locus-tag	class	description
IT971_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IT971_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IT971_00025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IT971_00030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IT971_00060	COG1280	lysine exporter protein (LysE YggA)
IT971_00070	COG0137	argininosuccinate synthase activity
IT971_00075	COG0101	tRNA pseudouridine synthase activity
IT971_00085	COG1346	cytolysis
IT971_00095	COG1393	Belongs to the ArsC family
IT971_00105	COG2137	regulation of response to DNA damage stimulus
IT971_00110	COG0842	Transport permease protein
IT971_00115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IT971_00120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IT971_00125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IT971_00160	COG1595	DNA-templated transcription, initiation
IT971_00170	COG0589	response to stress
IT971_00175	COG0659	secondary active sulfate transmembrane transporter activity
IT971_00180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT971_00185	COG1322	Protein conserved in bacteria
IT971_00190	COG0242	peptide deformylase activity
IT971_00210	COG0583	DNA-binding transcription factor activity
IT971_00235	COG2358	TRAP transporter, solute receptor (TAXI family
IT971_00240	COG2204	response regulator
IT971_00245	COG4191	Histidine kinase
IT971_00250	COG0745	RESPONSE REGULATOR receiver
IT971_00265	COG1660	Displays ATPase and GTPase activities
IT971_00270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT971_00270	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT971_00280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT971_00285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IT971_00310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IT971_00320	COG1078	dGTPase activity
IT971_00325	COG2205	protein histidine kinase activity
IT971_00355	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IT971_00370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_00390	COG1802	Transcriptional regulator
IT971_00400	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IT971_00410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IT971_00415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IT971_00420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IT971_00430	COG2816	NAD+ diphosphatase activity
IT971_00445	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
IT971_00450	COG0583	DNA-binding transcription factor activity
IT971_00460	COG0625	glutathione transferase activity
IT971_00470	COG3128	pkhd-type hydroxylase
IT971_00475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT971_00480	COG2171	N-acyltransferase activity
IT971_00490	COG2200	EAL domain
IT971_00490	COG2199	diguanylate cyclase activity
IT971_00495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IT971_00510	COG3237	CsbD-like
IT971_00520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IT971_00520	COG0512	Glutamine amidotransferase of anthranilate synthase
IT971_00525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT971_00540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IT971_00560	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IT971_00580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IT971_00590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IT971_00605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IT971_00620	COG2818	Glycosylase
IT971_00625	COG5002	protein histidine kinase activity
IT971_00635	COG0398	Pfam SNARE associated Golgi protein
IT971_00650	COG0302	gtp cyclohydrolase
IT971_00660	COG3001	Fructosamine kinase
IT971_00665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IT971_00680	COG0534	Mate efflux family protein
IT971_00685	COG0584	glycerophosphoryl diester phosphodiesterase
IT971_00740	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IT971_00745	COG0039	L-malate dehydrogenase activity
IT971_00750	COG0657	acetylesterase activity
IT971_00760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT971_00770	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IT971_00775	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IT971_00780	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IT971_00785	COG3639	organic phosphonate transmembrane transporter activity
IT971_00795	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IT971_00800	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IT971_00800	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IT971_00805	COG3454	Phosphonate metabolism
IT971_00810	COG4778	phosphonate C-P lyase system protein PhnL
IT971_00815	COG4107	phosphonate C-P lyase system protein PhnK
IT971_00820	COG3627	carbon phosphorus lyase activity
IT971_00835	COG3624	Phosphonate C-P lyase system protein PhnG
IT971_00840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT971_00850	COG5001	Diguanylate cyclase
IT971_00855	COG0024	Methionine aminopeptidase
IT971_00860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IT971_00875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_00890	COG2081	HI0933 family
IT971_00895	COG3706	GGDEF domain
IT971_00920	COG1187	pseudouridine synthase activity
IT971_00925	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IT971_00930	COG3806	Anti-sigma factor
IT971_00935	COG1595	DNA-templated transcription, initiation
IT971_00950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT971_00955	COG2211	Major facilitator Superfamily
IT971_00955	COG2190	(PTS) system
IT971_00970	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_00985	COG0564	pseudouridine synthase activity
IT971_00995	COG1803	Methylglyoxal synthase
IT971_01030	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT971_01040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IT971_01045	COG0045	succinate-CoA ligase (ADP-forming) activity
IT971_01050	COG0039	L-malate dehydrogenase activity
IT971_01055	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IT971_01070	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT971_01075	COG1129	ABC transporter
IT971_01080	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT971_01085	COG0673	inositol 2-dehydrogenase activity
IT971_01090	COG1082	Xylose isomerase domain protein TIM barrel
IT971_01100	COG1196	nuclear chromosome segregation
IT971_01100	COG3264	Mechanosensitive ion channel
IT971_01105	COG0494	nUDIX hydrolase
IT971_01115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IT971_01130	COG0174	glutamine synthetase
IT971_01140	COG0625	glutathione transferase activity
IT971_01150	COG4974	Belongs to the 'phage' integrase family
IT971_01160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT971_01185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IT971_01210	COG0784	Response regulator, receiver
IT971_01215	COG4235	cytochrome complex assembly
IT971_01220	COG1138	Cytochrome C-type biogenesis protein
IT971_01225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IT971_01230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IT971_01235	COG1702	phosphate starvation-inducible protein PhoH
IT971_01245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IT971_01305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT971_01310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT971_01330	COG0519	Catalyzes the synthesis of GMP from XMP
IT971_01345	COG1872	DUF167
IT971_01350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IT971_01355	COG3273	potassium ion transport
IT971_01355	COG0471	metal ion transport
IT971_01360	COG3214	Protein conserved in bacteria
IT971_01365	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_01375	COG0395	ABC-type sugar transport system, permease component
IT971_01395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IT971_01400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT971_01415	COG1595	DNA-templated transcription, initiation
IT971_01430	COG0066	3-isopropylmalate dehydratase activity
IT971_01440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IT971_01455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IT971_01460	COG0228	four-way junction DNA binding
IT971_01465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IT971_01480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT971_01490	COG2217	Heavy metal translocating P-type atpase
IT971_01505	COG2010	Cytochrome c
IT971_01530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IT971_01535	COG0126	phosphoglycerate kinase activity
IT971_01555	COG2267	carboxylic ester hydrolase activity
IT971_01560	COG4106	trans-aconitate 2-methyltransferase activity
IT971_01570	COG1051	belongs to the nudix hydrolase family
IT971_01580	COG0793	Belongs to the peptidase S41A family
IT971_01585	COG4942	peptidase
IT971_01590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IT971_01595	COG1760	l-serine dehydratase
IT971_01600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IT971_01615	COG0799	negative regulation of ribosome biogenesis
IT971_01620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IT971_01630	COG5265	(ABC) transporter
IT971_01650	COG3706	GGDEF domain
IT971_01670	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IT971_01680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IT971_01685	COG0402	S-adenosylhomocysteine deaminase activity
IT971_01695	COG4603	Belongs to the binding-protein-dependent transport system permease family
IT971_01700	COG3845	ABC transporter
IT971_01705	COG1744	ABC transporter substrate-binding protein PnrA-like
IT971_01720	COG1194	a g-specific adenine glycosylase
IT971_01730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IT971_01730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IT971_01735	COG1196	nuclear chromosome segregation
IT971_01770	COG0435	Glutathione S-transferase
IT971_01775	COG0583	DNA-binding transcription factor activity
IT971_01795	COG0714	Associated with various cellular activities
IT971_01815	COG0617	tRNA 3'-terminal CCA addition
IT971_01830	COG2202	Pas domain
IT971_01830	COG2200	EAL domain
IT971_01830	COG2199	diguanylate cyclase activity
IT971_01835	COG4974	Belongs to the 'phage' integrase family
IT971_01850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IT971_01855	COG4536	flavin adenine dinucleotide binding
IT971_01860	COG0517	IMP dehydrogenase activity
IT971_01885	COG0271	Belongs to the BolA IbaG family
IT971_01905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT971_01930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IT971_01940	COG4774	siderophore transport
IT971_01950	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IT971_01955	COG1238	metal cluster binding
IT971_01970	COG1454	alcohol dehydrogenase
IT971_01975	COG1012	belongs to the aldehyde dehydrogenase family
IT971_01980	COG1454	alcohol dehydrogenase
IT971_01990	COG1129	ABC transporter
IT971_02015	COG2204	response regulator
IT971_02025	COG1063	alcohol dehydrogenase
IT971_02040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_02045	COG1802	Transcriptional regulator
IT971_02050	COG1312	Catalyzes the dehydration of D-mannonate
IT971_02055	COG0246	Mannitol dehydrogenase
IT971_02075	COG2814	Major facilitator Superfamily
IT971_02085	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IT971_02095	COG3842	ATPase activity
IT971_02115	COG1609	Transcriptional regulator
IT971_02120	COG2205	protein histidine kinase activity
IT971_02125	COG0745	RESPONSE REGULATOR receiver
IT971_02150	COG1522	sequence-specific DNA binding
IT971_02175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_02190	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IT971_02200	COG0625	glutathione transferase activity
IT971_02220	COG0019	diaminopimelate decarboxylase activity
IT971_02230	COG1309	transcriptional regulator
IT971_02240	COG1609	Transcriptional regulator
IT971_02245	COG1129	ABC transporter
IT971_02250	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT971_02255	COG1879	ABC-type sugar transport system periplasmic component
IT971_02265	COG0673	inositol 2-dehydrogenase activity
IT971_02275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT971_02290	COG0154	amidase activity
IT971_02325	COG1522	sequence-specific DNA binding
IT971_02330	COG3608	succinylglutamate desuccinylase aspartoacylase
IT971_02335	COG0006	proline dipeptidase activity
IT971_02340	COG2423	ornithine cyclodeaminase activity
IT971_02345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT971_02355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_02360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT971_02365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT971_02370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_02375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT971_02380	COG1012	belongs to the aldehyde dehydrogenase family
IT971_02395	COG1234	tRNA 3'-trailer cleavage
IT971_02415	COG1733	regulation of RNA biosynthetic process
IT971_02445	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IT971_02475	COG3706	GGDEF domain
IT971_02480	COG0321	lipoyl(octanoyl) transferase activity
IT971_02490	COG0281	malic enzyme
IT971_02490	COG0280	phosphate acetyltransferase
IT971_02495	COG2239	Acts as a magnesium transporter
IT971_02525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IT971_02565	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_02595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IT971_02605	COG2274	protein secretion by the type I secretion system
IT971_02610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT971_02620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IT971_02630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IT971_02635	COG0706	membrane insertase activity
IT971_02640	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IT971_02645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IT971_02650	COG3706	GGDEF domain
IT971_02655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IT971_02660	COG0552	protein localization to endoplasmic reticulum
IT971_02670	COG0783	Belongs to the Dps family
IT971_02700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IT971_02725	COG0742	ribosomal rna small subunit methyltransferase
IT971_02730	COG1187	pseudouridine synthase activity
IT971_02735	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IT971_02740	COG0590	tRNA wobble adenosine to inosine editing
IT971_02745	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IT971_02750	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IT971_02760	COG4221	oxidoreductase activity
IT971_02765	COG2207	Transcriptional regulator
IT971_02775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT971_02780	COG1120	ATPase activity
IT971_02785	COG0151	Belongs to the GarS family
IT971_02790	COG1570	exodeoxyribonuclease VII activity
IT971_02800	COG0405	Gamma-glutamyltransferase
IT971_02820	COG1663	tetraacyldisaccharide 4'-kinase activity
IT971_02825	COG1519	Transferase
IT971_02835	COG1132	(ABC) transporter
IT971_02845	COG0438	transferase activity, transferring glycosyl groups
IT971_02855	COG1597	lipid kinase activity
IT971_02860	COG0312	modulator of DNA gyrase
IT971_02880	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IT971_02895	COG2264	protein methyltransferase activity
IT971_02905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IT971_02935	COG3639	organic phosphonate transmembrane transporter activity
IT971_02950	COG1349	DNA-binding transcription factor activity
IT971_02980	COG1280	lysine exporter protein (LysE YggA)
IT971_02990	COG0604	alcohol dehydrogenase
IT971_03000	COG4608	Belongs to the ABC transporter superfamily
IT971_03005	COG0444	Belongs to the ABC transporter superfamily
IT971_03010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT971_03015	COG0601	transmembrane transport
IT971_03020	COG0747	negative chemotaxis
IT971_03050	COG0312	modulator of DNA gyrase
IT971_03065	COG1612	heme a metabolic process
IT971_03075	COG0175	sulfate reduction
IT971_03105	COG2373	Large extracellular alpha-helical protein
IT971_03110	COG4953	penicillin-binding protein 1C
IT971_03115	COG1522	sequence-specific DNA binding
IT971_03120	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IT971_03140	COG3265	gluconokinase activity
IT971_03145	COG1609	Transcriptional regulator
IT971_03150	COG1739	Uncharacterized protein family UPF0029
IT971_03170	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IT971_03185	COG0393	Putative heavy-metal-binding
IT971_03190	COG0393	Putative heavy-metal-binding
IT971_03200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT971_03215	COG0789	Transcriptional regulator
IT971_03245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT971_03255	COG0010	Belongs to the arginase family
IT971_03265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT971_03285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IT971_03295	COG0668	transmembrane transport
IT971_03300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IT971_03305	COG2962	Rard protein
IT971_03350	COG0784	Response regulator, receiver
IT971_03350	COG2198	Histidine kinase
IT971_03350	COG0643	Histidine kinase
IT971_03375	COG0745	RESPONSE REGULATOR receiver
IT971_03395	COG0861	Integral membrane protein TerC family
IT971_03400	COG4134	Bacterial extracellular solute-binding protein
IT971_03405	COG4135	transport system, permease component
IT971_03410	COG4136	ATPase activity
IT971_03415	COG3128	pkhd-type hydroxylase
IT971_03440	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IT971_03445	COG2204	response regulator
IT971_03450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IT971_03455	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IT971_03465	COG1766	The M ring may be actively involved in energy transduction
IT971_03470	COG1749	Flagellar hook protein flgE
IT971_03485	COG1516	flagellar protein fliS
IT971_03520	COG1256	bacterial-type flagellum assembly
IT971_03520	COG4786	Flagellar basal body rod
IT971_03530	COG3951	Flagellar rod assembly protein muramidase FlgJ
IT971_03535	COG1706	bacterial-type flagellum-dependent cell motility
IT971_03550	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IT971_03560	COG4786	Flagellar basal body rod
IT971_03565	COG4786	Flagellar basal body rod
IT971_03590	COG0745	RESPONSE REGULATOR receiver
IT971_03620	COG1338	Plays a role in the flagellum-specific transport system
IT971_03635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IT971_03645	COG1815	bacterial-type flagellum-dependent cell motility
IT971_03650	COG1558	bacterial-type flagellum-dependent cell motility
IT971_03655	COG1677	Flagellar hook-basal body complex protein FliE
IT971_03660	COG1987	bacterial-type flagellum assembly
IT971_03665	COG1684	flagellar biosynthetic protein fliR
IT971_03670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IT971_03740	COG5487	UPF0391 membrane protein
IT971_03790	COG0542	response to heat
IT971_03800	COG3011	Protein conserved in bacteria
IT971_03810	COG4187	Peptidase family M20/M25/M40
IT971_03815	COG0584	glycerophosphoryl diester phosphodiesterase
IT971_03820	COG0655	NAD(P)H dehydrogenase (quinone) activity
IT971_03830	COG0538	isocitrate dehydrogenase activity
IT971_03865	COG0395	ABC-type sugar transport system, permease component
IT971_03875	COG1653	transport
IT971_03880	COG3842	ATPase activity
IT971_03885	COG1349	DNA-binding transcription factor activity
IT971_03890	COG0492	ferredoxin-NADP+ reductase activity
IT971_03925	COG0688	phosphatidylethanolamine metabolic process
IT971_03985	COG0602	queuosine metabolic process
IT971_03990	COG0720	synthase
IT971_03995	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IT971_04000	COG2226	methyltransferase
IT971_04020	COG2032	superoxide dismutase activity
IT971_04035	COG0495	leucyl-tRNA aminoacylation
IT971_04060	COG0438	transferase activity, transferring glycosyl groups
IT971_04095	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IT971_04130	COG1643	Atp-dependent helicase
IT971_04185	COG2084	Dehydrogenase
IT971_04220	COG3247	response to pH
IT971_04225	COG1819	glycosyl
IT971_04230	COG1199	ATP-dependent helicase activity
IT971_04250	COG1238	metal cluster binding
IT971_04260	COG1764	response to oxidative stress
IT971_04270	COG1846	Transcriptional regulator
IT971_04300	COG4191	Histidine kinase
IT971_04310	COG0506	proline dehydrogenase activity
IT971_04320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT971_04325	COG1609	Transcriptional regulator
IT971_04330	COG1840	ABC-type Fe3 transport system, periplasmic component
IT971_04340	COG3842	ATPase activity
IT971_04345	COG0483	inositol monophosphate 1-phosphatase activity
IT971_04360	COG3422	double-strand break repair
IT971_04600	COG1595	DNA-templated transcription, initiation
IT971_04610	COG4774	siderophore transport
IT971_04615	COG2814	Major facilitator Superfamily
IT971_04625	COG0167	dihydroorotate dehydrogenase activity
IT971_04645	COG0697	spore germination
IT971_04660	COG4372	Transposase
IT971_04675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT971_04680	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IT971_04705	COG1595	DNA-templated transcription, initiation
IT971_04715	COG4774	siderophore transport
IT971_04725	COG0500	methyltransferase
IT971_04730	COG4120	Belongs to the binding-protein-dependent transport system permease family
IT971_04755	COG1309	transcriptional regulator
IT971_04760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT971_04765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT971_04790	COG2391	methyltransferase activity
IT971_04810	COG0513	Belongs to the DEAD box helicase family
IT971_04815	COG1278	Cold shock
IT971_04820	COG2186	Transcriptional regulator
IT971_04830	COG0765	amino acid transport
IT971_04835	COG0765	amino acid transport
IT971_04850	COG1671	Belongs to the UPF0178 family
IT971_04870	COG2130	NADP-dependent
IT971_04885	COG0523	cobalamin synthesis protein
IT971_04890	COG0625	glutathione transferase activity
IT971_04895	COG0625	glutathione transferase activity
IT971_04900	COG0477	Major facilitator Superfamily
IT971_04905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IT971_04910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT971_04915	COG1845	cytochrome c oxidase, subunit III
IT971_04920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IT971_04925	COG3346	SURF1 family
IT971_04935	COG2226	methyltransferase
IT971_04940	COG1309	transcriptional regulator
IT971_04945	COG1970	mechanosensitive ion channel activity
IT971_04955	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IT971_04975	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IT971_04975	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IT971_04985	COG3180	Ammonia monooxygenase
IT971_04990	COG1335	isochorismatase
IT971_05005	COG2378	regulation of single-species biofilm formation
IT971_05010	COG5001	Diguanylate cyclase
IT971_05010	COG3300	MHYT domain
IT971_05025	COG1366	Belongs to the anti-sigma-factor antagonist family
IT971_05030	COG2204	response regulator
IT971_05045	COG5002	protein histidine kinase activity
IT971_05045	COG0784	Response regulator, receiver
IT971_05060	COG0584	glycerophosphoryl diester phosphodiesterase
IT971_05065	COG1879	ABC-type sugar transport system periplasmic component
IT971_05075	COG0772	Belongs to the SEDS family
IT971_05080	COG0768	penicillin binding
IT971_05105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT971_05110	COG1280	lysine exporter protein (LysE YggA)
IT971_05125	COG3706	GGDEF domain
IT971_05130	COG1278	Cold shock
IT971_05135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IT971_05140	COG5285	phytanoyl-CoA dioxygenase
IT971_05160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IT971_05165	COG0840	transmembrane signaling receptor activity
IT971_05180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IT971_05180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IT971_05190	COG0519	Catalyzes the synthesis of GMP from XMP
IT971_05285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IT971_05290	COG0732	type I restriction modification DNA specificity domain
IT971_05315	COG2824	Alkylphosphonate utilization operon protein PhnA
IT971_05325	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_05330	COG3655	Transcriptional regulator
IT971_05350	COG0640	Transcriptional regulator
IT971_05380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT971_05385	COG0765	amino acid transport
IT971_05390	COG0765	amino acid transport
IT971_05440	COG1012	belongs to the aldehyde dehydrogenase family
IT971_05450	COG0596	Alpha beta hydrolase
IT971_05455	COG0494	nUDIX hydrolase
IT971_05480	COG1653	transport
IT971_05495	COG0366	Alpha amylase catalytic
IT971_05500	COG3842	ATPase activity
IT971_05505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IT971_05510	COG0363	glucosamine-6-phosphate deaminase activity
IT971_05515	COG0129	dihydroxy-acid dehydratase activity
IT971_05520	COG0837	glucose binding
IT971_05525	COG0800	Aldolase
IT971_05555	COG1595	DNA-templated transcription, initiation
IT971_05605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT971_05615	COG2719	SpoVR family
IT971_05620	COG2718	Belongs to the UPF0229 family
IT971_05625	COG2766	serine protein kinase
IT971_05630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IT971_05665	COG0251	oxidation-reduction process
IT971_05670	COG1309	transcriptional regulator
IT971_05690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT971_05705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IT971_05715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IT971_05725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IT971_05735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IT971_05740	COG0222	ribosome binding
IT971_05745	COG0085	RNA polymerase activity
IT971_05750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IT971_05765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IT971_05770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IT971_05780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IT971_05785	COG0088	Forms part of the polypeptide exit tunnel
IT971_05790	COG0089	rRNA binding
IT971_05800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IT971_05810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IT971_05815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IT971_05820	COG0255	Belongs to the universal ribosomal protein uL29 family
IT971_05830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IT971_05835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IT971_05840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IT971_05850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IT971_05855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IT971_05860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IT971_05870	COG1841	ribosomal large subunit assembly
IT971_05875	COG0200	Binds to the 23S rRNA
IT971_05880	COG0201	protein transport
IT971_05885	COG0563	adenylate kinase activity
IT971_05890	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IT971_05895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IT971_05905	COG0203	ribosomal protein L17
IT971_05910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT971_05925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IT971_05930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IT971_05940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT971_05945	COG0564	pseudouridine synthase activity
IT971_05955	COG0546	phosphoglycolate phosphatase activity
IT971_05970	COG0412	Dienelactone hydrolase
IT971_05975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT971_06000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT971_06010	COG4770	biotin carboxylase activity
IT971_06035	COG1254	Belongs to the acylphosphatase family
IT971_06050	COG0277	FAD linked oxidase domain protein
IT971_06055	COG0009	L-threonylcarbamoyladenylate synthase
IT971_06095	COG1355	regulation of microtubule-based process
IT971_06105	COG0456	acetyltransferase
IT971_06115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT971_06155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IT971_06160	COG2011	ABC-type metal ion transport system permease component
IT971_06185	COG0477	Major facilitator Superfamily
IT971_06215	COG0798	PFAM Bile acid sodium symporter
IT971_06225	COG0431	NADPH-dependent FMN reductase
IT971_06245	COG0488	(ABC) transporter
IT971_06250	COG0105	UTP biosynthetic process
IT971_06270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IT971_06275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IT971_06285	COG0628	permease
IT971_06290	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IT971_06295	COG0189	ligase activity
IT971_06295	COG4067	protein conserved in archaea
IT971_06300	COG0189	ligase activity
IT971_06310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IT971_06320	COG0702	epimerase
IT971_06325	COG0583	DNA-binding transcription factor activity
IT971_06340	COG0248	Ppx GppA phosphatase
IT971_06345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IT971_06370	COG0640	Transcriptional regulator
IT971_06375	COG0123	including yeast histone deacetylase and acetoin utilization protein
IT971_06385	COG0142	geranyltranstransferase activity
IT971_06395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IT971_06415	COG0318	PFAM AMP-dependent synthetase and ligase
IT971_06440	COG1802	Transcriptional regulator
IT971_06445	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IT971_06455	COG0583	DNA-binding transcription factor activity
IT971_06485	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IT971_06490	COG1295	ribonuclease BN
IT971_06500	COG0300	oxidoreductase activity
IT971_06505	COG0318	PFAM AMP-dependent synthetase and ligase
IT971_06515	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IT971_06515	COG3264	Mechanosensitive ion channel
IT971_06535	COG0484	heat shock protein binding
IT971_06540	COG4520	surface antigen
IT971_06550	COG0640	Transcriptional regulator
IT971_06565	COG2135	peptidase activity
IT971_06570	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_06575	COG3153	acetyltransferase
IT971_06585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT971_06590	COG0156	8-amino-7-oxononanoate synthase activity
IT971_06595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT971_06630	COG2249	NAD(P)H dehydrogenase (quinone) activity
IT971_06635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IT971_06645	COG0659	secondary active sulfate transmembrane transporter activity
IT971_06650	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT971_06650	COG1024	Enoyl-CoA hydratase
IT971_06660	COG2814	Major facilitator Superfamily
IT971_06665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_06670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT971_06685	COG4191	Histidine kinase
IT971_06695	COG0583	DNA-binding transcription factor activity
IT971_06700	COG2814	Major facilitator Superfamily
IT971_06710	COG0656	L-ascorbic acid biosynthetic process
IT971_06715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IT971_06725	COG1252	NADH dehydrogenase
IT971_06730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IT971_06735	COG0583	DNA-binding transcription factor activity
IT971_06740	COG3622	Belongs to the hyi family
IT971_06755	COG2186	Transcriptional regulator
IT971_06765	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IT971_06810	COG3135	benzoate transporter
IT971_06835	COG0483	inositol monophosphate 1-phosphatase activity
IT971_06840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IT971_06845	COG0352	thiamine-phosphate diphosphorylase activity
IT971_06870	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IT971_06880	COG1692	metallophosphoesterase
IT971_06895	COG0217	transcriptional regulatory protein
IT971_06905	COG0632	four-way junction helicase activity
IT971_06910	COG2255	four-way junction helicase activity
IT971_06915	COG0824	Thioesterase
IT971_06925	COG0848	biopolymer transport protein
IT971_06950	COG0037	tRNA processing
IT971_06955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IT971_06960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IT971_06980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IT971_06985	COG0352	thiamine-phosphate diphosphorylase activity
IT971_06985	COG0351	phosphomethylpyrimidine kinase
IT971_07000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IT971_07010	COG0129	dihydroxy-acid dehydratase activity
IT971_07020	COG0686	Belongs to the AlaDH PNT family
IT971_07025	COG1522	sequence-specific DNA binding
IT971_07045	COG1177	transmembrane transport
IT971_07050	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT971_07055	COG3842	ATPase activity
IT971_07065	COG0174	glutamine synthetase
IT971_07075	COG4948	Mandelate Racemase Muconate Lactonizing
IT971_07105	COG4095	Psort location CytoplasmicMembrane, score
IT971_07120	COG0765	amino acid transport
IT971_07125	COG1126	abc transporter atp-binding protein
IT971_07130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IT971_07140	COG0842	Transport permease protein
IT971_07145	COG1129	ABC transporter
IT971_07145	COG0842	Transport permease protein
IT971_07150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT971_07160	COG2199	diguanylate cyclase activity
IT971_07160	COG2200	EAL domain
IT971_07160	COG2202	Pas domain
IT971_07175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IT971_07180	COG0583	DNA-binding transcription factor activity
IT971_07195	COG0277	FAD linked oxidase domain protein
IT971_07195	COG0247	lactate metabolic process
IT971_07210	COG0583	DNA-binding transcription factor activity
IT971_07265	COG1840	ABC-type Fe3 transport system, periplasmic component
IT971_07280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IT971_07285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IT971_07290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT971_07295	COG2076	Multidrug Resistance protein
IT971_07335	COG2194	sulfuric ester hydrolase activity
IT971_07340	COG1309	transcriptional regulator
IT971_07345	COG0432	Pfam Uncharacterised protein family UPF0047
IT971_07380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IT971_07400	COG4765	Protein conserved in bacteria
IT971_07405	COG2353	YceI-like domain
IT971_07410	COG3038	cytochrome b561
IT971_07415	COG2353	YceI-like domain
IT971_07425	COG0400	carboxylic ester hydrolase activity
IT971_07430	COG0534	Mate efflux family protein
IT971_07435	COG1522	sequence-specific DNA binding
IT971_07445	COG1959	2 iron, 2 sulfur cluster binding
IT971_07450	COG0513	Belongs to the DEAD box helicase family
IT971_07475	COG3038	cytochrome b561
IT971_07480	COG2066	Belongs to the glutaminase family
IT971_07485	COG0187	DNA topoisomerase II activity
IT971_07490	COG1607	acyl-coa hydrolase
IT971_07505	COG4221	oxidoreductase activity
IT971_07520	COG4608	Belongs to the ABC transporter superfamily
IT971_07525	COG0444	Belongs to the ABC transporter superfamily
IT971_07530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT971_07535	COG0601	transmembrane transport
IT971_07540	COG0747	negative chemotaxis
IT971_07575	COG0469	pyruvate kinase activity
IT971_07595	COG0693	protein deglycase activity
IT971_07600	COG0668	transmembrane transport
IT971_07615	COG1832	CoA-binding protein
IT971_07655	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IT971_07660	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IT971_07680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IT971_07695	COG0028	Belongs to the TPP enzyme family
IT971_07710	COG2226	methyltransferase
IT971_07730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IT971_07735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT971_07740	COG0697	spore germination
IT971_07750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IT971_07760	COG1858	cytochrome C peroxidase
IT971_07765	COG2084	Dehydrogenase
IT971_07785	COG0436	Aminotransferase
IT971_07795	COG1494	fructose-1,6-bisphosphatase
IT971_07800	COG0443	Heat shock 70 kDa protein
IT971_07815	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IT971_07815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IT971_07830	COG2223	nitrite transmembrane transporter activity
IT971_07850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT971_07870	COG1234	tRNA 3'-trailer cleavage
IT971_07900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IT971_07925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT971_07935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT971_07940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT971_07945	COG1116	anion transmembrane transporter activity
IT971_07960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT971_07965	COG0372	Belongs to the citrate synthase family
IT971_07995	COG0123	including yeast histone deacetylase and acetoin utilization protein
IT971_08245	COG4228	DNA circulation
IT971_08310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IT971_08390	COG0523	cobalamin synthesis protein
IT971_08395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IT971_08410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT971_08415	COG0460	homoserine dehydrogenase
IT971_08430	COG0626	cystathionine gamma-synthase activity
IT971_08440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IT971_08455	COG2897	thiosulfate sulfurtransferase activity
IT971_08460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IT971_08500	COG1620	l-lactate permease
IT971_08505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT971_08515	COG0583	DNA-binding transcription factor activity
IT971_08520	COG2814	Major facilitator Superfamily
IT971_08530	COG0494	nUDIX hydrolase
IT971_08535	COG3706	GGDEF domain
IT971_08540	COG1247	-acetyltransferase
IT971_08545	COG2195	Cleaves the N-terminal amino acid of tripeptides
IT971_08550	COG0484	heat shock protein binding
IT971_08600	COG0730	response to heat
IT971_08605	COG0425	Belongs to the sulfur carrier protein TusA family
IT971_08610	COG2153	protein acetylation
IT971_08645	COG1067	ATP-dependent peptidase activity
IT971_08650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT971_08675	COG3273	potassium ion transport
IT971_08675	COG0471	metal ion transport
IT971_08710	COG0564	pseudouridine synthase activity
IT971_08725	COG0438	transferase activity, transferring glycosyl groups
IT971_08730	COG1846	Transcriptional regulator
IT971_08805	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IT971_08815	COG3448	diguanylate cyclase activity
IT971_08815	COG4175	Glycine betaine
IT971_08820	COG4176	ABC-type proline glycine betaine transport system permease component
IT971_08825	COG2113	Glycine betaine
IT971_08830	COG4176	ABC-type proline glycine betaine transport system permease component
IT971_08835	COG4175	Glycine betaine
IT971_08855	COG1840	ABC-type Fe3 transport system, periplasmic component
IT971_08860	COG1840	ABC-type Fe3 transport system, periplasmic component
IT971_08870	COG0303	'Molybdopterin
IT971_08875	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IT971_08885	COG0438	transferase activity, transferring glycosyl groups
IT971_08920	COG0747	negative chemotaxis
IT971_08925	COG0601	transmembrane transport
IT971_08930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT971_08935	COG2814	Major facilitator Superfamily
IT971_08945	COG2814	Major facilitator Superfamily
IT971_08950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT971_08950	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IT971_08955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IT971_08960	COG1393	Belongs to the ArsC family
IT971_08965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT971_08970	COG0405	Gamma-glutamyltransferase
IT971_08990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IT971_08995	COG0793	Belongs to the peptidase S41A family
IT971_09010	COG0557	exoribonuclease II activity
IT971_09015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IT971_09020	COG0758	DNA mediated transformation
IT971_09020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IT971_09035	COG1585	Membrane protein implicated in regulation of membrane protease activity
IT971_09040	COG2268	Band 7 protein
IT971_09045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IT971_09050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IT971_09075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IT971_09085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IT971_09095	COG0840	transmembrane signaling receptor activity
IT971_09105	COG2223	nitrite transmembrane transporter activity
IT971_09120	COG0583	DNA-binding transcription factor activity
IT971_09125	COG1435	thymidine kinase activity
IT971_09140	COG2995	paraquat-inducible protein a
IT971_09145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IT971_09145	COG3008	intermembrane lipid transfer
IT971_09160	COG4977	sequence-specific DNA binding
IT971_09165	COG2814	Major facilitator Superfamily
IT971_09370	COG1802	Transcriptional regulator
IT971_09370	COG4626	Terminase
IT971_09380	COG0740	serine-type endopeptidase activity
IT971_09560	COG0174	glutamine synthetase
IT971_09565	COG1012	belongs to the aldehyde dehydrogenase family
IT971_09570	COG1454	alcohol dehydrogenase
IT971_09575	COG0519	Catalyzes the synthesis of GMP from XMP
IT971_09575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT971_09580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT971_09585	COG0737	Belongs to the 5'-nucleotidase family
IT971_09590	COG1744	ABC transporter substrate-binding protein PnrA-like
IT971_09595	COG3845	ABC transporter
IT971_09605	COG1079	Belongs to the binding-protein-dependent transport system permease family
IT971_09620	COG0295	cytidine deaminase activity
IT971_09625	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IT971_09630	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IT971_09640	COG0471	metal ion transport
IT971_09655	COG1126	abc transporter atp-binding protein
IT971_09660	COG0765	amino acid transport
IT971_09665	COG4597	amino acid ABC transporter
IT971_09670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT971_09675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT971_09680	COG0521	Mo-molybdopterin cofactor biosynthetic process
IT971_09690	COG0840	transmembrane signaling receptor activity
IT971_09705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT971_09735	COG2814	Major facilitator Superfamily
IT971_09760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT971_09770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IT971_09780	COG1122	ATPase activity
IT971_09795	COG0310	cobalt ion transport
IT971_09825	COG1042	CoA-binding domain protein
IT971_09825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT971_09825	COG0045	succinate-CoA ligase (ADP-forming) activity
IT971_09840	COG4989	oxidoreductase activity
IT971_09855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IT971_09860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IT971_09865	COG1538	Outer membrane efflux protein
IT971_09875	COG0525	valine-tRNA ligase activity
IT971_09885	COG0512	Glutamine amidotransferase of anthranilate synthase
IT971_09900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT971_09910	COG0316	Belongs to the HesB IscA family
IT971_09925	COG1472	Belongs to the glycosyl hydrolase 3 family
IT971_09930	COG1994	Peptidase M50
IT971_09935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IT971_09940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IT971_09945	COG3842	ATPase activity
IT971_09950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT971_09955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT971_09960	COG0805	protein transport
IT971_09980	COG4942	peptidase
IT971_09990	COG1862	Preprotein translocase
IT971_09995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT971_10010	COG3737	Protein of unknown function (DUF498/DUF598)
IT971_10015	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IT971_10020	COG0668	transmembrane transport
IT971_10045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IT971_10050	COG0191	fructose-bisphosphate aldolase activity
IT971_10060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IT971_10065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IT971_10070	COG2188	Transcriptional regulator
IT971_10075	COG2971	BadF BadG BcrA BcrD
IT971_10080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IT971_10090	COG1175	transmembrane transport
IT971_10100	COG3842	ATPase activity
IT971_10110	COG3842	ATPase activity
IT971_10115	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT971_10120	COG1177	transmembrane transport
IT971_10135	COG0395	ABC-type sugar transport system, permease component
IT971_10140	COG3842	ATPase activity
IT971_10145	COG1956	GAF domain-containing protein
IT971_10150	COG0629	single-stranded DNA binding
IT971_10190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IT971_10195	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IT971_10200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IT971_10210	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IT971_10260	COG2951	lytic endotransglycosylase activity
IT971_10270	COG1686	Belongs to the peptidase S11 family
IT971_10275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IT971_10290	COG0084	hydrolase, TatD family'
IT971_10295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IT971_10295	COG0321	lipoyl(octanoyl) transferase activity
IT971_10305	COG5489	Protein of unknown function (DUF736)
IT971_10385	COG4644	lycopene metabolic process
IT971_10460	COG1846	Transcriptional regulator
IT971_10470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IT971_10475	COG1917	Cupin 2, conserved barrel domain protein
IT971_10480	COG0527	aspartate kinase activity
IT971_10485	COG3956	TIGRFAM MazG family protein
IT971_10490	COG0483	inositol monophosphate 1-phosphatase activity
IT971_10495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IT971_10510	COG0569	domain protein
IT971_10515	COG2204	response regulator
IT971_10555	COG1324	tolerance protein
IT971_10580	COG0776	regulation of translation
IT971_10590	COG0416	fatty acid biosynthetic process
IT971_10610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IT971_10615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IT971_10620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IT971_10625	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT971_10625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT971_10635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT971_10635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT971_10640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IT971_10650	COG0698	ribose 5-phosphate isomerase
IT971_10700	COG1024	Enoyl-CoA hydratase
IT971_10725	COG0113	porphobilinogen synthase activity
IT971_10730	COG1011	Hydrolase
IT971_10740	COG0318	PFAM AMP-dependent synthetase and ligase
IT971_10750	COG1012	belongs to the aldehyde dehydrogenase family
IT971_10755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT971_10760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IT971_10765	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IT971_10770	COG1360	Flagellar Motor Protein
IT971_10780	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT971_10785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_10795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IT971_10800	COG1381	Involved in DNA repair and RecF pathway recombination
IT971_10820	COG0571	ribonuclease III activity
IT971_10825	COG0681	Belongs to the peptidase S26 family
IT971_10835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IT971_10865	COG1573	uracil-dna glycosylase
IT971_10870	COG0514	ATP-dependent DNA helicase (RecQ)
IT971_10875	COG0386	Belongs to the glutathione peroxidase family
IT971_10880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IT971_10885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IT971_10890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT971_10895	COG0741	lytic transglycosylase activity
IT971_10895	COG0739	heme binding
IT971_10895	COG1196	nuclear chromosome segregation
IT971_10910	COG0739	heme binding
IT971_10915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IT971_10920	COG1546	Belongs to the CinA family
IT971_10920	COG1058	Belongs to the CinA family
IT971_10925	COG2867	negative regulation of translational initiation
IT971_10930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IT971_10935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT971_10940	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT971_10945	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT971_10945	COG0022	dehydrogenase e1 component
IT971_10950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IT971_10955	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IT971_10960	COG0148	phosphopyruvate hydratase activity
IT971_10980	COG0149	triose-phosphate isomerase activity
IT971_10985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT971_10990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IT971_10995	COG2861	carbohydrate metabolic process
IT971_11015	COG0315	cyclic pyranopterin monophosphate synthase activity
IT971_11025	COG2333	competence protein COMEC
IT971_11025	COG0658	competence protein
IT971_11030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT971_11035	COG0372	Belongs to the citrate synthase family
IT971_11045	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT971_11050	COG3494	Protein of unknown function (DUF1009)
IT971_11065	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT971_11080	COG0750	zinc metalloprotease
IT971_11085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IT971_11095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IT971_11105	COG0528	UMP kinase activity
IT971_11110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IT971_11135	COG0442	prolyl-tRNA aminoacylation
IT971_11150	COG0346	lactoylglutathione lyase activity
IT971_11185	COG0713	ATP synthesis coupled electron transport
IT971_11195	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT971_11200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IT971_11205	COG1034	ATP synthesis coupled electron transport
IT971_11210	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IT971_11215	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IT971_11230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT971_11235	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT971_11245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IT971_11260	COG0776	regulation of translation
IT971_11290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IT971_11290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IT971_11300	COG2205	protein histidine kinase activity
IT971_11300	COG2202	Pas domain
IT971_11315	COG2217	Heavy metal translocating P-type atpase
IT971_11320	COG2193	ferroxidase activity
IT971_11330	COG3046	protein related to deoxyribodipyrimidine photolyase
IT971_11350	COG1175	transmembrane transport
IT971_11355	COG0395	ABC-type sugar transport system, permease component
IT971_11360	COG3842	ATPase activity
IT971_11380	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IT971_11390	COG0166	Belongs to the GPI family
IT971_11405	COG0010	Belongs to the arginase family
IT971_11410	COG1012	belongs to the aldehyde dehydrogenase family
IT971_11415	COG1396	sequence-specific DNA binding
IT971_11415	COG1917	Cupin 2, conserved barrel domain protein
IT971_11420	COG0174	glutamine synthetase
IT971_11430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT971_11445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT971_11455	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IT971_11470	COG4176	ABC-type proline glycine betaine transport system permease component
IT971_11485	COG0583	DNA-binding transcription factor activity
IT971_11495	COG1177	transmembrane transport
IT971_11505	COG3842	ATPase activity
IT971_11510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT971_11515	COG3246	L-lysine catabolic process to acetate
IT971_11530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT971_11535	COG0251	oxidation-reduction process
IT971_11555	COG2423	ornithine cyclodeaminase activity
IT971_11560	COG0657	acetylesterase activity
IT971_11570	COG3616	Alanine racemase, N-terminal domain
IT971_11580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_11585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_11600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT971_11610	COG0729	surface antigen
IT971_11615	COG0189	ligase activity
IT971_11660	COG0183	Belongs to the thiolase family
IT971_11665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IT971_11670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IT971_11675	COG3485	protocatechuate 3,4-dioxygenase
IT971_11680	COG3485	protocatechuate 3,4-dioxygenase
IT971_11685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT971_11690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT971_11695	COG0583	DNA-binding transcription factor activity
IT971_11725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT971_11750	COG2814	Major facilitator Superfamily
IT971_11760	COG2375	cellular response to nickel ion
IT971_11790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IT971_11815	COG3769	mannosylglycerate metabolic process
IT971_11820	COG1215	transferase activity, transferring glycosyl groups
IT971_11835	COG0366	Alpha amylase catalytic
IT971_11845	COG0583	DNA-binding transcription factor activity
IT971_11855	COG0028	Belongs to the TPP enzyme family
IT971_11860	COG1414	Transcriptional regulator
IT971_11900	COG3041	Addiction module toxin RelE StbE family
IT971_11905	COG3077	Addiction module antitoxin, RelB DinJ family
IT971_11915	COG0210	DNA helicase
IT971_11940	COG2186	Transcriptional regulator
IT971_11945	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT971_11950	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT971_11955	COG1129	ABC transporter
IT971_11960	COG1879	ABC-type sugar transport system periplasmic component
IT971_11965	COG2017	converts alpha-aldose to the beta-anomer
IT971_11975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_11980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_11985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT971_11990	COG1802	Transcriptional regulator
IT971_12055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IT971_12070	COG1304	FMN binding
IT971_12080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_12085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT971_12090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_12100	COG0277	FAD linked oxidase domain protein
IT971_12110	COG0308	aminopeptidase N
IT971_12125	COG0628	permease
IT971_12130	COG1917	Cupin 2, conserved barrel domain protein
IT971_12130	COG2207	Transcriptional regulator
IT971_12140	COG1280	lysine exporter protein (LysE YggA)
IT971_12155	COG2205	protein histidine kinase activity
IT971_12165	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT971_12170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT971_12185	COG4977	sequence-specific DNA binding
IT971_12210	COG0848	biopolymer transport protein
IT971_12215	COG0848	biopolymer transport protein
IT971_12220	COG0811	peptide transport
IT971_12240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IT971_12245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IT971_12250	COG0697	spore germination
IT971_12275	COG0418	dihydroorotase activity
IT971_12280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IT971_12300	COG0436	Aminotransferase
IT971_12315	COG3706	GGDEF domain
IT971_12325	COG1765	OsmC-like protein
IT971_12350	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IT971_12365	COG1802	Transcriptional regulator
IT971_12370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_12380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_12385	COG5002	protein histidine kinase activity
IT971_12385	COG5001	Diguanylate cyclase
IT971_12395	COG0702	epimerase
IT971_12410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT971_12425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT971_12440	COG5001	Diguanylate cyclase
IT971_12440	COG3300	MHYT domain
IT971_12485	COG0482	sulfurtransferase activity
IT971_12490	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IT971_12495	COG2975	iron-sulfur cluster assembly
IT971_12500	COG0633	Ferredoxin
IT971_12515	COG0316	Belongs to the HesB IscA family
IT971_12520	COG0822	iron-sulfur transferase activity
IT971_12525	COG1104	cysteine desulfurase activity
IT971_12530	COG1104	cysteine desulfurase activity
IT971_12535	COG1959	2 iron, 2 sulfur cluster binding
IT971_12540	COG1045	serine acetyltransferase
IT971_12545	COG2945	thiolester hydrolase activity
IT971_12550	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IT971_12565	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IT971_12570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IT971_12580	COG2833	Protein of unknown function (DUF455)
IT971_12590	COG0625	glutathione transferase activity
IT971_12625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IT971_12630	COG0860	N-Acetylmuramoyl-L-alanine amidase
IT971_12635	COG1530	ribonuclease E activity
IT971_12640	COG0436	Aminotransferase
IT971_12650	COG0501	Belongs to the peptidase M48B family
IT971_12670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IT971_12675	COG0511	ligase activity, forming carbon-carbon bonds
IT971_12680	COG0439	Biotin carboxylase
IT971_12685	COG1280	lysine exporter protein (LysE YggA)
IT971_12690	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IT971_12700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT971_12730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IT971_12745	COG1686	Belongs to the peptidase S11 family
IT971_12755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IT971_12765	COG0484	heat shock protein binding
IT971_12785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT971_12790	COG2342	PFAM TM1410 hypothetical-related protein
IT971_12825	COG1522	sequence-specific DNA binding
IT971_12835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT971_12840	COG1024	Enoyl-CoA hydratase
IT971_12845	COG4770	biotin carboxylase activity
IT971_12860	COG0840	transmembrane signaling receptor activity
IT971_12880	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT971_12895	COG0583	DNA-binding transcription factor activity
IT971_12910	COG2084	Dehydrogenase
IT971_12915	COG0793	Belongs to the peptidase S41A family
IT971_12920	COG1960	acyl-CoA dehydrogenase activity
IT971_12925	COG0795	lipopolysaccharide-transporting ATPase activity
IT971_12935	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IT971_12940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT971_12950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IT971_12955	COG0194	GDP metabolic process
IT971_12960	COG1561	YicC-like family, N-terminal region
IT971_12970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IT971_12975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT971_12995	COG0360	Binds together with S18 to 16S ribosomal RNA
IT971_13000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IT971_13010	COG0359	binds to the 23S rRNA
IT971_13015	COG0305	Participates in initiation and elongation during chromosome replication
IT971_13020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IT971_13025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IT971_13030	COG1127	ABC transporter
IT971_13045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IT971_13050	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_13060	COG0583	DNA-binding transcription factor activity
IT971_13065	COG0667	Aldo Keto reductase
IT971_13070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT971_13075	COG1160	GTP binding
IT971_13105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IT971_13110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IT971_13110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IT971_13115	COG4993	Dehydrogenase
IT971_13120	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IT971_13125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IT971_13135	COG1902	pentaerythritol trinitrate reductase activity
IT971_13145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IT971_13150	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IT971_13160	COG1091	dTDP-4-dehydrorhamnose reductase activity
IT971_13170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IT971_13175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IT971_13180	COG0546	phosphoglycolate phosphatase activity
IT971_13190	COG0129	dihydroxy-acid dehydratase activity
IT971_13195	COG4214	carbohydrate transport
IT971_13205	COG4213	ABC transporter substrate-binding protein
IT971_13220	COG0237	dephospho-CoA kinase activity
IT971_13230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT971_13245	COG1234	tRNA 3'-trailer cleavage
IT971_13255	COG4149	molybdate abc transporter
IT971_13260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IT971_13335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IT971_13360	COG1283	sodium-dependent phosphate transmembrane transporter activity
IT971_13375	COG0367	asparagine synthase
IT971_13380	COG1522	sequence-specific DNA binding
IT971_13385	COG3284	Transcriptional regulator
IT971_13390	COG1012	belongs to the aldehyde dehydrogenase family
IT971_13400	COG2855	membrane
IT971_13405	COG0583	DNA-binding transcription factor activity
IT971_13410	COG1271	oxidase subunit
IT971_13415	COG1294	oxidase, subunit
IT971_13430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT971_13445	COG1012	belongs to the aldehyde dehydrogenase family
IT971_13450	COG3724	N-succinylarginine dihydrolase activity
IT971_13460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT971_13465	COG1522	sequence-specific DNA binding
IT971_13470	COG0175	sulfate reduction
IT971_13495	COG0587	DNA-directed DNA polymerase activity
IT971_13505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT971_13515	COG0747	negative chemotaxis
IT971_13530	COG1116	anion transmembrane transporter activity
IT971_13530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT971_13540	COG2223	nitrite transmembrane transporter activity
IT971_13545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT971_13550	COG2146	nitrite reductase [NAD(P)H] activity
IT971_13555	COG0243	molybdopterin cofactor binding
IT971_13560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IT971_13560	COG1648	precorrin-2 dehydrogenase activity
IT971_13570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IT971_13585	COG2827	Endonuclease containing a URI domain
IT971_13590	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_13595	COG0800	Aldolase
IT971_13600	COG3734	2-keto-3-deoxy-galactonokinase
IT971_13610	COG4638	Rieske (2fe-2S)
IT971_13615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT971_13620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT971_13630	COG2086	electron transfer activity
IT971_13640	COG0788	formyltetrahydrofolate deformylase activity
IT971_13690	COG3938	Belongs to the proline racemase family
IT971_13705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT971_13710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT971_13715	COG0438	transferase activity, transferring glycosyl groups
IT971_13730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IT971_13755	COG3842	ATPase activity
IT971_13770	COG0395	ABC-type sugar transport system, permease component
IT971_13825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT971_13830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT971_13845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT971_13850	COG1309	transcriptional regulator
IT971_13870	COG0493	'glutamate synthase
IT971_13890	COG4208	sulfate ABC transporter
IT971_13905	COG0826	peptidase U32
IT971_13920	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IT971_13940	COG3386	PFAM SMP-30 Gluconolaconase
IT971_13945	COG1120	ATPase activity
IT971_13960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT971_13985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT971_14000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_14005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT971_14025	COG2017	converts alpha-aldose to the beta-anomer
IT971_14030	COG2186	Transcriptional regulator
IT971_14035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT971_14040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IT971_14055	COG0129	dihydroxy-acid dehydratase activity
IT971_14060	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_14065	COG4213	ABC transporter substrate-binding protein
IT971_14070	COG4214	carbohydrate transport
IT971_14085	COG1940	carbohydrate kinase activity
IT971_14090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IT971_14100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT971_14125	COG1609	Transcriptional regulator
IT971_14130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IT971_14140	COG3383	formate dehydrogenase (NAD+) activity
IT971_14150	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IT971_14155	COG0583	DNA-binding transcription factor activity
IT971_14160	COG2223	nitrite transmembrane transporter activity
IT971_14165	COG4191	Histidine kinase
IT971_14170	COG2204	response regulator
IT971_14175	COG1629	transport
IT971_14175	COG4774	siderophore transport
IT971_14185	COG4178	(ABC) transporter
IT971_14210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IT971_14220	COG3597	protein domain associated with
IT971_14235	COG3597	protein domain associated with
IT971_14265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT971_14305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT971_14310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT971_14320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IT971_14330	COG2986	histidine ammonia-lyase
IT971_14360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT971_14370	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_14375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT971_14395	COG0411	ABC transporter
IT971_14415	COG3483	tryptophan 2,3-dioxygenase activity
IT971_14430	COG1960	acyl-CoA dehydrogenase activity
IT971_14470	COG0673	inositol 2-dehydrogenase activity
IT971_14475	COG3718	enzyme involved in inositol metabolism
IT971_14485	COG3962	Belongs to the TPP enzyme family
IT971_14490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT971_14525	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IT971_14530	COG1609	Transcriptional regulator
IT971_14535	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_14555	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IT971_14560	COG0473	3-isopropylmalate dehydrogenase activity
IT971_14595	COG3976	FMN-binding domain protein
IT971_14595	COG1053	succinate dehydrogenase
IT971_14595	COG0431	NADPH-dependent FMN reductase
IT971_14600	COG1802	Transcriptional regulator
IT971_14605	COG1132	(ABC) transporter
IT971_14610	COG5002	protein histidine kinase activity
IT971_14610	COG5000	phosphorelay sensor kinase activity
IT971_14615	COG0745	RESPONSE REGULATOR receiver
IT971_14630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT971_14685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_14700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_14710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_14730	COG4948	Mandelate Racemase Muconate Lactonizing
IT971_14740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT971_14740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_14750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT971_14755	COG1802	Transcriptional regulator
IT971_14765	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_14770	COG2390	Transcriptional regulator
IT971_14780	COG1175	transmembrane transport
IT971_14795	COG1063	alcohol dehydrogenase
IT971_14800	COG3842	ATPase activity
IT971_14805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT971_14810	COG1070	Carbohydrate kinase
IT971_14815	COG2205	protein histidine kinase activity
IT971_14820	COG0745	RESPONSE REGULATOR receiver
IT971_14825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT971_14835	COG1538	Outer membrane efflux protein
IT971_14860	COG1749	Flagellar hook protein flgE
IT971_14895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IT971_14915	COG4774	siderophore transport
IT971_14920	COG1120	ATPase activity
IT971_14925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IT971_14935	COG4114	ferric iron reductase
IT971_14950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IT971_14965	COG0626	cystathionine gamma-synthase activity
IT971_15185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT971_15210	COG0789	Transcriptional regulator
IT971_15230	COG0785	Cytochrome C biogenesis protein
IT971_15245	COG1999	signal sequence binding
IT971_15260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT971_15265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT971_15305	COG2132	Multicopper oxidase
IT971_15350	COG1196	nuclear chromosome segregation
IT971_15385	COG1192	Involved in chromosome partitioning
IT971_15445	COG0741	lytic transglycosylase activity
IT971_15445	COG1196	nuclear chromosome segregation
IT971_15445	COG0739	heme binding
IT971_15450	COG0583	DNA-binding transcription factor activity
IT971_15455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT971_15460	COG4597	amino acid ABC transporter
IT971_15465	COG0765	amino acid transport
IT971_15470	COG1126	abc transporter atp-binding protein
IT971_15485	COG1965	Belongs to the frataxin family
IT971_15490	COG0254	rRNA binding
IT971_15510	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_15510	COG3321	synthase
IT971_15510	COG0604	alcohol dehydrogenase
IT971_15520	COG1349	DNA-binding transcription factor activity
IT971_15525	COG0583	DNA-binding transcription factor activity
IT971_15585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IT971_15590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IT971_15605	COG0242	peptide deformylase activity
IT971_15610	COG1566	PFAM secretion protein HlyD family protein
IT971_15620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IT971_15625	COG2056	Na+-H+ antiporter family
IT971_15650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IT971_15675	COG0542	response to heat
IT971_15695	COG2890	protein-(glutamine-N5) methyltransferase activity
IT971_15700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IT971_15705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IT971_15710	COG0124	histidyl-tRNA synthetase
IT971_15715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IT971_15725	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
IT971_15730	COG2070	2-Nitropropane dioxygenase
IT971_15740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT971_15750	COG0500	methyltransferase
IT971_15760	COG1785	Belongs to the alkaline phosphatase family
IT971_15770	COG0577	efflux transmembrane transporter activity
IT971_15770	COG1136	(ABC) transporter
IT971_15795	COG2186	Transcriptional regulator
IT971_15810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IT971_15815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IT971_15820	COG0583	DNA-binding transcription factor activity
IT971_15825	COG0625	glutathione transferase activity
IT971_15830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT971_15830	COG1017	nitric oxide dioxygenase activity
IT971_15840	COG1489	DNA binding
IT971_15845	COG0024	Methionine aminopeptidase
IT971_15850	COG2003	Belongs to the UPF0758 family
IT971_15855	COG0346	lactoylglutathione lyase activity
IT971_15885	COG4166	transmembrane transport
IT971_15890	COG0601	transmembrane transport
IT971_15895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT971_15910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT971_15935	COG2169	Transcriptional regulator
IT971_15935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IT971_15940	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_15945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IT971_15950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IT971_15975	COG2197	response regulator
IT971_15990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IT971_15995	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IT971_16000	COG0047	phosphoribosylformylglycinamidine synthase activity
IT971_16005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IT971_16025	COG0489	protein tyrosine kinase activity
IT971_16030	COG0330	HflC and HflK could
IT971_16050	COG3830	Belongs to the UPF0237 family
IT971_16050	COG0560	Phosphoserine phosphatase
IT971_16060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IT971_16065	COG0028	Belongs to the TPP enzyme family
IT971_16070	COG0440	acetolactate synthase activity
IT971_16075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IT971_16080	COG2313	pseudouridylate synthase activity
IT971_16095	COG0415	Belongs to the DNA photolyase family
IT971_16115	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IT971_16120	COG1530	ribonuclease E activity
IT971_16140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IT971_16150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IT971_16205	COG2197	response regulator
IT971_16215	COG0604	alcohol dehydrogenase
IT971_16220	COG3339	Conserved Protein
IT971_16230	COG0463	Glycosyl transferase, family 2
IT971_16245	COG0354	folic acid binding
IT971_16250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT971_16250	COG0574	Belongs to the PEP-utilizing enzyme family
IT971_16260	COG0752	glycyl-tRNA synthetase alpha subunit
IT971_16275	COG2890	protein-(glutamine-N5) methyltransferase activity
IT971_16285	COG0142	geranyltranstransferase activity
IT971_16300	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT971_16320	COG3474	cytochrome
IT971_16330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IT971_16350	COG2358	TRAP transporter, solute receptor (TAXI family
IT971_16355	COG3246	L-lysine catabolic process to acetate
IT971_16360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT971_16370	COG5002	protein histidine kinase activity
IT971_16370	COG2205	protein histidine kinase activity
IT971_16370	COG0784	Response regulator, receiver
IT971_16375	COG0367	asparagine synthase
IT971_16385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IT971_16390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IT971_16410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IT971_16420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IT971_16425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IT971_16430	COG0306	phosphate transporter
IT971_16500	COG0277	FAD linked oxidase domain protein
IT971_16520	COG0559	Belongs to the binding-protein-dependent transport system permease family
IT971_16545	COG4974	Belongs to the 'phage' integrase family
IT971_16550	COG0069	glutamate synthase activity
IT971_16555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT971_16590	COG0840	transmembrane signaling receptor activity
IT971_16595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IT971_16600	COG0488	(ABC) transporter
IT971_16615	COG3023	N-Acetylmuramoyl-L-alanine amidase
IT971_16635	COG1335	isochorismatase
IT971_16640	COG4977	sequence-specific DNA binding
IT971_16660	COG2001	Belongs to the MraZ family
IT971_16665	COG0275	rRNA processing
IT971_16680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IT971_16695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IT971_16715	COG0640	Transcriptional regulator
IT971_16740	COG2826	transposase and inactivated derivatives, IS30 family
IT971_16750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IT971_16760	COG1181	Belongs to the D-alanine--D-alanine ligase family
IT971_16765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IT971_16770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IT971_16795	COG4948	Mandelate Racemase Muconate Lactonizing
IT971_16800	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_16805	COG1063	alcohol dehydrogenase
IT971_16815	COG3842	ATPase activity
IT971_16825	COG1175	transmembrane transport
IT971_16830	COG1653	transport
IT971_16845	COG4608	Belongs to the ABC transporter superfamily
IT971_16850	COG0444	Belongs to the ABC transporter superfamily
IT971_16855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT971_16860	COG0601	transmembrane transport
IT971_16865	COG0747	negative chemotaxis
IT971_16870	COG1414	Transcriptional regulator
IT971_16875	COG0849	cell division
IT971_16880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IT971_16890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT971_16900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IT971_16920	COG0697	spore germination
IT971_16930	COG0667	Aldo Keto reductase
IT971_16935	COG0006	proline dipeptidase activity
IT971_16945	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_16950	COG0730	response to heat
IT971_16955	COG2264	protein methyltransferase activity
IT971_16960	COG0210	DNA helicase
IT971_16985	COG2814	Major facilitator Superfamily
IT971_16990	COG0646	methionine synthase
IT971_16990	COG1410	methionine synthase
IT971_17005	COG2226	methyltransferase
IT971_17010	COG2853	Lipoprotein
IT971_17020	COG0488	(ABC) transporter
IT971_17030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT971_17050	COG0725	ABC transporter, periplasmic molybdate-binding protein
IT971_17055	COG4149	molybdate abc transporter
IT971_17060	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IT971_17070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IT971_17085	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT971_17085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT971_17100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT971_17120	COG2010	Cytochrome c
IT971_17125	COG1648	precorrin-2 dehydrogenase activity
IT971_17125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IT971_17130	COG2010	Cytochrome c
IT971_17160	COG0535	radical SAM domain protein
IT971_17175	COG1845	cytochrome c oxidase, subunit III
IT971_17185	COG0714	Associated with various cellular activities
IT971_17210	COG0826	peptidase U32
IT971_17215	COG0826	peptidase U32
IT971_17245	COG4263	nitrous-oxide reductase activity
IT971_17250	COG0348	domain, Protein
IT971_17250	COG3901	Regulator of nitric oxide reductase transcription
IT971_17255	COG0745	RESPONSE REGULATOR receiver
IT971_17260	COG2205	protein histidine kinase activity
IT971_17265	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IT971_17270	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IT971_17275	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IT971_17285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IT971_17290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IT971_17305	COG0356	it plays a direct role in the translocation of protons across the membrane
IT971_17315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IT971_17315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IT971_17320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IT971_17330	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IT971_17345	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IT971_17355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IT971_17370	COG0505	Belongs to the CarA family
IT971_17375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IT971_17380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT971_17390	COG1522	sequence-specific DNA binding
IT971_17395	COG0492	ferredoxin-NADP+ reductase activity
IT971_17400	COG0583	DNA-binding transcription factor activity
IT971_17405	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IT971_17410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IT971_17415	COG0783	Belongs to the Dps family
IT971_17420	COG0154	amidase activity
IT971_17445	COG4336	lyase activity
IT971_17450	COG0583	DNA-binding transcription factor activity
IT971_17455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IT971_17465	COG0556	nucleotide-excision repair
IT971_17470	COG0436	Aminotransferase
IT971_17480	COG0367	asparagine synthase
IT971_17485	COG1215	transferase activity, transferring glycosyl groups
IT971_17490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT971_17495	COG0450	alkyl hydroperoxide reductase
IT971_17500	COG0583	DNA-binding transcription factor activity
IT971_17515	COG4459	periplasmic nitrate reductase
IT971_17535	COG3043	anaerobic respiration
IT971_17540	COG3005	denitrification pathway
IT971_17545	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IT971_17545	COG1618	nucleotide phosphatase activity, acting on free nucleotides
IT971_17550	COG0519	Catalyzes the synthesis of GMP from XMP
IT971_17550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT971_17565	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IT971_17570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IT971_17625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT971_17655	COG0745	RESPONSE REGULATOR receiver
IT971_17660	COG1846	Transcriptional regulator
IT971_17665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT971_17670	COG0625	glutathione transferase activity
IT971_17675	COG3119	arylsulfatase activity
IT971_17680	COG0583	DNA-binding transcription factor activity
IT971_17690	COG0408	coproporphyrinogen oxidase activity
IT971_17695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IT971_17720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT971_17745	COG1072	(Pantothenic acid kinase))
IT971_17775	COG1522	sequence-specific DNA binding
IT971_17790	COG2186	Transcriptional regulator
IT971_17795	COG4597	amino acid ABC transporter
IT971_17800	COG0765	amino acid transport
IT971_17805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT971_17810	COG1126	abc transporter atp-binding protein
IT971_17815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IT971_17835	COG1396	sequence-specific DNA binding
IT971_17850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IT971_17855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IT971_17860	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IT971_17885	COG1088	dTDP-glucose 4,6-dehydratase activity
IT971_17900	COG0367	asparagine synthase
IT971_17910	COG0367	asparagine synthase
IT971_17915	COG0438	transferase activity, transferring glycosyl groups
IT971_17955	COG1321	iron dependent repressor
IT971_17960	COG0803	Belongs to the bacterial solute-binding protein 9 family
IT971_17965	COG1121	(ABC) transporter
IT971_17970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT971_17970	COG1321	iron dependent repressor
IT971_17975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT971_17995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IT971_18010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IT971_18015	COG0612	Peptidase, M16
IT971_18020	COG0612	Peptidase, M16
IT971_18030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IT971_18040	COG0196	riboflavin kinase activity
IT971_18045	COG2030	dehydratase
IT971_18050	COG2226	methyltransferase
IT971_18100	COG0737	Belongs to the 5'-nucleotidase family
IT971_18110	COG2207	Transcriptional regulator
IT971_18125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IT971_18135	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IT971_18140	COG1177	transmembrane transport
IT971_18145	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT971_18150	COG3842	ATPase activity
IT971_18155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT971_18160	COG1960	acyl-CoA dehydrogenase activity
IT971_18165	COG0583	DNA-binding transcription factor activity
IT971_18180	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IT971_18190	COG1335	isochorismatase
IT971_18195	COG1335	isochorismatase
IT971_18255	COG2205	protein histidine kinase activity
IT971_18255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT971_18265	COG4251	negative regulation of phosphorylation
IT971_18275	COG2832	Protein of unknown function (DUF454)
IT971_18305	COG1320	monovalent cation:proton antiporter activity
IT971_18310	COG2212	antiporter activity
IT971_18315	COG1863	multisubunit Na H antiporter MnhE subunit
IT971_18320	COG0651	ATP synthesis coupled electron transport
IT971_18325	COG1006	Multisubunit Na H antiporter MnhC subunit
IT971_18330	COG2111	Na H antiporter
IT971_18330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT971_18340	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IT971_18385	COG0733	neurotransmitter:sodium symporter activity
IT971_18400	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT971_18405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT971_18415	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IT971_18420	COG1138	Cytochrome C-type biogenesis protein
IT971_18425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT971_18430	COG3088	subunit of a heme lyase
IT971_18435	COG4235	cytochrome complex assembly
IT971_18435	COG3088	subunit of a heme lyase
IT971_18440	COG1349	DNA-binding transcription factor activity
IT971_18445	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IT971_18455	COG1129	ABC transporter
IT971_18460	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT971_18465	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT971_18485	COG0739	heme binding
IT971_18485	COG0741	lytic transglycosylase activity
IT971_18485	COG1196	nuclear chromosome segregation
IT971_18490	COG1573	uracil-dna glycosylase
IT971_18500	COG1012	belongs to the aldehyde dehydrogenase family
IT971_18510	COG0583	DNA-binding transcription factor activity
IT971_18525	COG1473	amidohydrolase
IT971_18565	COG3142	Participates in the control of copper homeostasis
IT971_18570	COG1940	carbohydrate kinase activity
IT971_18575	COG0612	Peptidase, M16
IT971_18585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT971_18610	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IT971_18620	COG0109	protoheme IX farnesyltransferase activity
IT971_18625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT971_18630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IT971_18640	COG1678	Uncharacterized ACR, COG1678
IT971_18645	COG4232	protein-disulfide reductase activity
IT971_18650	COG0678	peroxiredoxin activity
IT971_18650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IT971_18665	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IT971_18670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IT971_18675	COG0509	glycine decarboxylation via glycine cleavage system
IT971_18680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT971_18690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IT971_18710	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT971_18710	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT971_18715	COG0604	alcohol dehydrogenase
IT971_18735	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IT971_18740	COG0625	glutathione transferase activity
IT971_18745	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IT971_18750	COG1116	anion transmembrane transporter activity
IT971_18755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT971_18760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT971_18765	COG3604	Transcriptional regulator
IT971_18775	COG2096	Adenosyltransferase
IT971_18790	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT971_18795	COG1070	Carbohydrate kinase
IT971_18800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT971_18805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT971_18820	COG0019	diaminopimelate decarboxylase activity
IT971_18840	COG2207	Transcriptional regulator
IT971_18860	COG2884	Cell division ATP-binding protein ftsE
IT971_18890	COG0697	spore germination
IT971_18895	COG0287	Prephenate dehydrogenase
IT971_18910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT971_18915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT971_18915	COG2813	Specifically methylates the guanine in position
IT971_18930	COG0314	molybdopterin synthase activity
IT971_18935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IT971_18940	COG2233	PERMEase
IT971_18950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IT971_18955	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_18970	COG0745	RESPONSE REGULATOR receiver
IT971_18985	COG0581	inorganic phosphate transmembrane transporter activity
IT971_18990	COG0573	inorganic phosphate transmembrane transporter activity
IT971_18995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IT971_19005	COG0247	lactate metabolic process
IT971_19010	COG0277	FAD linked oxidase domain protein
IT971_19015	COG0277	FAD linked oxidase domain protein
IT971_19020	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IT971_19035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT971_19045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IT971_19060	COG0747	negative chemotaxis
IT971_19095	COG1968	undecaprenyl-diphosphatase activity
IT971_19100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT971_19105	COG0640	Transcriptional regulator
IT971_19115	COG0740	serine-type endopeptidase activity
IT971_19140	COG0778	Nitroreductase
IT971_19155	COG1546	Belongs to the CinA family
IT971_19155	COG1058	Belongs to the CinA family
IT971_19195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT971_19200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IT971_19210	COG1639	'signal transduction protein
IT971_19225	COG1609	Transcriptional regulator
IT971_19230	COG1653	transport
IT971_19240	COG0395	ABC-type sugar transport system, permease component
IT971_19245	COG3507	Belongs to the glycosyl hydrolase 43 family
IT971_19265	COG1742	UPF0060 membrane protein
IT971_19275	COG1522	sequence-specific DNA binding
IT971_19280	COG3186	Phenylalanine-4-hydroxylase
IT971_19300	COG1703	isobutyryl-CoA mutase activity
IT971_19325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IT971_19355	COG2095	MarC family integral membrane protein
IT971_19360	COG0617	tRNA 3'-terminal CCA addition
IT971_19360	COG3620	sequence-specific DNA binding
IT971_19360	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IT971_19385	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_19395	COG0583	DNA-binding transcription factor activity
IT971_19400	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IT971_19410	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IT971_19415	COG1122	ATPase activity
IT971_19420	COG1268	BioY protein
IT971_19425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IT971_19430	COG0830	nickel cation binding
IT971_19435	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IT971_19440	COG0804	urea catabolic process
IT971_19445	COG0832	Belongs to the urease beta subunit family
IT971_19450	COG0831	urea catabolic process
IT971_19455	COG0829	nickel cation binding
IT971_19465	COG0411	ABC transporter
IT971_19500	COG0583	DNA-binding transcription factor activity
IT971_19515	COG0840	transmembrane signaling receptor activity
IT971_19540	COG3845	ABC transporter
IT971_19545	COG0590	tRNA wobble adenosine to inosine editing
IT971_19555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT971_19575	COG3195	allantoin biosynthetic process
IT971_19575	COG3648	Uricase
IT971_19580	COG4266	Belongs to the allantoicase family
IT971_19590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT971_19605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IT971_19625	COG2030	dehydratase
IT971_19630	COG2301	Belongs to the HpcH HpaI aldolase family
IT971_19700	COG1842	Phage shock protein A
IT971_19705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IT971_19720	COG1960	acyl-CoA dehydrogenase activity
IT971_19725	COG0288	reversible hydration of carbon dioxide
IT971_19740	COG0183	Belongs to the thiolase family
IT971_19745	COG1960	acyl-CoA dehydrogenase activity
IT971_19760	COG0513	Belongs to the DEAD box helicase family
IT971_19775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IT971_19780	COG3474	cytochrome
IT971_19815	COG1522	sequence-specific DNA binding
IT971_19840	COG2154	pterin-4-alpha-carbinolamine dehydratase
IT971_19845	COG1573	uracil-dna glycosylase
IT971_19855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT971_19875	COG4172	Belongs to the ABC transporter superfamily
IT971_19880	COG4239	(ABC) transporter, permease
IT971_19885	COG4174	ABC transporter (Permease)
IT971_19890	COG4166	transmembrane transport
IT971_19895	COG0583	DNA-binding transcription factor activity
IT971_19910	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_19910	COG3321	synthase
IT971_19910	COG0604	alcohol dehydrogenase
IT971_19940	COG0693	protein deglycase activity
IT971_19965	COG1522	sequence-specific DNA binding
IT971_19970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_19980	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT971_19995	COG2986	histidine ammonia-lyase
IT971_20000	COG1228	amidohydrolase
IT971_20020	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IT971_20025	COG1741	Belongs to the pirin family
IT971_20030	COG0667	Aldo Keto reductase
IT971_20050	COG4181	ATPase activity
IT971_20055	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IT971_20060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT971_20070	COG0670	Belongs to the BI1 family
IT971_20080	COG0501	Belongs to the peptidase M48B family
IT971_20105	COG2902	Dehydrogenase
IT971_20110	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IT971_20140	COG3118	belongs to the thioredoxin family
IT971_20150	COG2835	tetraacyldisaccharide 4'-kinase activity
IT971_20160	COG3047	cAMP biosynthetic process
IT971_20165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT971_20175	COG0004	ammonium transporteR
IT971_20205	COG1074	ATP-dependent DNA helicase activity
IT971_20210	COG2887	Belongs to the helicase family. UvrD subfamily
IT971_20215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IT971_20225	COG0802	atpase or kinase
IT971_20245	COG1028	Short-chain dehydrogenase reductase Sdr
IT971_20255	COG1733	regulation of RNA biosynthetic process
IT971_20260	COG4702	Belongs to the UPF0303 family
IT971_20265	COG0481	GTPase activity
IT971_20270	COG4251	negative regulation of phosphorylation
IT971_20280	COG0072	phenylalanine-tRNA ligase activity
IT971_20285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IT971_20290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IT971_20295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IT971_20305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IT971_20340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IT971_20350	COG0181	hydroxymethylbilane synthase activity
IT971_20370	COG0138	bifunctional purine biosynthesis protein purh
IT971_20380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IT971_20390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IT971_20400	COG2183	response to ionizing radiation
IT971_20415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IT971_20425	COG1012	belongs to the aldehyde dehydrogenase family
IT971_20445	COG0583	DNA-binding transcription factor activity
IT971_20450	COG0840	transmembrane signaling receptor activity
IT971_20455	COG2807	transmembrane transport
IT971_20485	COG2067	long-chain fatty acid transport protein
IT971_20490	COG0318	PFAM AMP-dependent synthetase and ligase
IT971_20495	COG0789	Transcriptional regulator
IT971_20500	COG0183	Belongs to the thiolase family
IT971_20505	COG1024	Enoyl-CoA hydratase
IT971_20505	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT971_20510	COG1960	acyl-CoA dehydrogenase activity
IT971_20520	COG1024	Enoyl-CoA hydratase
IT971_20525	COG0300	oxidoreductase activity
IT971_20535	COG2943	transferase activity, transferring hexosyl groups
IT971_20565	COG0730	response to heat
IT971_20570	COG2186	Transcriptional regulator
IT971_20580	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT971_20595	COG3842	ATPase activity
IT971_20665	COG0583	DNA-binding transcription factor activity
IT971_20670	COG1741	Belongs to the pirin family
IT971_20700	COG2200	EAL domain
IT971_20745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT971_20755	COG3181	Tripartite tricarboxylate transporter family receptor
IT971_20775	COG3180	Ammonia monooxygenase
IT971_20790	COG1596	polysaccharide export
IT971_20795	COG0028	Belongs to the TPP enzyme family
IT971_20820	COG1131	(ABC) transporter
IT971_20830	COG0133	tryptophan synthase activity
IT971_20840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IT971_20845	COG0285	dihydrofolate synthase activity
IT971_20855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT971_20855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT971_20860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IT971_20880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IT971_20890	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IT971_20895	COG0792	nuclease activity
IT971_20920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT971_20925	COG1217	gtp-binding protein TYPA
IT971_20930	COG2211	Major facilitator Superfamily
IT971_20935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT971_20940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IT971_20950	COG1137	ATPase activity
IT971_20965	COG0517	IMP dehydrogenase activity
IT971_20965	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IT971_20990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IT971_20995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IT971_21000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IT971_21005	COG1420	regulation of RNA biosynthetic process
IT971_21045	COG0583	DNA-binding transcription factor activity
IT971_21060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IT971_21075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IT971_21080	COG2992	FlgJ-related protein
IT971_21095	COG0280	phosphate acetyltransferase
IT971_21095	COG0281	malic enzyme
IT971_21105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IT971_21115	COG0728	peptidoglycan biosynthetic process
IT971_21120	COG0180	Tryptophanyl-tRNA synthetase
IT971_21135	COG0745	RESPONSE REGULATOR receiver
IT971_21145	COG0352	thiamine-phosphate diphosphorylase activity
IT971_21210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IT971_21225	COG1331	Highly conserved protein containing a thioredoxin domain
IT971_21240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT971_21250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IT971_21275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IT971_21280	COG0237	dephospho-CoA kinase activity
IT971_21290	COG0424	maF-like protein
IT971_21295	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IT971_21310	COG1981	membrane
IT971_21315	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IT971_21320	COG3030	protein affecting phage T7 exclusion by the F plasmid
IT971_21415	COG1396	sequence-specific DNA binding
IT971_21425	COG0840	transmembrane signaling receptor activity
IT971_21430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT971_21435	COG2358	TRAP transporter, solute receptor (TAXI family
IT971_21500	COG0596	Alpha beta hydrolase
IT971_21525	COG0464	growth
IT971_21565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IT971_21590	COG0583	DNA-binding transcription factor activity
IT971_21595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT971_21625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IT971_21635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IT971_21645	COG0131	Imidazoleglycerol-phosphate dehydratase
IT971_21660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IT971_21670	COG5002	protein histidine kinase activity
IT971_21685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IT971_21690	COG0756	dUTP diphosphatase activity
IT971_21695	COG1959	2 iron, 2 sulfur cluster binding
IT971_21705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IT971_21715	COG1280	lysine exporter protein (LysE YggA)
IT971_21725	COG1285	pathogenesis
IT971_21730	COG1609	Transcriptional regulator
IT971_21735	COG2723	6-phospho-beta-galactosidase activity
IT971_21740	COG1653	transport
IT971_21745	COG1175	transmembrane transport
IT971_21755	COG3842	ATPase activity
IT971_21800	COG1702	phosphate starvation-inducible protein PhoH
IT971_21810	COG1253	flavin adenine dinucleotide binding
IT971_21815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IT971_21820	COG1396	sequence-specific DNA binding
IT971_21825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IT971_21830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IT971_21835	COG1595	DNA-templated transcription, initiation
IT971_21845	COG1629	transport
IT971_21845	COG4206	TonB-dependent receptor
IT971_21855	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
IT971_21860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT971_21880	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IT971_21895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IT971_21900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IT971_21905	COG1185	polyribonucleotide nucleotidyltransferase activity
IT971_21920	COG1592	Rubrerythrin
IT971_21930	COG1120	ATPase activity
IT971_21935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT971_21945	COG2226	methyltransferase
IT971_21955	COG2186	Transcriptional regulator
IT971_21975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IT971_21980	COG1268	BioY protein
IT971_21995	COG1305	Transglutaminase-like
IT971_22005	COG2308	Evidence 4 Homologs of previously reported genes of
IT971_22010	COG2875	Belongs to the precorrin methyltransferase family
IT971_22035	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IT971_22040	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IT971_22055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT971_22065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IT971_22070	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IT971_22115	COG1492	cobalamin metabolic process
IT971_22160	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IT971_22175	COG1999	signal sequence binding
IT971_22180	COG1797	cobyrinic acid a,c-diamide synthase activity
IT971_22185	COG2983	Belongs to the UPF0260 family
IT971_22195	COG1234	tRNA 3'-trailer cleavage
IT971_22205	COG0071	Belongs to the small heat shock protein (HSP20) family
IT971_22215	COG0519	Catalyzes the synthesis of GMP from XMP
IT971_22215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT971_22235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT971_22260	COG0539	negative regulation of cytoplasmic translation
IT971_22270	COG0616	signal peptide processing
IT971_22275	COG0776	regulation of translation
IT971_22285	COG0284	orotidine-5'-phosphate decarboxylase activity
IT971_22290	COG2814	Major facilitator Superfamily
IT971_22295	COG0730	response to heat
IT971_22300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IT971_22305	COG1024	Enoyl-CoA hydratase
IT971_22310	COG0268	Binds directly to 16S ribosomal RNA