locus-tag	class	description
Tharo_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Tharo_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Tharo_0003	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tharo_0010	ENOG41084HI	prevent-host-death family
Tharo_0018	ENOG4105UGU	tonB-dependent Receptor
Tharo_0019	ENOG4108VKG	metal-dependent hydrolase
Tharo_0020	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
Tharo_0021	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Tharo_0022	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
Tharo_0023	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Tharo_0024	ENOG4105DXI	Major Facilitator superfamily
Tharo_0026	ENOG4105DR4	Methyltransferase
Tharo_0030	ENOG4105EGS	Mechanosensitive ion channel
Tharo_0032	ENOG4105RK9	auxin efflux carrier
Tharo_0034	ENOG4105C9Q	fumarate hydratase class II
Tharo_0038	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
Tharo_0043	ENOG4105DH7	May be involved in recombination (By similarity)
Tharo_0045	ENOG4105I08	Pseudouridine synthase
Tharo_0049	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Tharo_0052	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Tharo_0053	ENOG4105D0M	Protease HtpX homolog
Tharo_0054	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Tharo_0055	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Tharo_0057	ENOG4105C79	DNA protecting protein DprA
Tharo_0058	ENOG4108RPN	Protein smg homolog
Tharo_0059	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Tharo_0060	ENOG4107RA9	decarboxylase
Tharo_0061	ENOG4105J0Q	Transcriptional regulator
Tharo_0064	ENOG4105C0H	protease
Tharo_0065	ENOG4105KA7	cytochrome C
Tharo_0067	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Tharo_0069	ENOG4105D65	subunit l
Tharo_0070	ENOG4108ZE9	Monovalent cation H antiporter subunit C
Tharo_0071	ENOG4107R4Z	monovalent cation h antiporter subunit d
Tharo_0072	ENOG4105SC1	monovalent cation H antiporter subunit E
Tharo_0073	ENOG4105W4C	monovalent cation H antiporter subunit F
Tharo_0074	ENOG4105KJM	monovalent cation h antiporter subunit g
Tharo_0075	ENOG4105DU1	integral membrane protein, terc
Tharo_0078	ENOG4105YAJ	CopG Arc MetJ
Tharo_0080	ENOG4105BZ1	(ABC) transporter
Tharo_0081	ENOG4107RH8	nuclease SbcCD subunit D
Tharo_0087	ENOG4105QPS	Monooxygenase
Tharo_0089	ENOG4105CSU	acyl-Coa dehydrogenase
Tharo_0090	ENOG4105CSU	acyl-Coa dehydrogenase
Tharo_0093	ENOG4105EW9	transcriptional regulator AsnC family
Tharo_0097	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Tharo_0098	ENOG4105DB1	molybdopterin oxidoreductase
Tharo_0099	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
Tharo_0100	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
Tharo_0101	ENOG4105CC9	acyl-Coa dehydrogenase
Tharo_0105	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Tharo_0106	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Tharo_0107	ENOG4107QJE	Chromosome Partitioning Protein
Tharo_0108	ENOG4105FA0	parb-like partition protein
Tharo_0111	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
Tharo_0112	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Tharo_0113	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Tharo_0114	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Tharo_0115	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Tharo_0116	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
Tharo_0117	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Tharo_0118	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Tharo_0121	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Tharo_0123	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Tharo_0124	ENOG4105BZU	Histidine kinase
Tharo_0126	ENOG4105E7A	Glutamine amidotransferase
Tharo_0127	ENOG4105CVR	type I restriction-modification system
Tharo_0133	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Tharo_0134	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Tharo_0135	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Tharo_0136	ENOG4105DFF	Rod shape-determining protein mreb
Tharo_0138	ENOG4105VQ7	Rod shape-determining protein MreD
Tharo_0139	ENOG4105CJN	penicillin-binding protein
Tharo_0140	ENOG4105CNI	cell division protein FtsW
Tharo_0142	ENOG4105DZ1	carboxypeptidase
Tharo_0143	ENOG4105F0I	Aminotransferase
Tharo_0144	ENOG4108Z43	UPF0250 protein
Tharo_0145	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Tharo_0146	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
Tharo_0148	ENOG4105C4R	Atp-dependent dna helicase
Tharo_0165	ENOG4106IPI	cyclase, family
Tharo_0168	ENOG4105F35	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity)
Tharo_0169	ENOG4105DE9	3-keto-5-aminohexanoate cleavage enzyme
Tharo_0173	ENOG4105D25	secreted protein
Tharo_0181	ENOG4108Q52	Methyltransferase cognate corrinoid protein
Tharo_0187	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Tharo_0195	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Tharo_0200	ENOG4105C7K	acetolactate synthase
Tharo_0201	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tharo_0202	ENOG410600T	transposase
Tharo_0215	ENOG4105PPN	plasmid maintenance protein, CcdB
Tharo_0216	ENOG4105DDY	UPF0142 protein ycaO
Tharo_0217	ENOG4105MZG	transcriptional modulator of maze toxin, mazf
Tharo_0218	ENOG4106A2Z	transcriptional regulator antitoxin, MazE
Tharo_0233	ENOG4105CFI	type iii restriction protein res subunit
Tharo_0238	ENOG4108M0I	Transcriptional regulator
Tharo_0241	ENOG4108RXX	maleylacetoacetate isomerase
Tharo_0242	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tharo_0246	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tharo_0252	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Tharo_0253	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Tharo_0254	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Tharo_0256	ENOG4105DVT	helicase
Tharo_0259	ENOG4105BZU	Histidine kinase
Tharo_0260	ENOG4105WH1	Two component transcriptional regulator luxr family
Tharo_0261	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
Tharo_0262	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
Tharo_0263	ENOG41060IM	Heme exporter protein
Tharo_0265	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
Tharo_0266	ENOG4105DA4	cytochrome c-type biogenesis protein
Tharo_0267	ENOG4107QX9	Thiol disulfide interChange protein
Tharo_0268	ENOG4105KWW	Biogenesis protein
Tharo_0269	ENOG4106FI7	cytochrome c-type biogenesis protein
Tharo_0270	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Tharo_0278	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
Tharo_0286	ENOG4105DKK	Benzoate
Tharo_0287	ENOG4105DFA	alanine racemase domain protein
Tharo_0288	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Tharo_0289	ENOG4105C8Y	Acetylornithine aminotransferase
Tharo_0290	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Tharo_0291	ENOG4108KPJ	rna polymerase sigma factor
Tharo_0295	ENOG4107ZSV	Receptor
Tharo_0297	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Tharo_0299	ENOG4106NZI	LysR family Transcriptional regulator
Tharo_0300	ENOG4105W5Q	DNA repair protein (RadC
Tharo_0315	ENOG4105E5H	Transposase
Tharo_0322	ENOG4105DFP	Integrase
Tharo_0324	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Tharo_0325	ENOG41080Z8	PHOSPHOCARRIER protein
Tharo_0326	ENOG4108EQA	pts system
Tharo_0330	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
Tharo_0331	ENOG4108ZC9	flagellar basal-body rod protein flgc
Tharo_0332	ENOG4105W00	Flagellar hook capping protein
Tharo_0333	ENOG4105BZE	flagellar hook protein, FlgE
Tharo_0334	ENOG4108KPB	Flagellar basal-body rod protein FlgF
Tharo_0335	ENOG4105CGA	flagellar basal-body rod protein FlgG
Tharo_0336	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
Tharo_0337	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
Tharo_0338	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
Tharo_0339	ENOG4105E1Q	flagellar hook-associated protein
Tharo_0340	ENOG4105DTJ	flagellar hook-associated protein
Tharo_0341	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
Tharo_0342	ENOG4105VS8	Flagellar biosynthetic protein fliq
Tharo_0343	ENOG4105CN7	Flagellar biosynthetic protein FliP
Tharo_0345	ENOG4105DD5	Flagellar motor switch protein
Tharo_0346	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Tharo_0347	ENOG4107ZI8	flagellar basal body-associated protein flil
Tharo_0351	ENOG4108JIR	Flagellum-specific ATP synthase
Tharo_0353	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Tharo_0354	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
Tharo_0355	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
Tharo_0356	ENOG41063QE	flagellar protein FlaG
Tharo_0357	ENOG4105C8Q	Methyl-accepting chemotaxis
Tharo_0360	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
Tharo_0368	ENOG4105I03	Flagellin
Tharo_0369	ENOG4106R49	Methyltransferase
Tharo_0372	ENOG4105E5H	Transposase
Tharo_0388	ENOG4105DTS	flagellar hook-associated
Tharo_0389	ENOG4105MQ3	flagellar protein FliS
Tharo_0392	ENOG4105VM1	flagellar
Tharo_0393	ENOG4105GEH	Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity)
Tharo_0394	ENOG4106CIA	Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region
Tharo_0395	ENOG4107RD7	Flagellar Motor Protein, MotA
Tharo_0396	ENOG4105ER2	Ompa motb domain protein
Tharo_0397	ENOG4105CBS	Chea signal transduction histidine kinase
Tharo_0398	ENOG4108V3W	Chemotaxis protein, CheW
Tharo_0399	ENOG4105C8Q	Methyl-accepting chemotaxis
Tharo_0400	ENOG4105BZU	Histidine kinase
Tharo_0401	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Tharo_0402	ENOG4108VYJ	response regulator receiver protein
Tharo_0403	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
Tharo_0404	ENOG4105D00	flagellar biosynthetic protein flhB
Tharo_0405	ENOG4105D7B	Flagellar biosynthesis protein flha
Tharo_0406	ENOG4105FZW	flagellar biosynthesis regulator FlhF
Tharo_0409	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tharo_0410	ENOG4105C5H	ABC transporter
Tharo_0412	ENOG4108U78	Glutathione S-transferase
Tharo_0416	ENOG41067CV	Integrase
Tharo_0425	ENOG4105KK6	nuclease
Tharo_0434	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Tharo_0435	ENOG4105K8R	UPF0145 protein
Tharo_0436	ENOG4108IPJ	Membrane
Tharo_0437	ENOG4105CDY	transcriptional regulatory protein
Tharo_0438	ENOG4105D7A	ATP-binding protein
Tharo_0439	ENOG4105SYT	Methylenetetrahydrofolate reductase
Tharo_0440	ENOG4105DX0	Hemolysin A
Tharo_0441	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Tharo_0442	ENOG4105DJ4	phosphatidylserine decarboxylase
Tharo_0443	ENOG4105C8Q	Methyl-accepting chemotaxis
Tharo_0445	ENOG4105C1J	atp-dependent rna helicase
Tharo_0447	ENOG4105D0M	Protease HtpX homolog
Tharo_0449	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
Tharo_0450	ENOG4105EFT	decarboxylase
Tharo_0451	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
Tharo_0452	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tharo_0453	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
Tharo_0454	ENOG4105W2Z	cytochrome C, class I
Tharo_0455	ENOG4105D58	Diguanylate phosphodiesterase
Tharo_0458	ENOG4108YXA	Membrane
Tharo_0459	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
Tharo_0460	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Tharo_0461	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
Tharo_0467	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
Tharo_0468	ENOG4105QAX	Iron-sulfur
Tharo_0471	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Tharo_0472	ENOG4105CZX	twitching motility protein
Tharo_0473	ENOG4105CZX	twitching motility protein
Tharo_0474	ENOG4105DFA	alanine racemase domain protein
Tharo_0475	ENOG4105II7	pyrroline-5-carboxylate reductase
Tharo_0476	ENOG4108VIA	integral membrane protein
Tharo_0478	ENOG4105CD3	dihydroorotase
Tharo_0479	ENOG4105CXT	aspartate transcarbamylase
Tharo_0480	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Tharo_0481	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Tharo_0482	ENOG4108UJU	UPF0301 protein
Tharo_0483	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
Tharo_0484	ENOG4105C87	Aminotransferase class I and II
Tharo_0485	ENOG4105VCQ	rubredoxin
Tharo_0487	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Tharo_0489	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Tharo_0490	ENOG4105CJW	magnesium transporter
Tharo_0491	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
Tharo_0492	ENOG4105E2X	shikimate dehydrogenase
Tharo_0495	ENOG4105IPS	esterase
Tharo_0496	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Tharo_0497	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
Tharo_0498	ENOG4105CQ7	ATP-dependent helicase
Tharo_0500	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
Tharo_0502	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Tharo_0503	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Tharo_0505	ENOG4105CDU	Replicative dna helicase
Tharo_0511	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
Tharo_0512	ENOG4105T95	Thiol disulfide interChange protein
Tharo_0513	ENOG4105CA3	membrane-bound lytic murein transglycosylase
Tharo_0515	ENOG4105M6F	mutator MutT protein
Tharo_0516	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
Tharo_0517	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
Tharo_0518	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Tharo_0520	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Tharo_0521	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Tharo_0523	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tharo_0524	ENOG4105CUX	Signal transduction histidine kinase
Tharo_0526	ENOG4105C5F	glutamine synthetase
Tharo_0529	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Tharo_0530	ENOG4105X23	Endonuclease Exonuclease phosphatase
Tharo_0531	ENOG4105DZQ	phospholipase D Transphosphatidylase
Tharo_0532	ENOG4105K4P	CoA-binding domain protein
Tharo_0533	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
Tharo_0534	ENOG4105MPD	Cytochrome
Tharo_0539	ENOG4108T0W	nitrous oxide maturation protein NosY
Tharo_0540	ENOG4105CIG	ABC transporter
Tharo_0541	ENOG4105DH4	Periplasmic copper-binding protein
Tharo_0543	ENOG4105HEE	Binding Domain protein
Tharo_0547	ENOG4108UYB	regulatoR
Tharo_0548	ENOG4105BZU	Histidine kinase
Tharo_0549	ENOG4105C3G	gtp-binding protein
Tharo_0550	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Tharo_0551	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Tharo_0552	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tharo_0554	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Tharo_0555	ENOG41081V9	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
Tharo_0556	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
Tharo_0557	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
Tharo_0558	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
Tharo_0559	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Tharo_0560	ENOG4106H78	methyltransferase
Tharo_0561	ENOG4105C1V	Peptidase, M16
Tharo_0564	ENOG4105CAK	Cell division ATP-binding protein ftsE
Tharo_0565	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
Tharo_0566	ENOG4105D3R	alkyl hydroperoxide reductase
Tharo_0567	ENOG4108JU3	Alkyl hydroperoxide reductase
Tharo_0568	ENOG4105BZ1	(ABC) transporter
Tharo_0574	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Tharo_0590	ENOG4105D9P	serine threonine protein kinase
Tharo_0592	ENOG4108M24	von Willebrand factor, type A
Tharo_0593	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tharo_0601	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Tharo_0602	ENOG4105C9A	Phoh family
Tharo_0603	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Tharo_0604	ENOG4108JU5	Magnesium and cobalt efflux protein
Tharo_0605	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
Tharo_0606	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
Tharo_0607	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
Tharo_0608	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
Tharo_0609	ENOG4105E9Q	Acyl-transferase
Tharo_0612	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
Tharo_0614	ENOG4105C2X	Arabinose 5-phosphate isomerase
Tharo_0621	ENOG4107QHF	type ii secretion system protein e
Tharo_0623	ENOG4105DHJ	ABC, transporter
Tharo_0624	ENOG4105CY3	ABC transporter, permease
Tharo_0625	ENOG4107PE3	Mammalian cell entry related domain protein
Tharo_0629	ENOG4105DA5	(ABC) transporter
Tharo_0630	ENOG4105E3A	(ABC) transporter
Tharo_0632	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Tharo_0633	ENOG4105NXH	GreA GreB family elongation factor
Tharo_0634	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Tharo_0635	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Tharo_0636	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tharo_0637	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Tharo_0638	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Tharo_0639	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Tharo_0640	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Tharo_0641	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Tharo_0642	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
Tharo_0643	ENOG4105K59	histidine triad (HIT) protein
Tharo_0644	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Tharo_0645	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
Tharo_0646	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Tharo_0647	ENOG4105C0H	protease
Tharo_0648	ENOG4107QNR	UPF0135 protein
Tharo_0651	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Tharo_0652	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Tharo_0653	ENOG4108UW8	fha domain-containing protein
Tharo_0655	ENOG4107QHF	type ii secretion system protein e
Tharo_0656	ENOG4105DJV	ribulose-phosphate 3-epimerase
Tharo_0657	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Tharo_0659	ENOG4105DFP	Integrase
Tharo_0661	ENOG4106NZI	LysR family Transcriptional regulator
Tharo_0662	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
Tharo_0663	ENOG4105CY0	Metallo-Beta-Lactamase
Tharo_0667	ENOG41081QV	Universal stress protein
Tharo_0668	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
Tharo_0669	ENOG4105D6U	Sodium Glutamate Symporter
Tharo_0670	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Tharo_0672	ENOG4107QYA	phosphate
Tharo_0674	ENOG4105CHR	reductase
Tharo_0676	ENOG4105CMI	transporter
Tharo_0677	ENOG4105CJ1	ABC, transporter
Tharo_0678	ENOG4105D0S	secretion protein (HlyD
Tharo_0679	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
Tharo_0688	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
Tharo_0695	ENOG4105W5Q	DNA repair protein (RadC
Tharo_0713	ENOG4107QKA	exodeoxyribonuclease V beta
Tharo_0732	ENOG4105NI8	Cytosine-specific methyltransferase
Tharo_0733	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Tharo_0734	ENOG4107YH6	single-stranded DNA-binding protein
Tharo_0741	ENOG4107QJE	Chromosome Partitioning Protein
Tharo_0744	ENOG4105DDQ	anthranilate synthase
Tharo_0745	ENOG4107QYG	anthranilate phosphoribosyltransferase
Tharo_0746	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Tharo_0748	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
Tharo_0749	ENOG4108V1T	peptidylprolyl cis-trans isomerase
Tharo_0750	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Tharo_0752	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
Tharo_0753	ENOG4105BZ9	Cytochrome C oxidase, subunit I
Tharo_0754	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
Tharo_0756	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
Tharo_0760	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
Tharo_0762	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tharo_0763	ENOG4108Z9W	Outer membrane porin
Tharo_0766	ENOG4108Z9W	Outer membrane porin
Tharo_0773	ENOG4105CHR	reductase
Tharo_0774	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
Tharo_0779	ENOG4105BZU	Histidine kinase
Tharo_0781	ENOG4107R3N	Filamentation induced by cAMP protein fic
Tharo_0782	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
Tharo_0783	ENOG4105C11	sulfate adenylyltransferase), subunit 2
Tharo_0788	ENOG4107TSN	permease
Tharo_0789	ENOG4107R11	Transcriptional regulator
Tharo_0790	ENOG4105HDK	L-asparaginase
Tharo_0792	ENOG4108JJ7	ABC transporter
Tharo_0794	ENOG4107QPN	acyl-Coa dehydrogenase
Tharo_0795	ENOG4105NAU	thioesterase Superfamily protein
Tharo_0797	ENOG4105CHU	acetyl-coa acetyltransferase
Tharo_0799	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
Tharo_0800	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
Tharo_0805	ENOG4105KME	endoribonuclease L-psp
Tharo_0806	ENOG4105CB5	ATP-dependent DNA helicase recG
Tharo_0809	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
Tharo_0814	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
Tharo_0815	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Tharo_0819	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Tharo_0821	ENOG4105XQ6	frataxin-like protein
Tharo_0822	ENOG4108JQC	penicillin-binding protein 1A
Tharo_0827	ENOG4105E4G	Type IV pilus
Tharo_0828	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Tharo_0829	ENOG4105D49	3-dehydroquinate synthase
Tharo_0830	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Tharo_0833	ENOG4108N2Y	auxin Efflux
Tharo_0834	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
Tharo_0835	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Tharo_0837	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Tharo_0838	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Tharo_0841	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
Tharo_0843	ENOG4108Z7G	MaoC domain protein dehydratase
Tharo_0844	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Tharo_0845	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Tharo_0846	ENOG4105BZU	Histidine kinase
Tharo_0848	ENOG4108RU0	short-chain dehydrogenase reductase
Tharo_0849	ENOG4107QPD	alcohol dehydrogenase
Tharo_0856	ENOG4105D2S	major facilitator superfamily
Tharo_0858	ENOG4108JIG	Anaerobic dehydrogenase
Tharo_0861	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
Tharo_0862	ENOG4105C6K	Malic enzyme
Tharo_0863	ENOG41061WM	D-Alanyl-D-Alanine
Tharo_0867	ENOG4108N16	Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region
Tharo_0868	ENOG4105D65	subunit l
Tharo_0869	ENOG4108ZE9	Monovalent cation H antiporter subunit C
Tharo_0870	ENOG4107R4Z	monovalent cation h antiporter subunit d
Tharo_0871	ENOG4105SC1	monovalent cation H antiporter subunit E
Tharo_0872	ENOG4105W4C	monovalent cation H antiporter subunit F
Tharo_0873	ENOG4105KJM	monovalent cation h antiporter subunit g
Tharo_0875	ENOG4105BZU	Histidine kinase
Tharo_0876	ENOG4105FE9	pseudouridine synthase
Tharo_0878	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tharo_0879	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tharo_0880	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tharo_0882	ENOG4106H3A	restriction
Tharo_0885	ENOG4105CX6	glutaminyL-tRNA synthetase
Tharo_0887	ENOG4105CDV	Ompa motb domain protein
Tharo_0888	ENOG4105C0D	helicase
Tharo_0890	ENOG41060A7	DNA polymerase beta domain protein region
Tharo_0891	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Tharo_0892	ENOG4105DWF	phosphomethylpyrimidine kinase
Tharo_0893	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Tharo_0895	ENOG4105DFG	type I secretion outer membrane protein
Tharo_0896	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
Tharo_0897	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
Tharo_0898	ENOG4108Z20	Acyl-transferase
Tharo_0903	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Tharo_0904	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Tharo_0905	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
Tharo_0906	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tharo_0908	ENOG4105DFU	Cell wall formation (By similarity)
Tharo_0910	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Tharo_0911	ENOG41082RQ	UPF0102 protein
Tharo_0912	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Tharo_0913	ENOG4105EKE	dihydroorotase
Tharo_0914	ENOG4105C8Q	Methyl-accepting chemotaxis
Tharo_0915	ENOG4108V6E	Cell division protein mraZ
Tharo_0916	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Tharo_0917	ENOG4106932	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
Tharo_0918	ENOG4105CJN	penicillin-binding protein
Tharo_0919	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Tharo_0920	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
Tharo_0921	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Tharo_0922	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Tharo_0923	ENOG4105CNI	cell division protein FtsW
Tharo_0924	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Tharo_0925	ENOG4105DFU	Cell wall formation (By similarity)
Tharo_0926	ENOG4105CPF	Cell wall formation (By similarity)
Tharo_0927	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
Tharo_0928	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Tharo_0929	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Tharo_0930	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tharo_0936	ENOG4105EY8	ABC transporter
Tharo_0937	ENOG4105E2K	Glycosyl transferase (Group 1
Tharo_0938	ENOG4108DMA	Nad-dependent epimerase dehydratase
Tharo_0939	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
Tharo_0941	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
Tharo_0943	ENOG4108TJN	glycosyl transferase group 1
Tharo_0944	ENOG4108KQJ	Type 11 methyltransferase
Tharo_0946	ENOG4107MQY	Inherit from COG: Hemolysin-type calcium-binding
Tharo_0957	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
Tharo_0959	ENOG4108JJ6	Type I secretion system ATPase
Tharo_0960	ENOG4108JJ6	Type I secretion system ATPase
Tharo_0961	ENOG4107QZV	Type I secretion membrane fusion protein
Tharo_0964	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Tharo_0965	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
Tharo_0966	ENOG4107QTF	adenylosuccinate lyase
Tharo_0968	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tharo_0969	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tharo_0970	ENOG4105VIE	preprotein translocase, subunit YajC
Tharo_0971	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Tharo_0972	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
Tharo_0974	ENOG4105CAF	HipA N-terminal domain protein
Tharo_0976	ENOG41063Z6	transcriptional regulator, lysR family
Tharo_0978	ENOG4108MN8	Membrane
Tharo_0979	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
Tharo_0980	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Tharo_0981	ENOG4108ZXC	Two component transcriptional regulator, luxr family
Tharo_0982	ENOG4105BZU	Histidine kinase
Tharo_0983	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Tharo_0984	ENOG4108RA0	tripartite ATP-independent periplasmic transporter, DctQ component
Tharo_0985	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tharo_0986	ENOG4105DQR	SNARE associated Golgi
Tharo_0987	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Tharo_0988	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Tharo_0991	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Tharo_0992	ENOG4105CUT	histidyl-tRNA synthetase
Tharo_0994	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
Tharo_0995	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Tharo_0996	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
Tharo_0997	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Tharo_0998	ENOG4107QJR	hflk protein
Tharo_0999	ENOG4105EPW	hflc protein
Tharo_1001	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
Tharo_1002	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Tharo_1005	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Tharo_1006	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Tharo_1007	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
Tharo_1008	ENOG4108IFG	nitrite reductase, (NAD(P)H)
Tharo_1013	ENOG4108NVR	Methyl-accepting chemotaxis
Tharo_1014	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Tharo_1015	ENOG4105BZU	Histidine kinase
Tharo_1016	ENOG4105CBS	Chea signal transduction histidine kinase
Tharo_1017	ENOG4108MGY	Histidine kinase
Tharo_1021	ENOG4105BZU	Histidine kinase
Tharo_1023	ENOG4108DBC	nitroreductase
Tharo_1025	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
Tharo_1026	ENOG4107QMP	dna polymerase iii subunits gamma and tau
Tharo_1027	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Tharo_1028	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Tharo_1029	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Tharo_1030	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Tharo_1031	ENOG4105EIX	cytochrome c1
Tharo_1032	ENOG4107MKT	Stringent starvation protein a
Tharo_1033	ENOG4105KB2	stringent starvation protein b
Tharo_1035	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
Tharo_1036	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tharo_1039	ENOG4108RWI	nicotinamidase
Tharo_1040	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Tharo_1042	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Tharo_1044	ENOG4105DAN	ATP-dependent protease
Tharo_1045	ENOG4105E7W	lamb ycsf family protein
Tharo_1046	ENOG4107R7A	Allophanate hydrolase subunit 2
Tharo_1047	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Tharo_1048	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Tharo_1049	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Tharo_1050	ENOG4105DHQ	Histidine kinase
Tharo_1053	ENOG4105K4U	addiction module toxin, RelE StbE family
Tharo_1054	ENOG4105E5M	Multidrug resistance protein D
Tharo_1055	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Tharo_1056	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Tharo_1057	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Tharo_1058	ENOG4105C9M	aspartyl-trna synthetase
Tharo_1063	ENOG4107QHF	type ii secretion system protein e
Tharo_1064	ENOG4108JU6	CBS domain protein
Tharo_1066	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tharo_1071	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tharo_1072	ENOG4105EA8	2-Nitropropane dioxygenase
Tharo_1073	ENOG410624X	efflux transporter, rnd family, mfp subunit
Tharo_1074	ENOG4105BZS	acriflavin resistance protein
Tharo_1076	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Tharo_1079	ENOG4108UM1	dedA family
Tharo_1080	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Tharo_1081	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Tharo_1088	ENOG4105CFH	Aspartokinase
Tharo_1099	ENOG4105KHM	amidohydrolase 2
Tharo_1101	ENOG4105GAK	amidohydrolase 2
Tharo_1105	ENOG4107SET	aldo keto reductase
Tharo_1106	ENOG4105CH5	extracellular solute-binding protein, family 7
Tharo_1109	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tharo_1113	ENOG4105MSY	salicylate hydroxylase
Tharo_1119	ENOG4105CEY	Amp-dependent synthetase and ligase
Tharo_1120	ENOG4105E9F	Enoyl-CoA hydratase
Tharo_1121	ENOG4105CHU	acetyl-coa acetyltransferase
Tharo_1123	ENOG4105CSU	acyl-Coa dehydrogenase
Tharo_1124	ENOG4105CAQ	asparagine synthetase
Tharo_1125	ENOG4108DIG	cyanophycin synthetase
Tharo_1126	ENOG4105DER	m42 family
Tharo_1131	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Tharo_1140	ENOG4105C32	Amino acid ABC transporter (Permease)
Tharo_1141	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Tharo_1142	ENOG4105C0Z	ABC transporter
Tharo_1143	ENOG4108IV0	ABC, transporter
Tharo_1145	ENOG4105VCQ	rubredoxin
Tharo_1146	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Tharo_1148	ENOG4108IEG	Formate dehydrogenase Alpha subunit
Tharo_1149	ENOG4107QP3	malate synthase g
Tharo_1150	ENOG4107SFI	Major Facilitator superfamily
Tharo_1152	ENOG4105C34	Pseudouridine synthase
Tharo_1153	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
Tharo_1155	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
Tharo_1156	ENOG4105CHR	reductase
Tharo_1158	ENOG4108NVM	synthesis repressor PhaR
Tharo_1159	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Tharo_1160	ENOG4105D78	K07001 NTE family protein
Tharo_1161	ENOG4105CQB	FAD linked oxidase domain protein
Tharo_1169	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Tharo_1170	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Tharo_1171	ENOG4105K63	Thioredoxin
Tharo_1172	ENOG4108Z4U	Ferredoxin
Tharo_1174	ENOG4105CEY	Amp-dependent synthetase and ligase
Tharo_1175	ENOG4105C7K	acetolactate synthase
Tharo_1176	ENOG4105M71	acetolactate synthase 1 regulatory subunit
Tharo_1177	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Tharo_1178	ENOG4105D8G	Major Facilitator superfamily
Tharo_1179	ENOG4108K0D	peptidase, M48
Tharo_1180	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tharo_1182	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tharo_1183	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Tharo_1184	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Tharo_1187	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Tharo_1188	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
Tharo_1189	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Tharo_1190	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Tharo_1191	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
Tharo_1192	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Tharo_1195	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
Tharo_1196	ENOG4105C28	cystathionine
Tharo_1197	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
Tharo_1198	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
Tharo_1199	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
Tharo_1200	ENOG4105C8N	cysteinyl-tRNA synthetase
Tharo_1202	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Tharo_1203	ENOG4105CFG	Acts as a chaperone (By similarity)
Tharo_1204	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tharo_1205	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tharo_1208	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tharo_1210	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Tharo_1211	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Tharo_1212	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Tharo_1214	ENOG4105CFV	Tetratricopeptide repeat protein
Tharo_1215	ENOG4105C6T	cysteine synthase
Tharo_1220	ENOG4105Y3U	Transglycosylase-associated protein
Tharo_1222	ENOG4105C22	threonyL-tRNA synthetase
Tharo_1223	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Tharo_1224	ENOG4105VJV	50s ribosomal protein L35
Tharo_1225	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Tharo_1226	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Tharo_1227	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Tharo_1228	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Tharo_1231	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Tharo_1232	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Tharo_1233	ENOG4108K5P	(LipO)protein
Tharo_1234	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tharo_1236	ENOG4105CVE	Lytic murein transglycosylase
Tharo_1238	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Tharo_1239	ENOG4105GJM	(LipO)protein
Tharo_1241	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Tharo_1246	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tharo_1248	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Tharo_1256	ENOG4108UKI	Enoyl-CoA hydratase
Tharo_1259	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
Tharo_1260	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
Tharo_1261	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
Tharo_1262	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
Tharo_1263	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
Tharo_1264	ENOG4107Z3H	Transcriptional regulator, TetR family
Tharo_1266	ENOG4108Z6Z	Transcriptional regulator
Tharo_1267	ENOG4105VDB	UPF0125 protein
Tharo_1268	ENOG4108E8M	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Tharo_1269	ENOG4108UQQ	Electron transport complex
Tharo_1270	ENOG4105D6A	Electron transport complex
Tharo_1271	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Tharo_1272	ENOG4108R3D	Electron transport complex
Tharo_1273	ENOG4105DGN	Electron transport complex
Tharo_1274	ENOG4105S4H	NifU protein
Tharo_1276	ENOG4105CFP	Peptidase U32
Tharo_1278	ENOG4105C26	Dehydrogenase
Tharo_1279	ENOG4105BZU	Histidine kinase
Tharo_1280	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Tharo_1283	ENOG4105J9X	quinohemoprotein amine dehydrogenase gamma subunit
Tharo_1296	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Tharo_1297	ENOG4105DB1	molybdopterin oxidoreductase
Tharo_1298	ENOG4105W87	Cbs domain
Tharo_1300	ENOG4105DQU	oxidoreductase, subunit beta
Tharo_1301	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Tharo_1309	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
Tharo_1312	ENOG4105CHR	reductase
Tharo_1315	ENOG4105C0Z	ABC transporter
Tharo_1316	ENOG4108IV0	ABC, transporter
Tharo_1318	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tharo_1321	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tharo_1322	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
Tharo_1325	ENOG4105C7I	Dehydrogenase
Tharo_1326	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Tharo_1327	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
Tharo_1328	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Tharo_1329	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
Tharo_1330	ENOG4105K4H	Nlp p60 protein
Tharo_1332	ENOG4108Z0R	Transferase
Tharo_1333	ENOG4105D6S	protein involved in catabolism of external DNA
Tharo_1334	ENOG4105CJ3	phosphate transporter
Tharo_1336	ENOG4105EUJ	GTP cyclohydrolase i
Tharo_1338	ENOG4108VWS	Yaeq family
Tharo_1339	ENOG4105BZU	Histidine kinase
Tharo_1340	ENOG4105C1J	atp-dependent rna helicase
Tharo_1341	ENOG4105VEQ	Cold shock protein
Tharo_1342	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
Tharo_1343	ENOG4105DB7	PHP domain protein
Tharo_1344	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
Tharo_1345	ENOG4108Z4T	Peptidase M50
Tharo_1346	ENOG4105C31	Tryptophanyl-tRNA synthetase
Tharo_1347	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
Tharo_1348	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Tharo_1349	ENOG4105FE9	pseudouridine synthase
Tharo_1350	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Tharo_1351	ENOG4105CHV	Transcription elongation factor NusA
Tharo_1352	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Tharo_1353	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Tharo_1354	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Tharo_1355	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Tharo_1356	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Tharo_1357	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tharo_1363	ENOG4105FQT	
Tharo_1370	ENOG4108UNV	SUF system FeS assembly protein, NifU family
Tharo_1371	ENOG4105C9B	Cysteine desulfurase
Tharo_1372	ENOG4105JRK	feS assembly protein SufD
Tharo_1373	ENOG4105C3K	feS assembly ATPase SufC
Tharo_1375	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
Tharo_1380	ENOG4108K3A	Glutathione S-transferase
Tharo_1386	ENOG4105M08	Membrane
Tharo_1390	ENOG4105BZU	Histidine kinase
Tharo_1391	ENOG4105BZU	Histidine kinase
Tharo_1392	ENOG4105DFH	Transport of potassium into the cell (By similarity)
Tharo_1393	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Tharo_1395	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
Tharo_1396	ENOG4105CKW	Inner membrane protein yedI
Tharo_1397	ENOG4105CRK	lysyL-tRNA synthetase
Tharo_1398	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Tharo_1399	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
Tharo_1402	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
Tharo_1405	ENOG4105CZE	histidine utilization repressor
Tharo_1408	ENOG4105DWD	nucleoside recognition domain protein
Tharo_1409	ENOG41088SP	formiminoglutamate hydrolase
Tharo_1410	ENOG4105CI2	imidazolone-5-propionate hydrolase
Tharo_1411	ENOG4107QSN	dihydrolipoamide acetyltransferase
Tharo_1414	ENOG4105EIF	outer membrane protein W
Tharo_1415	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Tharo_1419	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Tharo_1422	ENOG4105C58	cytochrome c oxidase accessory protein ccog
Tharo_1423	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
Tharo_1427	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tharo_1428	ENOG4105C8Y	Acetylornithine aminotransferase
Tharo_1433	ENOG4105CRU	nitrate reductase, alpha subunit
Tharo_1434	ENOG4108IUE	nitrate reductase beta subunit
Tharo_1435	ENOG4105R3A	Nitrate reductase
Tharo_1436	ENOG4105D0D	Nitrate reductase 2, gamma subunit
Tharo_1437	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
Tharo_1439	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Tharo_1440	ENOG4106RZ4	Peptidase U32
Tharo_1441	ENOG4105CFP	Peptidase U32
Tharo_1442	ENOG4108T0W	nitrous oxide maturation protein NosY
Tharo_1443	ENOG4105CIG	ABC transporter
Tharo_1444	ENOG4105DH4	Periplasmic copper-binding protein
Tharo_1446	ENOG4105HEE	Binding Domain protein
Tharo_1448	ENOG4105CCT	upf0313 protein
Tharo_1452	ENOG4105D60	lipoprotein releasing system transmembrane protein
Tharo_1453	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Tharo_1454	ENOG4108EC8	DNA internalization-related competence protein ComEC
Tharo_1457	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
Tharo_1458	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
Tharo_1460	ENOG4105VFB	Binds the 23S rRNA (By similarity)
Tharo_1461	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
Tharo_1462	ENOG4108MIC	Mg-protoporphyrin IX methyl transferase
Tharo_1463	ENOG4106RHG	Yeca family
Tharo_1465	ENOG4105PI0	Ferredoxin
Tharo_1467	ENOG4105WQ3	Rna-binding protein
Tharo_1471	ENOG4107QM5	aconitate hydratase
Tharo_1472	ENOG4107QIJ	Aconitate hydratase 2
Tharo_1473	ENOG4105BZU	Histidine kinase
Tharo_1477	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Tharo_1478	ENOG4105FDP	GntR family transcriptional regulator
Tharo_1482	ENOG4105E33	succinate dehydrogenase
Tharo_1483	ENOG4105Y75	tpr repeat protein
Tharo_1484	ENOG4105BZN	citrate synthase
Tharo_1485	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
Tharo_1486	ENOG4105C7S	Dehydrogenase
Tharo_1487	ENOG4107QN2	dihydrolipoyl dehydrogenase
Tharo_1488	ENOG4105D6Z	AFG1 family ATPase
Tharo_1489	ENOG4105DVT	helicase
Tharo_1490	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
Tharo_1491	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Tharo_1492	ENOG4105M00	molybdopterin converting factor, subunit 1
Tharo_1493	ENOG4108ZAF	Molybdopterin
Tharo_1500	ENOG4108Z6B	deaminase
Tharo_1501	ENOG4108QQZ	ErfK YbiS YcfS YnhG family protein
Tharo_1503	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
Tharo_1504	ENOG4105HHA	aminodeoxychorismate lyase
Tharo_1505	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Tharo_1506	ENOG4107QRG	dna polymerase iii
Tharo_1508	ENOG4105F8V	Hydrolase, tatD family
Tharo_1511	ENOG4105R1U	AraC Family Transcriptional Regulator
Tharo_1512	ENOG4105DJ2	Major Facilitator Superfamily
Tharo_1519	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
Tharo_1520	ENOG4105CH2	amidohydrolase
Tharo_1521	ENOG4105CV6	ABC transporter, permease
Tharo_1524	ENOG4107QJN	gtp cyclohydrolase ii
Tharo_1525	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tharo_1526	ENOG4105DAN	ATP-dependent protease
Tharo_1528	ENOG4108R5S	membrane
Tharo_1530	ENOG4105C4W	S-formylglutathione hydrolase
Tharo_1543	ENOG4107TUY	Histidine kinase
Tharo_1544	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tharo_1547	ENOG4105VG1	fes assembly suf system protein
Tharo_1548	ENOG4105CAS	nag kinase
Tharo_1550	ENOG4105CEY	Amp-dependent synthetase and ligase
Tharo_1552	ENOG4105VN1	Heat shock protein
Tharo_1556	ENOG4105CH7	arginosuccinase
Tharo_1557	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Tharo_1558	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Tharo_1559	ENOG41076E6	Uroporphyrinogen-III Synthase
Tharo_1560	ENOG4105ECF	c-methyltransferase
Tharo_1562	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
Tharo_1563	ENOG4105KWI	UPF0339 protein
Tharo_1564	ENOG4105C12	Phosphoribosylglycinamide synthetase
Tharo_1565	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Tharo_1566	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
Tharo_1567	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Tharo_1568	ENOG4105CHH	sulfate transporter
Tharo_1569	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Tharo_1570	ENOG4105UYK	outer membrane protein a
Tharo_1571	ENOG4105D1F	ATP-binding protein
Tharo_1572	ENOG4105DHP	deoxycytidine triphosphate deaminase
Tharo_1573	ENOG4105CXN	decarboxylase
Tharo_1575	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
Tharo_1590	ENOG4105CGF	Aromatic amino acid aminotransferase
Tharo_1591	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Tharo_1593	ENOG4105C03	ribonuclease
Tharo_1594	ENOG4105EI2	Pseudouridine synthase
Tharo_1596	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Tharo_1597	ENOG4108UHJ	MAF-like protein
Tharo_1598	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
Tharo_1599	ENOG4105VGS	50s ribosomal protein l32
Tharo_1600	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Tharo_1601	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Tharo_1602	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Tharo_1603	ENOG4105CHR	reductase
Tharo_1604	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Tharo_1605	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Tharo_1607	ENOG4108IYU	L-aspartate oxidase
Tharo_1608	ENOG4105EMN	RNA polymerase sigma factor
Tharo_1610	ENOG4105VQK	sigma E regulatory protein, MucB RseB
Tharo_1612	ENOG4105C0H	protease
Tharo_1614	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Tharo_1615	ENOG4105C3F	Signal peptidase i
Tharo_1617	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Tharo_1618	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Tharo_1619	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
Tharo_1620	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
Tharo_1621	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Tharo_1622	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
Tharo_1623	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Tharo_1627	ENOG4105D0M	Protease HtpX homolog
Tharo_1628	ENOG4108V0P	LemA family
Tharo_1629	ENOG4105N5T	Radical SAM Protein
Tharo_1632	ENOG4107QP8	phosphohexose isomerase
Tharo_1633	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Tharo_1640	ENOG4105E09	nadh pyrophosphatase
Tharo_1642	ENOG4107ENK	receptor
Tharo_1652	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
Tharo_1653	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Tharo_1655	ENOG41082UU	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Tharo_1657	ENOG4105NZG	Ferredoxin
Tharo_1658	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Tharo_1659	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
Tharo_1660	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Tharo_1661	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Tharo_1662	ENOG4105DTN	riboflavin biosynthesis protein ribF
Tharo_1663	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Tharo_1664	ENOG4105K8N	protein family UPF0079, ATPase
Tharo_1665	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
Tharo_1666	ENOG41069P5	Protein slyX homolog
Tharo_1667	ENOG4108RH0	Crea protein
Tharo_1668	ENOG4105C0F	tryptophanase EC 4.1.99.1
Tharo_1670	ENOG4105CFP	Peptidase U32
Tharo_1673	ENOG41080IJ	Diacylglycerol kinase
Tharo_1674	ENOG4105EAQ	(twin-arginine translocation) pathway signal
Tharo_1675	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
Tharo_1679	ENOG410812K	response regulator receiver protein
Tharo_1682	ENOG4108IPJ	Membrane
Tharo_1683	ENOG4105C5H	ABC transporter
Tharo_1684	ENOG4105DP0	ferredoxin-NADP reductase
Tharo_1685	ENOG4105DUM	transcriptional regulator, lysR family
Tharo_1686	ENOG4105CJR	Integral membrane protein (MviN
Tharo_1687	ENOG41082GY	Binds directly to 16S ribosomal RNA (By similarity)
Tharo_1689	ENOG4105C8Y	Acetylornithine aminotransferase
Tharo_1690	ENOG4105DBV	ornithine carbamoyltransferase
Tharo_1691	ENOG4105CDH	Citrulline--aspartate ligase
Tharo_1693	ENOG4105NBK	UPF0345 protein
Tharo_1694	ENOG4108VPT	UPF0234 protein
Tharo_1701	ENOG4105P8F	nudix hydrolase
Tharo_1703	ENOG4105CHU	acetyl-coa acetyltransferase
Tharo_1704	ENOG4105E0X	reductase
Tharo_1706	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
Tharo_1708	ENOG4105BZU	Histidine kinase
Tharo_1709	ENOG4107GFK	fumarate
Tharo_1710	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tharo_1712	ENOG4105BZU	Histidine kinase
Tharo_1713	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Tharo_1714	ENOG4108IRC	dna polymerase iii
Tharo_1715	ENOG4107QN1	sodium solute
Tharo_1717	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tharo_1718	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
Tharo_1719	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
Tharo_1722	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tharo_1723	ENOG4105CNG	UPF0061 protein
Tharo_1727	ENOG4105CRU	nitrate reductase, alpha subunit
Tharo_1728	ENOG4108IUE	nitrate reductase beta subunit
Tharo_1729	ENOG4105R3A	Nitrate reductase
Tharo_1730	ENOG4105D0D	Nitrate reductase 2, gamma subunit
Tharo_1731	ENOG4105BZU	Histidine kinase
Tharo_1732	ENOG4105WH1	Two component transcriptional regulator luxr family
Tharo_1735	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Tharo_1737	ENOG4105VDB	UPF0125 protein
Tharo_1738	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Tharo_1739	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Tharo_1740	ENOG4105C0D	helicase
Tharo_1742	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Tharo_1744	ENOG4105CUW	cytochrome C-TYPE protein
Tharo_1747	ENOG4105Y7H	Cytochrome
Tharo_1748	ENOG4106P6N	cytochrome d1 heme region
Tharo_1749	ENOG4108UMR	transcriptional regulator AsnC family
Tharo_1756	ENOG4105FAE	von Willebrand factor, type A
Tharo_1759	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
Tharo_1762	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Tharo_1763	ENOG4105DSQ	Nitric oxide reductase
Tharo_1764	ENOG4108VKQ	nitriC oxide reductase
Tharo_1766	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
Tharo_1767	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
Tharo_1768	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
Tharo_1769	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tharo_1770	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
Tharo_1774	ENOG4105K4H	Nlp p60 protein
Tharo_1777	ENOG4108IAB	Phoh family
Tharo_1778	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tharo_1780	ENOG4105CHM	Aminotransferase
Tharo_1781	ENOG4105D6E	homoserine dehydrogenase
Tharo_1782	ENOG4108RPX	mosc domain containing protein
Tharo_1784	ENOG4105WKW	Pfam:DUF1458
Tharo_1786	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
Tharo_1787	ENOG4107QMS	site-determining protein
Tharo_1788	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Tharo_1789	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
Tharo_1790	ENOG4105KUZ	arsenate reductase
Tharo_1791	ENOG4105BZM	domain protein
Tharo_1793	ENOG4105CD5	CoA-binding domain protein
Tharo_1795	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
Tharo_1797	ENOG4108UJV	acyl-CoA thioesterase i
Tharo_1798	ENOG4108I0Y	(ABC) transporter
Tharo_1799	ENOG4105EAC	phosphoserine phosphatase
Tharo_1800	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
Tharo_1801	ENOG4108R3E	Dna-3-methyladenine glycosylase i
Tharo_1804	ENOG4105DCF	alanine dehydrogenase
Tharo_1806	ENOG4108NWD	Cytochrome
Tharo_1811	ENOG41072AC	4-hydroxybenzoate 3-monooxygenase
Tharo_1814	ENOG4105C32	Amino acid ABC transporter (Permease)
Tharo_1815	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Tharo_1816	ENOG4105C0Z	ABC transporter
Tharo_1817	ENOG4108IV0	ABC, transporter
Tharo_1818	ENOG4105ETT	transcriptional Regulator, LysR family
Tharo_1819	ENOG4105C1G	acyl-Coa dehydrogenase
Tharo_1820	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
Tharo_1821	ENOG4105BZJ	Electron transfer flavoprotein
Tharo_1822	ENOG4105C10	Electron transfer flavoprotein
Tharo_1823	ENOG4105BZU	Histidine kinase
Tharo_1824	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tharo_1827	ENOG4105C32	Amino acid ABC transporter (Permease)
Tharo_1829	ENOG4108IUZ	ABC transporter
Tharo_1830	ENOG4108IV0	ABC, transporter
Tharo_1831	ENOG4105C0A	alcohol dehydrogenase
Tharo_1832	ENOG4105C26	Dehydrogenase
Tharo_1833	ENOG4105C0A	alcohol dehydrogenase
Tharo_1835	ENOG4105D5U	fad dependent oxidoreductase
Tharo_1839	ENOG4105CQZ	Histidine kinase
Tharo_1843	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
Tharo_1844	ENOG4105CVE	Lytic murein transglycosylase
Tharo_1846	ENOG41073TP	transcriptional regulator
Tharo_1850	ENOG4105W1Y	Transcriptional regulator
Tharo_1852	ENOG4105GR3	Histidine kinase
Tharo_1866	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
Tharo_1868	ENOG4105CD5	CoA-binding domain protein
Tharo_1870	ENOG4108ERU	trap dicarboxylate transporter subunit DctP
Tharo_1871	ENOG4105E39	Enoyl-CoA hydratase
Tharo_1873	ENOG4105C1G	acyl-Coa dehydrogenase
Tharo_1874	ENOG4105CHR	reductase
Tharo_1875	ENOG4108UKI	Enoyl-CoA hydratase
Tharo_1876	ENOG4105CHR	reductase
Tharo_1878	ENOG41060WC	Enoyl-CoA hydratase
Tharo_1879	ENOG4108R86	Transcriptional regulator
Tharo_1880	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Tharo_1881	ENOG4105UYK	outer membrane protein a
Tharo_1882	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Tharo_1883	ENOG4105D9P	serine threonine protein kinase
Tharo_1884	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
Tharo_1885	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Tharo_1886	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Tharo_1887	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Tharo_1888	ENOG41090R7	Ferric uptake
Tharo_1889	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
Tharo_1890	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Tharo_1891	ENOG4105BZU	Histidine kinase
Tharo_1892	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Tharo_1893	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Tharo_1894	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Tharo_1895	ENOG4105HBR	Rna-binding protein
Tharo_1896	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
Tharo_1897	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Tharo_1898	ENOG4105EEI	dihydropteroate synthase
Tharo_1899	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Tharo_1901	ENOG4105C8U	phosphate abc transporter
Tharo_1903	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Tharo_1906	ENOG4105D6J	arsenicaL-resistance protein
Tharo_1909	ENOG4108UXE	Protein tyrosine phosphatase
Tharo_1911	ENOG4105CP7	Triose-phosphate isomerase
Tharo_1912	ENOG4107EJC	Preprotein translocase subunit SecG
Tharo_1914	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tharo_1915	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tharo_1916	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tharo_1917	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tharo_1919	ENOG4107QIZ	NADH dehydrogenase
Tharo_1920	ENOG4108IEH	NADH dehydrogenase subunit g
Tharo_1921	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Tharo_1922	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tharo_1923	ENOG4105DF2	NADH dehydrogenase subunit j
Tharo_1924	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tharo_1925	ENOG4105D65	subunit l
Tharo_1926	ENOG4105C8S	subunit m
Tharo_1927	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tharo_1928	ENOG4108YZ4	nudix hydrolase
Tharo_1929	ENOG4105C4K	Nad synthetase
Tharo_1930	ENOG4108YZA	Nitrogen regulatory protein pii
Tharo_1931	ENOG4108DG9	Smr protein MutS2
Tharo_1932	ENOG4105C3M	thioredoxin reductase
Tharo_1933	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
Tharo_1934	ENOG4105CNU	cell division protein FtsK
Tharo_1935	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
Tharo_1936	ENOG4105D1H	recombination factor protein RarA
Tharo_1938	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Tharo_1939	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
Tharo_1947	ENOG4105BZU	Histidine kinase
Tharo_1948	ENOG4108JA2	transcriptioN-repair coupling factor
Tharo_1950	ENOG4105NBF	ammecr1 domain protein
Tharo_1951	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
Tharo_1952	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Tharo_1953	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Tharo_1957	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Tharo_1958	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
Tharo_1959	ENOG4105C9X	ppx gppa phosphatase
Tharo_1961	ENOG4105DHJ	ABC, transporter
Tharo_1964	ENOG4105CEY	Amp-dependent synthetase and ligase
Tharo_1966	ENOG4105EYA	deoxyribonuclease
Tharo_1968	ENOG4105CSU	acyl-Coa dehydrogenase
Tharo_1969	ENOG4107TF3	peptidylprolyl cis-trans isomerase
Tharo_1971	ENOG4105K9H	YciI-like protein
Tharo_1972	ENOG4107835	probably involved in intracellular septation (By similarity)
Tharo_1973	ENOG4105E0F	Histidine kinase
Tharo_1974	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Tharo_1976	ENOG41072GX	Peptidase M22 Glycoprotease
Tharo_1977	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
Tharo_1978	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Tharo_1979	ENOG4108J8Q	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity)
Tharo_1980	ENOG4105DUM	transcriptional regulator, lysR family
Tharo_1981	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Tharo_1989	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
Tharo_1990	ENOG4105IPI	Membrane
Tharo_1991	ENOG41062QD	Membrane
Tharo_1992	ENOG4107QN1	sodium solute
Tharo_1993	ENOG41062D9	Histidine kinase
Tharo_1995	ENOG4107PU6	Membrane
Tharo_1996	ENOG4107QSN	dihydrolipoamide acetyltransferase
Tharo_1997	ENOG4105D2S	major facilitator superfamily
Tharo_1999	ENOG4108Q52	Methyltransferase cognate corrinoid protein
Tharo_2000	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Tharo_2011	ENOG4105E6M	Sulphatase-modifying factor protein
Tharo_2012	ENOG4107T8Q	Glycosyl transferase (Group 1
Tharo_2013	ENOG4107T9Q	phosphonate abc transporter
Tharo_2014	ENOG4105D5T	phosphonate abc transporter
Tharo_2015	ENOG4105S7S	phosphonate abc transporter
Tharo_2025	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
Tharo_2029	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tharo_2030	ENOG4105FE1	phytoene synthase
Tharo_2032	ENOG4107S11	squalene-associated FAD-dependent desaturase
Tharo_2033	ENOG4105C4R	Atp-dependent dna helicase
Tharo_2035	ENOG4105D1Q	UPF0246 protein
Tharo_2038	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
Tharo_2039	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
Tharo_2040	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
Tharo_2041	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
Tharo_2047	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
Tharo_2053	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Tharo_2054	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tharo_2055	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tharo_2056	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Tharo_2057	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tharo_2059	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tharo_2061	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Tharo_2062	ENOG4105KNE	Phosphatidate cytidylyltransferase
Tharo_2063	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Tharo_2064	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Tharo_2065	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Tharo_2066	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Tharo_2067	ENOG4105CE9	30S ribosomal protein S2
Tharo_2068	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
Tharo_2069	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
Tharo_2070	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
Tharo_2072	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Tharo_2073	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Tharo_2075	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Tharo_2076	ENOG4105CHM	Aminotransferase
Tharo_2077	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
Tharo_2078	ENOG4105CZX	twitching motility protein
Tharo_2079	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Tharo_2081	ENOG4105WVQ	Fe-S assembly protein IscX
Tharo_2082	ENOG4108ZIT	Ferredoxin, 2FE-2S
Tharo_2083	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
Tharo_2084	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
Tharo_2085	ENOG4108Z4V	iron-sulfur cluster assembly
Tharo_2086	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
Tharo_2087	ENOG4105C3J	Cysteine desulfurase
Tharo_2088	ENOG4105C3J	Cysteine desulfurase
Tharo_2089	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
Tharo_2090	ENOG4105D7W	serine acetyltransferase
Tharo_2092	ENOG4105ECY	inositol monophosphatase
Tharo_2106	ENOG4105KUS	lysozyme
Tharo_2123	ENOG4108TFU	terminase (Small subunit)
Tharo_2129	ENOG4105XB7	anti-repressor protein
Tharo_2144	ENOG4105DH7	May be involved in recombination (By similarity)
Tharo_2145	ENOG4107WZZ	SMC domain protein
Tharo_2160	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Tharo_2163	ENOG4105W87	Cbs domain
Tharo_2164	ENOG4107RZZ	dna polymerase iii epsilon subunit
Tharo_2165	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Tharo_2166	ENOG4105D1A	Methyltransferase
Tharo_2167	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Tharo_2168	ENOG4105E9H	Lytic Murein transglycosylase
Tharo_2170	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Tharo_2172	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Tharo_2175	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tharo_2184	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
Tharo_2185	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Tharo_2186	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tharo_2190	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Tharo_2191	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
Tharo_2192	ENOG4105W49	UPF0434 protein
Tharo_2193	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
Tharo_2194	ENOG4109015	Biopolymer transport protein exbD tolR
Tharo_2196	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Tharo_2197	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Tharo_2198	ENOG4105DR9	pseudouridine synthase
Tharo_2199	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tharo_2202	ENOG4108R3D	Electron transport complex
Tharo_2203	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Tharo_2207	ENOG4105CSM	endonuclease III
Tharo_2210	ENOG410829K	Lysine exporter protein (Lyse ygga)
Tharo_2212	ENOG4105D03	DNA-3-methyladenine glycosylase II
Tharo_2213	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Tharo_2214	ENOG4105EVD	ribosomal RNA large subunit methyltransferase N
Tharo_2215	ENOG4106RE7	Cytochrome
Tharo_2216	ENOG4105N7H	Cytochrome
Tharo_2217	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Tharo_2224	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
Tharo_2225	ENOG4108RRZ	Transcription elongation factor GreB
Tharo_2227	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
Tharo_2231	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
Tharo_2235	ENOG4105GVR	general secretion pathway protein D
Tharo_2240	ENOG41069G9	General secretion pathway protein J
Tharo_2243	ENOG4108VAU	general secretion pathway protein G
Tharo_2244	ENOG4105D7Q	type ii secretion system
Tharo_2245	ENOG4107QHF	type ii secretion system protein e
Tharo_2249	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
Tharo_2250	ENOG4105BZU	Histidine kinase
Tharo_2251	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
Tharo_2252	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
Tharo_2253	ENOG4105BZU	Histidine kinase
Tharo_2254	ENOG4108ZXC	Two component transcriptional regulator, luxr family
Tharo_2255	ENOG4105DB1	molybdopterin oxidoreductase
Tharo_2256	ENOG4106WHD	Tetrathionate reductase
Tharo_2257	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Tharo_2258	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Tharo_2262	ENOG4107RQ2	Cytochrome c oxidase, subunit I
Tharo_2264	ENOG41090A4	Pterin carbinolamine dehydratase
Tharo_2265	ENOG4107QUY	Guanine deaminase
Tharo_2266	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Tharo_2267	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
Tharo_2268	ENOG4105BZU	Histidine kinase
Tharo_2269	ENOG4108V3W	Chemotaxis protein, CheW
Tharo_2270	ENOG4105C8Q	Methyl-accepting chemotaxis
Tharo_2271	ENOG4105CBS	Chea signal transduction histidine kinase
Tharo_2273	ENOG4108VYJ	response regulator receiver protein
Tharo_2274	ENOG4108W2P	Methyl-accepting chemotaxis
Tharo_2275	ENOG4105BZU	Histidine kinase
Tharo_2276	ENOG4105BZU	Histidine kinase
Tharo_2278	ENOG4105BZU	Histidine kinase
Tharo_2279	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
Tharo_2280	ENOG4105F0N	pyrophosphate phospho-hydrolase
Tharo_2282	ENOG4105C59	p-type ATPase
Tharo_2286	ENOG4105D4P	Coproporphyrinogen iii oxidase
Tharo_2287	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
Tharo_2288	ENOG4108YY7	Invasion gene expression up-regulator SirB
Tharo_2289	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
Tharo_2290	ENOG4105CY0	Metallo-Beta-Lactamase
Tharo_2295	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
Tharo_2298	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
Tharo_2300	ENOG4105C59	p-type ATPase
Tharo_2304	ENOG41067MG	lrgb family
Tharo_2309	ENOG4107QN1	sodium solute
Tharo_2311	ENOG4105E9K	Isocitrate dehydrogenase
Tharo_2312	ENOG4108RJ7	Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity)
Tharo_2313	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Tharo_2314	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Tharo_2315	ENOG4105W5Q	DNA repair protein (RadC
Tharo_2316	ENOG4105KDC	50s ribosomal protein l28
Tharo_2317	ENOG4105W0E	50S ribosomal protein L33
Tharo_2318	ENOG4105VEQ	Cold shock protein
Tharo_2319	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
Tharo_2320	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tharo_2321	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
Tharo_2322	ENOG4108I9X	Isocitrate lyase
Tharo_2324	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Tharo_2325	ENOG4105E0F	Histidine kinase
Tharo_2328	ENOG4105KHC	sulfurtransferase
Tharo_2329	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
Tharo_2330	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Tharo_2331	ENOG4105DR5	peptidase
Tharo_2332	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
Tharo_2333	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Tharo_2334	ENOG4108UJD	30S ribosomal protein S9
Tharo_2335	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Tharo_2336	ENOG4108UKZ	OsmC family
Tharo_2337	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
Tharo_2340	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Tharo_2341	ENOG4108RAC	Rubrerythrin
Tharo_2342	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Tharo_2343	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Tharo_2344	ENOG4105E4C	Lytic transglycosylase catalytic
Tharo_2346	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tharo_2348	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Tharo_2351	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
Tharo_2356	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Tharo_2359	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Tharo_2361	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
Tharo_2365	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Tharo_2368	ENOG4108WBT	adenosyltransferase
Tharo_2369	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Tharo_2370	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
Tharo_2371	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
Tharo_2372	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
Tharo_2374	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Tharo_2375	ENOG4105N42	UPF0307 protein
Tharo_2376	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
Tharo_2377	ENOG4105CH5	extracellular solute-binding protein, family 7
Tharo_2379	ENOG4105CH5	extracellular solute-binding protein, family 7
Tharo_2381	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tharo_2382	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Tharo_2383	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Tharo_2384	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Tharo_2385	ENOG4105D06	uba thif-type nad fad binding protein
Tharo_2387	ENOG4105CN1	protease
Tharo_2389	ENOG41080HT	Transcriptional regulator, arsr family
Tharo_2390	ENOG41082J7	Rhodanese domain protein
Tharo_2391	ENOG4105VW4	glutaredoxin 3
Tharo_2392	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
Tharo_2394	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Tharo_2395	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
Tharo_2396	ENOG4105MJ2	Competence protein
Tharo_2397	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
Tharo_2398	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
Tharo_2400	ENOG4105D52	delta-aminolevulinic acid dehydratase
Tharo_2401	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Tharo_2402	ENOG4106RE7	Cytochrome
Tharo_2403	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Tharo_2404	ENOG4105E66	phosphoriboisomerase A
Tharo_2405	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Tharo_2406	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
Tharo_2407	ENOG4108EKC	n-acetylglutamate synthase
Tharo_2408	ENOG4105CSR	polyphosphate kinase 2
Tharo_2409	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
Tharo_2410	ENOG4105ECY	inositol monophosphatase
Tharo_2411	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
Tharo_2413	ENOG4107SJW	iron permease, FTR1
Tharo_2417	ENOG4105GR3	Histidine kinase
Tharo_2418	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Tharo_2420	ENOG4105UTB	Blue (Type 1) copper domain protein
Tharo_2423	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
Tharo_2424	ENOG4108IJF	Heavy metal efflux pump, CzcA
Tharo_2428	ENOG4105CV1	Transketolase (EC 2.2.1.1)
Tharo_2429	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Tharo_2430	ENOG4105BZA	Phosphoglycerate kinase
Tharo_2431	ENOG4105CA9	Pyruvate kinase
Tharo_2433	ENOG4108JIG	Anaerobic dehydrogenase
Tharo_2435	ENOG4105DSY	exodeoxyribonuclease V, gamma
Tharo_2436	ENOG4107QKA	exodeoxyribonuclease V beta
Tharo_2437	ENOG4107QYX	exodeoxyribonuclease v alpha
Tharo_2438	ENOG4105C8V	SAICAR synthetase
Tharo_2441	ENOG4105DGW	oligopeptidase A
Tharo_2442	ENOG4105BZU	Histidine kinase
Tharo_2443	ENOG4108W2P	Methyl-accepting chemotaxis
Tharo_2447	ENOG4105D0A	hydroxylase
Tharo_2448	ENOG4107RAQ	aminopeptidase
Tharo_2449	ENOG4108S0S	Nucleotidyl transferase
Tharo_2450	ENOG4105EHM	Aminoglycoside phosphotransferase
Tharo_2451	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
Tharo_2452	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
Tharo_2453	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
Tharo_2454	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Tharo_2455	ENOG4105C0B	DNA polymerase III (alpha subunit)
Tharo_2456	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
Tharo_2457	ENOG4105HDD	phospholipase
Tharo_2458	ENOG4105C6K	Malic enzyme
Tharo_2463	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
Tharo_2465	ENOG41086KC	Transcriptional regulator
Tharo_2467	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
Tharo_2469	ENOG4105C4R	Atp-dependent dna helicase
Tharo_2472	ENOG4105C8T	Leucyl-tRNA synthetase
Tharo_2474	ENOG4105DJF	DNA polymerase III, delta' subunit
Tharo_2475	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Tharo_2477	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Tharo_2478	ENOG4108Z66	YbaK ebsC protein
Tharo_2481	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Tharo_2482	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tharo_2483	ENOG4105VCC	30S ribosomal protein S21
Tharo_2485	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tharo_2487	ENOG4107R3N	Filamentation induced by cAMP protein fic
Tharo_2489	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Tharo_2490	ENOG4105C02	permease
Tharo_2491	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
Tharo_2493	ENOG4105DJ0	Poly(A) Polymerase
Tharo_2494	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tharo_2496	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Tharo_2497	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
Tharo_2498	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Tharo_2499	ENOG4105CD8	aminopeptidase N
Tharo_2501	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
Tharo_2504	ENOG4105C7K	acetolactate synthase
Tharo_2505	ENOG4108ZP8	Acetolactate synthase small subunit
Tharo_2506	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Tharo_2507	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
Tharo_2508	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Tharo_2510	ENOG4105CS1	NAD(P)H quinone oxidoreductase
Tharo_2511	ENOG4105K5M	30s ribosomal protein S16
Tharo_2512	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Tharo_2513	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Tharo_2514	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Tharo_2515	ENOG4108K5H	permease YjgP YjgQ family protein
Tharo_2516	ENOG4108M8S	permease YjgP YjgQ family protein
Tharo_2517	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Tharo_2520	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Tharo_2521	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
Tharo_2522	ENOG4105ERG	peptidase m48, ste24p
Tharo_2523	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tharo_2524	ENOG4105BZU	Histidine kinase
Tharo_2525	ENOG4105BZU	Histidine kinase
Tharo_2526	ENOG4105BZU	Histidine kinase
Tharo_2527	ENOG4108T5I	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Tharo_2529	ENOG4108VYJ	response regulator receiver protein
Tharo_2532	ENOG4105C8Q	Methyl-accepting chemotaxis
Tharo_2533	ENOG4105CBS	Chea signal transduction histidine kinase
Tharo_2537	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Tharo_2539	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
Tharo_2540	ENOG4105DRR	Transcriptional regulator, GntR family
Tharo_2541	ENOG4105CHU	acetyl-coa acetyltransferase
Tharo_2545	ENOG4105C1G	acyl-Coa dehydrogenase
Tharo_2546	ENOG4105D5P	Methylmalonyl-coA mutase
Tharo_2551	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
Tharo_2554	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Tharo_2555	ENOG4107XAN	XdhC and CoxI family
Tharo_2562	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Tharo_2563	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Tharo_2565	ENOG4105DS1	cytochrome b561
Tharo_2567	ENOG4108YYC	ycei family
Tharo_2568	ENOG4105CHF	Glutathione S-transferase
Tharo_2571	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
Tharo_2573	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
Tharo_2574	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
Tharo_2575	ENOG4105CKK	Glycosyl transferase, family 2
Tharo_2579	ENOG4105EAH	synthase
Tharo_2580	ENOG4105BZ7	extracellular solute-binding protein family 1
Tharo_2581	ENOG4105CPC	Aldo Keto reductase
Tharo_2582	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
Tharo_2583	ENOG4105C1J	atp-dependent rna helicase
Tharo_2584	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Tharo_2585	ENOG4105W8H	transhydrogenase (subunit alpha
Tharo_2586	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Tharo_2587	ENOG4108ZF3	Phosphatase
Tharo_2588	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Tharo_2589	ENOG4105EU8	FAD linked oxidase domain protein
Tharo_2591	ENOG4105CQB	FAD linked oxidase domain protein
Tharo_2592	ENOG4105W8I	Transcriptional regulator
Tharo_2593	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Tharo_2594	ENOG4105K46	50S ribosomal protein l27
Tharo_2595	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tharo_2596	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Tharo_2597	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tharo_2598	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
Tharo_2599	ENOG4105C5H	ABC transporter
Tharo_2604	ENOG41082AG	Plasmid maintenance system antidote protein
Tharo_2606	ENOG4108YZN	class I peptide chain release factor
Tharo_2608	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
Tharo_2610	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
Tharo_2611	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Tharo_2620	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tharo_2621	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
Tharo_2622	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Tharo_2623	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Tharo_2625	ENOG4108ZXC	Two component transcriptional regulator, luxr family
Tharo_2626	ENOG4105BZU	Histidine kinase
Tharo_2628	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
Tharo_2629	ENOG4107QSN	dihydrolipoamide acetyltransferase
Tharo_2630	ENOG4107QN2	dihydrolipoyl dehydrogenase
Tharo_2634	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Tharo_2659	ENOG4105K70	DNA-binding protein
Tharo_2660	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Tharo_2661	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Tharo_2662	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Tharo_2663	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Tharo_2664	ENOG4105CYN	Serine protein kinase
Tharo_2665	ENOG4106AKX	UPF0229 protein
Tharo_2666	ENOG4105ED1	spovr family
Tharo_2667	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Tharo_2669	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Tharo_2671	ENOG4105J5G	Transferase hexapeptide repeat containing protein
Tharo_2675	ENOG4105CHM	Aminotransferase
Tharo_2676	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Tharo_2679	ENOG4105R48	this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase
Tharo_2681	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
Tharo_2682	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
Tharo_2683	ENOG4108MTB	glycosyl transferase family
Tharo_2684	ENOG4105EUB	pirin domain protein
Tharo_2685	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
Tharo_2687	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
Tharo_2692	ENOG4105CUZ	uba thif-type nad fad binding protein
Tharo_2695	ENOG4107RDB	Major Facilitator
Tharo_2696	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Tharo_2697	ENOG4105CMR	udp-glucose 4-epimerase
Tharo_2698	ENOG4108ZT0	50S ribosomal protein l17
Tharo_2699	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tharo_2700	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Tharo_2701	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Tharo_2702	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tharo_2703	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Tharo_2704	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Tharo_2705	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Tharo_2706	ENOG4105VPB	50S ribosomal protein L30
Tharo_2707	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Tharo_2708	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Tharo_2709	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Tharo_2710	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Tharo_2711	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Tharo_2712	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tharo_2713	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Tharo_2714	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Tharo_2715	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Tharo_2716	ENOG41083MP	50s ribosomal protein l29
Tharo_2717	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Tharo_2718	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Tharo_2719	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Tharo_2720	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Tharo_2721	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tharo_2722	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Tharo_2723	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Tharo_2724	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Tharo_2725	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Tharo_2726	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Tharo_2727	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Tharo_2728	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Tharo_2729	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Tharo_2730	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tharo_2731	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tharo_2732	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Tharo_2733	ENOG4108VZM	50s ribosomal protein L10
Tharo_2734	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Tharo_2735	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Tharo_2737	ENOG4105PM1	preprotein translocase subunit SecE
Tharo_2739	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Tharo_2743	ENOG4105CQB	FAD linked oxidase domain protein
Tharo_2744	ENOG4105WH1	Two component transcriptional regulator luxr family
Tharo_2746	ENOG4105BZU	Histidine kinase
Tharo_2752	ENOG4107U53	septum site-determining protein minD
Tharo_2763	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Tharo_2766	ENOG4108ZXC	Two component transcriptional regulator, luxr family
Tharo_2769	ENOG4106VK6	Flagellar motor protein
Tharo_2771	ENOG4105D5P	Methylmalonyl-coA mutase
Tharo_2775	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Tharo_2776	ENOG41080XP	Cbs domain
Tharo_2779	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Tharo_2781	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Tharo_2786	ENOG4105DZS	Phenylacetate-CoA ligase
Tharo_2789	ENOG4105CGZ	zinc metallopeptidase
Tharo_2790	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
Tharo_2792	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Tharo_2793	ENOG4107QX3	carboxylase
Tharo_2794	ENOG4105DJT	lAO AO transport system ATPase
Tharo_2795	ENOG4105D5P	Methylmalonyl-coA mutase
Tharo_2796	ENOG4105DRR	Transcriptional regulator, GntR family
Tharo_2797	ENOG4105C37	(CBS) domain
Tharo_2801	ENOG4105BZU	Histidine kinase
Tharo_2804	ENOG4108Q9V	regulatoR
Tharo_2806	ENOG4108JJA	ABC, transporter
Tharo_2809	ENOG4107R39	(ABC) transporter
Tharo_2810	ENOG4105MYN	Zinc uptake regulation protein
Tharo_2812	ENOG4105E0A	ABC, transporter
Tharo_2813	ENOG4105CC5	ABC transporter
Tharo_2815	ENOG4105HF0	Membrane
Tharo_2818	ENOG4105C08	Histidine kinase
Tharo_2819	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
Tharo_2820	ENOG4105WH1	Two component transcriptional regulator luxr family
Tharo_2822	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
Tharo_2824	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Tharo_2827	ENOG4105C01	Dihydroxy-acid dehydratase
Tharo_2828	ENOG4108YXG	UPF0502 protein
Tharo_2829	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Tharo_2831	ENOG4105BZU	Histidine kinase
Tharo_2836	ENOG4108UQY	Iron-storage protein
Tharo_2839	ENOG4105SG9	biopolymer transport protein, ExbD
Tharo_2842	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tharo_2843	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
Tharo_2844	ENOG4105GAV	receptor
Tharo_2848	ENOG4105E0K	tonB-dependent siderophore receptor
Tharo_2856	ENOG4105C59	p-type ATPase
Tharo_2862	ENOG4107QX8	SPFH domain, Band 7 family protein
Tharo_2865	ENOG4105BZU	Histidine kinase
Tharo_2872	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
Tharo_2873	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
Tharo_2874	ENOG4107YD3	Thioesterase
Tharo_2875	ENOG4105E02	MotA TolQ exbB proton channel
Tharo_2876	ENOG4108ZZF	transport protein (ExbD)
Tharo_2878	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
Tharo_2879	ENOG4105KCK	Peptidoglycan-associated lipoprotein
Tharo_2881	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
Tharo_2882	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
Tharo_2897	ENOG41067CV	Integrase
Tharo_2898	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Tharo_2899	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
Tharo_2902	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Tharo_2904	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tharo_2910	ENOG4105D25	secreted protein
Tharo_2916	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tharo_2917	ENOG4105EQN	UPF0261 protein
Tharo_2918	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
Tharo_2919	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Tharo_2920	ENOG4107QSA	Oxaloacetate decarboxylase
Tharo_2925	ENOG4105CHU	acetyl-coa acetyltransferase
Tharo_2927	ENOG4105CB2	alcohol dehydrogenase
Tharo_2931	ENOG4105J8Z	peptidase S8 and S53, subtilisin, kexin, sedolisin
Tharo_2932	ENOG4105BZ1	(ABC) transporter
Tharo_2933	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Tharo_2936	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
Tharo_2937	ENOG4108JGH	Tetr family transcriptional regulator
Tharo_2938	ENOG410846T	CoA-transferase family III
Tharo_2939	ENOG4105DTQ	mandelate racemase muconate lactonizing
Tharo_2942	ENOG4105RD8	TRAP dicarboxylate transporter
Tharo_2943	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
Tharo_2945	ENOG41060WC	Enoyl-CoA hydratase
Tharo_2946	ENOG4107QX3	carboxylase
Tharo_2947	ENOG4105CHU	acetyl-coa acetyltransferase
Tharo_2948	ENOG4105C1G	acyl-Coa dehydrogenase
Tharo_2950	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
Tharo_2956	ENOG4105C75	arginyL-tRNA synthetase
Tharo_2957	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
Tharo_2958	ENOG4105C8Y	Acetylornithine aminotransferase
Tharo_2960	ENOG4105CFP	Peptidase U32
Tharo_2961	ENOG4106RZ4	Peptidase U32
Tharo_2962	ENOG4105XPQ	lipid carrier protein
Tharo_2963	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
Tharo_2964	ENOG4108ZAI	phosphatidylglycerophosphatase a
Tharo_2965	ENOG4107TH8	cina domain protein
Tharo_2966	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Tharo_2967	ENOG4108004	Modulates RecA activity (By similarity)
Tharo_2968	ENOG4108IUZ	ABC transporter
Tharo_2969	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tharo_2970	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
Tharo_2971	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
Tharo_2972	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
Tharo_2973	ENOG4105C7B	Threonine dehydratase
Tharo_2974	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
Tharo_2975	ENOG4107SC1	transglycosylase
Tharo_2976	ENOG4105CGD	Nad-dependent epimerase dehydratase
Tharo_2978	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Tharo_2979	ENOG4105CYM	Glutathione S-transferase
Tharo_2980	ENOG410832A	alpha/beta hydrolase fold
Tharo_2981	ENOG4105C8Q	Methyl-accepting chemotaxis
Tharo_2983	ENOG4105CHR	reductase
Tharo_2984	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Tharo_2986	ENOG4105W39	Membrane
Tharo_2988	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Tharo_2990	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Tharo_2991	ENOG4105CGK	Exodeoxyribonuclease III
Tharo_2992	ENOG4105BZU	Histidine kinase
Tharo_2993	ENOG4105BZU	Histidine kinase
Tharo_2994	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Tharo_2996	ENOG4105C2C	drug resistance transporter, Bcr CflA
Tharo_2997	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Tharo_2999	ENOG4107R13	MMPL domain protein
Tharo_3001	ENOG4105D25	secreted protein
Tharo_3005	ENOG4108K3Z	AraC family transcriptional regulator
Tharo_3012	ENOG4105BZU	Histidine kinase
Tharo_3013	ENOG4105BZU	Histidine kinase
Tharo_3019	ENOG4105FB9	CRISPR-associated protein
Tharo_3023	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
Tharo_3024	ENOG4105KCF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
Tharo_3030	ENOG4105BZU	Histidine kinase
Tharo_3031	ENOG4107RES	phosphoglycerol transferase I
Tharo_3032	ENOG4105CD5	CoA-binding domain protein
Tharo_3033	ENOG4105E39	Enoyl-CoA hydratase
Tharo_3035	ENOG4105BZU	Histidine kinase
Tharo_3036	ENOG4105D4A	Cell wall formation (By similarity)
Tharo_3040	ENOG4105DUM	transcriptional regulator, lysR family
Tharo_3045	ENOG4105C31	Tryptophanyl-tRNA synthetase
Tharo_3049	ENOG4105D64	Mechanosensitive ion channel
Tharo_3050	ENOG4105BZU	Histidine kinase
Tharo_3051	ENOG4105BZU	Histidine kinase
Tharo_3053	ENOG4105EHZ	conserved protein UCP016719
Tharo_3054	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tharo_3055	ENOG4108UVJ	appr-1-p processing domain protein
Tharo_3056	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Tharo_3057	ENOG4105W8H	transhydrogenase (subunit alpha
Tharo_3058	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Tharo_3059	ENOG4105C10	Electron transfer flavoprotein
Tharo_3060	ENOG4105BZJ	Electron transfer flavoprotein
Tharo_3064	ENOG4105D25	secreted protein
Tharo_3075	ENOG4105C2C	drug resistance transporter, Bcr CflA
Tharo_3081	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
Tharo_3082	ENOG4108V1U	phospholipid-binding protein
Tharo_3087	ENOG4105CHR	reductase
Tharo_3088	ENOG4105CHR	reductase
Tharo_3091	ENOG4105FFC	UPF0187 protein
Tharo_3092	ENOG4105C3R	Methionine synthase
Tharo_3095	ENOG4105CP9	extracellular ligand-binding receptor
Tharo_3097	ENOG4105C32	Amino acid ABC transporter (Permease)
Tharo_3098	ENOG4108IV0	ABC, transporter
Tharo_3099	ENOG4105C0Z	ABC transporter
Tharo_3100	ENOG4105C2C	drug resistance transporter, Bcr CflA
Tharo_3101	ENOG4105C0P	Mg chelatase subunit ChlI
Tharo_3104	ENOG4108YZA	Nitrogen regulatory protein pii
Tharo_3105	ENOG4105BZU	Histidine kinase
Tharo_3111	ENOG4105ECA	phosphoserine phosphatase homoserine phosphotransferase bifunctional protein
Tharo_3116	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tharo_3117	ENOG4105BZU	Histidine kinase
Tharo_3118	ENOG4105EMN	RNA polymerase sigma factor
Tharo_3119	ENOG4105C5H	ABC transporter
Tharo_3122	ENOG4107RT3	EamA-like transporter family
Tharo_3124	ENOG41081YB	ApbE family
Tharo_3125	ENOG4105D7Z	glutathione synthase
Tharo_3127	ENOG4105C26	Dehydrogenase
Tharo_3128	ENOG4105DHI	Methyltransferase
Tharo_3129	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
Tharo_3135	ENOG41090HT	Inherit from COG: transposase
Tharo_3137	ENOG4105XEZ	This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the
Tharo_3139	ENOG4107RCI	amp-dependent synthetase and ligase
Tharo_3141	ENOG4105C6T	cysteine synthase
Tharo_3142	ENOG4105K78	MarR family Transcriptional regulator
Tharo_3143	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
Tharo_3151	ENOG4105K5B	UPF0225 protein
Tharo_3154	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
Tharo_3155	ENOG4105E0C	molybdate abc transporter
Tharo_3156	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
Tharo_3157	ENOG4105CHR	reductase
Tharo_3159	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tharo_3162	ENOG4107RQ2	Cytochrome c oxidase, subunit I
Tharo_3163	ENOG4105NAA	Cytochrome C oxidase, subunit II
Tharo_3165	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
Tharo_3168	ENOG4107QMH	DNA methylase
Tharo_3169	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Tharo_3173	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Tharo_3175	ENOG4105BZU	Histidine kinase
Tharo_3177	ENOG4105CKI	cobalamin synthesis protein
Tharo_3179	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
Tharo_3180	ENOG4105BZS	acriflavin resistance protein
Tharo_3181	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
Tharo_3182	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
Tharo_3183	ENOG4105C2M	dna polymerase I
Tharo_3184	ENOG4108URH	decarboxylase
Tharo_3187	ENOG4105CUV	Homoserine Kinase
Tharo_3190	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Tharo_3191	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
Tharo_3192	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
Tharo_3193	ENOG4108Z03	MAF-like protein
Tharo_3194	ENOG4105C03	ribonuclease
Tharo_3195	ENOG4105C8Q	Methyl-accepting chemotaxis
Tharo_3198	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Tharo_3199	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Tharo_3200	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Tharo_3202	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Tharo_3203	ENOG4105D1S	lipid A biosynthesis
Tharo_3205	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Tharo_3208	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
Tharo_3209	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
Tharo_3210	ENOG41081F0	Precorrin-8x methylmutase
Tharo_3211	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
Tharo_3212	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
Tharo_3213	ENOG4105DVK	Precorrin-2 c20-methyltransferase
Tharo_3214	ENOG4108P62	biosynthesis protein (CbiG)
Tharo_3216	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tharo_3217	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Tharo_3218	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
Tharo_3219	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
Tharo_3220	ENOG4105EHG	Permease protein
Tharo_3221	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Tharo_3223	ENOG4108YZT	Adenosylcobinamide kinase
Tharo_3225	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
Tharo_3226	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
Tharo_3232	ENOG4105VUH	addiction module killer protein
Tharo_3242	ENOG4105CVJ	phosphoglycerate mutase
Tharo_3243	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Tharo_3244	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
Tharo_3245	ENOG4105XA0	heptosyltransferase ii
Tharo_3246	ENOG4105D16	lipopolysaccharide heptosyltransferase i
Tharo_3247	ENOG4107RJ7	Glycosyl transferase (Group 1
Tharo_3248	ENOG4107543	(lipo)polysaccharide
Tharo_3250	ENOG4105E3J	oxidoreductase
Tharo_3255	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Tharo_3256	ENOG4105DHQ	Histidine kinase
Tharo_3257	ENOG4105E0M	Sulfatase
Tharo_3259	ENOG4105FQR	PH-inducible protein involved in stress response
Tharo_3260	ENOG4105BZ1	(ABC) transporter
Tharo_3265	ENOG4105EXC	Acyl-transferase
Tharo_3267	ENOG4105ESV	Glycosyl transferase, family 4
Tharo_3271	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Tharo_3272	ENOG4105VF7	tolerance protein
Tharo_3273	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
Tharo_3276	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Tharo_3277	ENOG4107YIM	Involved in the transcription termination process (By similarity)
Tharo_3278	ENOG41081J6	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
Tharo_3279	ENOG4107RSS	Hydrogenase accessory protein HypB
Tharo_3285	ENOG4105C26	Dehydrogenase
Tharo_3289	ENOG4105C1J	atp-dependent rna helicase
Tharo_3290	ENOG4105K70	DNA-binding protein
Tharo_3293	ENOG4105CEN	a g-specific adenine glycosylase
Tharo_3295	ENOG4105C0A	alcohol dehydrogenase
Tharo_3296	ENOG4105C26	Dehydrogenase
Tharo_3297	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
Tharo_3299	ENOG4105EN6	Membrane
Tharo_3301	ENOG4105C5X	domain protein
Tharo_3302	ENOG4105D82	Glutamate dehydrogenase
Tharo_3305	ENOG4105D94	Major Facilitator Superfamily
Tharo_3306	ENOG4106NZI	LysR family Transcriptional regulator
Tharo_3309	ENOG4105CFP	Peptidase U32
Tharo_3310	ENOG4107ZXU	DSBA oxidoreductase
Tharo_3312	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tharo_3317	ENOG4105DSJ	YicC domain protein
Tharo_3319	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Tharo_3320	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Tharo_3321	ENOG4105CSA	Coproporphyrinogen iii oxidase
Tharo_3322	ENOG4105CHB	tonB-dependent Receptor
Tharo_3324	ENOG4105CSR	polyphosphate kinase 2
Tharo_3328	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Tharo_3334	ENOG4105D07	Signal peptide peptidase, SppA
Tharo_3335	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Tharo_3336	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Tharo_3337	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Tharo_3338	ENOG4105DWV	Homoserine O-trans-acetylase
Tharo_3339	ENOG4105DWV	Homoserine O-trans-acetylase
Tharo_3341	ENOG4105EYM	Major Facilitator superfamily
Tharo_3343	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tharo_3349	ENOG4105CB5	ATP-dependent DNA helicase recG
Tharo_3350	ENOG4105DHQ	Histidine kinase
Tharo_3351	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Tharo_3359	ENOG4105IFJ	Histidine kinase
Tharo_3360	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Tharo_3363	ENOG4108IV0	ABC, transporter
Tharo_3364	ENOG4105C0Z	ABC transporter
Tharo_3365	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Tharo_3366	ENOG4105C32	Amino acid ABC transporter (Permease)
Tharo_3368	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
Tharo_3371	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Tharo_3376	ENOG4105E3J	oxidoreductase
Tharo_3377	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Tharo_3378	ENOG4105DHQ	Histidine kinase
Tharo_3380	ENOG41077A9	carbonic anhydrase
Tharo_3383	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Tharo_3384	ENOG4105C25	Primosomal protein n'
Tharo_3385	ENOG4105D7V	transposase
Tharo_3386	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Tharo_3387	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Tharo_3388	ENOG4105C1A	potassium transporter peripheral membrane
Tharo_3389	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tharo_3390	ENOG4105ES5	Histidine kinase
Tharo_3392	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Tharo_3393	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Tharo_3394	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Tharo_3396	ENOG4105DZR	Type I site-specific deoxyribonuclease
Tharo_3398	ENOG4105EKX	Restriction modification system DNA (Specificity
Tharo_3399	ENOG4105CVR	type I restriction-modification system
Tharo_3400	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Tharo_3401	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Tharo_3402	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Tharo_3403	ENOG4105X5M	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Tharo_3424	ENOG4105YPM	F pilin acetylation protein TraX
Tharo_3432	ENOG4108C33	Resolvase
Tharo_3445	ENOG4108KTG	Membrane protein, drug metabolite transporter
Tharo_3449	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)