locus-tag class description DY252_00025 ENOG4108JQC penicillin-binding protein 1A DY252_00030 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase DY252_00040 ENOG4105CPQ Dehydrogenase DY252_00045 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_00055 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit DY252_00060 ENOG4107XBN GntR Family Transcriptional Regulator DY252_00070 ENOG4105DEI Mannitol dehydrogenase DY252_00075 ENOG4107SS6 2-dehydro-3-deoxygluconokinase DY252_00125 ENOG4105G47 Methyltransferase, type 11 DY252_00130 ENOG4107RGC Glycosyl transferase, family 2 DY252_00145 ENOG4108JJ6 Type I secretion system ATPase DY252_00155 ENOG4105E2K Glycosyl transferase (Group 1 DY252_00160 ENOG4105EUF amidase EC 3.5.1.4 DY252_00165 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase DY252_00170 ENOG4108JQ6 ABC transporter DY252_00175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY252_00180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY252_00190 ENOG4105MP9 class II Aldolase DY252_00205 ENOG4105C8Y Acetylornithine aminotransferase DY252_00210 ENOG4107S5T Carbohydrate kinase DY252_00215 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) DY252_00220 ENOG4105F5R ABC transporter DY252_00225 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DY252_00230 ENOG4105C2J ABC transporter DY252_00235 ENOG4105D4B ABC, transporter DY252_00240 ENOG4105E98 transcriptional regulator DeoR family DY252_00250 ENOG4105C9F isomerase DY252_00295 ENOG4105W1Y Transcriptional regulator DY252_00305 ENOG4107ZQN disulfide bond DY252_00315 ENOG41080T7 secreted protein DY252_00325 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DY252_00355 ENOG4105KST dependent repressor DY252_00380 ENOG4107QX9 Thiol disulfide interChange protein DY252_00385 ENOG4107ZT5 Thiol disulfide interchange protein DY252_00415 ENOG4107QIV Cytochrome c biogenesis protein DY252_00440 ENOG4105W1Y Transcriptional regulator DY252_00510 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DY252_00545 ENOG4105CVJ phosphoglycerate mutase DY252_00550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_00555 ENOG4108I5D sulfate abc transporter DY252_00565 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_00575 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC DY252_00580 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DY252_00585 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DY252_00590 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DY252_00595 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DY252_00600 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DY252_00605 ENOG4105E39 Enoyl-CoA hydratase DY252_00610 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DY252_00615 ENOG4105EJ9 Membrane DY252_00620 ENOG4105F27 Major Facilitator DY252_00625 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DY252_00635 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) DY252_00640 ENOG4105D07 Signal peptide peptidase, SppA DY252_00645 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DY252_00650 ENOG4105CAT Cytidine monophosphate kinase DY252_00675 ENOG4105CHM Aminotransferase DY252_00685 ENOG4105C5I Dehydrogenase DY252_00690 ENOG4105MP9 class II Aldolase DY252_00710 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DY252_00725 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DY252_00730 ENOG4105F8J Adenylate Guanylate cyclase DY252_00745 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DY252_00750 ENOG4107SDU Methyl-accepting chemotaxis DY252_00755 ENOG4107SDU Methyl-accepting chemotaxis DY252_00760 ENOG4108ZZ3 UPF0260 protein DY252_00785 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) DY252_00795 ENOG4105C1B dTDP-glucose 4-6-dehydratase DY252_00825 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DY252_00865 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DY252_00870 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) DY252_00875 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DY252_00885 ENOG4108IAJ Nad-dependent epimerase dehydratase DY252_00890 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) DY252_00895 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) DY252_00905 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) DY252_00920 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase DY252_00925 ENOG4105DVK Precorrin-2 c20-methyltransferase DY252_00935 ENOG4105CIA precorrin-4 C(11)-methyltransferase DY252_00995 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DY252_01005 ENOG4105EHG Permease protein DY252_01010 ENOG4105E0A ABC, transporter DY252_01015 ENOG4105CPD ethanolamine ammonia-lyase DY252_01020 ENOG4107FQ9 ethanolamine ammonia-lyase DY252_01030 ENOG4108RAC Rubrerythrin DY252_01045 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DY252_01050 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DY252_01055 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DY252_01060 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DY252_01065 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DY252_01070 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DY252_01080 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DY252_01090 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DY252_01095 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DY252_01100 ENOG4108WRK Transcriptional regulator DY252_01105 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) DY252_01110 ENOG4107RCQ (CBS) domain DY252_01115 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DY252_01120 ENOG4105C9A Phoh family DY252_01125 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DY252_01140 ENOG41090R7 Ferric uptake DY252_01155 ENOG41072GX Peptidase M22 Glycoprotease DY252_01160 ENOG4108UQS dipeptidase DY252_01165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_01170 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DY252_01175 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component DY252_01180 ENOG4108JP0 extracellular solute-binding protein family 1 DY252_01190 ENOG4105FKQ transcriptional regulator DY252_01195 ENOG4108302 MgtC SapB transporter DY252_01205 ENOG4105N14 lysine exporter protein LysE YggA DY252_01215 ENOG4105D06 uba thif-type nad fad binding protein DY252_01220 ENOG4105C6T cysteine synthase DY252_01225 ENOG410847I Transcriptional regulator, BadM Rrf2 family DY252_01230 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DY252_01235 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DY252_01250 ENOG4105BZU Histidine kinase DY252_01255 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DY252_01260 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DY252_01265 ENOG4105CPN adenine deaminase DY252_01270 ENOG4108T5G Adenylate DY252_01275 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DY252_01290 ENOG4108154 Acetyltransferase (GNAT) family DY252_01295 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DY252_01300 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DY252_01310 ENOG4105K59 histidine triad (HIT) protein DY252_01330 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase DY252_01340 ENOG4105CBN LysR family transcriptional regulator DY252_01345 ENOG4105CHR reductase DY252_01370 ENOG4105CPC Aldo Keto reductase DY252_01380 ENOG410642W LysR family Transcriptional regulator DY252_01385 ENOG4105C0P Mg chelatase subunit ChlI DY252_01405 ENOG4108SY4 MarR family Transcriptional regulator DY252_01425 ENOG4108U78 Glutathione S-transferase DY252_01435 ENOG4105K8K Cupin 2, conserved barrel DY252_01470 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DY252_01495 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 DY252_01500 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) DY252_01505 ENOG4108YXA Membrane DY252_01510 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DY252_01515 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DY252_01520 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DY252_01525 ENOG4108UHJ MAF-like protein DY252_01530 ENOG4105E2X shikimate dehydrogenase DY252_01535 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DY252_01575 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DY252_01585 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DY252_01600 ENOG4105C7Z Conserved Protein DY252_01610 ENOG4105NZG Ferredoxin DY252_01615 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DY252_01620 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DY252_01625 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) DY252_01630 ENOG4107QJE Chromosome Partitioning Protein DY252_01635 ENOG4105FA0 parb-like partition protein DY252_01660 ENOG4108Z9W Outer membrane porin DY252_01675 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DY252_01685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY252_01690 ENOG4107QJN gtp cyclohydrolase ii DY252_01710 ENOG4105C31 Tryptophanyl-tRNA synthetase DY252_01720 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) DY252_01725 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DY252_01740 ENOG4105C6K Malic enzyme DY252_01745 ENOG4107JPU DY252_01755 ENOG4108UR8 BAX protein DY252_01760 ENOG41083MR nifu domain-containing protein DY252_01775 ENOG4108UVJ appr-1-p processing domain protein DY252_01780 ENOG4105F0N pyrophosphate phospho-hydrolase DY252_01785 ENOG4107R51 Glycosyl transferase, family 2 DY252_01790 ENOG4105CMR udp-glucose 4-epimerase DY252_01795 ENOG4108MGI Transcriptional regulator DY252_01820 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DY252_01825 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DY252_01830 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DY252_01835 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DY252_01840 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DY252_01845 ENOG4105CSA Coproporphyrinogen iii oxidase DY252_01865 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DY252_01880 ENOG4105C2X Arabinose 5-phosphate isomerase DY252_01895 ENOG4108IUZ ABC transporter DY252_01900 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY252_01905 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea DY252_01910 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN DY252_01915 ENOG4105EYM Major Facilitator superfamily DY252_01955 ENOG41082FP UPF0102 protein DY252_01960 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DY252_01970 ENOG4105CSM endonuclease III DY252_01985 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DY252_01990 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DY252_01995 ENOG4105C2M dna polymerase I DY252_02015 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DY252_02025 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DY252_02030 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DY252_02040 ENOG4105DA5 (ABC) transporter DY252_02050 ENOG4105E8V Alpha Beta Hydrolase Fold protein DY252_02070 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DY252_02075 ENOG4105C7K acetolactate synthase DY252_02090 ENOG4105D3Q Sugar transferase DY252_02110 ENOG4105BZU Histidine kinase DY252_02115 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_02120 ENOG4108ZXC Two component transcriptional regulator, luxr family DY252_02135 ENOG4105CBN LysR family transcriptional regulator DY252_02160 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_02170 ENOG4105F38 ABC transporter, permease DY252_02180 ENOG410633P Hydantoin racemase DY252_02185 ENOG4105EMF GntR family transcriptional regulator DY252_02190 ENOG4105HF0 Membrane DY252_02210 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DY252_02240 ENOG4105CHR reductase DY252_02245 ENOG4105CGU Enoyl-CoA hydratase DY252_02255 ENOG4105CSU acyl-Coa dehydrogenase DY252_02275 ENOG4105CEY Amp-dependent synthetase and ligase DY252_02295 ENOG4105MQ2 17 kDa surface antigen DY252_02300 ENOG4105DYB Isoaspartyl dipeptidase DY252_02310 ENOG4105DJ2 Major Facilitator Superfamily DY252_02320 ENOG4107ENK receptor DY252_02325 ENOG4106QJH hemin transport protein DY252_02330 ENOG4107R4I Periplasmic binding protein DY252_02335 ENOG4105EHG Permease protein DY252_02340 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) DY252_02345 ENOG4105ETT transcriptional Regulator, LysR family DY252_02355 ENOG4108JPW Aminotransferase DY252_02360 ENOG4105C26 Dehydrogenase DY252_02365 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DY252_02375 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DY252_02385 ENOG4105BZM domain protein DY252_02395 ENOG4105DJV ribulose-phosphate 3-epimerase DY252_02400 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DY252_02405 ENOG4105ESV Glycosyl transferase, family 4 DY252_02415 ENOG4105E32 cytoplasmic protein DY252_02420 ENOG4105DC1 bifunctional purine biosynthesis protein purh DY252_02440 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DY252_02445 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DY252_02450 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DY252_02455 ENOG4105K9H YciI-like protein DY252_02475 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DY252_02485 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DY252_02490 ENOG4108KXV response regulator DY252_02495 ENOG4105RK9 auxin efflux carrier DY252_02505 ENOG41082BR 50S ribosomal protein L35 DY252_02510 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DY252_02515 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DY252_02520 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DY252_02530 ENOG4105BZU Histidine kinase DY252_02545 ENOG41090KN UPF0303 protein DY252_02555 ENOG4105CAY ferredoxin--nadp reductase DY252_02560 ENOG4105K8N protein family UPF0079, ATPase DY252_02570 ENOG4108S0S Nucleotidyl transferase DY252_02580 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DY252_02585 ENOG4105K63 Thioredoxin DY252_02590 ENOG4105C8Q Methyl-accepting chemotaxis DY252_02615 ENOG4108YZA Nitrogen regulatory protein pii DY252_02635 ENOG4105W49 UPF0434 protein DY252_02645 ENOG4105K63 Thioredoxin DY252_02670 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DY252_02675 ENOG4105C7I Dehydrogenase DY252_02680 ENOG4108IG5 Transcriptional regulator DY252_02685 ENOG4105C1P efflux transporter, rnd family, mfp subunit DY252_02705 ENOG4105D0M Protease HtpX homolog DY252_02715 ENOG4105HFZ Membrane DY252_02730 ENOG4105CV6 ABC transporter, permease DY252_02735 ENOG4108I0Y (ABC) transporter DY252_02740 ENOG4108UJV acyl-CoA thioesterase i DY252_02755 ENOG4105CPC Aldo Keto reductase DY252_02760 ENOG4105EUB pirin domain protein DY252_02780 ENOG4108KTG Membrane protein, drug metabolite transporter DY252_02785 ENOG4108ZT1 Transcriptional regulator DY252_02840 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DY252_02865 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component DY252_02870 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component DY252_02875 ENOG4108JQ5 ABC transporter DY252_02895 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DY252_02905 ENOG4108RG0 uracil-dna glycosylase DY252_02910 ENOG4105KZX Pterin carbinolamine dehydratase DY252_02920 ENOG4108SXK Transporter Drug Metabolite Exporter family DY252_02925 ENOG4105DFI Membrane DY252_02930 ENOG4108SXK Transporter Drug Metabolite Exporter family DY252_02940 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) DY252_02955 ENOG410829K Lysine exporter protein (Lyse ygga) DY252_02975 ENOG4105G9V cytochrome C DY252_02980 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) DY252_02990 ENOG41080BE Methyl-accepting chemotaxis sensory transducer DY252_02995 ENOG4105C1J atp-dependent rna helicase DY252_03010 ENOG4105C1G acyl-Coa dehydrogenase DY252_03015 ENOG4105CHU acetyl-coa acetyltransferase DY252_03035 ENOG4105C1G acyl-Coa dehydrogenase DY252_03040 ENOG4105CAF HipA N-terminal domain protein DY252_03050 ENOG4105E51 psp operon transcriptional activator DY252_03055 ENOG41087YS Phage shock protein A DY252_03090 ENOG4105CI0 Citrate lyase DY252_03095 ENOG4105DJG MaoC domain protein dehydratase DY252_03100 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) DY252_03110 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) DY252_03130 ENOG4105DHG Allantoate amidinohydrolase DY252_03145 ENOG4105VT2 5-hydroxyisourate hydrolase DY252_03155 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding DY252_03165 ENOG4107Y2X deaminase DY252_03170 ENOG4105C2J ABC transporter DY252_03200 ENOG4105C8Q Methyl-accepting chemotaxis DY252_03205 ENOG41067B5 Histone deacetylase superfamily protein DY252_03210 ENOG4105EJC lysr family transcriptional regulator DY252_03220 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DY252_03230 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein DY252_03235 ENOG4105C32 Amino acid ABC transporter (Permease) DY252_03245 ENOG4105C0Z ABC transporter DY252_03250 ENOG4108IV0 ABC, transporter DY252_03255 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DY252_03260 ENOG4108YZ9 Urea amidohydrolase subunit gamma DY252_03265 ENOG4105KI2 Urea amidohydrolase subunit beta DY252_03270 ENOG4105CQM Urea amidohydrolase subunit alpha DY252_03275 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) DY252_03280 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DY252_03285 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) DY252_03295 ENOG4105NPE arsR family transcriptional regulator DY252_03300 ENOG4107ZYJ bioY protein DY252_03305 ENOG4108JJB ABC transporter DY252_03310 ENOG4107QCX Transporter DY252_03325 ENOG4105CC0 LysR family Transcriptional regulator DY252_03335 ENOG4105DTD Dehydrogenase DY252_03365 ENOG4105DG4 malate L-lactate dehydrogenase DY252_03375 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein DY252_03385 ENOG4105D0M Protease HtpX homolog DY252_03390 ENOG4108JJ6 Type I secretion system ATPase DY252_03660 ENOG4107F2M hemolysin-type calcium-binding region DY252_03670 ENOG4105DJT lAO AO transport system ATPase DY252_03690 ENOG4105MIR Phenylalanine 4-monooxygenase DY252_03695 ENOG4108ZRZ Transcriptional regulator (AsnC family) DY252_03705 ENOG4105KK4 UPF0060 membrane protein DY252_03710 ENOG4105BZU Histidine kinase DY252_03715 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_03720 ENOG4105EQD regulatoR DY252_03725 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_03740 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DY252_03745 ENOG4107TF3 peptidylprolyl cis-trans isomerase DY252_03765 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DY252_03795 ENOG4105CEV competence damage-inducible protein DY252_03810 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase DY252_03845 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DY252_03890 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters DY252_03900 ENOG4108W63 CRP FNR family transcriptional regulator DY252_03915 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DY252_03920 ENOG4105CQB FAD linked oxidase domain protein DY252_03925 ENOG4105EU8 FAD linked oxidase domain protein DY252_03930 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DY252_03940 ENOG4105PWN phosphate abc transporter DY252_03945 ENOG4105C8U phosphate abc transporter DY252_03950 ENOG4105E2Z phosphate ABC transporter (Permease DY252_03955 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DY252_03960 ENOG4108UTW Plays a role in the regulation of phosphate uptake DY252_03965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY252_03980 ENOG4105CHR reductase DY252_03985 ENOG4107ZVW dihydroneopterin aldolase DY252_03990 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DY252_03995 ENOG4105C2W permease DY252_04000 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DY252_04005 ENOG4108ZAF Molybdopterin DY252_04020 ENOG4105DWV Homoserine O-trans-acetylase DY252_04025 ENOG4105DWV Homoserine O-trans-acetylase DY252_04035 ENOG4105CIH Imidazole acetol-phosphate transaminase DY252_04045 ENOG4108594 Permease of the drug metabolite transporter DY252_04060 ENOG4105E9Q Acyl-transferase DY252_04075 ENOG4105CAK Cell division ATP-binding protein ftsE DY252_04090 ENOG4108SF5 RNA Polymerase DY252_04095 ENOG4108S3W Anti-feci sigma factor, fecr DY252_04110 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DY252_04115 ENOG4105CH7 arginosuccinase DY252_04120 ENOG4107ZT5 Thiol disulfide interchange protein DY252_04125 ENOG4108RVA ribokinase DY252_04130 ENOG4105CMG Carbohydrate kinase DY252_04135 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DY252_04140 ENOG4105C10 Electron transfer flavoprotein DY252_04145 ENOG4105BZJ Electron transfer flavoprotein DY252_04150 ENOG4108WBT adenosyltransferase DY252_04160 ENOG4108JUA Transcriptional regulator DY252_04165 ENOG4105I5W Transporter DY252_04175 ENOG4105D7T ABC transporter DY252_04180 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) DY252_04185 ENOG4105CYM Glutathione S-transferase DY252_04205 ENOG4105C1G acyl-Coa dehydrogenase DY252_04210 ENOG4105EE1 crotonyl-CoA reductase DY252_04215 ENOG4105RFZ Methylmalonyl-coA mutase DY252_04220 ENOG4108IND Tetr family transcriptional regulator DY252_04225 ENOG4105F6U Short-chain dehydrogenase reductase Sdr DY252_04230 ENOG4105BZU Histidine kinase DY252_04235 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DY252_04240 ENOG4105CUV Homoserine Kinase DY252_04245 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DY252_04255 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DY252_04260 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DY252_04265 ENOG4108EYQ The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DY252_04270 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DY252_04285 ENOG4105EHV domain protein DY252_04290 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) DY252_04295 ENOG4108UJU UPF0301 protein DY252_04315 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DY252_04320 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) DY252_04325 ENOG4107QS1 Cytochrome C Oxidase, Subunit III DY252_04340 ENOG4105CTD carboxy-peptidase DY252_04345 ENOG4105IJJ transcriptional regulator, crp fnr family DY252_04355 ENOG4105C1V Peptidase, M16 DY252_04380 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DY252_04390 ENOG4105CH2 amidohydrolase DY252_04405 ENOG4105C5Q Transcriptional regulator DY252_04415 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DY252_04420 ENOG4105C26 Dehydrogenase DY252_04425 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase DY252_04430 ENOG4108UN4 phage SPO1 DNA polymerase-related protein DY252_04435 ENOG4105E4C Lytic transglycosylase catalytic DY252_04450 ENOG4105KWW Biogenesis protein DY252_04455 ENOG4107QX9 Thiol disulfide interChange protein DY252_04460 ENOG4105DA4 cytochrome c-type biogenesis protein DY252_04465 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) DY252_04475 ENOG41060IM Heme exporter protein DY252_04480 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) DY252_04485 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) DY252_04495 ENOG4105C8J )-transporter DY252_04500 ENOG4105BZU Histidine kinase DY252_04505 ENOG4107QM5 aconitate hydratase DY252_04515 ENOG4105C0Z ABC transporter DY252_04525 ENOG4105C32 Amino acid ABC transporter (Permease) DY252_04540 ENOG4108IV0 ABC, transporter DY252_04545 ENOG4105DZS Phenylacetate-CoA ligase DY252_04550 ENOG4108M4U conserved membrane protein DY252_04560 ENOG4105D65 subunit l DY252_04565 ENOG4108ZE9 Monovalent cation H antiporter subunit C DY252_04570 ENOG4107R4Z monovalent cation h antiporter subunit d DY252_04575 ENOG4105SC1 monovalent cation H antiporter subunit E DY252_04580 ENOG4105W4C monovalent cation H antiporter subunit F DY252_04585 ENOG4105KJM monovalent cation h antiporter subunit g DY252_04590 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DY252_04600 ENOG4108YZN class I peptide chain release factor DY252_04605 ENOG4105WD1 Membrane DY252_04625 ENOG4108VYJ response regulator receiver protein DY252_04630 ENOG4105BZU Histidine kinase DY252_04650 ENOG4105ERG peptidase m48, ste24p DY252_04675 ENOG4105F1J Homogentisate 1,2-dioxygenase DY252_04690 ENOG4105ETT transcriptional Regulator, LysR family DY252_04695 ENOG4105C1G acyl-Coa dehydrogenase DY252_04700 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DY252_04705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_04710 ENOG4105F38 ABC transporter, permease DY252_04715 ENOG4105D38 putrescine abc transporter DY252_04720 ENOG4107RUE extracellular solute-binding protein family 1 DY252_04730 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DY252_04740 ENOG4108WFR AraC Family Transcriptional Regulator DY252_04760 ENOG4105R1U AraC Family Transcriptional Regulator DY252_04770 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic DY252_04805 ENOG4105BZU Histidine kinase DY252_04810 ENOG41063SB peptidase DY252_04820 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) DY252_04825 ENOG4108Z7G MaoC domain protein dehydratase DY252_04830 ENOG4105DTN riboflavin biosynthesis protein ribF DY252_04840 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DY252_04860 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DY252_04875 ENOG4105ER2 Ompa motb domain protein DY252_04880 ENOG4105E14 MotA TolQ exbB proton channel DY252_04890 ENOG4105Q26 Siderophore-interacting protein DY252_04895 ENOG4107RPQ ABC transporter DY252_04900 ENOG4105CC5 ABC transporter DY252_04905 ENOG4105DIK (ABC) transporter DY252_04910 ENOG4105DSE periplasmic solute binding protein DY252_04915 ENOG4105KST dependent repressor DY252_04925 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DY252_04935 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) DY252_04940 ENOG4108REZ Imidazole glycerol phosphate synthase DY252_04945 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DY252_04965 ENOG4105CAQ asparagine synthetase DY252_04970 ENOG4107XU6 Glycosyl transferase (Group 1 DY252_05005 ENOG4105C5E polysaccharide biosynthesis protein DY252_05010 ENOG4105D2T synthase DY252_05015 ENOG4105BZ1 (ABC) transporter DY252_05030 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DY252_05035 ENOG4105K46 50S ribosomal protein l27 DY252_05040 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DY252_05045 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DY252_05050 ENOG4108WRK Transcriptional regulator DY252_05095 ENOG4107R16 Multicopper oxidase DY252_05125 ENOG4107Z1W Fructose transport system kinase DY252_05130 ENOG4105C2J ABC transporter DY252_05135 ENOG4105CNN ABC, transporter DY252_05140 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator DY252_05150 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DY252_05165 ENOG4105EIX cytochrome c1 DY252_05170 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DY252_05175 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DY252_05180 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DY252_05185 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) DY252_05200 ENOG4105CYW agmatinase DY252_05210 ENOG4105ETT transcriptional Regulator, LysR family DY252_05215 ENOG4105CBG Sulfatase DY252_05225 ENOG4107R7Y intracellular protease Pfpi family DY252_05240 ENOG41090HR transcriptional regulator DY252_05245 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY252_05250 ENOG4105E0F Histidine kinase DY252_05260 ENOG4105DP0 ferredoxin-NADP reductase DY252_05265 ENOG4107SDU Methyl-accepting chemotaxis DY252_05270 ENOG4107SDU Methyl-accepting chemotaxis DY252_05275 ENOG4108Z7R Chaperone CsaA DY252_05290 ENOG4105II7 pyrroline-5-carboxylate reductase DY252_05305 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) DY252_05310 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) DY252_05320 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DY252_05330 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DY252_05335 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DY252_05340 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DY252_05345 ENOG4105C3G gtp-binding protein DY252_05350 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DY252_05355 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) DY252_05360 ENOG4105CPQ Dehydrogenase DY252_05370 ENOG4105C5Q Transcriptional regulator DY252_05375 ENOG4105D3R alkyl hydroperoxide reductase DY252_05380 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DY252_05405 ENOG4105E0F Histidine kinase DY252_05420 ENOG4105CHM Aminotransferase DY252_05425 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DY252_05430 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) DY252_05435 ENOG4105C5Q Transcriptional regulator DY252_05440 ENOG4105CFM UPF0317 protein DY252_05455 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_05465 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DY252_05485 ENOG4105RD8 TRAP dicarboxylate transporter DY252_05495 ENOG4108T5G Adenylate DY252_05505 ENOG4105C3M thioredoxin reductase DY252_05510 ENOG4105F7P transcriptional regulator AsnC family DY252_05515 ENOG4105ERG peptidase m48, ste24p DY252_05530 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DY252_05540 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DY252_05545 ENOG4105KTH gatB Yqey DY252_05550 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DY252_05555 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY252_05635 ENOG4105XB7 anti-repressor protein DY252_05775 ENOG4105ED4 portal protein DY252_05815 ENOG4105E3E DY252_05820 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA DY252_05830 ENOG4105CMG Carbohydrate kinase DY252_05835 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 DY252_05845 ENOG4105CPQ Dehydrogenase DY252_05860 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DY252_05870 ENOG4105DKT Transcriptional regulator DY252_05875 ENOG4105CHR reductase DY252_05885 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) DY252_05890 ENOG41077A9 carbonic anhydrase DY252_05895 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DY252_05900 ENOG41076YT nitrate reductase, gamma subunit DY252_05905 ENOG4105R3A Nitrate reductase DY252_05910 ENOG4108IUE nitrate reductase beta subunit DY252_05915 ENOG4105CRU nitrate reductase, alpha subunit DY252_05920 ENOG4105DQQ Major facilitator superfamily MFS_1 DY252_05940 ENOG4105CFP Peptidase U32 DY252_05960 ENOG4105IJJ transcriptional regulator, crp fnr family DY252_05975 ENOG4108T0W nitrous oxide maturation protein NosY DY252_05980 ENOG4105CIG ABC transporter DY252_05990 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) DY252_05995 ENOG4105HEE Binding Domain protein DY252_06005 ENOG4105ETE Transcriptional regulator (LacI family DY252_06025 ENOG4108SV3 Tmao reductase system periplasmic protein tort DY252_06030 ENOG4105C2J ABC transporter DY252_06035 ENOG4105CNN ABC, transporter DY252_06040 ENOG4105C2J ABC transporter DY252_06045 ENOG4105CNN ABC, transporter DY252_06085 ENOG4105DS0 Transcriptional regulator, Crp Fnr family DY252_06120 ENOG41062B0 ABC transporter, permease DY252_06125 ENOG4105C2J ABC transporter DY252_06130 ENOG4105D7K pfkb domain protein DY252_06135 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) DY252_06145 ENOG4105DH8 myo-inositol catabolism DY252_06150 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DY252_06160 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DY252_06165 ENOG4108IFG nitrite reductase, (NAD(P)H) DY252_06175 ENOG4105DQQ Major facilitator superfamily MFS_1 DY252_06185 ENOG4105D7T ABC transporter DY252_06200 ENOG410810E transcriptional regulator, lysR family DY252_06205 ENOG4105DVW rieske (2Fe-2S) DY252_06220 ENOG4108K3Z AraC family transcriptional regulator DY252_06235 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DY252_06245 ENOG4105C5I Dehydrogenase DY252_06255 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) DY252_06260 ENOG4105E0C molybdate abc transporter DY252_06265 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DY252_06275 ENOG41083X2 DNA polymerase III, epsilon subunit DY252_06280 ENOG4105C2X Arabinose 5-phosphate isomerase DY252_06285 ENOG4107QN1 sodium solute DY252_06295 ENOG4105C5H ABC transporter DY252_06305 ENOG410903C (LipO)protein DY252_06310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DY252_06315 ENOG4105SYT Methylenetetrahydrofolate reductase DY252_06320 ENOG4105C3R Methionine synthase DY252_06325 ENOG4105C3R Methionine synthase DY252_06330 ENOG4105C2C drug resistance transporter, Bcr CflA DY252_06345 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DY252_06350 ENOG4105C4R Atp-dependent dna helicase DY252_06355 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DY252_06365 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DY252_06375 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DY252_06385 ENOG4105DC7 peptidase M24 DY252_06390 ENOG4105CPC Aldo Keto reductase DY252_06400 ENOG4106UX7 integral membrane protein DY252_06415 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DY252_06425 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane DY252_06430 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DY252_06435 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DY252_06440 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DY252_06445 ENOG4108UFP Essential cell division protein (By similarity) DY252_06450 ENOG4105CPF Cell wall formation (By similarity) DY252_06455 ENOG4105D4A Cell wall formation (By similarity) DY252_06460 ENOG4105DFU Cell wall formation (By similarity) DY252_06465 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DY252_06475 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DY252_06480 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DY252_06490 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DY252_06495 ENOG4105CJN penicillin-binding protein DY252_06505 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DY252_06510 ENOG4107YUR Cell division protein mraZ DY252_06525 ENOG4107QUT magnesium and cobalt transport protein CorA DY252_06545 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase DY252_06555 ENOG4105C5H ABC transporter DY252_06560 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) DY252_06565 ENOG4108NVR Methyl-accepting chemotaxis DY252_06580 ENOG4105CHR reductase DY252_06595 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_06605 ENOG4105CBC glutamate synthase DY252_06610 ENOG4105YCT UPF0386 protein DY252_06615 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DY252_06630 ENOG4105CQB FAD linked oxidase domain protein DY252_06650 ENOG4108GAE asmA family DY252_06655 ENOG4105CJ3 phosphate transporter DY252_06660 ENOG4105EX9 Membrane DY252_06665 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DY252_06670 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DY252_06675 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DY252_06680 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DY252_06685 ENOG4108X4D Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) DY252_06700 ENOG4105BZU Histidine kinase DY252_06710 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY252_06715 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme DY252_06730 ENOG4108RW8 Universal stress protein F DY252_06740 ENOG4105E6M Sulphatase-modifying factor protein DY252_06750 ENOG4105KNK cytochrome C DY252_06760 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_06770 ENOG4105CH5 extracellular solute-binding protein, family 7 DY252_06785 ENOG4105EAH synthase DY252_06795 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DY252_06805 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit DY252_06810 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DY252_06815 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DY252_06825 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) DY252_06840 ENOG4105CAQ asparagine synthetase DY252_06855 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family DY252_06890 ENOG4105DHP deoxycytidine triphosphate deaminase DY252_06895 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DY252_06900 ENOG4107VBH Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DY252_06905 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DY252_06910 ENOG4108ZTZ UPF0262 protein DY252_06925 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DY252_06930 ENOG4108Z03 MAF-like protein DY252_06935 ENOG4107QQB Ribonuclease E DY252_06940 ENOG4105VYE Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) DY252_06965 ENOG4105CVP deoxyribo-dipyrimidine photolyase DY252_06980 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) DY252_06990 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DY252_07000 ENOG4105C7K acetolactate synthase DY252_07005 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DY252_07010 ENOG4105EAC phosphoserine phosphatase DY252_07030 ENOG4107QJR hflk protein DY252_07035 ENOG4105D1F ATP-binding protein DY252_07045 ENOG4107QIK phosphoribosylformylglycinamidine synthase DY252_07050 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DY252_07060 ENOG4107QPR SAICAR synthetase DY252_07075 ENOG4105WH1 Two component transcriptional regulator luxr family DY252_07080 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DY252_07085 ENOG4108Q5Y Membrane DY252_07090 ENOG4105ETT transcriptional Regulator, LysR family DY252_07095 ENOG4108V1U phospholipid-binding protein DY252_07100 ENOG4105C83 adenylosuccinate lyase DY252_07105 ENOG4108ESY Metal dependent phosphohydrolase DY252_07110 ENOG4108JQ7 (ABC) transporter DY252_07115 ENOG4105C3U ABC transporter DY252_07120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY252_07125 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY252_07130 ENOG4108J59 Extracellular solute-binding protein, family 5 DY252_07145 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase DY252_07150 ENOG4105W5Q DNA repair protein (RadC DY252_07155 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DY252_07160 ENOG4105PW4 Sugar fermentation stimulation protein homolog DY252_07175 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DY252_07185 ENOG4105HEI LysR family (Transcriptional regulator DY252_07190 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DY252_07195 ENOG4105VW4 glutaredoxin 3 DY252_07240 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DY252_07245 ENOG4105CFH Aspartokinase DY252_07250 ENOG4105EA8 2-Nitropropane dioxygenase DY252_07255 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase DY252_07265 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DY252_07275 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DY252_07280 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DY252_07285 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DY252_07305 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DY252_07315 ENOG4108QD6 DY252_07320 ENOG4108IQE Amp-dependent synthetase and ligase DY252_07335 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DY252_07340 ENOG4105W8H transhydrogenase (subunit alpha DY252_07345 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DY252_07365 ENOG4105K5G 30S ribosomal protein S21 DY252_07380 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DY252_07395 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DY252_07400 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DY252_07435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DY252_07445 ENOG4105DUM transcriptional regulator, lysR family DY252_07450 ENOG4105E98 transcriptional regulator DeoR family DY252_07480 ENOG41082FS 50S ribosomal protein L31 DY252_07490 ENOG4105BZ1 (ABC) transporter DY252_07495 ENOG4105DR5 peptidase DY252_07535 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family DY252_07540 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DY252_07545 ENOG4108I5D sulfate abc transporter DY252_07580 ENOG4108JU7 Transcriptional regulator DY252_07585 ENOG4105E2Y ABC, transporter DY252_07590 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DY252_07595 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DY252_07600 ENOG4105GVF (ABC) transporter DY252_07620 ENOG4105CAH Chromate DY252_07625 ENOG4107XVH Transcriptional regulator DY252_07645 ENOG4105FA0 parb-like partition protein DY252_07675 ENOG4105C3F Signal peptidase i DY252_07680 ENOG4105E4C Lytic transglycosylase catalytic DY252_07820 ENOG4105E39 Enoyl-CoA hydratase DY252_07840 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) DY252_07850 ENOG4105C32 Amino acid ABC transporter (Permease) DY252_07860 ENOG4105C2J ABC transporter DY252_07865 ENOG4108IV0 ABC, transporter DY252_07880 ENOG4105D38 putrescine abc transporter DY252_07885 ENOG4105D81 ABC transporter, permease DY252_07890 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_07900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DY252_07905 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY252_07915 ENOG4105EMU Dehydrogenase DY252_07920 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_07925 ENOG4105BZU Histidine kinase DY252_07935 ENOG4105FCD Major Facilitator DY252_07940 ENOG4107RSM transcriptional regulator DY252_07950 ENOG4107QIZ NADH dehydrogenase DY252_07955 ENOG4108JB9 formate dehydrogenase DY252_07965 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DY252_07970 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DY252_07985 ENOG4105JSC dimethylmenaquinone methyltransferase DY252_07995 ENOG4105E2R ROK family DY252_08005 ENOG4105C2J ABC transporter DY252_08010 ENOG4108HWW ABC transporter DY252_08015 ENOG4105DFW ABC transporter DY252_08020 ENOG4105FGE Short-chain dehydrogenase reductase Sdr DY252_08025 ENOG4105C01 Dihydroxy-acid dehydratase DY252_08040 ENOG4105CBC glutamate synthase DY252_08045 ENOG4105M90 Glutamate synthase alpha subunit domain protein DY252_08050 ENOG4105EYU Glutamine amido-transferase DY252_08060 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DY252_08070 ENOG4105E3J oxidoreductase DY252_08085 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DY252_08095 ENOG4105ECQ AraC Family Transcriptional Regulator DY252_08100 ENOG4105DDR sarcosine oxidase (Beta subunit) DY252_08105 ENOG4105WIU sarcosine oxidase delta subunit DY252_08110 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DY252_08125 ENOG4105CWC Acetylornithine deacetylase DY252_08130 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DY252_08145 ENOG41066VF YeeE YedE family protein DY252_08155 ENOG4105C1J atp-dependent rna helicase DY252_08165 ENOG41073TP transcriptional regulator DY252_08175 ENOG4105DRP amino acid AbC transporter DY252_08180 ENOG4105E5Q amino acid AbC transporter DY252_08195 ENOG4108UPT UPF0178 protein DY252_08215 ENOG4105CKI cobalamin synthesis protein DY252_08220 ENOG4105KAV tspo and mbr like protein DY252_08230 ENOG41080BE Methyl-accepting chemotaxis sensory transducer DY252_08235 ENOG4105CYM Glutathione S-transferase DY252_08240 ENOG4105CYM Glutathione S-transferase DY252_08245 ENOG4105CSH Transporter DY252_08250 ENOG4105E2S oxidase) subunit II DY252_08255 ENOG4105BZ9 Cytochrome C oxidase, subunit I DY252_08260 ENOG4105CCU oxidase (Subunit III) DY252_08265 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) DY252_08280 ENOG4108SHQ Glutathione S-transferase DY252_08290 ENOG4105DXX methyltransferase DY252_08295 ENOG4105YA8 Transcriptional regulator DY252_08305 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DY252_08325 ENOG4107GFK fumarate DY252_08335 ENOG4108IPJ Membrane DY252_08345 ENOG4108KK1 membrane protein AbrB duplication DY252_08380 ENOG4105BZU Histidine kinase DY252_08385 ENOG41084GC stage II sporulation protein DY252_08390 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_08415 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DY252_08420 ENOG4105BZU Histidine kinase DY252_08425 ENOG4105CNI cell division protein FtsW DY252_08430 ENOG4105CJN penicillin-binding protein DY252_08440 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DY252_08455 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DY252_08465 ENOG410829K Lysine exporter protein (Lyse ygga) DY252_08480 ENOG4106TD9 Diguanylate cyclase DY252_08495 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DY252_08520 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) DY252_08525 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor DY252_08545 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DY252_08565 ENOG4105CHR reductase DY252_08575 ENOG4105VMP Transcriptional regulator DY252_08590 ENOG4105C59 p-type ATPase DY252_08595 ENOG4107SS6 2-dehydro-3-deoxygluconokinase DY252_08605 ENOG4107RP9 extracellular solute-binding protein, family 3 DY252_08610 ENOG4105DRP amino acid AbC transporter DY252_08615 ENOG4105E5Q amino acid AbC transporter DY252_08625 ENOG4105KME endoribonuclease L-psp DY252_08665 ENOG4105C26 Dehydrogenase DY252_08670 ENOG4105EV9 Alpha Beta Hydrolase DY252_08675 ENOG4107VIJ nudix hydrolase DY252_08695 ENOG4107T3P ABC, transporter DY252_08710 ENOG4105CG3 alpha amylase, catalytic region DY252_08715 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_08720 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DY252_08725 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) DY252_08730 ENOG4105C01 Dihydroxy-acid dehydratase DY252_08735 ENOG4105CHC glucokinase (EC 2.7.1.2) DY252_08740 ENOG4108UHU Aldolase DY252_08755 ENOG4105K6V RNA polymerase DY252_08795 ENOG4105ED1 spovr family DY252_08800 ENOG4106AKX UPF0229 protein DY252_08805 ENOG4105CYN Serine protein kinase DY252_08810 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) DY252_08820 ENOG4108UQ8 endoribonuclease L-psp DY252_08835 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DY252_08840 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ DY252_08845 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_08880 ENOG4105C2N RNA methyltransferase TrmH family group 3 DY252_08895 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DY252_08905 ENOG410683Z Preprotein translocase SecE subunit DY252_08915 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) DY252_08920 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) DY252_08925 ENOG4108VZM 50s ribosomal protein L10 DY252_08930 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DY252_08935 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DY252_08940 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DY252_08945 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DY252_08950 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DY252_08955 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DY252_08960 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DY252_08965 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DY252_08970 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DY252_08975 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DY252_08980 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) DY252_08985 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DY252_08990 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DY252_08995 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DY252_09000 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DY252_09005 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DY252_09010 ENOG41083MP 50s ribosomal protein l29 DY252_09015 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DY252_09020 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DY252_09025 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) DY252_09030 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DY252_09035 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DY252_09040 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DY252_09045 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DY252_09050 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DY252_09055 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DY252_09060 ENOG41084HQ 50S ribosomal protein L30 DY252_09065 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DY252_09070 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DY252_09075 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DY252_09080 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DY252_09085 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DY252_09090 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DY252_09095 ENOG4108ZT0 50S ribosomal protein l17 DY252_09100 ENOG4105C0H protease DY252_09110 ENOG4105D1H recombination factor protein RarA DY252_09115 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DY252_09125 ENOG41082CG Protein CrcB homolog DY252_09130 ENOG4105EI2 Pseudouridine synthase DY252_09140 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DY252_09155 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) DY252_09160 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DY252_09180 ENOG4105BZU Histidine kinase DY252_09190 ENOG4107QX3 carboxylase DY252_09215 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) DY252_09245 ENOG4105CQB FAD linked oxidase domain protein DY252_09250 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DY252_09260 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase DY252_09270 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein DY252_09300 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DY252_09315 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DY252_09325 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DY252_09330 ENOG4108UMI ABC transporter, permease DY252_09335 ENOG4105D01 (LipO)protein DY252_09350 ENOG4105C57 major facilitator superfamily DY252_09365 ENOG4105VDM plasmid maintenance system antidote protein, xre family DY252_09370 ENOG41080ET plasmid maintenance system killer protein DY252_09390 ENOG4105C5H ABC transporter DY252_09395 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DY252_09425 ENOG4108V3E phosphoribosylglycinamide formyltransferase DY252_09430 ENOG4105CXB phosphoribosylaminoimidazole synthetase DY252_09440 ENOG4105C02 permease DY252_09445 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DY252_09450 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) DY252_09455 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) DY252_09465 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) DY252_09525 ENOG4105C9M aspartyl-trna synthetase DY252_09545 ENOG41080HT Transcriptional regulator, arsr family DY252_09570 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DY252_09575 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DY252_09585 ENOG4105CEY Amp-dependent synthetase and ligase DY252_09595 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_09605 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DY252_09610 ENOG4105DRR Transcriptional regulator, GntR family DY252_09615 ENOG4105DX0 Hemolysin A DY252_09650 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DY252_09655 ENOG4107S2Z UPF0761 membrane protein DY252_09670 ENOG4108IQE Amp-dependent synthetase and ligase DY252_09680 ENOG4105EGS Mechanosensitive ion channel DY252_09685 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DY252_09690 ENOG4105MQ2 17 kDa surface antigen DY252_09695 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) DY252_09700 ENOG41080HT Transcriptional regulator, arsr family DY252_09720 ENOG4108RAV Conserved protein DY252_09725 ENOG4106PGW Short-chain dehydrogenase reductase Sdr DY252_09730 ENOG4108YYD acetyltransferase DY252_09745 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DY252_09760 ENOG4105DUM transcriptional regulator, lysR family DY252_09775 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DY252_09785 ENOG4105CHH sulfate transporter DY252_09800 ENOG4105C2C drug resistance transporter, Bcr CflA DY252_09810 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_09815 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ DY252_09820 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DY252_09825 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_09830 ENOG4105CQZ Histidine kinase DY252_09845 ENOG4105D4P Coproporphyrinogen iii oxidase DY252_09860 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DY252_09865 ENOG4105ETT transcriptional Regulator, LysR family DY252_09875 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) DY252_09885 ENOG4107YCY Transcriptional regulator DY252_09895 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) DY252_09915 ENOG4105C8Q Methyl-accepting chemotaxis DY252_09915 ENOG4105C8Q Methyl-accepting chemotaxis DY252_09960 ENOG4105DKK Benzoate DY252_09965 ENOG4105D3R alkyl hydroperoxide reductase DY252_09975 ENOG4106VK6 Flagellar motor protein DY252_09990 ENOG4105ECY inositol monophosphatase DY252_09995 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DY252_10000 ENOG4106HMZ Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DY252_10020 ENOG4105CV1 Transketolase (EC 2.2.1.1) DY252_10040 ENOG4105D48 metallophosphoesterase DY252_10045 ENOG4105C8Q Methyl-accepting chemotaxis DY252_10050 ENOG4105C8Q Methyl-accepting chemotaxis DY252_10055 ENOG4105CDY transcriptional regulatory protein DY252_10060 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) DY252_10065 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DY252_10070 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DY252_10075 ENOG4107YD3 Thioesterase DY252_10080 ENOG4105E02 MotA TolQ exbB proton channel DY252_10085 ENOG4108ZZF transport protein (ExbD) DY252_10095 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) DY252_10100 ENOG4105KCK Peptidoglycan-associated lipoprotein DY252_10110 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DY252_10115 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DY252_10120 ENOG4105EEI dihydropteroate synthase DY252_10125 ENOG4108KXV response regulator DY252_10135 ENOG4105C08 Histidine kinase DY252_10145 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DY252_10150 ENOG4105DWF phosphomethylpyrimidine kinase DY252_10170 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DY252_10185 ENOG4105DCF alanine dehydrogenase DY252_10190 ENOG4108YXU transcriptional regulator AsnC family DY252_10200 ENOG4105D38 putrescine abc transporter DY252_10205 ENOG4105F38 ABC transporter, permease DY252_10210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_10215 ENOG4107RUE extracellular solute-binding protein family 1 DY252_10220 ENOG4105CFQ glutamine synthetase DY252_10230 ENOG4107S8C mandelate racemase muconate lactonizing DY252_10235 ENOG4105EQR Transposase IS116 IS110 IS902 DY252_10270 ENOG4105CMI transporter DY252_10275 ENOG4105CJ1 ABC, transporter DY252_10280 ENOG4105D0S secretion protein (HlyD DY252_10315 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A DY252_10320 ENOG4105VGJ Virulence-associated protein DY252_10335 ENOG4105CQB FAD linked oxidase domain protein DY252_10345 ENOG4105D5K Hemolysin activator protein DY252_10365 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DY252_10375 ENOG4105CYW agmatinase DY252_10380 ENOG4105EVZ LysR family transcriptional regulator DY252_10390 ENOG4105C26 Dehydrogenase DY252_10395 ENOG4106NZI LysR family Transcriptional regulator DY252_10410 ENOG4108UW5 maltose o-acetyltransferase DY252_10430 ENOG4105ECM Sensor protein basS pmrB DY252_10435 ENOG4105ETE Transcriptional regulator (LacI family DY252_10445 ENOG4105E0C molybdate abc transporter DY252_10455 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_10460 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) DY252_10480 ENOG4105ECP epimerase DY252_10490 ENOG4108M0I Transcriptional regulator DY252_10505 ENOG4105DIJ Phosphoethanolamine transferase DY252_10545 ENOG4107RTZ reductase DY252_10570 ENOG4106ECF Uncharacterized protein conserved in bacteria (DUF2155) DY252_10580 ENOG4108YYC ycei family DY252_10585 ENOG4105DS1 cytochrome b561 DY252_10595 ENOG4105C8Q Methyl-accepting chemotaxis DY252_10600 ENOG4105C8Q Methyl-accepting chemotaxis DY252_10600 ENOG4105C8Q Methyl-accepting chemotaxis DY252_10605 ENOG4106KED esterase YpfH DY252_10610 ENOG4107R73 Mate efflux family protein DY252_10615 ENOG4108YXU transcriptional regulator AsnC family DY252_10625 ENOG4105UFH BadM Rrf2 family transcriptional regulator DY252_10630 ENOG4105C1J atp-dependent rna helicase DY252_10650 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DY252_10655 ENOG4105NAU thioesterase Superfamily protein DY252_10665 ENOG4108JQ7 (ABC) transporter DY252_10670 ENOG4105C3U ABC transporter DY252_10675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY252_10680 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY252_10710 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_10715 ENOG4107YWA deoxycytidylate deaminase DY252_10720 ENOG4105CA9 Pyruvate kinase DY252_10740 ENOG4107R7Y intracellular protease Pfpi family DY252_10745 ENOG4105D64 Mechanosensitive ion channel DY252_10750 ENOG4105UYK outer membrane protein a DY252_10760 ENOG4105K4P CoA-binding domain protein DY252_10765 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) DY252_10775 ENOG410829K Lysine exporter protein (Lyse ygga) DY252_10800 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DY252_10805 ENOG4108UJD 30S ribosomal protein S9 DY252_10810 ENOG4105DMF Dehydrogenase DY252_10825 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DY252_10830 ENOG4105FAW cDP-glucose 4,6-dehydratase DY252_10835 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DY252_10870 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DY252_10875 ENOG4108Z0R Transferase DY252_10885 ENOG4106KE4 Dehydrogenase DY252_10890 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class DY252_10900 ENOG4105CHM Aminotransferase DY252_10905 ENOG4105D6E homoserine dehydrogenase DY252_10910 ENOG4105CBT Fructose-1,6-bisphosphatase DY252_10915 ENOG4105CFG Acts as a chaperone (By similarity) DY252_10935 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DY252_10940 ENOG4107R3J Transporter DY252_10960 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DY252_10980 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DY252_10985 ENOG4106VK6 Flagellar motor protein DY252_10990 ENOG4108217 motA TolQ ExbB proton channel DY252_11015 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DY252_11035 ENOG4105C28 cystathionine DY252_11040 ENOG4105MWK D-amino acid dehydrogenase, small subunit DY252_11050 ENOG4105E8R UPF0173 metal-dependent hydrolase DY252_11055 ENOG4107Z6I Thiamine biosynthesis protein DY252_11060 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component DY252_11065 ENOG4108YI8 ABC transporter DY252_11085 ENOG4105DGU Histone deacetylase DY252_11125 ENOG4105CV8 reductase DY252_11130 ENOG4105CKI cobalamin synthesis protein DY252_11135 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DY252_11150 ENOG4105FAV ABC, transporter DY252_11155 ENOG4105C28 cystathionine DY252_11160 ENOG4105C7B Threonine dehydratase DY252_11165 ENOG41082R8 50S ribosomal protein l32 DY252_11180 ENOG4105KHC sulfurtransferase DY252_11185 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DY252_11210 ENOG4105N14 lysine exporter protein LysE YggA DY252_11220 ENOG4105DEN Luciferase family DY252_11235 ENOG4105D94 Major Facilitator Superfamily DY252_11240 ENOG4105C6T cysteine synthase DY252_11245 ENOG41087AY ADP-Ribose pyrophosphatase DY252_11250 ENOG4105BZU Histidine kinase DY252_11260 ENOG4105CIN aminoacyl-histidine dipeptidase DY252_11265 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DY252_11275 ENOG4105YK5 50S ribosomal protein L36 DY252_11315 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) DY252_11330 ENOG4105BZU Histidine kinase DY252_11335 ENOG4105BZU Histidine kinase DY252_11340 ENOG4105BZU Histidine kinase DY252_11355 ENOG4105DAN ATP-dependent protease DY252_11360 ENOG4107SQD Transcriptional regulator, GntR family DY252_11370 ENOG4105C7B Threonine dehydratase DY252_11380 ENOG4105JAB phenazine biosynthesis protein, phzf family DY252_11395 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) DY252_11400 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DY252_11415 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY252_11440 ENOG4108IJ7 Glycine betaine DY252_11445 ENOG4108HQS Glycine betaine DY252_11485 ENOG4105CY0 Metallo-Beta-Lactamase DY252_11495 ENOG4107T8Q Glycosyl transferase (Group 1 DY252_11540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY252_11555 ENOG4105D8G Major Facilitator superfamily DY252_11560 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) DY252_11565 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DY252_11570 ENOG4105KUZ arsenate reductase DY252_11575 ENOG4107YBY Hydrolase DY252_11580 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DY252_11600 ENOG4105W0E 50S ribosomal protein L33 DY252_11605 ENOG4105CN1 protease DY252_11620 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DY252_11625 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DY252_11635 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DY252_11640 ENOG4105CD3 dihydroorotase DY252_11660 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DY252_11665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_11675 ENOG4105F38 ABC transporter, permease DY252_11685 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DY252_11690 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DY252_11695 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DY252_11705 ENOG4105C59 p-type ATPase DY252_11715 ENOG4105CR8 Transcriptional regulator DY252_11720 ENOG4107104 thymidine kinase DY252_11730 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) DY252_11735 ENOG4105F1S paraquat-inducible protein a DY252_11740 ENOG4105DY2 Paraquat-inducible protein b DY252_11755 ENOG4105ECQ AraC Family Transcriptional Regulator DY252_11800 ENOG4105DD7 kinase (PfkB family DY252_11805 ENOG4105CGH 5'-nucleotidase DY252_11810 ENOG4105DIH basic membrane DY252_11815 ENOG4108JQ9 ABC transporter DY252_11835 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) DY252_11840 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DY252_11845 ENOG4105E98 transcriptional regulator DeoR family DY252_11850 ENOG4105DHJ ABC, transporter DY252_11855 ENOG4105CDA abc transporter atp-binding protein DY252_11860 ENOG4105DRP amino acid AbC transporter DY252_11865 ENOG4105EZ7 amino acid ABC transporter DY252_11870 ENOG4107QXX ABC transporter DY252_11875 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DY252_11880 ENOG4108RIR Molybdenum cofactor biosynthesis protein DY252_11900 ENOG41069M3 Transcriptional regulator DY252_11905 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DY252_11940 ENOG4105C22 threonyL-tRNA synthetase DY252_11945 ENOG4105DXI Major Facilitator superfamily DY252_11970 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DY252_11975 ENOG4105D1Q UPF0246 protein DY252_11980 ENOG4107QYG anthranilate phosphoribosyltransferase DY252_11995 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein DY252_12030 ENOG4105CD5 CoA-binding domain protein DY252_12055 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor DY252_12060 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DY252_12065 ENOG4105C72 UPF0176 protein DY252_12070 ENOG4105DFG type I secretion outer membrane protein DY252_12080 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DY252_12085 ENOG4105CRQ synthase (Component I) DY252_12090 ENOG4105DDQ anthranilate synthase DY252_12105 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DY252_12115 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DY252_12120 ENOG4105C75 arginyL-tRNA synthetase DY252_12130 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) DY252_12135 ENOG4108Z4T Peptidase M50 DY252_12140 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DY252_12145 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DY252_12150 ENOG4108IJ6 ABC transporter DY252_12160 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) DY252_12165 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DY252_12170 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DY252_12175 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) DY252_12180 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DY252_12185 ENOG4108K5P (LipO)protein DY252_12210 ENOG4108UIV Protein of unknown function (DUF498/DUF598) DY252_12215 ENOG4107S11 squalene-associated FAD-dependent desaturase DY252_12220 ENOG4105D64 Mechanosensitive ion channel DY252_12235 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) DY252_12245 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DY252_12250 ENOG4105D2N Aldolase DY252_12255 ENOG4105CE4 GlcNAc 6-P deacetylase DY252_12290 ENOG4108UUM single-stranded DNA-binding protein DY252_12305 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY252_12325 ENOG4105CB5 ATP-dependent DNA helicase recG DY252_12345 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DY252_12350 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DY252_12370 ENOG4105E89 ABC transporter DY252_12375 ENOG4108JEH abc transporter atp-binding protein DY252_12380 ENOG4105C8Q Methyl-accepting chemotaxis DY252_12395 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DY252_12405 ENOG4107S90 membrAne DY252_12410 ENOG4105CVE Lytic murein transglycosylase DY252_12420 ENOG4105DZ1 carboxypeptidase DY252_12425 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DY252_12430 ENOG4107QRG dna polymerase iii DY252_12440 ENOG4105F8V Hydrolase, tatD family DY252_12445 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) DY252_12470 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DY252_12520 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DY252_12530 ENOG4105C2D reductase DY252_12535 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DY252_12545 ENOG4105CNN ABC, transporter DY252_12555 ENOG4105C2J ABC transporter DY252_12565 ENOG4105BZU Histidine kinase DY252_12575 ENOG4105DHQ Histidine kinase DY252_12595 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DY252_12620 ENOG4105C8Q Methyl-accepting chemotaxis DY252_12625 ENOG4108KK1 membrane protein AbrB duplication DY252_12630 ENOG4107S7U Sulfide dehydrogenase DY252_12645 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) DY252_12680 ENOG4107QIV Cytochrome c biogenesis protein DY252_12695 ENOG4105CUC YeeE YedE family protein DY252_12715 ENOG4108JPW Aminotransferase DY252_12720 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) DY252_12725 ENOG4105CZK Aspartate kinase DY252_12730 ENOG4105DXN mazG family DY252_12735 ENOG4107TK4 histidinol-phosphate phosphatase DY252_12740 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DY252_12745 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DY252_12755 ENOG4105C1A potassium transporter peripheral membrane DY252_12760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_12790 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DY252_12800 ENOG4105VF7 tolerance protein DY252_12820 ENOG4105WJX transcriptional regulator MERR family DY252_12825 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) DY252_12830 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DY252_12835 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) DY252_12855 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DY252_12860 ENOG4107XZX Involved in the transcription termination process (By similarity) DY252_12865 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DY252_12870 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DY252_12880 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DY252_12885 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) DY252_12890 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DY252_12895 ENOG4108YZG isomerase DY252_12905 ENOG4105CP9 extracellular ligand-binding receptor DY252_12915 ENOG4108IV0 ABC, transporter DY252_12920 ENOG4105C0Z ABC transporter DY252_12925 ENOG4105CF8 branched-chain amino acid ABC transporter, permease DY252_12930 ENOG4105C32 Amino acid ABC transporter (Permease) DY252_12945 ENOG4105E39 Enoyl-CoA hydratase DY252_12950 ENOG4105C1G acyl-Coa dehydrogenase DY252_12960 ENOG4105E98 transcriptional regulator DeoR family DY252_12970 ENOG4105D52 delta-aminolevulinic acid dehydratase DY252_12975 ENOG4105PAD Hydrolase DY252_12985 ENOG4105CEY Amp-dependent synthetase and ligase DY252_12995 ENOG4105C26 Dehydrogenase DY252_13005 ENOG4105C7B Threonine dehydratase DY252_13015 ENOG4107RD7 Flagellar Motor Protein, MotA DY252_13020 ENOG4105ER2 Ompa motb domain protein DY252_13025 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate DY252_13030 ENOG4105CH5 extracellular solute-binding protein, family 7 DY252_13035 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_13045 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DY252_13050 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) DY252_13065 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DY252_13070 ENOG4105C3F Signal peptidase i DY252_13075 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DY252_13080 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) DY252_13095 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) DY252_13110 ENOG4105E50 uracil-dna glycosylase DY252_13115 ENOG4105C9U ATP-dependent DNA helicase RecQ DY252_13120 ENOG4108V06 Glutathione peroxidase DY252_13130 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DY252_13135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DY252_13140 ENOG4105E4C Lytic transglycosylase catalytic DY252_13155 ENOG4105DR5 peptidase DY252_13160 ENOG4108ZAI phosphatidylglycerophosphatase a DY252_13165 ENOG4108I62 cina-like protein DY252_13170 ENOG4108Z1B Cyclase dehydrase DY252_13175 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DY252_13180 ENOG4107QN2 dihydrolipoyl dehydrogenase DY252_13185 ENOG4105C7S Dehydrogenase DY252_13190 ENOG4105CPP Dehydrogenase, E1 component DY252_13195 ENOG4108JYK Dehydrogenase DY252_13205 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DY252_13215 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DY252_13225 ENOG4105CP7 Triose-phosphate isomerase DY252_13230 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DY252_13235 ENOG4105CRQ synthase (Component I) DY252_13240 ENOG4105PXI polysaccharide deacetylase DY252_13245 ENOG4105DDQ anthranilate synthase DY252_13250 ENOG4107QYG anthranilate phosphoribosyltransferase DY252_13255 ENOG4105DK0 Indole-3-glycerol phosphate synthase DY252_13260 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DY252_13265 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DY252_13270 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DY252_13275 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DY252_13280 ENOG4105BZN citrate synthase DY252_13290 ENOG4105E82 cytochrome subunit of dehydrogenase DY252_13295 ENOG4105ETT transcriptional Regulator, LysR family DY252_13305 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DY252_13310 ENOG4105GYT Protein of unknown function (DUF1009) DY252_13315 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DY252_13320 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DY252_13325 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DY252_13335 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane DY252_13340 ENOG4105DZP Membrane-associated zinc metalloprotease DY252_13345 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DY252_13350 ENOG4105KNE Phosphatidate cytidylyltransferase DY252_13355 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DY252_13360 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DY252_13365 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DY252_13370 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) DY252_13375 ENOG4105CE9 30S ribosomal protein S2 DY252_13380 ENOG4105C0B DNA polymerase III (alpha subunit) DY252_13385 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DY252_13395 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DY252_13420 ENOG4107QNB Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DY252_13425 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase DY252_13430 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DY252_13435 ENOG4105C8S subunit m DY252_13440 ENOG4105D65 subunit l DY252_13445 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DY252_13450 ENOG4105DF2 NADH dehydrogenase subunit j DY252_13455 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DY252_13460 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) DY252_13470 ENOG4107QIZ NADH dehydrogenase DY252_13480 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DY252_13485 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DY252_13490 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DY252_13495 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DY252_13505 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DY252_13525 ENOG4105K70 DNA-binding protein DY252_13530 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DY252_13535 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DY252_13540 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DY252_13545 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DY252_13560 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DY252_13565 ENOG4105MWK D-amino acid dehydrogenase, small subunit DY252_13570 ENOG4105BZU Histidine kinase DY252_13585 ENOG4105C59 p-type ATPase DY252_13595 ENOG4108UQY Iron-storage protein DY252_13600 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein DY252_13605 ENOG4105CVP deoxyribo-dipyrimidine photolyase DY252_13630 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component DY252_13635 ENOG4105DRS transport system, permease DY252_13640 ENOG4108IJ9 (ABC) transporter DY252_13645 ENOG4105E0F Histidine kinase DY252_13650 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY252_13660 ENOG4108QDE fad dependent oxidoreductase DY252_13675 ENOG4107QP8 phosphohexose isomerase DY252_13680 ENOG4105D7K pfkb domain protein DY252_13695 ENOG4105CYW agmatinase DY252_13700 ENOG4105C26 Dehydrogenase DY252_13705 ENOG4107VRI Transcriptional regulator DY252_13710 ENOG4105CFQ glutamine synthetase DY252_13715 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY252_13735 ENOG4105CJP fad dependent oxidoreductase DY252_13750 ENOG4105C26 Dehydrogenase DY252_13765 ENOG4108HQS Glycine betaine DY252_13770 ENOG4108IJ7 Glycine betaine DY252_13780 ENOG4108KB2 LysR family Transcriptional regulator DY252_13790 ENOG4105D38 putrescine abc transporter DY252_13800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_13805 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY252_13810 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme DY252_13820 ENOG4105FC8 fad dependent oxidoreductase DY252_13825 ENOG4107S4Y M20 DapE family protein YgeY DY252_13850 ENOG4105CIF Ornithine Cyclodeaminase DY252_13865 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DY252_13870 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_13880 ENOG4106KNT transcriptional regulator DY252_13890 ENOG4105CFU surface antigen DY252_13910 ENOG4105EQR Transposase IS116 IS110 IS902 DY252_13930 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase DY252_13935 ENOG4105CHU acetyl-coa acetyltransferase DY252_13965 ENOG4105F2Z 3-oxoadipate enol-lactonase DY252_13970 ENOG4105DDW LysR family Transcriptional regulator DY252_13985 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_13995 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DY252_14000 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) DY252_14015 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DY252_14025 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY252_14035 ENOG4105Q26 Siderophore-interacting protein DY252_14045 ENOG4105E2A Dehydrogenase DY252_14070 ENOG4108UGV hypoxanthine phosphoribosyltransferase DY252_14090 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase DY252_14095 ENOG4105C3Q Glycosyl transferase, family 2 DY252_14110 ENOG4107QW3 Sucrose phosphorylase DY252_14125 ENOG4108Z7F N-acetyltransferase DY252_14165 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DY252_14180 ENOG4107EJG GntR family transcriptional regulator DY252_14185 ENOG41062B0 ABC transporter, permease DY252_14190 ENOG4107R9N ABC transporter DY252_14195 ENOG4105C2J ABC transporter DY252_14200 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator DY252_14205 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) DY252_14210 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DY252_14215 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_14225 ENOG4105CH5 extracellular solute-binding protein, family 7 DY252_14230 ENOG4105DRR Transcriptional regulator, GntR family DY252_14235 ENOG4105ECQ AraC Family Transcriptional Regulator DY252_14255 ENOG4105E18 UPF0276 protein DY252_14305 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DY252_14320 ENOG4105CD8 aminopeptidase N DY252_14355 ENOG4105BZU Histidine kinase DY252_14365 ENOG4105CH5 extracellular solute-binding protein, family 7 DY252_14370 ENOG4105CH5 extracellular solute-binding protein, family 7 DY252_14380 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DY252_14390 ENOG4105X58 receptor DY252_14395 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DY252_14410 ENOG4109015 Biopolymer transport protein exbD tolR DY252_14435 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) DY252_14440 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DY252_14475 ENOG4105EKE dihydroorotase DY252_14510 ENOG410642W LysR family Transcriptional regulator DY252_14520 ENOG4105CHM Aminotransferase DY252_14530 ENOG4108YZA Nitrogen regulatory protein pii DY252_14535 ENOG4105C5F glutamine synthetase DY252_14540 ENOG4107RDJ Sulfotransferase DY252_14545 ENOG4105BZU Histidine kinase DY252_14555 ENOG4108UKZ OsmC family DY252_14570 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DY252_14575 ENOG4107RDJ Sulfotransferase DY252_14590 ENOG4105BZU Histidine kinase DY252_14605 ENOG4107XBN GntR Family Transcriptional Regulator DY252_14610 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_14615 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_14620 ENOG4108ERU trap dicarboxylate transporter subunit DctP DY252_14625 ENOG4105ECQ AraC Family Transcriptional Regulator DY252_14640 ENOG4107NQ8 LysR family Transcriptional regulator DY252_14645 ENOG4105CP9 extracellular ligand-binding receptor DY252_14650 ENOG4105C0Z ABC transporter DY252_14665 ENOG4105CF8 branched-chain amino acid ABC transporter, permease DY252_14685 ENOG4105BZU Histidine kinase DY252_14725 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DY252_14730 ENOG4105ETU transcriptional activator (TenA DY252_14735 ENOG4105WVQ Fe-S assembly protein IscX DY252_14750 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) DY252_14755 ENOG4108Z4V iron-sulfur cluster assembly DY252_14760 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins DY252_14765 ENOG4105C3J Cysteine desulfurase DY252_14770 ENOG4107QI6 Cysteine desulfurase DY252_14775 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family DY252_14780 ENOG4105D7W serine acetyltransferase DY252_14785 ENOG4105DHZ alpha beta DY252_14790 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DY252_14795 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DY252_14805 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) DY252_14810 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DY252_14820 ENOG4105ED9 Protein of unknown function (DUF455) DY252_14830 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DY252_14865 ENOG4108JQC penicillin-binding protein 1A DY252_14870 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DY252_14875 ENOG4105C03 ribonuclease DY252_14900 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DY252_14905 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DY252_14910 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DY252_14915 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein DY252_14920 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DY252_14925 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) DY252_14935 ENOG4108JQ1 Dehydrogenase DY252_14945 ENOG4105C8Q Methyl-accepting chemotaxis DY252_14965 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) DY252_14980 ENOG4105DZ1 carboxypeptidase DY252_14990 ENOG4105C6Y Udp-glucose 6-dehydrogenase DY252_15000 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DY252_15010 ENOG4107QJE Chromosome Partitioning Protein DY252_15020 ENOG4105D5U fad dependent oxidoreductase DY252_15025 ENOG4105GSQ TM1410 hypothetical-related protein DY252_15035 ENOG4107R37 Glutamate dehydrogenase DY252_15060 ENOG41082WC Transport-associated protein DY252_15075 ENOG4105EW9 transcriptional regulator AsnC family DY252_15090 ENOG4107QX3 carboxylase DY252_15095 ENOG4108UKI Enoyl-CoA hydratase DY252_15105 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DY252_15135 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DY252_15160 ENOG4105CSR polyphosphate kinase 2 DY252_15165 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DY252_15170 ENOG4105CN1 protease DY252_15175 ENOG4105CSU acyl-Coa dehydrogenase DY252_15190 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) DY252_15195 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DY252_15200 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) DY252_15205 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DY252_15210 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DY252_15215 ENOG4105DSJ YicC domain protein DY252_15220 ENOG4107FW0 short-chain dehydrogenase reductase DY252_15225 ENOG4105HHA aminodeoxychorismate lyase DY252_15230 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DY252_15235 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DY252_15245 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DY252_15250 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DY252_15255 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DY252_15270 ENOG4105CDU Replicative dna helicase DY252_15275 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DY252_15285 ENOG4105DHJ ABC, transporter DY252_15300 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase DY252_15305 ENOG4105UBK short-chain dehydrogenase reductase DY252_15340 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DY252_15375 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DY252_15405 ENOG4105E3B Multicopper oxidase DY252_15460 ENOG4105W1Y Transcriptional regulator DY252_15470 ENOG4105DD5 Flagellar motor switch protein DY252_15475 ENOG4105C6T cysteine synthase DY252_15480 ENOG4105MYT Heat shock protein DY252_15485 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DY252_15490 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DY252_15495 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DY252_15505 ENOG4105W1Y Transcriptional regulator DY252_15535 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DY252_15560 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DY252_15565 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DY252_15575 ENOG4107RNG ABC transporter DY252_15585 ENOG4105DFW ABC transporter DY252_15600 ENOG4105C7H Helicase, RecD TraA family DY252_15610 ENOG4105E0X reductase DY252_15620 ENOG4108TGR phosphatase DY252_15625 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DY252_15630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_15640 ENOG4107RUE extracellular solute-binding protein family 1 DY252_15645 ENOG4105E98 transcriptional regulator DeoR family DY252_15725 ENOG4108Q35 Adenylate DY252_15730 ENOG4105E0F Histidine kinase DY252_15735 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY252_15755 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DY252_15760 ENOG4105CAQ asparagine synthetase DY252_15765 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DY252_15770 ENOG4105C26 Dehydrogenase DY252_15780 ENOG4105HMI Membrane DY252_15785 ENOG4105DUM transcriptional regulator, lysR family DY252_15790 ENOG4105C4M (Ubiquinol oxidase) subunit I DY252_15795 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DY252_15805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DY252_15815 ENOG4105C11 sulfate adenylyltransferase), subunit 2 DY252_15835 ENOG4108T9J Cdp-alcohol phosphatidyltransferase DY252_15850 ENOG4105VC4 domain protein DY252_15865 ENOG4108RTU Aldolase DY252_15870 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 DY252_15880 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) DY252_15955 ENOG4105CTU Proline racemase DY252_15960 ENOG41073TP transcriptional regulator DY252_15970 ENOG4105MWK D-amino acid dehydrogenase, small subunit DY252_15975 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DY252_15990 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DY252_16000 ENOG4105C26 Dehydrogenase DY252_16030 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DY252_16035 ENOG4108IJ9 (ABC) transporter DY252_16050 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component DY252_16070 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DY252_16080 ENOG4105CBN LysR family transcriptional regulator DY252_16085 ENOG4105CHR reductase DY252_16095 ENOG4105CD3 dihydroorotase DY252_16105 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DY252_16110 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DY252_16125 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY252_16130 ENOG4108R86 Transcriptional regulator DY252_16140 ENOG4105CE7 Amidase, hydantoinase carbamoylase family DY252_16145 ENOG4107SJI Dehydrogenase DY252_16150 ENOG4105BZ8 glutamate synthase DY252_16155 ENOG4105NAU thioesterase Superfamily protein DY252_16160 ENOG4105DER m42 family DY252_16170 ENOG4108JQ7 (ABC) transporter DY252_16180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY252_16185 ENOG4105DEF Extracellular solute-binding protein, family 5 DY252_16205 ENOG4105BZG amino acid carrier protein DY252_16210 ENOG4105CFP Peptidase U32 DY252_16225 ENOG4107R3E Citrate transporter DY252_16250 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DY252_16255 ENOG4105E0A ABC, transporter DY252_16265 ENOG4105J76 Periplasmic binding protein DY252_16270 ENOG4105S6R Iron-hydroxamate transporter permease subunit DY252_16300 ENOG4105E9Z Nad-dependent epimerase dehydratase DY252_16305 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_16315 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DY252_16320 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase DY252_16330 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DY252_16335 ENOG4105JXH GntR family transcriptional regulator DY252_16340 ENOG4108ZKT aldose 1-epimerase DY252_16345 ENOG4107YCY Transcriptional regulator DY252_16350 ENOG4107URF beta-phospho-glucomutase DY252_16355 ENOG4105EF1 ribulokinase DY252_16360 ENOG4105BZS acriflavin resistance protein DY252_16365 ENOG4105C1P efflux transporter, rnd family, mfp subunit DY252_16380 ENOG4105E0K tonB-dependent siderophore receptor DY252_16390 ENOG4108KPJ rna polymerase sigma factor DY252_16410 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DY252_16425 ENOG410642W LysR family Transcriptional regulator DY252_16430 ENOG4105DFI Membrane DY252_16465 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) DY252_16470 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DY252_16495 ENOG4105JQN Transcriptional regulator DY252_16500 ENOG4105JAB phenazine biosynthesis protein, phzf family DY252_16530 ENOG4105VT3 DNA binding domain protein, excisionase family DY252_16665 ENOG4105BZU Histidine kinase DY252_16700 ENOG4105DK7 lysyl-tRNA synthetase DY252_16705 ENOG4105BZU Histidine kinase DY252_16710 ENOG4105BZU Histidine kinase DY252_16730 ENOG4105K56 Transcriptional regulator DY252_16740 ENOG4108ZHJ Organic hydroperoxide resistance protein DY252_16755 ENOG4105W39 Membrane DY252_16765 ENOG4108VP3 Lysine exporter protein (LysE YggA) DY252_16770 ENOG4106AXJ AraC family transcriptional regulator DY252_16775 ENOG4105DVT helicase DY252_16795 ENOG4105C59 p-type ATPase DY252_16800 ENOG4108YK4 Acid-resistance membrane protein DY252_16835 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DY252_16850 ENOG41069P5 Protein slyX homolog DY252_16865 ENOG4105DCM major facilitator superfamily DY252_16880 ENOG4105CC0 LysR family Transcriptional regulator DY252_16885 ENOG4105CQ7 ATP-dependent helicase DY252_16955 ENOG4107SBE Glycosyl transferase (Group 1 DY252_16975 ENOG4105C8T Leucyl-tRNA synthetase DY252_17005 ENOG4105I03 Flagellin DY252_17010 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DY252_17020 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DY252_17025 ENOG4107SPB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DY252_17080 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme DY252_17095 ENOG4108URH decarboxylase DY252_17105 ENOG4108JU3 Alkyl hydroperoxide reductase DY252_17110 ENOG4105E98 transcriptional regulator DeoR family DY252_17115 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_17130 ENOG4105DRS transport system, permease DY252_17135 ENOG4105SKE transcriptional Regulator LysR family DY252_17150 ENOG4105CA0 peroxidase DY252_17160 ENOG4105EUZ Beta-lactamase domain protein DY252_17185 ENOG4105JAB phenazine biosynthesis protein, phzf family DY252_17250 ENOG4105EUB pirin domain protein DY252_17255 ENOG4105CS1 NAD(P)H quinone oxidoreductase DY252_17260 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase DY252_17275 ENOG4105T16 Transcriptional regulator (AraC family) DY252_17280 ENOG4108R86 Transcriptional regulator DY252_17290 ENOG4105F38 ABC transporter, permease DY252_17295 ENOG4105D38 putrescine abc transporter DY252_17300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_17320 ENOG4105EXU Membrane DY252_17335 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DY252_17350 ENOG41065G1 UPF0391 membrane protein DY252_17370 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DY252_17435 ENOG4105D00 flagellar biosynthetic protein flhB DY252_17440 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DY252_17445 ENOG4105VS8 Flagellar biosynthetic protein fliq DY252_17450 ENOG4105UVF flagellar hook-basal body complex protein fliE DY252_17455 ENOG4108ZC9 flagellar basal-body rod protein flgc DY252_17460 ENOG4105SFI flagellar basal-body rod protein DY252_17470 ENOG4105D00 flagellar biosynthetic protein flhB DY252_17485 ENOG4105CN7 Flagellar biosynthetic protein FliP DY252_17490 ENOG4105CJP fad dependent oxidoreductase DY252_17505 ENOG4106VK6 Flagellar motor protein DY252_17520 ENOG4108VYJ response regulator receiver protein DY252_17545 ENOG4108JQA flagellar DY252_17550 ENOG4105CGA flagellar basal-body rod protein FlgG DY252_17560 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DY252_17565 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters DY252_17570 ENOG4106909 Flagellar assembly regulator FliX DY252_17575 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DY252_17580 ENOG41065XG Chemotactic signal-response protein CheL DY252_17595 ENOG4105DTJ flagellar hook-associated protein DY252_17610 ENOG4105I03 Flagellin DY252_17615 ENOG4105I03 Flagellin DY252_17620 ENOG4105I03 Flagellin DY252_17640 ENOG4105MQ3 flagellar protein FliS DY252_17650 ENOG4105W00 Flagellar hook capping protein DY252_17655 ENOG4105BZE flagellar hook protein, FlgE DY252_17660 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DY252_17670 ENOG4105DD5 Flagellar motor switch protein DY252_17675 ENOG4105E14 MotA TolQ exbB proton channel DY252_17680 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_17685 ENOG4105D7B Flagellar biosynthesis protein flha DY252_17695 ENOG4107QMS site-determining protein DY252_17710 ENOG4107E2E PKHD-type hydroxylase DY252_17715 ENOG4108VGW abc transporter atp-binding protein DY252_17720 ENOG4105CXZ ABC transporter, permease DY252_17725 ENOG4105VNH ABC transporter solute-binding protein DY252_17730 ENOG4105EE5 Membrane protein terC DY252_17750 ENOG4108JIR Flagellum-specific ATP synthase DY252_17755 ENOG4105EFQ Two component transcriptional regulator (Winged helix family DY252_17765 ENOG4105BZU Histidine kinase DY252_17770 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DY252_17775 ENOG4107QQR Sporulation DY252_17785 ENOG4105CBS Chea signal transduction histidine kinase DY252_17830 ENOG4105FR1 rard protein DY252_17835 ENOG4105M2J Glutaredoxin DY252_17840 ENOG4105D8X mechanosensitive ion channel DY252_17850 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DY252_17865 ENOG4108IXY short-chain dehydrogenase reductase DY252_17870 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DY252_17890 ENOG4108ISG Major Facilitator DY252_17905 ENOG4105VUF Transcriptional regulator DY252_17910 ENOG4108Z8I decarboxylase DY252_17915 ENOG4105C8N cysteinyl-tRNA synthetase DY252_17920 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DY252_17925 ENOG4105C4K Nad synthetase DY252_17930 ENOG4105K8R UPF0145 protein DY252_17935 ENOG41083I7 UPF0145 protein DY252_17950 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase DY252_17965 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DY252_17970 ENOG4105DIQ Transcriptional regulator DY252_17975 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family DY252_17980 ENOG4108NDG TRAP dicarboxylate DY252_17990 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_18000 ENOG4105DC8 reductase DY252_18015 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DY252_18025 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) DY252_18035 ENOG4105D1U peptidase U62 modulator of DNA gyrase DY252_18055 ENOG4105C5W Aldolase DY252_18060 ENOG4105C5W Aldolase DY252_18065 ENOG4105DEF Extracellular solute-binding protein, family 5 DY252_18070 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY252_18075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY252_18080 ENOG4105C3U ABC transporter DY252_18085 ENOG4108JQ7 (ABC) transporter DY252_18090 ENOG4105N14 lysine exporter protein LysE YggA DY252_18110 ENOG4105C9Q fumarate hydratase class II DY252_18115 ENOG4105E98 transcriptional regulator DeoR family DY252_18130 ENOG4105S7S phosphonate abc transporter DY252_18140 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DY252_18155 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) DY252_18160 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DY252_18175 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DY252_18195 ENOG4105CMS peptidase U62, modulator of DNA gyrase DY252_18205 ENOG4105CBD Diacylglycerol kinase DY252_18215 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DY252_18225 ENOG4105BZ1 (ABC) transporter DY252_18240 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) DY252_18265 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DY252_18270 ENOG4105C12 Phosphoribosylglycinamide synthetase DY252_18275 ENOG4105E0A ABC, transporter DY252_18280 ENOG4105EHG Permease protein DY252_18295 ENOG4105CF7 AraC family transcriptional regulator DY252_18300 ENOG4105EMU Dehydrogenase DY252_18315 ENOG4108Z6B deaminase DY252_18320 ENOG4108Z86 Glutamine amidotransferase DY252_18330 ENOG4106H78 methyltransferase DY252_18355 ENOG4105FYV Amp nucleosidase DY252_18380 ENOG4108RMU ferritin dps family protein DY252_18390 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DY252_18395 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DY252_18400 ENOG4105BZU Histidine kinase DY252_18405 ENOG4105CAS nag kinase DY252_18410 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DY252_18415 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DY252_18420 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DY252_18425 ENOG41087PG RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DY252_18430 ENOG4107M91 50S ribosomal protein l34 DY252_18440 ENOG4107QZV Type I secretion membrane fusion protein DY252_18450 ENOG4108JJA ABC, transporter DY252_18455 ENOG4105VEJ Heat shock protein DY252_18465 ENOG4108Z4X TRANSCRIPTIONal DY252_18480 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DY252_18550 ENOG4105BZU Histidine kinase DY252_18555 ENOG4105CJW magnesium transporter DY252_18560 ENOG4105C6K Malic enzyme DY252_18570 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) DY252_18575 ENOG4105BZU Histidine kinase DY252_18620 ENOG4105BZU Histidine kinase DY252_18625 ENOG4105CI0 Citrate lyase DY252_18630 ENOG4108X0B nad(p)h dehydrogenase (quinone) DY252_18640 ENOG4105CIS alcohol dehydrogenase DY252_18645 ENOG4105KVH Transcriptional regulator DY252_18650 ENOG4105K5X acetyltransferase DY252_18655 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) DY252_18680 ENOG4105C26 Dehydrogenase DY252_18685 ENOG4105C8Y Acetylornithine aminotransferase DY252_18695 ENOG4108KJ1 Trap dicarboxylate transporter, dctp subunit DY252_18705 ENOG4108K1J Transporter DctQ DY252_18710 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_18730 ENOG4105ENR peptidase, M24 DY252_18735 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase DY252_18740 ENOG4108RYR transcriptional regulator AsnC family DY252_18770 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DY252_18775 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_18785 ENOG4105CH5 extracellular solute-binding protein, family 7 DY252_18810 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DY252_18815 ENOG4105CNN ABC, transporter DY252_18820 ENOG4105C2J ABC transporter DY252_18825 ENOG4105ETE Transcriptional regulator (LacI family DY252_18835 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) DY252_18850 ENOG4105FKQ transcriptional regulator DY252_18865 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DY252_18875 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_18910 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DY252_18915 ENOG4105ETX regulatoR DY252_18920 ENOG4105GR3 Histidine kinase DY252_18930 ENOG4108IV0 ABC, transporter DY252_18950 ENOG4107XBN GntR Family Transcriptional Regulator DY252_18955 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DY252_18960 ENOG4108RXX maleylacetoacetate isomerase DY252_18970 ENOG4105F1J Homogentisate 1,2-dioxygenase DY252_18985 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DY252_18995 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_19005 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DY252_19010 ENOG4105F7P transcriptional regulator AsnC family DY252_19015 ENOG4108IV0 ABC, transporter DY252_19020 ENOG4105C0Z ABC transporter DY252_19030 ENOG4105C32 Amino acid ABC transporter (Permease) DY252_19060 ENOG4105C26 Dehydrogenase DY252_19075 ENOG4105ERH Fumarylacetoacetate hydrolase DY252_19090 ENOG4105CZE histidine utilization repressor DY252_19095 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DY252_19100 ENOG4105CI2 imidazolone-5-propionate hydrolase DY252_19105 ENOG4105C84 Histidine ammonia-lyase DY252_19120 ENOG4105CH5 extracellular solute-binding protein, family 7 DY252_19130 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_19140 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_19160 ENOG4105CHU acetyl-coa acetyltransferase DY252_19175 ENOG4105E9F Enoyl-CoA hydratase DY252_19180 ENOG4108ERU trap dicarboxylate transporter subunit DctP DY252_19240 ENOG4105F2I Transposase DY252_19245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_19275 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_19290 ENOG4105CSU acyl-Coa dehydrogenase DY252_19295 ENOG4105CMG Carbohydrate kinase DY252_19300 ENOG41061GT Aldolase DY252_19310 ENOG4108FN7 Aldo keto reductase DY252_19315 ENOG4105DKT Transcriptional regulator DY252_19320 ENOG4105CNN ABC, transporter DY252_19335 ENOG4105BZU Histidine kinase DY252_19340 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY252_19355 ENOG4105C32 Amino acid ABC transporter (Permease) DY252_19365 ENOG4105C2J ABC transporter DY252_19370 ENOG4108IV0 ABC, transporter DY252_19375 ENOG4105C0A alcohol dehydrogenase DY252_19380 ENOG4105C26 Dehydrogenase DY252_19385 ENOG4105C0A alcohol dehydrogenase DY252_19390 ENOG4105CPC Aldo Keto reductase DY252_19400 ENOG4105CMT Dihydroxyacetone kinase DY252_19405 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DY252_19410 ENOG4105C2J ABC transporter DY252_19420 ENOG4105CNN ABC, transporter DY252_19425 ENOG4105ETE Transcriptional regulator (LacI family DY252_19435 ENOG4108UM1 dedA family DY252_19440 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) DY252_19445 ENOG41063TF transcriptional regulator (AraC DY252_19460 ENOG4105KDC 50s ribosomal protein l28 DY252_19470 ENOG4105BZU Histidine kinase DY252_19475 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) DY252_19495 ENOG4105M85 Bola protein DY252_19500 ENOG4105DKB L-sorbosone dehydrogenase DY252_19525 ENOG4108JU6 CBS domain protein DY252_19530 ENOG4105D49 3-dehydroquinate synthase DY252_19535 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DY252_19545 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DY252_19550 ENOG4105BZU Histidine kinase DY252_19565 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DY252_19585 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DY252_19605 ENOG4105JQN Transcriptional regulator DY252_19610 ENOG4105CHF Glutathione S-transferase DY252_19615 ENOG4108505 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DY252_19620 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DY252_19625 ENOG4107Q7J ATP synthase subunit C DY252_19630 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) DY252_19635 ENOG4107PQ6 Inherit from NOG: atp synthase DY252_19645 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DY252_19650 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DY252_19660 ENOG4105CEN a g-specific adenine glycosylase DY252_19670 ENOG4105CEC DNA methylase N-4 N-6 DY252_19685 ENOG4108JQ9 ABC transporter DY252_19690 ENOG41083U2 ABC transporter, permease DY252_19700 ENOG4105DZC cytosine deaminase DY252_19705 ENOG4107XWI flavin reductase domain protein, FMN-binding DY252_19715 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) DY252_19725 ENOG4108IYU L-aspartate oxidase DY252_19740 ENOG4105RK9 auxin efflux carrier DY252_19745 ENOG4108JJ7 ABC transporter DY252_19750 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) DY252_19755 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DY252_19765 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DY252_19770 ENOG4105C8Q Methyl-accepting chemotaxis DY252_19775 ENOG4105C8Q Methyl-accepting chemotaxis DY252_19780 ENOG4105E98 transcriptional regulator DeoR family DY252_19785 ENOG4105C8Y Acetylornithine aminotransferase DY252_19795 ENOG4105CHR reductase DY252_19800 ENOG4105NAE bifunctional deaminase-reductase domain protein DY252_19805 ENOG4105EJQ L-serine dehydratase DY252_19810 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DY252_19815 ENOG41063SB peptidase DY252_19820 ENOG4105CN1 protease DY252_19830 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DY252_19840 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) DY252_19865 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DY252_19875 ENOG4108VHC Short-chain dehydrogenase reductase Sdr DY252_19905 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) DY252_19930 ENOG4105DS0 Transcriptional regulator, Crp Fnr family DY252_19935 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DY252_19940 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DY252_19945 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY DY252_19950 ENOG4105K5M 30s ribosomal protein S16 DY252_19955 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DY252_19960 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DY252_19965 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DY252_19970 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DY252_19980 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DY252_19985 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DY252_19990 ENOG4108KPJ rna polymerase sigma factor DY252_19995 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DY252_20005 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DY252_20010 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DY252_20035 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY252_20040 ENOG4105CHR reductase DY252_20060 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DY252_20065 ENOG410856B UPF0235 protein DY252_20075 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DY252_20080 ENOG4105ETE Transcriptional regulator (LacI family DY252_20095 ENOG4105BZS acriflavin resistance protein DY252_20100 ENOG4105ENT Efflux transporter rnd family, mfp subunit DY252_20105 ENOG4108NVR Methyl-accepting chemotaxis DY252_20120 ENOG4105CYW agmatinase DY252_20125 ENOG4105EVZ LysR family transcriptional regulator DY252_20140 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) DY252_20160 ENOG4105D6J arsenicaL-resistance protein DY252_20165 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DY252_20175 ENOG4105C9A Phoh family DY252_20180 ENOG41076HS cation diffusion facilitator family transporter DY252_20185 ENOG4105DA4 cytochrome c-type biogenesis protein DY252_20190 ENOG4106FI7 cytochrome c-type biogenesis protein DY252_20205 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DY252_20210 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DY252_20215 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DY252_20220 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DY252_20225 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DY252_20230 ENOG4108K3A Glutathione S-transferase DY252_20245 ENOG4105C25 Primosomal protein n' DY252_20250 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DY252_20260 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DY252_20275 ENOG4108U78 Glutathione S-transferase DY252_20285 ENOG4105CFQ glutamine synthetase DY252_20295 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DY252_20300 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DY252_20305 ENOG4108Z4K mutator MutT protein DY252_20310 ENOG4105CR4 methylisocitrate lyase DY252_20315 ENOG4105EGS Mechanosensitive ion channel DY252_20325 ENOG4105D6Z AFG1 family ATPase DY252_20330 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DY252_20335 ENOG4105CMV Succinyl-CoA synthetase subunit beta DY252_20345 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DY252_20355 ENOG4107QN2 dihydrolipoyl dehydrogenase DY252_20360 ENOG4108Z5K methylglyoxal synthase DY252_20395 ENOG4105CT4 transporter DY252_20400 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DY252_20415 ENOG4105K6V RNA polymerase DY252_20420 ENOG4108NIX Factor ChrR DY252_20425 ENOG4105D6S protein involved in catabolism of external DNA DY252_20430 ENOG4108R99 pseudouridine synthase DY252_20450 ENOG4106TD9 Diguanylate cyclase DY252_20455 ENOG4105BZU Histidine kinase DY252_20460 ENOG4105CBX hi0933 family DY252_20490 ENOG4107QP3 malate synthase g DY252_20495 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DY252_20500 ENOG4105BZU Histidine kinase DY252_20505 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha DY252_20510 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta DY252_20515 ENOG4108M0I Transcriptional regulator DY252_20520 ENOG4105EN6 Membrane DY252_20550 ENOG4105ENV phosphonate C-P lyase system protein PhnK DY252_20555 ENOG4105HRV phosphonate c-p lyase system protein phnl DY252_20560 ENOG4105FD8 phosphonate metabolism protein PhnM DY252_20565 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DY252_20570 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) DY252_20585 ENOG4105EHI Phosphonate ABC transporter, periplasmic DY252_20590 ENOG4105D5T phosphonate abc transporter DY252_20595 ENOG4105DG4 malate L-lactate dehydrogenase DY252_20605 ENOG4105C94 Transporter DY252_20625 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY252_20630 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY252_20650 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) DY252_20655 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme DY252_20670 ENOG4105ECQ AraC Family Transcriptional Regulator DY252_20675 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DY252_20680 ENOG4105DVW rieske (2Fe-2S) DY252_20685 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DY252_20690 ENOG4105ECQ AraC Family Transcriptional Regulator DY252_20695 ENOG4105BZJ Electron transfer flavoprotein DY252_20700 ENOG4105C10 Electron transfer flavoprotein DY252_20705 ENOG4105CIY formyltetrahydrofolate deformylase DY252_20715 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein DY252_20725 ENOG4105BZU Histidine kinase DY252_20830 ENOG4105C59 p-type ATPase DY252_20835 ENOG4105KTU Transcriptional regulator, arsr family DY252_20870 ENOG4105DXI Major Facilitator superfamily DY252_20875 ENOG4105VPX protein, conserved in bacteria DY252_20880 ENOG4105EHV domain protein DY252_20900 ENOG4105PGM cation diffusion facilitator family transporter DY252_20910 ENOG4105DND Transcriptional regulator DY252_21000 ENOG4105ENT Efflux transporter rnd family, mfp subunit DY252_21015 ENOG41061A5 transposase DY252_21050 ENOG4105E4C Lytic transglycosylase catalytic DY252_21075 ENOG4107SKI cobyrinic Acid a,c-diamide synthase DY252_21135 ENOG4105CPC Aldo Keto reductase DY252_21195 ENOG4105J7D transcriptional regulator DY252_21205 ENOG4105W5Q DNA repair protein (RadC DY252_21270 ENOG4108KU3 Integrase DY252_21290 ENOG4105C0D helicase DY252_21400 ENOG4105CAF HipA N-terminal domain protein DY252_21470 ENOG4107T6V glycerophosphoryl diester phosphodiesterase DY252_21475 ENOG4107QI1 Mate efflux family protein DY252_21495 ENOG4105KJF protein tyrosine phosphatase DY252_21500 ENOG4105FGM Fructosamine kinase DY252_21510 ENOG4105EUJ GTP cyclohydrolase i DY252_21515 ENOG4105NWN ApaG protein DY252_21535 ENOG4105CUX Signal transduction histidine kinase DY252_21540 ENOG4108R3E Dna-3-methyladenine glycosylase i DY252_21550 ENOG4108RZE Tetr family transcriptional regulator DY252_21555 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) DY252_21560 ENOG4105BZU Histidine kinase DY252_21565 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DY252_21575 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) DY252_21600 ENOG4105DKB L-sorbosone dehydrogenase DY252_21605 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) DY252_21615 ENOG4105C8Q Methyl-accepting chemotaxis DY252_21625 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) DY252_21635 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase DY252_21640 ENOG4105EYW Ion transport protein DY252_21645 ENOG4105CRQ synthase (Component I) DY252_21655 ENOG4105VDW Csbd family DY252_21670 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase DY252_21680 ENOG4105BZU Histidine kinase DY252_21690 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) DY252_21695 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DY252_21710 ENOG4108RXX maleylacetoacetate isomerase DY252_21730 ENOG4105E09 nadh pyrophosphatase DY252_21740 ENOG4107QMP dna polymerase iii subunits gamma and tau DY252_21745 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DY252_21750 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DY252_21755 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DY252_21760 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DY252_21765 ENOG4108PVQ transcriptional regulator DY252_21770 ENOG4105E2X shikimate dehydrogenase DY252_21775 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DY252_21785 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DY252_21790 ENOG4107RYR Transcriptional regulator, Crp Fnr family DY252_21795 ENOG4105F8J Adenylate Guanylate cyclase DY252_21825 ENOG4105I8F Histidine kinase DY252_21830 ENOG4105DCI Phosphohydrolase DY252_21850 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) DY252_21855 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DY252_21860 ENOG41080Z8 PHOSPHOCARRIER protein DY252_21865 ENOG4108EQA pts system DY252_21870 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DY252_21875 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DY252_21880 ENOG4105EB3 Histidine kinase DY252_21885 ENOG4105E3W Two component transcriptional regulator (Winged helix family DY252_21930 ENOG4105HEI LysR family (Transcriptional regulator DY252_21940 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DY252_21950 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DY252_21960 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DY252_21965 ENOG4105EJC lysr family transcriptional regulator DY252_21990 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DY252_21995 ENOG410642W LysR family Transcriptional regulator DY252_22005 ENOG4105CHR reductase DY252_22010 ENOG41083AI transcriptional regulator), MarR family DY252_22020 ENOG4105CHH sulfate transporter DY252_22045 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DY252_22050 ENOG4105DBV ornithine carbamoyltransferase DY252_22055 ENOG4105C8Y Acetylornithine aminotransferase DY252_22060 ENOG4105E3A (ABC) transporter DY252_22065 ENOG4105GB5 regulatory protein RecX DY252_22070 ENOG4105K89 arsenate reductase DY252_22085 ENOG41067MG lrgb family DY252_22105 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DY252_22110 ENOG4105CDH Citrulline--aspartate ligase DY252_22120 ENOG410829K Lysine exporter protein (Lyse ygga) DY252_22125 ENOG4105DDW LysR family Transcriptional regulator DY252_22130 ENOG4105JN3 extra-cytoplasmic solute receptor family protein DY252_22145 ENOG4105CWC Acetylornithine deacetylase DY252_22160 ENOG4108JQC penicillin-binding protein 1A DY252_22165 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase