locus-tag	class	description
L6172_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L6172_00025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_00035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_00040	COG1917	Cupin 2, conserved barrel domain protein
L6172_00050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6172_00055	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
L6172_00070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6172_00075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L6172_00105	COG1280	lysine exporter protein (LysE YggA)
L6172_00115	COG0137	argininosuccinate synthase activity
L6172_00125	COG0840	transmembrane signaling receptor activity
L6172_00125	COG3290	protein histidine kinase activity
L6172_00130	COG1346	cytolysis
L6172_00140	COG1393	Belongs to the ArsC family
L6172_00150	COG2137	regulation of response to DNA damage stimulus
L6172_00155	COG0842	Transport permease protein
L6172_00160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6172_00165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L6172_00170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L6172_00180	COG0589	response to stress
L6172_00185	COG0659	secondary active sulfate transmembrane transporter activity
L6172_00190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6172_00195	COG1322	Protein conserved in bacteria
L6172_00200	COG0242	peptide deformylase activity
L6172_00205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L6172_00215	COG0583	DNA-binding transcription factor activity
L6172_00240	COG2358	TRAP transporter, solute receptor (TAXI family
L6172_00245	COG2204	response regulator
L6172_00250	COG4191	Histidine kinase
L6172_00255	COG0745	RESPONSE REGULATOR receiver
L6172_00260	COG0642	Histidine kinase
L6172_00270	COG1660	Displays ATPase and GTPase activities
L6172_00275	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6172_00275	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6172_00285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L6172_00290	COG3667	copper resistance
L6172_00295	COG2132	Multicopper oxidase
L6172_00310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L6172_00335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6172_00345	COG1078	dGTPase activity
L6172_00350	COG2205	protein histidine kinase activity
L6172_00375	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
L6172_00395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_00410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L6172_00415	COG1802	Transcriptional regulator
L6172_00425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L6172_00435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L6172_00440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L6172_00445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L6172_00455	COG2816	NAD+ diphosphatase activity
L6172_00475	COG0583	DNA-binding transcription factor activity
L6172_00485	COG0625	glutathione transferase activity
L6172_00495	COG3128	pkhd-type hydroxylase
L6172_00500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6172_00505	COG2171	N-acyltransferase activity
L6172_00515	COG2200	EAL domain
L6172_00515	COG2199	diguanylate cyclase activity
L6172_00520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
L6172_00535	COG3237	CsbD-like
L6172_00545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L6172_00545	COG0512	Glutamine amidotransferase of anthranilate synthase
L6172_00550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6172_00565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L6172_00585	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
L6172_00615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6172_00625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6172_00640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6172_00655	COG2818	Glycosylase
L6172_00660	COG3852	Histidine kinase
L6172_00670	COG0398	Pfam SNARE associated Golgi protein
L6172_00695	COG3001	Fructosamine kinase
L6172_00700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L6172_00715	COG0534	Mate efflux family protein
L6172_00720	COG0584	glycerophosphoryl diester phosphodiesterase
L6172_00775	COG1192	Involved in chromosome partitioning
L6172_00790	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L6172_00795	COG0657	acetylesterase activity
L6172_00805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6172_00815	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
L6172_00820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L6172_00825	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
L6172_00830	COG3639	organic phosphonate transmembrane transporter activity
L6172_00840	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
L6172_00845	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
L6172_00845	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L6172_00850	COG3454	Phosphonate metabolism
L6172_00855	COG4778	phosphonate C-P lyase system protein PhnL
L6172_00860	COG4107	phosphonate C-P lyase system protein PhnK
L6172_00865	COG3627	carbon phosphorus lyase activity
L6172_00870	COG3626	phosphonate metabolism
L6172_00880	COG3624	Phosphonate C-P lyase system protein PhnG
L6172_00885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6172_00895	COG5001	Diguanylate cyclase
L6172_00900	COG0024	Methionine aminopeptidase
L6172_00905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L6172_00920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_00930	COG2081	HI0933 family
L6172_00935	COG3706	GGDEF domain
L6172_00960	COG1187	pseudouridine synthase activity
L6172_00965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L6172_00970	COG3806	Anti-sigma factor
L6172_00975	COG1595	DNA-templated transcription, initiation
L6172_00990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L6172_00995	COG2211	Major facilitator Superfamily
L6172_00995	COG2190	(PTS) system
L6172_01010	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_01020	COG0564	pseudouridine synthase activity
L6172_01030	COG1803	Methylglyoxal synthase
L6172_01050	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6172_01055	COG0567	Dehydrogenase, E1 component
L6172_01060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L6172_01065	COG0045	succinate-CoA ligase (ADP-forming) activity
L6172_01070	COG0039	L-malate dehydrogenase activity
L6172_01075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L6172_01085	COG1196	nuclear chromosome segregation
L6172_01085	COG3264	Mechanosensitive ion channel
L6172_01090	COG0494	nUDIX hydrolase
L6172_01100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L6172_01135	COG0174	glutamine synthetase
L6172_01160	COG4974	Belongs to the 'phage' integrase family
L6172_01170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L6172_01190	COG0625	glutathione transferase activity
L6172_01200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L6172_01225	COG0784	Response regulator, receiver
L6172_01230	COG4235	cytochrome complex assembly
L6172_01235	COG1138	Cytochrome C-type biogenesis protein
L6172_01240	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6172_01245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L6172_01250	COG1702	phosphate starvation-inducible protein PhoH
L6172_01260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6172_01265	COG0798	PFAM Bile acid sodium symporter
L6172_01315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6172_01335	COG1609	Transcriptional regulator
L6172_01345	COG0519	Catalyzes the synthesis of GMP from XMP
L6172_01355	COG1872	DUF167
L6172_01360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L6172_01365	COG0471	metal ion transport
L6172_01365	COG3273	potassium ion transport
L6172_01370	COG3214	Protein conserved in bacteria
L6172_01375	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_01385	COG0395	ABC-type sugar transport system, permease component
L6172_01405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6172_01410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L6172_01425	COG1595	DNA-templated transcription, initiation
L6172_01435	COG0066	3-isopropylmalate dehydratase activity
L6172_01445	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L6172_01465	COG0228	four-way junction DNA binding
L6172_01470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L6172_01485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6172_01495	COG2217	Heavy metal translocating P-type atpase
L6172_01510	COG2010	Cytochrome c
L6172_01535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L6172_01540	COG0126	phosphoglycerate kinase activity
L6172_01560	COG4106	trans-aconitate 2-methyltransferase activity
L6172_01570	COG1051	belongs to the nudix hydrolase family
L6172_01580	COG0793	Belongs to the peptidase S41A family
L6172_01585	COG4942	peptidase
L6172_01590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L6172_01595	COG1760	l-serine dehydratase
L6172_01600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L6172_01615	COG0799	negative regulation of ribosome biogenesis
L6172_01620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L6172_01630	COG5265	(ABC) transporter
L6172_01655	COG3706	GGDEF domain
L6172_01680	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
L6172_01690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L6172_01695	COG0402	S-adenosylhomocysteine deaminase activity
L6172_01705	COG4603	Belongs to the binding-protein-dependent transport system permease family
L6172_01710	COG3845	ABC transporter
L6172_01715	COG1744	ABC transporter substrate-binding protein PnrA-like
L6172_01730	COG1194	a g-specific adenine glycosylase
L6172_01740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6172_01740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L6172_01745	COG1196	nuclear chromosome segregation
L6172_01770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L6172_01780	COG0435	Glutathione S-transferase
L6172_01785	COG0583	DNA-binding transcription factor activity
L6172_01805	COG0714	Associated with various cellular activities
L6172_01825	COG0617	tRNA 3'-terminal CCA addition
L6172_01840	COG2202	Pas domain
L6172_01840	COG2200	EAL domain
L6172_01840	COG2199	diguanylate cyclase activity
L6172_01845	COG4974	Belongs to the 'phage' integrase family
L6172_01865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L6172_01870	COG4536	flavin adenine dinucleotide binding
L6172_01920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L6172_01945	COG1595	DNA-templated transcription, initiation
L6172_01950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6172_01965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L6172_01975	COG4774	siderophore transport
L6172_01990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L6172_01995	COG1238	metal cluster binding
L6172_02015	COG0395	ABC-type sugar transport system, permease component
L6172_02020	COG1175	transmembrane transport
L6172_02035	COG0826	peptidase U32
L6172_02040	COG0826	peptidase U32
L6172_02065	COG0714	Associated with various cellular activities
L6172_02090	COG0535	radical SAM domain protein
L6172_02120	COG2010	Cytochrome c
L6172_02125	COG1648	precorrin-2 dehydrogenase activity
L6172_02125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6172_02130	COG2010	Cytochrome c
L6172_02145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6172_02150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6172_02155	COG1063	alcohol dehydrogenase
L6172_02170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_02175	COG1802	Transcriptional regulator
L6172_02180	COG1312	Catalyzes the dehydration of D-mannonate
L6172_02185	COG0246	Mannitol dehydrogenase
L6172_02205	COG2814	Major facilitator Superfamily
L6172_02215	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L6172_02225	COG3842	ATPase activity
L6172_02245	COG1609	Transcriptional regulator
L6172_02255	COG1802	Transcriptional regulator
L6172_02285	COG5002	protein histidine kinase activity
L6172_02290	COG0745	RESPONSE REGULATOR receiver
L6172_02295	COG0745	RESPONSE REGULATOR receiver
L6172_02300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L6172_02320	COG5002	protein histidine kinase activity
L6172_02335	COG3800	Transcriptional regulator
L6172_02335	COG1396	sequence-specific DNA binding
L6172_02360	COG0410	ABC transporter
L6172_02370	COG1522	sequence-specific DNA binding
L6172_02390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_02405	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L6172_02415	COG0625	glutathione transferase activity
L6172_02420	COG1454	alcohol dehydrogenase
L6172_02440	COG0019	diaminopimelate decarboxylase activity
L6172_02450	COG1309	transcriptional regulator
L6172_02460	COG1609	Transcriptional regulator
L6172_02465	COG1129	ABC transporter
L6172_02470	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6172_02475	COG1879	ABC-type sugar transport system periplasmic component
L6172_02485	COG0673	inositol 2-dehydrogenase activity
L6172_02495	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L6172_02510	COG0154	amidase activity
L6172_02555	COG1522	sequence-specific DNA binding
L6172_02560	COG3608	succinylglutamate desuccinylase aspartoacylase
L6172_02565	COG0006	proline dipeptidase activity
L6172_02570	COG2423	ornithine cyclodeaminase activity
L6172_02575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6172_02585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_02590	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L6172_02595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6172_02600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_02605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6172_02625	COG1234	tRNA 3'-trailer cleavage
L6172_02640	COG0456	acetyltransferase
L6172_02645	COG1733	regulation of RNA biosynthetic process
L6172_02685	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
L6172_02720	COG0321	lipoyl(octanoyl) transferase activity
L6172_02730	COG0280	phosphate acetyltransferase
L6172_02730	COG0281	malic enzyme
L6172_02735	COG2239	Acts as a magnesium transporter
L6172_02840	COG2274	protein secretion by the type I secretion system
L6172_02845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6172_02855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L6172_02865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L6172_02870	COG0706	membrane insertase activity
L6172_02875	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L6172_02880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L6172_02885	COG3706	GGDEF domain
L6172_02890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6172_02895	COG0552	protein localization to endoplasmic reticulum
L6172_02905	COG0783	Belongs to the Dps family
L6172_02935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6172_02965	COG0742	ribosomal rna small subunit methyltransferase
L6172_02970	COG1187	pseudouridine synthase activity
L6172_02975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L6172_02980	COG0590	tRNA wobble adenosine to inosine editing
L6172_02985	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
L6172_02990	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L6172_03000	COG4221	oxidoreductase activity
L6172_03005	COG2207	Transcriptional regulator
L6172_03015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6172_03020	COG1120	ATPase activity
L6172_03025	COG0151	Belongs to the GarS family
L6172_03030	COG1570	exodeoxyribonuclease VII activity
L6172_03040	COG0405	Gamma-glutamyltransferase
L6172_03060	COG1663	tetraacyldisaccharide 4'-kinase activity
L6172_03065	COG1519	Transferase
L6172_03075	COG1132	(ABC) transporter
L6172_03085	COG0438	transferase activity, transferring glycosyl groups
L6172_03095	COG1597	lipid kinase activity
L6172_03100	COG0312	modulator of DNA gyrase
L6172_03120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L6172_03145	COG2264	protein methyltransferase activity
L6172_03155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L6172_03185	COG3639	organic phosphonate transmembrane transporter activity
L6172_03200	COG1349	DNA-binding transcription factor activity
L6172_03235	COG1280	lysine exporter protein (LysE YggA)
L6172_03240	COG4608	Belongs to the ABC transporter superfamily
L6172_03245	COG0444	Belongs to the ABC transporter superfamily
L6172_03250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6172_03255	COG0601	transmembrane transport
L6172_03260	COG0747	negative chemotaxis
L6172_03280	COG0312	modulator of DNA gyrase
L6172_03290	COG0326	Molecular chaperone. Has ATPase activity
L6172_03295	COG1612	heme a metabolic process
L6172_03305	COG0175	sulfate reduction
L6172_03340	COG1522	sequence-specific DNA binding
L6172_03345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L6172_03360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_03365	COG3265	gluconokinase activity
L6172_03370	COG1609	Transcriptional regulator
L6172_03380	COG1739	Uncharacterized protein family UPF0029
L6172_03390	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L6172_03405	COG0393	Putative heavy-metal-binding
L6172_03410	COG0393	Putative heavy-metal-binding
L6172_03420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L6172_03435	COG0789	Transcriptional regulator
L6172_03465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6172_03475	COG0010	Belongs to the arginase family
L6172_03480	COG3842	ATPase activity
L6172_03485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6172_03500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L6172_03505	COG0668	transmembrane transport
L6172_03510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L6172_03515	COG2962	Rard protein
L6172_03540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6172_03560	COG2198	Histidine kinase
L6172_03560	COG0784	Response regulator, receiver
L6172_03560	COG0643	Histidine kinase
L6172_03585	COG0745	RESPONSE REGULATOR receiver
L6172_03600	COG0442	prolyl-tRNA aminoacylation
L6172_03605	COG0861	Integral membrane protein TerC family
L6172_03610	COG4134	Bacterial extracellular solute-binding protein
L6172_03615	COG4135	transport system, permease component
L6172_03620	COG4136	ATPase activity
L6172_03625	COG3128	pkhd-type hydroxylase
L6172_03650	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6172_03655	COG2204	response regulator
L6172_03660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6172_03665	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6172_03675	COG1766	The M ring may be actively involved in energy transduction
L6172_03680	COG1749	Flagellar hook protein flgE
L6172_03695	COG1516	flagellar protein fliS
L6172_03700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
L6172_03730	COG4786	Flagellar basal body rod
L6172_03730	COG1256	bacterial-type flagellum assembly
L6172_03740	COG3951	Flagellar rod assembly protein muramidase FlgJ
L6172_03745	COG1706	bacterial-type flagellum-dependent cell motility
L6172_03760	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
L6172_03770	COG4786	Flagellar basal body rod
L6172_03775	COG4786	Flagellar basal body rod
L6172_03800	COG0745	RESPONSE REGULATOR receiver
L6172_03830	COG1338	Plays a role in the flagellum-specific transport system
L6172_03845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6172_03855	COG1815	bacterial-type flagellum-dependent cell motility
L6172_03860	COG1558	bacterial-type flagellum-dependent cell motility
L6172_03865	COG1677	Flagellar hook-basal body complex protein FliE
L6172_03870	COG1987	bacterial-type flagellum assembly
L6172_03875	COG1684	flagellar biosynthetic protein fliR
L6172_03880	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6172_03895	COG0583	DNA-binding transcription factor activity
L6172_03905	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L6172_03975	COG5487	UPF0391 membrane protein
L6172_03995	COG0697	spore germination
L6172_04000	COG1522	sequence-specific DNA binding
L6172_04055	COG0542	response to heat
L6172_04070	COG4187	Peptidase family M20/M25/M40
L6172_04075	COG0584	glycerophosphoryl diester phosphodiesterase
L6172_04080	COG0655	NAD(P)H dehydrogenase (quinone) activity
L6172_04105	COG1595	DNA-templated transcription, initiation
L6172_04115	COG0538	isocitrate dehydrogenase activity
L6172_04145	COG2015	COG2015, Alkyl sulfatase and related hydrolases
L6172_04160	COG0492	ferredoxin-NADP+ reductase activity
L6172_04180	COG1611	Belongs to the LOG family
L6172_04195	COG0688	phosphatidylethanolamine metabolic process
L6172_04255	COG0602	queuosine metabolic process
L6172_04260	COG0720	synthase
L6172_04265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L6172_04275	COG2226	methyltransferase
L6172_04290	COG2032	superoxide dismutase activity
L6172_04305	COG0495	leucyl-tRNA aminoacylation
L6172_04320	COG0438	transferase activity, transferring glycosyl groups
L6172_04350	COG0438	transferase activity, transferring glycosyl groups
L6172_04380	COG1643	Atp-dependent helicase
L6172_04405	COG0604	alcohol dehydrogenase
L6172_04405	COG3321	synthase
L6172_04405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6172_04405	COG4221	oxidoreductase activity
L6172_04415	COG0583	DNA-binding transcription factor activity
L6172_04435	COG2084	Dehydrogenase
L6172_04470	COG3247	response to pH
L6172_04485	COG3386	PFAM SMP-30 Gluconolaconase
L6172_04495	COG1199	ATP-dependent helicase activity
L6172_04515	COG1238	metal cluster binding
L6172_04520	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L6172_04525	COG1764	response to oxidative stress
L6172_04535	COG1846	Transcriptional regulator
L6172_04595	COG0506	proline dehydrogenase activity
L6172_04615	COG1609	Transcriptional regulator
L6172_04620	COG1840	ABC-type Fe3 transport system, periplasmic component
L6172_04630	COG3842	ATPase activity
L6172_04635	COG0483	inositol monophosphate 1-phosphatase activity
L6172_04655	COG1850	ribulose-bisphosphate carboxylase activity
L6172_04665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_04670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L6172_04675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_04935	COG0167	dihydroorotate dehydrogenase activity
L6172_04960	COG0697	spore germination
L6172_04970	COG2162	N-hydroxyarylamine O-acetyltransferase activity
L6172_04980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6172_04985	COG3842	ATPase activity
L6172_04990	COG0395	ABC-type sugar transport system, permease component
L6172_05005	COG0626	cystathionine gamma-synthase activity
L6172_05010	COG2186	Transcriptional regulator
L6172_05035	COG1595	DNA-templated transcription, initiation
L6172_05045	COG4774	siderophore transport
L6172_05050	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_05065	COG4120	Belongs to the binding-protein-dependent transport system permease family
L6172_05070	COG1122	ATPase activity
L6172_05080	COG2207	Transcriptional regulator
L6172_05100	COG1309	transcriptional regulator
L6172_05105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6172_05110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6172_05115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6172_05115	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L6172_05140	COG2391	methyltransferase activity
L6172_05145	COG0513	Belongs to the DEAD box helicase family
L6172_05150	COG1278	Cold shock
L6172_05165	COG2186	Transcriptional regulator
L6172_05175	COG0765	amino acid transport
L6172_05180	COG0765	amino acid transport
L6172_05195	COG1671	Belongs to the UPF0178 family
L6172_05245	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
L6172_05260	COG0523	cobalamin synthesis protein
L6172_05270	COG0625	glutathione transferase activity
L6172_05275	COG0625	glutathione transferase activity
L6172_05280	COG0477	Major facilitator Superfamily
L6172_05285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6172_05290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L6172_05295	COG1845	cytochrome c oxidase, subunit III
L6172_05300	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L6172_05305	COG3346	SURF1 family
L6172_05315	COG2226	methyltransferase
L6172_05320	COG1309	transcriptional regulator
L6172_05325	COG1970	mechanosensitive ion channel activity
L6172_05335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L6172_05350	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L6172_05350	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L6172_05355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6172_05355	COG4651	solute:proton antiporter activity
L6172_05385	COG3180	Ammonia monooxygenase
L6172_05390	COG1335	isochorismatase
L6172_05415	COG2378	regulation of single-species biofilm formation
L6172_05425	COG3300	MHYT domain
L6172_05425	COG5001	Diguanylate cyclase
L6172_05440	COG1366	Belongs to the anti-sigma-factor antagonist family
L6172_05445	COG2204	response regulator
L6172_05460	COG0784	Response regulator, receiver
L6172_05460	COG5002	protein histidine kinase activity
L6172_05475	COG0584	glycerophosphoryl diester phosphodiesterase
L6172_05480	COG1879	ABC-type sugar transport system periplasmic component
L6172_05485	COG3706	GGDEF domain
L6172_05490	COG0772	Belongs to the SEDS family
L6172_05495	COG0768	penicillin binding
L6172_05520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6172_05525	COG1280	lysine exporter protein (LysE YggA)
L6172_05540	COG3706	GGDEF domain
L6172_05550	COG1278	Cold shock
L6172_05555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L6172_05580	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L6172_05585	COG0840	transmembrane signaling receptor activity
L6172_05600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6172_05600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6172_05610	COG0519	Catalyzes the synthesis of GMP from XMP
L6172_05620	COG2824	Alkylphosphonate utilization operon protein PhnA
L6172_05630	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_05635	COG3655	Transcriptional regulator
L6172_05655	COG0640	Transcriptional regulator
L6172_05685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6172_05690	COG0765	amino acid transport
L6172_05695	COG0765	amino acid transport
L6172_05750	COG1653	transport
L6172_05760	COG0395	ABC-type sugar transport system, permease component
L6172_05775	COG1012	belongs to the aldehyde dehydrogenase family
L6172_05785	COG0596	Alpha beta hydrolase
L6172_05790	COG0494	nUDIX hydrolase
L6172_05795	COG2226	methyltransferase
L6172_05820	COG1653	transport
L6172_05835	COG0366	Alpha amylase catalytic
L6172_05840	COG3842	ATPase activity
L6172_05845	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6172_05850	COG0363	glucosamine-6-phosphate deaminase activity
L6172_05855	COG0129	dihydroxy-acid dehydratase activity
L6172_05860	COG0837	glucose binding
L6172_05865	COG0800	Aldolase
L6172_05890	COG1595	DNA-templated transcription, initiation
L6172_05920	COG0765	amino acid transport
L6172_05925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6172_05945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6172_05955	COG2719	SpoVR family
L6172_05960	COG2718	Belongs to the UPF0229 family
L6172_05965	COG2766	serine protein kinase
L6172_05970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6172_06000	COG0251	oxidation-reduction process
L6172_06005	COG0251	oxidation-reduction process
L6172_06035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6172_06060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6172_06070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L6172_06080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L6172_06085	COG0222	ribosome binding
L6172_06090	COG0085	RNA polymerase activity
L6172_06095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L6172_06110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L6172_06115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L6172_06125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L6172_06130	COG0088	Forms part of the polypeptide exit tunnel
L6172_06135	COG0089	rRNA binding
L6172_06145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L6172_06155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L6172_06160	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L6172_06165	COG0255	Belongs to the universal ribosomal protein uL29 family
L6172_06175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L6172_06180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L6172_06185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L6172_06195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L6172_06200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L6172_06205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L6172_06215	COG1841	ribosomal large subunit assembly
L6172_06220	COG0200	Binds to the 23S rRNA
L6172_06225	COG0201	protein transport
L6172_06230	COG0563	adenylate kinase activity
L6172_06235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L6172_06240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L6172_06250	COG0203	ribosomal protein L17
L6172_06255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6172_06260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L6172_06265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6172_06275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6172_06280	COG0564	pseudouridine synthase activity
L6172_06290	COG0546	phosphoglycolate phosphatase activity
L6172_06305	COG0412	Dienelactone hydrolase
L6172_06310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6172_06340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L6172_06345	COG4770	biotin carboxylase activity
L6172_06360	COG1254	Belongs to the acylphosphatase family
L6172_06380	COG0277	FAD linked oxidase domain protein
L6172_06385	COG0009	L-threonylcarbamoyladenylate synthase
L6172_06420	COG1355	regulation of microtubule-based process
L6172_06430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6172_06430	COG0456	acetyltransferase
L6172_06435	COG0583	DNA-binding transcription factor activity
L6172_06450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L6172_06480	COG2011	ABC-type metal ion transport system permease component
L6172_06500	COG0477	Major facilitator Superfamily
L6172_06525	COG2814	Major facilitator Superfamily
L6172_06540	COG0488	(ABC) transporter
L6172_06545	COG0105	UTP biosynthetic process
L6172_06570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L6172_06575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L6172_06585	COG0628	permease
L6172_06590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L6172_06595	COG0189	ligase activity
L6172_06595	COG4067	protein conserved in archaea
L6172_06600	COG0189	ligase activity
L6172_06610	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L6172_06620	COG0702	epimerase
L6172_06625	COG0583	DNA-binding transcription factor activity
L6172_06635	COG0248	Ppx GppA phosphatase
L6172_06640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L6172_06665	COG0640	Transcriptional regulator
L6172_06670	COG0123	including yeast histone deacetylase and acetoin utilization protein
L6172_06680	COG0142	geranyltranstransferase activity
L6172_06690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L6172_06710	COG0318	PFAM AMP-dependent synthetase and ligase
L6172_06735	COG1802	Transcriptional regulator
L6172_06740	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L6172_06750	COG0583	DNA-binding transcription factor activity
L6172_06790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L6172_06795	COG1295	ribonuclease BN
L6172_06800	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L6172_06800	COG3264	Mechanosensitive ion channel
L6172_06825	COG4520	surface antigen
L6172_06835	COG0640	Transcriptional regulator
L6172_06850	COG2135	peptidase activity
L6172_06855	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_06870	COG0156	8-amino-7-oxononanoate synthase activity
L6172_06875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6172_06895	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6172_06900	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L6172_06910	COG0659	secondary active sulfate transmembrane transporter activity
L6172_06915	COG1024	Enoyl-CoA hydratase
L6172_06915	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6172_06925	COG2814	Major facilitator Superfamily
L6172_06940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L6172_06955	COG4191	Histidine kinase
L6172_06965	COG0583	DNA-binding transcription factor activity
L6172_06970	COG2814	Major facilitator Superfamily
L6172_06975	COG2814	Major facilitator Superfamily
L6172_06985	COG0656	L-ascorbic acid biosynthetic process
L6172_06990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6172_07000	COG1252	NADH dehydrogenase
L6172_07005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6172_07010	COG0583	DNA-binding transcription factor activity
L6172_07015	COG3622	Belongs to the hyi family
L6172_07025	COG2186	Transcriptional regulator
L6172_07035	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L6172_07075	COG3135	benzoate transporter
L6172_07100	COG0483	inositol monophosphate 1-phosphatase activity
L6172_07105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L6172_07110	COG0352	thiamine-phosphate diphosphorylase activity
L6172_07135	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
L6172_07145	COG1692	metallophosphoesterase
L6172_07150	COG0640	Transcriptional regulator
L6172_07170	COG0217	transcriptional regulatory protein
L6172_07180	COG0632	four-way junction helicase activity
L6172_07185	COG2255	four-way junction helicase activity
L6172_07190	COG0824	Thioesterase
L6172_07200	COG0848	biopolymer transport protein
L6172_07215	COG2885	chlorophyll binding
L6172_07225	COG0037	tRNA processing
L6172_07230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L6172_07235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L6172_07250	COG2205	protein histidine kinase activity
L6172_07255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L6172_07260	COG0351	phosphomethylpyrimidine kinase
L6172_07260	COG0352	thiamine-phosphate diphosphorylase activity
L6172_07280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L6172_07290	COG0129	dihydroxy-acid dehydratase activity
L6172_07300	COG0686	Belongs to the AlaDH PNT family
L6172_07305	COG1522	sequence-specific DNA binding
L6172_07315	COG1177	transmembrane transport
L6172_07320	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6172_07325	COG3842	ATPase activity
L6172_07330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L6172_07335	COG0174	glutamine synthetase
L6172_07345	COG4948	Mandelate Racemase Muconate Lactonizing
L6172_07350	COG3706	GGDEF domain
L6172_07375	COG4095	Psort location CytoplasmicMembrane, score
L6172_07380	COG0842	Transport permease protein
L6172_07385	COG0842	Transport permease protein
L6172_07385	COG1129	ABC transporter
L6172_07390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6172_07415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6172_07420	COG0583	DNA-binding transcription factor activity
L6172_07425	COG0277	FAD linked oxidase domain protein
L6172_07425	COG0247	lactate metabolic process
L6172_07430	COG0583	DNA-binding transcription factor activity
L6172_07490	COG1840	ABC-type Fe3 transport system, periplasmic component
L6172_07505	COG3842	ATPase activity
L6172_07510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L6172_07515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6172_07520	COG2076	Multidrug Resistance protein
L6172_07540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6172_07555	COG2194	sulfuric ester hydrolase activity
L6172_07560	COG1309	transcriptional regulator
L6172_07565	COG0432	Pfam Uncharacterised protein family UPF0047
L6172_07600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6172_07620	COG4765	Protein conserved in bacteria
L6172_07625	COG2353	YceI-like domain
L6172_07630	COG3038	cytochrome b561
L6172_07635	COG2353	YceI-like domain
L6172_07645	COG0400	carboxylic ester hydrolase activity
L6172_07650	COG0534	Mate efflux family protein
L6172_07655	COG1522	sequence-specific DNA binding
L6172_07665	COG1959	2 iron, 2 sulfur cluster binding
L6172_07670	COG0513	Belongs to the DEAD box helicase family
L6172_07710	COG2066	Belongs to the glutaminase family
L6172_07715	COG0187	DNA topoisomerase II activity
L6172_07720	COG1607	acyl-coa hydrolase
L6172_07740	COG4608	Belongs to the ABC transporter superfamily
L6172_07745	COG0444	Belongs to the ABC transporter superfamily
L6172_07750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6172_07755	COG0601	transmembrane transport
L6172_07760	COG0747	negative chemotaxis
L6172_07795	COG0469	pyruvate kinase activity
L6172_07820	COG0668	transmembrane transport
L6172_07835	COG1832	CoA-binding protein
L6172_07870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L6172_07875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L6172_07895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L6172_07900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6172_07905	COG0697	spore germination
L6172_07915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L6172_07925	COG1858	cytochrome C peroxidase
L6172_07930	COG2084	Dehydrogenase
L6172_07935	COG3243	poly(R)-hydroxyalkanoic acid synthase
L6172_07945	COG0436	Aminotransferase
L6172_07955	COG1494	fructose-1,6-bisphosphatase
L6172_07960	COG0443	Heat shock 70 kDa protein
L6172_07975	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L6172_07975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L6172_07995	COG2223	nitrite transmembrane transporter activity
L6172_08015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6172_08035	COG1234	tRNA 3'-trailer cleavage
L6172_08045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6172_08065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L6172_08090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6172_08100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L6172_08105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6172_08110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6172_08115	COG1116	anion transmembrane transporter activity
L6172_08125	COG0372	Belongs to the citrate synthase family
L6172_08145	COG0123	including yeast histone deacetylase and acetoin utilization protein
L6172_08190	COG0656	L-ascorbic acid biosynthetic process
L6172_08220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6172_08230	COG0626	cystathionine gamma-synthase activity
L6172_08235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6172_08240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L6172_08255	COG2897	thiosulfate sulfurtransferase activity
L6172_08260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6172_08300	COG1620	l-lactate permease
L6172_08305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6172_08315	COG0583	DNA-binding transcription factor activity
L6172_08320	COG2814	Major facilitator Superfamily
L6172_08330	COG0494	nUDIX hydrolase
L6172_08335	COG3706	GGDEF domain
L6172_08345	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6172_08350	COG0484	heat shock protein binding
L6172_08375	COG1522	sequence-specific DNA binding
L6172_08410	COG0730	response to heat
L6172_08415	COG0425	Belongs to the sulfur carrier protein TusA family
L6172_08420	COG2153	protein acetylation
L6172_08455	COG1067	ATP-dependent peptidase activity
L6172_08465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6172_08470	COG5457	Domain of unknown function (DUF1127)
L6172_08475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6172_08495	COG3273	potassium ion transport
L6172_08495	COG0471	metal ion transport
L6172_08530	COG0564	pseudouridine synthase activity
L6172_08535	COG0564	pseudouridine synthase activity
L6172_08555	COG1846	Transcriptional regulator
L6172_08635	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
L6172_08645	COG4175	Glycine betaine
L6172_08645	COG3448	diguanylate cyclase activity
L6172_08650	COG4176	ABC-type proline glycine betaine transport system permease component
L6172_08655	COG2113	Glycine betaine
L6172_08660	COG4176	ABC-type proline glycine betaine transport system permease component
L6172_08665	COG4175	Glycine betaine
L6172_08685	COG1840	ABC-type Fe3 transport system, periplasmic component
L6172_08690	COG1840	ABC-type Fe3 transport system, periplasmic component
L6172_08700	COG0303	'Molybdopterin
L6172_08705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L6172_08715	COG0438	transferase activity, transferring glycosyl groups
L6172_08750	COG0747	negative chemotaxis
L6172_08755	COG0601	transmembrane transport
L6172_08760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6172_08765	COG2814	Major facilitator Superfamily
L6172_08775	COG2814	Major facilitator Superfamily
L6172_08780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6172_08780	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L6172_08785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6172_08790	COG1393	Belongs to the ArsC family
L6172_08795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6172_08800	COG0405	Gamma-glutamyltransferase
L6172_08820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L6172_08825	COG0793	Belongs to the peptidase S41A family
L6172_08840	COG0557	exoribonuclease II activity
L6172_08845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6172_08850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L6172_08850	COG0758	DNA mediated transformation
L6172_08855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6172_08860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L6172_08885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L6172_08895	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L6172_08905	COG2223	nitrite transmembrane transporter activity
L6172_08920	COG0583	DNA-binding transcription factor activity
L6172_08925	COG1435	thymidine kinase activity
L6172_08940	COG2995	paraquat-inducible protein a
L6172_08945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L6172_08945	COG3008	intermembrane lipid transfer
L6172_08965	COG2814	Major facilitator Superfamily
L6172_09015	COG0174	glutamine synthetase
L6172_09020	COG1012	belongs to the aldehyde dehydrogenase family
L6172_09025	COG1454	alcohol dehydrogenase
L6172_09030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L6172_09030	COG0519	Catalyzes the synthesis of GMP from XMP
L6172_09035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6172_09040	COG0737	Belongs to the 5'-nucleotidase family
L6172_09045	COG1744	ABC transporter substrate-binding protein PnrA-like
L6172_09060	COG1079	Belongs to the binding-protein-dependent transport system permease family
L6172_09065	COG1744	ABC transporter substrate-binding protein PnrA-like
L6172_09070	COG0295	cytidine deaminase activity
L6172_09075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L6172_09080	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L6172_09095	COG0559	Belongs to the binding-protein-dependent transport system permease family
L6172_09100	COG0410	ABC transporter
L6172_09105	COG0411	ABC transporter
L6172_09115	COG0583	DNA-binding transcription factor activity
L6172_09130	COG1126	abc transporter atp-binding protein
L6172_09135	COG0765	amino acid transport
L6172_09140	COG4597	amino acid ABC transporter
L6172_09145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6172_09150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6172_09155	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6172_09185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6172_09215	COG2814	Major facilitator Superfamily
L6172_09240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6172_09250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6172_09260	COG1122	ATPase activity
L6172_09275	COG0310	cobalt ion transport
L6172_09305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6172_09305	COG1042	CoA-binding domain protein
L6172_09305	COG0045	succinate-CoA ligase (ADP-forming) activity
L6172_09340	COG4989	oxidoreductase activity
L6172_09355	COG0840	transmembrane signaling receptor activity
L6172_09360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L6172_09365	COG1054	Belongs to the UPF0176 family
L6172_09370	COG1538	Outer membrane efflux protein
L6172_09380	COG0525	valine-tRNA ligase activity
L6172_09390	COG0512	Glutamine amidotransferase of anthranilate synthase
L6172_09405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L6172_09415	COG0316	Belongs to the HesB IscA family
L6172_09430	COG1472	Belongs to the glycosyl hydrolase 3 family
L6172_09435	COG1994	Peptidase M50
L6172_09440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L6172_09445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L6172_09450	COG3842	ATPase activity
L6172_09455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L6172_09460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L6172_09485	COG4942	peptidase
L6172_09495	COG1862	Preprotein translocase
L6172_09500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6172_09505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6172_09515	COG3737	Protein of unknown function (DUF498/DUF598)
L6172_09520	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6172_09525	COG0668	transmembrane transport
L6172_09550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6172_09555	COG0191	fructose-bisphosphate aldolase activity
L6172_09560	COG0673	inositol 2-dehydrogenase activity
L6172_09565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6172_09570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L6172_09575	COG2188	Transcriptional regulator
L6172_09580	COG2971	BadF BadG BcrA BcrD
L6172_09585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
L6172_09595	COG1175	transmembrane transport
L6172_09605	COG3842	ATPase activity
L6172_09615	COG3842	ATPase activity
L6172_09620	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6172_09625	COG1177	transmembrane transport
L6172_09635	COG1175	transmembrane transport
L6172_09640	COG0395	ABC-type sugar transport system, permease component
L6172_09645	COG3842	ATPase activity
L6172_09650	COG1956	GAF domain-containing protein
L6172_09655	COG0629	single-stranded DNA binding
L6172_09670	COG3012	SEC-C Motif Domain Protein
L6172_09680	COG1051	belongs to the nudix hydrolase family
L6172_09695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L6172_09705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L6172_09715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
L6172_09760	COG2951	lytic endotransglycosylase activity
L6172_09770	COG1686	Belongs to the peptidase S11 family
L6172_09775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L6172_09790	COG0084	hydrolase, TatD family'
L6172_09795	COG0321	lipoyl(octanoyl) transferase activity
L6172_09795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L6172_09810	COG0629	single-stranded DNA binding
L6172_09920	COG1846	Transcriptional regulator
L6172_09930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6172_09935	COG1917	Cupin 2, conserved barrel domain protein
L6172_09940	COG0527	aspartate kinase activity
L6172_09945	COG3956	TIGRFAM MazG family protein
L6172_09950	COG0483	inositol monophosphate 1-phosphatase activity
L6172_09955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6172_09970	COG0569	domain protein
L6172_09975	COG2204	response regulator
L6172_10040	COG0776	regulation of translation
L6172_10050	COG0416	fatty acid biosynthetic process
L6172_10070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L6172_10075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6172_10080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L6172_10085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L6172_10085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L6172_10095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6172_10095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6172_10100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L6172_10110	COG0698	ribose 5-phosphate isomerase
L6172_10155	COG1024	Enoyl-CoA hydratase
L6172_10180	COG0113	porphobilinogen synthase activity
L6172_10185	COG1011	Hydrolase
L6172_10195	COG0318	PFAM AMP-dependent synthetase and ligase
L6172_10205	COG1012	belongs to the aldehyde dehydrogenase family
L6172_10210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6172_10215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L6172_10220	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6172_10225	COG1360	Flagellar Motor Protein
L6172_10235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L6172_10240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_10250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6172_10255	COG1381	Involved in DNA repair and RecF pathway recombination
L6172_10275	COG0571	ribonuclease III activity
L6172_10280	COG0681	Belongs to the peptidase S26 family
L6172_10285	COG0736	holo-[acyl-carrier-protein] synthase activity
L6172_10290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L6172_10320	COG1573	uracil-dna glycosylase
L6172_10325	COG0514	ATP-dependent DNA helicase (RecQ)
L6172_10330	COG0386	Belongs to the glutathione peroxidase family
L6172_10335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L6172_10340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L6172_10345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6172_10350	COG1196	nuclear chromosome segregation
L6172_10350	COG0739	heme binding
L6172_10350	COG0741	lytic transglycosylase activity
L6172_10365	COG0739	heme binding
L6172_10375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L6172_10380	COG1546	Belongs to the CinA family
L6172_10380	COG1058	Belongs to the CinA family
L6172_10385	COG2867	negative regulation of translational initiation
L6172_10390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L6172_10395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6172_10400	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6172_10405	COG0022	dehydrogenase e1 component
L6172_10405	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6172_10410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6172_10415	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L6172_10420	COG0148	phosphopyruvate hydratase activity
L6172_10440	COG0149	triose-phosphate isomerase activity
L6172_10445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6172_10450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L6172_10455	COG2861	carbohydrate metabolic process
L6172_10475	COG0315	cyclic pyranopterin monophosphate synthase activity
L6172_10485	COG2333	competence protein COMEC
L6172_10485	COG0658	competence protein
L6172_10490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L6172_10495	COG0372	Belongs to the citrate synthase family
L6172_10505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L6172_10510	COG3494	Protein of unknown function (DUF1009)
L6172_10525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L6172_10535	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L6172_10540	COG0750	zinc metalloprotease
L6172_10545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L6172_10555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L6172_10570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L6172_10595	COG0442	prolyl-tRNA aminoacylation
L6172_10645	COG0713	ATP synthesis coupled electron transport
L6172_10655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6172_10660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L6172_10665	COG1034	ATP synthesis coupled electron transport
L6172_10670	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L6172_10675	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
L6172_10690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6172_10695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6172_10705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6172_10720	COG0776	regulation of translation
L6172_10735	COG0740	serine-type endopeptidase activity
L6172_10755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L6172_10755	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L6172_10765	COG2202	Pas domain
L6172_10765	COG2205	protein histidine kinase activity
L6172_10780	COG2217	Heavy metal translocating P-type atpase
L6172_10785	COG2193	ferroxidase activity
L6172_10795	COG3046	protein related to deoxyribodipyrimidine photolyase
L6172_10815	COG1175	transmembrane transport
L6172_10820	COG0395	ABC-type sugar transport system, permease component
L6172_10825	COG3842	ATPase activity
L6172_10845	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
L6172_10855	COG0166	Belongs to the GPI family
L6172_10870	COG0010	Belongs to the arginase family
L6172_10875	COG1012	belongs to the aldehyde dehydrogenase family
L6172_10880	COG1917	Cupin 2, conserved barrel domain protein
L6172_10880	COG1396	sequence-specific DNA binding
L6172_10885	COG0174	glutamine synthetase
L6172_10895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6172_10920	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
L6172_10925	COG1012	belongs to the aldehyde dehydrogenase family
L6172_10940	COG4176	ABC-type proline glycine betaine transport system permease component
L6172_10945	COG0517	IMP dehydrogenase activity
L6172_10945	COG4175	Glycine betaine
L6172_10950	COG4175	Glycine betaine
L6172_10960	COG0583	DNA-binding transcription factor activity
L6172_10980	COG3842	ATPase activity
L6172_10985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6172_10990	COG3246	L-lysine catabolic process to acetate
L6172_11005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6172_11010	COG0251	oxidation-reduction process
L6172_11030	COG2423	ornithine cyclodeaminase activity
L6172_11035	COG0657	acetylesterase activity
L6172_11045	COG3616	Alanine racemase, N-terminal domain
L6172_11055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_11060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_11075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6172_11085	COG0729	surface antigen
L6172_11090	COG0189	ligase activity
L6172_11100	COG3453	Protein conserved in bacteria
L6172_11100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6172_11125	COG0183	Belongs to the thiolase family
L6172_11130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L6172_11135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L6172_11140	COG3485	protocatechuate 3,4-dioxygenase
L6172_11145	COG3485	protocatechuate 3,4-dioxygenase
L6172_11150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6172_11155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L6172_11160	COG0583	DNA-binding transcription factor activity
L6172_11190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6172_11225	COG2814	Major facilitator Superfamily
L6172_11235	COG2375	cellular response to nickel ion
L6172_11260	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L6172_11285	COG3769	mannosylglycerate metabolic process
L6172_11290	COG1215	transferase activity, transferring glycosyl groups
L6172_11295	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_11300	COG0583	DNA-binding transcription factor activity
L6172_11315	COG0366	Alpha amylase catalytic
L6172_11325	COG0583	DNA-binding transcription factor activity
L6172_11335	COG0028	Belongs to the TPP enzyme family
L6172_11340	COG1414	Transcriptional regulator
L6172_11355	COG1741	Belongs to the pirin family
L6172_11365	COG1196	nuclear chromosome segregation
L6172_11380	COG2186	Transcriptional regulator
L6172_11385	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6172_11390	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6172_11395	COG1129	ABC transporter
L6172_11400	COG1879	ABC-type sugar transport system periplasmic component
L6172_11405	COG2017	converts alpha-aldose to the beta-anomer
L6172_11425	COG1335	isochorismatase
L6172_11430	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_11440	COG0583	DNA-binding transcription factor activity
L6172_11445	COG4221	oxidoreductase activity
L6172_11455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_11460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_11465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L6172_11470	COG1802	Transcriptional regulator
L6172_11525	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L6172_11540	COG0308	aminopeptidase N
L6172_11575	COG0628	permease
L6172_11585	COG1280	lysine exporter protein (LysE YggA)
L6172_11595	COG2205	protein histidine kinase activity
L6172_11605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L6172_11610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L6172_11625	COG4977	sequence-specific DNA binding
L6172_11650	COG0848	biopolymer transport protein
L6172_11655	COG0848	biopolymer transport protein
L6172_11660	COG0811	peptide transport
L6172_11680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L6172_11685	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6172_11690	COG0697	spore germination
L6172_11715	COG0418	dihydroorotase activity
L6172_11735	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_11755	COG0436	Aminotransferase
L6172_11770	COG0457	Tetratricopeptide repeat
L6172_11780	COG0457	Tetratricopeptide repeat
L6172_11785	COG5002	protein histidine kinase activity
L6172_11785	COG3447	MASE1 domain protein
L6172_11785	COG5001	Diguanylate cyclase
L6172_11795	COG1765	OsmC-like protein
L6172_11820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L6172_11825	COG0457	Tetratricopeptide repeat
L6172_11840	COG1802	Transcriptional regulator
L6172_11845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_11850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_11850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L6172_11855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_11860	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L6172_11865	COG2199	diguanylate cyclase activity
L6172_11865	COG2200	EAL domain
L6172_11865	COG3287	FIST C domain
L6172_11880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6172_11890	COG0583	DNA-binding transcription factor activity
L6172_11920	COG3457	Alanine racemase
L6172_11960	COG0482	sulfurtransferase activity
L6172_11965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6172_11970	COG2975	iron-sulfur cluster assembly
L6172_11975	COG0633	Ferredoxin
L6172_11990	COG0316	Belongs to the HesB IscA family
L6172_11995	COG0822	iron-sulfur transferase activity
L6172_12000	COG1104	cysteine desulfurase activity
L6172_12005	COG1104	cysteine desulfurase activity
L6172_12010	COG1959	2 iron, 2 sulfur cluster binding
L6172_12015	COG1045	serine acetyltransferase
L6172_12020	COG2945	thiolester hydrolase activity
L6172_12025	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L6172_12040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L6172_12045	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L6172_12055	COG2833	Protein of unknown function (DUF455)
L6172_12065	COG0625	glutathione transferase activity
L6172_12115	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6172_12120	COG1530	ribonuclease E activity
L6172_12125	COG0436	Aminotransferase
L6172_12160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L6172_12165	COG0511	ligase activity, forming carbon-carbon bonds
L6172_12170	COG0439	Biotin carboxylase
L6172_12175	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L6172_12190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6172_12200	COG0840	transmembrane signaling receptor activity
L6172_12220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L6172_12235	COG1686	Belongs to the peptidase S11 family
L6172_12245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L6172_12255	COG0484	heat shock protein binding
L6172_12280	COG2342	PFAM TM1410 hypothetical-related protein
L6172_12330	COG1522	sequence-specific DNA binding
L6172_12340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L6172_12345	COG1024	Enoyl-CoA hydratase
L6172_12365	COG0840	transmembrane signaling receptor activity
L6172_12385	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6172_12400	COG0583	DNA-binding transcription factor activity
L6172_12415	COG2084	Dehydrogenase
L6172_12420	COG0793	Belongs to the peptidase S41A family
L6172_12425	COG1960	acyl-CoA dehydrogenase activity
L6172_12430	COG0795	lipopolysaccharide-transporting ATPase activity
L6172_12440	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L6172_12445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6172_12455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L6172_12460	COG0194	GDP metabolic process
L6172_12465	COG1561	YicC-like family, N-terminal region
L6172_12475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L6172_12480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6172_12495	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L6172_12505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L6172_12515	COG0359	binds to the 23S rRNA
L6172_12520	COG0305	Participates in initiation and elongation during chromosome replication
L6172_12525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6172_12530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L6172_12535	COG1127	ABC transporter
L6172_12550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L6172_12555	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_12560	COG0583	DNA-binding transcription factor activity
L6172_12565	COG0667	Aldo Keto reductase
L6172_12570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6172_12575	COG1160	GTP binding
L6172_12580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L6172_12605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6172_12610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L6172_12610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6172_12620	COG4993	Dehydrogenase
L6172_12625	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6172_12630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6172_12635	COG0071	Belongs to the small heat shock protein (HSP20) family
L6172_12640	COG1902	pentaerythritol trinitrate reductase activity
L6172_12650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L6172_12655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L6172_12660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L6172_12665	COG0546	phosphoglycolate phosphatase activity
L6172_12675	COG0129	dihydroxy-acid dehydratase activity
L6172_12680	COG4214	carbohydrate transport
L6172_12690	COG4213	ABC transporter substrate-binding protein
L6172_12705	COG0237	dephospho-CoA kinase activity
L6172_12715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6172_12730	COG1234	tRNA 3'-trailer cleavage
L6172_12740	COG4149	molybdate abc transporter
L6172_12745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L6172_12820	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L6172_12845	COG1283	sodium-dependent phosphate transmembrane transporter activity
L6172_12860	COG0367	asparagine synthase
L6172_12865	COG1522	sequence-specific DNA binding
L6172_12870	COG3284	Transcriptional regulator
L6172_12875	COG1012	belongs to the aldehyde dehydrogenase family
L6172_12895	COG2855	membrane
L6172_12900	COG0583	DNA-binding transcription factor activity
L6172_12905	COG1271	oxidase subunit
L6172_12910	COG1294	oxidase, subunit
L6172_12925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6172_12940	COG1012	belongs to the aldehyde dehydrogenase family
L6172_12945	COG3724	N-succinylarginine dihydrolase activity
L6172_12950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6172_12955	COG1522	sequence-specific DNA binding
L6172_12960	COG0175	sulfate reduction
L6172_12985	COG0587	DNA-directed DNA polymerase activity
L6172_13000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6172_13000	COG1116	anion transmembrane transporter activity
L6172_13010	COG2223	nitrite transmembrane transporter activity
L6172_13015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6172_13020	COG2146	nitrite reductase [NAD(P)H] activity
L6172_13025	COG0243	molybdopterin cofactor binding
L6172_13030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6172_13030	COG1648	precorrin-2 dehydrogenase activity
L6172_13035	COG0583	DNA-binding transcription factor activity
L6172_13060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L6172_13075	COG2827	Endonuclease containing a URI domain
L6172_13080	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_13085	COG0800	Aldolase
L6172_13090	COG3734	2-keto-3-deoxy-galactonokinase
L6172_13110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6172_13115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6172_13125	COG2086	electron transfer activity
L6172_13170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6172_13175	COG2814	Major facilitator Superfamily
L6172_13180	COG4264	IucA IucC family
L6172_13190	COG4264	IucA IucC family
L6172_13195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6172_13200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6172_13205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6172_13210	COG1120	ATPase activity
L6172_13220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6172_13235	COG0405	Gamma-glutamyltransferase
L6172_13240	COG4608	Belongs to the ABC transporter superfamily
L6172_13245	COG0444	Belongs to the ABC transporter superfamily
L6172_13250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6172_13260	COG0747	negative chemotaxis
L6172_13265	COG1414	Transcriptional regulator
L6172_13275	COG0348	domain, Protein
L6172_13275	COG3901	Regulator of nitric oxide reductase transcription
L6172_13355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6172_13360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6172_13365	COG0438	transferase activity, transferring glycosyl groups
L6172_13380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L6172_13405	COG3842	ATPase activity
L6172_13410	COG3842	ATPase activity
L6172_13420	COG0395	ABC-type sugar transport system, permease component
L6172_13465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6172_13470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6172_13485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6172_13490	COG1309	transcriptional regulator
L6172_13510	COG0493	'glutamate synthase
L6172_13515	COG1522	sequence-specific DNA binding
L6172_13525	COG1115	amino acid carrier protein
L6172_13530	COG0826	peptidase U32
L6172_13545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6172_13570	COG1120	ATPase activity
L6172_13585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6172_13595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6172_13610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_13615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6172_13635	COG2017	converts alpha-aldose to the beta-anomer
L6172_13640	COG2186	Transcriptional regulator
L6172_13645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6172_13650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L6172_13665	COG0129	dihydroxy-acid dehydratase activity
L6172_13670	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_13675	COG4213	ABC transporter substrate-binding protein
L6172_13680	COG4214	carbohydrate transport
L6172_13695	COG1940	carbohydrate kinase activity
L6172_13700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6172_13710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6172_13735	COG1609	Transcriptional regulator
L6172_13740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6172_13750	COG3383	formate dehydrogenase (NAD+) activity
L6172_13765	COG0583	DNA-binding transcription factor activity
L6172_13770	COG2223	nitrite transmembrane transporter activity
L6172_13775	COG4191	Histidine kinase
L6172_13780	COG2204	response regulator
L6172_13815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6172_13820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6172_13830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6172_13840	COG2986	histidine ammonia-lyase
L6172_13870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6172_13880	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_13885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6172_13905	COG1129	ABC transporter
L6172_13925	COG3483	tryptophan 2,3-dioxygenase activity
L6172_13940	COG1960	acyl-CoA dehydrogenase activity
L6172_13975	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6172_13975	COG1024	Enoyl-CoA hydratase
L6172_13990	COG0673	inositol 2-dehydrogenase activity
L6172_13995	COG3718	enzyme involved in inositol metabolism
L6172_14005	COG3962	Belongs to the TPP enzyme family
L6172_14010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6172_14055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6172_14070	COG3597	protein domain associated with
L6172_14085	COG3597	protein domain associated with
L6172_14115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6172_14140	COG4948	Mandelate Racemase Muconate Lactonizing
L6172_14145	COG0583	DNA-binding transcription factor activity
L6172_14150	COG0473	3-isopropylmalate dehydrogenase activity
L6172_14170	COG3181	Tripartite tricarboxylate transporter family receptor
L6172_14175	COG0583	DNA-binding transcription factor activity
L6172_14180	COG1132	(ABC) transporter
L6172_14185	COG1120	ATPase activity
L6172_14220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6172_14225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_14245	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6172_14260	COG0420	3'-5' exonuclease activity
L6172_14265	COG4717	serine-type aminopeptidase activity
L6172_14290	COG2948	multi-organism process
L6172_14315	COG3451	type IV secretory pathway VirB4
L6172_14330	COG4962	Type ii secretion system protein e
L6172_14345	COG0084	hydrolase, TatD family'
L6172_14370	COG0739	heme binding
L6172_14370	COG1196	nuclear chromosome segregation
L6172_14370	COG0741	lytic transglycosylase activity
L6172_14375	COG0681	Belongs to the peptidase S26 family
L6172_14405	COG1475	DNA binding
L6172_14415	COG4227	nucleotidyltransferase activity
L6172_14460	COG0784	Response regulator, receiver
L6172_14460	COG4191	Histidine kinase
L6172_14470	COG0745	RESPONSE REGULATOR receiver
L6172_14475	COG0784	Response regulator, receiver
L6172_14475	COG4191	Histidine kinase
L6172_14485	COG1349	DNA-binding transcription factor activity
L6172_14515	COG1129	ABC transporter
L6172_14520	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6172_14535	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L6172_14540	COG0698	ribose 5-phosphate isomerase
L6172_14550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L6172_14555	COG4952	isomerase
L6172_14560	COG4952	isomerase
L6172_14565	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_14565	COG3347	Dehydrogenase
L6172_14580	COG1129	ABC transporter
L6172_14590	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6172_14595	COG3254	rhamnose metabolic process
L6172_14745	COG2205	protein histidine kinase activity
L6172_14765	COG1104	cysteine desulfurase activity
L6172_14815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6172_14840	COG0789	Transcriptional regulator
L6172_14865	COG0785	Cytochrome C biogenesis protein
L6172_14880	COG1999	signal sequence binding
L6172_14895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6172_14900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6172_14940	COG2132	Multicopper oxidase
L6172_15015	COG1192	Involved in chromosome partitioning
L6172_15075	COG0739	heme binding
L6172_15075	COG1196	nuclear chromosome segregation
L6172_15075	COG0741	lytic transglycosylase activity
L6172_15080	COG0583	DNA-binding transcription factor activity
L6172_15085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6172_15090	COG4597	amino acid ABC transporter
L6172_15095	COG0765	amino acid transport
L6172_15100	COG1126	abc transporter atp-binding protein
L6172_15110	COG1132	(ABC) transporter
L6172_15115	COG1965	Belongs to the frataxin family
L6172_15120	COG0254	rRNA binding
L6172_15140	COG0604	alcohol dehydrogenase
L6172_15140	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_15140	COG3321	synthase
L6172_15155	COG1349	DNA-binding transcription factor activity
L6172_15160	COG0583	DNA-binding transcription factor activity
L6172_15210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L6172_15215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L6172_15230	COG0242	peptide deformylase activity
L6172_15235	COG1566	PFAM secretion protein HlyD family protein
L6172_15245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L6172_15255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_15265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_15270	COG2056	Na+-H+ antiporter family
L6172_15300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L6172_15325	COG0542	response to heat
L6172_15345	COG2890	protein-(glutamine-N5) methyltransferase activity
L6172_15350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L6172_15355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L6172_15360	COG0124	histidyl-tRNA synthetase
L6172_15365	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L6172_15375	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
L6172_15380	COG2070	2-Nitropropane dioxygenase
L6172_15390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6172_15400	COG2813	Specifically methylates the guanine in position
L6172_15455	COG2070	2-Nitropropane dioxygenase
L6172_15465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L6172_15470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L6172_15475	COG0583	DNA-binding transcription factor activity
L6172_15480	COG0625	glutathione transferase activity
L6172_15485	COG1017	nitric oxide dioxygenase activity
L6172_15485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6172_15495	COG1489	DNA binding
L6172_15500	COG0024	Methionine aminopeptidase
L6172_15505	COG2003	Belongs to the UPF0758 family
L6172_15520	COG0583	DNA-binding transcription factor activity
L6172_15540	COG4166	transmembrane transport
L6172_15545	COG0601	transmembrane transport
L6172_15550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6172_15570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6172_15570	COG2169	Transcriptional regulator
L6172_15575	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_15580	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L6172_15585	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L6172_15590	COG0583	DNA-binding transcription factor activity
L6172_15595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L6172_15610	COG0504	CTP synthase activity
L6172_15615	COG2197	response regulator
L6172_15630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L6172_15635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L6172_15640	COG0047	phosphoribosylformylglycinamidine synthase activity
L6172_15645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L6172_15665	COG0489	protein tyrosine kinase activity
L6172_15670	COG0330	HflC and HflK could
L6172_15690	COG3830	Belongs to the UPF0237 family
L6172_15690	COG0560	Phosphoserine phosphatase
L6172_15700	COG0028	Belongs to the TPP enzyme family
L6172_15705	COG0440	acetolactate synthase activity
L6172_15710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6172_15715	COG2313	pseudouridylate synthase activity
L6172_15730	COG0415	Belongs to the DNA photolyase family
L6172_15760	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L6172_15765	COG1530	ribonuclease E activity
L6172_15785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L6172_15795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L6172_15840	COG2197	response regulator
L6172_15850	COG0604	alcohol dehydrogenase
L6172_15855	COG3339	Conserved Protein
L6172_15875	COG0354	folic acid binding
L6172_15880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L6172_15880	COG0574	Belongs to the PEP-utilizing enzyme family
L6172_15890	COG0752	glycyl-tRNA synthetase alpha subunit
L6172_15900	COG2890	protein-(glutamine-N5) methyltransferase activity
L6172_15910	COG0142	geranyltranstransferase activity
L6172_15925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L6172_15945	COG3474	cytochrome
L6172_15955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L6172_15975	COG2358	TRAP transporter, solute receptor (TAXI family
L6172_15980	COG3246	L-lysine catabolic process to acetate
L6172_15985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6172_15995	COG0784	Response regulator, receiver
L6172_15995	COG2205	protein histidine kinase activity
L6172_15995	COG5002	protein histidine kinase activity
L6172_16000	COG0367	asparagine synthase
L6172_16015	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L6172_16020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L6172_16040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L6172_16050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L6172_16055	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L6172_16060	COG0306	phosphate transporter
L6172_16065	COG2982	Protein involved in outer membrane biogenesis
L6172_16135	COG0277	FAD linked oxidase domain protein
L6172_16145	COG3119	arylsulfatase activity
L6172_16160	COG0559	Belongs to the binding-protein-dependent transport system permease family
L6172_16185	COG0069	glutamate synthase activity
L6172_16205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_16225	COG0840	transmembrane signaling receptor activity
L6172_16235	COG0488	(ABC) transporter
L6172_16245	COG3023	N-Acetylmuramoyl-L-alanine amidase
L6172_16265	COG1335	isochorismatase
L6172_16270	COG4977	sequence-specific DNA binding
L6172_16285	COG2001	Belongs to the MraZ family
L6172_16290	COG0275	rRNA processing
L6172_16305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6172_16320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L6172_16335	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
L6172_16345	COG0640	Transcriptional regulator
L6172_16355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L6172_16355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L6172_16370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L6172_16380	COG1181	Belongs to the D-alanine--D-alanine ligase family
L6172_16385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L6172_16390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6172_16415	COG4948	Mandelate Racemase Muconate Lactonizing
L6172_16420	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_16425	COG1063	alcohol dehydrogenase
L6172_16435	COG3842	ATPase activity
L6172_16445	COG1175	transmembrane transport
L6172_16450	COG1653	transport
L6172_16455	COG0849	cell division
L6172_16460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L6172_16470	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L6172_16480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L6172_16495	COG0697	spore germination
L6172_16505	COG0667	Aldo Keto reductase
L6172_16510	COG0006	proline dipeptidase activity
L6172_16520	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_16525	COG0730	response to heat
L6172_16530	COG2264	protein methyltransferase activity
L6172_16535	COG0210	DNA helicase
L6172_16545	COG0038	chloride channel
L6172_16550	COG2814	Major facilitator Superfamily
L6172_16555	COG0646	methionine synthase
L6172_16555	COG1410	methionine synthase
L6172_16570	COG2226	methyltransferase
L6172_16575	COG2853	Lipoprotein
L6172_16585	COG0488	(ABC) transporter
L6172_16595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6172_16615	COG0725	ABC transporter, periplasmic molybdate-binding protein
L6172_16620	COG4149	molybdate abc transporter
L6172_16625	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L6172_16635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6172_16650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L6172_16650	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6172_16705	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
L6172_16710	COG1609	Transcriptional regulator
L6172_16715	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_16735	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
L6172_16740	COG0473	3-isopropylmalate dehydrogenase activity
L6172_16775	COG0431	NADPH-dependent FMN reductase
L6172_16775	COG1053	succinate dehydrogenase
L6172_16775	COG3976	FMN-binding domain protein
L6172_16780	COG1802	Transcriptional regulator
L6172_16785	COG0745	RESPONSE REGULATOR receiver
L6172_16790	COG2205	protein histidine kinase activity
L6172_16795	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L6172_16800	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L6172_16805	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L6172_16815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L6172_16825	COG0358	DNA primase activity
L6172_16840	COG0505	Belongs to the CarA family
L6172_16845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L6172_16850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L6172_16860	COG1522	sequence-specific DNA binding
L6172_16865	COG0492	ferredoxin-NADP+ reductase activity
L6172_16870	COG0583	DNA-binding transcription factor activity
L6172_16875	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L6172_16880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L6172_16885	COG0783	Belongs to the Dps family
L6172_16890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L6172_16910	COG0154	amidase activity
L6172_16935	COG4336	lyase activity
L6172_16940	COG0583	DNA-binding transcription factor activity
L6172_16945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L6172_16960	COG0556	nucleotide-excision repair
L6172_16965	COG0436	Aminotransferase
L6172_16975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6172_16980	COG0450	alkyl hydroperoxide reductase
L6172_16985	COG0583	DNA-binding transcription factor activity
L6172_16995	COG1063	alcohol dehydrogenase
L6172_17000	COG4459	periplasmic nitrate reductase
L6172_17005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6172_17005	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
L6172_17020	COG3043	anaerobic respiration
L6172_17025	COG3005	denitrification pathway
L6172_17030	COG1618	nucleotide phosphatase activity, acting on free nucleotides
L6172_17030	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L6172_17035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L6172_17035	COG0519	Catalyzes the synthesis of GMP from XMP
L6172_17040	COG0012	GTP binding
L6172_17050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L6172_17055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L6172_17110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6172_17140	COG0745	RESPONSE REGULATOR receiver
L6172_17145	COG1846	Transcriptional regulator
L6172_17150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6172_17155	COG0625	glutathione transferase activity
L6172_17160	COG0408	coproporphyrinogen oxidase activity
L6172_17165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L6172_17195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6172_17220	COG1072	(Pantothenic acid kinase))
L6172_17225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6172_17240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6172_17270	COG2132	Multicopper oxidase
L6172_17280	COG1522	sequence-specific DNA binding
L6172_17305	COG1396	sequence-specific DNA binding
L6172_17320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L6172_17325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L6172_17330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L6172_17375	COG0438	transferase activity, transferring glycosyl groups
L6172_17385	COG0367	asparagine synthase
L6172_17395	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6172_17400	COG1121	(ABC) transporter
L6172_17405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6172_17405	COG1321	iron dependent repressor
L6172_17410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6172_17430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6172_17435	COG1360	Flagellar Motor Protein
L6172_17445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L6172_17450	COG0612	Peptidase, M16
L6172_17455	COG0612	Peptidase, M16
L6172_17465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L6172_17475	COG0196	riboflavin kinase activity
L6172_17485	COG2030	dehydratase
L6172_17490	COG2226	methyltransferase
L6172_17505	COG5001	Diguanylate cyclase
L6172_17505	COG3300	MHYT domain
L6172_17540	COG0737	Belongs to the 5'-nucleotidase family
L6172_17550	COG2207	Transcriptional regulator
L6172_17565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6172_17570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L6172_17575	COG1960	acyl-CoA dehydrogenase activity
L6172_17580	COG0583	DNA-binding transcription factor activity
L6172_17595	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L6172_17715	COG3829	transcription factor binding
L6172_17810	COG0583	DNA-binding transcription factor activity
L6172_17815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6172_17820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6172_17850	COG1012	belongs to the aldehyde dehydrogenase family
L6172_17865	COG0683	leucine binding
L6172_17885	COG0028	Belongs to the TPP enzyme family
L6172_17890	COG1053	succinate dehydrogenase
L6172_17900	COG1053	succinate dehydrogenase
L6172_17900	COG3976	FMN-binding domain protein
L6172_17910	COG0028	Belongs to the TPP enzyme family
L6172_17925	COG3180	Ammonia monooxygenase
L6172_17930	COG1802	Transcriptional regulator
L6172_17965	COG0501	Belongs to the peptidase M48B family
L6172_17990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6172_17990	COG2205	protein histidine kinase activity
L6172_18000	COG4251	negative regulation of phosphorylation
L6172_18010	COG2832	Protein of unknown function (DUF454)
L6172_18040	COG1320	monovalent cation:proton antiporter activity
L6172_18045	COG2212	antiporter activity
L6172_18050	COG1863	multisubunit Na H antiporter MnhE subunit
L6172_18055	COG0651	ATP synthesis coupled electron transport
L6172_18060	COG1006	Multisubunit Na H antiporter MnhC subunit
L6172_18065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6172_18065	COG2111	Na H antiporter
L6172_18075	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L6172_18120	COG0733	neurotransmitter:sodium symporter activity
L6172_18135	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6172_18140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6172_18145	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6172_18150	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L6172_18155	COG1138	Cytochrome C-type biogenesis protein
L6172_18160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6172_18165	COG3088	subunit of a heme lyase
L6172_18170	COG3088	subunit of a heme lyase
L6172_18170	COG4235	cytochrome complex assembly
L6172_18175	COG1349	DNA-binding transcription factor activity
L6172_18180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L6172_18190	COG1129	ABC transporter
L6172_18195	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6172_18200	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6172_18220	COG0739	heme binding
L6172_18220	COG1196	nuclear chromosome segregation
L6172_18220	COG0741	lytic transglycosylase activity
L6172_18225	COG1573	uracil-dna glycosylase
L6172_18235	COG1012	belongs to the aldehyde dehydrogenase family
L6172_18245	COG0583	DNA-binding transcription factor activity
L6172_18260	COG1473	amidohydrolase
L6172_18290	COG3142	Participates in the control of copper homeostasis
L6172_18295	COG1940	carbohydrate kinase activity
L6172_18300	COG0612	Peptidase, M16
L6172_18310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6172_18335	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
L6172_18345	COG0109	protoheme IX farnesyltransferase activity
L6172_18350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L6172_18355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6172_18365	COG1678	Uncharacterized ACR, COG1678
L6172_18370	COG4232	protein-disulfide reductase activity
L6172_18375	COG0678	peroxiredoxin activity
L6172_18375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L6172_18390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L6172_18395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L6172_18400	COG0509	glycine decarboxylation via glycine cleavage system
L6172_18405	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L6172_18415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L6172_18425	COG0328	RNA-DNA hybrid ribonuclease activity
L6172_18440	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_18445	COG1309	transcriptional regulator
L6172_18455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L6172_18455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L6172_18460	COG0604	alcohol dehydrogenase
L6172_18475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6172_18480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L6172_18485	COG0625	glutathione transferase activity
L6172_18490	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
L6172_18495	COG1116	anion transmembrane transporter activity
L6172_18500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6172_18505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6172_18510	COG3604	Transcriptional regulator
L6172_18520	COG2096	Adenosyltransferase
L6172_18535	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6172_18540	COG1070	Carbohydrate kinase
L6172_18545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6172_18550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6172_18565	COG0019	diaminopimelate decarboxylase activity
L6172_18580	COG2884	Cell division ATP-binding protein ftsE
L6172_18610	COG0697	spore germination
L6172_18615	COG0287	Prephenate dehydrogenase
L6172_18630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L6172_18635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L6172_18635	COG2813	Specifically methylates the guanine in position
L6172_18655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L6172_18665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L6172_18670	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_18685	COG0745	RESPONSE REGULATOR receiver
L6172_18700	COG0581	inorganic phosphate transmembrane transporter activity
L6172_18705	COG0573	inorganic phosphate transmembrane transporter activity
L6172_18710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6172_18720	COG0247	lactate metabolic process
L6172_18725	COG0277	FAD linked oxidase domain protein
L6172_18730	COG0277	FAD linked oxidase domain protein
L6172_18735	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L6172_18740	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L6172_18755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6172_18765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L6172_18780	COG0747	negative chemotaxis
L6172_18820	COG1968	undecaprenyl-diphosphatase activity
L6172_18825	COG0640	Transcriptional regulator
L6172_18835	COG0740	serine-type endopeptidase activity
L6172_18860	COG0778	Nitroreductase
L6172_18875	COG1058	Belongs to the CinA family
L6172_18875	COG1546	Belongs to the CinA family
L6172_18910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6172_18915	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L6172_18925	COG1639	'signal transduction protein
L6172_18935	COG0745	RESPONSE REGULATOR receiver
L6172_18935	COG2205	protein histidine kinase activity
L6172_18935	COG4191	Histidine kinase
L6172_18940	COG1609	Transcriptional regulator
L6172_18945	COG1653	transport
L6172_18955	COG0395	ABC-type sugar transport system, permease component
L6172_18960	COG3507	Belongs to the glycosyl hydrolase 43 family
L6172_18980	COG1742	UPF0060 membrane protein
L6172_18990	COG1522	sequence-specific DNA binding
L6172_18995	COG3186	Phenylalanine-4-hydroxylase
L6172_19015	COG1703	isobutyryl-CoA mutase activity
L6172_19030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6172_19060	COG0501	Belongs to the peptidase M48B family
L6172_19070	COG2095	MarC family integral membrane protein
L6172_19075	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L6172_19075	COG0617	tRNA 3'-terminal CCA addition
L6172_19075	COG3620	sequence-specific DNA binding
L6172_19090	COG1518	maintenance of DNA repeat elements
L6172_19115	COG1028	Short-chain dehydrogenase reductase Sdr
L6172_19125	COG0583	DNA-binding transcription factor activity
L6172_19130	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L6172_19140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6172_19145	COG1122	ATPase activity
L6172_19150	COG1268	BioY protein
L6172_19155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L6172_19160	COG0830	nickel cation binding
L6172_19165	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
L6172_19170	COG0804	urea catabolic process
L6172_19175	COG0832	Belongs to the urease beta subunit family
L6172_19180	COG0831	urea catabolic process
L6172_19185	COG0829	nickel cation binding
L6172_19195	COG0411	ABC transporter
L6172_19230	COG0583	DNA-binding transcription factor activity
L6172_19245	COG0840	transmembrane signaling receptor activity
L6172_19270	COG3845	ABC transporter
L6172_19275	COG0590	tRNA wobble adenosine to inosine editing
L6172_19285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L6172_19305	COG3648	Uricase
L6172_19305	COG3195	allantoin biosynthetic process
L6172_19310	COG4266	Belongs to the allantoicase family
L6172_19320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6172_19335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L6172_19355	COG2030	dehydratase
L6172_19360	COG2301	Belongs to the HpcH HpaI aldolase family
L6172_19415	COG1842	Phage shock protein A
L6172_19420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L6172_19430	COG1960	acyl-CoA dehydrogenase activity
L6172_19440	COG0183	Belongs to the thiolase family
L6172_19445	COG1960	acyl-CoA dehydrogenase activity
L6172_19460	COG0513	Belongs to the DEAD box helicase family
L6172_19470	COG0077	Prephenate dehydratase
L6172_19470	COG1605	Chorismate mutase
L6172_19475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L6172_19480	COG3474	cytochrome
L6172_19510	COG3263	regulation of cellular component size
L6172_19515	COG1522	sequence-specific DNA binding
L6172_19540	COG2154	pterin-4-alpha-carbinolamine dehydratase
L6172_19545	COG1573	uracil-dna glycosylase
L6172_19555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L6172_19575	COG4172	Belongs to the ABC transporter superfamily
L6172_19580	COG4239	(ABC) transporter, permease
L6172_19585	COG4174	ABC transporter (Permease)
L6172_19590	COG4166	transmembrane transport
L6172_19595	COG0583	DNA-binding transcription factor activity
L6172_19650	COG0693	protein deglycase activity
L6172_19655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_19665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L6172_19685	COG4175	Glycine betaine
L6172_19690	COG4176	ABC-type proline glycine betaine transport system permease component
L6172_19700	COG2986	histidine ammonia-lyase
L6172_19705	COG1228	amidohydrolase
L6172_19715	COG2188	Transcriptional regulator
L6172_19720	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
L6172_19725	COG1741	Belongs to the pirin family
L6172_19730	COG0667	Aldo Keto reductase
L6172_19750	COG4181	ATPase activity
L6172_19755	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L6172_19760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6172_19770	COG0670	Belongs to the BI1 family
L6172_19780	COG0501	Belongs to the peptidase M48B family
L6172_19790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6172_19800	COG2902	Dehydrogenase
L6172_19805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L6172_19835	COG3118	belongs to the thioredoxin family
L6172_19845	COG2835	tetraacyldisaccharide 4'-kinase activity
L6172_19855	COG3047	cAMP biosynthetic process
L6172_19860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6172_19875	COG0004	ammonium transporteR
L6172_19880	COG0004	ammonium transporteR
L6172_19905	COG1074	ATP-dependent DNA helicase activity
L6172_19915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L6172_19925	COG0802	atpase or kinase
L6172_19950	COG1733	regulation of RNA biosynthetic process
L6172_19955	COG4702	Belongs to the UPF0303 family
L6172_19960	COG0481	GTPase activity
L6172_19965	COG4251	negative regulation of phosphorylation
L6172_19975	COG0072	phenylalanine-tRNA ligase activity
L6172_19980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L6172_19985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L6172_19990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L6172_20000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L6172_20035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L6172_20045	COG0181	hydroxymethylbilane synthase activity
L6172_20070	COG0138	bifunctional purine biosynthesis protein purh
L6172_20080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L6172_20085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6172_20085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6172_20090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L6172_20095	COG0243	molybdopterin cofactor binding
L6172_20110	COG2183	response to ionizing radiation
L6172_20120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6172_20135	COG1012	belongs to the aldehyde dehydrogenase family
L6172_20155	COG0583	DNA-binding transcription factor activity
L6172_20160	COG0840	transmembrane signaling receptor activity
L6172_20165	COG2807	transmembrane transport
L6172_20180	COG4520	surface antigen
L6172_20195	COG2067	long-chain fatty acid transport protein
L6172_20210	COG0183	Belongs to the thiolase family
L6172_20215	COG1024	Enoyl-CoA hydratase
L6172_20215	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6172_20220	COG1960	acyl-CoA dehydrogenase activity
L6172_20230	COG1024	Enoyl-CoA hydratase
L6172_20235	COG0300	oxidoreductase activity
L6172_20245	COG2943	transferase activity, transferring hexosyl groups
L6172_20280	COG0730	response to heat
L6172_20285	COG2186	Transcriptional regulator
L6172_20295	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6172_20310	COG3842	ATPase activity
L6172_20355	COG0583	DNA-binding transcription factor activity
L6172_20360	COG1741	Belongs to the pirin family
L6172_20385	COG2204	response regulator
L6172_20415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L6172_20425	COG3181	Tripartite tricarboxylate transporter family receptor
L6172_20445	COG3180	Ammonia monooxygenase
L6172_20450	COG3181	Tripartite tricarboxylate transporter family receptor
L6172_20480	COG0028	Belongs to the TPP enzyme family
L6172_20505	COG1131	(ABC) transporter
L6172_20515	COG0133	tryptophan synthase activity
L6172_20525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L6172_20530	COG0285	dihydrofolate synthase activity
L6172_20540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6172_20540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6172_20545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L6172_20550	COG0667	Aldo Keto reductase
L6172_20555	COG0583	DNA-binding transcription factor activity
L6172_20575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L6172_20585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L6172_20615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6172_20620	COG1217	gtp-binding protein TYPA
L6172_20630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6172_20635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L6172_20640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L6172_20645	COG1137	ATPase activity
L6172_20665	COG0517	IMP dehydrogenase activity
L6172_20665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L6172_20690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6172_20695	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L6172_20700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L6172_20705	COG1420	regulation of RNA biosynthetic process
L6172_20710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L6172_20750	COG0583	DNA-binding transcription factor activity
L6172_20765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L6172_20780	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L6172_20785	COG2992	FlgJ-related protein
L6172_20800	COG0281	malic enzyme
L6172_20800	COG0280	phosphate acetyltransferase
L6172_20810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L6172_20820	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L6172_20835	COG0180	Tryptophanyl-tRNA synthetase
L6172_20850	COG0745	RESPONSE REGULATOR receiver
L6172_20885	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
L6172_20925	COG0445	tRNA wobble uridine modification
L6172_20930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L6172_20945	COG1331	Highly conserved protein containing a thioredoxin domain
L6172_20975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L6172_21000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6172_21005	COG0237	dephospho-CoA kinase activity
L6172_21015	COG0424	maF-like protein
L6172_21020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L6172_21035	COG1981	membrane
L6172_21040	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
L6172_21045	COG3030	protein affecting phage T7 exclusion by the F plasmid
L6172_21050	COG4395	Tim44
L6172_21125	COG1846	Transcriptional regulator
L6172_21155	COG1396	sequence-specific DNA binding
L6172_21160	COG3429	Glucose-6-phosphate dehydrogenase subunit
L6172_21160	COG3409	Peptidoglycan-binding domain 1 protein
L6172_21195	COG0840	transmembrane signaling receptor activity
L6172_21200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L6172_21205	COG2358	TRAP transporter, solute receptor (TAXI family
L6172_21305	COG5654	RES domain protein
L6172_21310	COG5642	Protein of unknown function (DUF2384)
L6172_21325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L6172_21375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L6172_21405	COG0583	DNA-binding transcription factor activity
L6172_21410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6172_21455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L6172_21465	COG0131	Imidazoleglycerol-phosphate dehydratase
L6172_21470	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L6172_21475	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L6172_21485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L6172_21490	COG5002	protein histidine kinase activity
L6172_21505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6172_21510	COG0756	dUTP diphosphatase activity
L6172_21515	COG1959	2 iron, 2 sulfur cluster binding
L6172_21525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6172_21535	COG1280	lysine exporter protein (LysE YggA)
L6172_21545	COG1285	pathogenesis
L6172_21550	COG1609	Transcriptional regulator
L6172_21555	COG2723	6-phospho-beta-galactosidase activity
L6172_21560	COG1653	transport
L6172_21565	COG1175	transmembrane transport
L6172_21580	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
L6172_21620	COG1702	phosphate starvation-inducible protein PhoH
L6172_21630	COG1253	flavin adenine dinucleotide binding
L6172_21635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L6172_21640	COG1396	sequence-specific DNA binding
L6172_21645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L6172_21650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L6172_21655	COG1595	DNA-templated transcription, initiation
L6172_21675	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
L6172_21680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L6172_21700	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L6172_21715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L6172_21720	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L6172_21725	COG1185	polyribonucleotide nucleotidyltransferase activity
L6172_21740	COG1592	Rubrerythrin
L6172_21750	COG1120	ATPase activity
L6172_21755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6172_21800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L6172_21805	COG1268	BioY protein
L6172_21820	COG1305	Transglutaminase-like
L6172_21830	COG2308	Evidence 4 Homologs of previously reported genes of
L6172_21835	COG2875	Belongs to the precorrin methyltransferase family
L6172_21860	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
L6172_21865	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L6172_21880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6172_21890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L6172_21895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L6172_21940	COG1492	cobalamin metabolic process
L6172_21985	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
L6172_22000	COG1999	signal sequence binding
L6172_22005	COG1797	cobyrinic acid a,c-diamide synthase activity
L6172_22010	COG2983	Belongs to the UPF0260 family
L6172_22020	COG1234	tRNA 3'-trailer cleavage
L6172_22030	COG0071	Belongs to the small heat shock protein (HSP20) family
L6172_22040	COG0519	Catalyzes the synthesis of GMP from XMP
L6172_22055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6172_22090	COG0539	negative regulation of cytoplasmic translation
L6172_22095	COG0616	signal peptide processing
L6172_22100	COG0776	regulation of translation
L6172_22110	COG0284	orotidine-5'-phosphate decarboxylase activity
L6172_22115	COG2814	Major facilitator Superfamily
L6172_22120	COG0730	response to heat
L6172_22125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L6172_22130	COG1024	Enoyl-CoA hydratase
L6172_22135	COG0268	Binds directly to 16S ribosomal RNA