locus-tag	class	description
DY252_00025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DY252_00040	COG1063	alcohol dehydrogenase
DY252_00055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_00060	COG1802	Transcriptional regulator
DY252_00065	COG1312	Catalyzes the dehydration of D-mannonate
DY252_00070	COG0246	Mannitol dehydrogenase
DY252_00075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_00080	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DY252_00125	COG2226	methyltransferase
DY252_00150	COG1846	Transcriptional regulator
DY252_00155	COG0438	transferase activity, transferring glycosyl groups
DY252_00160	COG0154	amidase activity
DY252_00165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DY252_00170	COG4172	Belongs to the ABC transporter superfamily
DY252_00175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DY252_00180	COG0601	transmembrane transport
DY252_00190	COG0235	Class ii aldolase
DY252_00205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DY252_00210	COG1070	Carbohydrate kinase
DY252_00215	COG3254	rhamnose metabolic process
DY252_00225	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_00230	COG1129	ABC transporter
DY252_00240	COG1349	DNA-binding transcription factor activity
DY252_00245	COG3347	Dehydrogenase
DY252_00245	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_00250	COG4952	isomerase
DY252_00295	COG0789	Transcriptional regulator
DY252_00305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DY252_00310	COG1999	signal sequence binding
DY252_00315	COG2847	Copper chaperone PCu(A)C
DY252_00325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DY252_00330	COG1999	signal sequence binding
DY252_00355	COG1321	iron dependent repressor
DY252_00380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DY252_00385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DY252_00400	COG1999	signal sequence binding
DY252_00415	COG0785	Cytochrome C biogenesis protein
DY252_00440	COG0789	Transcriptional regulator
DY252_00510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DY252_00555	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DY252_00570	COG4191	Histidine kinase
DY252_00575	COG1840	ABC-type Fe3 transport system, periplasmic component
DY252_00580	COG0187	DNA topoisomerase II activity
DY252_00585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DY252_00590	COG0592	DNA-directed DNA polymerase activity
DY252_00595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DY252_00600	COG0268	Binds directly to 16S ribosomal RNA
DY252_00605	COG1024	Enoyl-CoA hydratase
DY252_00610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DY252_00615	COG0730	response to heat
DY252_00620	COG2814	Major facilitator Superfamily
DY252_00635	COG0776	regulation of translation
DY252_00640	COG0616	signal peptide processing
DY252_00645	COG0539	negative regulation of cytoplasmic translation
DY252_00680	COG1309	transcriptional regulator
DY252_00685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DY252_00690	COG0235	Class ii aldolase
DY252_00710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DY252_00725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DY252_00725	COG0519	Catalyzes the synthesis of GMP from XMP
DY252_00745	COG1234	tRNA 3'-trailer cleavage
DY252_00760	COG2983	Belongs to the UPF0260 family
DY252_00770	COG1999	signal sequence binding
DY252_00785	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DY252_00795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DY252_00825	COG1492	cobalamin metabolic process
DY252_00865	COG0588	phosphoglycerate mutase activity
DY252_00870	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DY252_00875	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DY252_00885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DY252_00905	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DY252_00910	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DY252_00940	COG2308	Evidence 4 Homologs of previously reported genes of
DY252_00950	COG1305	Transglutaminase-like
DY252_00960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DY252_00995	COG2226	methyltransferase
DY252_01005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DY252_01010	COG1120	ATPase activity
DY252_01015	COG4303	Ethanolamine ammonia lyase large subunit
DY252_01020	COG4302	ethanolamine ammonia-lyase activity
DY252_01030	COG1592	Rubrerythrin
DY252_01045	COG1185	polyribonucleotide nucleotidyltransferase activity
DY252_01050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DY252_01055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DY252_01060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DY252_01070	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DY252_01090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DY252_01095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DY252_01100	COG1396	sequence-specific DNA binding
DY252_01105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DY252_01110	COG1253	flavin adenine dinucleotide binding
DY252_01120	COG1702	phosphate starvation-inducible protein PhoH
DY252_01125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DY252_01155	COG1214	PFAM Peptidase M22, glycoprotease
DY252_01160	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DY252_01165	COG3842	ATPase activity
DY252_01170	COG0395	ABC-type sugar transport system, permease component
DY252_01180	COG1653	transport
DY252_01185	COG2723	6-phospho-beta-galactosidase activity
DY252_01190	COG1609	Transcriptional regulator
DY252_01195	COG1285	pathogenesis
DY252_01205	COG1280	lysine exporter protein (LysE YggA)
DY252_01215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DY252_01225	COG1959	2 iron, 2 sulfur cluster binding
DY252_01230	COG0756	dUTP diphosphatase activity
DY252_01250	COG5002	protein histidine kinase activity
DY252_01255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DY252_01265	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DY252_01270	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DY252_01295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DY252_01330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DY252_01340	COG0583	DNA-binding transcription factor activity
DY252_01345	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_01370	COG0667	Aldo Keto reductase
DY252_01380	COG0583	DNA-binding transcription factor activity
DY252_01385	COG0606	chelatase, subunit chli
DY252_01405	COG1846	Transcriptional regulator
DY252_01425	COG0625	glutathione transferase activity
DY252_01495	COG3030	protein affecting phage T7 exclusion by the F plasmid
DY252_01500	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DY252_01510	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DY252_01520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DY252_01540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DY252_01560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DY252_01575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DY252_01600	COG1331	Highly conserved protein containing a thioredoxin domain
DY252_01610	COG3411	Ferredoxin
DY252_01615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DY252_01620	COG0445	tRNA wobble uridine modification
DY252_01630	COG1192	Involved in chromosome partitioning
DY252_01635	COG1475	DNA binding
DY252_01675	COG0352	thiamine-phosphate diphosphorylase activity
DY252_01685	COG0745	RESPONSE REGULATOR receiver
DY252_01710	COG0180	Tryptophanyl-tRNA synthetase
DY252_01725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DY252_01740	COG0280	phosphate acetyltransferase
DY252_01740	COG0281	malic enzyme
DY252_01755	COG2992	FlgJ-related protein
DY252_01760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DY252_01775	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DY252_01780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DY252_01785	COG1216	Glycosyl transferase, family 2
DY252_01825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DY252_01830	COG1420	regulation of RNA biosynthetic process
DY252_01835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DY252_01840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DY252_01845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DY252_01865	COG1696	Membrane protein involved in D-alanine export
DY252_01895	COG1137	ATPase activity
DY252_01900	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DY252_01905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DY252_01910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DY252_01915	COG2211	Major facilitator Superfamily
DY252_01925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_01955	COG0792	nuclease activity
DY252_01960	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DY252_01970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DY252_01990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DY252_01995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DY252_01995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DY252_02015	COG0285	dihydrofolate synthase activity
DY252_02020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DY252_02030	COG0133	tryptophan synthase activity
DY252_02040	COG1131	(ABC) transporter
DY252_02050	COG2267	carboxylic ester hydrolase activity
DY252_02070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DY252_02075	COG0028	Belongs to the TPP enzyme family
DY252_02090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DY252_02100	COG5001	Diguanylate cyclase
DY252_02100	COG4251	negative regulation of phosphorylation
DY252_02100	COG3706	GGDEF domain
DY252_02100	COG2203	Gaf domain
DY252_02110	COG0745	RESPONSE REGULATOR receiver
DY252_02110	COG2205	protein histidine kinase activity
DY252_02110	COG4191	Histidine kinase
DY252_02120	COG4566	intracellular signal transduction
DY252_02130	COG1741	Belongs to the pirin family
DY252_02135	COG0583	DNA-binding transcription factor activity
DY252_02160	COG3842	ATPase activity
DY252_02170	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_02175	COG4208	sulfate ABC transporter
DY252_02185	COG2186	Transcriptional regulator
DY252_02190	COG0730	response to heat
DY252_02245	COG1024	Enoyl-CoA hydratase
DY252_02255	COG1960	acyl-CoA dehydrogenase activity
DY252_02260	COG1024	Enoyl-CoA hydratase
DY252_02260	COG1250	3-hydroxyacyl-CoA dehydrogenase
DY252_02275	COG0318	PFAM AMP-dependent synthetase and ligase
DY252_02295	COG4520	surface antigen
DY252_02300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DY252_02310	COG2807	transmembrane transport
DY252_02320	COG4771	TonB-dependent receptor
DY252_02325	COG3720	iron ion transport
DY252_02330	COG4558	Periplasmic binding protein
DY252_02335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DY252_02340	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DY252_02345	COG0583	DNA-binding transcription factor activity
DY252_02360	COG1012	belongs to the aldehyde dehydrogenase family
DY252_02365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DY252_02375	COG0352	thiamine-phosphate diphosphorylase activity
DY252_02385	COG2183	response to ionizing radiation
DY252_02395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DY252_02400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DY252_02400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DY252_02405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DY252_02415	COG5383	Protein conserved in bacteria
DY252_02420	COG0138	bifunctional purine biosynthesis protein purh
DY252_02440	COG0181	hydroxymethylbilane synthase activity
DY252_02450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DY252_02455	COG2350	Protein conserved in bacteria
DY252_02475	COG0438	transferase activity, transferring glycosyl groups
DY252_02485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DY252_02490	COG0745	RESPONSE REGULATOR receiver
DY252_02495	COG0679	Auxin Efflux Carrier
DY252_02505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DY252_02510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DY252_02515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DY252_02520	COG0072	phenylalanine-tRNA ligase activity
DY252_02530	COG4251	negative regulation of phosphorylation
DY252_02545	COG4702	Belongs to the UPF0303 family
DY252_02560	COG0802	atpase or kinase
DY252_02570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DY252_02580	COG1074	ATP-dependent DNA helicase activity
DY252_02590	COG0840	transmembrane signaling receptor activity
DY252_02605	COG0004	ammonium transporteR
DY252_02610	COG0004	ammonium transporteR
DY252_02620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DY252_02625	COG3047	cAMP biosynthetic process
DY252_02635	COG2835	tetraacyldisaccharide 4'-kinase activity
DY252_02645	COG3118	belongs to the thioredoxin family
DY252_02670	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DY252_02675	COG2902	Dehydrogenase
DY252_02680	COG1309	transcriptional regulator
DY252_02685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DY252_02705	COG0501	Belongs to the peptidase M48B family
DY252_02715	COG0670	Belongs to the BI1 family
DY252_02725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DY252_02730	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DY252_02735	COG4181	ATPase activity
DY252_02755	COG0667	Aldo Keto reductase
DY252_02760	COG1741	Belongs to the pirin family
DY252_02770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DY252_02780	COG0697	spore germination
DY252_02785	COG1846	Transcriptional regulator
DY252_02860	COG4166	transmembrane transport
DY252_02865	COG4174	ABC transporter (Permease)
DY252_02870	COG4239	(ABC) transporter, permease
DY252_02875	COG4172	Belongs to the ABC transporter superfamily
DY252_02895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DY252_02905	COG1573	uracil-dna glycosylase
DY252_02910	COG2154	pterin-4-alpha-carbinolamine dehydratase
DY252_02920	COG0697	spore germination
DY252_02925	COG0697	spore germination
DY252_02930	COG0697	spore germination
DY252_02935	COG1522	sequence-specific DNA binding
DY252_02940	COG3263	regulation of cellular component size
DY252_02955	COG1280	lysine exporter protein (LysE YggA)
DY252_02975	COG3474	cytochrome
DY252_02980	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DY252_02990	COG0840	transmembrane signaling receptor activity
DY252_02995	COG0513	Belongs to the DEAD box helicase family
DY252_03010	COG1960	acyl-CoA dehydrogenase activity
DY252_03015	COG0183	Belongs to the thiolase family
DY252_03030	COG0288	reversible hydration of carbon dioxide
DY252_03035	COG1960	acyl-CoA dehydrogenase activity
DY252_03040	COG3550	peptidyl-serine autophosphorylation
DY252_03050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DY252_03055	COG1842	Phage shock protein A
DY252_03090	COG2301	Belongs to the HpcH HpaI aldolase family
DY252_03095	COG2030	dehydratase
DY252_03115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DY252_03125	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DY252_03130	COG4266	Belongs to the allantoicase family
DY252_03155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DY252_03155	COG2010	Cytochrome c
DY252_03165	COG0590	tRNA wobble adenosine to inosine editing
DY252_03170	COG1129	ABC transporter
DY252_03200	COG0840	transmembrane signaling receptor activity
DY252_03210	COG0583	DNA-binding transcription factor activity
DY252_03220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DY252_03235	COG0559	Belongs to the binding-protein-dependent transport system permease family
DY252_03245	COG0411	ABC transporter
DY252_03250	COG0410	ABC transporter
DY252_03255	COG0829	nickel cation binding
DY252_03260	COG0831	urea catabolic process
DY252_03265	COG0832	Belongs to the urease beta subunit family
DY252_03270	COG0804	urea catabolic process
DY252_03275	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DY252_03280	COG0830	nickel cation binding
DY252_03285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DY252_03295	COG0640	Transcriptional regulator
DY252_03300	COG1268	BioY protein
DY252_03305	COG1122	ATPase activity
DY252_03310	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DY252_03320	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DY252_03325	COG0583	DNA-binding transcription factor activity
DY252_03335	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_03375	COG2095	MarC family integral membrane protein
DY252_03385	COG0501	Belongs to the peptidase M48B family
DY252_03395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DY252_03670	COG1703	isobutyryl-CoA mutase activity
DY252_03690	COG3186	Phenylalanine-4-hydroxylase
DY252_03695	COG1522	sequence-specific DNA binding
DY252_03710	COG2205	protein histidine kinase activity
DY252_03710	COG4191	Histidine kinase
DY252_03710	COG0745	RESPONSE REGULATOR receiver
DY252_03715	COG2204	response regulator
DY252_03720	COG2207	Transcriptional regulator
DY252_03720	COG4753	response regulator
DY252_03740	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DY252_03745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DY252_03795	COG1058	Belongs to the CinA family
DY252_03795	COG1546	Belongs to the CinA family
DY252_03810	COG0778	Nitroreductase
DY252_03845	COG1968	undecaprenyl-diphosphatase activity
DY252_03875	COG0747	negative chemotaxis
DY252_03890	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DY252_03900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_03915	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DY252_03920	COG0277	FAD linked oxidase domain protein
DY252_03925	COG0277	FAD linked oxidase domain protein
DY252_03930	COG0247	lactate metabolic process
DY252_03940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DY252_03945	COG0573	inorganic phosphate transmembrane transporter activity
DY252_03950	COG0581	inorganic phosphate transmembrane transporter activity
DY252_03960	COG0704	Plays a role in the regulation of phosphate uptake
DY252_03965	COG0745	RESPONSE REGULATOR receiver
DY252_03980	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_03995	COG2233	PERMEase
DY252_04000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DY252_04005	COG0314	molybdopterin synthase activity
DY252_04020	COG2813	Specifically methylates the guanine in position
DY252_04020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DY252_04025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DY252_04040	COG0287	Prephenate dehydrogenase
DY252_04045	COG0697	spore germination
DY252_04060	COG0204	Acyl-transferase
DY252_04075	COG2884	Cell division ATP-binding protein ftsE
DY252_04090	COG1595	DNA-templated transcription, initiation
DY252_04095	COG3712	iron ion homeostasis
DY252_04110	COG0019	diaminopimelate decarboxylase activity
DY252_04115	COG0165	Argininosuccinate lyase
DY252_04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DY252_04125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_04130	COG1070	Carbohydrate kinase
DY252_04135	COG1250	3-hydroxyacyl-CoA dehydrogenase
DY252_04150	COG2096	Adenosyltransferase
DY252_04160	COG3604	Transcriptional regulator
DY252_04165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DY252_04170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_04175	COG1116	anion transmembrane transporter activity
DY252_04180	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
DY252_04185	COG0625	glutathione transferase activity
DY252_04220	COG1309	transcriptional regulator
DY252_04225	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_04235	COG0328	RNA-DNA hybrid ribonuclease activity
DY252_04240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DY252_04245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DY252_04255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DY252_04260	COG0509	glycine decarboxylation via glycine cleavage system
DY252_04265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DY252_04270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DY252_04285	COG0678	peroxiredoxin activity
DY252_04285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DY252_04295	COG1678	Uncharacterized ACR, COG1678
DY252_04305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DY252_04315	COG0109	protoheme IX farnesyltransferase activity
DY252_04320	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DY252_04340	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DY252_04345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_04355	COG0612	Peptidase, M16
DY252_04390	COG1473	amidohydrolase
DY252_04405	COG0583	DNA-binding transcription factor activity
DY252_04420	COG1012	belongs to the aldehyde dehydrogenase family
DY252_04430	COG1573	uracil-dna glycosylase
DY252_04435	COG0741	lytic transglycosylase activity
DY252_04450	COG3088	subunit of a heme lyase
DY252_04455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DY252_04460	COG1138	Cytochrome C-type biogenesis protein
DY252_04465	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DY252_04475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DY252_04480	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DY252_04495	COG0733	neurotransmitter:sodium symporter activity
DY252_04500	COG3300	MHYT domain
DY252_04500	COG5001	Diguanylate cyclase
DY252_04525	COG0559	Belongs to the binding-protein-dependent transport system permease family
DY252_04540	COG0410	ABC transporter
DY252_04550	COG0701	Predicted permease
DY252_04560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DY252_04560	COG2111	Na H antiporter
DY252_04565	COG1006	Multisubunit Na H antiporter MnhC subunit
DY252_04570	COG0651	ATP synthesis coupled electron transport
DY252_04575	COG1863	multisubunit Na H antiporter MnhE subunit
DY252_04580	COG2212	antiporter activity
DY252_04585	COG1320	monovalent cation:proton antiporter activity
DY252_04590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DY252_04605	COG2832	Protein of unknown function (DUF454)
DY252_04615	COG4251	negative regulation of phosphorylation
DY252_04650	COG4783	chaperone-mediated protein folding
DY252_04675	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DY252_04690	COG0583	DNA-binding transcription factor activity
DY252_04695	COG1960	acyl-CoA dehydrogenase activity
DY252_04700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DY252_04705	COG3842	ATPase activity
DY252_04710	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_04715	COG1177	transmembrane transport
DY252_04720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DY252_04730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DY252_04740	COG2207	Transcriptional regulator
DY252_04760	COG2207	Transcriptional regulator
DY252_04805	COG3300	MHYT domain
DY252_04805	COG5001	Diguanylate cyclase
DY252_04810	COG4942	peptidase
DY252_04820	COG2226	methyltransferase
DY252_04825	COG2030	dehydratase
DY252_04830	COG0196	riboflavin kinase activity
DY252_04840	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DY252_04850	COG0612	Peptidase, M16
DY252_04855	COG0612	Peptidase, M16
DY252_04860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DY252_04875	COG1360	Flagellar Motor Protein
DY252_04880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DY252_04890	COG2375	cellular response to nickel ion
DY252_04895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DY252_04900	COG1321	iron dependent repressor
DY252_04900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DY252_04905	COG1121	(ABC) transporter
DY252_04910	COG0803	Belongs to the bacterial solute-binding protein 9 family
DY252_04915	COG1321	iron dependent repressor
DY252_04935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DY252_04935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DY252_04945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DY252_04965	COG0367	asparagine synthase
DY252_04970	COG0438	transferase activity, transferring glycosyl groups
DY252_04995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DY252_05005	COG1086	Polysaccharide biosynthesis protein
DY252_05010	COG2089	acid synthase
DY252_05015	COG1132	(ABC) transporter
DY252_05030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DY252_05035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DY252_05040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DY252_05050	COG1396	sequence-specific DNA binding
DY252_05070	COG3243	poly(R)-hydroxyalkanoic acid synthase
DY252_05080	COG1522	sequence-specific DNA binding
DY252_05095	COG2132	Multicopper oxidase
DY252_05125	COG1072	(Pantothenic acid kinase))
DY252_05150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DY252_05180	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DY252_05210	COG0583	DNA-binding transcription factor activity
DY252_05215	COG3119	arylsulfatase activity
DY252_05225	COG0693	protein deglycase activity
DY252_05235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DY252_05240	COG1846	Transcriptional regulator
DY252_05245	COG0745	RESPONSE REGULATOR receiver
DY252_05275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DY252_05305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DY252_05330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DY252_05335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DY252_05345	COG0012	GTP binding
DY252_05350	COG0519	Catalyzes the synthesis of GMP from XMP
DY252_05350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DY252_05355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DY252_05355	COG1618	nucleotide phosphatase activity, acting on free nucleotides
DY252_05360	COG1063	alcohol dehydrogenase
DY252_05370	COG0583	DNA-binding transcription factor activity
DY252_05375	COG0450	alkyl hydroperoxide reductase
DY252_05380	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DY252_05405	COG2205	protein histidine kinase activity
DY252_05425	COG0556	nucleotide-excision repair
DY252_05430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DY252_05435	COG0583	DNA-binding transcription factor activity
DY252_05440	COG4336	lyase activity
DY252_05455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_05465	COG0154	amidase activity
DY252_05485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_05490	COG0783	Belongs to the Dps family
DY252_05495	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DY252_05500	COG0583	DNA-binding transcription factor activity
DY252_05505	COG0492	ferredoxin-NADP+ reductase activity
DY252_05510	COG1522	sequence-specific DNA binding
DY252_05515	COG4783	chaperone-mediated protein folding
DY252_05530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DY252_05540	COG0505	Belongs to the CarA family
DY252_05545	COG1610	YqeY-like protein
DY252_05550	COG0358	DNA primase activity
DY252_05555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DY252_05635	COG3561	AntA/AntB antirepressor
DY252_05775	COG4695	Portal protein
DY252_05815	COG4544	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
DY252_05820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DY252_05830	COG1070	Carbohydrate kinase
DY252_05835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DY252_05840	COG3842	ATPase activity
DY252_05845	COG1063	alcohol dehydrogenase
DY252_05860	COG1175	transmembrane transport
DY252_05870	COG2390	Transcriptional regulator
DY252_05875	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_05885	COG1618	nucleotide phosphatase activity, acting on free nucleotides
DY252_05885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DY252_05890	COG0288	reversible hydration of carbon dioxide
DY252_05895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DY252_05900	COG2181	nitrate reductase activity
DY252_05905	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DY252_05910	COG1140	nitrate reductase beta subunit
DY252_05915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DY252_05920	COG2223	nitrite transmembrane transporter activity
DY252_05930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DY252_05960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_06005	COG1609	Transcriptional regulator
DY252_06025	COG1879	ABC-type sugar transport system periplasmic component
DY252_06030	COG1129	ABC transporter
DY252_06035	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_06040	COG1129	ABC transporter
DY252_06045	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_06085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_06110	COG0673	inositol 2-dehydrogenase activity
DY252_06120	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_06125	COG1129	ABC transporter
DY252_06130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_06135	COG3962	Belongs to the TPP enzyme family
DY252_06145	COG3718	enzyme involved in inositol metabolism
DY252_06150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DY252_06150	COG1648	precorrin-2 dehydrogenase activity
DY252_06155	COG0243	molybdopterin cofactor binding
DY252_06160	COG2146	nitrite reductase [NAD(P)H] activity
DY252_06165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DY252_06175	COG2223	nitrite transmembrane transporter activity
DY252_06185	COG1116	anion transmembrane transporter activity
DY252_06185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DY252_06195	COG0446	pyridine nucleotide-disulphide oxidoreductase
DY252_06195	COG1902	pentaerythritol trinitrate reductase activity
DY252_06200	COG0583	DNA-binding transcription factor activity
DY252_06205	COG4638	Rieske (2fe-2S)
DY252_06215	COG3335	DDE superfamily endonuclease
DY252_06220	COG2207	Transcriptional regulator
DY252_06235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DY252_06235	COG0446	pyridine nucleotide-disulphide oxidoreductase
DY252_06245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DY252_06255	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DY252_06260	COG4149	molybdate abc transporter
DY252_06265	COG0725	ABC transporter, periplasmic molybdate-binding protein
DY252_06275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DY252_06280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DY252_06280	COG0517	IMP dehydrogenase activity
DY252_06285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DY252_06295	COG0488	(ABC) transporter
DY252_06305	COG2853	Lipoprotein
DY252_06310	COG2226	methyltransferase
DY252_06325	COG0646	methionine synthase
DY252_06325	COG1410	methionine synthase
DY252_06330	COG2814	Major facilitator Superfamily
DY252_06335	COG0038	chloride channel
DY252_06345	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DY252_06350	COG0210	DNA helicase
DY252_06355	COG2264	protein methyltransferase activity
DY252_06375	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_06385	COG0006	proline dipeptidase activity
DY252_06390	COG0667	Aldo Keto reductase
DY252_06400	COG0697	spore germination
DY252_06425	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DY252_06435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DY252_06440	COG0849	cell division
DY252_06445	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DY252_06450	COG1181	Belongs to the D-alanine--D-alanine ligase family
DY252_06455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DY252_06460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DY252_06475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DY252_06490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DY252_06495	COG0768	penicillin binding
DY252_06525	COG0598	Magnesium transport protein CorA
DY252_06530	COG1335	isochorismatase
DY252_06545	COG3023	N-Acetylmuramoyl-L-alanine amidase
DY252_06560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DY252_06570	COG0840	transmembrane signaling receptor activity
DY252_06580	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_06605	COG0069	glutamate synthase activity
DY252_06610	COG3811	Belongs to the UPF0386 family
DY252_06615	COG0456	acetyltransferase
DY252_06615	COG0454	-acetyltransferase
DY252_06630	COG0277	FAD linked oxidase domain protein
DY252_06650	COG2982	Protein involved in outer membrane biogenesis
DY252_06655	COG0306	phosphate transporter
DY252_06660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DY252_06665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DY252_06670	COG0343	queuine tRNA-ribosyltransferase activity
DY252_06675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DY252_06680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DY252_06685	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DY252_06700	COG0784	Response regulator, receiver
DY252_06700	COG2205	protein histidine kinase activity
DY252_06700	COG5002	protein histidine kinase activity
DY252_06710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DY252_06715	COG3246	L-lysine catabolic process to acetate
DY252_06730	COG0589	response to stress
DY252_06740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DY252_06750	COG3474	cytochrome
DY252_06770	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_06785	COG0142	geranyltranstransferase activity
DY252_06795	COG2890	protein-(glutamine-N5) methyltransferase activity
DY252_06805	COG0752	glycyl-tRNA synthetase alpha subunit
DY252_06815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DY252_06815	COG0574	Belongs to the PEP-utilizing enzyme family
DY252_06825	COG0354	folic acid binding
DY252_06840	COG0367	asparagine synthase
DY252_06850	COG3339	Conserved Protein
DY252_06855	COG0604	alcohol dehydrogenase
DY252_06905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DY252_06915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DY252_06935	COG1530	ribonuclease E activity
DY252_06940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DY252_06965	COG0415	Belongs to the DNA photolyase family
DY252_06980	COG2313	pseudouridylate synthase activity
DY252_06985	COG2814	Major facilitator Superfamily
DY252_06990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DY252_06995	COG0440	acetolactate synthase activity
DY252_07000	COG0028	Belongs to the TPP enzyme family
DY252_07010	COG0560	Phosphoserine phosphatase
DY252_07010	COG3830	Belongs to the UPF0237 family
DY252_07030	COG0330	HflC and HflK could
DY252_07035	COG0489	protein tyrosine kinase activity
DY252_07045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DY252_07050	COG0047	phosphoribosylformylglycinamidine synthase activity
DY252_07055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DY252_07060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DY252_07075	COG2197	response regulator
DY252_07080	COG0504	CTP synthase activity
DY252_07085	COG0697	spore germination
DY252_07090	COG0583	DNA-binding transcription factor activity
DY252_07095	COG1881	PFAM PEBP family protein
DY252_07100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DY252_07105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DY252_07115	COG0444	Belongs to the ABC transporter superfamily
DY252_07120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DY252_07125	COG0601	transmembrane transport
DY252_07130	COG4166	transmembrane transport
DY252_07145	COG0346	lactoylglutathione lyase activity
DY252_07150	COG2003	Belongs to the UPF0758 family
DY252_07155	COG0024	Methionine aminopeptidase
DY252_07160	COG1489	DNA binding
DY252_07175	COG1017	nitric oxide dioxygenase activity
DY252_07175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DY252_07180	COG0625	glutathione transferase activity
DY252_07185	COG0583	DNA-binding transcription factor activity
DY252_07190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DY252_07210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DY252_07240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DY252_07265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DY252_07275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DY252_07280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DY252_07285	COG2890	protein-(glutamine-N5) methyltransferase activity
DY252_07305	COG0542	response to heat
DY252_07320	COG1022	Amp-dependent synthetase and ligase
DY252_07330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DY252_07335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DY252_07340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DY252_07345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DY252_07365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DY252_07380	COG0242	peptide deformylase activity
DY252_07395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DY252_07400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DY252_07445	COG0583	DNA-binding transcription factor activity
DY252_07450	COG1349	DNA-binding transcription factor activity
DY252_07460	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_07460	COG0604	alcohol dehydrogenase
DY252_07460	COG3321	synthase
DY252_07480	COG0254	rRNA binding
DY252_07490	COG1132	(ABC) transporter
DY252_07495	COG0739	heme binding
DY252_07535	COG1959	2 iron, 2 sulfur cluster binding
DY252_07540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DY252_07550	COG4208	sulfate ABC transporter
DY252_07555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DY252_07560	COG0471	metal ion transport
DY252_07560	COG3273	potassium ion transport
DY252_07585	COG1116	anion transmembrane transporter activity
DY252_07590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_07595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DY252_07600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DY252_07610	COG3273	potassium ion transport
DY252_07610	COG0471	metal ion transport
DY252_07620	COG2059	Chromate
DY252_07635	COG4227	nucleotidyltransferase activity
DY252_07645	COG1475	DNA binding
DY252_07675	COG0681	Belongs to the peptidase S26 family
DY252_07680	COG0741	lytic transglycosylase activity
DY252_07710	COG4962	Type ii secretion system protein e
DY252_07725	COG3451	type IV secretory pathway VirB4
DY252_07750	COG2948	multi-organism process
DY252_07840	COG3483	tryptophan 2,3-dioxygenase activity
DY252_07860	COG1129	ABC transporter
DY252_07880	COG1177	transmembrane transport
DY252_07885	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_07900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DY252_07915	COG4221	oxidoreductase activity
DY252_07920	COG2204	response regulator
DY252_07925	COG4191	Histidine kinase
DY252_07940	COG0583	DNA-binding transcription factor activity
DY252_07955	COG3383	formate dehydrogenase (NAD+) activity
DY252_07965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DY252_07970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DY252_07985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DY252_07995	COG1846	Transcriptional regulator
DY252_07995	COG1940	carbohydrate kinase activity
DY252_08010	COG4214	carbohydrate transport
DY252_08015	COG4213	ABC transporter substrate-binding protein
DY252_08020	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_08025	COG0129	dihydroxy-acid dehydratase activity
DY252_08040	COG0069	glutamate synthase activity
DY252_08045	COG2218	PFAM glutamate synthase alpha subunit domain protein
DY252_08050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DY252_08060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DY252_08085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DY252_08095	COG4977	sequence-specific DNA binding
DY252_08100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_08105	COG4311	Sarcosine oxidase, delta subunit
DY252_08110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DY252_08110	COG0446	pyridine nucleotide-disulphide oxidoreductase
DY252_08145	COG2391	methyltransferase activity
DY252_08155	COG0513	Belongs to the DEAD box helicase family
DY252_08160	COG1278	Cold shock
DY252_08165	COG2186	Transcriptional regulator
DY252_08175	COG0765	amino acid transport
DY252_08195	COG1671	Belongs to the UPF0178 family
DY252_08215	COG0523	cobalamin synthesis protein
DY252_08220	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DY252_08230	COG0840	transmembrane signaling receptor activity
DY252_08235	COG0625	glutathione transferase activity
DY252_08240	COG0625	glutathione transferase activity
DY252_08245	COG0477	Major facilitator Superfamily
DY252_08250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DY252_08255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DY252_08260	COG1845	cytochrome c oxidase, subunit III
DY252_08265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DY252_08280	COG0625	glutathione transferase activity
DY252_08290	COG2226	methyltransferase
DY252_08295	COG1309	transcriptional regulator
DY252_08305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DY252_08325	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DY252_08325	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DY252_08335	COG0697	spore germination
DY252_08345	COG3180	Ammonia monooxygenase
DY252_08370	COG5001	Diguanylate cyclase
DY252_08380	COG0745	RESPONSE REGULATOR receiver
DY252_08380	COG3706	GGDEF domain
DY252_08385	COG1366	Belongs to the anti-sigma-factor antagonist family
DY252_08390	COG2204	response regulator
DY252_08415	COG1879	ABC-type sugar transport system periplasmic component
DY252_08420	COG3706	GGDEF domain
DY252_08420	COG0745	RESPONSE REGULATOR receiver
DY252_08425	COG0772	Belongs to the SEDS family
DY252_08430	COG0768	penicillin binding
DY252_08455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DY252_08465	COG1280	lysine exporter protein (LysE YggA)
DY252_08480	COG3706	GGDEF domain
DY252_08490	COG1278	Cold shock
DY252_08495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DY252_08520	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DY252_08525	COG0840	transmembrane signaling receptor activity
DY252_08535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DY252_08535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DY252_08545	COG0519	Catalyzes the synthesis of GMP from XMP
DY252_08565	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_08575	COG3655	Transcriptional regulator
DY252_08590	COG2217	Heavy metal translocating P-type atpase
DY252_08595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_08605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DY252_08610	COG0765	amino acid transport
DY252_08615	COG0765	amino acid transport
DY252_08665	COG1012	belongs to the aldehyde dehydrogenase family
DY252_08670	COG0596	Alpha beta hydrolase
DY252_08675	COG0494	nUDIX hydrolase
DY252_08695	COG1653	transport
DY252_08710	COG0366	Alpha amylase catalytic
DY252_08715	COG3842	ATPase activity
DY252_08720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DY252_08725	COG0363	glucosamine-6-phosphate deaminase activity
DY252_08730	COG0129	dihydroxy-acid dehydratase activity
DY252_08735	COG0837	glucose binding
DY252_08740	COG0800	Aldolase
DY252_08755	COG1595	DNA-templated transcription, initiation
DY252_08795	COG2719	SpoVR family
DY252_08800	COG2718	Belongs to the UPF0229 family
DY252_08805	COG2766	serine protein kinase
DY252_08820	COG0251	oxidation-reduction process
DY252_08840	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DY252_08880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DY252_08895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DY252_08905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DY252_08915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DY252_08925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DY252_08930	COG0222	ribosome binding
DY252_08935	COG0085	RNA polymerase activity
DY252_08940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DY252_08960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DY252_08970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DY252_08975	COG0088	Forms part of the polypeptide exit tunnel
DY252_08980	COG0089	rRNA binding
DY252_08990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DY252_09000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DY252_09005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DY252_09010	COG0255	Belongs to the universal ribosomal protein uL29 family
DY252_09025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DY252_09030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DY252_09040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DY252_09050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DY252_09060	COG1841	ribosomal large subunit assembly
DY252_09065	COG0200	Binds to the 23S rRNA
DY252_09070	COG0201	protein transport
DY252_09075	COG0563	adenylate kinase activity
DY252_09080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DY252_09085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DY252_09095	COG0203	ribosomal protein L17
DY252_09100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DY252_09110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DY252_09115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DY252_09125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DY252_09130	COG0564	pseudouridine synthase activity
DY252_09140	COG0546	phosphoglycolate phosphatase activity
DY252_09155	COG0412	Dienelactone hydrolase
DY252_09160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_09190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DY252_09215	COG1254	Belongs to the acylphosphatase family
DY252_09245	COG0277	FAD linked oxidase domain protein
DY252_09250	COG0009	L-threonylcarbamoyladenylate synthase
DY252_09270	COG1355	regulation of microtubule-based process
DY252_09300	COG0456	acetyltransferase
DY252_09310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DY252_09315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DY252_09320	COG2927	DNA polymerase III (CHI subunit)
DY252_09325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DY252_09330	COG2011	ABC-type metal ion transport system permease component
DY252_09350	COG0477	Major facilitator Superfamily
DY252_09365	COG3093	addiction module antidote protein HigA
DY252_09370	COG3549	Plasmid maintenance system killer
DY252_09390	COG0488	(ABC) transporter
DY252_09395	COG0105	UTP biosynthetic process
DY252_09425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DY252_09430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DY252_09440	COG0628	permease
DY252_09445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DY252_09450	COG4067	protein conserved in archaea
DY252_09450	COG0189	ligase activity
DY252_09455	COG0189	ligase activity
DY252_09465	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DY252_09475	COG1309	transcriptional regulator
DY252_09510	COG0248	Ppx GppA phosphatase
DY252_09545	COG0640	Transcriptional regulator
DY252_09550	COG0123	including yeast histone deacetylase and acetoin utilization protein
DY252_09570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DY252_09585	COG0318	PFAM AMP-dependent synthetase and ligase
DY252_09610	COG1802	Transcriptional regulator
DY252_09615	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DY252_09650	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DY252_09655	COG1295	ribonuclease BN
DY252_09670	COG1022	Amp-dependent synthetase and ligase
DY252_09680	COG3264	Mechanosensitive ion channel
DY252_09680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DY252_09685	COG0484	heat shock protein binding
DY252_09700	COG0640	Transcriptional regulator
DY252_09720	COG2135	peptidase activity
DY252_09725	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_09730	COG3153	acetyltransferase
DY252_09745	COG0156	8-amino-7-oxononanoate synthase activity
DY252_09760	COG0583	DNA-binding transcription factor activity
DY252_09775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DY252_09785	COG0659	secondary active sulfate transmembrane transporter activity
DY252_09790	COG1024	Enoyl-CoA hydratase
DY252_09800	COG2814	Major facilitator Superfamily
DY252_09810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_09815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DY252_09820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_09845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DY252_09860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DY252_09865	COG0583	DNA-binding transcription factor activity
DY252_09875	COG3622	Belongs to the hyi family
DY252_09885	COG2186	Transcriptional regulator
DY252_09895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DY252_09915	COG0840	transmembrane signaling receptor activity
DY252_09915	COG0840	transmembrane signaling receptor activity
DY252_09960	COG3135	benzoate transporter
DY252_09965	COG0450	alkyl hydroperoxide reductase
DY252_09990	COG0483	inositol monophosphate 1-phosphatase activity
DY252_09995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DY252_10000	COG0352	thiamine-phosphate diphosphorylase activity
DY252_10030	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DY252_10040	COG1692	metallophosphoesterase
DY252_10045	COG0840	transmembrane signaling receptor activity
DY252_10055	COG0217	transcriptional regulatory protein
DY252_10065	COG0632	four-way junction helicase activity
DY252_10070	COG2255	four-way junction helicase activity
DY252_10075	COG0824	Thioesterase
DY252_10085	COG0848	biopolymer transport protein
DY252_10100	COG2885	chlorophyll binding
DY252_10110	COG0037	tRNA processing
DY252_10115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DY252_10120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DY252_10125	COG0745	RESPONSE REGULATOR receiver
DY252_10135	COG2205	protein histidine kinase activity
DY252_10145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DY252_10150	COG0351	phosphomethylpyrimidine kinase
DY252_10150	COG0352	thiamine-phosphate diphosphorylase activity
DY252_10170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DY252_10185	COG0686	Belongs to the AlaDH PNT family
DY252_10190	COG1522	sequence-specific DNA binding
DY252_10200	COG1177	transmembrane transport
DY252_10205	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_10210	COG3842	ATPase activity
DY252_10215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DY252_10220	COG0174	glutamine synthetase
DY252_10230	COG4948	Mandelate Racemase Muconate Lactonizing
DY252_10270	COG0842	Transport permease protein
DY252_10275	COG0842	Transport permease protein
DY252_10275	COG1129	ABC transporter
DY252_10280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DY252_10285	COG1408	metallophosphoesterase
DY252_10290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DY252_10295	COG0583	DNA-binding transcription factor activity
DY252_10335	COG0277	FAD linked oxidase domain protein
DY252_10335	COG0247	lactate metabolic process
DY252_10345	COG2831	hemolysin activation secretion protein
DY252_10360	COG1116	anion transmembrane transporter activity
DY252_10365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_10370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DY252_10385	COG3668	Plasmid stabilization system
DY252_10395	COG0583	DNA-binding transcription factor activity
DY252_10410	COG0110	maltose O-acetyltransferase activity
DY252_10430	COG0642	Histidine kinase
DY252_10435	COG1609	Transcriptional regulator
DY252_10445	COG4149	molybdate abc transporter
DY252_10455	COG3842	ATPase activity
DY252_10460	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DY252_10480	COG1090	epimerase
DY252_10490	COG0583	DNA-binding transcription factor activity
DY252_10505	COG2194	sulfuric ester hydrolase activity
DY252_10515	COG0432	Pfam Uncharacterised protein family UPF0047
DY252_10540	COG1335	isochorismatase
DY252_10545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DY252_10570	COG4765	Protein conserved in bacteria
DY252_10580	COG2353	YceI-like domain
DY252_10585	COG3038	cytochrome b561
DY252_10595	COG0840	transmembrane signaling receptor activity
DY252_10600	COG0840	transmembrane signaling receptor activity
DY252_10600	COG0840	transmembrane signaling receptor activity
DY252_10605	COG0400	carboxylic ester hydrolase activity
DY252_10610	COG0534	Mate efflux family protein
DY252_10615	COG1522	sequence-specific DNA binding
DY252_10625	COG1959	2 iron, 2 sulfur cluster binding
DY252_10630	COG0513	Belongs to the DEAD box helicase family
DY252_10650	COG0187	DNA topoisomerase II activity
DY252_10655	COG1607	acyl-coa hydrolase
DY252_10665	COG4608	Belongs to the ABC transporter superfamily
DY252_10670	COG0444	Belongs to the ABC transporter superfamily
DY252_10680	COG0601	transmembrane transport
DY252_10720	COG0469	pyruvate kinase activity
DY252_10740	COG0693	protein deglycase activity
DY252_10745	COG0668	transmembrane transport
DY252_10760	COG1832	CoA-binding protein
DY252_10765	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DY252_10775	COG1280	lysine exporter protein (LysE YggA)
DY252_10800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DY252_10805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DY252_10810	COG1304	FMN binding
DY252_10825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DY252_10870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DY252_10875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DY252_10880	COG1858	cytochrome C peroxidase
DY252_10885	COG2084	Dehydrogenase
DY252_10890	COG3243	poly(R)-hydroxyalkanoic acid synthase
DY252_10900	COG0436	Aminotransferase
DY252_10910	COG1494	fructose-1,6-bisphosphatase
DY252_10915	COG0443	Heat shock 70 kDa protein
DY252_10935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DY252_10935	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DY252_10940	COG2223	nitrite transmembrane transporter activity
DY252_10960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DY252_10980	COG1234	tRNA 3'-trailer cleavage
DY252_10990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DY252_10995	COG0840	transmembrane signaling receptor activity
DY252_10995	COG2972	Histidine kinase
DY252_11015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DY252_11035	COG0626	cystathionine gamma-synthase activity
DY252_11040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_11050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DY252_11055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DY252_11060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_11065	COG1116	anion transmembrane transporter activity
DY252_11085	COG0123	including yeast histone deacetylase and acetoin utilization protein
DY252_11125	COG0656	L-ascorbic acid biosynthetic process
DY252_11130	COG0523	cobalamin synthesis protein
DY252_11150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DY252_11155	COG0626	cystathionine gamma-synthase activity
DY252_11160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DY252_11165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DY252_11180	COG2897	thiosulfate sulfurtransferase activity
DY252_11185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DY252_11210	COG1280	lysine exporter protein (LysE YggA)
DY252_11215	COG1620	l-lactate permease
DY252_11220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DY252_11235	COG2814	Major facilitator Superfamily
DY252_11245	COG0494	nUDIX hydrolase
DY252_11250	COG3706	GGDEF domain
DY252_11260	COG2195	Cleaves the N-terminal amino acid of tripeptides
DY252_11265	COG0484	heat shock protein binding
DY252_11310	COG0730	response to heat
DY252_11315	COG0425	Belongs to the sulfur carrier protein TusA family
DY252_11320	COG2153	protein acetylation
DY252_11335	COG5001	Diguanylate cyclase
DY252_11335	COG5002	protein histidine kinase activity
DY252_11340	COG3706	GGDEF domain
DY252_11355	COG1067	ATP-dependent peptidase activity
DY252_11360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DY252_11370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DY252_11385	COG0471	metal ion transport
DY252_11385	COG3273	potassium ion transport
DY252_11415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DY252_11420	COG0564	pseudouridine synthase activity
DY252_11440	COG4175	Glycine betaine
DY252_11445	COG4176	ABC-type proline glycine betaine transport system permease component
DY252_11465	COG1840	ABC-type Fe3 transport system, periplasmic component
DY252_11470	COG1840	ABC-type Fe3 transport system, periplasmic component
DY252_11485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DY252_11530	COG0747	negative chemotaxis
DY252_11535	COG0601	transmembrane transport
DY252_11540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DY252_11555	COG2814	Major facilitator Superfamily
DY252_11560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_11560	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DY252_11565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DY252_11570	COG1393	Belongs to the ArsC family
DY252_11575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DY252_11580	COG0405	Gamma-glutamyltransferase
DY252_11605	COG0793	Belongs to the peptidase S41A family
DY252_11620	COG0557	exoribonuclease II activity
DY252_11625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DY252_11630	COG0758	DNA mediated transformation
DY252_11630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DY252_11640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DY252_11660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DY252_11665	COG3842	ATPase activity
DY252_11675	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_11685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DY252_11690	COG0154	amidase activity
DY252_11695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DY252_11700	COG0431	NADPH-dependent FMN reductase
DY252_11705	COG2217	Heavy metal translocating P-type atpase
DY252_11715	COG0583	DNA-binding transcription factor activity
DY252_11735	COG2995	paraquat-inducible protein a
DY252_11740	COG3008	intermembrane lipid transfer
DY252_11800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_11805	COG0737	Belongs to the 5'-nucleotidase family
DY252_11835	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DY252_11840	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DY252_11850	COG1127	ABC transporter
DY252_11855	COG1126	abc transporter atp-binding protein
DY252_11860	COG0765	amino acid transport
DY252_11865	COG4597	amino acid ABC transporter
DY252_11870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DY252_11875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DY252_11880	COG0521	Mo-molybdopterin cofactor biosynthetic process
DY252_11905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DY252_11945	COG2814	Major facilitator Superfamily
DY252_11970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DY252_11980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DY252_11995	COG0310	cobalt ion transport
DY252_12030	COG0045	succinate-CoA ligase (ADP-forming) activity
DY252_12030	COG1042	CoA-binding domain protein
DY252_12030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DY252_12055	COG0840	transmembrane signaling receptor activity
DY252_12060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DY252_12070	COG1538	Outer membrane efflux protein
DY252_12080	COG0525	valine-tRNA ligase activity
DY252_12090	COG0512	Glutamine amidotransferase of anthranilate synthase
DY252_12105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DY252_12115	COG0316	Belongs to the HesB IscA family
DY252_12130	COG1472	Belongs to the glycosyl hydrolase 3 family
DY252_12135	COG1994	Peptidase M50
DY252_12140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DY252_12145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DY252_12150	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DY252_12155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DY252_12160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DY252_12165	COG0805	protein transport
DY252_12185	COG4942	peptidase
DY252_12210	COG3737	Protein of unknown function (DUF498/DUF598)
DY252_12215	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DY252_12220	COG0668	transmembrane transport
DY252_12245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DY252_12250	COG0191	fructose-bisphosphate aldolase activity
DY252_12255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DY252_12270	COG1175	transmembrane transport
DY252_12275	COG0395	ABC-type sugar transport system, permease component
DY252_12285	COG1956	GAF domain-containing protein
DY252_12290	COG0629	single-stranded DNA binding
DY252_12305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DY252_12325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DY252_12335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DY252_12345	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DY252_12350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DY252_12395	COG2824	Alkylphosphonate utilization operon protein PhnA
DY252_12405	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DY252_12410	COG2951	lytic endotransglycosylase activity
DY252_12420	COG1686	Belongs to the peptidase S11 family
DY252_12425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DY252_12440	COG0084	hydrolase, TatD family'
DY252_12445	COG0321	lipoyl(octanoyl) transferase activity
DY252_12445	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DY252_12470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DY252_12475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DY252_12520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DY252_12530	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_12535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DY252_12545	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_12550	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_12555	COG1129	ABC transporter
DY252_12565	COG4585	Histidine kinase
DY252_12575	COG0642	Histidine kinase
DY252_12595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DY252_12620	COG0840	transmembrane signaling receptor activity
DY252_12625	COG3180	Ammonia monooxygenase
DY252_12630	COG0446	pyridine nucleotide-disulphide oxidoreductase
DY252_12645	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DY252_12680	COG0785	Cytochrome C biogenesis protein
DY252_12695	COG2391	methyltransferase activity
DY252_12715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DY252_12720	COG1917	Cupin 2, conserved barrel domain protein
DY252_12725	COG0527	aspartate kinase activity
DY252_12730	COG3956	TIGRFAM MazG family protein
DY252_12735	COG0483	inositol monophosphate 1-phosphatase activity
DY252_12740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DY252_12755	COG0569	domain protein
DY252_12760	COG2204	response regulator
DY252_12800	COG1324	tolerance protein
DY252_12825	COG0776	regulation of translation
DY252_12830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DY252_12835	COG0416	fatty acid biosynthetic process
DY252_12855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DY252_12860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DY252_12865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DY252_12870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DY252_12870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DY252_12880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DY252_12880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DY252_12885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DY252_12890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DY252_12895	COG0698	ribose 5-phosphate isomerase
DY252_12905	COG0683	leucine binding
DY252_12945	COG1024	Enoyl-CoA hydratase
DY252_12950	COG1960	acyl-CoA dehydrogenase activity
DY252_12960	COG1349	DNA-binding transcription factor activity
DY252_12970	COG0113	porphobilinogen synthase activity
DY252_12975	COG1011	Hydrolase
DY252_12985	COG0318	PFAM AMP-dependent synthetase and ligase
DY252_12995	COG1012	belongs to the aldehyde dehydrogenase family
DY252_13005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DY252_13010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DY252_13015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DY252_13020	COG1360	Flagellar Motor Protein
DY252_13030	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_13035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_13045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DY252_13050	COG1381	Involved in DNA repair and RecF pathway recombination
DY252_13070	COG0681	Belongs to the peptidase S26 family
DY252_13075	COG0736	holo-[acyl-carrier-protein] synthase activity
DY252_13080	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DY252_13110	COG1573	uracil-dna glycosylase
DY252_13115	COG0514	ATP-dependent DNA helicase (RecQ)
DY252_13120	COG0386	Belongs to the glutathione peroxidase family
DY252_13125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DY252_13130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DY252_13135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DY252_13140	COG1196	nuclear chromosome segregation
DY252_13140	COG0741	lytic transglycosylase activity
DY252_13140	COG0739	heme binding
DY252_13155	COG0739	heme binding
DY252_13160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DY252_13165	COG1058	Belongs to the CinA family
DY252_13165	COG1546	Belongs to the CinA family
DY252_13170	COG2867	negative regulation of translational initiation
DY252_13175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DY252_13180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DY252_13185	COG0508	dehydrogenase complex catalyzes the overall conversion of
DY252_13190	COG0508	dehydrogenase complex catalyzes the overall conversion of
DY252_13190	COG0022	dehydrogenase e1 component
DY252_13195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DY252_13205	COG0148	phosphopyruvate hydratase activity
DY252_13225	COG0149	triose-phosphate isomerase activity
DY252_13230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DY252_13235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DY252_13240	COG2861	carbohydrate metabolic process
DY252_13260	COG0315	cyclic pyranopterin monophosphate synthase activity
DY252_13270	COG2333	competence protein COMEC
DY252_13270	COG0658	competence protein
DY252_13275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DY252_13280	COG0372	Belongs to the citrate synthase family
DY252_13290	COG1280	lysine exporter protein (LysE YggA)
DY252_13295	COG0583	DNA-binding transcription factor activity
DY252_13305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DY252_13310	COG3494	Protein of unknown function (DUF1009)
DY252_13315	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DY252_13340	COG0750	zinc metalloprotease
DY252_13345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DY252_13350	COG0575	Belongs to the CDS family
DY252_13355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DY252_13370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DY252_13375	COG0052	Belongs to the universal ribosomal protein uS2 family
DY252_13380	COG0587	DNA-directed DNA polymerase activity
DY252_13395	COG0442	prolyl-tRNA aminoacylation
DY252_13445	COG0713	ATP synthesis coupled electron transport
DY252_13455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DY252_13460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DY252_13465	COG1034	ATP synthesis coupled electron transport
DY252_13470	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DY252_13475	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DY252_13490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DY252_13495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DY252_13505	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DY252_13525	COG0776	regulation of translation
DY252_13560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DY252_13560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DY252_13570	COG2202	Pas domain
DY252_13570	COG2205	protein histidine kinase activity
DY252_13585	COG2217	Heavy metal translocating P-type atpase
DY252_13590	COG2193	ferroxidase activity
DY252_13600	COG3046	protein related to deoxyribodipyrimidine photolyase
DY252_13605	COG0415	Belongs to the DNA photolyase family
DY252_13635	COG0395	ABC-type sugar transport system, permease component
DY252_13640	COG3842	ATPase activity
DY252_13650	COG0745	RESPONSE REGULATOR receiver
DY252_13660	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DY252_13695	COG0010	Belongs to the arginase family
DY252_13700	COG1012	belongs to the aldehyde dehydrogenase family
DY252_13705	COG1917	Cupin 2, conserved barrel domain protein
DY252_13705	COG1396	sequence-specific DNA binding
DY252_13710	COG0174	glutamine synthetase
DY252_13735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_13750	COG1012	belongs to the aldehyde dehydrogenase family
DY252_13765	COG4176	ABC-type proline glycine betaine transport system permease component
DY252_13770	COG4175	Glycine betaine
DY252_13770	COG0517	IMP dehydrogenase activity
DY252_13780	COG0583	DNA-binding transcription factor activity
DY252_13790	COG1177	transmembrane transport
DY252_13800	COG3842	ATPase activity
DY252_13805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DY252_13810	COG3246	L-lysine catabolic process to acetate
DY252_13825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DY252_13830	COG0251	oxidation-reduction process
DY252_13850	COG2423	ornithine cyclodeaminase activity
DY252_13865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_13870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_13880	COG1737	Transcriptional regulator
DY252_13890	COG0729	surface antigen
DY252_13940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DY252_13945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DY252_13950	COG3485	protocatechuate 3,4-dioxygenase
DY252_13955	COG3485	protocatechuate 3,4-dioxygenase
DY252_13965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DY252_13970	COG0583	DNA-binding transcription factor activity
DY252_13985	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_13995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DY252_14000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_14000	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DY252_14015	COG2264	protein methyltransferase activity
DY252_14025	COG2814	Major facilitator Superfamily
DY252_14035	COG2375	cellular response to nickel ion
DY252_14090	COG3769	mannosylglycerate metabolic process
DY252_14095	COG1215	transferase activity, transferring glycosyl groups
DY252_14110	COG0366	Alpha amylase catalytic
DY252_14125	COG1247	-acetyltransferase
DY252_14180	COG2186	Transcriptional regulator
DY252_14185	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_14190	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_14195	COG1129	ABC transporter
DY252_14200	COG1879	ABC-type sugar transport system periplasmic component
DY252_14215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_14225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_14230	COG1802	Transcriptional regulator
DY252_14255	COG3220	belongs to the UPF0276 family
DY252_14305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DY252_14320	COG0308	aminopeptidase N
DY252_14340	COG1280	lysine exporter protein (LysE YggA)
DY252_14355	COG2205	protein histidine kinase activity
DY252_14365	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_14370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_14380	COG0840	transmembrane signaling receptor activity
DY252_14390	COG1629	transport
DY252_14395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DY252_14410	COG0848	biopolymer transport protein
DY252_14420	COG0811	peptide transport
DY252_14435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DY252_14440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DY252_14445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DY252_14475	COG0418	dihydroorotase activity
DY252_14510	COG0583	DNA-binding transcription factor activity
DY252_14520	COG0436	Aminotransferase
DY252_14540	COG0457	Tetratricopeptide repeat
DY252_14545	COG5001	Diguanylate cyclase
DY252_14545	COG5002	protein histidine kinase activity
DY252_14545	COG3447	MASE1 domain protein
DY252_14555	COG1765	OsmC-like protein
DY252_14570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DY252_14575	COG0457	Tetratricopeptide repeat
DY252_14590	COG3300	MHYT domain
DY252_14590	COG5001	Diguanylate cyclase
DY252_14605	COG1802	Transcriptional regulator
DY252_14610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_14620	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_14640	COG0583	DNA-binding transcription factor activity
DY252_14665	COG4177	L-phenylalanine transmembrane transporter activity
DY252_14725	COG0482	sulfurtransferase activity
DY252_14730	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DY252_14735	COG2975	iron-sulfur cluster assembly
DY252_14740	COG0633	Ferredoxin
DY252_14750	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DY252_14755	COG0316	Belongs to the HesB IscA family
DY252_14760	COG0822	iron-sulfur transferase activity
DY252_14770	COG1104	cysteine desulfurase activity
DY252_14775	COG1959	2 iron, 2 sulfur cluster binding
DY252_14780	COG1045	serine acetyltransferase
DY252_14785	COG2945	thiolester hydrolase activity
DY252_14790	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DY252_14805	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DY252_14810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DY252_14820	COG2833	Protein of unknown function (DUF455)
DY252_14830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DY252_14840	COG2972	Histidine kinase
DY252_14840	COG0840	transmembrane signaling receptor activity
DY252_14865	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DY252_14870	COG0860	N-Acetylmuramoyl-L-alanine amidase
DY252_14875	COG1530	ribonuclease E activity
DY252_14900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DY252_14900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DY252_14910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DY252_14915	COG0511	ligase activity, forming carbon-carbon bonds
DY252_14920	COG0439	Biotin carboxylase
DY252_14925	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DY252_14935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DY252_14945	COG0840	transmembrane signaling receptor activity
DY252_14965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DY252_14980	COG1686	Belongs to the peptidase S11 family
DY252_14990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DY252_15000	COG0484	heat shock protein binding
DY252_15010	COG1192	Involved in chromosome partitioning
DY252_15020	COG0579	oxidoreductase
DY252_15025	COG2342	PFAM TM1410 hypothetical-related protein
DY252_15035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DY252_15040	COG0028	Belongs to the TPP enzyme family
DY252_15090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DY252_15095	COG1024	Enoyl-CoA hydratase
DY252_15125	COG0840	transmembrane signaling receptor activity
DY252_15135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DY252_15165	COG2084	Dehydrogenase
DY252_15170	COG0793	Belongs to the peptidase S41A family
DY252_15175	COG1960	acyl-CoA dehydrogenase activity
DY252_15180	COG0795	lipopolysaccharide-transporting ATPase activity
DY252_15190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DY252_15195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DY252_15200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DY252_15205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DY252_15210	COG0194	GDP metabolic process
DY252_15215	COG1561	YicC-like family, N-terminal region
DY252_15220	COG0300	oxidoreductase activity
DY252_15225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DY252_15230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DY252_15245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DY252_15255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DY252_15270	COG0305	Participates in initiation and elongation during chromosome replication
DY252_15275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DY252_15280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DY252_15285	COG1127	ABC transporter
DY252_15300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DY252_15305	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_15340	COG1160	GTP binding
DY252_15405	COG2132	Multicopper oxidase
DY252_15460	COG0789	Transcriptional regulator
DY252_15470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DY252_15485	COG1902	pentaerythritol trinitrate reductase activity
DY252_15495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DY252_15505	COG0789	Transcriptional regulator
DY252_15530	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DY252_15535	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DY252_15540	COG1091	dTDP-4-dehydrorhamnose reductase activity
DY252_15555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DY252_15560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DY252_15565	COG0546	phosphoglycolate phosphatase activity
DY252_15575	COG4214	carbohydrate transport
DY252_15585	COG4213	ABC transporter substrate-binding protein
DY252_15600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DY252_15610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DY252_15625	COG1234	tRNA 3'-trailer cleavage
DY252_15640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DY252_15725	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DY252_15730	COG2205	protein histidine kinase activity
DY252_15735	COG0745	RESPONSE REGULATOR receiver
DY252_15750	COG1283	sodium-dependent phosphate transmembrane transporter activity
DY252_15755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DY252_15760	COG0367	asparagine synthase
DY252_15765	COG3284	Transcriptional regulator
DY252_15770	COG1012	belongs to the aldehyde dehydrogenase family
DY252_15780	COG2855	membrane
DY252_15790	COG1271	oxidase subunit
DY252_15795	COG1294	oxidase, subunit
DY252_15805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DY252_15815	COG0175	sulfate reduction
DY252_15835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DY252_15850	COG2827	Endonuclease containing a URI domain
DY252_15855	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_15865	COG0800	Aldolase
DY252_15870	COG3734	2-keto-3-deoxy-galactonokinase
DY252_15880	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DY252_15900	COG1431	PFAM Stem cell self-renewal protein Piwi
DY252_15955	COG3938	Belongs to the proline racemase family
DY252_15960	COG2186	Transcriptional regulator
DY252_15970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_15975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DY252_15990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DY252_16010	COG2814	Major facilitator Superfamily
DY252_16035	COG3842	ATPase activity
DY252_16050	COG0395	ABC-type sugar transport system, permease component
DY252_16070	COG0746	molybdenum cofactor guanylyltransferase activity
DY252_16080	COG0583	DNA-binding transcription factor activity
DY252_16085	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_16105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_16110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_16130	COG1309	transcriptional regulator
DY252_16150	COG0493	'glutamate synthase
DY252_16155	COG1607	acyl-coa hydrolase
DY252_16160	COG1363	Peptidase, m42
DY252_16170	COG4608	Belongs to the ABC transporter superfamily
DY252_16175	COG0444	Belongs to the ABC transporter superfamily
DY252_16185	COG0747	negative chemotaxis
DY252_16205	COG1115	amino acid carrier protein
DY252_16225	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DY252_16250	COG3386	PFAM SMP-30 Gluconolaconase
DY252_16255	COG1120	ATPase activity
DY252_16265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DY252_16270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DY252_16300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DY252_16315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_16320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DY252_16330	COG3386	PFAM SMP-30 Gluconolaconase
DY252_16335	COG2186	Transcriptional regulator
DY252_16340	COG2017	converts alpha-aldose to the beta-anomer
DY252_16345	COG2186	Transcriptional regulator
DY252_16350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DY252_16355	COG1069	ribulokinase activity
DY252_16360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DY252_16365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DY252_16390	COG1595	DNA-templated transcription, initiation
DY252_16410	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DY252_16425	COG0583	DNA-binding transcription factor activity
DY252_16430	COG0697	spore germination
DY252_16465	COG0167	dihydroorotate dehydrogenase activity
DY252_16470	COG1902	pentaerythritol trinitrate reductase activity
DY252_16500	COG0384	phenazine biosynthesis protein PhzF
DY252_16510	COG3550	peptidyl-serine autophosphorylation
DY252_16530	COG3311	Transcriptional regulator
DY252_16670	COG0483	inositol monophosphate 1-phosphatase activity
DY252_16675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DY252_16695	COG0506	proline dehydrogenase activity
DY252_16700	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DY252_16705	COG3852	Histidine kinase
DY252_16730	COG1846	Transcriptional regulator
DY252_16740	COG1764	response to oxidative stress
DY252_16755	COG1238	metal cluster binding
DY252_16770	COG1917	Cupin 2, conserved barrel domain protein
DY252_16770	COG2207	Transcriptional regulator
DY252_16775	COG1199	ATP-dependent helicase activity
DY252_16780	COG1819	glycosyl
DY252_16795	COG2217	Heavy metal translocating P-type atpase
DY252_16800	COG3247	response to pH
DY252_16805	COG0583	DNA-binding transcription factor activity
DY252_16825	COG5001	Diguanylate cyclase
DY252_16835	COG2084	Dehydrogenase
DY252_16860	COG0583	DNA-binding transcription factor activity
DY252_16865	COG2271	Major facilitator Superfamily
DY252_16880	COG0583	DNA-binding transcription factor activity
DY252_16885	COG1643	Atp-dependent helicase
DY252_16955	COG0438	transferase activity, transferring glycosyl groups
DY252_16975	COG0495	leucyl-tRNA aminoacylation
DY252_17005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DY252_17010	COG2226	methyltransferase
DY252_17020	COG0720	synthase
DY252_17025	COG0602	queuosine metabolic process
DY252_17080	COG0688	phosphatidylethanolamine metabolic process
DY252_17105	COG3634	alkyl hydroperoxide reductase activity
DY252_17110	COG1349	DNA-binding transcription factor activity
DY252_17130	COG0395	ABC-type sugar transport system, permease component
DY252_17135	COG0583	DNA-binding transcription factor activity
DY252_17160	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DY252_17185	COG0384	phenazine biosynthesis protein PhzF
DY252_17205	COG0538	isocitrate dehydrogenase activity
DY252_17255	COG0655	NAD(P)H dehydrogenase (quinone) activity
DY252_17260	COG0584	glycerophosphoryl diester phosphodiesterase
DY252_17270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DY252_17275	COG2207	Transcriptional regulator
DY252_17275	COG1609	Transcriptional regulator
DY252_17280	COG1309	transcriptional regulator
DY252_17290	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_17295	COG1177	transmembrane transport
DY252_17300	COG3842	ATPase activity
DY252_17320	COG4325	translation initiation factor activity
DY252_17350	COG5487	UPF0391 membrane protein
DY252_17370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DY252_17435	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DY252_17445	COG1987	bacterial-type flagellum assembly
DY252_17450	COG1677	Flagellar hook-basal body complex protein FliE
DY252_17455	COG1558	bacterial-type flagellum-dependent cell motility
DY252_17460	COG1815	bacterial-type flagellum-dependent cell motility
DY252_17470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DY252_17485	COG1338	Plays a role in the flagellum-specific transport system
DY252_17490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_17520	COG0745	RESPONSE REGULATOR receiver
DY252_17545	COG4786	Flagellar basal body rod
DY252_17550	COG4786	Flagellar basal body rod
DY252_17560	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DY252_17565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DY252_17575	COG1706	bacterial-type flagellum-dependent cell motility
DY252_17580	COG3951	Flagellar rod assembly protein muramidase FlgJ
DY252_17595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DY252_17610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DY252_17615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DY252_17620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DY252_17640	COG1516	flagellar protein fliS
DY252_17650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DY252_17655	COG1749	Flagellar hook protein flgE
DY252_17660	COG1766	The M ring may be actively involved in energy transduction
DY252_17670	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DY252_17675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DY252_17680	COG2204	response regulator
DY252_17685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DY252_17695	COG2894	cell division
DY252_17710	COG3128	pkhd-type hydroxylase
DY252_17715	COG4136	ATPase activity
DY252_17720	COG4135	transport system, permease component
DY252_17725	COG4134	Bacterial extracellular solute-binding protein
DY252_17730	COG0861	Integral membrane protein TerC family
DY252_17750	COG1157	protein secretion by the type III secretion system
DY252_17755	COG0745	RESPONSE REGULATOR receiver
DY252_17775	COG0745	RESPONSE REGULATOR receiver
DY252_17785	COG2198	Histidine kinase
DY252_17785	COG0643	Histidine kinase
DY252_17830	COG2962	Rard protein
DY252_17835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DY252_17840	COG0668	transmembrane transport
DY252_17850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DY252_17865	COG0300	oxidoreductase activity
DY252_17870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DY252_17890	COG0477	Major facilitator Superfamily
DY252_17905	COG0789	Transcriptional regulator
DY252_17920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DY252_17930	COG0393	Putative heavy-metal-binding
DY252_17935	COG0393	Putative heavy-metal-binding
DY252_17950	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DY252_17965	COG1739	Uncharacterized protein family UPF0029
DY252_17970	COG1609	Transcriptional regulator
DY252_17975	COG3265	gluconokinase activity
DY252_17980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_18015	COG0175	sulfate reduction
DY252_18025	COG1612	heme a metabolic process
DY252_18035	COG0312	modulator of DNA gyrase
DY252_18065	COG0747	negative chemotaxis
DY252_18070	COG0601	transmembrane transport
DY252_18075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DY252_18080	COG0444	Belongs to the ABC transporter superfamily
DY252_18085	COG4608	Belongs to the ABC transporter superfamily
DY252_18090	COG1280	lysine exporter protein (LysE YggA)
DY252_18110	COG0114	fumarate hydratase activity
DY252_18115	COG1349	DNA-binding transcription factor activity
DY252_18130	COG3639	organic phosphonate transmembrane transporter activity
DY252_18155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DY252_18160	COG2264	protein methyltransferase activity
DY252_18195	COG0312	modulator of DNA gyrase
DY252_18200	COG0840	transmembrane signaling receptor activity
DY252_18205	COG1597	lipid kinase activity
DY252_18215	COG0438	transferase activity, transferring glycosyl groups
DY252_18225	COG1132	(ABC) transporter
DY252_18235	COG1519	Transferase
DY252_18240	COG1663	tetraacyldisaccharide 4'-kinase activity
DY252_18255	COG0405	Gamma-glutamyltransferase
DY252_18265	COG1570	exodeoxyribonuclease VII activity
DY252_18270	COG0151	Belongs to the GarS family
DY252_18275	COG1120	ATPase activity
DY252_18280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DY252_18290	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DY252_18295	COG2207	Transcriptional regulator
DY252_18300	COG4221	oxidoreductase activity
DY252_18315	COG0590	tRNA wobble adenosine to inosine editing
DY252_18320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DY252_18330	COG0742	ribosomal rna small subunit methyltransferase
DY252_18355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DY252_18380	COG0783	Belongs to the Dps family
DY252_18390	COG0552	protein localization to endoplasmic reticulum
DY252_18395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DY252_18400	COG3706	GGDEF domain
DY252_18405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DY252_18410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DY252_18415	COG0706	membrane insertase activity
DY252_18420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DY252_18430	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DY252_18450	COG2274	protein secretion by the type I secretion system
DY252_18485	COG0840	transmembrane signaling receptor activity
DY252_18555	COG2239	Acts as a magnesium transporter
DY252_18560	COG0281	malic enzyme
DY252_18560	COG0280	phosphate acetyltransferase
DY252_18575	COG3706	GGDEF domain
DY252_18605	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DY252_18620	COG0745	RESPONSE REGULATOR receiver
DY252_18620	COG3706	GGDEF domain
DY252_18630	COG2249	NAD(P)H dehydrogenase (quinone) activity
DY252_18645	COG1733	regulation of RNA biosynthetic process
DY252_18650	COG0456	acetyltransferase
DY252_18680	COG1012	belongs to the aldehyde dehydrogenase family
DY252_18685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DY252_18695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_18700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DY252_18705	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DY252_18710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_18720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DY252_18725	COG2423	ornithine cyclodeaminase activity
DY252_18730	COG0006	proline dipeptidase activity
DY252_18735	COG3608	succinylglutamate desuccinylase aspartoacylase
DY252_18740	COG1522	sequence-specific DNA binding
DY252_18770	COG0154	amidase activity
DY252_18785	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_18800	COG0673	inositol 2-dehydrogenase activity
DY252_18810	COG1879	ABC-type sugar transport system periplasmic component
DY252_18815	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_18820	COG1129	ABC transporter
DY252_18825	COG1609	Transcriptional regulator
DY252_18835	COG0019	diaminopimelate decarboxylase activity
DY252_18850	COG1609	Transcriptional regulator
DY252_18860	COG1175	transmembrane transport
DY252_18865	COG0395	ABC-type sugar transport system, permease component
DY252_18910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DY252_18915	COG0745	RESPONSE REGULATOR receiver
DY252_18920	COG5002	protein histidine kinase activity
DY252_18950	COG1802	Transcriptional regulator
DY252_18955	COG0405	Gamma-glutamyltransferase
DY252_18960	COG0625	glutathione transferase activity
DY252_18970	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DY252_18985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_19010	COG1522	sequence-specific DNA binding
DY252_19015	COG0410	ABC transporter
DY252_19020	COG0411	ABC transporter
DY252_19030	COG0559	Belongs to the binding-protein-dependent transport system permease family
DY252_19075	COG0179	Fumarylacetoacetate (FAA) hydrolase
DY252_19095	COG0402	S-adenosylhomocysteine deaminase activity
DY252_19100	COG1228	amidohydrolase
DY252_19105	COG2986	histidine ammonia-lyase
DY252_19120	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_19130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_19175	COG1024	Enoyl-CoA hydratase
DY252_19180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_19210	COG3335	DDE superfamily endonuclease
DY252_19240	COG3039	Transposase
DY252_19245	COG2204	response regulator
DY252_19270	COG3547	Transposase (IS116 IS110 IS902 family)
DY252_19275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_19290	COG1960	acyl-CoA dehydrogenase activity
DY252_19295	COG1070	Carbohydrate kinase
DY252_19300	COG1830	Aldolase
DY252_19305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DY252_19310	COG0667	Aldo Keto reductase
DY252_19315	COG2390	Transcriptional regulator
DY252_19320	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_19325	COG1129	ABC transporter
DY252_19340	COG2204	response regulator
DY252_19365	COG1129	ABC transporter
DY252_19370	COG0410	ABC transporter
DY252_19375	COG1454	alcohol dehydrogenase
DY252_19380	COG1012	belongs to the aldehyde dehydrogenase family
DY252_19385	COG1454	alcohol dehydrogenase
DY252_19390	COG0667	Aldo Keto reductase
DY252_19400	COG2376	Dihydroxyacetone kinase
DY252_19410	COG1129	ABC transporter
DY252_19420	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_19440	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DY252_19460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DY252_19475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DY252_19495	COG0271	Belongs to the BolA IbaG family
DY252_19525	COG4536	flavin adenine dinucleotide binding
DY252_19530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DY252_19545	COG4974	Belongs to the 'phage' integrase family
DY252_19550	COG2199	diguanylate cyclase activity
DY252_19550	COG2200	EAL domain
DY252_19550	COG2202	Pas domain
DY252_19585	COG0714	Associated with various cellular activities
DY252_19610	COG0435	Glutathione S-transferase
DY252_19620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DY252_19625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DY252_19645	COG1196	nuclear chromosome segregation
DY252_19660	COG1194	a g-specific adenine glycosylase
DY252_19670	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DY252_19690	COG4603	Belongs to the binding-protein-dependent transport system permease family
DY252_19700	COG0402	S-adenosylhomocysteine deaminase activity
DY252_19705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DY252_19715	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DY252_19740	COG0679	Auxin Efflux Carrier
DY252_19745	COG5265	(ABC) transporter
DY252_19755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DY252_19760	COG0799	negative regulation of ribosome biogenesis
DY252_19770	COG0840	transmembrane signaling receptor activity
DY252_19780	COG1349	DNA-binding transcription factor activity
DY252_19785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DY252_19795	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_19800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DY252_19805	COG1760	l-serine dehydratase
DY252_19810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DY252_19815	COG4942	peptidase
DY252_19820	COG0793	Belongs to the peptidase S41A family
DY252_19830	COG0494	nUDIX hydrolase
DY252_19840	COG4106	trans-aconitate 2-methyltransferase activity
DY252_19865	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DY252_19875	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DY252_19930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_19945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DY252_19950	COG0228	four-way junction DNA binding
DY252_19980	COG0066	3-isopropylmalate dehydratase activity
DY252_19990	COG1595	DNA-templated transcription, initiation
DY252_19995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DY252_20005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DY252_20010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DY252_20040	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_20050	COG0471	metal ion transport
DY252_20050	COG3273	potassium ion transport
DY252_20060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DY252_20065	COG1872	DUF167
DY252_20075	COG0519	Catalyzes the synthesis of GMP from XMP
DY252_20080	COG1609	Transcriptional regulator
DY252_20095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DY252_20160	COG0798	PFAM Bile acid sodium symporter
DY252_20175	COG1702	phosphate starvation-inducible protein PhoH
DY252_20180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DY252_20185	COG1138	Cytochrome C-type biogenesis protein
DY252_20190	COG4235	cytochrome complex assembly
DY252_20195	COG0784	Response regulator, receiver
DY252_20205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DY252_20210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DY252_20215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DY252_20220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DY252_20225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DY252_20230	COG0625	glutathione transferase activity
DY252_20250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DY252_20260	COG4974	Belongs to the 'phage' integrase family
DY252_20275	COG0625	glutathione transferase activity
DY252_20285	COG0174	glutamine synthetase
DY252_20295	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DY252_20305	COG1051	belongs to the nudix hydrolase family
DY252_20310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DY252_20315	COG3264	Mechanosensitive ion channel
DY252_20315	COG1196	nuclear chromosome segregation
DY252_20325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DY252_20330	COG0039	L-malate dehydrogenase activity
DY252_20335	COG0045	succinate-CoA ligase (ADP-forming) activity
DY252_20340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DY252_20345	COG0567	Dehydrogenase, E1 component
DY252_20350	COG0508	dehydrogenase complex catalyzes the overall conversion of
DY252_20360	COG1803	Methylglyoxal synthase
DY252_20370	COG0564	pseudouridine synthase activity
DY252_20395	COG2211	Major facilitator Superfamily
DY252_20400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DY252_20410	COG1233	COG1233 Phytoene dehydrogenase and related
DY252_20415	COG1595	DNA-templated transcription, initiation
DY252_20420	COG3806	Anti-sigma factor
DY252_20425	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DY252_20430	COG1187	pseudouridine synthase activity
DY252_20450	COG3706	GGDEF domain
DY252_20455	COG0745	RESPONSE REGULATOR receiver
DY252_20455	COG3706	GGDEF domain
DY252_20460	COG2081	HI0933 family
DY252_20470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_20490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DY252_20495	COG0024	Methionine aminopeptidase
DY252_20505	COG3485	protocatechuate 3,4-dioxygenase
DY252_20510	COG3485	protocatechuate 3,4-dioxygenase
DY252_20515	COG0583	DNA-binding transcription factor activity
DY252_20525	COG2188	Transcriptional regulator
DY252_20530	COG3624	Phosphonate C-P lyase system protein PhnG
DY252_20540	COG3626	phosphonate metabolism
DY252_20545	COG3627	carbon phosphorus lyase activity
DY252_20550	COG4107	phosphonate C-P lyase system protein PhnK
DY252_20555	COG4778	phosphonate C-P lyase system protein PhnL
DY252_20560	COG3454	Phosphonate metabolism
DY252_20565	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DY252_20565	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DY252_20570	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DY252_20580	COG3639	organic phosphonate transmembrane transporter activity
DY252_20585	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DY252_20590	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DY252_20595	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DY252_20605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DY252_20630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DY252_20650	COG0824	Thioesterase
DY252_20650	COG1250	3-hydroxyacyl-CoA dehydrogenase
DY252_20655	COG3246	L-lysine catabolic process to acetate
DY252_20675	COG0039	L-malate dehydrogenase activity
DY252_20680	COG4638	Rieske (2fe-2S)
DY252_20685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DY252_20695	COG2086	electron transfer activity
DY252_20705	COG0788	formyltetrahydrofolate deformylase activity
DY252_20715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DY252_20750	COG0666	response to abiotic stimulus
DY252_20790	COG3547	Transposase (IS116 IS110 IS902 family)
DY252_20830	COG2217	Heavy metal translocating P-type atpase
DY252_20835	COG0640	Transcriptional regulator
DY252_20865	COG0789	Transcriptional regulator
DY252_20870	COG2814	Major facilitator Superfamily
DY252_20875	COG1937	Protein conserved in bacteria
DY252_20880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DY252_20880	COG0678	peroxiredoxin activity
DY252_20890	COG0640	Transcriptional regulator
DY252_20900	COG1230	cation diffusion facilitator family transporter
DY252_20910	COG0583	DNA-binding transcription factor activity
DY252_20920	COG2948	multi-organism process
DY252_20935	COG3846	protein secretion by the type IV secretion system
DY252_20950	COG3451	type IV secretory pathway VirB4
DY252_20965	COG4962	Type ii secretion system protein e
DY252_21015	COG2963	transposase activity
DY252_21050	COG0741	lytic transglycosylase activity
DY252_21075	COG1192	Involved in chromosome partitioning
DY252_21105	COG5489	Protein of unknown function (DUF736)
DY252_21135	COG0667	Aldo Keto reductase
DY252_21175	COG0464	growth
DY252_21195	COG1309	transcriptional regulator
DY252_21270	COG0582	viral genome integration into host DNA
DY252_21290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DY252_21345	COG5489	Protein of unknown function (DUF736)
DY252_21400	COG3550	peptidyl-serine autophosphorylation
DY252_21405	COG3620	sequence-specific DNA binding
DY252_21415	COG4227	nucleotidyltransferase activity
DY252_21470	COG0584	glycerophosphoryl diester phosphodiesterase
DY252_21475	COG0534	Mate efflux family protein
DY252_21495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DY252_21510	COG0302	gtp cyclohydrolase
DY252_21535	COG3852	Histidine kinase
DY252_21540	COG2818	Glycosylase
DY252_21550	COG1309	transcriptional regulator
DY252_21555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DY252_21565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DY252_21575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DY252_21580	COG1525	nuclease
DY252_21605	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DY252_21625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DY252_21640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_21645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DY252_21645	COG0512	Glutamine amidotransferase of anthranilate synthase
DY252_21655	COG3237	CsbD-like
DY252_21670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DY252_21680	COG5001	Diguanylate cyclase
DY252_21690	COG2171	N-acyltransferase activity
DY252_21695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DY252_21715	COG0583	DNA-binding transcription factor activity
DY252_21730	COG2816	NAD+ diphosphatase activity
DY252_21740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DY252_21745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DY252_21750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DY252_21755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DY252_21765	COG1802	Transcriptional regulator
DY252_21775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_21785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_21825	COG2205	protein histidine kinase activity
DY252_21830	COG1078	dGTPase activity
DY252_21850	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DY252_21855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DY252_21860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DY252_21865	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DY252_21865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DY252_21870	COG1660	Displays ATPase and GTPase activities
DY252_21875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DY252_21880	COG2205	protein histidine kinase activity
DY252_21885	COG0745	RESPONSE REGULATOR receiver
DY252_21890	COG4191	Histidine kinase
DY252_21895	COG2204	response regulator
DY252_21930	COG0583	DNA-binding transcription factor activity
DY252_21940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DY252_21950	COG0242	peptide deformylase activity
DY252_21955	COG1322	Protein conserved in bacteria
DY252_21960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DY252_21965	COG0583	DNA-binding transcription factor activity
DY252_21970	COG3181	Tripartite tricarboxylate transporter family receptor
DY252_21990	COG0473	3-isopropylmalate dehydrogenase activity
DY252_21995	COG0583	DNA-binding transcription factor activity
DY252_22010	COG1846	Transcriptional regulator
DY252_22020	COG0659	secondary active sulfate transmembrane transporter activity
DY252_22025	COG0589	response to stress
DY252_22045	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DY252_22050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DY252_22055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DY252_22060	COG0842	Transport permease protein
DY252_22065	COG2137	regulation of response to DNA damage stimulus
DY252_22070	COG1393	Belongs to the ArsC family
DY252_22085	COG1346	cytolysis
DY252_22110	COG0137	argininosuccinate synthase activity
DY252_22120	COG1280	lysine exporter protein (LysE YggA)
DY252_22125	COG0583	DNA-binding transcription factor activity
DY252_22160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity