locus-tag	class	description
IT893_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IT893_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IT893_00025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT893_00040	COG0235	Class ii aldolase
IT893_00050	COG0601	transmembrane transport
IT893_00055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT893_00060	COG4172	Belongs to the ABC transporter superfamily
IT893_00065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT893_00070	COG0154	amidase activity
IT893_00075	COG0438	transferase activity, transferring glycosyl groups
IT893_00080	COG1846	Transcriptional regulator
IT893_00105	COG2226	methyltransferase
IT893_00150	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IT893_00165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IT893_00180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT893_00200	COG0583	DNA-binding transcription factor activity
IT893_00205	COG1280	lysine exporter protein (LysE YggA)
IT893_00215	COG0137	argininosuccinate synthase activity
IT893_00230	COG1346	cytolysis
IT893_00245	COG1393	Belongs to the ArsC family
IT893_00250	COG2137	regulation of response to DNA damage stimulus
IT893_00255	COG0842	Transport permease protein
IT893_00260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IT893_00265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IT893_00270	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IT893_00290	COG0589	response to stress
IT893_00295	COG0659	secondary active sulfate transmembrane transporter activity
IT893_00300	COG0473	3-isopropylmalate dehydrogenase activity
IT893_00305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT893_00310	COG1322	Protein conserved in bacteria
IT893_00315	COG0242	peptide deformylase activity
IT893_00325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IT893_00335	COG0583	DNA-binding transcription factor activity
IT893_00360	COG2358	TRAP transporter, solute receptor (TAXI family
IT893_00365	COG2204	response regulator
IT893_00370	COG4191	Histidine kinase
IT893_00375	COG0745	RESPONSE REGULATOR receiver
IT893_00380	COG0642	Histidine kinase
IT893_00385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IT893_00390	COG1660	Displays ATPase and GTPase activities
IT893_00395	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT893_00395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT893_00400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT893_00405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT893_00410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IT893_00430	COG1078	dGTPase activity
IT893_00435	COG2205	protein histidine kinase activity
IT893_00480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT893_00490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_00490	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT893_00495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IT893_00500	COG1802	Transcriptional regulator
IT893_00510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IT893_00515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IT893_00520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IT893_00525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IT893_00535	COG2816	NAD+ diphosphatase activity
IT893_00550	COG0583	DNA-binding transcription factor activity
IT893_00560	COG0625	glutathione transferase activity
IT893_00575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT893_00580	COG2171	N-acyltransferase activity
IT893_00590	COG5001	Diguanylate cyclase
IT893_00600	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IT893_00615	COG3237	CsbD-like
IT893_00625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IT893_00625	COG0512	Glutamine amidotransferase of anthranilate synthase
IT893_00630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT893_00645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IT893_00670	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IT893_00695	COG1525	nuclease
IT893_00700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IT893_00710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IT893_00720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IT893_00725	COG1309	transcriptional regulator
IT893_00735	COG2818	Glycosylase
IT893_00740	COG3852	Histidine kinase
IT893_00765	COG0302	gtp cyclohydrolase
IT893_00775	COG3001	Fructosamine kinase
IT893_00780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IT893_00795	COG0534	Mate efflux family protein
IT893_00800	COG0584	glycerophosphoryl diester phosphodiesterase
IT893_00835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IT893_00845	COG0788	formyltetrahydrofolate deformylase activity
IT893_00855	COG2086	electron transfer activity
IT893_00865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT893_00870	COG4638	Rieske (2fe-2S)
IT893_00875	COG0039	L-malate dehydrogenase activity
IT893_00885	COG3246	L-lysine catabolic process to acetate
IT893_00890	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT893_00890	COG0824	Thioesterase
IT893_00915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT893_00920	COG0601	transmembrane transport
IT893_00935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT893_00945	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IT893_00950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IT893_00955	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IT893_00960	COG3639	organic phosphonate transmembrane transporter activity
IT893_00970	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IT893_00975	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IT893_00975	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IT893_00980	COG3454	Phosphonate metabolism
IT893_00985	COG4778	phosphonate C-P lyase system protein PhnL
IT893_00990	COG4107	phosphonate C-P lyase system protein PhnK
IT893_00995	COG3627	carbon phosphorus lyase activity
IT893_01000	COG3626	phosphonate metabolism
IT893_01010	COG3624	Phosphonate C-P lyase system protein PhnG
IT893_01015	COG2188	Transcriptional regulator
IT893_01025	COG0583	DNA-binding transcription factor activity
IT893_01030	COG3485	protocatechuate 3,4-dioxygenase
IT893_01035	COG3485	protocatechuate 3,4-dioxygenase
IT893_01045	COG0024	Methionine aminopeptidase
IT893_01050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IT893_01065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_01075	COG2081	HI0933 family
IT893_01085	COG3706	GGDEF domain
IT893_01110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IT893_01115	COG3806	Anti-sigma factor
IT893_01120	COG1595	DNA-templated transcription, initiation
IT893_01125	COG1233	COG1233 Phytoene dehydrogenase and related
IT893_01135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT893_01140	COG2211	Major facilitator Superfamily
IT893_01165	COG0564	pseudouridine synthase activity
IT893_01175	COG1803	Methylglyoxal synthase
IT893_01185	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT893_01190	COG0567	Dehydrogenase, E1 component
IT893_01195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IT893_01200	COG0045	succinate-CoA ligase (ADP-forming) activity
IT893_01205	COG0039	L-malate dehydrogenase activity
IT893_01210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IT893_01220	COG3264	Mechanosensitive ion channel
IT893_01220	COG1196	nuclear chromosome segregation
IT893_01225	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IT893_01230	COG1051	belongs to the nudix hydrolase family
IT893_01240	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IT893_01255	COG0174	glutamine synthetase
IT893_01265	COG0625	glutathione transferase activity
IT893_01275	COG4974	Belongs to the 'phage' integrase family
IT893_01285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT893_01305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IT893_01310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IT893_01335	COG0784	Response regulator, receiver
IT893_01340	COG4235	cytochrome complex assembly
IT893_01345	COG1138	Cytochrome C-type biogenesis protein
IT893_01350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IT893_01355	COG1702	phosphate starvation-inducible protein PhoH
IT893_01365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IT893_01370	COG0798	PFAM Bile acid sodium symporter
IT893_01430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT893_01435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT893_01450	COG1609	Transcriptional regulator
IT893_01455	COG0519	Catalyzes the synthesis of GMP from XMP
IT893_01465	COG1872	DUF167
IT893_01470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IT893_01475	COG3273	potassium ion transport
IT893_01475	COG0471	metal ion transport
IT893_01485	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_01495	COG0395	ABC-type sugar transport system, permease component
IT893_01515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IT893_01520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT893_01530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT893_01535	COG1595	DNA-templated transcription, initiation
IT893_01545	COG0066	3-isopropylmalate dehydratase activity
IT893_01575	COG0228	four-way junction DNA binding
IT893_01580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IT893_01595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT893_01645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IT893_01670	COG4106	trans-aconitate 2-methyltransferase activity
IT893_01680	COG0494	nUDIX hydrolase
IT893_01690	COG0793	Belongs to the peptidase S41A family
IT893_01695	COG4942	peptidase
IT893_01700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IT893_01705	COG1760	l-serine dehydratase
IT893_01710	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IT893_01715	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_01725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IT893_01730	COG1349	DNA-binding transcription factor activity
IT893_01735	COG0840	transmembrane signaling receptor activity
IT893_01740	COG0840	transmembrane signaling receptor activity
IT893_01750	COG0799	negative regulation of ribosome biogenesis
IT893_01755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IT893_01765	COG5265	(ABC) transporter
IT893_01770	COG0679	Auxin Efflux Carrier
IT893_01795	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IT893_01805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IT893_01810	COG0402	S-adenosylhomocysteine deaminase activity
IT893_01820	COG4603	Belongs to the binding-protein-dependent transport system permease family
IT893_01825	COG3845	ABC transporter
IT893_01830	COG1744	ABC transporter substrate-binding protein PnrA-like
IT893_01845	COG1194	a g-specific adenine glycosylase
IT893_01860	COG1196	nuclear chromosome segregation
IT893_01895	COG0435	Glutathione S-transferase
IT893_01920	COG0714	Associated with various cellular activities
IT893_01930	COG0494	nUDIX hydrolase
IT893_01955	COG2202	Pas domain
IT893_01955	COG2200	EAL domain
IT893_01955	COG2199	diguanylate cyclase activity
IT893_01960	COG4974	Belongs to the 'phage' integrase family
IT893_01980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IT893_01985	COG4536	flavin adenine dinucleotide binding
IT893_02005	COG2863	cytochrome
IT893_02015	COG0271	Belongs to the BolA IbaG family
IT893_02035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT893_02050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IT893_02060	COG4774	siderophore transport
IT893_02070	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IT893_02090	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT893_02100	COG1129	ABC transporter
IT893_02110	COG2376	Dihydroxyacetone kinase
IT893_02120	COG0667	Aldo Keto reductase
IT893_02130	COG1454	alcohol dehydrogenase
IT893_02135	COG1012	belongs to the aldehyde dehydrogenase family
IT893_02140	COG1454	alcohol dehydrogenase
IT893_02150	COG1129	ABC transporter
IT893_02185	COG1960	acyl-CoA dehydrogenase activity
IT893_02210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT893_02215	COG1024	Enoyl-CoA hydratase
IT893_02230	COG0183	Belongs to the thiolase family
IT893_02255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_02265	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT893_02280	COG2986	histidine ammonia-lyase
IT893_02285	COG1228	amidohydrolase
IT893_02290	COG0402	S-adenosylhomocysteine deaminase activity
IT893_02305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT893_02315	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT893_02345	COG0745	RESPONSE REGULATOR receiver
IT893_02375	COG0410	ABC transporter
IT893_02380	COG1522	sequence-specific DNA binding
IT893_02420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IT893_02430	COG0625	glutathione transferase activity
IT893_02435	COG0405	Gamma-glutamyltransferase
IT893_02440	COG1802	Transcriptional regulator
IT893_02470	COG1012	belongs to the aldehyde dehydrogenase family
IT893_02475	COG1177	transmembrane transport
IT893_02480	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT893_02485	COG3842	ATPase activity
IT893_02490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IT893_02500	COG5002	protein histidine kinase activity
IT893_02505	COG0745	RESPONSE REGULATOR receiver
IT893_02510	COG0746	molybdenum cofactor guanylyltransferase activity
IT893_02545	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IT893_02550	COG0395	ABC-type sugar transport system, permease component
IT893_02555	COG1175	transmembrane transport
IT893_02565	COG1609	Transcriptional regulator
IT893_02575	COG2814	Major facilitator Superfamily
IT893_02585	COG0019	diaminopimelate decarboxylase activity
IT893_02595	COG1609	Transcriptional regulator
IT893_02600	COG1129	ABC transporter
IT893_02605	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT893_02610	COG1879	ABC-type sugar transport system periplasmic component
IT893_02620	COG0673	inositol 2-dehydrogenase activity
IT893_02635	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT893_02650	COG0154	amidase activity
IT893_02680	COG1522	sequence-specific DNA binding
IT893_02685	COG3608	succinylglutamate desuccinylase aspartoacylase
IT893_02690	COG0006	proline dipeptidase activity
IT893_02695	COG2423	ornithine cyclodeaminase activity
IT893_02700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT893_02705	COG3473	Maleate cis-trans isomerase
IT893_02710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_02715	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT893_02720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT893_02725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT893_02735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT893_02740	COG1012	belongs to the aldehyde dehydrogenase family
IT893_02775	COG1733	regulation of RNA biosynthetic process
IT893_02790	COG2249	NAD(P)H dehydrogenase (quinone) activity
IT893_02810	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IT893_02855	COG0281	malic enzyme
IT893_02855	COG0280	phosphate acetyltransferase
IT893_02860	COG2239	Acts as a magnesium transporter
IT893_02960	COG2274	protein secretion by the type I secretion system
IT893_02980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IT893_02990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IT893_02995	COG0706	membrane insertase activity
IT893_03000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IT893_03005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IT893_03015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IT893_03020	COG0552	protein localization to endoplasmic reticulum
IT893_03030	COG0783	Belongs to the Dps family
IT893_03060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IT893_03085	COG0742	ribosomal rna small subunit methyltransferase
IT893_03090	COG1187	pseudouridine synthase activity
IT893_03095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IT893_03100	COG0590	tRNA wobble adenosine to inosine editing
IT893_03110	COG4221	oxidoreductase activity
IT893_03115	COG2207	Transcriptional regulator
IT893_03120	COG1959	2 iron, 2 sulfur cluster binding
IT893_03125	COG2264	protein methyltransferase activity
IT893_03130	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IT893_03140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT893_03145	COG1120	ATPase activity
IT893_03150	COG0151	Belongs to the GarS family
IT893_03155	COG1570	exodeoxyribonuclease VII activity
IT893_03165	COG0405	Gamma-glutamyltransferase
IT893_03180	COG1663	tetraacyldisaccharide 4'-kinase activity
IT893_03185	COG1519	Transferase
IT893_03195	COG1132	(ABC) transporter
IT893_03205	COG0438	transferase activity, transferring glycosyl groups
IT893_03215	COG1597	lipid kinase activity
IT893_03220	COG0840	transmembrane signaling receptor activity
IT893_03225	COG0312	modulator of DNA gyrase
IT893_03260	COG2264	protein methyltransferase activity
IT893_03265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IT893_03290	COG3639	organic phosphonate transmembrane transporter activity
IT893_03305	COG1349	DNA-binding transcription factor activity
IT893_03330	COG1280	lysine exporter protein (LysE YggA)
IT893_03335	COG4608	Belongs to the ABC transporter superfamily
IT893_03340	COG0444	Belongs to the ABC transporter superfamily
IT893_03345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT893_03350	COG0601	transmembrane transport
IT893_03355	COG0747	negative chemotaxis
IT893_03385	COG0312	modulator of DNA gyrase
IT893_03395	COG1612	heme a metabolic process
IT893_03405	COG0175	sulfate reduction
IT893_03435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT893_03440	COG3265	gluconokinase activity
IT893_03445	COG1609	Transcriptional regulator
IT893_03450	COG1739	Uncharacterized protein family UPF0029
IT893_03460	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IT893_03475	COG0367	asparagine synthase
IT893_03480	COG0463	Glycosyl transferase, family 2
IT893_03495	COG0393	Putative heavy-metal-binding
IT893_03500	COG0393	Putative heavy-metal-binding
IT893_03510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT893_03530	COG0477	Major facilitator Superfamily
IT893_03550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT893_03560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IT893_03570	COG0668	transmembrane transport
IT893_03575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IT893_03580	COG2962	Rard protein
IT893_03600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IT893_03620	COG0643	Histidine kinase
IT893_03620	COG0784	Response regulator, receiver
IT893_03620	COG2198	Histidine kinase
IT893_03630	COG0643	Histidine kinase
IT893_03630	COG0784	Response regulator, receiver
IT893_03630	COG2198	Histidine kinase
IT893_03645	COG2020	methyltransferase activity
IT893_03650	COG0745	RESPONSE REGULATOR receiver
IT893_03670	COG0861	Integral membrane protein TerC family
IT893_03675	COG4134	Bacterial extracellular solute-binding protein
IT893_03680	COG4135	transport system, permease component
IT893_03685	COG4136	ATPase activity
IT893_03715	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IT893_03720	COG2204	response regulator
IT893_03725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IT893_03730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IT893_03740	COG1766	The M ring may be actively involved in energy transduction
IT893_03745	COG1749	Flagellar hook protein flgE
IT893_03760	COG1516	flagellar protein fliS
IT893_03775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IT893_03780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IT893_03785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IT893_03800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IT893_03815	COG3951	Flagellar rod assembly protein muramidase FlgJ
IT893_03820	COG1706	bacterial-type flagellum-dependent cell motility
IT893_03835	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IT893_03845	COG4786	Flagellar basal body rod
IT893_03850	COG4786	Flagellar basal body rod
IT893_03875	COG0745	RESPONSE REGULATOR receiver
IT893_03905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT893_03910	COG1338	Plays a role in the flagellum-specific transport system
IT893_03925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IT893_03935	COG1815	bacterial-type flagellum-dependent cell motility
IT893_03940	COG1558	bacterial-type flagellum-dependent cell motility
IT893_03945	COG1677	Flagellar hook-basal body complex protein FliE
IT893_03950	COG1987	bacterial-type flagellum assembly
IT893_03960	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IT893_04025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IT893_04045	COG5487	UPF0391 membrane protein
IT893_04055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT893_04090	COG3842	ATPase activity
IT893_04100	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT893_04110	COG1309	transcriptional regulator
IT893_04130	COG0584	glycerophosphoryl diester phosphodiesterase
IT893_04135	COG0655	NAD(P)H dehydrogenase (quinone) activity
IT893_04185	COG0538	isocitrate dehydrogenase activity
IT893_04210	COG3119	arylsulfatase activity
IT893_04215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IT893_04245	COG0583	DNA-binding transcription factor activity
IT893_04255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT893_04260	COG3002	Belongs to the UPF0753 family
IT893_04265	COG0395	ABC-type sugar transport system, permease component
IT893_04285	COG1349	DNA-binding transcription factor activity
IT893_04290	COG3634	alkyl hydroperoxide reductase activity
IT893_04315	COG0688	phosphatidylethanolamine metabolic process
IT893_04350	COG2207	Transcriptional regulator
IT893_04350	COG3708	Transcriptional regulator
IT893_04370	COG0602	queuosine metabolic process
IT893_04375	COG0720	synthase
IT893_04380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IT893_04385	COG2226	methyltransferase
IT893_04390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IT893_04405	COG0495	leucyl-tRNA aminoacylation
IT893_04425	COG0438	transferase activity, transferring glycosyl groups
IT893_04450	COG0297	glycogen (starch) synthase activity
IT893_04450	COG0438	transferase activity, transferring glycosyl groups
IT893_04460	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IT893_04490	COG1643	Atp-dependent helicase
IT893_04515	COG0583	DNA-binding transcription factor activity
IT893_04525	COG2900	Belongs to the SlyX family
IT893_04540	COG2084	Dehydrogenase
IT893_04550	COG5001	Diguanylate cyclase
IT893_04570	COG0583	DNA-binding transcription factor activity
IT893_04575	COG3247	response to pH
IT893_04580	COG2217	Heavy metal translocating P-type atpase
IT893_04595	COG1819	glycosyl
IT893_04600	COG1199	ATP-dependent helicase activity
IT893_04605	COG2207	Transcriptional regulator
IT893_04605	COG1917	Cupin 2, conserved barrel domain protein
IT893_04620	COG1238	metal cluster binding
IT893_04625	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IT893_04630	COG1764	response to oxidative stress
IT893_04640	COG1846	Transcriptional regulator
IT893_04665	COG2200	EAL domain
IT893_04665	COG2199	diguanylate cyclase activity
IT893_04665	COG2202	Pas domain
IT893_04675	COG0506	proline dehydrogenase activity
IT893_04695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT893_04700	COG0483	inositol monophosphate 1-phosphatase activity
IT893_04845	COG3311	Transcriptional regulator
IT893_04865	COG3550	peptidyl-serine autophosphorylation
IT893_04875	COG0384	phenazine biosynthesis protein PhzF
IT893_04900	COG1902	pentaerythritol trinitrate reductase activity
IT893_04905	COG0167	dihydroorotate dehydrogenase activity
IT893_04925	COG0697	spore germination
IT893_04935	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IT893_04955	COG1595	DNA-templated transcription, initiation
IT893_04970	COG4774	siderophore transport
IT893_04985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT893_04990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT893_04995	COG1069	ribulokinase activity
IT893_05000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT893_05005	COG2186	Transcriptional regulator
IT893_05010	COG2017	converts alpha-aldose to the beta-anomer
IT893_05015	COG2186	Transcriptional regulator
IT893_05020	COG3386	PFAM SMP-30 Gluconolaconase
IT893_05030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT893_05035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT893_05050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT893_05085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT893_05100	COG1120	ATPase activity
IT893_05105	COG3386	PFAM SMP-30 Gluconolaconase
IT893_05115	COG4999	Histidine kinase
IT893_05115	COG2205	protein histidine kinase activity
IT893_05115	COG3437	response regulator, receiver
IT893_05115	COG3850	Histidine kinase
IT893_05120	COG0784	Response regulator, receiver
IT893_05120	COG2205	protein histidine kinase activity
IT893_05120	COG5002	protein histidine kinase activity
IT893_05140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IT893_05155	COG0826	peptidase U32
IT893_05160	COG1115	amino acid carrier protein
IT893_05180	COG0747	negative chemotaxis
IT893_05185	COG0601	transmembrane transport
IT893_05190	COG0444	Belongs to the ABC transporter superfamily
IT893_05195	COG4608	Belongs to the ABC transporter superfamily
IT893_05205	COG1363	Peptidase, m42
IT893_05210	COG1607	acyl-coa hydrolase
IT893_05215	COG0493	'glutamate synthase
IT893_05235	COG1309	transcriptional regulator
IT893_05240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT893_05255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT893_05260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT893_05295	COG0746	molybdenum cofactor guanylyltransferase activity
IT893_05320	COG0395	ABC-type sugar transport system, permease component
IT893_05335	COG3842	ATPase activity
IT893_05360	COG2814	Major facilitator Superfamily
IT893_05380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IT893_05395	COG0438	transferase activity, transferring glycosyl groups
IT893_05400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT893_05405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT893_05475	COG0546	phosphoglycolate phosphatase activity
IT893_05495	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IT893_05505	COG3734	2-keto-3-deoxy-galactonokinase
IT893_05510	COG0800	Aldolase
IT893_05535	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_05540	COG2827	Endonuclease containing a URI domain
IT893_05555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IT893_05575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT893_05585	COG0747	negative chemotaxis
IT893_05595	COG0587	DNA-directed DNA polymerase activity
IT893_05615	COG0175	sulfate reduction
IT893_05625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT893_05635	COG1294	oxidase, subunit
IT893_05640	COG1271	oxidase subunit
IT893_05650	COG0583	DNA-binding transcription factor activity
IT893_05655	COG2855	membrane
IT893_05665	COG1012	belongs to the aldehyde dehydrogenase family
IT893_05670	COG3284	Transcriptional regulator
IT893_05675	COG0367	asparagine synthase
IT893_05685	COG1283	sodium-dependent phosphate transmembrane transporter activity
IT893_05710	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IT893_05795	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IT893_05810	COG1234	tRNA 3'-trailer cleavage
IT893_05850	COG4213	ABC transporter substrate-binding protein
IT893_05860	COG4214	carbohydrate transport
IT893_05865	COG0129	dihydroxy-acid dehydratase activity
IT893_05870	COG0546	phosphoglycolate phosphatase activity
IT893_05880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IT893_05890	COG1091	dTDP-4-dehydrorhamnose reductase activity
IT893_05895	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IT893_05900	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IT893_05910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IT893_05920	COG1902	pentaerythritol trinitrate reductase activity
IT893_05935	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IT893_05940	COG4993	Dehydrogenase
IT893_05970	COG1160	GTP binding
IT893_05980	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_05985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IT893_06000	COG1127	ABC transporter
IT893_06005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IT893_06010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IT893_06015	COG0305	Participates in initiation and elongation during chromosome replication
IT893_06030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IT893_06040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IT893_06055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT893_06060	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IT893_06070	COG1561	YicC-like family, N-terminal region
IT893_06075	COG0194	GDP metabolic process
IT893_06080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IT893_06085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IT893_06090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT893_06095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IT893_06105	COG0795	lipopolysaccharide-transporting ATPase activity
IT893_06110	COG1960	acyl-CoA dehydrogenase activity
IT893_06115	COG0793	Belongs to the peptidase S41A family
IT893_06120	COG2084	Dehydrogenase
IT893_06135	COG0583	DNA-binding transcription factor activity
IT893_06150	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT893_06160	COG2972	Histidine kinase
IT893_06160	COG0840	transmembrane signaling receptor activity
IT893_06185	COG4770	biotin carboxylase activity
IT893_06190	COG1024	Enoyl-CoA hydratase
IT893_06195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT893_06240	COG0028	Belongs to the TPP enzyme family
IT893_06245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IT893_06255	COG2342	PFAM TM1410 hypothetical-related protein
IT893_06260	COG0579	oxidoreductase
IT893_06280	COG0484	heat shock protein binding
IT893_06285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IT893_06290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IT893_06300	COG1686	Belongs to the peptidase S11 family
IT893_06315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IT893_06345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT893_06355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IT893_06360	COG0439	Biotin carboxylase
IT893_06365	COG0511	ligase activity, forming carbon-carbon bonds
IT893_06370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IT893_06400	COG0436	Aminotransferase
IT893_06405	COG1530	ribonuclease E activity
IT893_06410	COG0860	N-Acetylmuramoyl-L-alanine amidase
IT893_06415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IT893_06435	COG0840	transmembrane signaling receptor activity
IT893_06435	COG2972	Histidine kinase
IT893_06455	COG2833	Protein of unknown function (DUF455)
IT893_06465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IT893_06470	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IT893_06485	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IT893_06490	COG2945	thiolester hydrolase activity
IT893_06495	COG1045	serine acetyltransferase
IT893_06500	COG1959	2 iron, 2 sulfur cluster binding
IT893_06505	COG1104	cysteine desulfurase activity
IT893_06515	COG0822	iron-sulfur transferase activity
IT893_06520	COG0316	Belongs to the HesB IscA family
IT893_06525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IT893_06535	COG0633	Ferredoxin
IT893_06540	COG2975	iron-sulfur cluster assembly
IT893_06545	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IT893_06550	COG0482	sulfurtransferase activity
IT893_06595	COG4177	L-phenylalanine transmembrane transporter activity
IT893_06615	COG0683	leucine binding
IT893_06620	COG0583	DNA-binding transcription factor activity
IT893_06630	COG1902	pentaerythritol trinitrate reductase activity
IT893_06630	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT893_06640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT893_06650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_06650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT893_06655	COG1802	Transcriptional regulator
IT893_06670	COG5001	Diguanylate cyclase
IT893_06670	COG3300	MHYT domain
IT893_06675	COG2207	Transcriptional regulator
IT893_06685	COG0457	Tetratricopeptide repeat
IT893_06690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IT893_06705	COG1765	OsmC-like protein
IT893_06715	COG3447	MASE1 domain protein
IT893_06715	COG5002	protein histidine kinase activity
IT893_06715	COG5001	Diguanylate cyclase
IT893_06720	COG0457	Tetratricopeptide repeat
IT893_06735	COG0436	Aminotransferase
IT893_06745	COG0583	DNA-binding transcription factor activity
IT893_06775	COG0418	dihydroorotase activity
IT893_06800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IT893_06805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IT893_06825	COG0811	peptide transport
IT893_06835	COG0848	biopolymer transport protein
IT893_06875	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT893_06880	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT893_06890	COG2205	protein histidine kinase activity
IT893_06905	COG1280	lysine exporter protein (LysE YggA)
IT893_06925	COG0308	aminopeptidase N
IT893_06940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IT893_07005	COG1802	Transcriptional regulator
IT893_07010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT893_07020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_07035	COG1879	ABC-type sugar transport system periplasmic component
IT893_07040	COG1129	ABC transporter
IT893_07045	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT893_07050	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT893_07055	COG2186	Transcriptional regulator
IT893_07120	COG1414	Transcriptional regulator
IT893_07130	COG0366	Alpha amylase catalytic
IT893_07145	COG1215	transferase activity, transferring glycosyl groups
IT893_07150	COG3769	mannosylglycerate metabolic process
IT893_07170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IT893_07195	COG1063	alcohol dehydrogenase
IT893_07205	COG2375	cellular response to nickel ion
IT893_07215	COG2814	Major facilitator Superfamily
IT893_07225	COG2264	protein methyltransferase activity
IT893_07235	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IT893_07235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT893_07240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IT893_07250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_07265	COG0583	DNA-binding transcription factor activity
IT893_07270	COG0596	Alpha beta hydrolase
IT893_07280	COG3485	protocatechuate 3,4-dioxygenase
IT893_07285	COG3485	protocatechuate 3,4-dioxygenase
IT893_07290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IT893_07295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IT893_07340	COG0729	surface antigen
IT893_07350	COG1737	Transcriptional regulator
IT893_07360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_07365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT893_07405	COG2423	ornithine cyclodeaminase activity
IT893_07425	COG0251	oxidation-reduction process
IT893_07430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT893_07445	COG3246	L-lysine catabolic process to acetate
IT893_07450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT893_07455	COG3842	ATPase activity
IT893_07475	COG0583	DNA-binding transcription factor activity
IT893_07485	COG4175	Glycine betaine
IT893_07485	COG0517	IMP dehydrogenase activity
IT893_07490	COG4176	ABC-type proline glycine betaine transport system permease component
IT893_07505	COG1012	belongs to the aldehyde dehydrogenase family
IT893_07520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT893_07545	COG0174	glutamine synthetase
IT893_07550	COG1917	Cupin 2, conserved barrel domain protein
IT893_07550	COG1396	sequence-specific DNA binding
IT893_07555	COG1012	belongs to the aldehyde dehydrogenase family
IT893_07560	COG0010	Belongs to the arginase family
IT893_07595	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IT893_07615	COG3842	ATPase activity
IT893_07620	COG0395	ABC-type sugar transport system, permease component
IT893_07625	COG1175	transmembrane transport
IT893_07635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IT893_07650	COG0415	Belongs to the DNA photolyase family
IT893_07655	COG3046	protein related to deoxyribodipyrimidine photolyase
IT893_07665	COG2193	ferroxidase activity
IT893_07670	COG2217	Heavy metal translocating P-type atpase
IT893_07685	COG2202	Pas domain
IT893_07685	COG2205	protein histidine kinase activity
IT893_07695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IT893_07695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IT893_07715	COG0740	serine-type endopeptidase activity
IT893_07730	COG0776	regulation of translation
IT893_07750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IT893_07760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT893_07765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT893_07780	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IT893_07785	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IT893_07790	COG1034	ATP synthesis coupled electron transport
IT893_07795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IT893_07800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT893_07810	COG0713	ATP synthesis coupled electron transport
IT893_07845	COG0346	lactoylglutathione lyase activity
IT893_07860	COG0442	prolyl-tRNA aminoacylation
IT893_07880	COG0052	Belongs to the universal ribosomal protein uS2 family
IT893_07885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IT893_07900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IT893_07910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IT893_07915	COG0750	zinc metalloprotease
IT893_07940	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT893_07945	COG3494	Protein of unknown function (DUF1009)
IT893_07950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT893_07960	COG0372	Belongs to the citrate synthase family
IT893_07965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT893_07970	COG0658	competence protein
IT893_07970	COG2333	competence protein COMEC
IT893_07980	COG0315	cyclic pyranopterin monophosphate synthase activity
IT893_08000	COG2861	carbohydrate metabolic process
IT893_08005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IT893_08015	COG0149	triose-phosphate isomerase activity
IT893_08035	COG0148	phosphopyruvate hydratase activity
IT893_08045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IT893_08050	COG0022	dehydrogenase e1 component
IT893_08050	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT893_08055	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT893_08060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT893_08065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IT893_08070	COG2867	negative regulation of translational initiation
IT893_08075	COG1058	Belongs to the CinA family
IT893_08075	COG1546	Belongs to the CinA family
IT893_08080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IT893_08085	COG0739	heme binding
IT893_08100	COG0741	lytic transglycosylase activity
IT893_08105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT893_08110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IT893_08115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IT893_08120	COG0386	Belongs to the glutathione peroxidase family
IT893_08125	COG0514	ATP-dependent DNA helicase (RecQ)
IT893_08130	COG1573	uracil-dna glycosylase
IT893_08160	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IT893_08165	COG0736	holo-[acyl-carrier-protein] synthase activity
IT893_08170	COG0681	Belongs to the peptidase S26 family
IT893_08195	COG1381	Involved in DNA repair and RecF pathway recombination
IT893_08200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IT893_08210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_08215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT893_08225	COG1360	Flagellar Motor Protein
IT893_08230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IT893_08235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IT893_08240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT893_08245	COG1012	belongs to the aldehyde dehydrogenase family
IT893_08255	COG0318	PFAM AMP-dependent synthetase and ligase
IT893_08265	COG1011	Hydrolase
IT893_08270	COG0113	porphobilinogen synthase activity
IT893_08280	COG1349	DNA-binding transcription factor activity
IT893_08290	COG1960	acyl-CoA dehydrogenase activity
IT893_08295	COG1024	Enoyl-CoA hydratase
IT893_08335	COG0683	leucine binding
IT893_08345	COG0698	ribose 5-phosphate isomerase
IT893_08350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IT893_08355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IT893_08360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT893_08360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT893_08370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT893_08370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT893_08375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IT893_08380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IT893_08385	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IT893_08405	COG0416	fatty acid biosynthetic process
IT893_08410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IT893_08415	COG0776	regulation of translation
IT893_08440	COG1324	tolerance protein
IT893_08480	COG2204	response regulator
IT893_08485	COG0569	domain protein
IT893_08500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IT893_08505	COG0483	inositol monophosphate 1-phosphatase activity
IT893_08510	COG3956	TIGRFAM MazG family protein
IT893_08515	COG0527	aspartate kinase activity
IT893_08520	COG1917	Cupin 2, conserved barrel domain protein
IT893_08525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IT893_08545	COG2391	methyltransferase activity
IT893_08560	COG0785	Cytochrome C biogenesis protein
IT893_08595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IT893_08610	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT893_08615	COG3180	Ammonia monooxygenase
IT893_08645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT893_08675	COG4585	Histidine kinase
IT893_08685	COG1129	ABC transporter
IT893_08690	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT893_08695	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT893_08705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT893_08710	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_08720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT893_08765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT893_08770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT893_08795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IT893_08795	COG0321	lipoyl(octanoyl) transferase activity
IT893_08800	COG0084	hydrolase, TatD family'
IT893_08815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IT893_08820	COG1686	Belongs to the peptidase S11 family
IT893_08830	COG2951	lytic endotransglycosylase activity
IT893_08835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IT893_08845	COG2824	Alkylphosphonate utilization operon protein PhnA
IT893_08890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IT893_08895	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IT893_08905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IT893_08915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IT893_08950	COG0629	single-stranded DNA binding
IT893_08955	COG1956	GAF domain-containing protein
IT893_08965	COG0395	ABC-type sugar transport system, permease component
IT893_08970	COG1175	transmembrane transport
IT893_08985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IT893_08990	COG0191	fructose-bisphosphate aldolase activity
IT893_08995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IT893_09020	COG0668	transmembrane transport
IT893_09025	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IT893_09030	COG3737	Protein of unknown function (DUF498/DUF598)
IT893_09045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT893_09050	COG1862	Preprotein translocase
IT893_09060	COG4942	peptidase
IT893_09080	COG0805	protein transport
IT893_09085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT893_09090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT893_09095	COG3842	ATPase activity
IT893_09100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IT893_09105	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IT893_09110	COG1994	Peptidase M50
IT893_09115	COG1472	Belongs to the glycosyl hydrolase 3 family
IT893_09130	COG0316	Belongs to the HesB IscA family
IT893_09140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT893_09155	COG0512	Glutamine amidotransferase of anthranilate synthase
IT893_09165	COG0525	valine-tRNA ligase activity
IT893_09175	COG1538	Outer membrane efflux protein
IT893_09180	COG1054	Belongs to the UPF0176 family
IT893_09185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IT893_09190	COG0840	transmembrane signaling receptor activity
IT893_09215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT893_09215	COG1042	CoA-binding domain protein
IT893_09215	COG0045	succinate-CoA ligase (ADP-forming) activity
IT893_09250	COG0310	cobalt ion transport
IT893_09265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IT893_09275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT893_09300	COG2814	Major facilitator Superfamily
IT893_09335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT893_09360	COG0521	Mo-molybdopterin cofactor biosynthetic process
IT893_09365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT893_09370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT893_09375	COG4597	amino acid ABC transporter
IT893_09380	COG0765	amino acid transport
IT893_09385	COG1126	abc transporter atp-binding protein
IT893_09390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IT893_09400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IT893_09405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IT893_09415	COG1079	Belongs to the binding-protein-dependent transport system permease family
IT893_09425	COG3845	ABC transporter
IT893_09430	COG1744	ABC transporter substrate-binding protein PnrA-like
IT893_09435	COG0737	Belongs to the 5'-nucleotidase family
IT893_09440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT893_09480	COG2814	Major facilitator Superfamily
IT893_09500	COG3008	intermembrane lipid transfer
IT893_09505	COG2995	paraquat-inducible protein a
IT893_09520	COG1435	thymidine kinase activity
IT893_09525	COG0583	DNA-binding transcription factor activity
IT893_09540	COG0431	NADPH-dependent FMN reductase
IT893_09545	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IT893_09550	COG0154	amidase activity
IT893_09555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IT893_09565	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT893_09575	COG3842	ATPase activity
IT893_09580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IT893_09600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IT893_09610	COG0758	DNA mediated transformation
IT893_09610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IT893_09615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IT893_09620	COG0557	exoribonuclease II activity
IT893_09640	COG0793	Belongs to the peptidase S41A family
IT893_09665	COG0405	Gamma-glutamyltransferase
IT893_09670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT893_09675	COG1393	Belongs to the ArsC family
IT893_09680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IT893_09685	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IT893_09685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT893_09690	COG2814	Major facilitator Superfamily
IT893_09705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT893_09710	COG0601	transmembrane transport
IT893_09715	COG0747	negative chemotaxis
IT893_09750	COG0438	transferase activity, transferring glycosyl groups
IT893_09760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IT893_09765	COG0303	'Molybdopterin
IT893_09775	COG1840	ABC-type Fe3 transport system, periplasmic component
IT893_09780	COG1840	ABC-type Fe3 transport system, periplasmic component
IT893_09800	COG4176	ABC-type proline glycine betaine transport system permease component
IT893_09805	COG4175	Glycine betaine
IT893_09820	COG0564	pseudouridine synthase activity
IT893_09845	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IT893_09855	COG3273	potassium ion transport
IT893_09855	COG0471	metal ion transport
IT893_09870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT893_09880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT893_09885	COG1067	ATP-dependent peptidase activity
IT893_09910	COG5001	Diguanylate cyclase
IT893_09910	COG5002	protein histidine kinase activity
IT893_09925	COG2153	protein acetylation
IT893_09930	COG0425	Belongs to the sulfur carrier protein TusA family
IT893_09935	COG0730	response to heat
IT893_09995	COG2195	Cleaves the N-terminal amino acid of tripeptides
IT893_10005	COG3706	GGDEF domain
IT893_10010	COG0494	nUDIX hydrolase
IT893_10020	COG2814	Major facilitator Superfamily
IT893_10035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT893_10040	COG1620	l-lactate permease
IT893_10050	COG1280	lysine exporter protein (LysE YggA)
IT893_10080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IT893_10085	COG2897	thiosulfate sulfurtransferase activity
IT893_10100	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IT893_10105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT893_10110	COG0626	cystathionine gamma-synthase activity
IT893_10120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT893_10140	COG0523	cobalamin synthesis protein
IT893_10145	COG0656	L-ascorbic acid biosynthetic process
IT893_10185	COG0123	including yeast histone deacetylase and acetoin utilization protein
IT893_10195	COG0372	Belongs to the citrate synthase family
IT893_10200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT893_10205	COG1116	anion transmembrane transporter activity
IT893_10210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT893_10215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT893_10220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IT893_10230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT893_10235	COG0626	cystathionine gamma-synthase activity
IT893_10255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IT893_10270	COG2972	Histidine kinase
IT893_10270	COG0840	transmembrane signaling receptor activity
IT893_10275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IT893_10285	COG3119	arylsulfatase activity
IT893_10290	COG1234	tRNA 3'-trailer cleavage
IT893_10310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT893_10335	COG2223	nitrite transmembrane transporter activity
IT893_10340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IT893_10340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IT893_10355	COG0443	Heat shock 70 kDa protein
IT893_10360	COG1494	fructose-1,6-bisphosphatase
IT893_10370	COG0436	Aminotransferase
IT893_10380	COG3243	poly(R)-hydroxyalkanoic acid synthase
IT893_10385	COG2084	Dehydrogenase
IT893_10390	COG1858	cytochrome C peroxidase
IT893_10395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IT893_10400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IT893_10415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT893_10460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IT893_10465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IT893_10490	COG1280	lysine exporter protein (LysE YggA)
IT893_10500	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IT893_10505	COG1832	CoA-binding protein
IT893_10520	COG0668	transmembrane transport
IT893_10525	COG0693	protein deglycase activity
IT893_10545	COG0469	pyruvate kinase activity
IT893_10585	COG0601	transmembrane transport
IT893_10590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT893_10595	COG0444	Belongs to the ABC transporter superfamily
IT893_10600	COG4608	Belongs to the ABC transporter superfamily
IT893_10620	COG0187	DNA topoisomerase II activity
IT893_10640	COG0513	Belongs to the DEAD box helicase family
IT893_10645	COG1959	2 iron, 2 sulfur cluster binding
IT893_10655	COG1522	sequence-specific DNA binding
IT893_10660	COG0534	Mate efflux family protein
IT893_10665	COG0400	carboxylic ester hydrolase activity
IT893_10685	COG3038	cytochrome b561
IT893_10690	COG2353	YceI-like domain
IT893_10695	COG4765	Protein conserved in bacteria
IT893_10715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IT893_10740	COG0432	Pfam Uncharacterised protein family UPF0047
IT893_10750	COG2194	sulfuric ester hydrolase activity
IT893_10765	COG0583	DNA-binding transcription factor activity
IT893_10775	COG1090	epimerase
IT893_10785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT893_10795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IT893_10800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IT893_10810	COG4149	molybdate abc transporter
IT893_10825	COG0642	Histidine kinase
IT893_10845	COG0110	maltose O-acetyltransferase activity
IT893_10870	COG0583	DNA-binding transcription factor activity
IT893_10890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT893_10900	COG1116	anion transmembrane transporter activity
IT893_10910	COG3210	domain, Protein
IT893_10910	COG3210	domain, Protein
IT893_10915	COG2831	hemolysin activation secretion protein
IT893_10920	COG0247	lactate metabolic process
IT893_10920	COG0277	FAD linked oxidase domain protein
IT893_10960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IT893_10965	COG1126	abc transporter atp-binding protein
IT893_10970	COG0765	amino acid transport
IT893_10985	COG0583	DNA-binding transcription factor activity
IT893_10990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IT893_10995	COG1408	metallophosphoesterase
IT893_11000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT893_11005	COG0842	Transport permease protein
IT893_11005	COG1129	ABC transporter
IT893_11010	COG0842	Transport permease protein
IT893_11040	COG4948	Mandelate Racemase Muconate Lactonizing
IT893_11050	COG0174	glutamine synthetase
IT893_11055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IT893_11060	COG3842	ATPase activity
IT893_11065	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT893_11070	COG1177	transmembrane transport
IT893_11080	COG1522	sequence-specific DNA binding
IT893_11085	COG0686	Belongs to the AlaDH PNT family
IT893_11090	COG0129	dihydroxy-acid dehydratase activity
IT893_11100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IT893_11120	COG0352	thiamine-phosphate diphosphorylase activity
IT893_11120	COG0351	phosphomethylpyrimidine kinase
IT893_11125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IT893_11130	COG2205	protein histidine kinase activity
IT893_11145	COG0745	RESPONSE REGULATOR receiver
IT893_11150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IT893_11155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IT893_11160	COG0037	tRNA processing
IT893_11170	COG2885	chlorophyll binding
IT893_11185	COG0848	biopolymer transport protein
IT893_11195	COG0824	Thioesterase
IT893_11200	COG2255	four-way junction helicase activity
IT893_11205	COG0632	four-way junction helicase activity
IT893_11215	COG0217	transcriptional regulatory protein
IT893_11230	COG1692	metallophosphoesterase
IT893_11240	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IT893_11270	COG0352	thiamine-phosphate diphosphorylase activity
IT893_11275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IT893_11280	COG0483	inositol monophosphate 1-phosphatase activity
IT893_11305	COG0450	alkyl hydroperoxide reductase
IT893_11310	COG3135	benzoate transporter
IT893_11375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IT893_11385	COG2186	Transcriptional regulator
IT893_11395	COG3622	Belongs to the hyi family
IT893_11400	COG0583	DNA-binding transcription factor activity
IT893_11405	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IT893_11420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IT893_11445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT893_11450	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT893_11455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_11465	COG2814	Major facilitator Superfamily
IT893_11475	COG1024	Enoyl-CoA hydratase
IT893_11480	COG0659	secondary active sulfate transmembrane transporter activity
IT893_11490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IT893_11505	COG0583	DNA-binding transcription factor activity
IT893_11520	COG0156	8-amino-7-oxononanoate synthase activity
IT893_11530	COG3153	acetyltransferase
IT893_11535	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_11540	COG2135	peptidase activity
IT893_11565	COG4520	surface antigen
IT893_11570	COG0484	heat shock protein binding
IT893_11575	COG3264	Mechanosensitive ion channel
IT893_11575	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IT893_11585	COG1022	Amp-dependent synthetase and ligase
IT893_11590	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_11600	COG1295	ribonuclease BN
IT893_11605	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IT893_11645	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IT893_11650	COG1802	Transcriptional regulator
IT893_11665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT893_11665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT893_11675	COG0318	PFAM AMP-dependent synthetase and ligase
IT893_11690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IT893_11710	COG0123	including yeast histone deacetylase and acetoin utilization protein
IT893_11720	COG0640	Transcriptional regulator
IT893_11750	COG0248	Ppx GppA phosphatase
IT893_11775	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IT893_11785	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IT893_11795	COG0583	DNA-binding transcription factor activity
IT893_11815	COG1309	transcriptional regulator
IT893_11820	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IT893_11830	COG0189	ligase activity
IT893_11835	COG4067	protein conserved in archaea
IT893_11835	COG0189	ligase activity
IT893_11840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IT893_11845	COG0628	permease
IT893_11855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IT893_11860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IT893_11885	COG0105	UTP biosynthetic process
IT893_11890	COG0488	(ABC) transporter
IT893_11915	COG2011	ABC-type metal ion transport system permease component
IT893_11920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IT893_11955	COG2927	DNA polymerase III (CHI subunit)
IT893_11960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT893_11990	COG1355	regulation of microtubule-based process
IT893_12005	COG4977	sequence-specific DNA binding
IT893_12025	COG0009	L-threonylcarbamoyladenylate synthase
IT893_12030	COG0277	FAD linked oxidase domain protein
IT893_12045	COG1254	Belongs to the acylphosphatase family
IT893_12065	COG4770	biotin carboxylase activity
IT893_12070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT893_12100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT893_12105	COG0412	Dienelactone hydrolase
IT893_12120	COG0546	phosphoglycolate phosphatase activity
IT893_12130	COG0564	pseudouridine synthase activity
IT893_12135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT893_12145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IT893_12150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IT893_12160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT893_12165	COG0203	ribosomal protein L17
IT893_12175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IT893_12180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IT893_12185	COG0563	adenylate kinase activity
IT893_12190	COG0201	protein transport
IT893_12195	COG0200	Binds to the 23S rRNA
IT893_12200	COG1841	ribosomal large subunit assembly
IT893_12210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IT893_12220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IT893_12230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IT893_12235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IT893_12250	COG0255	Belongs to the universal ribosomal protein uL29 family
IT893_12255	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IT893_12260	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IT893_12270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IT893_12280	COG0089	rRNA binding
IT893_12285	COG0088	Forms part of the polypeptide exit tunnel
IT893_12290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IT893_12305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IT893_12320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IT893_12325	COG0085	RNA polymerase activity
IT893_12330	COG0222	ribosome binding
IT893_12335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IT893_12345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IT893_12355	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IT893_12365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IT893_12380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT893_12405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT893_12425	COG0251	oxidation-reduction process
IT893_12440	COG2766	serine protein kinase
IT893_12445	COG2718	Belongs to the UPF0229 family
IT893_12450	COG2719	SpoVR family
IT893_12455	COG2132	Multicopper oxidase
IT893_12530	COG1595	DNA-templated transcription, initiation
IT893_12545	COG0800	Aldolase
IT893_12550	COG0837	glucose binding
IT893_12555	COG0129	dihydroxy-acid dehydratase activity
IT893_12560	COG0363	glucosamine-6-phosphate deaminase activity
IT893_12565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IT893_12580	COG0494	nUDIX hydrolase
IT893_12585	COG0596	Alpha beta hydrolase
IT893_12595	COG1012	belongs to the aldehyde dehydrogenase family
IT893_12640	COG4598	ABC transporter
IT893_12645	COG0765	amino acid transport
IT893_12650	COG0765	amino acid transport
IT893_12655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT893_12665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT893_12690	COG3655	Transcriptional regulator
IT893_12705	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_12710	COG0519	Catalyzes the synthesis of GMP from XMP
IT893_12720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IT893_12720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IT893_12730	COG0840	transmembrane signaling receptor activity
IT893_12735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IT893_12770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IT893_12775	COG1278	Cold shock
IT893_12785	COG3706	GGDEF domain
IT893_12800	COG1280	lysine exporter protein (LysE YggA)
IT893_12805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT893_12830	COG0768	penicillin binding
IT893_12835	COG0772	Belongs to the SEDS family
IT893_12845	COG1879	ABC-type sugar transport system periplasmic component
IT893_12870	COG2204	response regulator
IT893_12875	COG1366	Belongs to the anti-sigma-factor antagonist family
IT893_12890	COG5001	Diguanylate cyclase
IT893_12915	COG3180	Ammonia monooxygenase
IT893_12930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IT893_12930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IT893_12955	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IT893_12965	COG1309	transcriptional regulator
IT893_12995	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IT893_13000	COG1845	cytochrome c oxidase, subunit III
IT893_13005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT893_13010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IT893_13015	COG0477	Major facilitator Superfamily
IT893_13020	COG0625	glutathione transferase activity
IT893_13025	COG0625	glutathione transferase activity
IT893_13040	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IT893_13085	COG1671	Belongs to the UPF0178 family
IT893_13095	COG1278	Cold shock
IT893_13100	COG0513	Belongs to the DEAD box helicase family
IT893_13105	COG2391	methyltransferase activity
IT893_13145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT893_13145	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT893_13150	COG4311	Sarcosine oxidase, delta subunit
IT893_13155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT893_13160	COG4977	sequence-specific DNA binding
IT893_13175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT893_13200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT893_13210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IT893_13215	COG2218	PFAM glutamate synthase alpha subunit domain protein
IT893_13220	COG0069	glutamate synthase activity
IT893_13225	COG0174	glutamine synthetase
IT893_13235	COG0129	dihydroxy-acid dehydratase activity
IT893_13240	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_13245	COG4213	ABC transporter substrate-binding protein
IT893_13250	COG4214	carbohydrate transport
IT893_13255	COG1129	ABC transporter
IT893_13265	COG1940	carbohydrate kinase activity
IT893_13265	COG1846	Transcriptional regulator
IT893_13275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IT893_13290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT893_13295	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IT893_13305	COG3383	formate dehydrogenase (NAD+) activity
IT893_13320	COG0583	DNA-binding transcription factor activity
IT893_13325	COG2223	nitrite transmembrane transporter activity
IT893_13335	COG4191	Histidine kinase
IT893_13340	COG2204	response regulator
IT893_13345	COG4221	oxidoreductase activity
IT893_13355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT893_13360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT893_13375	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT893_13380	COG1177	transmembrane transport
IT893_13400	COG1129	ABC transporter
IT893_13420	COG3483	tryptophan 2,3-dioxygenase activity
IT893_13450	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_13505	COG0739	heme binding
IT893_13510	COG1132	(ABC) transporter
IT893_13520	COG0254	rRNA binding
IT893_13540	COG0604	alcohol dehydrogenase
IT893_13540	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_13540	COG3321	synthase
IT893_13550	COG1349	DNA-binding transcription factor activity
IT893_13555	COG0583	DNA-binding transcription factor activity
IT893_13600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IT893_13605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IT893_13620	COG0242	peptide deformylase activity
IT893_13635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IT893_13640	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_13665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IT893_13675	COG1022	Amp-dependent synthetase and ligase
IT893_13690	COG0542	response to heat
IT893_13710	COG2890	protein-(glutamine-N5) methyltransferase activity
IT893_13720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IT893_13725	COG0124	histidyl-tRNA synthetase
IT893_13730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IT893_13755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT893_13805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IT893_13810	COG0583	DNA-binding transcription factor activity
IT893_13815	COG0625	glutathione transferase activity
IT893_13820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT893_13820	COG1017	nitric oxide dioxygenase activity
IT893_13835	COG1489	DNA binding
IT893_13840	COG0024	Methionine aminopeptidase
IT893_13845	COG2003	Belongs to the UPF0758 family
IT893_13850	COG0346	lactoylglutathione lyase activity
IT893_13870	COG0601	transmembrane transport
IT893_13875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT893_13880	COG0444	Belongs to the ABC transporter superfamily
IT893_13890	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IT893_13895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IT893_13900	COG1881	PFAM PEBP family protein
IT893_13905	COG0583	DNA-binding transcription factor activity
IT893_13910	COG0697	spore germination
IT893_13915	COG0504	CTP synthase activity
IT893_13920	COG2197	response regulator
IT893_13935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IT893_13940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IT893_13945	COG0047	phosphoribosylformylglycinamidine synthase activity
IT893_13950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IT893_13955	COG0489	protein tyrosine kinase activity
IT893_13960	COG0330	HflC and HflK could
IT893_13980	COG0560	Phosphoserine phosphatase
IT893_13980	COG3830	Belongs to the UPF0237 family
IT893_13990	COG0028	Belongs to the TPP enzyme family
IT893_13995	COG0440	acetolactate synthase activity
IT893_14000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IT893_14005	COG2814	Major facilitator Superfamily
IT893_14010	COG2313	pseudouridylate synthase activity
IT893_14025	COG0415	Belongs to the DNA photolyase family
IT893_14050	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IT893_14055	COG1530	ribonuclease E activity
IT893_14075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IT893_14085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IT893_14140	COG0604	alcohol dehydrogenase
IT893_14145	COG3339	Conserved Protein
IT893_14155	COG0367	asparagine synthase
IT893_14160	COG0438	transferase activity, transferring glycosyl groups
IT893_14190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT893_14190	COG0574	Belongs to the PEP-utilizing enzyme family
IT893_14200	COG0752	glycyl-tRNA synthetase alpha subunit
IT893_14210	COG2890	protein-(glutamine-N5) methyltransferase activity
IT893_14220	COG0142	geranyltranstransferase activity
IT893_14235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT893_14255	COG3474	cytochrome
IT893_14265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IT893_14290	COG3246	L-lysine catabolic process to acetate
IT893_14295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT893_14305	COG0784	Response regulator, receiver
IT893_14305	COG5002	protein histidine kinase activity
IT893_14305	COG2205	protein histidine kinase activity
IT893_14320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IT893_14325	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IT893_14330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IT893_14335	COG0343	queuine tRNA-ribosyltransferase activity
IT893_14340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IT893_14345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IT893_14350	COG0306	phosphate transporter
IT893_14355	COG2982	Protein involved in outer membrane biogenesis
IT893_14375	COG0277	FAD linked oxidase domain protein
IT893_14390	COG0454	-acetyltransferase
IT893_14390	COG0456	acetyltransferase
IT893_14395	COG3811	Belongs to the UPF0386 family
IT893_14405	COG0069	glutamate synthase activity
IT893_14440	COG0840	transmembrane signaling receptor activity
IT893_14450	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IT893_14455	COG0488	(ABC) transporter
IT893_14465	COG3023	N-Acetylmuramoyl-L-alanine amidase
IT893_14480	COG1335	isochorismatase
IT893_14485	COG0598	Magnesium transport protein CorA
IT893_14510	COG0768	penicillin binding
IT893_14515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IT893_14545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IT893_14550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IT893_14555	COG1181	Belongs to the D-alanine--D-alanine ligase family
IT893_14560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IT893_14565	COG0849	cell division
IT893_14570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IT893_14580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT893_14605	COG0697	spore germination
IT893_14615	COG0667	Aldo Keto reductase
IT893_14620	COG0006	proline dipeptidase activity
IT893_14630	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_14645	COG0730	response to heat
IT893_14650	COG2264	protein methyltransferase activity
IT893_14655	COG0210	DNA helicase
IT893_14660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IT893_14670	COG0038	chloride channel
IT893_14675	COG2814	Major facilitator Superfamily
IT893_14680	COG1410	methionine synthase
IT893_14680	COG0646	methionine synthase
IT893_14695	COG2226	methyltransferase
IT893_14700	COG2853	Lipoprotein
IT893_14710	COG0488	(ABC) transporter
IT893_14720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT893_14725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IT893_14725	COG0517	IMP dehydrogenase activity
IT893_14730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IT893_14740	COG0725	ABC transporter, periplasmic molybdate-binding protein
IT893_14745	COG4149	molybdate abc transporter
IT893_14750	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IT893_14760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IT893_14770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT893_14770	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT893_14785	COG2207	Transcriptional regulator
IT893_14795	COG4638	Rieske (2fe-2S)
IT893_14800	COG0583	DNA-binding transcription factor activity
IT893_14805	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT893_14805	COG1902	pentaerythritol trinitrate reductase activity
IT893_14815	COG1116	anion transmembrane transporter activity
IT893_14815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT893_14825	COG2223	nitrite transmembrane transporter activity
IT893_14835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT893_14840	COG2146	nitrite reductase [NAD(P)H] activity
IT893_14845	COG0243	molybdopterin cofactor binding
IT893_14850	COG1648	precorrin-2 dehydrogenase activity
IT893_14850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IT893_14855	COG3718	enzyme involved in inositol metabolism
IT893_14865	COG3962	Belongs to the TPP enzyme family
IT893_14870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT893_14875	COG1129	ABC transporter
IT893_14880	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT893_14890	COG0673	inositol 2-dehydrogenase activity
IT893_14915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT893_14950	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT893_14955	COG1129	ABC transporter
IT893_14960	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT893_14965	COG1129	ABC transporter
IT893_14970	COG1879	ABC-type sugar transport system periplasmic component
IT893_14990	COG1609	Transcriptional regulator
IT893_15010	COG4774	siderophore transport
IT893_15015	COG1120	ATPase activity
IT893_15020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IT893_15030	COG4114	ferric iron reductase
IT893_15045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IT893_15060	COG0626	cystathionine gamma-synthase activity
IT893_15130	COG0826	peptidase U32
IT893_15135	COG0826	peptidase U32
IT893_15140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT893_15150	COG2223	nitrite transmembrane transporter activity
IT893_15155	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IT893_15160	COG1140	nitrate reductase beta subunit
IT893_15165	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IT893_15170	COG2181	nitrate reductase activity
IT893_15175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT893_15180	COG0288	reversible hydration of carbon dioxide
IT893_15185	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IT893_15185	COG1618	nucleotide phosphatase activity, acting on free nucleotides
IT893_15195	COG0531	amino acid
IT893_15290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IT893_15295	COG0358	DNA primase activity
IT893_15300	COG1610	YqeY-like protein
IT893_15305	COG0505	Belongs to the CarA family
IT893_15315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT893_15330	COG1522	sequence-specific DNA binding
IT893_15335	COG0492	ferredoxin-NADP+ reductase activity
IT893_15340	COG0583	DNA-binding transcription factor activity
IT893_15345	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IT893_15350	COG0783	Belongs to the Dps family
IT893_15355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT893_15375	COG0154	amidase activity
IT893_15390	COG0556	nucleotide-excision repair
IT893_15395	COG0436	Aminotransferase
IT893_15405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT893_15410	COG0450	alkyl hydroperoxide reductase
IT893_15415	COG0583	DNA-binding transcription factor activity
IT893_15430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IT893_15430	COG1618	nucleotide phosphatase activity, acting on free nucleotides
IT893_15435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT893_15435	COG0519	Catalyzes the synthesis of GMP from XMP
IT893_15440	COG0012	GTP binding
IT893_15450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IT893_15455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IT893_15480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT893_15510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT893_15540	COG0745	RESPONSE REGULATOR receiver
IT893_15545	COG1846	Transcriptional regulator
IT893_15550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT893_15560	COG0693	protein deglycase activity
IT893_15570	COG3119	arylsulfatase activity
IT893_15575	COG0583	DNA-binding transcription factor activity
IT893_15580	COG0010	Belongs to the arginase family
IT893_15590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IT893_15620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT893_15645	COG1072	(Pantothenic acid kinase))
IT893_15665	COG2132	Multicopper oxidase
IT893_15675	COG1522	sequence-specific DNA binding
IT893_15705	COG0482	sulfurtransferase activity
IT893_15720	COG0367	asparagine synthase
IT893_15765	COG2226	methyltransferase
IT893_15775	COG1132	(ABC) transporter
IT893_15785	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_15795	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_15800	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IT893_15805	COG0673	inositol 2-dehydrogenase activity
IT893_15815	COG0107	imidazoleglycerol-phosphate synthase activity
IT893_15820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IT893_15825	COG2089	acid synthase
IT893_15830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IT893_15835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IT893_15840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT893_15850	COG3243	poly(R)-hydroxyalkanoic acid synthase
IT893_15875	COG1396	sequence-specific DNA binding
IT893_15885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IT893_15890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IT893_15895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IT893_15915	COG1321	iron dependent repressor
IT893_15920	COG0803	Belongs to the bacterial solute-binding protein 9 family
IT893_15925	COG1121	(ABC) transporter
IT893_15930	COG1321	iron dependent repressor
IT893_15930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT893_15935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT893_15940	COG2375	cellular response to nickel ion
IT893_15950	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IT893_15955	COG1360	Flagellar Motor Protein
IT893_15970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IT893_15975	COG0612	Peptidase, M16
IT893_15980	COG0612	Peptidase, M16
IT893_15990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IT893_16000	COG0196	riboflavin kinase activity
IT893_16005	COG2030	dehydratase
IT893_16010	COG2226	methyltransferase
IT893_16020	COG4942	peptidase
IT893_16025	COG3300	MHYT domain
IT893_16025	COG5001	Diguanylate cyclase
IT893_16070	COG2207	Transcriptional regulator
IT893_16085	COG2207	Transcriptional regulator
IT893_16095	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IT893_16110	COG1177	transmembrane transport
IT893_16120	COG3842	ATPase activity
IT893_16125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT893_16130	COG1960	acyl-CoA dehydrogenase activity
IT893_16135	COG0583	DNA-binding transcription factor activity
IT893_16150	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IT893_16215	COG4251	negative regulation of phosphorylation
IT893_16225	COG2832	Protein of unknown function (DUF454)
IT893_16240	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IT893_16245	COG1320	monovalent cation:proton antiporter activity
IT893_16250	COG2212	antiporter activity
IT893_16255	COG1863	multisubunit Na H antiporter MnhE subunit
IT893_16260	COG0651	ATP synthesis coupled electron transport
IT893_16265	COG1006	Multisubunit Na H antiporter MnhC subunit
IT893_16270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT893_16270	COG2111	Na H antiporter
IT893_16280	COG0701	Predicted permease
IT893_16325	COG3300	MHYT domain
IT893_16325	COG5001	Diguanylate cyclase
IT893_16330	COG0733	neurotransmitter:sodium symporter activity
IT893_16345	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT893_16350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT893_16360	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IT893_16365	COG1138	Cytochrome C-type biogenesis protein
IT893_16370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT893_16375	COG3088	subunit of a heme lyase
IT893_16390	COG0741	lytic transglycosylase activity
IT893_16395	COG1573	uracil-dna glycosylase
IT893_16405	COG1012	belongs to the aldehyde dehydrogenase family
IT893_16415	COG0583	DNA-binding transcription factor activity
IT893_16430	COG1473	amidohydrolase
IT893_16460	COG0612	Peptidase, M16
IT893_16470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT893_16475	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IT893_16495	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IT893_16505	COG0109	protoheme IX farnesyltransferase activity
IT893_16510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT893_16515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IT893_16525	COG1678	Uncharacterized ACR, COG1678
IT893_16535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IT893_16535	COG0678	peroxiredoxin activity
IT893_16550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IT893_16555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IT893_16560	COG0509	glycine decarboxylation via glycine cleavage system
IT893_16565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT893_16575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IT893_16580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IT893_16585	COG0328	RNA-DNA hybrid ribonuclease activity
IT893_16595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT893_16595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT893_16600	COG0604	alcohol dehydrogenase
IT893_16620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IT893_16625	COG0625	glutathione transferase activity
IT893_16630	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IT893_16635	COG1116	anion transmembrane transporter activity
IT893_16640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT893_16645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT893_16650	COG3604	Transcriptional regulator
IT893_16660	COG2096	Adenosyltransferase
IT893_16675	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT893_16680	COG1070	Carbohydrate kinase
IT893_16685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT893_16690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT893_16695	COG0165	Argininosuccinate lyase
IT893_16705	COG0019	diaminopimelate decarboxylase activity
IT893_16720	COG2884	Cell division ATP-binding protein ftsE
IT893_16735	COG0204	Acyl-transferase
IT893_16740	COG0583	DNA-binding transcription factor activity
IT893_16760	COG0697	spore germination
IT893_16765	COG0287	Prephenate dehydrogenase
IT893_16780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT893_16785	COG2813	Specifically methylates the guanine in position
IT893_16785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT893_16800	COG0314	molybdopterin synthase activity
IT893_16805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IT893_16810	COG2233	PERMEase
IT893_16820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IT893_16825	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_16840	COG0745	RESPONSE REGULATOR receiver
IT893_16855	COG0581	inorganic phosphate transmembrane transporter activity
IT893_16860	COG0573	inorganic phosphate transmembrane transporter activity
IT893_16865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IT893_16875	COG0247	lactate metabolic process
IT893_16880	COG0277	FAD linked oxidase domain protein
IT893_16885	COG0277	FAD linked oxidase domain protein
IT893_16890	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IT893_16930	COG0747	negative chemotaxis
IT893_16960	COG1968	undecaprenyl-diphosphatase activity
IT893_16995	COG0778	Nitroreductase
IT893_17010	COG1058	Belongs to the CinA family
IT893_17010	COG1546	Belongs to the CinA family
IT893_17050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT893_17055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IT893_17075	COG4753	response regulator
IT893_17075	COG2207	Transcriptional regulator
IT893_17080	COG2204	response regulator
IT893_17085	COG0745	RESPONSE REGULATOR receiver
IT893_17085	COG2205	protein histidine kinase activity
IT893_17085	COG4191	Histidine kinase
IT893_17105	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_17110	COG1522	sequence-specific DNA binding
IT893_17115	COG3186	Phenylalanine-4-hydroxylase
IT893_17135	COG1703	isobutyryl-CoA mutase activity
IT893_17380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT893_17390	COG0501	Belongs to the peptidase M48B family
IT893_17400	COG2095	MarC family integral membrane protein
IT893_17415	COG0617	tRNA 3'-terminal CCA addition
IT893_17415	COG0517	IMP dehydrogenase activity
IT893_17415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IT893_17440	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_17450	COG0583	DNA-binding transcription factor activity
IT893_17455	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IT893_17465	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IT893_17470	COG1122	ATPase activity
IT893_17475	COG1268	BioY protein
IT893_17480	COG0640	Transcriptional regulator
IT893_17490	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IT893_17495	COG0830	nickel cation binding
IT893_17500	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IT893_17505	COG0804	urea catabolic process
IT893_17510	COG0832	Belongs to the urease beta subunit family
IT893_17515	COG0831	urea catabolic process
IT893_17520	COG0829	nickel cation binding
IT893_17530	COG0411	ABC transporter
IT893_17565	COG0583	DNA-binding transcription factor activity
IT893_17605	COG3845	ABC transporter
IT893_17610	COG0590	tRNA wobble adenosine to inosine editing
IT893_17620	COG2010	Cytochrome c
IT893_17620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT893_17645	COG4266	Belongs to the allantoicase family
IT893_17655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT893_17665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IT893_17685	COG2030	dehydratase
IT893_17690	COG2301	Belongs to the HpcH HpaI aldolase family
IT893_17725	COG1842	Phage shock protein A
IT893_17730	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IT893_17740	COG1960	acyl-CoA dehydrogenase activity
IT893_17745	COG0288	reversible hydration of carbon dioxide
IT893_17760	COG0183	Belongs to the thiolase family
IT893_17765	COG1960	acyl-CoA dehydrogenase activity
IT893_17780	COG0513	Belongs to the DEAD box helicase family
IT893_17790	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_17795	COG0583	DNA-binding transcription factor activity
IT893_17805	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IT893_17810	COG3474	cytochrome
IT893_17830	COG1280	lysine exporter protein (LysE YggA)
IT893_17845	COG3263	regulation of cellular component size
IT893_17850	COG1522	sequence-specific DNA binding
IT893_17855	COG0697	spore germination
IT893_17860	COG0697	spore germination
IT893_17865	COG0697	spore germination
IT893_17885	COG2154	pterin-4-alpha-carbinolamine dehydratase
IT893_17890	COG1573	uracil-dna glycosylase
IT893_17900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT893_17920	COG4172	Belongs to the ABC transporter superfamily
IT893_17925	COG4239	(ABC) transporter, permease
IT893_17930	COG4174	ABC transporter (Permease)
IT893_17935	COG4166	transmembrane transport
IT893_17940	COG0583	DNA-binding transcription factor activity
IT893_17975	COG1846	Transcriptional regulator
IT893_17980	COG0697	spore germination
IT893_18005	COG1741	Belongs to the pirin family
IT893_18010	COG0667	Aldo Keto reductase
IT893_18030	COG4181	ATPase activity
IT893_18035	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IT893_18040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT893_18050	COG0670	Belongs to the BI1 family
IT893_18060	COG0501	Belongs to the peptidase M48B family
IT893_18070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT893_18080	COG2902	Dehydrogenase
IT893_18085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IT893_18110	COG3118	belongs to the thioredoxin family
IT893_18120	COG2835	tetraacyldisaccharide 4'-kinase activity
IT893_18130	COG3047	cAMP biosynthetic process
IT893_18135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT893_18145	COG0004	ammonium transporteR
IT893_18150	COG0004	ammonium transporteR
IT893_18160	COG1674	ftsk spoiiie
IT893_18170	COG1074	ATP-dependent DNA helicase activity
IT893_18175	COG2887	Belongs to the helicase family. UvrD subfamily
IT893_18180	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IT893_18190	COG0802	atpase or kinase
IT893_18210	COG4702	Belongs to the UPF0303 family
IT893_18220	COG4251	negative regulation of phosphorylation
IT893_18230	COG0072	phenylalanine-tRNA ligase activity
IT893_18235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IT893_18240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IT893_18245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IT893_18250	COG0679	Auxin Efflux Carrier
IT893_18255	COG0745	RESPONSE REGULATOR receiver
IT893_18260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IT893_18270	COG0438	transferase activity, transferring glycosyl groups
IT893_18290	COG2350	Protein conserved in bacteria
IT893_18295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IT893_18305	COG0181	hydroxymethylbilane synthase activity
IT893_18325	COG0138	bifunctional purine biosynthesis protein purh
IT893_18330	COG5383	Protein conserved in bacteria
IT893_18340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IT893_18345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IT893_18345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IT893_18350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IT893_18355	COG5508	conserved small protein
IT893_18365	COG2183	response to ionizing radiation
IT893_18375	COG0352	thiamine-phosphate diphosphorylase activity
IT893_18385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IT893_18390	COG1012	belongs to the aldehyde dehydrogenase family
IT893_18405	COG0583	DNA-binding transcription factor activity
IT893_18410	COG2807	transmembrane transport
IT893_18420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IT893_18430	COG4520	surface antigen
IT893_18445	COG2067	long-chain fatty acid transport protein
IT893_18450	COG0318	PFAM AMP-dependent synthetase and ligase
IT893_18460	COG0183	Belongs to the thiolase family
IT893_18465	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT893_18465	COG1024	Enoyl-CoA hydratase
IT893_18470	COG1960	acyl-CoA dehydrogenase activity
IT893_18480	COG1024	Enoyl-CoA hydratase
IT893_18485	COG0300	oxidoreductase activity
IT893_18495	COG3416	Protein conserved in bacteria
IT893_18495	COG2943	transferase activity, transferring hexosyl groups
IT893_18535	COG0730	response to heat
IT893_18540	COG2186	Transcriptional regulator
IT893_18550	COG4208	sulfate ABC transporter
IT893_18565	COG3842	ATPase activity
IT893_18595	COG0583	DNA-binding transcription factor activity
IT893_18600	COG1741	Belongs to the pirin family
IT893_18610	COG4566	intracellular signal transduction
IT893_18620	COG2205	protein histidine kinase activity
IT893_18620	COG4191	Histidine kinase
IT893_18620	COG0745	RESPONSE REGULATOR receiver
IT893_18630	COG5001	Diguanylate cyclase
IT893_18630	COG4251	negative regulation of phosphorylation
IT893_18630	COG3706	GGDEF domain
IT893_18630	COG2203	Gaf domain
IT893_18640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IT893_18655	COG0028	Belongs to the TPP enzyme family
IT893_18660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IT893_18680	COG2267	carboxylic ester hydrolase activity
IT893_18690	COG1131	(ABC) transporter
IT893_18700	COG0133	tryptophan synthase activity
IT893_18710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IT893_18715	COG0285	dihydrofolate synthase activity
IT893_18730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT893_18730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT893_18735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IT893_18745	COG0443	Heat shock 70 kDa protein
IT893_18755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IT893_18765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IT893_18770	COG0792	nuclease activity
IT893_18795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT893_18800	COG1217	gtp-binding protein TYPA
IT893_18805	COG2211	Major facilitator Superfamily
IT893_18810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT893_18815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IT893_18820	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IT893_18825	COG1137	ATPase activity
IT893_18860	COG1403	HNH endonuclease
IT893_18870	COG0328	RNA-DNA hybrid ribonuclease activity
IT893_18905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IT893_18910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IT893_18915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IT893_18920	COG1420	regulation of RNA biosynthetic process
IT893_18925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IT893_18970	COG1216	Glycosyl transferase, family 2
IT893_18975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IT893_18980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IT893_18995	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IT893_19000	COG2992	FlgJ-related protein
IT893_19015	COG0280	phosphate acetyltransferase
IT893_19015	COG0281	malic enzyme
IT893_19025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IT893_19040	COG0180	Tryptophanyl-tRNA synthetase
IT893_19055	COG0745	RESPONSE REGULATOR receiver
IT893_19065	COG0352	thiamine-phosphate diphosphorylase activity
IT893_19065	COG0351	phosphomethylpyrimidine kinase
IT893_19120	COG0445	tRNA wobble uridine modification
IT893_19125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IT893_19130	COG3411	Ferredoxin
IT893_19140	COG1331	Highly conserved protein containing a thioredoxin domain
IT893_19170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT893_19180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IT893_19205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IT893_19215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IT893_19220	COG0424	maF-like protein
IT893_19225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IT893_19240	COG1981	membrane
IT893_19245	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IT893_19250	COG3030	protein affecting phage T7 exclusion by the F plasmid
IT893_19315	COG0625	glutathione transferase activity
IT893_19330	COG1846	Transcriptional regulator
IT893_19350	COG0606	chelatase, subunit chli
IT893_19360	COG0583	DNA-binding transcription factor activity
IT893_19370	COG0667	Aldo Keto reductase
IT893_19395	COG1028	Short-chain dehydrogenase reductase Sdr
IT893_19400	COG0583	DNA-binding transcription factor activity
IT893_19410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT893_19445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IT893_19455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IT893_19470	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IT893_19475	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IT893_19485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IT893_19490	COG5002	protein histidine kinase activity
IT893_19505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IT893_19510	COG0756	dUTP diphosphatase activity
IT893_19515	COG1959	2 iron, 2 sulfur cluster binding
IT893_19525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IT893_19535	COG1280	lysine exporter protein (LysE YggA)
IT893_19545	COG1285	pathogenesis
IT893_19550	COG1609	Transcriptional regulator
IT893_19555	COG2723	6-phospho-beta-galactosidase activity
IT893_19560	COG1653	transport
IT893_19565	COG1175	transmembrane transport
IT893_19570	COG0395	ABC-type sugar transport system, permease component
IT893_19580	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IT893_19585	COG1214	PFAM Peptidase M22, glycoprotease
IT893_19615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IT893_19620	COG1702	phosphate starvation-inducible protein PhoH
IT893_19630	COG1253	flavin adenine dinucleotide binding
IT893_19635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IT893_19640	COG1396	sequence-specific DNA binding
IT893_19645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IT893_19650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IT893_19665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IT893_19675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IT893_19680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IT893_19685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IT893_19690	COG1185	polyribonucleotide nucleotidyltransferase activity
IT893_19705	COG1592	Rubrerythrin
IT893_19715	COG4302	ethanolamine ammonia-lyase activity
IT893_19720	COG4303	Ethanolamine ammonia lyase large subunit
IT893_19725	COG1120	ATPase activity
IT893_19730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT893_19775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IT893_19785	COG1305	Transglutaminase-like
IT893_19795	COG2308	Evidence 4 Homologs of previously reported genes of
IT893_19825	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IT893_19830	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IT893_19850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT893_19860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IT893_19865	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IT893_19910	COG1492	cobalamin metabolic process
IT893_19940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT893_19950	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IT893_19965	COG1999	signal sequence binding
IT893_19970	COG1797	cobyrinic acid a,c-diamide synthase activity
IT893_19975	COG2983	Belongs to the UPF0260 family
IT893_19985	COG1234	tRNA 3'-trailer cleavage
IT893_20010	COG0519	Catalyzes the synthesis of GMP from XMP
IT893_20010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT893_20025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT893_20055	COG0539	negative regulation of cytoplasmic translation
IT893_20060	COG0616	signal peptide processing
IT893_20065	COG0776	regulation of translation
IT893_20080	COG2814	Major facilitator Superfamily
IT893_20085	COG0730	response to heat
IT893_20090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IT893_20095	COG1024	Enoyl-CoA hydratase
IT893_20100	COG0268	Binds directly to 16S ribosomal RNA