locus-tag	class	description
TH3_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TH3_00010	COG0592	DNA-directed DNA polymerase activity
TH3_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TH3_00020	COG0187	DNA topoisomerase II activity
TH3_00035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TH3_00070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TH3_00080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TH3_00085	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TH3_00115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TH3_00120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TH3_00150	COG1280	lysine exporter protein (LysE YggA)
TH3_00160	COG0137	argininosuccinate synthase activity
TH3_00165	COG0101	tRNA pseudouridine synthase activity
TH3_00175	COG1346	cytolysis
TH3_00185	COG1393	Belongs to the ArsC family
TH3_00195	COG2137	regulation of response to DNA damage stimulus
TH3_00200	COG0842	Transport permease protein
TH3_00205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TH3_00210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TH3_00215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TH3_00235	COG1595	DNA-templated transcription, initiation
TH3_00245	COG0589	response to stress
TH3_00250	COG0659	secondary active sulfate transmembrane transporter activity
TH3_00255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TH3_00260	COG1322	Protein conserved in bacteria
TH3_00265	COG0242	peptide deformylase activity
TH3_00285	COG0583	DNA-binding transcription factor activity
TH3_00315	COG2204	response regulator
TH3_00320	COG4191	Histidine kinase
TH3_00325	COG0745	RESPONSE REGULATOR receiver
TH3_00330	COG0642	Histidine kinase
TH3_00340	COG1660	Displays ATPase and GTPase activities
TH3_00345	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TH3_00345	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TH3_00355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TH3_00360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TH3_00385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TH3_00395	COG1078	dGTPase activity
TH3_00400	COG2205	protein histidine kinase activity
TH3_00435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_00455	COG1802	Transcriptional regulator
TH3_00465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TH3_00475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TH3_00480	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TH3_00485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TH3_00495	COG2816	NAD+ diphosphatase activity
TH3_00510	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
TH3_00515	COG0583	DNA-binding transcription factor activity
TH3_00525	COG0625	glutathione transferase activity
TH3_00535	COG3128	pkhd-type hydroxylase
TH3_00540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TH3_00545	COG2171	N-acyltransferase activity
TH3_00555	COG2200	EAL domain
TH3_00555	COG2199	diguanylate cyclase activity
TH3_00565	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TH3_00580	COG3237	CsbD-like
TH3_00590	COG0512	Glutamine amidotransferase of anthranilate synthase
TH3_00590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TH3_00595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_00610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TH3_00620	COG0840	transmembrane signaling receptor activity
TH3_00630	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TH3_00645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TH3_00655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TH3_00660	COG0745	RESPONSE REGULATOR receiver
TH3_00660	COG3706	GGDEF domain
TH3_00670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TH3_00685	COG2818	Glycosylase
TH3_00690	COG5002	protein histidine kinase activity
TH3_00700	COG0398	Pfam SNARE associated Golgi protein
TH3_00715	COG0302	gtp cyclohydrolase
TH3_00725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TH3_00740	COG0534	Mate efflux family protein
TH3_00745	COG0584	glycerophosphoryl diester phosphodiesterase
TH3_00760	COG1840	ABC-type Fe3 transport system, periplasmic component
TH3_00765	COG4191	Histidine kinase
TH3_00780	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TH3_00785	COG3842	ATPase activity
TH3_00815	COG1205	dead DEAH box helicase
TH3_00815	COG1111	helicase
TH3_00820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TH3_00890	COG4962	Type ii secretion system protein e
TH3_00900	COG2948	multi-organism process
TH3_01000	COG0419	ATPase involved in DNA repair
TH3_01005	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TH3_01010	COG0039	L-malate dehydrogenase activity
TH3_01025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TH3_01035	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TH3_01040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TH3_01045	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TH3_01050	COG3639	organic phosphonate transmembrane transporter activity
TH3_01060	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TH3_01065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TH3_01065	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TH3_01070	COG3454	Phosphonate metabolism
TH3_01075	COG4778	phosphonate C-P lyase system protein PhnL
TH3_01080	COG4107	phosphonate C-P lyase system protein PhnK
TH3_01085	COG3627	carbon phosphorus lyase activity
TH3_01090	COG3626	phosphonate metabolism
TH3_01100	COG3624	Phosphonate C-P lyase system protein PhnG
TH3_01105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TH3_01115	COG5001	Diguanylate cyclase
TH3_01120	COG0024	Methionine aminopeptidase
TH3_01125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TH3_01140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_01155	COG2081	HI0933 family
TH3_01160	COG3706	GGDEF domain
TH3_01190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TH3_01195	COG3806	Anti-sigma factor
TH3_01200	COG1595	DNA-templated transcription, initiation
TH3_01215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TH3_01220	COG2190	(PTS) system
TH3_01220	COG2211	Major facilitator Superfamily
TH3_01235	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_01245	COG0564	pseudouridine synthase activity
TH3_01265	COG1803	Methylglyoxal synthase
TH3_01285	COG0508	dehydrogenase complex catalyzes the overall conversion of
TH3_01295	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TH3_01300	COG0045	succinate-CoA ligase (ADP-forming) activity
TH3_01305	COG0039	L-malate dehydrogenase activity
TH3_01315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TH3_01325	COG1196	nuclear chromosome segregation
TH3_01325	COG3264	Mechanosensitive ion channel
TH3_01330	COG0494	nUDIX hydrolase
TH3_01340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TH3_01360	COG0174	glutamine synthetase
TH3_01370	COG0625	glutathione transferase activity
TH3_01380	COG4974	Belongs to the 'phage' integrase family
TH3_01390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TH3_01415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TH3_01425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TH3_01435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TH3_01440	COG0784	Response regulator, receiver
TH3_01445	COG4235	cytochrome complex assembly
TH3_01450	COG1138	Cytochrome C-type biogenesis protein
TH3_01455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TH3_01460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TH3_01465	COG1702	phosphate starvation-inducible protein PhoH
TH3_01515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_01520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TH3_01540	COG0519	Catalyzes the synthesis of GMP from XMP
TH3_01550	COG1872	DUF167
TH3_01555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TH3_01565	COG0471	metal ion transport
TH3_01565	COG3273	potassium ion transport
TH3_01570	COG3214	Protein conserved in bacteria
TH3_01575	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_01615	COG4774	siderophore transport
TH3_01635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TH3_01640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TH3_01655	COG1595	DNA-templated transcription, initiation
TH3_01670	COG0066	3-isopropylmalate dehydratase activity
TH3_01680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TH3_01700	COG0228	four-way junction DNA binding
TH3_01705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TH3_01720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_01730	COG2217	Heavy metal translocating P-type atpase
TH3_01745	COG2010	Cytochrome c
TH3_01770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TH3_01775	COG0126	phosphoglycerate kinase activity
TH3_01800	COG2267	carboxylic ester hydrolase activity
TH3_01805	COG4106	trans-aconitate 2-methyltransferase activity
TH3_01815	COG1051	belongs to the nudix hydrolase family
TH3_01825	COG0793	Belongs to the peptidase S41A family
TH3_01830	COG4942	peptidase
TH3_01835	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TH3_01840	COG1760	l-serine dehydratase
TH3_01845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TH3_01860	COG0799	negative regulation of ribosome biogenesis
TH3_01865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TH3_01875	COG5265	(ABC) transporter
TH3_01890	COG3706	GGDEF domain
TH3_01895	COG3706	GGDEF domain
TH3_01915	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TH3_01925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TH3_01930	COG0402	S-adenosylhomocysteine deaminase activity
TH3_01940	COG4603	Belongs to the binding-protein-dependent transport system permease family
TH3_01955	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TH3_01965	COG1194	a g-specific adenine glycosylase
TH3_01975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TH3_01975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TH3_01980	COG1196	nuclear chromosome segregation
TH3_02000	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TH3_02005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TH3_02015	COG0435	Glutathione S-transferase
TH3_02020	COG0583	DNA-binding transcription factor activity
TH3_02040	COG0714	Associated with various cellular activities
TH3_02060	COG0617	tRNA 3'-terminal CCA addition
TH3_02075	COG2199	diguanylate cyclase activity
TH3_02075	COG2202	Pas domain
TH3_02075	COG2200	EAL domain
TH3_02080	COG4974	Belongs to the 'phage' integrase family
TH3_02100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TH3_02105	COG4536	flavin adenine dinucleotide binding
TH3_02110	COG0517	IMP dehydrogenase activity
TH3_02135	COG0271	Belongs to the BolA IbaG family
TH3_02155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TH3_02180	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TH3_02195	COG4774	siderophore transport
TH3_02205	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TH3_02210	COG1238	metal cluster binding
TH3_02220	COG1454	alcohol dehydrogenase
TH3_02225	COG1012	belongs to the aldehyde dehydrogenase family
TH3_02230	COG1454	alcohol dehydrogenase
TH3_02235	COG0410	ABC transporter
TH3_02240	COG1129	ABC transporter
TH3_02265	COG2204	response regulator
TH3_02275	COG1063	alcohol dehydrogenase
TH3_02280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_02290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_02295	COG1802	Transcriptional regulator
TH3_02300	COG1312	Catalyzes the dehydration of D-mannonate
TH3_02305	COG0246	Mannitol dehydrogenase
TH3_02325	COG2814	Major facilitator Superfamily
TH3_02335	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TH3_02345	COG3842	ATPase activity
TH3_02360	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TH3_02365	COG1609	Transcriptional regulator
TH3_02370	COG2205	protein histidine kinase activity
TH3_02375	COG0745	RESPONSE REGULATOR receiver
TH3_02380	COG0746	molybdenum cofactor guanylyltransferase activity
TH3_02400	COG1522	sequence-specific DNA binding
TH3_02425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_02440	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TH3_02450	COG0625	glutathione transferase activity
TH3_02470	COG0019	diaminopimelate decarboxylase activity
TH3_02480	COG1309	transcriptional regulator
TH3_02490	COG1609	Transcriptional regulator
TH3_02495	COG1129	ABC transporter
TH3_02500	COG1172	Belongs to the binding-protein-dependent transport system permease family
TH3_02505	COG1879	ABC-type sugar transport system periplasmic component
TH3_02515	COG0673	inositol 2-dehydrogenase activity
TH3_02530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_02545	COG0154	amidase activity
TH3_02580	COG1522	sequence-specific DNA binding
TH3_02585	COG3608	succinylglutamate desuccinylase aspartoacylase
TH3_02590	COG0006	proline dipeptidase activity
TH3_02595	COG2423	ornithine cyclodeaminase activity
TH3_02600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TH3_02610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_02615	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TH3_02620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TH3_02625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_02630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_02635	COG1012	belongs to the aldehyde dehydrogenase family
TH3_02650	COG1234	tRNA 3'-trailer cleavage
TH3_02670	COG1733	regulation of RNA biosynthetic process
TH3_02685	COG3706	GGDEF domain
TH3_02685	COG0745	RESPONSE REGULATOR receiver
TH3_02700	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TH3_02725	COG3706	GGDEF domain
TH3_02730	COG0321	lipoyl(octanoyl) transferase activity
TH3_02735	COG0281	malic enzyme
TH3_02735	COG0280	phosphate acetyltransferase
TH3_02740	COG2239	Acts as a magnesium transporter
TH3_02770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TH3_02810	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_02840	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TH3_02850	COG2274	protein secretion by the type I secretion system
TH3_02855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_02865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TH3_02875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TH3_02880	COG0706	membrane insertase activity
TH3_02885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TH3_02890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TH3_02895	COG3706	GGDEF domain
TH3_02900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TH3_02905	COG0552	protein localization to endoplasmic reticulum
TH3_02915	COG0783	Belongs to the Dps family
TH3_02945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TH3_02980	COG0742	ribosomal rna small subunit methyltransferase
TH3_02985	COG1187	pseudouridine synthase activity
TH3_02990	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TH3_02995	COG0590	tRNA wobble adenosine to inosine editing
TH3_03000	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TH3_03005	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TH3_03015	COG4221	oxidoreductase activity
TH3_03020	COG2207	Transcriptional regulator
TH3_03030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TH3_03035	COG1120	ATPase activity
TH3_03040	COG0151	Belongs to the GarS family
TH3_03045	COG1570	exodeoxyribonuclease VII activity
TH3_03055	COG0405	Gamma-glutamyltransferase
TH3_03070	COG1560	Kdo2-lipid A biosynthetic process
TH3_03075	COG1663	tetraacyldisaccharide 4'-kinase activity
TH3_03080	COG1519	Transferase
TH3_03090	COG1132	(ABC) transporter
TH3_03100	COG0438	transferase activity, transferring glycosyl groups
TH3_03110	COG1597	lipid kinase activity
TH3_03115	COG0312	modulator of DNA gyrase
TH3_03135	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TH3_03160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TH3_03190	COG3639	organic phosphonate transmembrane transporter activity
TH3_03205	COG1349	DNA-binding transcription factor activity
TH3_03210	COG0114	fumarate hydratase activity
TH3_03235	COG1280	lysine exporter protein (LysE YggA)
TH3_03255	COG4608	Belongs to the ABC transporter superfamily
TH3_03260	COG0444	Belongs to the ABC transporter superfamily
TH3_03265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_03270	COG0601	transmembrane transport
TH3_03275	COG0747	negative chemotaxis
TH3_03305	COG0312	modulator of DNA gyrase
TH3_03320	COG1612	heme a metabolic process
TH3_03330	COG0175	sulfate reduction
TH3_03375	COG2373	Large extracellular alpha-helical protein
TH3_03380	COG4953	penicillin-binding protein 1C
TH3_03385	COG1522	sequence-specific DNA binding
TH3_03390	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TH3_03410	COG3265	gluconokinase activity
TH3_03415	COG1609	Transcriptional regulator
TH3_03420	COG1739	Uncharacterized protein family UPF0029
TH3_03440	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TH3_03455	COG0393	Putative heavy-metal-binding
TH3_03460	COG0393	Putative heavy-metal-binding
TH3_03470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TH3_03485	COG0789	Transcriptional regulator
TH3_03515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TH3_03525	COG0010	Belongs to the arginase family
TH3_03535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_03550	COG0840	transmembrane signaling receptor activity
TH3_03555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TH3_03565	COG0668	transmembrane transport
TH3_03570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TH3_03575	COG2962	Rard protein
TH3_03595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TH3_03620	COG0643	Histidine kinase
TH3_03620	COG2198	Histidine kinase
TH3_03645	COG0745	RESPONSE REGULATOR receiver
TH3_03650	COG1157	protein secretion by the type III secretion system
TH3_03660	COG0442	prolyl-tRNA aminoacylation
TH3_03665	COG0861	Integral membrane protein TerC family
TH3_03670	COG4134	Bacterial extracellular solute-binding protein
TH3_03675	COG4135	transport system, permease component
TH3_03680	COG4136	ATPase activity
TH3_03685	COG3128	pkhd-type hydroxylase
TH3_03695	COG0251	oxidation-reduction process
TH3_03710	COG0489	protein tyrosine kinase activity
TH3_03720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TH3_03725	COG2204	response regulator
TH3_03730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TH3_03735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TH3_03745	COG1766	The M ring may be actively involved in energy transduction
TH3_03750	COG1749	Flagellar hook protein flgE
TH3_03755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TH3_03770	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TH3_03780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TH3_03785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TH3_03800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TH3_03815	COG1256	bacterial-type flagellum assembly
TH3_03825	COG3951	Flagellar rod assembly protein muramidase FlgJ
TH3_03830	COG1706	bacterial-type flagellum-dependent cell motility
TH3_03840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TH3_03845	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TH3_03855	COG4786	Flagellar basal body rod
TH3_03860	COG4786	Flagellar basal body rod
TH3_03885	COG0745	RESPONSE REGULATOR receiver
TH3_03925	COG1338	Plays a role in the flagellum-specific transport system
TH3_03940	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TH3_03945	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TH3_03950	COG1815	bacterial-type flagellum-dependent cell motility
TH3_03955	COG1558	bacterial-type flagellum-dependent cell motility
TH3_03960	COG1677	Flagellar hook-basal body complex protein FliE
TH3_03965	COG1987	bacterial-type flagellum assembly
TH3_03970	COG1684	flagellar biosynthetic protein fliR
TH3_03975	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TH3_04045	COG5487	UPF0391 membrane protein
TH3_04070	COG4325	translation initiation factor activity
TH3_04100	COG0542	response to heat
TH3_04120	COG4187	Peptidase family M20/M25/M40
TH3_04125	COG0584	glycerophosphoryl diester phosphodiesterase
TH3_04130	COG0655	NAD(P)H dehydrogenase (quinone) activity
TH3_04160	COG1595	DNA-templated transcription, initiation
TH3_04170	COG0538	isocitrate dehydrogenase activity
TH3_04210	COG0395	ABC-type sugar transport system, permease component
TH3_04220	COG1653	transport
TH3_04225	COG3842	ATPase activity
TH3_04230	COG1349	DNA-binding transcription factor activity
TH3_04235	COG0492	ferredoxin-NADP+ reductase activity
TH3_04255	COG1611	Belongs to the LOG family
TH3_04270	COG0688	phosphatidylethanolamine metabolic process
TH3_04330	COG0602	queuosine metabolic process
TH3_04335	COG0720	synthase
TH3_04340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TH3_04345	COG2226	methyltransferase
TH3_04360	COG2032	superoxide dismutase activity
TH3_04375	COG0495	leucyl-tRNA aminoacylation
TH3_04395	COG0438	transferase activity, transferring glycosyl groups
TH3_04430	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TH3_04465	COG1643	Atp-dependent helicase
TH3_04505	COG2084	Dehydrogenase
TH3_04545	COG3247	response to pH
TH3_04550	COG1819	glycosyl
TH3_04555	COG1199	ATP-dependent helicase activity
TH3_04580	COG1238	metal cluster binding
TH3_04590	COG1764	response to oxidative stress
TH3_04600	COG1846	Transcriptional regulator
TH3_04630	COG4191	Histidine kinase
TH3_04635	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TH3_04640	COG0506	proline dehydrogenase activity
TH3_04650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TH3_04655	COG1609	Transcriptional regulator
TH3_04660	COG1840	ABC-type Fe3 transport system, periplasmic component
TH3_04670	COG3842	ATPase activity
TH3_04675	COG0483	inositol monophosphate 1-phosphatase activity
TH3_04690	COG3422	double-strand break repair
TH3_04730	COG2963	transposase activity
TH3_04940	COG0167	dihydroorotate dehydrogenase activity
TH3_04965	COG0697	spore germination
TH3_04970	COG0747	negative chemotaxis
TH3_04975	COG0601	transmembrane transport
TH3_04980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_04985	COG4172	Belongs to the ABC transporter superfamily
TH3_04990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TH3_04995	COG2162	N-hydroxyarylamine O-acetyltransferase activity
TH3_05030	COG1595	DNA-templated transcription, initiation
TH3_05040	COG4774	siderophore transport
TH3_05050	COG0500	methyltransferase
TH3_05060	COG4120	Belongs to the binding-protein-dependent transport system permease family
TH3_05085	COG1309	transcriptional regulator
TH3_05090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_05095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TH3_05115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TH3_05135	COG2391	methyltransferase activity
TH3_05140	COG0513	Belongs to the DEAD box helicase family
TH3_05145	COG1278	Cold shock
TH3_05150	COG2186	Transcriptional regulator
TH3_05160	COG0765	amino acid transport
TH3_05180	COG1671	Belongs to the UPF0178 family
TH3_05200	COG2130	NADP-dependent
TH3_05210	COG0840	transmembrane signaling receptor activity
TH3_05215	COG0523	cobalamin synthesis protein
TH3_05220	COG0625	glutathione transferase activity
TH3_05225	COG0625	glutathione transferase activity
TH3_05230	COG0477	Major facilitator Superfamily
TH3_05235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TH3_05240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TH3_05245	COG1845	cytochrome c oxidase, subunit III
TH3_05250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TH3_05255	COG3346	SURF1 family
TH3_05265	COG2226	methyltransferase
TH3_05270	COG1309	transcriptional regulator
TH3_05275	COG1970	mechanosensitive ion channel activity
TH3_05285	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TH3_05295	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TH3_05295	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TH3_05310	COG3180	Ammonia monooxygenase
TH3_05315	COG1335	isochorismatase
TH3_05335	COG2378	regulation of single-species biofilm formation
TH3_05345	COG5001	Diguanylate cyclase
TH3_05345	COG3300	MHYT domain
TH3_05355	COG3706	GGDEF domain
TH3_05355	COG0745	RESPONSE REGULATOR receiver
TH3_05360	COG1366	Belongs to the anti-sigma-factor antagonist family
TH3_05365	COG2204	response regulator
TH3_05380	COG5002	protein histidine kinase activity
TH3_05380	COG0784	Response regulator, receiver
TH3_05395	COG0584	glycerophosphoryl diester phosphodiesterase
TH3_05400	COG1879	ABC-type sugar transport system periplasmic component
TH3_05405	COG0745	RESPONSE REGULATOR receiver
TH3_05405	COG3706	GGDEF domain
TH3_05410	COG0772	Belongs to the SEDS family
TH3_05415	COG0768	penicillin binding
TH3_05440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TH3_05445	COG1280	lysine exporter protein (LysE YggA)
TH3_05460	COG3706	GGDEF domain
TH3_05465	COG1278	Cold shock
TH3_05470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TH3_05485	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TH3_05490	COG0840	transmembrane signaling receptor activity
TH3_05505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TH3_05505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TH3_05515	COG0519	Catalyzes the synthesis of GMP from XMP
TH3_05520	COG2824	Alkylphosphonate utilization operon protein PhnA
TH3_05530	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_05535	COG3655	Transcriptional regulator
TH3_05555	COG0640	Transcriptional regulator
TH3_05585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TH3_05590	COG0765	amino acid transport
TH3_05595	COG0765	amino acid transport
TH3_05650	COG1653	transport
TH3_05660	COG0395	ABC-type sugar transport system, permease component
TH3_05675	COG1012	belongs to the aldehyde dehydrogenase family
TH3_05680	COG0596	Alpha beta hydrolase
TH3_05685	COG0494	nUDIX hydrolase
TH3_05710	COG1653	transport
TH3_05725	COG0366	Alpha amylase catalytic
TH3_05730	COG3842	ATPase activity
TH3_05735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TH3_05740	COG0363	glucosamine-6-phosphate deaminase activity
TH3_05745	COG0129	dihydroxy-acid dehydratase activity
TH3_05750	COG0837	glucose binding
TH3_05755	COG0800	Aldolase
TH3_05780	COG1595	DNA-templated transcription, initiation
TH3_05805	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
TH3_05830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_05840	COG2719	SpoVR family
TH3_05845	COG2718	Belongs to the UPF0229 family
TH3_05850	COG2766	serine protein kinase
TH3_05855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TH3_05890	COG0251	oxidation-reduction process
TH3_05895	COG0251	oxidation-reduction process
TH3_05900	COG1309	transcriptional regulator
TH3_05915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TH3_05920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TH3_05925	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TH3_05935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TH3_05945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TH3_05955	COG0222	ribosome binding
TH3_05960	COG0085	RNA polymerase activity
TH3_05965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TH3_05980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TH3_05985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TH3_05995	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TH3_06000	COG0088	Forms part of the polypeptide exit tunnel
TH3_06005	COG0089	rRNA binding
TH3_06015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TH3_06025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TH3_06030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TH3_06035	COG0255	Belongs to the universal ribosomal protein uL29 family
TH3_06045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TH3_06050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TH3_06055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TH3_06065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TH3_06070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TH3_06075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TH3_06085	COG1841	ribosomal large subunit assembly
TH3_06095	COG0201	protein transport
TH3_06100	COG0563	adenylate kinase activity
TH3_06105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TH3_06110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TH3_06120	COG0203	ribosomal protein L17
TH3_06125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TH3_06140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TH3_06145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TH3_06155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TH3_06160	COG0564	pseudouridine synthase activity
TH3_06170	COG0546	phosphoglycolate phosphatase activity
TH3_06185	COG0412	Dienelactone hydrolase
TH3_06190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_06215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TH3_06225	COG0840	transmembrane signaling receptor activity
TH3_06245	COG1254	Belongs to the acylphosphatase family
TH3_06260	COG0277	FAD linked oxidase domain protein
TH3_06265	COG0009	L-threonylcarbamoyladenylate synthase
TH3_06300	COG1355	regulation of microtubule-based process
TH3_06310	COG0456	acetyltransferase
TH3_06320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TH3_06345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TH3_06350	COG2011	ABC-type metal ion transport system permease component
TH3_06375	COG0477	Major facilitator Superfamily
TH3_06405	COG0798	PFAM Bile acid sodium symporter
TH3_06415	COG0431	NADPH-dependent FMN reductase
TH3_06435	COG0488	(ABC) transporter
TH3_06440	COG0105	UTP biosynthetic process
TH3_06460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TH3_06465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TH3_06475	COG0628	permease
TH3_06480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TH3_06485	COG0189	ligase activity
TH3_06485	COG4067	protein conserved in archaea
TH3_06490	COG0189	ligase activity
TH3_06500	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TH3_06510	COG0702	epimerase
TH3_06515	COG0583	DNA-binding transcription factor activity
TH3_06525	COG0248	Ppx GppA phosphatase
TH3_06530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TH3_06555	COG0640	Transcriptional regulator
TH3_06560	COG0123	including yeast histone deacetylase and acetoin utilization protein
TH3_06580	COG0142	geranyltranstransferase activity
TH3_06590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TH3_06615	COG0318	PFAM AMP-dependent synthetase and ligase
TH3_06640	COG1802	Transcriptional regulator
TH3_06645	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TH3_06655	COG0583	DNA-binding transcription factor activity
TH3_06685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TH3_06690	COG1295	ribonuclease BN
TH3_06700	COG0300	oxidoreductase activity
TH3_06705	COG0318	PFAM AMP-dependent synthetase and ligase
TH3_06715	COG3264	Mechanosensitive ion channel
TH3_06715	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
TH3_06735	COG0484	heat shock protein binding
TH3_06750	COG0640	Transcriptional regulator
TH3_06765	COG2135	peptidase activity
TH3_06770	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_06775	COG3153	acetyltransferase
TH3_06785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TH3_06795	COG0156	8-amino-7-oxononanoate synthase activity
TH3_06800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_06835	COG2249	NAD(P)H dehydrogenase (quinone) activity
TH3_06840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TH3_06850	COG0659	secondary active sulfate transmembrane transporter activity
TH3_06855	COG1250	3-hydroxyacyl-CoA dehydrogenase
TH3_06855	COG1024	Enoyl-CoA hydratase
TH3_06860	COG2814	Major facilitator Superfamily
TH3_06865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_06870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TH3_06885	COG4191	Histidine kinase
TH3_06895	COG0583	DNA-binding transcription factor activity
TH3_06900	COG2814	Major facilitator Superfamily
TH3_06910	COG0656	L-ascorbic acid biosynthetic process
TH3_06935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TH3_06945	COG1252	NADH dehydrogenase
TH3_06950	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TH3_06955	COG0583	DNA-binding transcription factor activity
TH3_06960	COG3622	Belongs to the hyi family
TH3_06975	COG2186	Transcriptional regulator
TH3_06985	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TH3_07005	COG0840	transmembrane signaling receptor activity
TH3_07035	COG3135	benzoate transporter
TH3_07065	COG0483	inositol monophosphate 1-phosphatase activity
TH3_07070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TH3_07075	COG0352	thiamine-phosphate diphosphorylase activity
TH3_07100	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TH3_07105	COG1692	metallophosphoesterase
TH3_07120	COG0217	transcriptional regulatory protein
TH3_07130	COG0632	four-way junction helicase activity
TH3_07135	COG2255	four-way junction helicase activity
TH3_07140	COG0824	Thioesterase
TH3_07150	COG0848	biopolymer transport protein
TH3_07165	COG2885	chlorophyll binding
TH3_07185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TH3_07190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TH3_07215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TH3_07220	COG0352	thiamine-phosphate diphosphorylase activity
TH3_07220	COG0351	phosphomethylpyrimidine kinase
TH3_07235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TH3_07245	COG0129	dihydroxy-acid dehydratase activity
TH3_07255	COG1473	amidohydrolase
TH3_07260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_07270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_07275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TH3_07280	COG0583	DNA-binding transcription factor activity
TH3_07285	COG0686	Belongs to the AlaDH PNT family
TH3_07290	COG1522	sequence-specific DNA binding
TH3_07315	COG1177	transmembrane transport
TH3_07320	COG1176	ABC-type spermidine putrescine transport system, permease component I
TH3_07325	COG3842	ATPase activity
TH3_07335	COG0174	glutamine synthetase
TH3_07345	COG4948	Mandelate Racemase Muconate Lactonizing
TH3_07350	COG0745	RESPONSE REGULATOR receiver
TH3_07350	COG3706	GGDEF domain
TH3_07370	COG4095	Psort location CytoplasmicMembrane, score
TH3_07375	COG0842	Transport permease protein
TH3_07380	COG1129	ABC transporter
TH3_07380	COG0842	Transport permease protein
TH3_07385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_07395	COG2199	diguanylate cyclase activity
TH3_07395	COG2200	EAL domain
TH3_07395	COG2202	Pas domain
TH3_07410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TH3_07415	COG0583	DNA-binding transcription factor activity
TH3_07430	COG0277	FAD linked oxidase domain protein
TH3_07430	COG0247	lactate metabolic process
TH3_07435	COG1116	anion transmembrane transporter activity
TH3_07440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_07445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TH3_07555	COG1840	ABC-type Fe3 transport system, periplasmic component
TH3_07570	COG3842	ATPase activity
TH3_07575	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TH3_07580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TH3_07585	COG2076	Multidrug Resistance protein
TH3_07590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TH3_07615	COG2194	sulfuric ester hydrolase activity
TH3_07620	COG1309	transcriptional regulator
TH3_07625	COG0432	Pfam Uncharacterised protein family UPF0047
TH3_07640	COG2132	Multicopper oxidase
TH3_07670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TH3_07690	COG4765	Protein conserved in bacteria
TH3_07695	COG2353	YceI-like domain
TH3_07700	COG3038	cytochrome b561
TH3_07705	COG2353	YceI-like domain
TH3_07715	COG0840	transmembrane signaling receptor activity
TH3_07720	COG0400	carboxylic ester hydrolase activity
TH3_07725	COG0534	Mate efflux family protein
TH3_07730	COG1522	sequence-specific DNA binding
TH3_07740	COG1959	2 iron, 2 sulfur cluster binding
TH3_07745	COG0513	Belongs to the DEAD box helicase family
TH3_07775	COG2066	Belongs to the glutaminase family
TH3_07780	COG0187	DNA topoisomerase II activity
TH3_07785	COG1607	acyl-coa hydrolase
TH3_07800	COG4221	oxidoreductase activity
TH3_07815	COG4608	Belongs to the ABC transporter superfamily
TH3_07820	COG0444	Belongs to the ABC transporter superfamily
TH3_07830	COG0601	transmembrane transport
TH3_07835	COG0747	negative chemotaxis
TH3_07860	COG0469	pyruvate kinase activity
TH3_07880	COG0693	protein deglycase activity
TH3_07885	COG0668	transmembrane transport
TH3_07900	COG1832	CoA-binding protein
TH3_07940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TH3_07945	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TH3_07955	COG1304	FMN binding
TH3_07975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TH3_07990	COG0697	spore germination
TH3_08000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TH3_08010	COG1858	cytochrome C peroxidase
TH3_08015	COG2084	Dehydrogenase
TH3_08020	COG3243	poly(R)-hydroxyalkanoic acid synthase
TH3_08030	COG2885	chlorophyll binding
TH3_08035	COG0436	Aminotransferase
TH3_08045	COG1494	fructose-1,6-bisphosphatase
TH3_08050	COG0443	Heat shock 70 kDa protein
TH3_08065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TH3_08065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TH3_08080	COG2223	nitrite transmembrane transporter activity
TH3_08085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TH3_08105	COG1234	tRNA 3'-trailer cleavage
TH3_08120	COG0840	transmembrane signaling receptor activity
TH3_08135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TH3_08160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_08170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TH3_08175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_08180	COG1116	anion transmembrane transporter activity
TH3_08190	COG2831	hemolysin activation secretion protein
TH3_08250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TH3_08255	COG0372	Belongs to the citrate synthase family
TH3_08280	COG0123	including yeast histone deacetylase and acetoin utilization protein
TH3_08320	COG0523	cobalamin synthesis protein
TH3_08340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TH3_08350	COG0626	cystathionine gamma-synthase activity
TH3_08360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TH3_08375	COG2897	thiosulfate sulfurtransferase activity
TH3_08380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TH3_08425	COG1620	l-lactate permease
TH3_08430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TH3_08440	COG0583	DNA-binding transcription factor activity
TH3_08445	COG2814	Major facilitator Superfamily
TH3_08455	COG0494	nUDIX hydrolase
TH3_08460	COG3706	GGDEF domain
TH3_08465	COG1247	-acetyltransferase
TH3_08470	COG2195	Cleaves the N-terminal amino acid of tripeptides
TH3_08475	COG0484	heat shock protein binding
TH3_08525	COG0730	response to heat
TH3_08530	COG0425	Belongs to the sulfur carrier protein TusA family
TH3_08535	COG2153	protein acetylation
TH3_08570	COG1067	ATP-dependent peptidase activity
TH3_08575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TH3_08590	COG0156	8-amino-7-oxononanoate synthase activity
TH3_08600	COG3273	potassium ion transport
TH3_08600	COG0471	metal ion transport
TH3_08630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TH3_08635	COG0564	pseudouridine synthase activity
TH3_08655	COG1846	Transcriptional regulator
TH3_08725	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TH3_08735	COG3448	diguanylate cyclase activity
TH3_08735	COG4175	Glycine betaine
TH3_08740	COG4176	ABC-type proline glycine betaine transport system permease component
TH3_08745	COG2113	Glycine betaine
TH3_08750	COG4176	ABC-type proline glycine betaine transport system permease component
TH3_08755	COG4175	Glycine betaine
TH3_08775	COG1840	ABC-type Fe3 transport system, periplasmic component
TH3_08780	COG1840	ABC-type Fe3 transport system, periplasmic component
TH3_08790	COG0303	'Molybdopterin
TH3_08795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TH3_08805	COG0438	transferase activity, transferring glycosyl groups
TH3_08840	COG0747	negative chemotaxis
TH3_08845	COG0601	transmembrane transport
TH3_08850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_08855	COG2814	Major facilitator Superfamily
TH3_08865	COG2814	Major facilitator Superfamily
TH3_08870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_08870	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TH3_08875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TH3_08880	COG1393	Belongs to the ArsC family
TH3_08885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TH3_08890	COG0405	Gamma-glutamyltransferase
TH3_08910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TH3_08915	COG0793	Belongs to the peptidase S41A family
TH3_08930	COG0557	exoribonuclease II activity
TH3_08935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TH3_08940	COG0758	DNA mediated transformation
TH3_08945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TH3_08950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TH3_08975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TH3_08985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TH3_08995	COG0840	transmembrane signaling receptor activity
TH3_09005	COG2223	nitrite transmembrane transporter activity
TH3_09020	COG0583	DNA-binding transcription factor activity
TH3_09025	COG1435	thymidine kinase activity
TH3_09040	COG2995	paraquat-inducible protein a
TH3_09045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TH3_09045	COG3008	intermembrane lipid transfer
TH3_09060	COG4977	sequence-specific DNA binding
TH3_09065	COG2814	Major facilitator Superfamily
TH3_09105	COG0174	glutamine synthetase
TH3_09110	COG1012	belongs to the aldehyde dehydrogenase family
TH3_09115	COG1454	alcohol dehydrogenase
TH3_09120	COG0519	Catalyzes the synthesis of GMP from XMP
TH3_09120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TH3_09125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TH3_09130	COG0737	Belongs to the 5'-nucleotidase family
TH3_09170	COG0295	cytidine deaminase activity
TH3_09175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TH3_09180	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TH3_09190	COG0471	metal ion transport
TH3_09200	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TH3_09215	COG1126	abc transporter atp-binding protein
TH3_09220	COG0765	amino acid transport
TH3_09225	COG4597	amino acid ABC transporter
TH3_09230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TH3_09235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TH3_09240	COG0521	Mo-molybdopterin cofactor biosynthetic process
TH3_09250	COG0840	transmembrane signaling receptor activity
TH3_09265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TH3_09295	COG2814	Major facilitator Superfamily
TH3_09320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TH3_09330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TH3_09340	COG1122	ATPase activity
TH3_09355	COG0310	cobalt ion transport
TH3_09385	COG1042	CoA-binding domain protein
TH3_09385	COG0045	succinate-CoA ligase (ADP-forming) activity
TH3_09385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TH3_09395	COG4989	oxidoreductase activity
TH3_09400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TH3_09405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TH3_09410	COG1538	Outer membrane efflux protein
TH3_09420	COG0525	valine-tRNA ligase activity
TH3_09430	COG0512	Glutamine amidotransferase of anthranilate synthase
TH3_09450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TH3_09460	COG0316	Belongs to the HesB IscA family
TH3_09475	COG1472	Belongs to the glycosyl hydrolase 3 family
TH3_09480	COG1994	Peptidase M50
TH3_09485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TH3_09490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TH3_09495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TH3_09500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TH3_09505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TH3_09510	COG0805	protein transport
TH3_09530	COG4942	peptidase
TH3_09545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TH3_09560	COG3737	Protein of unknown function (DUF498/DUF598)
TH3_09565	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TH3_09570	COG0668	transmembrane transport
TH3_09595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TH3_09600	COG0191	fructose-bisphosphate aldolase activity
TH3_09610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TH3_09615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TH3_09625	COG2971	BadF BadG BcrA BcrD
TH3_09630	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TH3_09640	COG1175	transmembrane transport
TH3_09650	COG3842	ATPase activity
TH3_09660	COG3842	ATPase activity
TH3_09665	COG1176	ABC-type spermidine putrescine transport system, permease component I
TH3_09670	COG1177	transmembrane transport
TH3_09685	COG0395	ABC-type sugar transport system, permease component
TH3_09690	COG3842	ATPase activity
TH3_09695	COG1956	GAF domain-containing protein
TH3_09700	COG0629	single-stranded DNA binding
TH3_09720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TH3_09740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TH3_09745	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TH3_09750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TH3_09760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TH3_09800	COG2951	lytic endotransglycosylase activity
TH3_09810	COG1686	Belongs to the peptidase S11 family
TH3_09815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TH3_09830	COG0084	hydrolase, TatD family'
TH3_09835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TH3_09835	COG0321	lipoyl(octanoyl) transferase activity
TH3_09840	COG1846	Transcriptional regulator
TH3_09850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TH3_09855	COG1917	Cupin 2, conserved barrel domain protein
TH3_09860	COG0527	aspartate kinase activity
TH3_09865	COG3956	TIGRFAM MazG family protein
TH3_09870	COG0483	inositol monophosphate 1-phosphatase activity
TH3_09875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TH3_09890	COG0569	domain protein
TH3_09895	COG2204	response regulator
TH3_09935	COG1324	tolerance protein
TH3_09955	COG0776	regulation of translation
TH3_09965	COG0416	fatty acid biosynthetic process
TH3_09985	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TH3_09990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TH3_09995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TH3_10000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TH3_10000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TH3_10010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TH3_10010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TH3_10015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TH3_10025	COG0698	ribose 5-phosphate isomerase
TH3_10050	COG0411	ABC transporter
TH3_10075	COG1024	Enoyl-CoA hydratase
TH3_10100	COG0113	porphobilinogen synthase activity
TH3_10120	COG0318	PFAM AMP-dependent synthetase and ligase
TH3_10130	COG1012	belongs to the aldehyde dehydrogenase family
TH3_10135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TH3_10140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TH3_10145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TH3_10150	COG1360	Flagellar Motor Protein
TH3_10160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_10165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_10175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TH3_10180	COG1381	Involved in DNA repair and RecF pathway recombination
TH3_10195	COG0571	ribonuclease III activity
TH3_10200	COG0681	Belongs to the peptidase S26 family
TH3_10205	COG0736	holo-[acyl-carrier-protein] synthase activity
TH3_10210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TH3_10240	COG1573	uracil-dna glycosylase
TH3_10245	COG0514	ATP-dependent DNA helicase (RecQ)
TH3_10250	COG0386	Belongs to the glutathione peroxidase family
TH3_10255	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TH3_10260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TH3_10265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TH3_10270	COG1196	nuclear chromosome segregation
TH3_10270	COG0741	lytic transglycosylase activity
TH3_10270	COG0739	heme binding
TH3_10285	COG0739	heme binding
TH3_10290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TH3_10295	COG1546	Belongs to the CinA family
TH3_10295	COG1058	Belongs to the CinA family
TH3_10300	COG2867	negative regulation of translational initiation
TH3_10305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TH3_10310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TH3_10315	COG0508	dehydrogenase complex catalyzes the overall conversion of
TH3_10320	COG0022	dehydrogenase e1 component
TH3_10320	COG0508	dehydrogenase complex catalyzes the overall conversion of
TH3_10325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TH3_10330	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TH3_10335	COG0148	phosphopyruvate hydratase activity
TH3_10355	COG0149	triose-phosphate isomerase activity
TH3_10360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TH3_10365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TH3_10380	COG0443	Heat shock 70 kDa protein
TH3_10385	COG0443	Heat shock 70 kDa protein
TH3_10390	COG2861	carbohydrate metabolic process
TH3_10410	COG0315	cyclic pyranopterin monophosphate synthase activity
TH3_10420	COG0658	competence protein
TH3_10420	COG2333	competence protein COMEC
TH3_10425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TH3_10430	COG0372	Belongs to the citrate synthase family
TH3_10440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TH3_10445	COG3494	Protein of unknown function (DUF1009)
TH3_10460	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TH3_10475	COG0750	zinc metalloprotease
TH3_10480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TH3_10485	COG0575	Belongs to the CDS family
TH3_10490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TH3_10500	COG0528	UMP kinase activity
TH3_10505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TH3_10520	COG0587	DNA-directed DNA polymerase activity
TH3_10535	COG0442	prolyl-tRNA aminoacylation
TH3_10585	COG0713	ATP synthesis coupled electron transport
TH3_10595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TH3_10600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TH3_10605	COG1034	ATP synthesis coupled electron transport
TH3_10610	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TH3_10615	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TH3_10630	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TH3_10635	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TH3_10640	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TH3_10675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TH3_10675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TH3_10685	COG2205	protein histidine kinase activity
TH3_10685	COG2202	Pas domain
TH3_10700	COG2217	Heavy metal translocating P-type atpase
TH3_10705	COG2193	ferroxidase activity
TH3_10715	COG3046	protein related to deoxyribodipyrimidine photolyase
TH3_10740	COG0395	ABC-type sugar transport system, permease component
TH3_10745	COG3842	ATPase activity
TH3_10755	COG0745	RESPONSE REGULATOR receiver
TH3_10765	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TH3_10770	COG0166	Belongs to the GPI family
TH3_10785	COG0010	Belongs to the arginase family
TH3_10790	COG1012	belongs to the aldehyde dehydrogenase family
TH3_10795	COG1917	Cupin 2, conserved barrel domain protein
TH3_10795	COG1396	sequence-specific DNA binding
TH3_10800	COG0174	glutamine synthetase
TH3_10810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_10825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_10835	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TH3_10840	COG1012	belongs to the aldehyde dehydrogenase family
TH3_10855	COG4176	ABC-type proline glycine betaine transport system permease component
TH3_10870	COG0583	DNA-binding transcription factor activity
TH3_10880	COG1177	transmembrane transport
TH3_10890	COG3842	ATPase activity
TH3_10895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_10900	COG3246	L-lysine catabolic process to acetate
TH3_10915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TH3_10920	COG0251	oxidation-reduction process
TH3_10940	COG2423	ornithine cyclodeaminase activity
TH3_10965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_10970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_10985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TH3_10995	COG0729	surface antigen
TH3_11000	COG0189	ligase activity
TH3_11045	COG0183	Belongs to the thiolase family
TH3_11050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TH3_11055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TH3_11060	COG3485	protocatechuate 3,4-dioxygenase
TH3_11065	COG3485	protocatechuate 3,4-dioxygenase
TH3_11070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TH3_11075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TH3_11080	COG0583	DNA-binding transcription factor activity
TH3_11110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_11145	COG2814	Major facilitator Superfamily
TH3_11155	COG2375	cellular response to nickel ion
TH3_11210	COG3769	mannosylglycerate metabolic process
TH3_11215	COG1215	transferase activity, transferring glycosyl groups
TH3_11235	COG0366	Alpha amylase catalytic
TH3_11245	COG0583	DNA-binding transcription factor activity
TH3_11265	COG1414	Transcriptional regulator
TH3_11275	COG1247	-acetyltransferase
TH3_11295	COG1741	Belongs to the pirin family
TH3_11300	COG2337	Toxic component of a toxin-antitoxin (TA) module
TH3_11340	COG2186	Transcriptional regulator
TH3_11350	COG1172	Belongs to the binding-protein-dependent transport system permease family
TH3_11355	COG1172	Belongs to the binding-protein-dependent transport system permease family
TH3_11360	COG1129	ABC transporter
TH3_11365	COG1879	ABC-type sugar transport system periplasmic component
TH3_11370	COG2017	converts alpha-aldose to the beta-anomer
TH3_11385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_11390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_11395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_11400	COG1802	Transcriptional regulator
TH3_11415	COG3220	belongs to the UPF0276 family
TH3_11440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TH3_11460	COG0308	aminopeptidase N
TH3_11475	COG0628	permease
TH3_11480	COG1917	Cupin 2, conserved barrel domain protein
TH3_11480	COG2207	Transcriptional regulator
TH3_11485	COG1280	lysine exporter protein (LysE YggA)
TH3_11500	COG2205	protein histidine kinase activity
TH3_11510	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_11515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_11535	COG4977	sequence-specific DNA binding
TH3_11565	COG0848	biopolymer transport protein
TH3_11570	COG0848	biopolymer transport protein
TH3_11575	COG0811	peptide transport
TH3_11580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TH3_11585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TH3_11590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TH3_11595	COG0697	spore germination
TH3_11615	COG0418	dihydroorotase activity
TH3_11630	COG0436	Aminotransferase
TH3_11645	COG3706	GGDEF domain
TH3_11655	COG1765	OsmC-like protein
TH3_11680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TH3_11695	COG1802	Transcriptional regulator
TH3_11700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_11710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_11715	COG5001	Diguanylate cyclase
TH3_11715	COG5002	protein histidine kinase activity
TH3_11730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TH3_11740	COG0583	DNA-binding transcription factor activity
TH3_11755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TH3_11790	COG0482	sulfurtransferase activity
TH3_11795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TH3_11800	COG2975	iron-sulfur cluster assembly
TH3_11805	COG0633	Ferredoxin
TH3_11820	COG0316	Belongs to the HesB IscA family
TH3_11825	COG0822	iron-sulfur transferase activity
TH3_11830	COG1104	cysteine desulfurase activity
TH3_11835	COG1104	cysteine desulfurase activity
TH3_11840	COG1959	2 iron, 2 sulfur cluster binding
TH3_11845	COG1045	serine acetyltransferase
TH3_11850	COG2945	thiolester hydrolase activity
TH3_11860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TH3_11875	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TH3_11880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TH3_11890	COG2833	Protein of unknown function (DUF455)
TH3_11900	COG0625	glutathione transferase activity
TH3_11935	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TH3_11940	COG0860	N-Acetylmuramoyl-L-alanine amidase
TH3_11950	COG1530	ribonuclease E activity
TH3_11965	COG0501	Belongs to the peptidase M48B family
TH3_11990	COG0511	ligase activity, forming carbon-carbon bonds
TH3_11995	COG0439	Biotin carboxylase
TH3_12000	COG1280	lysine exporter protein (LysE YggA)
TH3_12005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TH3_12015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TH3_12045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TH3_12060	COG1686	Belongs to the peptidase S11 family
TH3_12070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TH3_12080	COG0484	heat shock protein binding
TH3_12090	COG1192	Involved in chromosome partitioning
TH3_12100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_12105	COG2342	PFAM TM1410 hypothetical-related protein
TH3_12135	COG1522	sequence-specific DNA binding
TH3_12145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TH3_12150	COG1024	Enoyl-CoA hydratase
TH3_12170	COG0840	transmembrane signaling receptor activity
TH3_12195	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TH3_12210	COG0583	DNA-binding transcription factor activity
TH3_12225	COG2084	Dehydrogenase
TH3_12230	COG0793	Belongs to the peptidase S41A family
TH3_12235	COG1960	acyl-CoA dehydrogenase activity
TH3_12240	COG0795	lipopolysaccharide-transporting ATPase activity
TH3_12250	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TH3_12255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TH3_12265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TH3_12270	COG0194	GDP metabolic process
TH3_12275	COG1561	YicC-like family, N-terminal region
TH3_12285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TH3_12290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TH3_12305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TH3_12315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TH3_12325	COG0359	binds to the 23S rRNA
TH3_12330	COG0305	Participates in initiation and elongation during chromosome replication
TH3_12335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TH3_12340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TH3_12345	COG1127	ABC transporter
TH3_12360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TH3_12365	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_12380	COG0667	Aldo Keto reductase
TH3_12385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TH3_12390	COG1160	GTP binding
TH3_12420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TH3_12425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TH3_12425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TH3_12435	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TH3_12440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TH3_12450	COG1902	pentaerythritol trinitrate reductase activity
TH3_12460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TH3_12465	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TH3_12475	COG1091	dTDP-4-dehydrorhamnose reductase activity
TH3_12485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TH3_12490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TH3_12495	COG0546	phosphoglycolate phosphatase activity
TH3_12505	COG4214	carbohydrate transport
TH3_12515	COG4213	ABC transporter substrate-binding protein
TH3_12540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TH3_12555	COG1234	tRNA 3'-trailer cleavage
TH3_12565	COG4149	molybdate abc transporter
TH3_12570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TH3_12640	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TH3_12650	COG0745	RESPONSE REGULATOR receiver
TH3_12665	COG1283	sodium-dependent phosphate transmembrane transporter activity
TH3_12685	COG0367	asparagine synthase
TH3_12690	COG1522	sequence-specific DNA binding
TH3_12695	COG3284	Transcriptional regulator
TH3_12700	COG1012	belongs to the aldehyde dehydrogenase family
TH3_12710	COG2855	membrane
TH3_12715	COG0583	DNA-binding transcription factor activity
TH3_12725	COG1271	oxidase subunit
TH3_12730	COG1294	oxidase, subunit
TH3_12745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TH3_12760	COG1012	belongs to the aldehyde dehydrogenase family
TH3_12765	COG3724	N-succinylarginine dihydrolase activity
TH3_12770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_12775	COG1522	sequence-specific DNA binding
TH3_12780	COG0175	sulfate reduction
TH3_12795	COG4544	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
TH3_12800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TH3_12805	COG0587	DNA-directed DNA polymerase activity
TH3_12815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_12825	COG0747	negative chemotaxis
TH3_12840	COG1116	anion transmembrane transporter activity
TH3_12840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TH3_12850	COG2223	nitrite transmembrane transporter activity
TH3_12860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TH3_12865	COG2146	nitrite reductase [NAD(P)H] activity
TH3_12870	COG0243	molybdopterin cofactor binding
TH3_12875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TH3_12875	COG1648	precorrin-2 dehydrogenase activity
TH3_12880	COG0583	DNA-binding transcription factor activity
TH3_12905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TH3_12920	COG2827	Endonuclease containing a URI domain
TH3_12925	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_12930	COG2207	Transcriptional regulator
TH3_12940	COG0800	Aldolase
TH3_12945	COG3734	2-keto-3-deoxy-galactonokinase
TH3_12955	COG4638	Rieske (2fe-2S)
TH3_12960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TH3_12965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TH3_12975	COG2086	electron transfer activity
TH3_12985	COG0788	formyltetrahydrofolate deformylase activity
TH3_13000	COG1309	transcriptional regulator
TH3_13005	COG4774	siderophore transport
TH3_13035	COG4774	siderophore transport
TH3_13040	COG1120	ATPase activity
TH3_13045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TH3_13055	COG4114	ferric iron reductase
TH3_13070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TH3_13175	COG2948	multi-organism process
TH3_13185	COG4962	Type ii secretion system protein e
TH3_13225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TH3_13255	COG1204	response to ionizing radiation
TH3_13280	COG2186	Transcriptional regulator
TH3_13290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_13295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TH3_13300	COG0438	transferase activity, transferring glycosyl groups
TH3_13305	COG1063	alcohol dehydrogenase
TH3_13315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TH3_13345	COG3842	ATPase activity
TH3_13350	COG3842	ATPase activity
TH3_13360	COG0395	ABC-type sugar transport system, permease component
TH3_13375	COG0840	transmembrane signaling receptor activity
TH3_13390	COG0330	HflC and HflK could
TH3_13400	COG2076	Multidrug Resistance protein
TH3_13415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_13420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_13440	COG1309	transcriptional regulator
TH3_13460	COG0493	'glutamate synthase
TH3_13480	COG4208	sulfate ABC transporter
TH3_13515	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TH3_13535	COG3386	PFAM SMP-30 Gluconolaconase
TH3_13540	COG1120	ATPase activity
TH3_13555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TH3_13580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TH3_13600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_13605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TH3_13625	COG2017	converts alpha-aldose to the beta-anomer
TH3_13630	COG2186	Transcriptional regulator
TH3_13635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TH3_13655	COG0412	Dienelactone hydrolase
TH3_13660	COG0129	dihydroxy-acid dehydratase activity
TH3_13665	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_13670	COG4213	ABC transporter substrate-binding protein
TH3_13675	COG4214	carbohydrate transport
TH3_13690	COG1940	carbohydrate kinase activity
TH3_13695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TH3_13705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TH3_13735	COG1609	Transcriptional regulator
TH3_13740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TH3_13750	COG3383	formate dehydrogenase (NAD+) activity
TH3_13765	COG0583	DNA-binding transcription factor activity
TH3_13775	COG4191	Histidine kinase
TH3_13780	COG2204	response regulator
TH3_13785	COG1629	transport
TH3_13785	COG4774	siderophore transport
TH3_13795	COG4178	(ABC) transporter
TH3_13820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TH3_13875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TH3_13915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TH3_13920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TH3_13930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TH3_13940	COG2986	histidine ammonia-lyase
TH3_13980	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_13985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TH3_14005	COG0411	ABC transporter
TH3_14025	COG3483	tryptophan 2,3-dioxygenase activity
TH3_14040	COG1960	acyl-CoA dehydrogenase activity
TH3_14075	COG0673	inositol 2-dehydrogenase activity
TH3_14080	COG3718	enzyme involved in inositol metabolism
TH3_14090	COG3962	Belongs to the TPP enzyme family
TH3_14095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TH3_14100	COG1129	ABC transporter
TH3_14130	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TH3_14135	COG1609	Transcriptional regulator
TH3_14140	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_14200	COG2948	multi-organism process
TH3_14225	COG3451	type IV secretory pathway VirB4
TH3_14240	COG4962	Type ii secretion system protein e
TH3_14295	COG0601	transmembrane transport
TH3_14310	COG4172	Belongs to the ABC transporter superfamily
TH3_14320	COG0741	lytic transglycosylase activity
TH3_14325	COG0681	Belongs to the peptidase S26 family
TH3_14375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TH3_14395	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_14405	COG0842	Transport permease protein
TH3_14410	COG0842	Transport permease protein
TH3_14410	COG1129	ABC transporter
TH3_14415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_14480	COG2963	transposase activity
TH3_14485	COG1196	nuclear chromosome segregation
TH3_14485	COG0741	lytic transglycosylase activity
TH3_14485	COG0739	heme binding
TH3_14490	COG0583	DNA-binding transcription factor activity
TH3_14495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TH3_14500	COG4597	amino acid ABC transporter
TH3_14505	COG0765	amino acid transport
TH3_14510	COG1126	abc transporter atp-binding protein
TH3_14525	COG1965	Belongs to the frataxin family
TH3_14530	COG0254	rRNA binding
TH3_14550	COG0604	alcohol dehydrogenase
TH3_14550	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_14550	COG3321	synthase
TH3_14565	COG1349	DNA-binding transcription factor activity
TH3_14570	COG0583	DNA-binding transcription factor activity
TH3_14635	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TH3_14640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TH3_14655	COG0242	peptide deformylase activity
TH3_14660	COG1566	PFAM secretion protein HlyD family protein
TH3_14670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TH3_14675	COG2056	Na+-H+ antiporter family
TH3_14690	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TH3_14695	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TH3_14700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TH3_14705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TH3_14735	COG0542	response to heat
TH3_14755	COG2890	protein-(glutamine-N5) methyltransferase activity
TH3_14760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TH3_14765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TH3_14770	COG0124	histidyl-tRNA synthetase
TH3_14775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TH3_14785	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
TH3_14790	COG2070	2-Nitropropane dioxygenase
TH3_14800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TH3_14810	COG0500	methyltransferase
TH3_14830	COG0577	efflux transmembrane transporter activity
TH3_14830	COG1136	(ABC) transporter
TH3_14850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TH3_14855	COG2186	Transcriptional regulator
TH3_14870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TH3_14875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TH3_14880	COG0583	DNA-binding transcription factor activity
TH3_14885	COG0625	glutathione transferase activity
TH3_14890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TH3_14890	COG1017	nitric oxide dioxygenase activity
TH3_14900	COG1489	DNA binding
TH3_14905	COG0024	Methionine aminopeptidase
TH3_14910	COG2003	Belongs to the UPF0758 family
TH3_14925	COG0583	DNA-binding transcription factor activity
TH3_14950	COG4166	transmembrane transport
TH3_14955	COG0601	transmembrane transport
TH3_14960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_14975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TH3_15000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TH3_15000	COG2169	Transcriptional regulator
TH3_15005	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_15010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TH3_15015	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TH3_15020	COG0583	DNA-binding transcription factor activity
TH3_15025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TH3_15035	COG0583	DNA-binding transcription factor activity
TH3_15045	COG0504	CTP synthase activity
TH3_15050	COG2197	response regulator
TH3_15065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TH3_15070	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TH3_15075	COG0047	phosphoribosylformylglycinamidine synthase activity
TH3_15080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TH3_15100	COG0489	protein tyrosine kinase activity
TH3_15105	COG0330	HflC and HflK could
TH3_15125	COG0560	Phosphoserine phosphatase
TH3_15125	COG3830	Belongs to the UPF0237 family
TH3_15145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TH3_15150	COG0028	Belongs to the TPP enzyme family
TH3_15155	COG0440	acetolactate synthase activity
TH3_15160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TH3_15165	COG2313	pseudouridylate synthase activity
TH3_15180	COG0415	Belongs to the DNA photolyase family
TH3_15195	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TH3_15200	COG1530	ribonuclease E activity
TH3_15220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TH3_15230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TH3_15265	COG2197	response regulator
TH3_15285	COG0604	alcohol dehydrogenase
TH3_15290	COG3339	Conserved Protein
TH3_15315	COG0354	folic acid binding
TH3_15320	COG0574	Belongs to the PEP-utilizing enzyme family
TH3_15320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TH3_15330	COG0752	glycyl-tRNA synthetase alpha subunit
TH3_15340	COG2890	protein-(glutamine-N5) methyltransferase activity
TH3_15350	COG0142	geranyltranstransferase activity
TH3_15355	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_15375	COG3474	cytochrome
TH3_15385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TH3_15395	COG0589	response to stress
TH3_15410	COG3246	L-lysine catabolic process to acetate
TH3_15415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_15430	COG0784	Response regulator, receiver
TH3_15430	COG2205	protein histidine kinase activity
TH3_15430	COG5002	protein histidine kinase activity
TH3_15435	COG0367	asparagine synthase
TH3_15445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TH3_15450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TH3_15455	COG4774	siderophore transport
TH3_15480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TH3_15485	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TH3_15490	COG0306	phosphate transporter
TH3_15565	COG0277	FAD linked oxidase domain protein
TH3_15590	COG0559	Belongs to the binding-protein-dependent transport system permease family
TH3_15605	COG3811	Belongs to the UPF0386 family
TH3_15630	COG0069	glutamate synthase activity
TH3_15660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_15665	COG4221	oxidoreductase activity
TH3_15680	COG0840	transmembrane signaling receptor activity
TH3_15685	COG0840	transmembrane signaling receptor activity
TH3_15690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TH3_15705	COG3023	N-Acetylmuramoyl-L-alanine amidase
TH3_15720	COG1335	isochorismatase
TH3_15725	COG4977	sequence-specific DNA binding
TH3_15750	COG2001	Belongs to the MraZ family
TH3_15755	COG0275	rRNA processing
TH3_15770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TH3_15785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TH3_15800	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
TH3_15825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TH3_15835	COG1181	Belongs to the D-alanine--D-alanine ligase family
TH3_15840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TH3_15850	COG3842	ATPase activity
TH3_15865	COG1653	transport
TH3_15880	COG4608	Belongs to the ABC transporter superfamily
TH3_15885	COG0444	Belongs to the ABC transporter superfamily
TH3_15890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_15895	COG0601	transmembrane transport
TH3_15900	COG0747	negative chemotaxis
TH3_15905	COG1414	Transcriptional regulator
TH3_15910	COG0849	cell division
TH3_15915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TH3_15925	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TH3_15935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TH3_15955	COG0697	spore germination
TH3_15965	COG0667	Aldo Keto reductase
TH3_15970	COG0006	proline dipeptidase activity
TH3_15980	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_15985	COG0730	response to heat
TH3_15995	COG2264	protein methyltransferase activity
TH3_16000	COG0210	DNA helicase
TH3_16030	COG2814	Major facilitator Superfamily
TH3_16035	COG1410	methionine synthase
TH3_16035	COG0646	methionine synthase
TH3_16050	COG2226	methyltransferase
TH3_16055	COG2853	Lipoprotein
TH3_16065	COG0488	(ABC) transporter
TH3_16075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TH3_16095	COG0725	ABC transporter, periplasmic molybdate-binding protein
TH3_16100	COG4149	molybdate abc transporter
TH3_16105	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TH3_16115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TH3_16130	COG0446	pyridine nucleotide-disulphide oxidoreductase
TH3_16130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TH3_16140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_16145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_16160	COG2010	Cytochrome c
TH3_16165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TH3_16165	COG1648	precorrin-2 dehydrogenase activity
TH3_16170	COG2010	Cytochrome c
TH3_16215	COG1845	cytochrome c oxidase, subunit III
TH3_16225	COG0714	Associated with various cellular activities
TH3_16285	COG4263	nitrous-oxide reductase activity
TH3_16295	COG0745	RESPONSE REGULATOR receiver
TH3_16300	COG2205	protein histidine kinase activity
TH3_16305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TH3_16310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TH3_16315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TH3_16320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TH3_16335	COG0505	Belongs to the CarA family
TH3_16340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TH3_16345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TH3_16355	COG1522	sequence-specific DNA binding
TH3_16360	COG0492	ferredoxin-NADP+ reductase activity
TH3_16365	COG0583	DNA-binding transcription factor activity
TH3_16375	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TH3_16380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TH3_16385	COG0783	Belongs to the Dps family
TH3_16395	COG0154	amidase activity
TH3_16420	COG4336	lyase activity
TH3_16425	COG0583	DNA-binding transcription factor activity
TH3_16430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TH3_16440	COG0556	nucleotide-excision repair
TH3_16455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TH3_16460	COG0450	alkyl hydroperoxide reductase
TH3_16465	COG0583	DNA-binding transcription factor activity
TH3_16480	COG4459	periplasmic nitrate reductase
TH3_16500	COG3043	anaerobic respiration
TH3_16505	COG3005	denitrification pathway
TH3_16510	COG1618	nucleotide phosphatase activity, acting on free nucleotides
TH3_16510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TH3_16515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TH3_16515	COG0519	Catalyzes the synthesis of GMP from XMP
TH3_16530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TH3_16535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TH3_16590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TH3_16620	COG0745	RESPONSE REGULATOR receiver
TH3_16625	COG1846	Transcriptional regulator
TH3_16630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TH3_16635	COG0625	glutathione transferase activity
TH3_16640	COG3119	arylsulfatase activity
TH3_16645	COG0583	DNA-binding transcription factor activity
TH3_16655	COG0408	coproporphyrinogen oxidase activity
TH3_16660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TH3_16685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TH3_16715	COG1072	(Pantothenic acid kinase))
TH3_16750	COG2132	Multicopper oxidase
TH3_16760	COG1522	sequence-specific DNA binding
TH3_16790	COG1396	sequence-specific DNA binding
TH3_16805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TH3_16810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TH3_16815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TH3_16820	COG1321	iron dependent repressor
TH3_16825	COG0803	Belongs to the bacterial solute-binding protein 9 family
TH3_16830	COG1121	(ABC) transporter
TH3_16835	COG1321	iron dependent repressor
TH3_16835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TH3_16840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TH3_16860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TH3_16865	COG1360	Flagellar Motor Protein
TH3_16875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TH3_16880	COG0612	Peptidase, M16
TH3_16885	COG0612	Peptidase, M16
TH3_16895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TH3_16905	COG0196	riboflavin kinase activity
TH3_16910	COG2030	dehydratase
TH3_16915	COG2226	methyltransferase
TH3_16965	COG0737	Belongs to the 5'-nucleotidase family
TH3_16975	COG2207	Transcriptional regulator
TH3_16990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TH3_16995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TH3_17000	COG1960	acyl-CoA dehydrogenase activity
TH3_17005	COG0583	DNA-binding transcription factor activity
TH3_17020	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TH3_17070	COG2205	protein histidine kinase activity
TH3_17070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TH3_17080	COG4251	negative regulation of phosphorylation
TH3_17090	COG2832	Protein of unknown function (DUF454)
TH3_17120	COG1320	monovalent cation:proton antiporter activity
TH3_17125	COG2212	antiporter activity
TH3_17130	COG1863	multisubunit Na H antiporter MnhE subunit
TH3_17135	COG0651	ATP synthesis coupled electron transport
TH3_17140	COG1006	Multisubunit Na H antiporter MnhC subunit
TH3_17145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TH3_17145	COG2111	Na H antiporter
TH3_17160	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TH3_17165	COG0410	ABC transporter
TH3_17180	COG0559	Belongs to the binding-protein-dependent transport system permease family
TH3_17205	COG0733	neurotransmitter:sodium symporter activity
TH3_17220	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TH3_17225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TH3_17235	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TH3_17240	COG1138	Cytochrome C-type biogenesis protein
TH3_17245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TH3_17250	COG3088	subunit of a heme lyase
TH3_17255	COG3088	subunit of a heme lyase
TH3_17255	COG4235	cytochrome complex assembly
TH3_17260	COG1349	DNA-binding transcription factor activity
TH3_17265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TH3_17275	COG1129	ABC transporter
TH3_17280	COG1172	Belongs to the binding-protein-dependent transport system permease family
TH3_17285	COG1172	Belongs to the binding-protein-dependent transport system permease family
TH3_17305	COG0739	heme binding
TH3_17305	COG0741	lytic transglycosylase activity
TH3_17305	COG1196	nuclear chromosome segregation
TH3_17310	COG1573	uracil-dna glycosylase
TH3_17320	COG1012	belongs to the aldehyde dehydrogenase family
TH3_17330	COG0583	DNA-binding transcription factor activity
TH3_17345	COG1473	amidohydrolase
TH3_17370	COG3646	Phage regulatory protein
TH3_17385	COG0328	RNA-DNA hybrid ribonuclease activity
TH3_17440	COG3142	Participates in the control of copper homeostasis
TH3_17445	COG1940	carbohydrate kinase activity
TH3_17450	COG0612	Peptidase, M16
TH3_17460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_17485	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TH3_17490	COG0109	protoheme IX farnesyltransferase activity
TH3_17495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TH3_17500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TH3_17510	COG1678	Uncharacterized ACR, COG1678
TH3_17515	COG4232	protein-disulfide reductase activity
TH3_17525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TH3_17525	COG0678	peroxiredoxin activity
TH3_17540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TH3_17545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TH3_17550	COG0509	glycine decarboxylation via glycine cleavage system
TH3_17555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TH3_17570	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TH3_17615	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TH3_17620	COG0625	glutathione transferase activity
TH3_17625	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TH3_17630	COG1116	anion transmembrane transporter activity
TH3_17635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_17640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TH3_17645	COG3604	Transcriptional regulator
TH3_17655	COG2096	Adenosyltransferase
TH3_17670	COG1250	3-hydroxyacyl-CoA dehydrogenase
TH3_17675	COG1070	Carbohydrate kinase
TH3_17680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TH3_17685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TH3_17700	COG0019	diaminopimelate decarboxylase activity
TH3_17710	COG2207	Transcriptional regulator
TH3_17730	COG2884	Cell division ATP-binding protein ftsE
TH3_17760	COG0697	spore germination
TH3_17765	COG0287	Prephenate dehydrogenase
TH3_17780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TH3_17785	COG2813	Specifically methylates the guanine in position
TH3_17785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TH3_17800	COG0314	molybdopterin synthase activity
TH3_17805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TH3_17810	COG2233	PERMEase
TH3_17820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TH3_17825	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_17840	COG0745	RESPONSE REGULATOR receiver
TH3_17845	COG0704	Plays a role in the regulation of phosphate uptake
TH3_17855	COG0581	inorganic phosphate transmembrane transporter activity
TH3_17860	COG0573	inorganic phosphate transmembrane transporter activity
TH3_17865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TH3_17880	COG0247	lactate metabolic process
TH3_17885	COG0277	FAD linked oxidase domain protein
TH3_17890	COG0277	FAD linked oxidase domain protein
TH3_17895	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TH3_17910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_17920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TH3_17935	COG0747	negative chemotaxis
TH3_17965	COG1968	undecaprenyl-diphosphatase activity
TH3_17990	COG0778	Nitroreductase
TH3_18005	COG1058	Belongs to the CinA family
TH3_18005	COG1546	Belongs to the CinA family
TH3_18035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TH3_18040	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TH3_18050	COG1639	'signal transduction protein
TH3_18065	COG1742	UPF0060 membrane protein
TH3_18075	COG1522	sequence-specific DNA binding
TH3_18080	COG3186	Phenylalanine-4-hydroxylase
TH3_18105	COG1703	isobutyryl-CoA mutase activity
TH3_18120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TH3_18150	COG2095	MarC family integral membrane protein
TH3_18185	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_18195	COG3550	peptidyl-serine autophosphorylation
TH3_18200	COG0583	DNA-binding transcription factor activity
TH3_18205	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TH3_18215	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TH3_18220	COG1122	ATPase activity
TH3_18225	COG1268	BioY protein
TH3_18230	COG0640	Transcriptional regulator
TH3_18240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TH3_18245	COG0830	nickel cation binding
TH3_18250	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TH3_18255	COG0804	urea catabolic process
TH3_18260	COG0832	Belongs to the urease beta subunit family
TH3_18265	COG0831	urea catabolic process
TH3_18270	COG0829	nickel cation binding
TH3_18275	COG0410	ABC transporter
TH3_18280	COG0411	ABC transporter
TH3_18315	COG0583	DNA-binding transcription factor activity
TH3_18330	COG0840	transmembrane signaling receptor activity
TH3_18335	COG0840	transmembrane signaling receptor activity
TH3_18360	COG1129	ABC transporter
TH3_18365	COG0590	tRNA wobble adenosine to inosine editing
TH3_18375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TH3_18395	COG3195	allantoin biosynthetic process
TH3_18395	COG3648	Uricase
TH3_18400	COG4266	Belongs to the allantoicase family
TH3_18410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TH3_18425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TH3_18445	COG2030	dehydratase
TH3_18450	COG2301	Belongs to the HpcH HpaI aldolase family
TH3_18505	COG1842	Phage shock protein A
TH3_18510	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TH3_18520	COG1960	acyl-CoA dehydrogenase activity
TH3_18525	COG0288	reversible hydration of carbon dioxide
TH3_18540	COG0183	Belongs to the thiolase family
TH3_18545	COG1960	acyl-CoA dehydrogenase activity
TH3_18560	COG0513	Belongs to the DEAD box helicase family
TH3_18575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TH3_18580	COG3474	cytochrome
TH3_18595	COG1280	lysine exporter protein (LysE YggA)
TH3_18610	COG3263	regulation of cellular component size
TH3_18615	COG1522	sequence-specific DNA binding
TH3_18640	COG2154	pterin-4-alpha-carbinolamine dehydratase
TH3_18645	COG1573	uracil-dna glycosylase
TH3_18655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TH3_18665	COG1280	lysine exporter protein (LysE YggA)
TH3_18675	COG4172	Belongs to the ABC transporter superfamily
TH3_18680	COG4239	(ABC) transporter, permease
TH3_18685	COG4174	ABC transporter (Permease)
TH3_18690	COG4166	transmembrane transport
TH3_18695	COG0583	DNA-binding transcription factor activity
TH3_18735	COG0693	protein deglycase activity
TH3_18760	COG1522	sequence-specific DNA binding
TH3_18765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_18775	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_18790	COG2986	histidine ammonia-lyase
TH3_18795	COG1228	amidohydrolase
TH3_18820	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TH3_18825	COG1741	Belongs to the pirin family
TH3_18830	COG0667	Aldo Keto reductase
TH3_18855	COG4181	ATPase activity
TH3_18860	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TH3_18865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TH3_18875	COG0670	Belongs to the BI1 family
TH3_18885	COG0501	Belongs to the peptidase M48B family
TH3_18895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_18905	COG2902	Dehydrogenase
TH3_18910	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TH3_18930	COG3118	belongs to the thioredoxin family
TH3_18940	COG2835	tetraacyldisaccharide 4'-kinase activity
TH3_18950	COG3047	cAMP biosynthetic process
TH3_18955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TH3_18965	COG0004	ammonium transporteR
TH3_18985	COG0840	transmembrane signaling receptor activity
TH3_18990	COG0840	transmembrane signaling receptor activity
TH3_19000	COG1074	ATP-dependent DNA helicase activity
TH3_19010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TH3_19020	COG0802	atpase or kinase
TH3_19035	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_19045	COG1733	regulation of RNA biosynthetic process
TH3_19050	COG4702	Belongs to the UPF0303 family
TH3_19055	COG0481	GTPase activity
TH3_19060	COG4251	negative regulation of phosphorylation
TH3_19070	COG0072	phenylalanine-tRNA ligase activity
TH3_19075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TH3_19080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TH3_19085	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TH3_19095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TH3_19130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TH3_19140	COG0181	hydroxymethylbilane synthase activity
TH3_19160	COG0138	bifunctional purine biosynthesis protein purh
TH3_19170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TH3_19175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TH3_19180	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TH3_19190	COG2183	response to ionizing radiation
TH3_19200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TH3_19220	COG1012	belongs to the aldehyde dehydrogenase family
TH3_19240	COG0583	DNA-binding transcription factor activity
TH3_19245	COG0840	transmembrane signaling receptor activity
TH3_19250	COG2807	transmembrane transport
TH3_19280	COG2067	long-chain fatty acid transport protein
TH3_19285	COG0318	PFAM AMP-dependent synthetase and ligase
TH3_19290	COG0789	Transcriptional regulator
TH3_19295	COG0183	Belongs to the thiolase family
TH3_19300	COG1024	Enoyl-CoA hydratase
TH3_19300	COG1250	3-hydroxyacyl-CoA dehydrogenase
TH3_19305	COG1960	acyl-CoA dehydrogenase activity
TH3_19315	COG1024	Enoyl-CoA hydratase
TH3_19320	COG0300	oxidoreductase activity
TH3_19330	COG2943	transferase activity, transferring hexosyl groups
TH3_19340	COG2207	Transcriptional regulator
TH3_19370	COG0730	response to heat
TH3_19375	COG2186	Transcriptional regulator
TH3_19390	COG1176	ABC-type spermidine putrescine transport system, permease component I
TH3_19400	COG3842	ATPase activity
TH3_19430	COG0583	DNA-binding transcription factor activity
TH3_19435	COG1741	Belongs to the pirin family
TH3_19465	COG2200	EAL domain
TH3_19475	COG0642	Histidine kinase
TH3_19520	COG3181	Tripartite tricarboxylate transporter family receptor
TH3_19540	COG3180	Ammonia monooxygenase
TH3_19555	COG1596	polysaccharide export
TH3_19560	COG0028	Belongs to the TPP enzyme family
TH3_19580	COG1131	(ABC) transporter
TH3_19590	COG0133	tryptophan synthase activity
TH3_19600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TH3_19605	COG0285	dihydrofolate synthase activity
TH3_19615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TH3_19615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TH3_19620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TH3_19640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TH3_19650	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TH3_19655	COG0792	nuclease activity
TH3_19680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TH3_19690	COG2211	Major facilitator Superfamily
TH3_19695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TH3_19700	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TH3_19705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TH3_19710	COG1137	ATPase activity
TH3_19725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TH3_19725	COG0517	IMP dehydrogenase activity
TH3_19745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TH3_19750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TH3_19755	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TH3_19760	COG1420	regulation of RNA biosynthetic process
TH3_19780	COG0697	spore germination
TH3_19800	COG0583	DNA-binding transcription factor activity
TH3_19815	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TH3_19830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TH3_19835	COG2992	FlgJ-related protein
TH3_19850	COG0281	malic enzyme
TH3_19850	COG0280	phosphate acetyltransferase
TH3_19860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TH3_19870	COG0728	peptidoglycan biosynthetic process
TH3_19875	COG0180	Tryptophanyl-tRNA synthetase
TH3_19890	COG0745	RESPONSE REGULATOR receiver
TH3_19900	COG0352	thiamine-phosphate diphosphorylase activity
TH3_19945	COG1475	DNA binding
TH3_19950	COG1192	Involved in chromosome partitioning
TH3_19960	COG0445	tRNA wobble uridine modification
TH3_19965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TH3_19980	COG1331	Highly conserved protein containing a thioredoxin domain
TH3_19995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TH3_20000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TH3_20030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TH3_20035	COG0237	dephospho-CoA kinase activity
TH3_20045	COG0424	maF-like protein
TH3_20050	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TH3_20070	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TH3_20075	COG3030	protein affecting phage T7 exclusion by the F plasmid
TH3_20080	COG4395	Tim44
TH3_20190	COG0583	DNA-binding transcription factor activity
TH3_20195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TH3_20225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TH3_20235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TH3_20245	COG0131	Imidazoleglycerol-phosphate dehydratase
TH3_20250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TH3_20260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TH3_20265	COG5002	protein histidine kinase activity
TH3_20285	COG0756	dUTP diphosphatase activity
TH3_20290	COG1959	2 iron, 2 sulfur cluster binding
TH3_20300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TH3_20310	COG1280	lysine exporter protein (LysE YggA)
TH3_20320	COG1285	pathogenesis
TH3_20325	COG1609	Transcriptional regulator
TH3_20330	COG2723	6-phospho-beta-galactosidase activity
TH3_20335	COG1653	transport
TH3_20395	COG1702	phosphate starvation-inducible protein PhoH
TH3_20405	COG1253	flavin adenine dinucleotide binding
TH3_20410	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TH3_20415	COG1396	sequence-specific DNA binding
TH3_20420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TH3_20425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TH3_20430	COG1595	DNA-templated transcription, initiation
TH3_20440	COG1629	transport
TH3_20440	COG4206	TonB-dependent receptor
TH3_20450	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
TH3_20455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_20475	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TH3_20490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TH3_20495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TH3_20500	COG1185	polyribonucleotide nucleotidyltransferase activity
TH3_20515	COG1592	Rubrerythrin
TH3_20525	COG1120	ATPase activity
TH3_20530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TH3_20540	COG2226	methyltransferase
TH3_20550	COG2186	Transcriptional regulator
TH3_20570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TH3_20575	COG1268	BioY protein
TH3_20590	COG1305	Transglutaminase-like
TH3_20600	COG2308	Evidence 4 Homologs of previously reported genes of
TH3_20605	COG2875	Belongs to the precorrin methyltransferase family
TH3_20630	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
TH3_20635	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TH3_20660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TH3_20665	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TH3_20670	COG0588	phosphoglycerate mutase activity
TH3_20710	COG1492	cobalamin metabolic process
TH3_20745	COG0840	transmembrane signaling receptor activity
TH3_20755	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TH3_20770	COG1999	signal sequence binding
TH3_20775	COG1797	cobyrinic acid a,c-diamide synthase activity
TH3_20780	COG2983	Belongs to the UPF0260 family
TH3_20790	COG1234	tRNA 3'-trailer cleavage
TH3_20800	COG0071	Belongs to the small heat shock protein (HSP20) family
TH3_20810	COG0519	Catalyzes the synthesis of GMP from XMP
TH3_20825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TH3_20845	COG0539	negative regulation of cytoplasmic translation
TH3_20850	COG0616	signal peptide processing
TH3_20855	COG0776	regulation of translation
TH3_20865	COG0284	orotidine-5'-phosphate decarboxylase activity
TH3_20870	COG2814	Major facilitator Superfamily
TH3_20875	COG0730	response to heat
TH3_20880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TH3_20885	COG1024	Enoyl-CoA hydratase
TH3_20890	COG0268	Binds directly to 16S ribosomal RNA
TH3_21043	COG2801	Transposase and inactivated derivatives
TH3_21048	COG2963	transposase activity
TH3_21093	COG1487	ribonuclease activity
TH3_21098	COG4691	Plasmid stability protein
TH3_21233	COG3550	peptidyl-serine autophosphorylation
TH3_21263	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TH3_21348	COG5642	Protein of unknown function (DUF2384)
TH3_21388	COG1414	Transcriptional regulator
TH3_21393	COG0277	FAD linked oxidase domain protein
TH3_21398	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_21403	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TH3_21433	COG5642	Protein of unknown function (DUF2384)
TH3_21438	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TH3_21558	COG0358	DNA primase activity
TH3_21788	COG2356	endonuclease I
TH3_21818	COG1396	sequence-specific DNA binding