locus-tag	class	description
E2K93_00050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E2K93_00055	COG2897	thiosulfate sulfurtransferase activity
E2K93_00060	COG0322	excinuclease ABC activity
E2K93_00065	COG2197	response regulator
E2K93_00075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2K93_00090	COG0488	(ABC) transporter
E2K93_00100	COG0116	Belongs to the methyltransferase superfamily
E2K93_00100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E2K93_00155	COG1254	Belongs to the acylphosphatase family
E2K93_00160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E2K93_00170	COG1643	Atp-dependent helicase
E2K93_00190	COG0745	RESPONSE REGULATOR receiver
E2K93_00200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E2K93_00205	COG1074	ATP-dependent DNA helicase activity
E2K93_00210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E2K93_00235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2K93_00240	COG2249	NAD(P)H dehydrogenase (quinone) activity
E2K93_00250	COG2814	Major facilitator Superfamily
E2K93_00260	COG2925	Exonuclease
E2K93_00265	COG2084	Dehydrogenase
E2K93_00270	COG0386	Belongs to the glutathione peroxidase family
E2K93_00275	COG0527	aspartate kinase activity
E2K93_00280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E2K93_00290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2K93_00305	COG1185	polyribonucleotide nucleotidyltransferase activity
E2K93_00310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2K93_00345	COG2304	oxidoreductase activity
E2K93_00365	COG0714	Associated with various cellular activities
E2K93_00380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E2K93_00385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E2K93_00390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E2K93_00395	COG0195	Participates in both transcription termination and antitermination
E2K93_00400	COG0779	Required for maturation of 30S ribosomal subunits
E2K93_00425	COG0745	RESPONSE REGULATOR receiver
E2K93_00460	COG0513	Belongs to the DEAD box helicase family
E2K93_00475	COG4974	Belongs to the 'phage' integrase family
E2K93_00490	COG3311	Transcriptional regulator
E2K93_00500	COG0582	viral genome integration into host DNA
E2K93_00510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2K93_00515	COG0149	triose-phosphate isomerase activity
E2K93_00520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E2K93_00525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E2K93_00530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2K93_00535	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E2K93_00540	COG1534	Rna-binding protein
E2K93_00545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2K93_00570	COG2197	response regulator
E2K93_00575	COG4585	Histidine kinase
E2K93_00600	COG0454	-acetyltransferase
E2K93_00605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2K93_00615	COG0505	Belongs to the CarA family
E2K93_00620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E2K93_00625	COG0545	Peptidyl-prolyl cis-trans isomerase
E2K93_00645	COG3038	cytochrome b561
E2K93_00650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E2K93_00655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E2K93_00660	COG2226	methyltransferase
E2K93_00665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2K93_00670	COG0741	lytic transglycosylase activity
E2K93_00670	COG1388	LysM domain
E2K93_00675	COG1757	Na H antiporter
E2K93_00705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E2K93_00710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E2K93_00715	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E2K93_00725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E2K93_00745	COG0307	riboflavin synthase, alpha
E2K93_00750	COG0534	Mate efflux family protein
E2K93_00770	COG0579	oxidoreductase
E2K93_00805	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E2K93_00810	COG0848	biopolymer transport protein
E2K93_00815	COG0811	peptide transport
E2K93_00820	COG0811	peptide transport
E2K93_00860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E2K93_00865	COG0857	belongs to the CobB CobQ family
E2K93_00865	COG0280	phosphate acetyltransferase
E2K93_00890	COG0028	Belongs to the TPP enzyme family
E2K93_00900	COG3012	SEC-C Motif Domain Protein
E2K93_00905	COG2205	protein histidine kinase activity
E2K93_00910	COG0745	RESPONSE REGULATOR receiver
E2K93_00915	COG0708	Exodeoxyribonuclease III
E2K93_00920	COG2226	methyltransferase
E2K93_00925	COG3092	negative regulation of chromosome organization
E2K93_00935	COG1393	Belongs to the ArsC family
E2K93_00945	COG1876	peptidase activity
E2K93_00955	COG0583	DNA-binding transcription factor activity
E2K93_00965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E2K93_00980	COG0006	proline dipeptidase activity
E2K93_00995	COG2350	Protein conserved in bacteria
E2K93_01005	COG0628	permease
E2K93_01010	COG1090	epimerase
E2K93_01015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E2K93_01020	COG4181	ATPase activity
E2K93_01025	COG2755	lipolytic protein G-D-S-L family
E2K93_01030	COG2198	Histidine kinase
E2K93_01030	COG5002	protein histidine kinase activity
E2K93_01030	COG0784	Response regulator, receiver
E2K93_01045	COG0471	metal ion transport
E2K93_01050	COG1472	Belongs to the glycosyl hydrolase 3 family
E2K93_01055	COG1309	transcriptional regulator
E2K93_01075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E2K93_01085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2K93_01090	COG0733	neurotransmitter:sodium symporter activity
E2K93_01095	COG1322	Protein conserved in bacteria
E2K93_01100	COG1506	peptidase
E2K93_01100	COG0823	Involved in the tonB-independent uptake of proteins
E2K93_01120	COG1760	l-serine dehydratase
E2K93_01150	COG2983	Belongs to the UPF0260 family
E2K93_01155	COG2951	lytic endotransglycosylase activity
E2K93_01160	COG3100	YcgL domain-containing protein
E2K93_01170	COG0318	PFAM AMP-dependent synthetase and ligase
E2K93_01190	COG1214	PFAM Peptidase M22, glycoprotease
E2K93_01195	COG1199	ATP-dependent helicase activity
E2K93_01200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E2K93_01215	COG0131	Imidazoleglycerol-phosphate dehydratase
E2K93_01215	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2K93_01220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E2K93_01225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E2K93_01235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E2K93_01235	COG0140	phosphoribosyl-ATP diphosphatase activity
E2K93_01240	COG2153	protein acetylation
E2K93_01260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E2K93_01280	COG0326	Molecular chaperone. Has ATPase activity
E2K93_01285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E2K93_01300	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
E2K93_01305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2K93_01315	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E2K93_01320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E2K93_01325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E2K93_01360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2K93_01365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E2K93_01375	COG0589	response to stress
E2K93_01390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E2K93_01460	COG1088	dTDP-glucose 4,6-dehydratase activity
E2K93_01500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2K93_01520	COG0438	transferase activity, transferring glycosyl groups
E2K93_01585	COG1596	polysaccharide export
E2K93_01665	COG3590	peptidase
E2K93_01670	COG0529	Catalyzes the synthesis of activated sulfate
E2K93_01675	COG3273	potassium ion transport
E2K93_01675	COG0471	metal ion transport
E2K93_01680	COG2895	sulfate adenylyltransferase (ATP) activity
E2K93_01685	COG0175	sulfate reduction
E2K93_01690	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E2K93_01695	COG2835	tetraacyldisaccharide 4'-kinase activity
E2K93_01705	COG1132	(ABC) transporter
E2K93_01710	COG2333	competence protein COMEC
E2K93_01710	COG0658	competence protein
E2K93_01725	COG4591	ABC-type transport system involved in lipoprotein release permease component
E2K93_01735	COG4591	ABC-type transport system involved in lipoprotein release permease component
E2K93_01740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E2K93_01755	COG1335	isochorismatase
E2K93_01760	COG1187	pseudouridine synthase activity
E2K93_01785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E2K93_01790	COG3171	Protein conserved in bacteria
E2K93_01795	COG1194	a g-specific adenine glycosylase
E2K93_01800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E2K93_01820	COG0348	domain, Protein
E2K93_01820	COG3901	Regulator of nitric oxide reductase transcription
E2K93_01870	COG1476	TRANSCRIPTIONal
E2K93_01925	COG1611	Belongs to the LOG family
E2K93_01930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2K93_01940	COG0473	3-isopropylmalate dehydrogenase activity
E2K93_01945	COG1404	Belongs to the peptidase S8 family
E2K93_01950	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E2K93_01965	COG0583	DNA-binding transcription factor activity
E2K93_01980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E2K93_01990	COG1301	dicarboxylic acid transport
E2K93_01995	COG0500	methyltransferase
E2K93_02000	COG0616	signal peptide processing
E2K93_02010	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_02020	COG2890	protein-(glutamine-N5) methyltransferase activity
E2K93_02025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E2K93_02030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E2K93_02045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E2K93_02050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E2K93_02055	COG0193	aminoacyl-tRNA hydrolase activity
E2K93_02065	COG1454	alcohol dehydrogenase
E2K93_02065	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_02075	COG1278	Cold shock
E2K93_02080	COG1022	Amp-dependent synthetase and ligase
E2K93_02085	COG0564	pseudouridine synthase activity
E2K93_02120	COG5002	protein histidine kinase activity
E2K93_02125	COG0745	RESPONSE REGULATOR receiver
E2K93_02140	COG0604	alcohol dehydrogenase
E2K93_02170	COG1472	Belongs to the glycosyl hydrolase 3 family
E2K93_02180	COG3459	Glycosyltransferase 36 associated
E2K93_02185	COG2211	Major facilitator Superfamily
E2K93_02230	COG1472	Belongs to the glycosyl hydrolase 3 family
E2K93_02245	COG2211	Major facilitator Superfamily
E2K93_02250	COG1609	Transcriptional regulator
E2K93_02275	COG0519	Catalyzes the synthesis of GMP from XMP
E2K93_02275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2K93_02285	COG0174	glutamine synthetase
E2K93_02335	COG0488	(ABC) transporter
E2K93_02355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E2K93_02360	COG0513	Belongs to the DEAD box helicase family
E2K93_02370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2K93_02410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E2K93_02420	COG0318	PFAM AMP-dependent synthetase and ligase
E2K93_02450	COG0804	urea catabolic process
E2K93_02455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K93_02485	COG1304	FMN binding
E2K93_02535	COG1136	(ABC) transporter
E2K93_02545	COG2207	Transcriptional regulator
E2K93_02580	COG2151	metal-sulfur cluster biosynthetic enzyme
E2K93_02590	COG2855	membrane
E2K93_02595	COG1960	acyl-CoA dehydrogenase activity
E2K93_02605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E2K93_02610	COG2890	protein-(glutamine-N5) methyltransferase activity
E2K93_02615	COG2840	Smr protein MutS2
E2K93_02620	COG2062	phosphohistidine phosphatase, SixA
E2K93_02625	COG1025	Belongs to the peptidase M16 family
E2K93_02640	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2K93_02640	COG1024	Enoyl-CoA hydratase
E2K93_02645	COG0183	Belongs to the thiolase family
E2K93_02650	COG0714	Associated with various cellular activities
E2K93_02670	COG2304	oxidoreductase activity
E2K93_02695	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E2K93_02700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2K93_02710	COG1215	transferase activity, transferring glycosyl groups
E2K93_02735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E2K93_02740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E2K93_02770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2K93_02775	COG3104	oligopeptide transport
E2K93_02780	COG1404	Belongs to the peptidase S8 family
E2K93_02790	COG1228	amidohydrolase
E2K93_02810	COG4771	TonB-dependent receptor
E2K93_02840	COG1404	Belongs to the peptidase S8 family
E2K93_02875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E2K93_02880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E2K93_02885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2K93_02890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E2K93_02900	COG2853	Lipoprotein
E2K93_02905	COG2204	response regulator
E2K93_02910	COG4191	Histidine kinase
E2K93_02925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E2K93_02930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2K93_02935	COG0126	phosphoglycerate kinase activity
E2K93_02970	COG2914	Belongs to the UPF0125 (RnfH) family
E2K93_02975	COG2867	negative regulation of translational initiation
E2K93_02980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E2K93_03000	COG1716	ATPase activity
E2K93_03000	COG5001	Diguanylate cyclase
E2K93_03015	COG0745	RESPONSE REGULATOR receiver
E2K93_03020	COG2205	protein histidine kinase activity
E2K93_03075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E2K93_03080	COG1047	Peptidyl-prolyl cis-trans
E2K93_03090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E2K93_03095	COG0196	riboflavin kinase activity
E2K93_03100	COG0728	peptidoglycan biosynthetic process
E2K93_03105	COG0268	Binds directly to 16S ribosomal RNA
E2K93_03120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E2K93_03125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E2K93_03130	COG0730	response to heat
E2K93_03145	COG3066	DNA modification
E2K93_03150	COG0676	glucose-6-phosphate 1-epimerase activity
E2K93_03200	COG4964	Belongs to the GSP D family
E2K93_03270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2K93_03275	COG0463	Glycosyl transferase, family 2
E2K93_03285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E2K93_03290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E2K93_03295	COG0497	DNA recombination
E2K93_03300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2K93_03315	COG1595	DNA-templated transcription, initiation
E2K93_03320	COG0583	DNA-binding transcription factor activity
E2K93_03325	COG0306	phosphate transporter
E2K93_03330	COG1392	Phosphate transport regulator
E2K93_03335	COG0704	Plays a role in the regulation of phosphate uptake
E2K93_03340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E2K93_03345	COG0573	inorganic phosphate transmembrane transporter activity
E2K93_03380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2K93_03380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2K93_03385	COG0339	signal peptide processing
E2K93_03390	COG2204	response regulator
E2K93_03420	COG2205	protein histidine kinase activity
E2K93_03420	COG2198	Histidine kinase
E2K93_03420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2K93_03420	COG0784	Response regulator, receiver
E2K93_03425	COG0488	(ABC) transporter
E2K93_03430	COG3590	peptidase
E2K93_03440	COG2119	membrane
E2K93_03445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2K93_03455	COG2974	May be involved in recombination
E2K93_03460	COG1950	PFAM Membrane protein of
E2K93_03465	COG5002	protein histidine kinase activity
E2K93_03470	COG0745	RESPONSE REGULATOR receiver
E2K93_03500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2K93_03500	COG0301	tRNA thio-modification
E2K93_03505	COG1722	exodeoxyribonuclease VII activity
E2K93_03510	COG0142	geranyltranstransferase activity
E2K93_03515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E2K93_03540	COG0443	Heat shock 70 kDa protein
E2K93_03545	COG3437	response regulator, receiver
E2K93_03550	COG2205	protein histidine kinase activity
E2K93_03550	COG3437	response regulator, receiver
E2K93_03550	COG4999	Histidine kinase
E2K93_03550	COG3850	Histidine kinase
E2K93_03555	COG2814	Major facilitator Superfamily
E2K93_03565	COG1451	nucleotide metabolic process
E2K93_03575	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E2K93_03605	COG0583	DNA-binding transcription factor activity
E2K93_03615	COG2205	protein histidine kinase activity
E2K93_03620	COG0745	RESPONSE REGULATOR receiver
E2K93_03635	COG1404	Belongs to the peptidase S8 family
E2K93_03655	COG1132	(ABC) transporter
E2K93_03680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2K93_03690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2K93_03710	COG0463	Glycosyl transferase, family 2
E2K93_03725	COG1442	glycosyl transferase family 8
E2K93_03725	COG1216	Glycosyl transferase, family 2
E2K93_03760	COG0798	PFAM Bile acid sodium symporter
E2K93_03765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E2K93_03775	COG1902	pentaerythritol trinitrate reductase activity
E2K93_03785	COG4232	protein-disulfide reductase activity
E2K93_03795	COG1979	alcohol dehydrogenase
E2K93_03800	COG2095	MarC family integral membrane protein
E2K93_03805	COG4946	Tricorn protease homolog
E2K93_03805	COG1506	peptidase
E2K93_03805	COG0823	Involved in the tonB-independent uptake of proteins
E2K93_03815	COG1119	ATPase activity
E2K93_03820	COG1304	FMN binding
E2K93_03825	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2K93_03835	COG0738	Major facilitator superfamily
E2K93_03855	COG2721	sulfolactate sulfo-lyase activity
E2K93_03885	COG3119	arylsulfatase activity
E2K93_03890	COG3119	arylsulfatase activity
E2K93_03895	COG3119	arylsulfatase activity
E2K93_03900	COG3119	arylsulfatase activity
E2K93_03905	COG3119	arylsulfatase activity
E2K93_03915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2K93_03915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2K93_03925	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E2K93_03930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_03940	COG1538	Outer membrane efflux protein
E2K93_03945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K93_03950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K93_03955	COG0006	proline dipeptidase activity
E2K93_03960	COG3079	Belongs to the UPF0149 family
E2K93_03970	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E2K93_03975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E2K93_03980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E2K93_03985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2K93_03990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2K93_04010	COG3706	GGDEF domain
E2K93_04015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E2K93_04020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E2K93_04025	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E2K93_04030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E2K93_04035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2K93_04040	COG0716	FMN binding
E2K93_04045	COG0513	Belongs to the DEAD box helicase family
E2K93_04065	COG3022	response to hydroperoxide
E2K93_04070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E2K93_04080	COG1272	protein, Hemolysin III
E2K93_04095	COG1131	(ABC) transporter
E2K93_04100	COG1444	tRNA N-acetyltransferase activity
E2K93_04105	COG4459	periplasmic nitrate reductase
E2K93_04110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2K93_04120	COG0243	molybdopterin cofactor binding
E2K93_04125	COG3043	anaerobic respiration
E2K93_04130	COG3005	denitrification pathway
E2K93_04140	COG0303	'Molybdopterin
E2K93_04150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2K93_04155	COG0746	molybdenum cofactor guanylyltransferase activity
E2K93_04160	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2K93_04165	COG0315	cyclic pyranopterin monophosphate synthase activity
E2K93_04175	COG0314	molybdopterin synthase activity
E2K93_04190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E2K93_04195	COG3130	regulation of translation
E2K93_04200	COG3530	Putative quorum-sensing-regulated virulence factor
E2K93_04205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2K93_04210	COG3118	belongs to the thioredoxin family
E2K93_04260	COG2885	chlorophyll binding
E2K93_04260	COG3047	cAMP biosynthetic process
E2K93_04265	COG0745	RESPONSE REGULATOR receiver
E2K93_04270	COG2205	protein histidine kinase activity
E2K93_04280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E2K93_04295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E2K93_04305	COG0302	gtp cyclohydrolase
E2K93_04320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2K93_04335	COG4221	oxidoreductase activity
E2K93_04345	COG0415	Belongs to the DNA photolyase family
E2K93_04355	COG3806	Anti-sigma factor
E2K93_04360	COG1595	DNA-templated transcription, initiation
E2K93_04370	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E2K93_04375	COG3040	lipid binding
E2K93_04380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K93_04385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_04420	COG0788	formyltetrahydrofolate deformylase activity
E2K93_04440	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E2K93_04450	COG0800	Aldolase
E2K93_04455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2K93_04460	COG2271	Major facilitator Superfamily
E2K93_04495	COG2186	Transcriptional regulator
E2K93_04515	COG1454	alcohol dehydrogenase
E2K93_04520	COG0778	Nitroreductase
E2K93_04535	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E2K93_04535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2K93_04540	COG1560	Kdo2-lipid A biosynthetic process
E2K93_04560	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E2K93_04600	COG4991	sh3 domain protein
E2K93_04610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2K93_04625	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E2K93_04630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2K93_04635	COG0473	3-isopropylmalate dehydrogenase activity
E2K93_04640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2K93_04645	COG0066	3-isopropylmalate dehydratase activity
E2K93_04655	COG3267	Type II secretory pathway component ExeA
E2K93_04655	COG3409	Peptidoglycan-binding domain 1 protein
E2K93_04660	COG0617	tRNA 3'-terminal CCA addition
E2K93_04665	COG1832	CoA-binding protein
E2K93_04670	COG1968	undecaprenyl-diphosphatase activity
E2K93_04680	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E2K93_04685	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E2K93_04690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E2K93_04695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E2K93_04700	COG1610	YqeY-like protein
E2K93_04705	COG0358	DNA primase activity
E2K93_04710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2K93_04725	COG3706	GGDEF domain
E2K93_04735	COG0582	viral genome integration into host DNA
E2K93_04775	COG1696	Membrane protein involved in D-alanine export
E2K93_04810	COG1404	Belongs to the peptidase S8 family
E2K93_04830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E2K93_04850	COG0741	lytic transglycosylase activity
E2K93_04870	COG0733	neurotransmitter:sodium symporter activity
E2K93_04875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E2K93_04875	COG0116	Belongs to the methyltransferase superfamily
E2K93_04880	COG1280	lysine exporter protein (LysE YggA)
E2K93_04885	COG1793	dna ligase
E2K93_04905	COG2827	Endonuclease containing a URI domain
E2K93_04920	COG3842	ATPase activity
E2K93_04930	COG1840	ABC-type Fe3 transport system, periplasmic component
E2K93_04975	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_04985	COG4948	Mandelate Racemase Muconate Lactonizing
E2K93_04995	COG1388	LysM domain
E2K93_04995	COG1376	ErfK ybiS ycfS ynhG family protein
E2K93_05040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2K93_05055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K93_05065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E2K93_05070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E2K93_05075	COG0083	homoserine kinase activity
E2K93_05090	COG3141	response to X-ray
E2K93_05110	COG1473	amidohydrolase
E2K93_05125	COG1404	Belongs to the peptidase S8 family
E2K93_05125	COG1404	Belongs to the peptidase S8 family
E2K93_05140	COG0583	DNA-binding transcription factor activity
E2K93_05155	COG4251	negative regulation of phosphorylation
E2K93_05155	COG3706	GGDEF domain
E2K93_05155	COG5001	Diguanylate cyclase
E2K93_05155	COG2203	Gaf domain
E2K93_05165	COG4946	Tricorn protease homolog
E2K93_05165	COG0823	Involved in the tonB-independent uptake of proteins
E2K93_05165	COG1506	peptidase
E2K93_05170	COG0163	prenyltransferase activity
E2K93_05175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2K93_05185	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E2K93_05200	COG4459	periplasmic nitrate reductase
E2K93_05205	COG3005	denitrification pathway
E2K93_05210	COG0243	molybdopterin cofactor binding
E2K93_05215	COG3381	protein complex oligomerization
E2K93_05245	COG0183	Belongs to the thiolase family
E2K93_05250	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2K93_05250	COG1024	Enoyl-CoA hydratase
E2K93_05260	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E2K93_05265	COG0175	sulfate reduction
E2K93_05270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2K93_05275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E2K93_05305	COG1842	Phage shock protein A
E2K93_05325	COG0735	belongs to the Fur family
E2K93_05335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E2K93_05340	COG0305	Participates in initiation and elongation during chromosome replication
E2K93_05345	COG2719	SpoVR family
E2K93_05350	COG2718	Belongs to the UPF0229 family
E2K93_05355	COG2766	serine protein kinase
E2K93_05370	COG1595	DNA-templated transcription, initiation
E2K93_05375	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E2K93_05385	COG1984	allophanate hydrolase subunit 2
E2K93_05390	COG2832	Protein of unknown function (DUF454)
E2K93_05395	COG4807	Protein conserved in bacteria
E2K93_05405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E2K93_05420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E2K93_05425	COG0254	rRNA binding
E2K93_05445	COG0339	signal peptide processing
E2K93_05460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2K93_05475	COG1741	Belongs to the pirin family
E2K93_05485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E2K93_05490	COG2986	histidine ammonia-lyase
E2K93_05505	COG0435	Glutathione S-transferase
E2K93_05515	COG0037	tRNA processing
E2K93_05535	COG0330	HflC and HflK could
E2K93_05540	COG0330	HflC and HflK could
E2K93_05550	COG2133	pyrroloquinoline quinone binding
E2K93_05560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2K93_05565	COG0456	acetyltransferase
E2K93_05570	COG1490	D-aminoacyl-tRNA deacylase activity
E2K93_05580	COG1295	ribonuclease BN
E2K93_05615	COG0174	glutamine synthetase
E2K93_05625	COG3852	Histidine kinase
E2K93_05640	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E2K93_05650	COG1509	lysine 2,3-aminomutase activity
E2K93_05675	COG0459	protein refolding
E2K93_05680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E2K93_05690	COG1324	tolerance protein
E2K93_05695	COG4232	protein-disulfide reductase activity
E2K93_05705	COG0511	ligase activity, forming carbon-carbon bonds
E2K93_05710	COG0439	Biotin carboxylase
E2K93_05735	COG2814	Major facilitator Superfamily
E2K93_05740	COG3217	Mosc domain protein beta barrel domain protein
E2K93_05740	COG0633	Ferredoxin
E2K93_05755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2K93_05775	COG1966	Carbon starvation protein
E2K93_05780	COG1765	OsmC-like protein
E2K93_05790	COG3954	Phosphoribulokinase
E2K93_05795	COG0203	ribosomal protein L17
E2K93_05800	COG0202	RNA polymerase activity
E2K93_05810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E2K93_05815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E2K93_05825	COG0201	protein transport
E2K93_05830	COG0200	Binds to the 23S rRNA
E2K93_05835	COG1841	ribosomal large subunit assembly
E2K93_05840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E2K93_05845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E2K93_05850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E2K93_05855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E2K93_05860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E2K93_05865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E2K93_05870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E2K93_05890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E2K93_05900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E2K93_05905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E2K93_05910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E2K93_05915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E2K93_05920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E2K93_05925	COG0089	rRNA binding
E2K93_05930	COG0088	Forms part of the polypeptide exit tunnel
E2K93_05935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E2K93_05940	COG0051	transcription antitermination factor activity, RNA binding
E2K93_05945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E2K93_05960	COG1902	pentaerythritol trinitrate reductase activity
E2K93_05960	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2K93_05970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E2K93_05995	COG0668	transmembrane transport
E2K93_06030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2K93_06035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2K93_06045	COG4772	TonB-dependent receptor
E2K93_06050	COG0640	Transcriptional regulator
E2K93_06055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_06075	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E2K93_06085	COG2175	clavaminate synthase activity
E2K93_06095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2K93_06100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2K93_06105	COG0049	tRNA binding
E2K93_06110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E2K93_06115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E2K93_06120	COG0085	RNA polymerase activity
E2K93_06125	COG0222	ribosome binding
E2K93_06130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E2K93_06140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E2K93_06150	COG0250	Participates in transcription elongation, termination and antitermination
E2K93_06155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2K93_06180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2K93_06210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E2K93_06210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E2K93_06215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E2K93_06220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E2K93_06235	COG0545	Peptidyl-prolyl cis-trans isomerase
E2K93_06240	COG2900	Belongs to the SlyX family
E2K93_06245	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E2K93_06250	COG0488	(ABC) transporter
E2K93_06255	COG2824	Alkylphosphonate utilization operon protein PhnA
E2K93_06265	COG0429	hydrolase of the alpha beta-hydrolase fold
E2K93_06280	COG1218	3'(2'),5'-bisphosphate nucleotidase
E2K93_06285	COG0494	nUDIX hydrolase
E2K93_06290	COG1011	Hydrolase
E2K93_06295	COG2195	Cleaves the N-terminal amino acid of tripeptides
E2K93_06300	COG1309	transcriptional regulator
E2K93_06305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E2K93_06310	COG2003	Belongs to the UPF0758 family
E2K93_06315	COG2321	neutral zinc metallopeptidase
E2K93_06320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E2K93_06325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E2K93_06330	COG1704	LemA family
E2K93_06335	COG0501	Belongs to the peptidase M48B family
E2K93_06340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E2K93_06345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E2K93_06350	COG1309	transcriptional regulator
E2K93_06355	COG3642	lipopolysaccharide core region biosynthetic process
E2K93_06360	COG0859	PFAM glycosyl transferase family 9
E2K93_06380	COG1519	Transferase
E2K93_06390	COG1063	alcohol dehydrogenase
E2K93_06420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E2K93_06430	COG0514	ATP-dependent DNA helicase (RecQ)
E2K93_06435	COG2050	protein possibly involved in aromatic compounds catabolism
E2K93_06440	COG2962	Rard protein
E2K93_06460	COG1404	Belongs to the peptidase S8 family
E2K93_06490	COG2271	Major facilitator Superfamily
E2K93_06495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2K93_06510	COG4269	membrane
E2K93_06515	COG0210	DNA helicase
E2K93_06525	COG1011	Hydrolase
E2K93_06535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E2K93_06540	COG0019	diaminopimelate decarboxylase activity
E2K93_06550	COG1965	Belongs to the frataxin family
E2K93_06555	COG0181	hydroxymethylbilane synthase activity
E2K93_06565	COG2959	enzyme of heme biosynthesis
E2K93_06590	COG0583	DNA-binding transcription factor activity
E2K93_06620	COG1006	Multisubunit Na H antiporter MnhC subunit
E2K93_06625	COG0651	ATP synthesis coupled electron transport
E2K93_06630	COG0651	ATP synthesis coupled electron transport
E2K93_06640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E2K93_06640	COG2111	Na H antiporter
E2K93_06660	COG2937	Belongs to the GPAT DAPAT family
E2K93_06675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E2K93_06680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E2K93_06685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2K93_06690	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E2K93_06715	COG1612	heme a metabolic process
E2K93_06720	COG0109	protoheme IX farnesyltransferase activity
E2K93_06730	COG0217	transcriptional regulatory protein
E2K93_06740	COG0625	glutathione transferase activity
E2K93_06745	COG0726	polysaccharide deacetylase
E2K93_06750	COG0534	Mate efflux family protein
E2K93_06755	COG2814	Major facilitator Superfamily
E2K93_06760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E2K93_06760	COG0316	Belongs to the HesB IscA family
E2K93_06770	COG1040	competence protein
E2K93_06775	COG0596	Alpha beta hydrolase
E2K93_06785	COG0668	transmembrane transport
E2K93_06800	COG0583	DNA-binding transcription factor activity
E2K93_06815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E2K93_06835	COG1561	YicC-like family, N-terminal region
E2K93_06845	COG3132	Protein of unknown function, DUF480
E2K93_06855	COG0583	DNA-binding transcription factor activity
E2K93_06865	COG1917	Cupin 2, conserved barrel domain protein
E2K93_06865	COG2207	Transcriptional regulator
E2K93_06870	COG1346	cytolysis
E2K93_06885	COG0668	transmembrane transport
E2K93_06910	COG2193	ferroxidase activity
E2K93_06930	COG1448	Aminotransferase
E2K93_06945	COG0194	GDP metabolic process
E2K93_06950	COG1758	RNA polymerase activity
E2K93_06955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2K93_06965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2K93_06970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E2K93_06975	COG2226	methyltransferase
E2K93_06995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2K93_07000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2K93_07005	COG0805	protein transport
E2K93_07040	COG3118	belongs to the thioredoxin family
E2K93_07045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E2K93_07050	COG1187	pseudouridine synthase activity
E2K93_07055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E2K93_07060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E2K93_07065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E2K93_07070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2K93_07075	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E2K93_07080	COG4942	peptidase
E2K93_07090	COG2861	carbohydrate metabolic process
E2K93_07095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K93_07155	COG0482	sulfurtransferase activity
E2K93_07180	COG1045	serine acetyltransferase
E2K93_07185	COG0438	transferase activity, transferring glycosyl groups
E2K93_07195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2K93_07200	COG1596	polysaccharide export
E2K93_07210	COG0489	protein tyrosine kinase activity
E2K93_07220	COG3267	Type II secretory pathway component ExeA
E2K93_07220	COG3409	Peptidoglycan-binding domain 1 protein
E2K93_07225	COG2204	response regulator
E2K93_07230	COG4191	Histidine kinase
E2K93_07245	COG0745	RESPONSE REGULATOR receiver
E2K93_07250	COG4251	negative regulation of phosphorylation
E2K93_07260	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_07300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2K93_07320	COG3618	amidohydrolase
E2K93_07330	COG0457	Tetratricopeptide repeat
E2K93_07360	COG3119	arylsulfatase activity
E2K93_07370	COG1802	Transcriptional regulator
E2K93_07385	COG4948	Mandelate Racemase Muconate Lactonizing
E2K93_07390	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_07410	COG0330	HflC and HflK could
E2K93_07425	COG3119	arylsulfatase activity
E2K93_07430	COG3119	arylsulfatase activity
E2K93_07435	COG3734	2-keto-3-deoxy-galactonokinase
E2K93_07445	COG2017	converts alpha-aldose to the beta-anomer
E2K93_07460	COG0800	Aldolase
E2K93_07465	COG3734	2-keto-3-deoxy-galactonokinase
E2K93_07470	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_07490	COG3250	beta-galactosidase activity
E2K93_07500	COG2706	6-phosphogluconolactonase activity
E2K93_07530	COG3119	arylsulfatase activity
E2K93_07535	COG3119	arylsulfatase activity
E2K93_07560	COG3250	beta-galactosidase activity
E2K93_07570	COG3119	arylsulfatase activity
E2K93_07595	COG3119	arylsulfatase activity
E2K93_07600	COG3119	arylsulfatase activity
E2K93_07605	COG3250	beta-galactosidase activity
E2K93_07610	COG3119	arylsulfatase activity
E2K93_07620	COG3119	arylsulfatase activity
E2K93_07625	COG3250	beta-galactosidase activity
E2K93_07635	COG2186	Transcriptional regulator
E2K93_07640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2K93_07645	COG1085	galactose-1-phosphate uridylyltransferase
E2K93_07650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E2K93_07670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2K93_07705	COG1349	DNA-binding transcription factor activity
E2K93_07710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2K93_07720	COG0625	glutathione transferase activity
E2K93_07725	COG3265	gluconokinase activity
E2K93_07730	COG0673	inositol 2-dehydrogenase activity
E2K93_07740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2K93_07750	COG0640	Transcriptional regulator
E2K93_07755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E2K93_07755	COG0678	peroxiredoxin activity
E2K93_07760	COG4628	conserved protein (DUF2132)
E2K93_07785	COG2095	MarC family integral membrane protein
E2K93_07795	COG3068	Protein conserved in bacteria
E2K93_07800	COG3360	Dodecin
E2K93_07805	COG0742	ribosomal rna small subunit methyltransferase
E2K93_07810	COG0552	protein localization to endoplasmic reticulum
E2K93_07815	COG2884	Cell division ATP-binding protein ftsE
E2K93_07820	COG2177	Part of the ABC transporter FtsEX involved in
E2K93_07840	COG0210	DNA helicase
E2K93_07855	COG0129	dihydroxy-acid dehydratase activity
E2K93_07860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E2K93_07870	COG0606	chelatase, subunit chli
E2K93_07875	COG0583	DNA-binding transcription factor activity
E2K93_07880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E2K93_07885	COG0252	asparaginase activity
E2K93_07890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E2K93_07895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E2K93_07900	COG0668	transmembrane transport
E2K93_07905	COG1946	Acyl-CoA thioesterase
E2K93_07935	COG0295	cytidine deaminase activity
E2K93_07965	COG1082	Xylose isomerase domain protein TIM barrel
E2K93_07990	COG4989	oxidoreductase activity
E2K93_08005	COG1476	TRANSCRIPTIONal
E2K93_08025	COG1640	4-alpha-glucanotransferase
E2K93_08035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E2K93_08040	COG0058	SHG alpha-glucan phosphorylase activity
E2K93_08055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2K93_08100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2K93_08105	COG0662	Cupin 2, conserved barrel domain protein
E2K93_08140	COG3738	Protein conserved in bacteria
E2K93_08145	COG0384	phenazine biosynthesis protein PhzF
E2K93_08185	COG2264	protein methyltransferase activity
E2K93_08190	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E2K93_08215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E2K93_08255	COG0726	polysaccharide deacetylase
E2K93_08295	COG1671	Belongs to the UPF0178 family
E2K93_08300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E2K93_08315	COG0745	RESPONSE REGULATOR receiver
E2K93_08325	COG3064	Membrane
E2K93_08340	COG0633	Ferredoxin
E2K93_08350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E2K93_08360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E2K93_08365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E2K93_08370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E2K93_08390	COG1475	DNA binding
E2K93_08395	COG1192	Involved in chromosome partitioning
E2K93_08400	COG0357	Ribosomal RNA small subunit methyltransferase G
E2K93_08405	COG0445	tRNA wobble uridine modification
E2K93_08410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E2K93_08415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E2K93_08420	COG0706	membrane insertase activity
E2K93_08425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E2K93_08430	COG0594	ribonuclease P activity
E2K93_08435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E2K93_08440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E2K93_08445	COG0592	DNA-directed DNA polymerase activity
E2K93_08455	COG0187	DNA topoisomerase II activity
E2K93_08460	COG0752	glycyl-tRNA synthetase alpha subunit
E2K93_08465	COG0751	glycine-tRNA ligase activity
E2K93_08470	COG0425	Belongs to the sulfur carrier protein TusA family
E2K93_08485	COG1739	Uncharacterized protein family UPF0029
E2K93_08490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E2K93_08495	COG0569	domain protein
E2K93_08500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2K93_08500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2K93_08520	COG0758	DNA mediated transformation
E2K93_08525	COG2922	Belongs to the Smg family
E2K93_08560	COG3083	sulfuric ester hydrolase activity
E2K93_08565	COG3047	cAMP biosynthetic process
E2K93_08580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E2K93_08625	COG3078	GTPase activator activity
E2K93_08640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2K93_08660	COG0189	ligase activity
E2K93_08675	COG0745	RESPONSE REGULATOR receiver
E2K93_08695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E2K93_08705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2K93_08705	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2K93_08710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2K93_08725	COG0742	ribosomal rna small subunit methyltransferase
E2K93_08735	COG0450	alkyl hydroperoxide reductase
E2K93_08740	COG0583	DNA-binding transcription factor activity
E2K93_08750	COG0678	peroxiredoxin activity
E2K93_08755	COG1528	Iron-storage protein
E2K93_08760	COG2081	HI0933 family
E2K93_08815	COG0668	transmembrane transport
E2K93_08820	COG0351	phosphomethylpyrimidine kinase
E2K93_08820	COG0352	thiamine-phosphate diphosphorylase activity
E2K93_08850	COG0346	lactoylglutathione lyase activity
E2K93_08885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2K93_08920	COG1335	isochorismatase
E2K93_08940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2K93_08950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2K93_08970	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_08975	COG2814	Major facilitator Superfamily
E2K93_08995	COG1960	acyl-CoA dehydrogenase activity
E2K93_09005	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_09015	COG1335	isochorismatase
E2K93_09025	COG4774	siderophore transport
E2K93_09050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K93_09060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2K93_09065	COG0066	3-isopropylmalate dehydratase activity
E2K93_09095	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_09110	COG0477	Major facilitator Superfamily
E2K93_09120	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_09130	COG3153	acetyltransferase
E2K93_09130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2K93_09150	COG2188	Transcriptional regulator
E2K93_09170	COG0457	Tetratricopeptide repeat
E2K93_09175	COG4771	TonB-dependent receptor
E2K93_09185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K93_09210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2K93_09235	COG0154	amidase activity
E2K93_09240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K93_09250	COG1944	ATP diphosphatase activity
E2K93_09275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2K93_09280	COG1024	Enoyl-CoA hydratase
E2K93_09280	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2K93_09300	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_09350	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_09360	COG2301	Belongs to the HpcH HpaI aldolase family
E2K93_09370	COG1960	acyl-CoA dehydrogenase activity
E2K93_09375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K93_09380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K93_09395	COG0277	FAD linked oxidase domain protein
E2K93_09405	COG2130	NADP-dependent
E2K93_09410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2K93_09440	COG2030	dehydratase
E2K93_09445	COG2301	Belongs to the HpcH HpaI aldolase family
E2K93_09510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E2K93_09520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2K93_09525	COG1228	amidohydrolase
E2K93_09530	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E2K93_09535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E2K93_09545	COG2267	carboxylic ester hydrolase activity
E2K93_09550	COG2205	protein histidine kinase activity
E2K93_09555	COG0745	RESPONSE REGULATOR receiver
E2K93_09585	COG1929	Belongs to the glycerate kinase type-1 family
E2K93_09590	COG2183	response to ionizing radiation
E2K93_09595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2K93_09600	COG0745	RESPONSE REGULATOR receiver
E2K93_09615	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E2K93_09620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E2K93_09625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E2K93_09630	COG3031	protein transport across the cell outer membrane
E2K93_09640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E2K93_09645	COG1459	type II secretion system
E2K93_09650	COG2165	general secretion pathway protein
E2K93_09660	COG2165	general secretion pathway protein
E2K93_09665	COG4795	General secretion pathway protein
E2K93_09670	COG3156	type II secretion system protein K
E2K93_09680	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E2K93_09690	COG0584	glycerophosphoryl diester phosphodiesterase
E2K93_09695	COG0688	phosphatidylethanolamine metabolic process
E2K93_09700	COG1162	GTPase activity
E2K93_09705	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E2K93_09725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E2K93_09730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E2K93_09730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E2K93_09735	COG0802	atpase or kinase
E2K93_09740	COG0860	N-Acetylmuramoyl-L-alanine amidase
E2K93_09750	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E2K93_09755	COG1923	regulation of RNA biosynthetic process
E2K93_09760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E2K93_09765	COG0330	HflC and HflK could
E2K93_09770	COG0330	HflC and HflK could
E2K93_09775	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E2K93_09780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E2K93_09800	COG0281	malic enzyme
E2K93_09810	COG0626	cystathionine gamma-synthase activity
E2K93_09815	COG0527	aspartate kinase activity
E2K93_09815	COG0460	homoserine dehydrogenase
E2K93_09830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2K93_09835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2K93_09840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2K93_09845	COG0137	argininosuccinate synthase activity
E2K93_09855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E2K93_09885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E2K93_09890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E2K93_09895	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E2K93_09910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E2K93_09925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K93_09945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E2K93_09970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E2K93_09995	COG3038	cytochrome b561
E2K93_10000	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E2K93_10005	COG0583	DNA-binding transcription factor activity
E2K93_10020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E2K93_10030	COG4783	chaperone-mediated protein folding
E2K93_10045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2K93_10045	COG1648	precorrin-2 dehydrogenase activity
E2K93_10050	COG2264	protein methyltransferase activity
E2K93_10060	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E2K93_10065	COG0138	bifunctional purine biosynthesis protein purh
E2K93_10075	COG0151	Belongs to the GarS family
E2K93_10080	COG0724	RNA recognition motif
E2K93_10140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2K93_10155	COG2814	Major facilitator Superfamily
E2K93_10165	COG1131	(ABC) transporter
E2K93_10170	COG0842	Transport permease protein
E2K93_10175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E2K93_10180	COG0438	transferase activity, transferring glycosyl groups
E2K93_10185	COG1301	dicarboxylic acid transport
E2K93_10190	COG0076	glutamate decarboxylase activity
E2K93_10195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E2K93_10200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E2K93_10205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E2K93_10210	COG0617	tRNA 3'-terminal CCA addition
E2K93_10220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E2K93_10225	COG1489	DNA binding
E2K93_10235	COG0668	transmembrane transport
E2K93_10250	COG1643	Atp-dependent helicase
E2K93_10255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2K93_10260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E2K93_10265	COG0540	Belongs to the ATCase OTCase family
E2K93_10275	COG0038	chloride channel
E2K93_10285	COG0316	Belongs to the HesB IscA family
E2K93_10320	COG0557	exoribonuclease II activity
E2K93_10330	COG0360	Binds together with S18 to 16S ribosomal RNA
E2K93_10335	COG2965	DNA replication, synthesis of RNA primer
E2K93_10340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E2K93_10345	COG0359	binds to the 23S rRNA
E2K93_10365	COG1077	Cell shape determining protein MreB Mrl
E2K93_10370	COG1792	Involved in formation and maintenance of cell shape
E2K93_10375	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E2K93_10380	COG0424	maF-like protein
E2K93_10385	COG1530	ribonuclease E activity
E2K93_10395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2K93_10400	COG0312	modulator of DNA gyrase
E2K93_10410	COG0312	modulator of DNA gyrase
E2K93_10415	COG2239	Acts as a magnesium transporter
E2K93_10420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2K93_10425	COG1660	Displays ATPase and GTPase activities
E2K93_10430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2K93_10435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E2K93_10440	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2K93_10445	COG1137	ATPase activity
E2K93_10460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E2K93_10485	COG1127	ABC transporter
E2K93_10490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2K93_10495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E2K93_10500	COG2854	intermembrane phospholipid transfer
E2K93_10510	COG5007	Belongs to the BolA IbaG family
E2K93_10515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E2K93_10520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K93_10525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K93_10535	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E2K93_10540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E2K93_10545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E2K93_10550	COG0723	plastoquinol--plastocyanin reductase activity
E2K93_10555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E2K93_10560	COG2857	Cytochrome c1
E2K93_10565	COG0625	glutathione transferase activity
E2K93_10570	COG2969	positive regulation of protein catabolic process
E2K93_10585	COG2823	Periplasmic or secreted lipoprotein
E2K93_10590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E2K93_10595	COG0792	nuclease activity
E2K93_10605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E2K93_10625	COG0415	Belongs to the DNA photolyase family
E2K93_10640	COG2610	gluconate transmembrane transporter activity
E2K93_10650	COG3137	Salt-induced outer membrane protein
E2K93_10655	COG5002	protein histidine kinase activity
E2K93_10655	COG2205	protein histidine kinase activity
E2K93_10655	COG0784	Response regulator, receiver
E2K93_10665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E2K93_10670	COG2001	Belongs to the MraZ family
E2K93_10675	COG0275	rRNA processing
E2K93_10685	COG0768	penicillin binding
E2K93_10695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E2K93_10700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2K93_10710	COG0772	Belongs to the SEDS family
E2K93_10720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2K93_10730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E2K93_10735	COG0849	cell division
E2K93_10740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E2K93_10745	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E2K93_10755	COG0739	heme binding
E2K93_10760	COG0653	protein targeting
E2K93_10775	COG0583	DNA-binding transcription factor activity
E2K93_10790	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E2K93_10805	COG1459	type II secretion system
E2K93_10810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E2K93_10840	COG2186	Transcriptional regulator
E2K93_10845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E2K93_10850	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2K93_10855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2K93_10885	COG1049	propionate catabolic process, 2-methylcitrate cycle
E2K93_10900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K93_10920	COG0004	ammonium transporteR
E2K93_10935	COG0039	L-malate dehydrogenase activity
E2K93_10940	COG1438	arginine binding
E2K93_10945	COG2837	iron assimilation
E2K93_10960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E2K93_10965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E2K93_10970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2K93_10975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E2K93_10980	COG3178	'Phosphotransferase
E2K93_11000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E2K93_11005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E2K93_11015	COG2072	flavoprotein involved in K transport
E2K93_11020	COG1960	acyl-CoA dehydrogenase activity
E2K93_11025	COG0745	RESPONSE REGULATOR receiver
E2K93_11030	COG0848	biopolymer transport protein
E2K93_11045	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E2K93_11050	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2K93_11055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2K93_11060	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2K93_11070	COG1138	Cytochrome C-type biogenesis protein
E2K93_11095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E2K93_11100	COG0659	secondary active sulfate transmembrane transporter activity
E2K93_11105	COG3313	Fe-S protein
E2K93_11115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2K93_11155	COG3483	tryptophan 2,3-dioxygenase activity
E2K93_11160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K93_11165	COG3844	kynureninase activity
E2K93_11175	COG1917	Cupin 2, conserved barrel domain protein
E2K93_11190	COG0657	acetylesterase activity
E2K93_11195	COG0583	DNA-binding transcription factor activity
E2K93_11205	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E2K93_11210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2K93_11220	COG0531	amino acid
E2K93_11225	COG2957	Belongs to the agmatine deiminase family
E2K93_11230	COG0531	amino acid
E2K93_11235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2K93_11250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2K93_11270	COG0405	Gamma-glutamyltransferase
E2K93_11275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E2K93_11280	COG1882	Formate acetyltransferase
E2K93_11285	COG0622	Phosphoesterase
E2K93_11315	COG0739	heme binding
E2K93_11320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E2K93_11340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2K93_11345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E2K93_11390	COG1215	transferase activity, transferring glycosyl groups
E2K93_11395	COG0561	phosphatase activity
E2K93_11400	COG0493	'glutamate synthase
E2K93_11405	COG0069	glutamate synthase activity
E2K93_11405	COG0070	glutamate synthase
E2K93_11405	COG0067	glutamate synthase
E2K93_11410	COG1469	GTP cyclohydrolase I activity
E2K93_11420	COG0745	RESPONSE REGULATOR receiver
E2K93_11440	COG1024	Enoyl-CoA hydratase
E2K93_11450	COG2996	Protein conserved in bacteria
E2K93_11485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E2K93_11490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E2K93_11495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E2K93_11500	COG0142	geranyltranstransferase activity
E2K93_11530	COG0786	glutamate:sodium symporter activity
E2K93_11535	COG1301	dicarboxylic acid transport
E2K93_11545	COG1404	Belongs to the peptidase S8 family
E2K93_11555	COG0105	UTP biosynthetic process
E2K93_11560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E2K93_11565	COG1388	LysM domain
E2K93_11565	COG0791	NLP P60 protein
E2K93_11580	COG0124	histidyl-tRNA synthetase
E2K93_11585	COG2976	Protein conserved in bacteria
E2K93_11590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2K93_11595	COG1160	GTP binding
E2K93_11600	COG1538	Outer membrane efflux protein
E2K93_11605	COG0494	nUDIX hydrolase
E2K93_11610	COG3151	Protein conserved in bacteria
E2K93_11620	COG3150	esterase
E2K93_11625	COG0187	DNA topoisomerase II activity
E2K93_11650	COG0204	Acyl-transferase
E2K93_11655	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E2K93_11665	COG0525	valine-tRNA ligase activity
E2K93_11670	COG2927	DNA polymerase III (CHI subunit)
E2K93_11675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2K93_11680	COG0795	lipopolysaccharide-transporting ATPase activity
E2K93_11685	COG0795	lipopolysaccharide-transporting ATPase activity
E2K93_11715	COG0517	IMP dehydrogenase activity
E2K93_11715	COG0516	GMP reductase activity
E2K93_11720	COG0519	Catalyzes the synthesis of GMP from XMP
E2K93_11720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2K93_11745	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E2K93_11755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2K93_11765	COG2975	iron-sulfur cluster assembly
E2K93_11770	COG0281	malic enzyme
E2K93_11805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E2K93_11820	COG1280	lysine exporter protein (LysE YggA)
E2K93_11830	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E2K93_11835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E2K93_11925	COG0047	phosphoribosylformylglycinamidine synthase activity
E2K93_11925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E2K93_11930	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E2K93_11935	COG0590	tRNA wobble adenosine to inosine editing
E2K93_11945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2K93_11950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E2K93_11960	COG0762	integral membrane protein
E2K93_11965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E2K93_11970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E2K93_11985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E2K93_11990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E2K93_11995	COG0189	ligase activity
E2K93_12015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E2K93_12025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E2K93_12030	COG1595	DNA-templated transcription, initiation
E2K93_12045	COG3086	response to oxidative stress
E2K93_12050	COG0481	GTPase activity
E2K93_12055	COG0681	Belongs to the peptidase S26 family
E2K93_12060	COG0571	ribonuclease III activity
E2K93_12070	COG1381	Involved in DNA repair and RecF pathway recombination
E2K93_12095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2K93_12100	COG3956	TIGRFAM MazG family protein
E2K93_12110	COG0432	Pfam Uncharacterised protein family UPF0047
E2K93_12115	COG0504	CTP synthase activity
E2K93_12130	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E2K93_12140	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E2K93_12150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E2K93_12155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2K93_12160	COG1238	metal cluster binding
E2K93_12165	COG4942	peptidase
E2K93_12165	COG1388	LysM domain
E2K93_12170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2K93_12175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E2K93_12180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E2K93_12190	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E2K93_12195	COG0646	methionine synthase
E2K93_12195	COG1410	methionine synthase
E2K93_12205	COG2137	regulation of response to DNA damage stimulus
E2K93_12210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2K93_12215	COG0527	aspartate kinase activity
E2K93_12220	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E2K93_12245	COG3119	arylsulfatase activity
E2K93_12250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E2K93_12265	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E2K93_12270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E2K93_12285	COG0513	Belongs to the DEAD box helicase family
E2K93_12290	COG2814	Major facilitator Superfamily
E2K93_12320	COG0271	Belongs to the BolA IbaG family
E2K93_12330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2K93_12330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E2K93_12335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2K93_12340	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E2K93_12360	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E2K93_12365	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E2K93_12370	COG2871	sodium ion transport
E2K93_12375	COG1477	protein flavinylation
E2K93_12395	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E2K93_12410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E2K93_12505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E2K93_12520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E2K93_12525	COG0560	Phosphoserine phosphatase
E2K93_12535	COG2326	polyphosphate kinase activity
E2K93_12540	COG0084	hydrolase, TatD family'
E2K93_12555	COG0018	arginyl-trna synthetase
E2K93_12560	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E2K93_12585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E2K93_12590	COG0343	queuine tRNA-ribosyltransferase activity
E2K93_12595	COG1862	Preprotein translocase
E2K93_12600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2K93_12605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2K93_12625	COG1794	racemase activity, acting on amino acids and derivatives
E2K93_12640	COG1288	antiporter activity
E2K93_12645	COG1648	precorrin-2 dehydrogenase activity
E2K93_12645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2K93_12655	COG0483	inositol monophosphate 1-phosphatase activity
E2K93_12670	COG1959	2 iron, 2 sulfur cluster binding
E2K93_12675	COG1104	cysteine desulfurase activity
E2K93_12680	COG0822	iron-sulfur transferase activity
E2K93_12695	COG0443	Heat shock 70 kDa protein
E2K93_12705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E2K93_12710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E2K93_12715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2K93_12715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2K93_12730	COG2354	Protein conserved in bacteria
E2K93_12735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E2K93_12760	COG2066	Belongs to the glutaminase family
E2K93_12765	COG0544	peptidyl-prolyl cis-trans isomerase activity
E2K93_12770	COG0740	serine-type endopeptidase activity
E2K93_12775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E2K93_12780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E2K93_12790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2K93_12805	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_12840	COG3101	peptidyl-lysine hydroxylation
E2K93_12860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2K93_12870	COG0564	pseudouridine synthase activity
E2K93_12875	COG1757	Na H antiporter
E2K93_12895	COG4536	flavin adenine dinucleotide binding
E2K93_12900	COG4137	Cytochrome C assembly protein
E2K93_12905	COG0701	Predicted permease
E2K93_12910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E2K93_12920	COG3485	protocatechuate 3,4-dioxygenase
E2K93_12925	COG0697	spore germination
E2K93_12930	COG0228	four-way junction DNA binding
E2K93_12935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E2K93_12945	COG0335	large ribosomal subunit rRNA binding
E2K93_12955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2K93_12975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2K93_12980	COG1605	Chorismate mutase
E2K93_12980	COG0287	Prephenate dehydrogenase
E2K93_13005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_13010	COG2824	Alkylphosphonate utilization operon protein PhnA
E2K93_13020	COG1605	Chorismate mutase
E2K93_13020	COG0077	Prephenate dehydratase
E2K93_13025	COG3122	Protein conserved in bacteria
E2K93_13035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2K93_13045	COG0564	pseudouridine synthase activity
E2K93_13060	COG0626	cystathionine gamma-synthase activity
E2K93_13070	COG0028	Belongs to the TPP enzyme family
E2K93_13075	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2K93_13080	COG0023	Translation Initiation Factor
E2K93_13100	COG0259	pyridoxamine-phosphate oxidase activity
E2K93_13105	COG0612	Peptidase, M16
E2K93_13115	COG0347	Belongs to the P(II) protein family
E2K93_13120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E2K93_13140	COG0303	'Molybdopterin
E2K93_13170	COG0243	molybdopterin cofactor binding
E2K93_13170	COG3383	formate dehydrogenase (NAD+) activity
E2K93_13175	COG0437	4 iron, 4 sulfur cluster binding
E2K93_13185	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2K93_13190	COG0564	pseudouridine synthase activity
E2K93_13200	COG0542	response to heat
E2K93_13235	COG1404	Belongs to the peptidase S8 family
E2K93_13255	COG3850	Histidine kinase
E2K93_13255	COG5002	protein histidine kinase activity
E2K93_13270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2K93_13280	COG1666	GTP binding
E2K93_13285	COG0457	Tetratricopeptide repeat
E2K93_13290	COG0653	protein targeting
E2K93_13295	COG0653	protein targeting
E2K93_13300	COG0733	neurotransmitter:sodium symporter activity
E2K93_13310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E2K93_13320	COG0101	tRNA pseudouridine synthase activity
E2K93_13325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E2K93_13330	COG0285	dihydrofolate synthase activity
E2K93_13340	COG1286	toxin biosynthetic process
E2K93_13345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E2K93_13355	COG4172	Belongs to the ABC transporter superfamily
E2K93_13360	COG4171	peptide transport system, permease
E2K93_13365	COG4168	peptide transport system, permease
E2K93_13370	COG0747	negative chemotaxis
E2K93_13375	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E2K93_13380	COG1842	Phage shock protein A
E2K93_13390	COG1983	PspC domain protein
E2K93_13395	COG3106	COG3106 Predicted ATPase
E2K93_13400	COG3768	UPF0283 membrane protein
E2K93_13410	COG2154	pterin-4-alpha-carbinolamine dehydratase
E2K93_13420	COG0625	glutathione transferase activity
E2K93_13450	COG0730	response to heat
E2K93_13470	COG0811	peptide transport
E2K93_13475	COG0811	peptide transport
E2K93_13480	COG0848	biopolymer transport protein
E2K93_13495	COG0288	reversible hydration of carbon dioxide
E2K93_13500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2K93_13510	COG0159	tryptophan synthase activity
E2K93_13530	COG0512	Glutamine amidotransferase of anthranilate synthase
E2K93_13535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E2K93_13545	COG0009	L-threonylcarbamoyladenylate synthase
E2K93_13555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E2K93_13560	COG1187	pseudouridine synthase activity
E2K93_13575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2K93_13585	COG3108	Peptidase M15
E2K93_13590	COG0668	transmembrane transport
E2K93_13595	COG0604	alcohol dehydrogenase
E2K93_13600	COG0583	DNA-binding transcription factor activity
E2K93_13605	COG3604	Transcriptional regulator
E2K93_13615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2K93_13615	COG1017	nitric oxide dioxygenase activity
E2K93_13620	COG2755	lipolytic protein G-D-S-L family
E2K93_13625	COG4771	TonB-dependent receptor
E2K93_13640	COG1858	cytochrome C peroxidase
E2K93_13655	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_13685	COG0596	Alpha beta hydrolase
E2K93_13725	COG0494	nUDIX hydrolase
E2K93_13745	COG0724	RNA recognition motif
E2K93_13770	COG0071	Belongs to the small heat shock protein (HSP20) family
E2K93_13780	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E2K93_13785	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E2K93_13790	COG0577	efflux transmembrane transporter activity
E2K93_13800	COG1136	(ABC) transporter
E2K93_13805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K93_13810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E2K93_13815	COG4535	Mg2 and Co2 transporter CorC
E2K93_13825	COG1702	phosphate starvation-inducible protein PhoH
E2K93_13830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2K93_13835	COG1454	alcohol dehydrogenase
E2K93_13840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K93_13855	COG1595	DNA-templated transcription, initiation
E2K93_13880	COG0505	Belongs to the CarA family
E2K93_13890	COG2076	Multidrug Resistance protein
E2K93_13925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_13945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K93_13950	COG1566	PFAM secretion protein HlyD family protein
E2K93_13960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E2K93_13990	COG2971	BadF BadG BcrA BcrD
E2K93_13995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2K93_14000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E2K93_14035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E2K93_14040	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E2K93_14045	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E2K93_14050	COG1047	Peptidyl-prolyl cis-trans
E2K93_14060	COG1228	amidohydrolase
E2K93_14070	COG0697	spore germination
E2K93_14080	COG1115	amino acid carrier protein
E2K93_14085	COG0513	Belongs to the DEAD box helicase family
E2K93_14135	COG0745	RESPONSE REGULATOR receiver
E2K93_14140	COG2205	protein histidine kinase activity
E2K93_14145	COG1309	transcriptional regulator
E2K93_14155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_14175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E2K93_14180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2K93_14185	COG1960	acyl-CoA dehydrogenase activity
E2K93_14195	COG0183	Belongs to the thiolase family
E2K93_14200	COG1960	acyl-CoA dehydrogenase activity
E2K93_14205	COG1024	Enoyl-CoA hydratase
E2K93_14210	COG1024	Enoyl-CoA hydratase
E2K93_14220	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_14250	COG2176	DNA-directed DNA polymerase activity
E2K93_14255	COG3104	oligopeptide transport
E2K93_14265	COG0546	phosphoglycolate phosphatase activity
E2K93_14285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E2K93_14320	COG0183	Belongs to the thiolase family
E2K93_14325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2K93_14330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E2K93_14355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E2K93_14365	COG1278	Cold shock
E2K93_14380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E2K93_14385	COG0321	lipoyl(octanoyl) transferase activity
E2K93_14390	COG2921	Belongs to the UPF0250 family
E2K93_14400	COG1686	Belongs to the peptidase S11 family
E2K93_14405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E2K93_14415	COG0768	penicillin binding
E2K93_14420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E2K93_14430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E2K93_14435	COG1466	dna polymerase III delta subunit
E2K93_14440	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
E2K93_14445	COG0495	leucyl-tRNA aminoacylation
E2K93_14450	COG2888	peptidyl-tyrosine sulfation
E2K93_14455	COG1067	ATP-dependent peptidase activity
E2K93_14490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K93_14495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K93_14500	COG0649	NAD binding
E2K93_14500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K93_14505	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E2K93_14515	COG1034	ATP synthesis coupled electron transport
E2K93_14520	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E2K93_14525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K93_14530	COG0839	Belongs to the complex I subunit 6 family
E2K93_14535	COG0713	ATP synthesis coupled electron transport
E2K93_14540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E2K93_14550	COG1007	ATP synthesis coupled electron transport
E2K93_14585	COG0513	Belongs to the DEAD box helicase family
E2K93_14590	COG1024	Enoyl-CoA hydratase
E2K93_14600	COG0604	alcohol dehydrogenase
E2K93_14605	COG2171	N-acyltransferase activity
E2K93_14610	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E2K93_14615	COG0024	Methionine aminopeptidase
E2K93_14620	COG0052	Belongs to the universal ribosomal protein uS2 family
E2K93_14625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E2K93_14635	COG0528	UMP kinase activity
E2K93_14640	COG0233	cytoplasmic translational termination
E2K93_14645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E2K93_14650	COG0575	Belongs to the CDS family
E2K93_14655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E2K93_14660	COG0750	zinc metalloprotease
E2K93_14675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2K93_14680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2K93_14690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2K93_14705	COG0825	malonyl-CoA metabolic process
E2K93_14710	COG0037	tRNA processing
E2K93_14715	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E2K93_14720	COG3094	Invasion gene expression up-regulator, SirB
E2K93_14725	COG2912	Transglutaminase-like superfamily
E2K93_14735	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E2K93_14745	COG1803	Methylglyoxal synthase
E2K93_14755	COG0420	3'-5' exonuclease activity
E2K93_14760	COG0419	ATPase involved in DNA repair
E2K93_14770	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2K93_14775	COG2186	Transcriptional regulator
E2K93_14780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E2K93_14785	COG0450	alkyl hydroperoxide reductase
E2K93_14795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E2K93_14820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2K93_14825	COG2226	methyltransferase
E2K93_14830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E2K93_14835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E2K93_14840	COG0632	four-way junction helicase activity
E2K93_14845	COG2255	four-way junction helicase activity
E2K93_14860	COG0824	Thioesterase
E2K93_14865	COG0811	peptide transport
E2K93_14885	COG2885	chlorophyll binding
E2K93_14925	COG0457	Tetratricopeptide repeat
E2K93_14925	COG0705	Rhomboid family
E2K93_14935	COG0405	Gamma-glutamyltransferase
E2K93_14940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E2K93_14945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2K93_15015	COG0328	RNA-DNA hybrid ribonuclease activity
E2K93_15020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E2K93_15060	COG1960	acyl-CoA dehydrogenase activity
E2K93_15065	COG0121	glutamine amidotransferase
E2K93_15075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E2K93_15080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E2K93_15105	COG1393	Belongs to the ArsC family
E2K93_15110	COG4783	chaperone-mediated protein folding
E2K93_15125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2K93_15130	COG2716	regulation of RNA biosynthetic process
E2K93_15135	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E2K93_15165	COG2009	succinate dehydrogenase
E2K93_15170	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E2K93_15175	COG1053	succinate dehydrogenase
E2K93_15185	COG0567	Dehydrogenase, E1 component
E2K93_15190	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2K93_15215	COG2201	protein-glutamate methylesterase activity
E2K93_15220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K93_15220	COG1116	anion transmembrane transporter activity
E2K93_15225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K93_15230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K93_15235	COG1116	anion transmembrane transporter activity
E2K93_15245	COG2146	nitrite reductase [NAD(P)H] activity
E2K93_15245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2K93_15250	COG2146	nitrite reductase [NAD(P)H] activity
E2K93_15255	COG0243	molybdopterin cofactor binding
E2K93_15260	COG1648	precorrin-2 dehydrogenase activity
E2K93_15260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2K93_15265	COG0045	succinate-CoA ligase (ADP-forming) activity
E2K93_15270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E2K93_15280	COG1505	serine-type exopeptidase activity
E2K93_15310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2K93_15315	COG0735	belongs to the Fur family
E2K93_15320	COG0716	FMN binding
E2K93_15335	COG0596	Alpha beta hydrolase
E2K93_15345	COG0033	Phosphoglucomutase
E2K93_15355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E2K93_15360	COG0022	dehydrogenase e1 component
E2K93_15385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2K93_15385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2K93_15395	COG0717	Belongs to the dCTP deaminase family
E2K93_15430	COG0531	amino acid
E2K93_15435	COG1309	transcriptional regulator
E2K93_15450	COG0248	Ppx GppA phosphatase
E2K93_15455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E2K93_15480	COG0440	acetolactate synthase activity
E2K93_15485	COG0028	Belongs to the TPP enzyme family
E2K93_15490	COG3724	N-succinylarginine dihydrolase activity
E2K93_15495	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E2K93_15500	COG4206	TonB-dependent receptor
E2K93_15510	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E2K93_15520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2K93_15525	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E2K93_15530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E2K93_15535	COG0436	Aminotransferase
E2K93_15575	COG0442	prolyl-tRNA aminoacylation
E2K93_15590	COG1720	tRNA m6t6A37 methyltransferase activity
E2K93_15615	COG4681	YaeQ
E2K93_15620	COG0346	lactoylglutathione lyase activity
E2K93_15650	COG0823	Involved in the tonB-independent uptake of proteins
E2K93_15650	COG4946	Tricorn protease homolog
E2K93_15650	COG1506	peptidase
E2K93_15695	COG1858	cytochrome C peroxidase
E2K93_15700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E2K93_15705	COG4660	Part of a membrane complex involved in electron transport
E2K93_15715	COG4658	electron transport chain
E2K93_15720	COG4656	Part of a membrane complex involved in electron transport
E2K93_15725	COG2878	Part of a membrane complex involved in electron transport
E2K93_15730	COG4657	Part of a membrane complex involved in electron transport
E2K93_15735	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E2K93_15740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E2K93_15745	COG4536	flavin adenine dinucleotide binding
E2K93_15755	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E2K93_15775	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E2K93_15780	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
E2K93_15785	COG1196	nuclear chromosome segregation
E2K93_15795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E2K93_15805	COG0702	epimerase
E2K93_15820	COG0583	DNA-binding transcription factor activity
E2K93_15850	COG2040	homocysteine
E2K93_15860	COG1607	acyl-coa hydrolase
E2K93_15870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E2K93_15875	COG3273	potassium ion transport
E2K93_15875	COG0471	metal ion transport
E2K93_15880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E2K93_15890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2K93_15915	COG1301	dicarboxylic acid transport
E2K93_15925	COG2311	Membrane
E2K93_15950	COG0123	including yeast histone deacetylase and acetoin utilization protein
E2K93_15960	COG0513	Belongs to the DEAD box helicase family
E2K93_15990	COG1404	Belongs to the peptidase S8 family
E2K93_15995	COG2205	protein histidine kinase activity
E2K93_15995	COG5002	protein histidine kinase activity
E2K93_15995	COG0784	Response regulator, receiver
E2K93_16005	COG2204	response regulator
E2K93_16025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E2K93_16030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E2K93_16035	COG0539	negative regulation of cytoplasmic translation
E2K93_16040	COG0776	regulation of translation
E2K93_16050	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E2K93_16055	COG0284	orotidine-5'-phosphate decarboxylase activity
E2K93_16060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E2K93_16065	COG1555	photosystem II stabilization
E2K93_16070	COG1530	ribonuclease E activity
E2K93_16075	COG0564	pseudouridine synthase activity
E2K93_16085	COG0789	Transcriptional regulator
E2K93_16095	COG1399	metal-binding, possibly nucleic acid-binding protein
E2K93_16100	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E2K93_16105	COG0416	fatty acid biosynthetic process
E2K93_16110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2K93_16120	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_16130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2K93_16135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E2K93_16140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E2K93_16145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E2K93_16160	COG0084	hydrolase, TatD family'
E2K93_16165	COG2715	membrane protein required for spore maturation
E2K93_16200	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E2K93_16205	COG0372	Belongs to the citrate synthase family
E2K93_16235	COG1956	GAF domain-containing protein
E2K93_16245	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E2K93_16250	COG0793	Belongs to the peptidase S41A family
E2K93_16260	COG0308	aminopeptidase N
E2K93_16285	COG2902	Dehydrogenase
E2K93_16290	COG0167	dihydroorotate dehydrogenase activity
E2K93_16295	COG0564	pseudouridine synthase activity
E2K93_16310	COG0367	asparagine synthase
E2K93_16320	COG4555	ABC transporter
E2K93_16325	COG1668	transmembrane transport
E2K93_16330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E2K93_16335	COG0072	phenylalanine-tRNA ligase activity
E2K93_16335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2K93_16340	COG0776	regulation of translation
E2K93_16350	COG0674	pyruvate-flavodoxin oxidoreductase activity
E2K93_16350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E2K93_16355	COG0493	'glutamate synthase
E2K93_16370	COG1280	lysine exporter protein (LysE YggA)
E2K93_16395	COG2252	PERMEase
E2K93_16405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2K93_16420	COG2217	Heavy metal translocating P-type atpase
E2K93_16445	COG3278	Belongs to the heme-copper respiratory oxidase family
E2K93_16460	COG1280	lysine exporter protein (LysE YggA)
E2K93_16475	COG0625	glutathione transferase activity
E2K93_16495	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_16500	COG0183	Belongs to the thiolase family
E2K93_16520	COG1902	pentaerythritol trinitrate reductase activity
E2K93_16520	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2K93_16525	COG2272	Belongs to the type-B carboxylesterase lipase family
E2K93_16530	COG2211	Major facilitator Superfamily
E2K93_16535	COG4771	TonB-dependent receptor
E2K93_16550	COG1454	alcohol dehydrogenase
E2K93_16555	COG0824	Thioesterase
E2K93_16590	COG2130	NADP-dependent
E2K93_16595	COG1960	acyl-CoA dehydrogenase activity
E2K93_16600	COG1960	acyl-CoA dehydrogenase activity
E2K93_16610	COG2311	Membrane
E2K93_16635	COG0534	Mate efflux family protein
E2K93_16640	COG0556	nucleotide-excision repair
E2K93_16680	COG4106	trans-aconitate 2-methyltransferase activity
E2K93_16690	COG1716	ATPase activity
E2K93_16690	COG5001	Diguanylate cyclase
E2K93_16715	COG0602	queuosine metabolic process
E2K93_16720	COG0730	response to heat
E2K93_16730	COG1199	ATP-dependent helicase activity
E2K93_16735	COG0417	DNA replication proofreading
E2K93_16740	COG0626	cystathionine gamma-synthase activity
E2K93_16745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2K93_16750	COG0789	Transcriptional regulator
E2K93_16765	COG1230	cation diffusion facilitator family transporter
E2K93_16790	COG1785	Belongs to the alkaline phosphatase family
E2K93_16795	COG1435	thymidine kinase activity
E2K93_16800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E2K93_16805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E2K93_16810	COG0572	uridine kinase
E2K93_16820	COG0813	purine-nucleoside phosphorylase activity
E2K93_16830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2K93_16840	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E2K93_16860	COG0587	DNA-directed DNA polymerase activity
E2K93_16885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2K93_16895	COG0348	domain, Protein
E2K93_16900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K93_16910	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E2K93_16915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E2K93_16915	COG0574	Belongs to the PEP-utilizing enzyme family
E2K93_16920	COG0277	FAD linked oxidase domain protein
E2K93_16920	COG0247	lactate metabolic process
E2K93_16930	COG0604	alcohol dehydrogenase
E2K93_16935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E2K93_16950	COG2850	peptidyl-arginine hydroxylation
E2K93_16955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E2K93_16965	COG0482	sulfurtransferase activity
E2K93_16975	COG1187	pseudouridine synthase activity
E2K93_16985	COG1278	Cold shock
E2K93_16990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E2K93_16995	COG0542	response to heat
E2K93_17010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E2K93_17015	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E2K93_17025	COG0492	ferredoxin-NADP+ reductase activity
E2K93_17030	COG0686	Belongs to the AlaDH PNT family
E2K93_17040	COG0531	amino acid
E2K93_17040	COG1674	ftsk spoiiie
E2K93_17045	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E2K93_17050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E2K93_17055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E2K93_17060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E2K93_17085	COG2920	part of a sulfur-relay system
E2K93_17095	COG2923	Belongs to the DsrF TusC family
E2K93_17105	COG0670	Belongs to the BI1 family
E2K93_17110	COG0519	Catalyzes the synthesis of GMP from XMP
E2K93_17130	COG4282	regulation of fungal-type cell wall biogenesis
E2K93_17215	COG5507	3-demethylubiquinone-9 3-methyltransferase
E2K93_17220	COG0454	-acetyltransferase
E2K93_17235	COG2234	aminopeptidase activity
E2K93_17260	COG2995	paraquat-inducible protein a
E2K93_17265	COG3008	intermembrane lipid transfer
E2K93_17295	COG3081	Nucleoid-associated protein
E2K93_17300	COG3082	Protein of unknown function (DUF1414)
E2K93_17345	COG2819	hydrolase of the alpha beta superfamily
E2K93_17355	COG2067	long-chain fatty acid transport protein
E2K93_17380	COG2304	oxidoreductase activity
E2K93_17400	COG0714	Associated with various cellular activities
E2K93_17410	COG0786	glutamate:sodium symporter activity
E2K93_17415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E2K93_17420	COG2226	methyltransferase
E2K93_17420	COG1073	alpha beta
E2K93_17425	COG0156	8-amino-7-oxononanoate synthase activity
E2K93_17430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E2K93_17435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2K93_17440	COG0017	Asparaginyl-tRNA synthetase
E2K93_17445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K93_17450	COG0577	efflux transmembrane transporter activity
E2K93_17450	COG1136	(ABC) transporter
E2K93_17455	COG0577	efflux transmembrane transporter activity
E2K93_17455	COG1136	(ABC) transporter
E2K93_17485	COG0778	Nitroreductase
E2K93_17495	COG0616	signal peptide processing
E2K93_17515	COG3139	Protein of unknown function (DUF1315)
E2K93_17525	COG1115	amino acid carrier protein
E2K93_17530	COG2866	Carboxypeptidase
E2K93_17545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2K93_17550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E2K93_17565	COG3119	arylsulfatase activity
E2K93_17575	COG0800	Aldolase
E2K93_17585	COG0129	dihydroxy-acid dehydratase activity
E2K93_17590	COG0363	glucosamine-6-phosphate deaminase activity
E2K93_17595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E2K93_17600	COG1737	Transcriptional regulator
E2K93_17605	COG0469	pyruvate kinase activity
E2K93_17610	COG0205	6-phosphofructokinase activity
E2K93_17615	COG3279	Response regulator of the LytR AlgR family
E2K93_17620	COG3275	phosphorelay sensor kinase activity
E2K93_17630	COG3201	nicotinamide mononucleotide transporter
E2K93_17640	COG4773	Receptor
E2K93_17645	COG0537	adenosine 5'-monophosphoramidase activity