locus-tag	class	description
E2K93_00050	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
E2K93_00055	ENOG4105KHC	sulfurtransferase
E2K93_00060	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
E2K93_00065	ENOG4105WH1	Two component transcriptional regulator luxr family
E2K93_00075	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
E2K93_00090	ENOG4105C5H	ABC transporter
E2K93_00100	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
E2K93_00150	ENOG4105CIS	alcohol dehydrogenase
E2K93_00155	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
E2K93_00160	ENOG4105DR4	Methyltransferase
E2K93_00170	ENOG4105CQ7	ATP-dependent helicase
E2K93_00180	ENOG4105D44	asparaginase
E2K93_00190	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E2K93_00200	ENOG4107QYX	exodeoxyribonuclease v alpha
E2K93_00205	ENOG4107QKA	exodeoxyribonuclease V beta
E2K93_00210	ENOG4105DSY	exodeoxyribonuclease V, gamma
E2K93_00225	ENOG4105C4W	S-formylglutathione hydrolase
E2K93_00230	ENOG4107QPD	alcohol dehydrogenase
E2K93_00235	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
E2K93_00240	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
E2K93_00250	ENOG4105D2S	major facilitator superfamily
E2K93_00260	ENOG4105CJB	Exodeoxyribonuclease I
E2K93_00265	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
E2K93_00275	ENOG4105CFH	Aspartokinase
E2K93_00280	ENOG4107S90	membrAne
E2K93_00290	ENOG4105C9B	Cysteine desulfurase
E2K93_00305	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
E2K93_00310	ENOG4105C9B	Cysteine desulfurase
E2K93_00365	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
E2K93_00370	ENOG41064T2	transcriptional regulator, lysR family
E2K93_00375	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
E2K93_00380	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
E2K93_00385	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
E2K93_00390	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
E2K93_00395	ENOG4105CHV	Transcription elongation factor NusA
E2K93_00400	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
E2K93_00420	ENOG4105E0F	Histidine kinase
E2K93_00425	ENOG4107EXC	regulatoR
E2K93_00445	ENOG4107JPU	
E2K93_00460	ENOG4105C1J	atp-dependent rna helicase
E2K93_00475	ENOG4105E71	FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off
E2K93_00490	ENOG410679B	prophage CP4-57 regulatory protein alpA
E2K93_00500	ENOG4105DFP	Integrase
E2K93_00515	ENOG4105CP7	Triose-phosphate isomerase
E2K93_00520	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
E2K93_00525	ENOG4105EEI	dihydropteroate synthase
E2K93_00530	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
E2K93_00535	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
E2K93_00540	ENOG4105HBR	Rna-binding protein
E2K93_00545	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E2K93_00570	ENOG4105WH1	Two component transcriptional regulator luxr family
E2K93_00575	ENOG4105BZU	Histidine kinase
E2K93_00600	ENOG4105VEV	-acetyltransferase
E2K93_00605	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
E2K93_00610	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
E2K93_00615	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E2K93_00620	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
E2K93_00625	ENOG4108V1T	peptidylprolyl cis-trans isomerase
E2K93_00645	ENOG4105DS1	cytochrome b561
E2K93_00650	ENOG4107QNR	UPF0135 protein
E2K93_00660	ENOG4105D1A	Methyltransferase
E2K93_00665	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
E2K93_00670	ENOG4105E9H	Lytic Murein transglycosylase
E2K93_00675	ENOG4107S6Z	Na H antiporter
E2K93_00705	ENOG4105C8V	SAICAR synthetase
E2K93_00710	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
E2K93_00715	ENOG41082NX	50s ribosomal protein l35
E2K93_00725	ENOG4105C22	threonyL-tRNA synthetase
E2K93_00735	ENOG4105FGM	Fructosamine kinase
E2K93_00745	ENOG4108R6K	riboflavin synthase, subunit alpha
E2K93_00750	ENOG4107QI1	Mate efflux family protein
E2K93_00770	ENOG4105D5U	fad dependent oxidoreductase
E2K93_00805	ENOG41067XB	TonB family
E2K93_00810	ENOG4109015	Biopolymer transport protein exbD tolR
E2K93_00860	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
E2K93_00865	ENOG4108DNC	Involved in acetate metabolism (By similarity)
E2K93_00890	ENOG4105C7K	acetolactate synthase
E2K93_00900	ENOG4105K5B	UPF0225 protein
E2K93_00905	ENOG4105JJR	Histidine kinase
E2K93_00910	ENOG4107EXC	regulatoR
E2K93_00915	ENOG4105CGK	Exodeoxyribonuclease III
E2K93_00920	ENOG4105DHI	Methyltransferase
E2K93_00925	ENOG4105PQ6	UPF0208 membrane protein
E2K93_00935	ENOG4105KUZ	arsenate reductase
E2K93_00955	ENOG4105G2Y	Transcriptional regulator
E2K93_00965	ENOG4105CUZ	uba thif-type nad fad binding protein
E2K93_00980	ENOG4105DC7	peptidase M24
E2K93_00990	ENOG4107835	probably involved in intracellular septation (By similarity)
E2K93_00995	ENOG4105K9H	YciI-like protein
E2K93_01005	ENOG4105DSF	transport protein
E2K93_01010	ENOG4105ECP	epimerase
E2K93_01015	ENOG4105CV6	ABC transporter, permease
E2K93_01020	ENOG4108I0Y	(ABC) transporter
E2K93_01025	ENOG4108UJV	acyl-CoA thioesterase i
E2K93_01030	ENOG4105BZU	Histidine kinase
E2K93_01045	ENOG4105C8P	)-transporter
E2K93_01050	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
E2K93_01055	ENOG4105U5Y	Transcriptional regulator
E2K93_01075	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
E2K93_01085	ENOG4105C5X	domain protein
E2K93_01090	ENOG4105C8J	)-transporter
E2K93_01095	ENOG4107QSV	RmuC domain protein
E2K93_01100	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
E2K93_01110	ENOG4105CRQ	synthase (Component I)
E2K93_01120	ENOG4105EJQ	L-serine dehydratase
E2K93_01145	ENOG4106IUH	DTW domain containing protein
E2K93_01150	ENOG4108ZZ3	UPF0260 protein
E2K93_01155	ENOG4105CVE	Lytic murein transglycosylase
E2K93_01160	ENOG4105VNG	YcgL domain-containing protein
E2K93_01170	ENOG4105CEY	Amp-dependent synthetase and ligase
E2K93_01190	ENOG41072GX	Peptidase M22 Glycoprotease
E2K93_01195	ENOG4105DVT	helicase
E2K93_01200	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
E2K93_01205	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
E2K93_01210	ENOG4105CIH	Imidazole acetol-phosphate transaminase
E2K93_01215	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
E2K93_01225	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
E2K93_01230	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
E2K93_01235	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
E2K93_01240	ENOG4107YB6	acetyltransferase, (GNAT) family
E2K93_01260	ENOG41067XB	TonB family
E2K93_01275	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
E2K93_01280	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
E2K93_01285	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
E2K93_01305	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E2K93_01315	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
E2K93_01320	ENOG4107QMP	dna polymerase iii subunits gamma and tau
E2K93_01325	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
E2K93_01340	ENOG4108JJA	ABC, transporter
E2K93_01345	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
E2K93_01360	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
E2K93_01365	ENOG4105CY0	Metallo-Beta-Lactamase
E2K93_01375	ENOG4105Q9Y	Universal stress protein
E2K93_01390	ENOG4107QQG	Dehydrogenase
E2K93_01460	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
E2K93_01470	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
E2K93_01475	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
E2K93_01500	ENOG4105D3Q	Sugar transferase
E2K93_01520	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
E2K93_01580	ENOG4105D75	Capsular exopolysaccharide family
E2K93_01585	ENOG4105DAY	polysaccharide export protein
E2K93_01590	ENOG4105KJF	protein tyrosine phosphatase
E2K93_01630	ENOG4105D75	Capsular exopolysaccharide family
E2K93_01665	ENOG4105C9K	Endothelin-converting enzyme 1
E2K93_01670	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
E2K93_01680	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
E2K93_01685	ENOG4105C11	sulfate adenylyltransferase), subunit 2
E2K93_01690	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
E2K93_01695	ENOG4105W49	UPF0434 protein
E2K93_01700	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
E2K93_01705	ENOG4105BZ1	(ABC) transporter
E2K93_01710	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
E2K93_01725	ENOG4105D60	lipoprotein releasing system transmembrane protein
E2K93_01730	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E2K93_01735	ENOG4105D60	lipoprotein releasing system transmembrane protein
E2K93_01740	ENOG4108JA2	transcriptioN-repair coupling factor
E2K93_01755	ENOG4105CHJ	isochorismatase hydrolase
E2K93_01760	ENOG4105I08	Pseudouridine synthase
E2K93_01780	ENOG4108Z0R	Transferase
E2K93_01785	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E2K93_01790	ENOG41090ED	Protein with unknown function (DUF469)
E2K93_01795	ENOG4105CEN	a g-specific adenine glycosylase
E2K93_01800	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
E2K93_01825	ENOG4105EQJ	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity)
E2K93_01830	ENOG4105DH4	Periplasmic copper-binding protein
E2K93_01835	ENOG4105CIG	ABC transporter
E2K93_01840	ENOG4108T0W	nitrous oxide maturation protein NosY
E2K93_01860	ENOG4105BZU	Histidine kinase
E2K93_01870	ENOG4105VZ8	Transcriptional regulator
E2K93_01915	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
E2K93_01920	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
E2K93_01925	ENOG4105EWT	decarboxylase family
E2K93_01930	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
E2K93_01940	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E2K93_01945	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
E2K93_01950	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
E2K93_01965	ENOG4105ETT	transcriptional Regulator, LysR family
E2K93_01975	ENOG4107R11	Transcriptional regulator
E2K93_01980	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
E2K93_01990	ENOG4105CK2	sodium dicarboxylate symporter
E2K93_01995	ENOG4105FQ6	thiopurine methyltransferase
E2K93_02000	ENOG4105ERU	peptidase
E2K93_02010	ENOG4105UBK	short-chain dehydrogenase reductase
E2K93_02020	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
E2K93_02025	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
E2K93_02030	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
E2K93_02035	ENOG4108986	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
E2K93_02040	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
E2K93_02045	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E2K93_02050	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
E2K93_02055	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
E2K93_02060	ENOG4105C3G	gtp-binding protein
E2K93_02065	ENOG4108EKI	Dehydrogenase
E2K93_02075	ENOG4105VEQ	Cold shock protein
E2K93_02080	ENOG4108IQE	Amp-dependent synthetase and ligase
E2K93_02085	ENOG4105DR9	pseudouridine synthase
E2K93_02120	ENOG4105BZU	Histidine kinase
E2K93_02125	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
E2K93_02180	ENOG4105E2V	Glycosyltransferase 36
E2K93_02185	ENOG4105CT4	transporter
E2K93_02210	ENOG4105QV4	Tryptophan halogenase
E2K93_02245	ENOG4105CT4	transporter
E2K93_02250	ENOG41060NJ	transcriptional regulator
E2K93_02275	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E2K93_02280	ENOG4105C0A	alcohol dehydrogenase
E2K93_02285	ENOG4105C5F	glutamine synthetase
E2K93_02320	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
E2K93_02335	ENOG4105C5H	ABC transporter
E2K93_02345	ENOG4105HUJ	glyoxalase bleomycin resistance protein dioxygenase
E2K93_02355	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
E2K93_02360	ENOG4105C1J	atp-dependent rna helicase
E2K93_02370	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E2K93_02410	ENOG4108Z1Z	gCN5-related N-acetyltransferase
E2K93_02420	ENOG4105CEY	Amp-dependent synthetase and ligase
E2K93_02450	ENOG4105CQM	Urea amidohydrolase subunit alpha
E2K93_02455	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
E2K93_02485	ENOG4105DMF	Dehydrogenase
E2K93_02535	ENOG4105C19	ABC transporter
E2K93_02545	ENOG41075H3	AraC family transcriptional regulator
E2K93_02580	ENOG4105VG1	fes assembly suf system protein
E2K93_02590	ENOG4105HMI	Membrane
E2K93_02595	ENOG4105C1G	acyl-Coa dehydrogenase
E2K93_02605	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
E2K93_02610	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
E2K93_02615	ENOG4108DG9	Smr protein MutS2
E2K93_02620	ENOG4108BY2	phosphohistidine phosphatase
E2K93_02625	ENOG4107QXK	peptidase
E2K93_02630	ENOG4105BZU	Histidine kinase
E2K93_02640	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
E2K93_02645	ENOG4105CHU	acetyl-coa acetyltransferase
E2K93_02650	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
E2K93_02680	ENOG4105EMN	RNA polymerase sigma factor
E2K93_02690	ENOG4105CK7	Sodium proline symporter
E2K93_02695	ENOG4105D58	Diguanylate phosphodiesterase
E2K93_02700	ENOG4105CMR	udp-glucose 4-epimerase
E2K93_02735	ENOG4108IJ1	Dehydrogenase
E2K93_02740	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
E2K93_02745	ENOG4105ECX	polysaccharide export
E2K93_02755	ENOG41090SZ	ABC-2 type transporter
E2K93_02760	ENOG4107V1M	polysaccharide export protein
E2K93_02770	ENOG4105ESV	Glycosyl transferase, family 4
E2K93_02775	ENOG4105DUX	Transporter
E2K93_02780	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
E2K93_02790	ENOG4105CI2	imidazolone-5-propionate hydrolase
E2K93_02795	ENOG41063ZK	Transcriptional Regulator AraC Family
E2K93_02810	ENOG4105D05	Receptor
E2K93_02875	ENOG4108ZAI	phosphatidylglycerophosphatase a
E2K93_02880	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
E2K93_02885	ENOG4107YIM	Involved in the transcription termination process (By similarity)
E2K93_02890	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
E2K93_02900	ENOG410903C	(LipO)protein
E2K93_02905	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E2K93_02910	ENOG4105BZU	Histidine kinase
E2K93_02925	ENOG4105CV1	Transketolase (EC 2.2.1.1)
E2K93_02930	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E2K93_02935	ENOG4105BZA	Phosphoglycerate kinase
E2K93_02940	ENOG4105D2N	Aldolase
E2K93_02970	ENOG4105VDB	UPF0125 protein
E2K93_02975	ENOG4108Z1B	Cyclase dehydrase
E2K93_02980	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
E2K93_03015	ENOG4107EXC	regulatoR
E2K93_03075	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
E2K93_03080	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
E2K93_03085	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
E2K93_03090	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
E2K93_03095	ENOG4105DTN	riboflavin biosynthesis protein ribF
E2K93_03100	ENOG4105CJR	Integral membrane protein (MviN
E2K93_03105	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
E2K93_03120	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
E2K93_03125	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
E2K93_03130	ENOG4105HF0	Membrane
E2K93_03135	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
E2K93_03140	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
E2K93_03145	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
E2K93_03150	ENOG4105DSB	aldose 1-epimerase
E2K93_03270	ENOG4108KQJ	Type 11 methyltransferase
E2K93_03275	ENOG4105CKK	Glycosyl transferase, family 2
E2K93_03285	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E2K93_03290	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
E2K93_03295	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
E2K93_03300	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E2K93_03315	ENOG4105EMN	RNA polymerase sigma factor
E2K93_03320	ENOG4105C5Q	Transcriptional regulator
E2K93_03325	ENOG4105CJ3	phosphate transporter
E2K93_03330	ENOG4107IX6	phosphate transport regulator
E2K93_03340	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E2K93_03345	ENOG4105C8U	phosphate abc transporter
E2K93_03350	ENOG4105C8U	phosphate abc transporter
E2K93_03380	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
E2K93_03385	ENOG4105DGW	oligopeptidase A
E2K93_03390	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E2K93_03420	ENOG4105BZU	Histidine kinase
E2K93_03425	ENOG4105C5H	ABC transporter
E2K93_03430	ENOG4105C9K	Endothelin-converting enzyme 1
E2K93_03445	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
E2K93_03450	ENOG4105CFP	Peptidase U32
E2K93_03455	ENOG4105DH7	May be involved in recombination (By similarity)
E2K93_03460	ENOG41086DT	Membrane protein of unknown function
E2K93_03465	ENOG4105BZU	Histidine kinase
E2K93_03470	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E2K93_03500	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
E2K93_03505	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E2K93_03510	ENOG4105CTB	Polyprenyl synthetase
E2K93_03515	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
E2K93_03540	ENOG4105CFG	Acts as a chaperone (By similarity)
E2K93_03545	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
E2K93_03550	ENOG4105BZU	Histidine kinase
E2K93_03555	ENOG4105F27	Major Facilitator
E2K93_03565	ENOG4108VKG	metal-dependent hydrolase
E2K93_03575	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
E2K93_03605	ENOG4105CR8	Transcriptional regulator
E2K93_03615	ENOG4105JJR	Histidine kinase
E2K93_03620	ENOG4108KXV	response regulator
E2K93_03635	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
E2K93_03655	ENOG4105BZ1	(ABC) transporter
E2K93_03680	ENOG4107RZC	phospholipase d
E2K93_03690	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
E2K93_03695	ENOG41084CK	capsule polysaccharide
E2K93_03740	ENOG4107V1M	polysaccharide export protein
E2K93_03760	ENOG4105D6J	arsenicaL-resistance protein
E2K93_03765	ENOG4105C94	Transporter
E2K93_03775	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E2K93_03785	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
E2K93_03795	ENOG4108I6A	alcohol dehydrogenase
E2K93_03800	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
E2K93_03805	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
E2K93_03815	ENOG4105DKW	ABC transporter
E2K93_03820	ENOG4105DMF	Dehydrogenase
E2K93_03825	ENOG4105ERH	Fumarylacetoacetate hydrolase
E2K93_03835	ENOG4105EDR	glucose galactose transporter
E2K93_03855	ENOG4105CTX	dehydratase
E2K93_03885	ENOG41061MV	Arylsulfatase
E2K93_03890	ENOG4105ENH	Sulfatase
E2K93_03895	ENOG4105CBG	Sulfatase
E2K93_03900	ENOG4105CBG	Sulfatase
E2K93_03905	ENOG41061MV	Arylsulfatase
E2K93_03915	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2K93_03920	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
E2K93_03925	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
E2K93_03930	ENOG4105BZS	acriflavin resistance protein
E2K93_03940	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E2K93_03945	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
E2K93_03950	ENOG4105D0A	hydroxylase
E2K93_03955	ENOG4107RAQ	aminopeptidase
E2K93_03960	ENOG4105E07	UPF0149 protein
E2K93_03970	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
E2K93_03975	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
E2K93_03980	ENOG4105E66	phosphoriboisomerase A
E2K93_03985	ENOG4108JQ1	Dehydrogenase
E2K93_03990	ENOG4108MK9	spermidine N(1)-acetyltransferase
E2K93_04010	ENOG4105BZU	Histidine kinase
E2K93_04015	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
E2K93_04020	ENOG4105CRK	lysyL-tRNA synthetase
E2K93_04025	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
E2K93_04030	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
E2K93_04035	ENOG4105T95	Thiol disulfide interChange protein
E2K93_04040	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
E2K93_04045	ENOG4105C1J	atp-dependent rna helicase
E2K93_04065	ENOG4105D1Q	UPF0246 protein
E2K93_04070	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
E2K93_04080	ENOG4108UT2	hemolysin iii
E2K93_04085	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E2K93_04095	ENOG4105CJ1	ABC, transporter
E2K93_04100	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
E2K93_04120	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
E2K93_04140	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
E2K93_04150	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E2K93_04155	ENOG41085AN	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
E2K93_04160	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
E2K93_04165	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E2K93_04175	ENOG4108ZAF	Molybdopterin
E2K93_04185	ENOG4105E0C	molybdate abc transporter
E2K93_04190	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
E2K93_04195	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
E2K93_04200	ENOG4105VRT	cytoplasmic protein
E2K93_04205	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E2K93_04265	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
E2K93_04270	ENOG4105EB3	Histidine kinase
E2K93_04280	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
E2K93_04295	ENOG4105KKP	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase
E2K93_04300	ENOG410642E	Short chain dehydrogenase
E2K93_04305	ENOG4105EUJ	GTP cyclohydrolase i
E2K93_04320	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
E2K93_04335	ENOG4105EMU	Dehydrogenase
E2K93_04345	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
E2K93_04355	ENOG4108NIX	Factor ChrR
E2K93_04360	ENOG4105K6V	RNA polymerase
E2K93_04370	ENOG410906A	Beta-Ig-H3 fasciclin
E2K93_04375	ENOG4105QNF	Outer membrane lipoprotein
E2K93_04380	ENOG410624X	efflux transporter, rnd family, mfp subunit
E2K93_04385	ENOG4105BZS	acriflavin resistance protein
E2K93_04420	ENOG4105CIY	formyltetrahydrofolate deformylase
E2K93_04440	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E2K93_04445	ENOG4105D2N	Aldolase
E2K93_04450	ENOG4108UHU	Aldolase
E2K93_04455	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
E2K93_04460	ENOG4105DPW	Major facilitator superfamily MFS_1
E2K93_04470	ENOG4105EY3	heparinase II III family protein
E2K93_04480	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
E2K93_04495	ENOG4107YCY	Transcriptional regulator
E2K93_04515	ENOG4105C0A	alcohol dehydrogenase
E2K93_04520	ENOG4108RCM	Nitroreductase
E2K93_04535	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
E2K93_04540	ENOG4105D1S	lipid A biosynthesis
E2K93_04560	ENOG4108JPV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
E2K93_04600	ENOG4106MWK	domain protein
E2K93_04610	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
E2K93_04625	ENOG4107RZX	Teichoic acid biosynthesis protein
E2K93_04630	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
E2K93_04635	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E2K93_04640	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E2K93_04645	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E2K93_04660	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
E2K93_04665	ENOG4105K4P	CoA-binding domain protein
E2K93_04670	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
E2K93_04675	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E2K93_04680	ENOG4107ZVW	dihydroneopterin aldolase
E2K93_04685	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
E2K93_04690	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E2K93_04695	ENOG4105VCC	30S ribosomal protein S21
E2K93_04700	ENOG4105KTH	gatB Yqey
E2K93_04705	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
E2K93_04710	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E2K93_04725	ENOG4105BZU	Histidine kinase
E2K93_04735	ENOG4105DFP	Integrase
E2K93_04775	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
E2K93_04810	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
E2K93_04830	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
E2K93_04845	ENOG4106428	Protein of unknown function (DUF2496)
E2K93_04850	ENOG4105E4C	Lytic transglycosylase catalytic
E2K93_04870	ENOG4105C8J	)-transporter
E2K93_04875	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
E2K93_04880	ENOG4108NIW	Leucine export protein LeuE
E2K93_04905	ENOG41082IR	Excinuclease ABC C subunit domain protein
E2K93_04910	ENOG4108YZN	class I peptide chain release factor
E2K93_04920	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E2K93_04975	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
E2K93_04985	ENOG4105CXK	mandelate racemase muconate lactonizing
E2K93_04990	ENOG4105MP9	class II Aldolase
E2K93_04995	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
E2K93_05005	ENOG4105EW9	transcriptional regulator AsnC family
E2K93_05020	ENOG4108DQR	cina-like protein
E2K93_05040	ENOG4105C5I	Dehydrogenase
E2K93_05055	ENOG4105F4E	fad dependent oxidoreductase
E2K93_05065	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
E2K93_05070	ENOG4105D98	threonine synthase
E2K93_05075	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
E2K93_05090	ENOG4105X2V	dna damage-inducible protein
E2K93_05110	ENOG4105CH2	amidohydrolase
E2K93_05125	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
E2K93_05125	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
E2K93_05140	ENOG4108R4R	Iron-regulated virulence regulatory protein
E2K93_05145	ENOG4105C26	Dehydrogenase
E2K93_05165	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
E2K93_05170	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
E2K93_05175	ENOG4105DFU	Cell wall formation (By similarity)
E2K93_05185	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E2K93_05210	ENOG4107QY8	reductase
E2K93_05215	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
E2K93_05245	ENOG4105CHU	acetyl-coa acetyltransferase
E2K93_05250	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
E2K93_05255	ENOG4105F0N	pyrophosphate phospho-hydrolase
E2K93_05260	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E2K93_05265	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
E2K93_05275	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
E2K93_05305	ENOG41087YS	Phage shock protein A
E2K93_05315	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
E2K93_05325	ENOG4105MYN	Zinc uptake regulation protein
E2K93_05335	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E2K93_05340	ENOG4105CDU	Replicative dna helicase
E2K93_05345	ENOG4105ED1	spovr family
E2K93_05350	ENOG4106AKX	UPF0229 protein
E2K93_05355	ENOG4105CYN	Serine protein kinase
E2K93_05375	ENOG4105E7W	lamb ycsf family protein
E2K93_05385	ENOG4107R7A	Allophanate hydrolase subunit 2
E2K93_05390	ENOG4105WD1	Membrane
E2K93_05395	ENOG4108W15	Protein of unknown function (DUF1456)
E2K93_05405	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
E2K93_05410	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
E2K93_05420	ENOG4105C25	Primosomal protein n'
E2K93_05425	ENOG4105VFB	Binds the 23S rRNA (By similarity)
E2K93_05445	ENOG4105DGW	oligopeptidase A
E2K93_05460	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
E2K93_05465	ENOG4105CI2	imidazolone-5-propionate hydrolase
E2K93_05485	ENOG4105CGP	Urocanate hydratase
E2K93_05490	ENOG4105C84	Histidine ammonia-lyase
E2K93_05495	ENOG4105CZE	histidine utilization repressor
E2K93_05505	ENOG4105CHF	Glutathione S-transferase
E2K93_05515	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
E2K93_05560	ENOG4108535	NAD dependent epimerase/dehydratase family
E2K93_05565	ENOG4105SUU	thioesterase domain
E2K93_05570	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
E2K93_05580	ENOG4107S2Z	UPF0761 membrane protein
E2K93_05595	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
E2K93_05615	ENOG4105C5F	glutamine synthetase
E2K93_05625	ENOG4105CUX	Signal transduction histidine kinase
E2K93_05630	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E2K93_05640	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
E2K93_05645	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E2K93_05650	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
E2K93_05675	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
E2K93_05680	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
E2K93_05690	ENOG4105VF7	tolerance protein
E2K93_05695	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
E2K93_05700	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
E2K93_05705	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
E2K93_05710	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
E2K93_05735	ENOG4105C2C	drug resistance transporter, Bcr CflA
E2K93_05740	ENOG4105QVC	MOSC domain-containing protein
E2K93_05745	ENOG4105DDQ	anthranilate synthase
E2K93_05765	ENOG4105C26	Dehydrogenase
E2K93_05780	ENOG4108UKZ	OsmC family
E2K93_05790	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
E2K93_05795	ENOG4108ZT0	50S ribosomal protein l17
E2K93_05800	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E2K93_05805	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
E2K93_05810	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
E2K93_05815	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E2K93_05820	ENOG41067V7	50S ribosomal protein L36
E2K93_05825	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
E2K93_05830	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
E2K93_05835	ENOG4105VPB	50S ribosomal protein L30
E2K93_05840	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
E2K93_05845	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
E2K93_05850	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
E2K93_05855	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
E2K93_05860	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E2K93_05865	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E2K93_05870	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
E2K93_05875	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
E2K93_05880	ENOG4105BZU	Histidine kinase
E2K93_05890	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
E2K93_05895	ENOG41083MP	50s ribosomal protein l29
E2K93_05900	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
E2K93_05905	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
E2K93_05910	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
E2K93_05915	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
E2K93_05920	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E2K93_05925	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
E2K93_05930	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
E2K93_05935	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
E2K93_05940	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
E2K93_05945	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
E2K93_05960	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E2K93_05965	ENOG4105DWD	nucleoside recognition domain protein
E2K93_05970	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
E2K93_05975	ENOG4105EJ2	Transcriptional regulator
E2K93_05995	ENOG4105D64	Mechanosensitive ion channel
E2K93_06030	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E2K93_06035	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
E2K93_06045	ENOG4105GAV	receptor
E2K93_06050	ENOG41080HT	Transcriptional regulator, arsr family
E2K93_06055	ENOG4105BZS	acriflavin resistance protein
E2K93_06085	ENOG4108QDA	dioxygenase
E2K93_06095	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E2K93_06100	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
E2K93_06105	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
E2K93_06110	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
E2K93_06115	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E2K93_06120	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E2K93_06125	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
E2K93_06130	ENOG4108VZM	50s ribosomal protein L10
E2K93_06135	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
E2K93_06140	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
E2K93_06150	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
E2K93_06155	ENOG4105PM1	preprotein translocase subunit SecE
E2K93_06180	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E2K93_06205	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
E2K93_06210	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
E2K93_06215	ENOG4105D4A	Cell wall formation (By similarity)
E2K93_06220	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
E2K93_06230	ENOG4105PBF	Anti-RNA polymerase sigma 70 factor
E2K93_06235	ENOG4108V1T	peptidylprolyl cis-trans isomerase
E2K93_06240	ENOG41069P5	Protein slyX homolog
E2K93_06245	ENOG4105VKU	nucleicacid-binding protein
E2K93_06250	ENOG4105C5H	ABC transporter
E2K93_06255	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
E2K93_06265	ENOG4105DNZ	Alpha Beta Hydrolase
E2K93_06270	ENOG4105YP7	UPF0270 protein
E2K93_06280	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
E2K93_06285	ENOG4107RK2	ADP-ribose diphosphatase NudE
E2K93_06290	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
E2K93_06295	ENOG4105CIN	aminoacyl-histidine dipeptidase
E2K93_06300	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
E2K93_06305	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
E2K93_06310	ENOG4105W5Q	DNA repair protein (RadC
E2K93_06315	ENOG4105CGZ	zinc metallopeptidase
E2K93_06320	ENOG4105KDC	50s ribosomal protein l28
E2K93_06325	ENOG4105W0E	50S ribosomal protein L33
E2K93_06330	ENOG4108V0P	LemA family
E2K93_06335	ENOG4105D0M	Protease HtpX homolog
E2K93_06340	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
E2K93_06345	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
E2K93_06350	ENOG4107Z3H	Transcriptional regulator, TetR family
E2K93_06355	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
E2K93_06360	ENOG4105DKP	glycosyl transferase, family 9
E2K93_06380	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
E2K93_06385	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E2K93_06390	ENOG4105CPQ	Dehydrogenase
E2K93_06395	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
E2K93_06405	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
E2K93_06420	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
E2K93_06430	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E2K93_06435	ENOG4108VUY	thioesterase Superfamily protein
E2K93_06440	ENOG4105FR1	rard protein
E2K93_06460	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
E2K93_06485	ENOG4105CVK	Glutamate decarboxylase
E2K93_06490	ENOG4105DJB	Major Facilitator Superfamily
E2K93_06510	ENOG4108M3P	Membrane
E2K93_06515	ENOG4105C4R	Atp-dependent dna helicase
E2K93_06525	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
E2K93_06535	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
E2K93_06540	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
E2K93_06550	ENOG4105XQ6	frataxin-like protein
E2K93_06555	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
E2K93_06565	ENOG4105ECF	c-methyltransferase
E2K93_06590	ENOG4105C5Q	Transcriptional regulator
E2K93_06620	ENOG4105MKQ	Monovalent cation H antiporter subunit C
E2K93_06625	ENOG4108JPZ	Monovalent cation H antiporter subunit D
E2K93_06630	ENOG4108JPZ	Monovalent cation H antiporter subunit D
E2K93_06640	ENOG4105D65	subunit l
E2K93_06660	ENOG4105E55	glycerol-3-phosphate acyltransferase
E2K93_06675	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
E2K93_06680	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
E2K93_06690	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
E2K93_06695	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
E2K93_06715	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
E2K93_06720	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
E2K93_06730	ENOG4105CDY	transcriptional regulatory protein
E2K93_06735	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
E2K93_06740	ENOG4105IU3	Glutathione S-transferase
E2K93_06745	ENOG4107BJW	polysaccharide deacetylase
E2K93_06750	ENOG4107R73	Mate efflux family protein
E2K93_06755	ENOG4105DXI	Major Facilitator superfamily
E2K93_06760	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
E2K93_06770	ENOG4105MJ2	Competence protein
E2K93_06775	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
E2K93_06785	ENOG4105D64	Mechanosensitive ion channel
E2K93_06800	ENOG4105G2Y	Transcriptional regulator
E2K93_06810	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
E2K93_06815	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
E2K93_06835	ENOG4105DSJ	YicC domain protein
E2K93_06845	ENOG4108YXG	UPF0502 protein
E2K93_06855	ENOG4108PTX	LysR family Transcriptional regulator
E2K93_06865	ENOG4108MCI	Transcriptional regulator, ARAC family
E2K93_06870	ENOG41067MG	lrgb family
E2K93_06915	ENOG4108UQY	Iron-storage protein
E2K93_06930	ENOG4105CGF	Aromatic amino acid aminotransferase
E2K93_06935	ENOG4105CM2	brancheD-chain amino acid aminotransferase
E2K93_06945	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
E2K93_06950	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
E2K93_06955	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E2K93_06960	ENOG4105KME	endoribonuclease L-psp
E2K93_06965	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
E2K93_06970	ENOG4105CB5	ATP-dependent DNA helicase recG
E2K93_06975	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
E2K93_06980	ENOG4105JC1	sterol-binding domain protein
E2K93_06985	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
E2K93_06995	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
E2K93_07005	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
E2K93_07020	ENOG4105D52	delta-aminolevulinic acid dehydratase
E2K93_07030	ENOG4105C9X	ppx gppa phosphatase
E2K93_07040	ENOG4105K63	Thioredoxin
E2K93_07050	ENOG4105FE9	pseudouridine synthase
E2K93_07055	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
E2K93_07060	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
E2K93_07070	ENOG4107YZP	Rhodanese domain protein
E2K93_07075	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E2K93_07080	ENOG41063SB	peptidase
E2K93_07090	ENOG4105PXI	polysaccharide deacetylase
E2K93_07095	ENOG4105C0H	protease
E2K93_07155	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
E2K93_07180	ENOG4105D7W	serine acetyltransferase
E2K93_07185	ENOG4105CPK	Glycosyl transferase (Group 1
E2K93_07210	ENOG4108QV3	biosynthesis protein
E2K93_07225	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E2K93_07230	ENOG4105BZU	Histidine kinase
E2K93_07245	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
E2K93_07260	ENOG4105CHR	reductase
E2K93_07265	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
E2K93_07270	ENOG4105ETE	Transcriptional regulator (LacI family
E2K93_07280	ENOG4105CNV	Aldolase
E2K93_07300	ENOG4107RJ1	sodium solute
E2K93_07330	ENOG4107RDJ	Sulfotransferase
E2K93_07335	ENOG4105CNM	Receptor
E2K93_07360	ENOG4105CBG	Sulfatase
E2K93_07370	ENOG4105DRR	Transcriptional regulator, GntR family
E2K93_07380	ENOG4107YRA	Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity)
E2K93_07385	ENOG4105CXK	mandelate racemase muconate lactonizing
E2K93_07390	ENOG4105C26	Dehydrogenase
E2K93_07410	ENOG4105EPW	hflc protein
E2K93_07425	ENOG41061MV	Arylsulfatase
E2K93_07430	ENOG4105ENH	Sulfatase
E2K93_07435	ENOG4105EI3	2-dehydro-3-deoxygalactonokinase EC 2.7.1.58
E2K93_07445	ENOG4108ZKT	aldose 1-epimerase
E2K93_07460	ENOG4108RTU	Aldolase
E2K93_07465	ENOG4105EI3	2-dehydro-3-deoxygalactonokinase EC 2.7.1.58
E2K93_07470	ENOG4105FGE	Short-chain dehydrogenase reductase Sdr
E2K93_07475	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
E2K93_07490	ENOG4105CNT	hydrolase family 2
E2K93_07500	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
E2K93_07525	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
E2K93_07530	ENOG41061MV	Arylsulfatase
E2K93_07535	ENOG4105ENH	Sulfatase
E2K93_07560	ENOG4105CNT	hydrolase family 2
E2K93_07570	ENOG4105CBG	Sulfatase
E2K93_07595	ENOG4105CBG	Sulfatase
E2K93_07600	ENOG4105CBG	Sulfatase
E2K93_07605	ENOG4105CNT	hydrolase family 2
E2K93_07610	ENOG41061MV	Arylsulfatase
E2K93_07620	ENOG41061MV	Arylsulfatase
E2K93_07625	ENOG4105CNT	hydrolase family 2
E2K93_07635	ENOG4107EJG	GntR family transcriptional regulator
E2K93_07640	ENOG4105CMR	udp-glucose 4-epimerase
E2K93_07645	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
E2K93_07650	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
E2K93_07670	ENOG4108Z33	Thiol disulfide Interchange Protein
E2K93_07705	ENOG410804X	Transcriptional regulator
E2K93_07710	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
E2K93_07720	ENOG4105CYM	Glutathione S-transferase
E2K93_07725	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
E2K93_07730	ENOG4105D9R	oxidoreductase
E2K93_07740	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E2K93_07750	ENOG41082YX	Transcriptional regulator, arsr family
E2K93_07755	ENOG4105EHV	domain protein
E2K93_07760	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
E2K93_07780	ENOG4105EMK	carboxylate amino acid amine transporter
E2K93_07785	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
E2K93_07795	ENOG4105R2J	Conserved Protein
E2K93_07800	ENOG4105WKW	Pfam:DUF1458
E2K93_07805	ENOG4106H78	methyltransferase
E2K93_07810	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
E2K93_07815	ENOG4105CAK	Cell division ATP-binding protein ftsE
E2K93_07820	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
E2K93_07825	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E2K93_07830	ENOG4105BZU	Histidine kinase
E2K93_07840	ENOG4105C4R	Atp-dependent dna helicase
E2K93_07845	ENOG4105W0Z	cytoplasmic protein
E2K93_07850	ENOG4105C7B	Threonine dehydratase
E2K93_07855	ENOG4105C01	Dihydroxy-acid dehydratase
E2K93_07860	ENOG4105CM2	brancheD-chain amino acid aminotransferase
E2K93_07870	ENOG4105C0P	Mg chelatase subunit ChlI
E2K93_07875	ENOG4105EMY	transcriptional regulator
E2K93_07880	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
E2K93_07885	ENOG4105HDK	L-asparaginase
E2K93_07890	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
E2K93_07895	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
E2K93_07900	ENOG4105CUY	Mechanosensitive ion channel
E2K93_07905	ENOG4105C29	acyl-CoA thioesterase
E2K93_07930	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
E2K93_07935	ENOG4105KG3	cytidine deaminase
E2K93_07945	ENOG4105IH7	synthase
E2K93_07980	ENOG4105QV4	Tryptophan halogenase
E2K93_07990	ENOG4107RGM	aldo keto reductase
E2K93_08005	ENOG4105VZ8	Transcriptional regulator
E2K93_08025	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
E2K93_08035	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
E2K93_08040	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
E2K93_08055	ENOG4107QN1	sodium solute
E2K93_08100	ENOG41068WN	
E2K93_08105	ENOG41082W1	Cupin 2, conserved barrel domain protein
E2K93_08140	ENOG4108XC3	NADH ubiquinone oxidoreductase
E2K93_08145	ENOG4108S58	Phenazine biosynthesis protein PhzF
E2K93_08185	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E2K93_08190	ENOG4105CTM	Glycoside hydrolase family 5
E2K93_08215	ENOG4107R6D	beta-lactam binding protein AmpH
E2K93_08295	ENOG4108UPT	UPF0178 protein
E2K93_08300	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
E2K93_08315	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
E2K93_08325	ENOG4108NST	exported protein
E2K93_08340	ENOG4107Z7P	Ferredoxin
E2K93_08350	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
E2K93_08360	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
E2K93_08365	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E2K93_08370	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E2K93_08375	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E2K93_08380	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
E2K93_08385	ENOG41064MJ	ATP synthase, subunit I
E2K93_08390	ENOG4105FA0	parb-like partition protein
E2K93_08395	ENOG4107QJE	Chromosome Partitioning Protein
E2K93_08400	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
E2K93_08405	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
E2K93_08410	ENOG4105QTB	Flavodoxin
E2K93_08415	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
E2K93_08420	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
E2K93_08425	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
E2K93_08430	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
E2K93_08435	ENOG4105VG0	50S ribosomal protein l34
E2K93_08440	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
E2K93_08445	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
E2K93_08450	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E2K93_08455	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E2K93_08460	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
E2K93_08465	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
E2K93_08470	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
E2K93_08475	ENOG4107SC1	transglycosylase
E2K93_08480	ENOG4105D9Y	Splits dipeptides with a prolyl residue in the C- terminal position (By similarity)
E2K93_08485	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
E2K93_08490	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
E2K93_08495	ENOG4105C1A	potassium transporter peripheral membrane
E2K93_08500	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E2K93_08505	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
E2K93_08510	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E2K93_08520	ENOG4105C79	DNA protecting protein DprA
E2K93_08525	ENOG4108RPN	Protein smg homolog
E2K93_08535	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
E2K93_08540	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
E2K93_08545	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E2K93_08550	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
E2K93_08560	ENOG4105E68	Sulfatase
E2K93_08565	ENOG4105EIF	outer membrane protein W
E2K93_08570	ENOG4105E2X	shikimate dehydrogenase
E2K93_08580	ENOG4108Z0R	Transferase
E2K93_08625	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
E2K93_08640	ENOG4105D4P	Coproporphyrinogen iii oxidase
E2K93_08660	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
E2K93_08675	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
E2K93_08690	ENOG4106RE7	Cytochrome
E2K93_08695	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
E2K93_08705	ENOG4105C2M	dna polymerase I
E2K93_08710	ENOG4105DC8	reductase
E2K93_08715	ENOG4105DGW	oligopeptidase A
E2K93_08725	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
E2K93_08735	ENOG4105D3R	alkyl hydroperoxide reductase
E2K93_08740	ENOG4105C5Q	Transcriptional regulator
E2K93_08755	ENOG41090A1	ferritin
E2K93_08760	ENOG4105CBX	hi0933 family
E2K93_08800	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
E2K93_08820	ENOG4105DWF	phosphomethylpyrimidine kinase
E2K93_08825	ENOG4105D06	uba thif-type nad fad binding protein
E2K93_08840	ENOG41062A4	Transcriptional regulator
E2K93_08850	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
E2K93_08885	ENOG4105CK7	Sodium proline symporter
E2K93_08890	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
E2K93_08915	ENOG4105C1G	acyl-Coa dehydrogenase
E2K93_08920	ENOG4108UAU	isochorismatase
E2K93_08950	ENOG4107QZF	nitrite reductase NADPH large subunit
E2K93_08970	ENOG4105CHR	reductase
E2K93_08975	ENOG4105D94	Major Facilitator Superfamily
E2K93_08995	ENOG4105C1G	acyl-Coa dehydrogenase
E2K93_09005	ENOG4105C26	Dehydrogenase
E2K93_09015	ENOG4108UAU	isochorismatase
E2K93_09025	ENOG4108ESX	Receptor
E2K93_09050	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
E2K93_09060	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E2K93_09065	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E2K93_09095	ENOG4105DTD	Dehydrogenase
E2K93_09110	ENOG41079KZ	Major Facilitator Superfamily
E2K93_09120	ENOG4105DTD	Dehydrogenase
E2K93_09130	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
E2K93_09150	ENOG4105FDP	GntR family transcriptional regulator
E2K93_09170	ENOG4107RDJ	Sulfotransferase
E2K93_09175	ENOG4105D05	Receptor
E2K93_09185	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
E2K93_09190	ENOG4108JPW	Aminotransferase
E2K93_09200	ENOG4105EVZ	LysR family transcriptional regulator
E2K93_09210	ENOG4105VP2	Transcriptional regulator, Crp Fnr family
E2K93_09235	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
E2K93_09240	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
E2K93_09250	ENOG4105DDY	UPF0142 protein ycaO
E2K93_09275	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E2K93_09280	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
E2K93_09300	ENOG4105C26	Dehydrogenase
E2K93_09350	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
E2K93_09360	ENOG4105CI0	Citrate lyase
E2K93_09370	ENOG4105C1G	acyl-Coa dehydrogenase
E2K93_09380	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
E2K93_09405	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
E2K93_09410	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
E2K93_09430	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
E2K93_09440	ENOG4105DJG	MaoC domain protein dehydratase
E2K93_09445	ENOG4105CI0	Citrate lyase
E2K93_09475	ENOG4105CNG	UPF0061 protein
E2K93_09480	ENOG4105N7H	Cytochrome
E2K93_09505	ENOG4107QK7	reductase
E2K93_09510	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
E2K93_09520	ENOG4105CD3	dihydroorotase
E2K93_09525	ENOG4105CI2	imidazolone-5-propionate hydrolase
E2K93_09530	ENOG4108MAJ	Membrane
E2K93_09535	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
E2K93_09540	ENOG41076HS	cation diffusion facilitator family transporter
E2K93_09545	ENOG4108EUD	Lysophospholipase
E2K93_09550	ENOG4105E0F	Histidine kinase
E2K93_09555	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
E2K93_09585	ENOG4105BZW	Glycerate kinase
E2K93_09590	ENOG4105BZM	domain protein
E2K93_09595	ENOG4108RRZ	Transcription elongation factor GreB
E2K93_09600	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
E2K93_09605	ENOG4105E0F	Histidine kinase
E2K93_09615	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
E2K93_09620	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
E2K93_09625	ENOG4105VEJ	Heat shock protein
E2K93_09640	ENOG4107QHF	type ii secretion system protein e
E2K93_09645	ENOG4105D7Q	type ii secretion system
E2K93_09650	ENOG4108VAU	general secretion pathway protein G
E2K93_09690	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
E2K93_09695	ENOG4105DJ4	phosphatidylserine decarboxylase
E2K93_09700	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
E2K93_09705	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
E2K93_09725	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
E2K93_09730	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
E2K93_09735	ENOG4105K8N	protein family UPF0079, ATPase
E2K93_09740	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
E2K93_09745	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
E2K93_09750	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
E2K93_09755	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
E2K93_09760	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
E2K93_09765	ENOG4107QJR	hflk protein
E2K93_09770	ENOG4105EPW	hflc protein
E2K93_09780	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
E2K93_09800	ENOG4105C6K	Malic enzyme
E2K93_09805	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
E2K93_09810	ENOG4105C28	cystathionine
E2K93_09815	ENOG4105CFH	Aspartokinase
E2K93_09820	ENOG4105SYT	Methylenetetrahydrofolate reductase
E2K93_09830	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
E2K93_09835	ENOG4105CAS	nag kinase
E2K93_09840	ENOG4105DBV	ornithine carbamoyltransferase
E2K93_09845	ENOG4105CDH	Citrulline--aspartate ligase
E2K93_09855	ENOG4108JQC	penicillin-binding protein 1A
E2K93_09880	ENOG4105E4G	Type IV pilus
E2K93_09885	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
E2K93_09890	ENOG4105D49	3-dehydroquinate synthase
E2K93_09895	ENOG4105DFE	Dna adenine methylase
E2K93_09910	ENOG4105DJV	ribulose-phosphate 3-epimerase
E2K93_09915	ENOG4105C31	Tryptophanyl-tRNA synthetase
E2K93_09925	ENOG4105C0H	protease
E2K93_09945	ENOG4107TII	Recombinase
E2K93_09995	ENOG4105DS1	cytochrome b561
E2K93_10000	ENOG4105EAU	Plays a role in nitrite reduction (By similarity)
E2K93_10005	ENOG4107R11	Transcriptional regulator
E2K93_10020	ENOG4105CFC	Transporter
E2K93_10030	ENOG4105ERG	peptidase m48, ste24p
E2K93_10045	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
E2K93_10050	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E2K93_10055	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
E2K93_10060	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
E2K93_10065	ENOG4105DC1	bifunctional purine biosynthesis protein purh
E2K93_10075	ENOG4105C12	Phosphoribosylglycinamide synthetase
E2K93_10140	ENOG4105JIM	Phosphatidylserine synthase
E2K93_10155	ENOG4107RDB	Major Facilitator
E2K93_10165	ENOG4105DA5	(ABC) transporter
E2K93_10170	ENOG4105E3A	(ABC) transporter
E2K93_10175	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E2K93_10180	ENOG4105CPK	Glycosyl transferase (Group 1
E2K93_10190	ENOG4105DY8	decarboxylase
E2K93_10195	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
E2K93_10200	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
E2K93_10205	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E2K93_10210	ENOG4105DJ0	Poly(A) Polymerase
E2K93_10215	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
E2K93_10220	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E2K93_10225	ENOG4105PW4	Sugar fermentation stimulation protein homolog
E2K93_10235	ENOG4105D64	Mechanosensitive ion channel
E2K93_10250	ENOG4105CQ7	ATP-dependent helicase
E2K93_10255	ENOG4105BZ4	penicillin-binding protein
E2K93_10260	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
E2K93_10265	ENOG4105CXT	aspartate transcarbamylase
E2K93_10270	ENOG4108YXA	Membrane
E2K93_10285	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
E2K93_10320	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
E2K93_10325	ENOG4105C2N	RNA methyltransferase TrmH family group 3
E2K93_10330	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
E2K93_10335	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
E2K93_10340	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
E2K93_10345	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
E2K93_10365	ENOG4105DFF	Rod shape-determining protein mreb
E2K93_10370	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
E2K93_10375	ENOG4105VQ7	Rod shape-determining protein MreD
E2K93_10380	ENOG4108Z03	MAF-like protein
E2K93_10385	ENOG4105C03	ribonuclease
E2K93_10400	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
E2K93_10405	ENOG4105N42	UPF0307 protein
E2K93_10410	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
E2K93_10415	ENOG4105CJW	magnesium transporter
E2K93_10420	ENOG41080Z8	PHOSPHOCARRIER protein
E2K93_10425	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
E2K93_10430	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
E2K93_10435	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
E2K93_10440	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E2K93_10445	ENOG4108IUZ	ABC transporter
E2K93_10460	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
E2K93_10465	ENOG4105C2X	Arabinose 5-phosphate isomerase
E2K93_10475	ENOG4108NFH	Sugar hydrolase
E2K93_10480	ENOG4108NFH	Sugar hydrolase
E2K93_10485	ENOG4105DHJ	ABC, transporter
E2K93_10490	ENOG4105CY3	ABC transporter, permease
E2K93_10495	ENOG4107PE3	Mammalian cell entry related domain protein
E2K93_10500	ENOG4105E3I	toluene tolerance
E2K93_10510	ENOG4105VFK	BolA family
E2K93_10515	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E2K93_10520	ENOG4105C0H	protease
E2K93_10525	ENOG4105C0H	protease
E2K93_10535	ENOG4105D6Z	AFG1 family ATPase
E2K93_10540	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
E2K93_10545	ENOG4108UJD	30S ribosomal protein S9
E2K93_10550	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
E2K93_10555	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
E2K93_10560	ENOG4105EIX	cytochrome c1
E2K93_10565	ENOG4107MKT	Stringent starvation protein a
E2K93_10570	ENOG4105KB2	stringent starvation protein b
E2K93_10585	ENOG4105W4M	Transport-associated protein
E2K93_10590	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
E2K93_10595	ENOG41082RQ	UPF0102 protein
E2K93_10605	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
E2K93_10625	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
E2K93_10640	ENOG4105CY2	Citrate transporter
E2K93_10650	ENOG4108NE3	Salt-induced outer membrane protein
E2K93_10655	ENOG4105BZU	Histidine kinase
E2K93_10660	ENOG4107QP8	phosphohexose isomerase
E2K93_10665	ENOG4105CV1	Transketolase (EC 2.2.1.1)
E2K93_10670	ENOG4108V6E	Cell division protein mraZ
E2K93_10675	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
E2K93_10685	ENOG4105CJN	penicillin-binding protein
E2K93_10690	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
E2K93_10695	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
E2K93_10700	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
E2K93_10705	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
E2K93_10710	ENOG4105CNI	cell division protein FtsW
E2K93_10715	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E2K93_10720	ENOG4105DFU	Cell wall formation (By similarity)
E2K93_10725	ENOG4105CPF	Cell wall formation (By similarity)
E2K93_10730	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
E2K93_10735	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
E2K93_10740	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
E2K93_10745	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E2K93_10755	ENOG4105DR5	peptidase
E2K93_10760	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
E2K93_10775	ENOG4105W8I	Transcriptional regulator
E2K93_10785	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
E2K93_10790	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
E2K93_10795	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
E2K93_10805	ENOG4105D7Q	type ii secretion system
E2K93_10810	ENOG4107QHF	type ii secretion system protein e
E2K93_10820	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
E2K93_10840	ENOG41073TP	transcriptional regulator
E2K93_10845	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
E2K93_10850	ENOG4107QSN	dihydrolipoamide acetyltransferase
E2K93_10855	ENOG4107QN2	dihydrolipoyl dehydrogenase
E2K93_10865	ENOG4105Y49	secretion protein, HlyD family
E2K93_10885	ENOG4107QIJ	Aconitate hydratase 2
E2K93_10900	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
E2K93_10915	ENOG4108YZA	Nitrogen regulatory protein pii
E2K93_10935	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
E2K93_10940	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
E2K93_10945	ENOG4105EZR	dyp-type peroxidase family protein
E2K93_10950	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
E2K93_10955	ENOG4105NWN	ApaG protein
E2K93_10960	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
E2K93_10965	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
E2K93_10970	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
E2K93_10975	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
E2K93_10980	ENOG4105EHM	Aminoglycoside phosphotransferase
E2K93_10985	ENOG4108S0S	Nucleotidyl transferase
E2K93_10990	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
E2K93_10995	ENOG4105D3G	Pseudouridine synthase
E2K93_11000	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
E2K93_11005	ENOG4108IAB	Phoh family
E2K93_11015	ENOG4105H3G	oxidoreductase
E2K93_11020	ENOG4105CSU	acyl-Coa dehydrogenase
E2K93_11025	ENOG4107EXC	regulatoR
E2K93_11030	ENOG4109015	Biopolymer transport protein exbD tolR
E2K93_11045	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
E2K93_11050	ENOG4105X3C	heme exporter protein
E2K93_11055	ENOG41060IM	Heme exporter protein
E2K93_11060	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
E2K93_11065	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
E2K93_11070	ENOG4105DA4	cytochrome c-type biogenesis protein
E2K93_11075	ENOG4107QX9	Thiol disulfide interChange protein
E2K93_11080	ENOG4105KWW	Biogenesis protein
E2K93_11085	ENOG4108M1T	Cytochrome c-type biogenesis protein
E2K93_11095	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
E2K93_11100	ENOG4105CHH	sulfate transporter
E2K93_11105	ENOG4105XZD	Fe-S protein
E2K93_11115	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
E2K93_11155	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
E2K93_11160	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
E2K93_11165	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
E2K93_11175	ENOG4105C3W	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity)
E2K93_11205	ENOG4105DIV	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity)
E2K93_11210	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
E2K93_11220	ENOG410839U	amino acid
E2K93_11230	ENOG410839U	amino acid
E2K93_11235	ENOG4105DBV	ornithine carbamoyltransferase
E2K93_11240	ENOG4105C5B	carbamate kinase
E2K93_11250	ENOG4105CD3	dihydroorotase
E2K93_11270	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
E2K93_11275	ENOG4105F1A	Pyruvate formate-lyase
E2K93_11280	ENOG4105C6N	Formate acetyltransferase
E2K93_11285	ENOG4108RE9	Phosphodiesterase
E2K93_11310	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
E2K93_11315	ENOG4105DR5	peptidase
E2K93_11320	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E2K93_11335	ENOG4105EN6	Membrane
E2K93_11340	ENOG41082J7	Rhodanese domain protein
E2K93_11345	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
E2K93_11360	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
E2K93_11390	ENOG4105C3Q	Glycosyl transferase, family 2
E2K93_11395	ENOG4105DQF	Hydrolase
E2K93_11400	ENOG4105BZ8	glutamate synthase
E2K93_11405	ENOG4105CBC	glutamate synthase
E2K93_11410	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
E2K93_11420	ENOG41065U4	response regulator
E2K93_11425	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
E2K93_11440	ENOG4105E39	Enoyl-CoA hydratase
E2K93_11450	ENOG4105QNR	S1 RNA binding domain protein
E2K93_11465	ENOG4107ENK	receptor
E2K93_11485	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E2K93_11490	ENOG4105K46	50S ribosomal protein l27
E2K93_11495	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
E2K93_11500	ENOG4105EAH	synthase
E2K93_11530	ENOG4105D6U	Sodium Glutamate Symporter
E2K93_11545	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
E2K93_11555	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
E2K93_11560	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
E2K93_11575	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
E2K93_11580	ENOG4105CUT	histidyl-tRNA synthetase
E2K93_11585	ENOG4105N21	Membrane
E2K93_11590	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E2K93_11595	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
E2K93_11600	ENOG4105DFG	type I secretion outer membrane protein
E2K93_11605	ENOG41087AY	ADP-Ribose pyrophosphatase
E2K93_11610	ENOG4108SX3	cytoplasmic protein
E2K93_11615	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
E2K93_11620	ENOG4105IPS	esterase
E2K93_11625	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E2K93_11645	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E2K93_11650	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
E2K93_11655	ENOG4105KQT	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity)
E2K93_11665	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
E2K93_11670	ENOG4105MYG	DNA polymerase iii, chi subunit
E2K93_11675	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E2K93_11680	ENOG4108M8S	permease YjgP YjgQ family protein
E2K93_11685	ENOG4108K5H	permease YjgP YjgQ family protein
E2K93_11715	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E2K93_11720	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E2K93_11745	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
E2K93_11755	ENOG4105FCK	Membrane
E2K93_11760	ENOG4105C3J	Cysteine desulfurase
E2K93_11765	ENOG4105WVQ	Fe-S assembly protein IscX
E2K93_11770	ENOG4107R1I	NAD-dependent malic enzyme
E2K93_11805	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
E2K93_11820	ENOG4105N14	lysine exporter protein LysE YggA
E2K93_11830	ENOG4105CE4	GlcNAc 6-P deacetylase
E2K93_11835	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
E2K93_11925	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
E2K93_11930	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
E2K93_11935	ENOG4108Z6B	deaminase
E2K93_11945	ENOG4105CSA	Coproporphyrinogen iii oxidase
E2K93_11950	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
E2K93_11960	ENOG4108VIA	integral membrane protein
E2K93_11965	ENOG4105II7	pyrroline-5-carboxylate reductase
E2K93_11970	ENOG4105DFA	alanine racemase domain protein
E2K93_11975	ENOG4105CZX	twitching motility protein
E2K93_11980	ENOG4105CZX	twitching motility protein
E2K93_11985	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
E2K93_11990	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
E2K93_11995	ENOG4105D7Z	glutathione synthase
E2K93_12000	ENOG4108UJU	UPF0301 protein
E2K93_12005	ENOG4108YZY	peptidylprolyl cis-trans isomerase
E2K93_12010	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
E2K93_12015	ENOG4105Y75	tpr repeat protein
E2K93_12025	ENOG4108IYU	L-aspartate oxidase
E2K93_12030	ENOG4105EMN	RNA polymerase sigma factor
E2K93_12045	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
E2K93_12050	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
E2K93_12055	ENOG4105C3F	Signal peptidase i
E2K93_12060	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
E2K93_12070	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
E2K93_12075	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
E2K93_12080	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
E2K93_12085	ENOG4105BZU	Histidine kinase
E2K93_12090	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E2K93_12095	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E2K93_12100	ENOG4105DXN	mazG family
E2K93_12110	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
E2K93_12115	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
E2K93_12120	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
E2K93_12130	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
E2K93_12135	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
E2K93_12140	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
E2K93_12145	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
E2K93_12150	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
E2K93_12155	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
E2K93_12160	ENOG4108UM1	dedA family
E2K93_12165	ENOG4108K5P	(LipO)protein
E2K93_12170	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E2K93_12175	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
E2K93_12180	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
E2K93_12190	ENOG4105CVG	Homoserine O-transsuccinylase
E2K93_12195	ENOG4105C3R	Methionine synthase
E2K93_12205	ENOG4105Y3E	Modulates RecA activity (By similarity)
E2K93_12210	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
E2K93_12215	ENOG4105CFH	Aspartokinase
E2K93_12220	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
E2K93_12245	ENOG4105ENH	Sulfatase
E2K93_12250	ENOG4105CPN	adenine deaminase
E2K93_12260	ENOG4107QSA	Oxaloacetate decarboxylase
E2K93_12265	ENOG4105D9Q	decarboxylase (Beta subunit)
E2K93_12280	ENOG4108MUX	N-hydroxyarylamine O-acetyltransferase
E2K93_12285	ENOG4105C1J	atp-dependent rna helicase
E2K93_12290	ENOG4105EYM	Major Facilitator superfamily
E2K93_12310	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
E2K93_12320	ENOG4105M85	Bola protein
E2K93_12330	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
E2K93_12335	ENOG4105CH5	extracellular solute-binding protein, family 7
E2K93_12340	ENOG4105RKW	reductase (By
E2K93_12350	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E2K93_12355	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E2K93_12360	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E2K93_12365	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E2K93_12370	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
E2K93_12375	ENOG4105CJ2	(LipO)protein
E2K93_12395	ENOG4105CFC	Transporter
E2K93_12410	ENOG4105CPN	adenine deaminase
E2K93_12505	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E2K93_12520	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
E2K93_12525	ENOG4105EAC	phosphoserine phosphatase
E2K93_12535	ENOG4105CSR	polyphosphate kinase 2
E2K93_12540	ENOG4105EYA	deoxyribonuclease
E2K93_12555	ENOG4105C75	arginyL-tRNA synthetase
E2K93_12560	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
E2K93_12585	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
E2K93_12590	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
E2K93_12595	ENOG4105VIE	preprotein translocase, subunit YajC
E2K93_12600	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E2K93_12605	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E2K93_12645	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
E2K93_12660	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
E2K93_12670	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
E2K93_12675	ENOG4105C3J	Cysteine desulfurase
E2K93_12680	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
E2K93_12685	ENOG4108Z4V	iron-sulfur cluster assembly
E2K93_12690	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
E2K93_12695	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
E2K93_12700	ENOG4108ZIT	Ferredoxin, 2FE-2S
E2K93_12705	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
E2K93_12710	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
E2K93_12715	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
E2K93_12730	ENOG4105CKW	Inner membrane protein yedI
E2K93_12735	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
E2K93_12760	ENOG4105CSV	Glutaminase
E2K93_12765	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
E2K93_12770	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E2K93_12775	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
E2K93_12780	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
E2K93_12790	ENOG4105EIN	peptidylprolyl cis-trans isomerase
E2K93_12805	ENOG4105C26	Dehydrogenase
E2K93_12815	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
E2K93_12830	ENOG4105C8N	cysteinyl-tRNA synthetase
E2K93_12835	ENOG4105EW9	transcriptional regulator AsnC family
E2K93_12840	ENOG4108BPE	-transporting atpase
E2K93_12855	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
E2K93_12860	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E2K93_12870	ENOG4108W1A	pseudouridine synthase
E2K93_12875	ENOG4107S6Z	Na H antiporter
E2K93_12880	ENOG4105D9M	gamma-glutamylcysteine synthetase
E2K93_12895	ENOG4108JU6	CBS domain protein
E2K93_12900	ENOG4106KVJ	cytochrome C assembly protein
E2K93_12905	ENOG4108PJD	permease
E2K93_12910	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E2K93_12925	ENOG4105QYV	Membrane
E2K93_12930	ENOG4105K5M	30s ribosomal protein S16
E2K93_12935	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
E2K93_12940	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
E2K93_12945	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
E2K93_12955	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
E2K93_12960	ENOG4108ZX5	transcriptional regulator
E2K93_12965	ENOG41066YJ	Beta-lactamase
E2K93_12975	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
E2K93_13000	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
E2K93_13005	ENOG4105BZS	acriflavin resistance protein
E2K93_13010	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
E2K93_13020	ENOG4105CQC	Prephenate dehydratase
E2K93_13025	ENOG4105IUQ	nucleoprotein polynucleotide-associated enzyme
E2K93_13035	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
E2K93_13040	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
E2K93_13045	ENOG4105C34	Pseudouridine synthase
E2K93_13060	ENOG4105C28	cystathionine
E2K93_13075	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
E2K93_13080	ENOG4108ZJT	translation initiation factor, Sui1
E2K93_13085	ENOG4105C10	Electron transfer flavoprotein
E2K93_13090	ENOG4105BZJ	Electron transfer flavoprotein
E2K93_13095	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
E2K93_13100	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
E2K93_13110	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
E2K93_13115	ENOG4108YZA	Nitrogen regulatory protein pii
E2K93_13120	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
E2K93_13140	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
E2K93_13170	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
E2K93_13175	ENOG4105QAX	Iron-sulfur
E2K93_13185	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2K93_13190	ENOG4105C34	Pseudouridine synthase
E2K93_13195	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
E2K93_13200	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E2K93_13235	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
E2K93_13255	ENOG4105BZU	Histidine kinase
E2K93_13260	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
E2K93_13270	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
E2K93_13280	ENOG4108VPT	UPF0234 protein
E2K93_13285	ENOG4107RDJ	Sulfotransferase
E2K93_13290	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
E2K93_13300	ENOG4105C8J	)-transporter
E2K93_13305	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
E2K93_13310	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
E2K93_13320	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
E2K93_13325	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
E2K93_13330	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
E2K93_13340	ENOG4105E96	Colicin v production protein
E2K93_13345	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
E2K93_13350	ENOG4108JQ2	peptide transport system atp-binding protein
E2K93_13355	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
E2K93_13360	ENOG4108EU3	peptide transport system, permease
E2K93_13365	ENOG4108I5W	peptide transport system, permease protein
E2K93_13370	ENOG4105DEF	Extracellular solute-binding protein, family 5
E2K93_13375	ENOG4105E51	psp operon transcriptional activator
E2K93_13380	ENOG41087YS	Phage shock protein A
E2K93_13390	ENOG41067S9	phage shock protein C, PspC
E2K93_13395	ENOG4105CM6	amino acid regulated cytosolic protein
E2K93_13400	ENOG4106K28	UPF0283 membrane protein
E2K93_13405	ENOG4105MIR	Phenylalanine 4-monooxygenase
E2K93_13410	ENOG41090A4	Pterin carbinolamine dehydratase
E2K93_13420	ENOG4108RXX	maleylacetoacetate isomerase
E2K93_13450	ENOG4105EJ9	Membrane
E2K93_13455	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
E2K93_13480	ENOG4109015	Biopolymer transport protein exbD tolR
E2K93_13495	ENOG41077A9	carbonic anhydrase
E2K93_13500	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
E2K93_13510	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
E2K93_13515	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
E2K93_13520	ENOG4105DK0	Indole-3-glycerol phosphate synthase
E2K93_13525	ENOG4107QYG	anthranilate phosphoribosyltransferase
E2K93_13530	ENOG4105DDQ	anthranilate synthase
E2K93_13535	ENOG4105CRQ	synthase (Component I)
E2K93_13540	ENOG4105DB7	PHP domain protein
E2K93_13545	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
E2K93_13555	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
E2K93_13560	ENOG4105FE9	pseudouridine synthase
E2K93_13575	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
E2K93_13585	ENOG4105EAQ	(twin-arginine translocation) pathway signal
E2K93_13595	ENOG4105CIS	alcohol dehydrogenase
E2K93_13600	ENOG4105HEI	LysR family (Transcriptional regulator
E2K93_13605	ENOG4108JUA	Transcriptional regulator
E2K93_13615	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
E2K93_13620	ENOG4108UJV	acyl-CoA thioesterase i
E2K93_13625	ENOG4107ZSV	Receptor
E2K93_13640	ENOG4105CA0	peroxidase
E2K93_13655	ENOG4105CHR	reductase
E2K93_13685	ENOG4108YIQ	Alpha beta hydrolase
E2K93_13715	ENOG4105KNA	-acetyltransferase
E2K93_13725	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
E2K93_13745	ENOG4105VFU	Rna-binding protein
E2K93_13750	ENOG41060QA	UPF0267 protein
E2K93_13770	ENOG4108ZNX	Heat shock protein
E2K93_13780	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
E2K93_13785	ENOG4105EFZ	amidohydrolase
E2K93_13790	ENOG4107RBB	ABC transporter, permease
E2K93_13800	ENOG4105C19	ABC transporter
E2K93_13805	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
E2K93_13810	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
E2K93_13815	ENOG4108JU5	Magnesium and cobalt efflux protein
E2K93_13820	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
E2K93_13825	ENOG4105C9A	Phoh family
E2K93_13830	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E2K93_13835	ENOG4105C0A	alcohol dehydrogenase
E2K93_13840	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
E2K93_13880	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E2K93_13925	ENOG4105BZS	acriflavin resistance protein
E2K93_13945	ENOG4105C0H	protease
E2K93_13950	ENOG4105EFX	secretion protein, HlyD family
E2K93_13955	ENOG4105KK7	inner membrane protein YiaW
E2K93_13960	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
E2K93_13975	ENOG4105QV4	Tryptophan halogenase
E2K93_13990	ENOG4105RD7	BadF BadG BcrA BcrD
E2K93_13995	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
E2K93_14000	ENOG4105CE4	GlcNAc 6-P deacetylase
E2K93_14035	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
E2K93_14040	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
E2K93_14045	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
E2K93_14050	ENOG4108YZY	peptidylprolyl cis-trans isomerase
E2K93_14060	ENOG4105CI2	imidazolone-5-propionate hydrolase
E2K93_14070	ENOG4108Q5Y	Membrane
E2K93_14080	ENOG4105BZG	amino acid carrier protein
E2K93_14085	ENOG4105C1J	atp-dependent rna helicase
E2K93_14140	ENOG4105EB3	Histidine kinase
E2K93_14145	ENOG4108IG5	Transcriptional regulator
E2K93_14160	ENOG4105UYK	outer membrane protein a
E2K93_14165	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
E2K93_14175	ENOG4108IPT	Naphthoate synthase
E2K93_14180	ENOG4107QX3	carboxylase
E2K93_14185	ENOG4105C1G	acyl-Coa dehydrogenase
E2K93_14195	ENOG4105CHU	acetyl-coa acetyltransferase
E2K93_14200	ENOG4105C1G	acyl-Coa dehydrogenase
E2K93_14205	ENOG4105E39	Enoyl-CoA hydratase
E2K93_14215	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
E2K93_14220	ENOG4105CHR	reductase
E2K93_14250	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
E2K93_14255	ENOG4105DUX	Transporter
E2K93_14265	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
E2K93_14285	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
E2K93_14310	ENOG4105HDD	phospholipase
E2K93_14320	ENOG4105CHU	acetyl-coa acetyltransferase
E2K93_14325	ENOG4107QNJ	CoA-transferase subunit B
E2K93_14330	ENOG4105D6N	CoA-transferase, subunit a
E2K93_14355	ENOG4108Z66	YbaK ebsC protein
E2K93_14365	ENOG4105VEQ	Cold shock protein
E2K93_14380	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
E2K93_14385	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
E2K93_14390	ENOG4108Z43	UPF0250 protein
E2K93_14400	ENOG4105DZ1	carboxypeptidase
E2K93_14405	ENOG4105K6T	rare lipoprotein A
E2K93_14415	ENOG4105CJN	penicillin-binding protein
E2K93_14420	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
E2K93_14430	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
E2K93_14435	ENOG4108CG9	DNA polymerase III, delta subunit
E2K93_14440	ENOG4108U2H	Rare lipoprotein B
E2K93_14445	ENOG4105C8T	Leucyl-tRNA synthetase
E2K93_14450	ENOG4107PAI	alpha helical protein
E2K93_14455	ENOG4105DAN	ATP-dependent protease
E2K93_14490	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E2K93_14495	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E2K93_14500	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E2K93_14505	ENOG4105GKE	subunit e
E2K93_14510	ENOG4107QIZ	NADH dehydrogenase
E2K93_14515	ENOG4107R0R	NADH dehydrogenase subunit g
E2K93_14520	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
E2K93_14525	ENOG41081QM	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E2K93_14530	ENOG4107UFS	subunit j
E2K93_14535	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E2K93_14540	ENOG4105D65	subunit l
E2K93_14545	ENOG4105C8S	subunit m
E2K93_14550	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E2K93_14585	ENOG4105C1J	atp-dependent rna helicase
E2K93_14600	ENOG4105CIS	alcohol dehydrogenase
E2K93_14605	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
E2K93_14610	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
E2K93_14615	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
E2K93_14620	ENOG4105CE9	30S ribosomal protein S2
E2K93_14625	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
E2K93_14635	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
E2K93_14640	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
E2K93_14645	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
E2K93_14650	ENOG4105KNE	Phosphatidate cytidylyltransferase
E2K93_14655	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
E2K93_14660	ENOG4105DZP	Membrane-associated zinc metalloprotease
E2K93_14670	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
E2K93_14675	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E2K93_14680	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
E2K93_14685	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E2K93_14690	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E2K93_14700	ENOG4105C0B	DNA polymerase III (alpha subunit)
E2K93_14705	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
E2K93_14710	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
E2K93_14715	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
E2K93_14720	ENOG4108YY7	Invasion gene expression up-regulator SirB
E2K93_14725	ENOG41063JG	Transcriptional regulator
E2K93_14735	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
E2K93_14745	ENOG4108Z5K	methylglyoxal synthase
E2K93_14755	ENOG4107RFY	SbcCD D subunit
E2K93_14760	ENOG4105EYH	Exonuclease
E2K93_14765	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
E2K93_14770	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
E2K93_14775	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
E2K93_14780	ENOG4105M2J	Glutaredoxin
E2K93_14785	ENOG4105D3R	alkyl hydroperoxide reductase
E2K93_14795	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
E2K93_14820	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
E2K93_14825	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
E2K93_14830	ENOG4105C9M	aspartyl-trna synthetase
E2K93_14835	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
E2K93_14840	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
E2K93_14845	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
E2K93_14860	ENOG4107YD3	Thioesterase
E2K93_14865	ENOG4105E02	MotA TolQ exbB proton channel
E2K93_14870	ENOG4105M8F	Biopolymer transport protein exbD tolR
E2K93_14880	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
E2K93_14885	ENOG4105KCK	Peptidoglycan-associated lipoprotein
E2K93_14925	ENOG4107ZXI	Rhomboid family
E2K93_14935	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
E2K93_14940	ENOG4105C6T	cysteine synthase
E2K93_14945	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
E2K93_15005	ENOG4107RGH	Aldehyde dehydrogenase
E2K93_15015	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E2K93_15020	ENOG4107RZZ	dna polymerase iii epsilon subunit
E2K93_15060	ENOG4107QPN	acyl-Coa dehydrogenase
E2K93_15065	ENOG4105E7A	Glutamine amidotransferase
E2K93_15075	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
E2K93_15080	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
E2K93_15105	ENOG4105K89	arsenate reductase
E2K93_15110	ENOG4105ERG	peptidase m48, ste24p
E2K93_15125	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2K93_15130	ENOG4105RH4	Glycine cleavage system transcriptional repressor
E2K93_15135	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E2K93_15155	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
E2K93_15160	ENOG4105BZN	citrate synthase
E2K93_15165	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
E2K93_15170	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
E2K93_15175	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
E2K93_15180	ENOG4105E33	succinate dehydrogenase
E2K93_15185	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
E2K93_15190	ENOG4105C7S	Dehydrogenase
E2K93_15215	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
E2K93_15230	ENOG4105DG7	nitrate ABC transporter
E2K93_15235	ENOG4105D7T	ABC transporter
E2K93_15245	ENOG4107QZF	nitrite reductase NADPH large subunit
E2K93_15250	ENOG4105WZK	nitrite reductase NADPH small subunit
E2K93_15260	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
E2K93_15265	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
E2K93_15270	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
E2K93_15310	ENOG4105CX6	glutaminyL-tRNA synthetase
E2K93_15315	ENOG41090R7	Ferric uptake
E2K93_15320	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
E2K93_15325	ENOG4105NNH	LexA regulated protein
E2K93_15335	ENOG4105EV9	Alpha Beta Hydrolase
E2K93_15340	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
E2K93_15345	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
E2K93_15350	ENOG4107UI5	Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity)
E2K93_15355	ENOG4107RUY	(E1 component), alpha subunit
E2K93_15360	ENOG4105CPP	Dehydrogenase, E1 component
E2K93_15385	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
E2K93_15390	ENOG4105D1F	ATP-binding protein
E2K93_15395	ENOG4105DHP	deoxycytidine triphosphate deaminase
E2K93_15400	ENOG4105CHW	UPF0052 protein
E2K93_15430	ENOG4105D5Q	Arginine ornithine antiporter
E2K93_15435	ENOG4108XFH	Transcriptional regulator
E2K93_15450	ENOG4105C9X	ppx gppa phosphatase
E2K93_15480	ENOG4108ZP8	Acetolactate synthase small subunit
E2K93_15485	ENOG4105C7K	acetolactate synthase
E2K93_15490	ENOG4105EY2	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)
E2K93_15495	ENOG4105C5W	Aldolase
E2K93_15500	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
E2K93_15505	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
E2K93_15510	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
E2K93_15515	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
E2K93_15520	ENOG4105DQ5	transport system permease protein
E2K93_15525	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
E2K93_15530	ENOG4105DK2	UPF0207 protein
E2K93_15535	ENOG4105CHM	Aminotransferase
E2K93_15575	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
E2K93_15585	ENOG4105C72	UPF0176 protein
E2K93_15590	ENOG4108R96	Methyltransferase, YaeB family
E2K93_15600	ENOG4105BZU	Histidine kinase
E2K93_15615	ENOG4108VWS	Yaeq family
E2K93_15620	ENOG4108UYE	Lactoylglutathione lyase
E2K93_15650	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
E2K93_15690	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
E2K93_15695	ENOG4105CA0	peroxidase
E2K93_15700	ENOG4105CSM	endonuclease III
E2K93_15705	ENOG4105DZB	Electron transport complex
E2K93_15710	ENOG4108UQQ	Electron transport complex
E2K93_15715	ENOG4105D6A	Electron transport complex
E2K93_15725	ENOG4108R3D	Electron transport complex
E2K93_15730	ENOG4105DGN	Electron transport complex
E2K93_15735	ENOG4108M8H	domain protein
E2K93_15740	ENOG41080IJ	Diacylglycerol kinase
E2K93_15745	ENOG4108JU6	CBS domain protein
E2K93_15755	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
E2K93_15775	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
E2K93_15780	ENOG4105EXN	Sulfate transport protein CysZ
E2K93_15785	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
E2K93_15790	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
E2K93_15795	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
E2K93_15805	ENOG4105K4T	epimerase
E2K93_15820	ENOG4108PZW	LysR family Transcriptional regulator
E2K93_15845	ENOG41081YB	ApbE family
E2K93_15850	ENOG4108J5H	Homocysteine s-methyltransferase
E2K93_15860	ENOG4108S4H	thioesterase Superfamily protein
E2K93_15870	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E2K93_15880	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E2K93_15885	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
E2K93_15890	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
E2K93_15915	ENOG4105CK2	sodium dicarboxylate symporter
E2K93_15925	ENOG4105DHF	Membrane
E2K93_15950	ENOG4105DGU	Histone deacetylase
E2K93_15960	ENOG4105C1J	atp-dependent rna helicase
E2K93_15990	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
E2K93_15995	ENOG4105BZU	Histidine kinase
E2K93_16000	ENOG4105BZU	Histidine kinase
E2K93_16005	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E2K93_16015	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E2K93_16025	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
E2K93_16030	ENOG4105CAT	Cytidine monophosphate kinase
E2K93_16035	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
E2K93_16040	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
E2K93_16050	ENOG4105CFV	Tetratricopeptide repeat protein
E2K93_16055	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
E2K93_16060	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E2K93_16065	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
E2K93_16070	ENOG4105C03	ribonuclease
E2K93_16075	ENOG4105EI2	Pseudouridine synthase
E2K93_16085	ENOG4108Z4X	TRANSCRIPTIONal
E2K93_16090	ENOG4108UHJ	MAF-like protein
E2K93_16095	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
E2K93_16100	ENOG4105VGS	50s ribosomal protein l32
E2K93_16105	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
E2K93_16110	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E2K93_16115	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
E2K93_16120	ENOG4105CHR	reductase
E2K93_16125	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E2K93_16130	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E2K93_16135	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
E2K93_16140	ENOG4105HHA	aminodeoxychorismate lyase
E2K93_16145	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
E2K93_16150	ENOG4107QRG	dna polymerase iii
E2K93_16160	ENOG4105F8V	Hydrolase, tatD family
E2K93_16165	ENOG4108JIC	nucleoside recognition domain protein
E2K93_16200	ENOG4105CR4	methylisocitrate lyase
E2K93_16205	ENOG4105BZN	citrate synthase
E2K93_16210	ENOG4108I0Z	Aconitate hydratase
E2K93_16215	ENOG4105C7F	AcnD-accessory protein PrpF
E2K93_16235	ENOG4108ZGC	gaf domain protein
E2K93_16245	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
E2K93_16250	ENOG4105CN1	protease
E2K93_16255	ENOG4105DFD	Na H antiporter
E2K93_16260	ENOG4105CD8	aminopeptidase N
E2K93_16270	ENOG4105D25	secreted protein
E2K93_16285	ENOG4105C7I	Dehydrogenase
E2K93_16290	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
E2K93_16295	ENOG4105D3G	Pseudouridine synthase
E2K93_16310	ENOG4105CAQ	asparagine synthetase
E2K93_16320	ENOG4108IUW	ABC transporter
E2K93_16325	ENOG4108SDH	ABC, transporter
E2K93_16330	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
E2K93_16335	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
E2K93_16340	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
E2K93_16350	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
E2K93_16355	ENOG4105BZ8	glutamate synthase
E2K93_16395	ENOG4105C7N	Xanthine uracil vitamin C permease
E2K93_16400	ENOG4105Q9Y	Universal stress protein
E2K93_16405	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
E2K93_16420	ENOG4105C59	p-type ATPase
E2K93_16445	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
E2K93_16460	ENOG410829K	Lysine exporter protein (Lyse ygga)
E2K93_16475	ENOG4108RXX	maleylacetoacetate isomerase
E2K93_16480	ENOG4108IG5	Transcriptional regulator
E2K93_16495	ENOG4105KF3	Short-chain dehydrogenase reductase Sdr
E2K93_16500	ENOG4105CHU	acetyl-coa acetyltransferase
E2K93_16510	ENOG4105CHR	reductase
E2K93_16520	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E2K93_16525	ENOG4105EBR	Carboxylesterase
E2K93_16540	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
E2K93_16550	ENOG4105C0A	alcohol dehydrogenase
E2K93_16575	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
E2K93_16590	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
E2K93_16595	ENOG4105CSU	acyl-Coa dehydrogenase
E2K93_16600	ENOG4105CSU	acyl-Coa dehydrogenase
E2K93_16610	ENOG4105DHF	Membrane
E2K93_16635	ENOG4107QI1	Mate efflux family protein
E2K93_16640	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
E2K93_16650	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E2K93_16655	ENOG4105BZU	Histidine kinase
E2K93_16680	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
E2K93_16710	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
E2K93_16715	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
E2K93_16720	ENOG4105HF0	Membrane
E2K93_16730	ENOG4105DVT	helicase
E2K93_16735	ENOG4105CQ2	DNA polymerase
E2K93_16740	ENOG4105C28	cystathionine
E2K93_16745	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
E2K93_16750	ENOG4105W1Y	Transcriptional regulator
E2K93_16765	ENOG4105PGM	cation diffusion facilitator family transporter
E2K93_16790	ENOG4105G6Z	alkaline phosphatase
E2K93_16795	ENOG4107104	thymidine kinase
E2K93_16800	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
E2K93_16805	ENOG4105D9N	nucleoside
E2K93_16810	ENOG4105DBI	uridine monophosphokinase
E2K93_16815	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
E2K93_16820	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
E2K93_16830	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
E2K93_16840	ENOG4108I5U	Uridine phosphorylase
E2K93_16860	ENOG4105C0B	DNA polymerase III (alpha subunit)
E2K93_16885	ENOG4105KJF	protein tyrosine phosphatase
E2K93_16895	ENOG4105C58	cytochrome c oxidase accessory protein ccog
E2K93_16900	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
E2K93_16905	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
E2K93_16910	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E2K93_16915	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
E2K93_16920	ENOG4105CQB	FAD linked oxidase domain protein
E2K93_16930	ENOG4105CIS	alcohol dehydrogenase
E2K93_16935	ENOG4107RDP	Dehydrogenase
E2K93_16950	ENOG4105EZE	Cupin 4 family protein
E2K93_16955	ENOG4107QTF	adenylosuccinate lyase
E2K93_16960	ENOG41075W9	High frequency lysogenization protein HflD homolog
E2K93_16965	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
E2K93_16975	ENOG4108R99	pseudouridine synthase
E2K93_16985	ENOG4105VEQ	Cold shock protein
E2K93_16990	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
E2K93_16995	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E2K93_17010	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
E2K93_17015	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
E2K93_17020	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
E2K93_17025	ENOG4105C3M	thioredoxin reductase
E2K93_17030	ENOG4105DCF	alanine dehydrogenase
E2K93_17035	ENOG4105EW9	transcriptional regulator AsnC family
E2K93_17040	ENOG4105CNU	cell division protein FtsK
E2K93_17045	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
E2K93_17050	ENOG4105D1H	recombination factor protein RarA
E2K93_17055	ENOG4105WMR	Protein CrcB homolog
E2K93_17060	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
E2K93_17085	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
E2K93_17095	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
E2K93_17100	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
E2K93_17105	ENOG4108MN8	Membrane
E2K93_17110	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E2K93_17215	ENOG4105KCV	RNA signal recognition particle 4.5S RNA
E2K93_17220	ENOG4105I4A	GCN5-related N-acetyltransferase
E2K93_17235	ENOG4107VAM	peptidase, m28
E2K93_17260	ENOG4105F1S	paraquat-inducible protein a
E2K93_17265	ENOG4105DY2	Paraquat-inducible protein b
E2K93_17290	ENOG4105EKE	dihydroorotase
E2K93_17295	ENOG4106V8H	Nucleoid-associated protein
E2K93_17300	ENOG4105PAN	UPF0352 protein
E2K93_17345	ENOG4108SA1	esterase
E2K93_17355	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
E2K93_17400	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
E2K93_17410	ENOG4105D6U	Sodium Glutamate Symporter
E2K93_17415	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
E2K93_17420	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
E2K93_17425	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E2K93_17430	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
E2K93_17435	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
E2K93_17440	ENOG4105C5S	asparaginyl-tRNA synthetase
E2K93_17445	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
E2K93_17450	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
E2K93_17455	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
E2K93_17485	ENOG41069NU	Nitroreductase
E2K93_17495	ENOG4105D07	Signal peptide peptidase, SppA
E2K93_17515	ENOG4105VUT	cytoplasmic protein
E2K93_17525	ENOG4105BZG	amino acid carrier protein
E2K93_17545	ENOG4105E0X	reductase
E2K93_17550	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
E2K93_17565	ENOG4105ENH	Sulfatase
E2K93_17570	ENOG41064T2	transcriptional regulator, lysR family
E2K93_17575	ENOG4108UHU	Aldolase
E2K93_17580	ENOG4105CHC	glucokinase (EC 2.7.1.2)
E2K93_17585	ENOG4105C01	Dihydroxy-acid dehydratase
E2K93_17590	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
E2K93_17595	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
E2K93_17600	ENOG4106KNT	transcriptional regulator
E2K93_17605	ENOG4105CA9	Pyruvate kinase
E2K93_17610	ENOG4105CTQ	phosphohexokinase
E2K93_17615	ENOG4105DY9	regulatoR
E2K93_17620	ENOG4108HRK	Histidine kinase
E2K93_17630	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
E2K93_17640	ENOG4105CNM	Receptor
E2K93_17645	ENOG4105K59	histidine triad (HIT) protein