduction protein
R615_12450	COG4067	protein conserved in archaea
R615_12450	COG0189	ligase activity
R615_12455	COG2193	ferroxidase activity
R615_12505	COG0432	Pfam Uncharacterised protein family UPF0047
R615_12515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
R615_12525	COG4536	flavin adenine dinucleotide binding
R615_12530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
R615_12530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
R615_12535	COG0829	nickel cation binding
R615_12540	COG0831	urea catabolic process
R615_12545	COG0832	Belongs to the urease beta subunit family
R615_12550	COG0804	urea catabolic process
R615_12555	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
R615_12560	COG0830	nickel cation binding
R615_12565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
R615_12600	COG1960	acyl-CoA dehydrogenase activity
R615_12605	COG1250	3-hydroxyacyl-CoA dehydrogenase
R615_12605	COG1024	Enoyl-CoA hydratase
R615_12610	COG1160	GTP binding
R615_12625	COG0124	histidyl-tRNA synthetase
R615_12640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
R615_12645	COG0105	UTP biosynthetic process
R615_12685	COG2900	Belongs to the SlyX family
R615_12690	COG2937	Belongs to the GPAT DAPAT family
R615_12695	COG0742	ribosomal rna small subunit methyltransferase
R615_12700	COG1968	undecaprenyl-diphosphatase activity
R615_12705	COG1214	PFAM Peptidase M22, glycoprotease
R615_12715	COG0563	adenylate kinase activity
R615_12720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
R615_12725	COG3956	TIGRFAM MazG family protein
R615_12730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
R615_12735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
R615_12745	COG5002	protein histidine kinase activity
R615_12745	COG0784	Response regulator, receiver
R615_12745	COG2205	protein histidine kinase activity
R615_12750	COG0736	holo-[acyl-carrier-protein] synthase activity
R615_12760	COG1381	Involved in DNA repair and RecF pathway recombination
R615_12765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
R615_12770	COG0571	ribonuclease III activity
R615_12780	COG0481	GTPase activity
R615_12785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
R615_12860	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
R615_12865	COG0848	biopolymer transport protein
R615_12870	COG0811	peptide transport
R615_12875	COG0811	peptide transport
R615_12895	COG0583	DNA-binding transcription factor activity
R615_12910	COG2067	long-chain fatty acid transport protein
R615_12920	COG0500	methyltransferase
R615_12940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
R615_12940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
R615_12950	COG0019	diaminopimelate decarboxylase activity
R615_12955	COG1132	(ABC) transporter
R615_12980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
R615_12985	COG2308	Evidence 4 Homologs of previously reported genes of
R615_13090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
R615_13105	COG2003	Belongs to the UPF0758 family
R615_13110	COG1476	TRANSCRIPTIONal
R615_13135	COG1597	lipid kinase activity
R615_13145	COG1846	Transcriptional regulator
R615_13185	COG1397	ADP-ribosylglycohydrolase
R615_13195	COG3107	peptidoglycan biosynthetic process
R615_13200	COG0792	nuclease activity
R615_13210	COG0598	Magnesium transport protein CorA
R615_13220	COG0446	pyridine nucleotide-disulphide oxidoreductase
R615_13230	COG2890	protein-(glutamine-N5) methyltransferase activity
R615_13235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
R615_13240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
R615_13250	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
R615_13255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
R615_13265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
R615_13270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
R615_13275	COG0193	aminoacyl-tRNA hydrolase activity
R615_13285	COG2814	Major facilitator Superfamily
R615_13315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
R615_13320	COG1702	phosphate starvation-inducible protein PhoH
R615_13330	COG4535	Mg2 and Co2 transporter CorC
R615_13335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
R615_13360	COG0653	protein targeting
R615_13365	COG0739	heme binding
R615_13370	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
R615_13385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
R615_13390	COG1181	Belongs to the D-alanine--D-alanine ligase family
R615_13395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
R615_13400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
R615_13405	COG0772	Belongs to the SEDS family
R615_13415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
R615_13420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
R615_13425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
R615_13440	COG0275	rRNA processing
R615_13490	COG0156	8-amino-7-oxononanoate synthase activity
R615_13495	COG2226	methyltransferase
R615_13500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
R615_13515	COG0450	alkyl hydroperoxide reductase
R615_13535	COG0404	The glycine cleavage system catalyzes the degradation of glycine
R615_13540	COG0509	glycine decarboxylation via glycine cleavage system
R615_13545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
R615_13545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
R615_13550	COG5001	Diguanylate cyclase
R615_13550	COG3300	MHYT domain
R615_13555	COG5001	Diguanylate cyclase
R615_13555	COG2203	Gaf domain
R615_13555	COG4251	negative regulation of phosphorylation
R615_13555	COG3706	GGDEF domain
R615_13575	COG0840	transmembrane signaling receptor activity
R615_13590	COG0366	Alpha amylase catalytic
R615_13595	COG0579	oxidoreductase
R615_13600	COG2996	Protein conserved in bacteria
R615_13615	COG4628	conserved protein (DUF2132)
R615_13620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
R615_13625	COG0488	(ABC) transporter
R615_13630	COG0840	transmembrane signaling receptor activity
R615_13645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
R615_13675	COG0189	ligase activity
R615_13695	COG0084	hydrolase, TatD family'
R615_13705	COG0513	Belongs to the DEAD box helicase family
R615_13715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
R615_13720	COG1129	ABC transporter
R615_13720	COG0842	Transport permease protein
R615_13725	COG0842	Transport permease protein
R615_13735	COG4628	conserved protein (DUF2132)
R615_13800	COG2072	flavoprotein involved in K transport
R615_13820	COG2268	Band 7 protein
R615_13825	COG1024	Enoyl-CoA hydratase
R615_13825	COG1250	3-hydroxyacyl-CoA dehydrogenase
R615_13830	COG0183	Belongs to the thiolase family
R615_13845	COG0789	Transcriptional regulator
R615_13850	COG1028	Short-chain dehydrogenase reductase Sdr
R615_13865	COG0840	transmembrane signaling receptor activity
R615_13870	COG0508	dehydrogenase complex catalyzes the overall conversion of
R615_13880	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
R615_13890	COG1492	cobalamin metabolic process
R615_13895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
R615_13905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
R615_13920	COG1940	carbohydrate kinase activity
R615_13930	COG3023	N-Acetylmuramoyl-L-alanine amidase
R615_13935	COG1115	amino acid carrier protein
R615_13970	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
R615_13975	COG0237	dephospho-CoA kinase activity
R615_13980	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
R615_13990	COG2197	response regulator
R615_14005	COG1730	sister chromatid segregation
R615_14035	COG2203	Gaf domain
R615_14035	COG3706	GGDEF domain
R615_14035	COG4251	negative regulation of phosphorylation
R615_14035	COG5001	Diguanylate cyclase
R615_14040	COG1881	PFAM PEBP family protein
R615_14050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
R615_14050	COG0678	peroxiredoxin activity
R615_14075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
R615_14080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
R615_14115	COG1366	Belongs to the anti-sigma-factor antagonist family
R615_14120	COG0789	Transcriptional regulator
R615_14125	COG2813	Specifically methylates the guanine in position
R615_14130	COG2814	Major facilitator Superfamily
R615_14135	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
R615_14140	COG1765	OsmC-like protein
R615_14150	COG0134	indole-3-glycerol-phosphate synthase activity
R615_14155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
R615_14185	COG1309	transcriptional regulator
R615_14190	COG1960	acyl-CoA dehydrogenase activity
R615_14195	COG1960	acyl-CoA dehydrogenase activity
R615_14210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
R615_14215	COG1040	competence protein
R615_14240	COG2267	carboxylic ester hydrolase activity
R615_14245	COG0183	Belongs to the thiolase family
R615_14265	COG1611	Belongs to the LOG family
R615_14270	COG1785	Belongs to the alkaline phosphatase family
R615_14275	COG2010	Cytochrome c
R615_14290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
R615_14310	COG2154	pterin-4-alpha-carbinolamine dehydratase
R615_14350	COG0424	maF-like protein
R615_14370	COG2827	Endonuclease containing a URI domain
R615_14375	COG1272	protein, Hemolysin III
R615_14385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
R615_14390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
R615_14395	COG3178	'Phosphotransferase
R615_14400	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
R615_14405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
R615_14410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
R615_14415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
R615_14425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
R615_14430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
R615_14435	COG2766	serine protein kinase
R615_14440	COG2718	Belongs to the UPF0229 family
R615_14445	COG2719	SpoVR family
R615_14480	COG0617	tRNA 3'-terminal CCA addition
R615_14485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
R615_14485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
R615_14490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
R615_14495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
R615_14500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
R615_14505	COG1610	YqeY-like protein
R615_14510	COG0358	DNA primase activity
R615_14525	COG2203	Gaf domain
R615_14525	COG3706	GGDEF domain
R615_14525	COG4251	negative regulation of phosphorylation
R615_14525	COG5001	Diguanylate cyclase
R615_14545	COG1024	Enoyl-CoA hydratase
R615_14570	COG1671	Belongs to the UPF0178 family
R615_14590	COG3706	GGDEF domain
R615_14590	COG0745	RESPONSE REGULATOR receiver
R615_14600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
R615_14630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
R615_14635	COG0527	aspartate kinase activity
R615_14640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
R615_14660	COG2267	carboxylic ester hydrolase activity
R615_14665	COG1252	NADH dehydrogenase
R615_14675	COG2137	regulation of response to DNA damage stimulus
R615_14680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
R615_14710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
R615_14715	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
R615_14725	COG0179	Fumarylacetoacetate (FAA) hydrolase
R615_14735	COG0488	(ABC) transporter
R615_14745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
R615_14770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
R615_14775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
R615_14775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
R615_14790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
R615_14800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
R615_14845	COG2072	flavoprotein involved in K transport
R615_14855	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
R615_14860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
R615_14865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
R615_14875	COG0564	pseudouridine synthase activity
R615_14880	COG2267	carboxylic ester hydrolase activity
R615_14890	COG2267	carboxylic ester hydrolase activity
R615_14920	COG0288	reversible hydration of carbon dioxide
R615_14925	COG5016	pyruvate
R615_14925	COG0511	ligase activity, forming carbon-carbon bonds
R615_14930	COG0439	Biotin carboxylase
R615_14955	COG0546	phosphoglycolate phosphatase activity
R615_14985	COG2409	Drug exporters of the RND superfamily
R615_15005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
R615_15020	COG3634	alkyl hydroperoxide reductase activity
R615_15025	COG0450	alkyl hydroperoxide reductase
R615_15045	COG0668	transmembrane transport
R615_15050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
R615_15055	COG0557	exoribonuclease II activity
R615_15065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
R615_15090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
R615_15100	COG0254	rRNA binding
R615_15105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
R615_15110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
R615_15115	COG2738	Putative neutral zinc metallopeptidase
R615_15120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
R615_15125	COG2204	response regulator
R615_15130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
R615_15130	COG4191	Histidine kinase
R615_15140	COG0142	geranyltranstransferase activity
R615_15150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
R615_15155	COG1360	Flagellar Motor Protein
R615_15165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
R615_15180	COG1320	monovalent cation:proton antiporter activity
R615_15185	COG2212	antiporter activity
R615_15195	COG0651	ATP synthesis coupled electron transport
R615_15200	COG1006	Multisubunit Na H antiporter MnhC subunit
R615_15205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
R615_15205	COG2111	Na H antiporter
R615_15210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
R615_15220	COG0493	'glutamate synthase
R615_15225	COG0070	glutamate synthase
R615_15225	COG0069	glutamate synthase activity
R615_15225	COG0067	glutamate synthase
R615_15235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
R615_15240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
R615_15275	COG0277	FAD linked oxidase domain protein
R615_15280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
R615_15285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
R615_15290	COG1119	ATPase activity
R615_15295	COG0537	adenosine 5'-monophosphoramidase activity
R615_15300	COG3706	GGDEF domain
R615_15300	COG0745	RESPONSE REGULATOR receiver
R615_15340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
R615_15345	COG1183	phosphatidylcholine synthase activity
R615_15350	COG0583	DNA-binding transcription factor activity
R615_15360	COG5002	protein histidine kinase activity
R615_15360	COG3447	MASE1 domain protein
R615_15360	COG5001	Diguanylate cyclase
R615_15365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
R615_15370	COG2166	iron-sulfur cluster assembly
R615_15400	COG0126	phosphoglycerate kinase activity
R615_15405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
R615_15425	COG1012	belongs to the aldehyde dehydrogenase family
R615_15445	COG0402	S-adenosylhomocysteine deaminase activity
R615_15455	COG2351	hydroxyisourate hydrolase activity
R615_15465	COG4266	Belongs to the allantoicase family
R615_15475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
R615_15500	COG1957	nucleoside hydrolase
R615_15505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
R615_15520	COG0811	peptide transport
R615_15525	COG0811	peptide transport
R615_15530	COG0848	biopolymer transport protein
R615_15550	COG1309	transcriptional regulator
R615_15570	COG1064	alcohol dehydrogenase
R615_15590	COG2315	Protein conserved in bacteria
R615_15595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
R615_15650	COG0305	Participates in initiation and elongation during chromosome replication
R615_15655	COG0359	binds to the 23S rRNA
R615_15665	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
R615_15670	COG0360	Binds together with S18 to 16S ribosomal RNA
R615_15705	COG0523	cobalamin synthesis protein
R615_15720	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
R615_15735	COG2205	protein histidine kinase activity
R615_15740	COG0745	RESPONSE REGULATOR receiver
R615_15750	COG0517	IMP dehydrogenase activity
R615_15775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
R615_15815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
R615_15820	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
R615_15825	COG0735	belongs to the Fur family
R615_15835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
R615_15845	COG0534	Mate efflux family protein
R615_15935	COG1061	Type III restriction enzyme res subunit
R615_15945	COG0534	Mate efflux family protein
R615_15955	COG0583	DNA-binding transcription factor activity
R615_15960	COG3038	cytochrome b561
R615_15965	COG2353	YceI-like domain
R615_15980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
R615_16005	COG4890	Cyd operon protein YbgT
R615_16010	COG1294	oxidase, subunit
R615_16025	COG2199	diguanylate cyclase activity
R615_16025	COG2200	EAL domain
R615_16055	COG0203	ribosomal protein L17
R615_16060	COG0202	RNA polymerase activity
R615_16065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
R615_16070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
R615_16075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
R615_16085	COG0200	Binds to the 23S rRNA
R615_16090	COG1841	ribosomal large subunit assembly
R615_16095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
R615_16105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
R615_16110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
R615_16115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
R615_16120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
R615_16125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
R615_16130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
R615_16135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
R615_16140	COG0255	Belongs to the universal ribosomal protein uL29 family
R615_16150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
R615_16155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
R615_16160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
R615_16165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
R615_16170	COG0089	rRNA binding
R615_16175	COG0088	Forms part of the polypeptide exit tunnel
R615_16185	COG0051	transcription antitermination factor activity, RNA binding
R615_16190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
R615_16195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
R615_16200	COG0049	tRNA binding
R615_16205	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
R615_16215	COG0085	RNA polymerase activity
R615_16220	COG0222	ribosome binding
R615_16225	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
R615_16230	COG0081	regulation of translation
R615_16235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
R615_16255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
R615_16260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
R615_16265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
R615_16290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
R615_16295	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
R615_16295	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
R615_16300	COG4953	penicillin-binding protein 1C
R615_16305	COG2373	Large extracellular alpha-helical protein
R615_16330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
R615_16350	COG2169	Transcriptional regulator
R615_16350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
R615_16380	COG4716	Myosin-crossreactive antigen
R615_16395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
R615_16425	COG1404	Belongs to the peptidase S8 family
R615_16455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
R615_16460	COG0746	molybdenum cofactor guanylyltransferase activity
R615_16465	COG0521	Mo-molybdopterin cofactor biosynthetic process
R615_16470	COG0315	cyclic pyranopterin monophosphate synthase activity
R615_16475	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
R615_16480	COG0314	molybdopterin synthase activity
R615_16495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
R615_16510	COG1872	DUF167
R615_16515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
R615_16520	COG2813	Specifically methylates the guanine in position
R615_16520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
R615_16530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
R615_16540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
R615_16545	COG4667	esterase of the alpha-beta hydrolase superfamily
R615_16555	COG0527	aspartate kinase activity
R615_16560	COG1917	Cupin 2, conserved barrel domain protein
R615_16565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
R615_16575	COG1846	Transcriptional regulator
R615_16630	COG0204	Acyl-transferase
R615_16635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
R615_16640	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
R615_16665	COG3118	belongs to the thioredoxin family
R615_16675	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
R615_16680	COG0210	DNA helicase
R615_16685	COG1737	Transcriptional regulator
R615_16695	COG0004	ammonium transporteR
R615_16700	COG0347	Belongs to the P(II) protein family
R615_16720	COG0411	ABC transporter
R615_16740	COG1802	Transcriptional regulator
R615_16770	COG3025	triphosphatase activity
R615_16835	COG0730	response to heat
R615_16850	COG3108	Peptidase M15
R615_16855	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
R615_16860	COG0494	nUDIX hydrolase
R615_16885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
R615_16890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
R615_16895	COG0006	proline dipeptidase activity
R615_16915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
R615_16960	COG0281	malic enzyme
R615_16970	COG0745	RESPONSE REGULATOR receiver
R615_16975	COG0628	permease
R615_16990	COG1346	cytolysis
R615_17000	COG0494	nUDIX hydrolase
R615_17005	COG1011	Hydrolase
R615_17010	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
R615_17015	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
R615_17020	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
R615_17025	COG2183	response to ionizing radiation
R615_17030	COG2918	glutathione biosynthetic process
R615_17040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
R615_17080	COG2015	COG2015, Alkyl sulfatase and related hydrolases
R615_17090	COG2832	Protein of unknown function (DUF454)
R615_17135	COG0488	(ABC) transporter
R615_17150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
R615_17155	COG2363	Small membrane protein
R615_17175	COG0668	transmembrane transport
R615_17195	COG2959	enzyme of heme biosynthesis
R615_17205	COG0181	hydroxymethylbilane synthase activity
R615_17220	COG0165	Argininosuccinate lyase
R615_17245	COG2307	Protein conserved in bacteria
R615_17245	COG2308	Evidence 4 Homologs of previously reported genes of
R615_17260	COG2308	Evidence 4 Homologs of previously reported genes of
R615_17280	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
R615_17300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
R615_17305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
R615_17315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
R615_17325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
R615_17335	COG0356	it plays a direct role in the translocation of protons across the membrane
R615_17350	COG1475	DNA binding
R615_17355	COG1192	Involved in chromosome partitioning
R615_17360	COG0357	Ribosomal RNA small subunit methyltransferase G
R615_17390	COG0745	RESPONSE REGULATOR receiver
R615_17395	COG2205	protein histidine kinase activity
R615_17405	COG3002	Belongs to the UPF0753 family
R615_17410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
R615_17415	COG0583	DNA-binding transcription factor activity
R615_17435	COG0445	tRNA wobble uridine modification
R615_17500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
R615_17505	COG0706	membrane insertase activity
R615_17510	COG0594	ribonuclease P activity
R615_17515	COG0230	Belongs to the bacterial ribosomal protein bL34 family