locus-tag	class	description
Tchl_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tchl_0005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tchl_0012	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tchl_0014	COG3609	addiction module antidote protein, CC2985 family
Tchl_0025	COG1451	nucleotide metabolic process
Tchl_0026	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Tchl_0029	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tchl_0030	COG2814	Major facilitator Superfamily
Tchl_0032	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tchl_0036	COG1196	nuclear chromosome segregation
Tchl_0036	COG3264	Mechanosensitive ion channel
Tchl_0038	COG1116	anion transmembrane transporter activity
Tchl_0039	COG0390	transport system, permease component
Tchl_0040	COG0679	Auxin Efflux Carrier
Tchl_0041	COG0114	fumarate hydratase activity
Tchl_0044	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Tchl_0049	COG2974	May be involved in recombination
Tchl_0051	COG1187	pseudouridine synthase activity
Tchl_0054	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tchl_0058	COG2212	antiporter activity
Tchl_0059	COG1863	multisubunit Na H antiporter MnhE subunit
Tchl_0060	COG0651	ATP synthesis coupled electron transport
Tchl_0061	COG1006	Multisubunit Na H antiporter MnhC subunit
Tchl_0062	COG2111	Na H antiporter
Tchl_0062	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tchl_0067	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tchl_0069	COG3909	cytochrome
Tchl_0070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tchl_0072	COG0783	Belongs to the Dps family
Tchl_0076	COG2922	Belongs to the Smg family
Tchl_0077	COG0758	DNA mediated transformation
Tchl_0078	COG1652	LysM domain
Tchl_0079	COG0242	peptide deformylase activity
Tchl_0080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tchl_0081	COG0501	Belongs to the peptidase M48B family
Tchl_0082	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Tchl_0086	COG1132	(ABC) transporter
Tchl_0087	COG0420	3'-5' exonuclease activity
Tchl_0095	COG1960	acyl-CoA dehydrogenase activity
Tchl_0097	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tchl_0104	COG0243	molybdopterin cofactor binding
Tchl_0105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tchl_0107	COG1910	domain protein
Tchl_0108	COG1960	acyl-CoA dehydrogenase activity
Tchl_0109	COG1960	acyl-CoA dehydrogenase activity
Tchl_0112	COG0445	tRNA wobble uridine modification
Tchl_0113	COG0357	Ribosomal RNA small subunit methyltransferase G
Tchl_0114	COG1192	Involved in chromosome partitioning
Tchl_0115	COG1475	DNA binding
Tchl_0116	COG0477	Major facilitator Superfamily
Tchl_0119	COG0356	it plays a direct role in the translocation of protons across the membrane
Tchl_0121	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tchl_0122	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tchl_0123	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tchl_0124	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tchl_0125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tchl_0126	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tchl_0129	COG2226	methyltransferase
Tchl_0131	COG0745	RESPONSE REGULATOR receiver
Tchl_0134	COG0121	glutamine amidotransferase
Tchl_0135	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tchl_0137	COG4372	Transposase
Tchl_0141	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tchl_0142	COG0154	amidase activity
Tchl_0143	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tchl_0144	COG1077	Cell shape determining protein MreB Mrl
Tchl_0146	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Tchl_0147	COG0768	penicillin binding
Tchl_0148	COG0772	Belongs to the SEDS family
Tchl_0150	COG1686	Belongs to the peptidase S11 family
Tchl_0152	COG2921	Belongs to the UPF0250 family
Tchl_0153	COG0321	lipoyl(octanoyl) transferase activity
Tchl_0154	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tchl_0157	COG0210	DNA helicase
Tchl_0165	COG1074	ATP-dependent DNA helicase activity
Tchl_0166	COG5002	protein histidine kinase activity
Tchl_0170	COG2132	Multicopper oxidase
Tchl_0174	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_0175	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_0198	COG0583	DNA-binding transcription factor activity
Tchl_0216	COG0277	FAD linked oxidase domain protein
Tchl_0217	COG1944	ATP diphosphatase activity
Tchl_0218	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tchl_0219	COG2336	PFAM SpoVT AbrB
Tchl_0220	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tchl_0221	COG3657	addiction module killer protein
Tchl_0225	COG1959	2 iron, 2 sulfur cluster binding
Tchl_0227	COG0583	DNA-binding transcription factor activity
Tchl_0230	COG0625	glutathione transferase activity
Tchl_0231	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_0241	COG0194	GDP metabolic process
Tchl_0242	COG1758	RNA polymerase activity
Tchl_0243	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tchl_0245	COG2176	DNA-directed DNA polymerase activity
Tchl_0245	COG5002	protein histidine kinase activity
Tchl_0247	COG3850	Histidine kinase
Tchl_0248	COG2197	response regulator
Tchl_0249	COG4133	protoheme IX ABC transporter activity
Tchl_0250	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tchl_0253	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Tchl_0255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tchl_0256	COG3088	subunit of a heme lyase
Tchl_0257	COG4235	cytochrome complex assembly
Tchl_0258	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tchl_0274	COG0776	regulation of translation
Tchl_0278	COG2326	polyphosphate kinase activity
Tchl_0280	COG0583	DNA-binding transcription factor activity
Tchl_0284	COG4372	Transposase
Tchl_0289	COG4974	Belongs to the 'phage' integrase family
Tchl_0290	COG1285	pathogenesis
Tchl_0292	COG0583	DNA-binding transcription factor activity
Tchl_0297	COG1484	DNA-dependent DNA replication
Tchl_0298	COG4584	PFAM Integrase catalytic
Tchl_0320	COG2003	Belongs to the UPF0758 family
Tchl_0337	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tchl_0343	COG0583	DNA-binding transcription factor activity
Tchl_0344	COG1396	sequence-specific DNA binding
Tchl_0346	COG0582	viral genome integration into host DNA
Tchl_0348	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tchl_0349	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tchl_0350	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tchl_0350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tchl_0351	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Tchl_0358	COG1558	bacterial-type flagellum-dependent cell motility
Tchl_0359	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tchl_0360	COG1749	Flagellar hook protein flgE
Tchl_0361	COG4787	bacterial-type flagellum-dependent cell motility
Tchl_0362	COG4786	Flagellar basal body rod
Tchl_0363	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Tchl_0364	COG1706	bacterial-type flagellum-dependent cell motility
Tchl_0366	COG1256	bacterial-type flagellum assembly
Tchl_0369	COG1987	bacterial-type flagellum assembly
Tchl_0370	COG1338	Plays a role in the flagellum-specific transport system
Tchl_0374	COG1580	Controls the rotational direction of flagella during chemotaxis
Tchl_0380	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tchl_0383	COG1334	flagellar protein FlaG
Tchl_0384	COG0840	transmembrane signaling receptor activity
Tchl_0386	COG1487	ribonuclease activity
Tchl_0390	COG4372	Transposase
Tchl_0416	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tchl_0420	COG2257	FlhB HrpN YscU SpaS Family
Tchl_0424	COG1360	Flagellar Motor Protein
Tchl_0425	COG2198	Histidine kinase
Tchl_0425	COG0643	Histidine kinase
Tchl_0426	COG0835	chemotaxis
Tchl_0427	COG0840	transmembrane signaling receptor activity
Tchl_0428	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tchl_0429	COG2201	protein-glutamate methylesterase activity
Tchl_0430	COG0745	RESPONSE REGULATOR receiver
Tchl_0433	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tchl_0437	COG1191	sigma factor activity
Tchl_0438	COG0488	(ABC) transporter
Tchl_0439	COG2203	Gaf domain
Tchl_0439	COG4251	negative regulation of phosphorylation
Tchl_0439	COG3706	GGDEF domain
Tchl_0439	COG5001	Diguanylate cyclase
Tchl_0440	COG0625	glutathione transferase activity
Tchl_0445	COG0513	Belongs to the DEAD box helicase family
Tchl_0447	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
Tchl_0450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tchl_0451	COG0393	Putative heavy-metal-binding
Tchl_0452	COG0697	spore germination
Tchl_0453	COG0217	transcriptional regulatory protein
Tchl_0454	COG0583	DNA-binding transcription factor activity
Tchl_0458	COG0433	COG0433 Predicted ATPase
Tchl_0459	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Tchl_0460	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tchl_0461	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tchl_0462	COG0688	phosphatidylethanolamine metabolic process
Tchl_0463	COG0840	transmembrane signaling receptor activity
Tchl_0464	COG0513	Belongs to the DEAD box helicase family
Tchl_0466	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tchl_0469	COG1492	cobalamin metabolic process
Tchl_0470	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tchl_0470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tchl_0471	COG4654	Cytochrome c, class I
Tchl_0472	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Tchl_0477	COG3852	Histidine kinase
Tchl_0478	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tchl_0480	COG0746	molybdenum cofactor guanylyltransferase activity
Tchl_0487	COG0243	molybdopterin cofactor binding
Tchl_0487	COG3383	formate dehydrogenase (NAD+) activity
Tchl_0488	COG0437	4 iron, 4 sulfur cluster binding
Tchl_0498	COG0540	Belongs to the ATCase OTCase family
Tchl_0499	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tchl_0500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tchl_0501	COG1678	Uncharacterized ACR, COG1678
Tchl_0502	COG0415	Belongs to the DNA photolyase family
Tchl_0503	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Tchl_0506	COG0352	thiamine-phosphate diphosphorylase activity
Tchl_0507	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tchl_0508	COG3622	Belongs to the hyi family
Tchl_0509	COG2239	Acts as a magnesium transporter
Tchl_0510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tchl_0511	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tchl_0513	COG0557	exoribonuclease II activity
Tchl_0514	COG2226	methyltransferase
Tchl_0515	COG3150	esterase
Tchl_0516	COG1968	undecaprenyl-diphosphatase activity
Tchl_0517	COG1618	nucleotide phosphatase activity, acting on free nucleotides
Tchl_0517	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Tchl_0518	COG1643	Atp-dependent helicase
Tchl_0521	COG0360	Binds together with S18 to 16S ribosomal RNA
Tchl_0522	COG2965	DNA replication, synthesis of RNA primer
Tchl_0523	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tchl_0524	COG0359	binds to the 23S rRNA
Tchl_0525	COG0305	Participates in initiation and elongation during chromosome replication
Tchl_0531	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tchl_0532	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tchl_0533	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Tchl_0536	COG0494	nUDIX hydrolase
Tchl_0537	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Tchl_0538	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Tchl_0539	COG0237	dephospho-CoA kinase activity
Tchl_0541	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tchl_0542	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tchl_0545	COG3852	Histidine kinase
Tchl_0548	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tchl_0550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tchl_0551	COG3568	Endonuclease Exonuclease Phosphatase
Tchl_0553	COG1832	CoA-binding protein
Tchl_0554	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tchl_0555	COG3245	cytochrome
Tchl_0565	COG4263	nitrous-oxide reductase activity
Tchl_0568	COG3706	GGDEF domain
Tchl_0569	COG0012	GTP binding
Tchl_0570	COG0193	aminoacyl-tRNA hydrolase activity
Tchl_0571	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tchl_0572	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tchl_0574	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tchl_0575	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Tchl_0577	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tchl_0578	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tchl_0579	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tchl_0580	COG0742	ribosomal rna small subunit methyltransferase
Tchl_0581	COG0612	Peptidase, M16
Tchl_0582	COG0612	Peptidase, M16
Tchl_0584	COG2884	Cell division ATP-binding protein ftsE
Tchl_0586	COG0450	alkyl hydroperoxide reductase
Tchl_0587	COG3634	alkyl hydroperoxide reductase activity
Tchl_0588	COG1132	(ABC) transporter
Tchl_0592	COG3550	peptidyl-serine autophosphorylation
Tchl_0593	COG1396	sequence-specific DNA binding
Tchl_0599	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tchl_0600	COG1702	phosphate starvation-inducible protein PhoH
Tchl_0601	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tchl_0602	COG4535	Mg2 and Co2 transporter CorC
Tchl_0603	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Tchl_0604	COG0752	glycyl-tRNA synthetase alpha subunit
Tchl_0605	COG0751	glycine-tRNA ligase activity
Tchl_0606	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Tchl_0607	COG0204	Acyl-transferase
Tchl_0610	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Tchl_0613	COG4537	Required for transformation and DNA binding
Tchl_0617	COG1459	type II secretion system
Tchl_0620	COG1127	ABC transporter
Tchl_0621	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tchl_0622	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Tchl_0623	COG2853	Lipoprotein
Tchl_0626	COG1131	(ABC) transporter
Tchl_0627	COG0842	Transport permease protein
Tchl_0629	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tchl_0630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tchl_0631	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tchl_0632	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tchl_0633	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tchl_0634	COG0131	Imidazoleglycerol-phosphate dehydratase
Tchl_0635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tchl_0636	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tchl_0637	COG0107	imidazoleglycerol-phosphate synthase activity
Tchl_0638	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tchl_0639	COG0140	phosphoribosyl-ATP diphosphatase activity
Tchl_0640	COG0537	adenosine 5'-monophosphoramidase activity
Tchl_0641	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tchl_0642	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tchl_0643	COG0805	protein transport
Tchl_0645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tchl_0648	COG0045	succinate-CoA ligase (ADP-forming) activity
Tchl_0649	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tchl_0650	COG1716	ATPase activity
Tchl_0654	COG0546	phosphoglycolate phosphatase activity
Tchl_0657	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tchl_0658	COG0134	indole-3-glycerol-phosphate synthase activity
Tchl_0660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tchl_0667	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tchl_0669	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Tchl_0675	COG0109	protoheme IX farnesyltransferase activity
Tchl_0676	COG1999	signal sequence binding
Tchl_0681	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tchl_0682	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tchl_0689	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Tchl_0690	COG1040	competence protein
Tchl_0693	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_0695	COG2119	membrane
Tchl_0696	COG2895	sulfate adenylyltransferase (ATP) activity
Tchl_0697	COG0175	sulfate reduction
Tchl_0699	COG0175	sulfate reduction
Tchl_0702	COG0730	response to heat
Tchl_0703	COG0583	DNA-binding transcription factor activity
Tchl_0704	COG0252	asparaginase activity
Tchl_0706	COG5265	(ABC) transporter
Tchl_0708	COG1960	acyl-CoA dehydrogenase activity
Tchl_0709	COG1607	acyl-coa hydrolase
Tchl_0710	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_0710	COG1024	Enoyl-CoA hydratase
Tchl_0711	COG0183	Belongs to the thiolase family
Tchl_0713	COG1805	sodium ion transport
Tchl_0720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tchl_0721	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Tchl_0724	COG0284	orotidine-5'-phosphate decarboxylase activity
Tchl_0725	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tchl_0732	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_0741	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tchl_0742	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_0749	COG1965	Belongs to the frataxin family
Tchl_0756	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tchl_0757	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tchl_0758	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tchl_0759	COG0067	glutamate synthase
Tchl_0759	COG0070	glutamate synthase
Tchl_0759	COG0069	glutamate synthase activity
Tchl_0762	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tchl_0764	COG0405	Gamma-glutamyltransferase
Tchl_0765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tchl_0768	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Tchl_0770	COG2030	dehydratase
Tchl_0772	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tchl_0773	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tchl_0774	COG5002	protein histidine kinase activity
Tchl_0776	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Tchl_0779	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_0780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_0782	COG3058	Necessary for formate dehydrogenase activity
Tchl_0785	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Tchl_0789	COG0243	molybdopterin cofactor binding
Tchl_0790	COG3023	N-Acetylmuramoyl-L-alanine amidase
Tchl_0791	COG0741	lytic transglycosylase activity
Tchl_0792	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Tchl_0798	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tchl_0798	COG2111	Na H antiporter
Tchl_0799	COG1006	Multisubunit Na H antiporter MnhC subunit
Tchl_0800	COG0651	ATP synthesis coupled electron transport
Tchl_0802	COG2212	antiporter activity
Tchl_0807	COG1187	pseudouridine synthase activity
Tchl_0808	COG1320	monovalent cation:proton antiporter activity
Tchl_0809	COG2212	antiporter activity
Tchl_0810	COG1863	multisubunit Na H antiporter MnhE subunit
Tchl_0813	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tchl_0813	COG2111	Na H antiporter
Tchl_0815	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tchl_0817	COG4372	Transposase
Tchl_0821	COG0732	type I restriction modification DNA specificity domain
Tchl_0822	COG4804	nuclease activity
Tchl_0823	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tchl_0824	COG0577	efflux transmembrane transporter activity
Tchl_0824	COG1136	(ABC) transporter
Tchl_0826	COG0577	efflux transmembrane transporter activity
Tchl_0826	COG1136	(ABC) transporter
Tchl_0829	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tchl_0830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tchl_0831	COG2885	chlorophyll binding
Tchl_0831	COG3047	cAMP biosynthetic process
Tchl_0832	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tchl_0833	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tchl_0834	COG0351	phosphomethylpyrimidine kinase
Tchl_0835	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tchl_0840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tchl_0841	COG4115	mRNA cleavage
Tchl_0847	COG2264	protein methyltransferase activity
Tchl_0848	COG0439	Biotin carboxylase
Tchl_0849	COG0511	ligase activity, forming carbon-carbon bonds
Tchl_0850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tchl_0852	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tchl_0854	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tchl_0855	COG0792	nuclease activity
Tchl_0857	COG0418	dihydroorotase activity
Tchl_0858	COG0840	transmembrane signaling receptor activity
Tchl_0859	COG2001	Belongs to the MraZ family
Tchl_0860	COG0275	rRNA processing
Tchl_0863	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tchl_0864	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tchl_0865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tchl_0866	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tchl_0867	COG0772	Belongs to the SEDS family
Tchl_0868	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tchl_0869	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tchl_0870	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tchl_0871	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tchl_0873	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tchl_0874	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Tchl_0879	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Tchl_0880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tchl_0881	COG0438	transferase activity, transferring glycosyl groups
Tchl_0884	COG4456	Virulence-associated protein
Tchl_0887	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tchl_0892	COG0297	glycogen (starch) synthase activity
Tchl_0896	COG2089	acid synthase
Tchl_0898	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tchl_0901	COG1083	cytidylyl-transferase
Tchl_0903	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tchl_0904	COG1086	Polysaccharide biosynthesis protein
Tchl_0917	COG0653	protein targeting
Tchl_0918	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tchl_0920	COG5002	protein histidine kinase activity
Tchl_0920	COG5001	Diguanylate cyclase
Tchl_0920	COG3447	MASE1 domain protein
Tchl_0924	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tchl_0925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tchl_0926	COG1862	Preprotein translocase
Tchl_0927	COG0343	queuine tRNA-ribosyltransferase activity
Tchl_0928	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tchl_0939	COG0583	DNA-binding transcription factor activity
Tchl_0941	COG0670	Belongs to the BI1 family
Tchl_0942	COG0825	malonyl-CoA metabolic process
Tchl_0943	COG0037	tRNA processing
Tchl_0949	COG0105	UTP biosynthetic process
Tchl_0950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tchl_0953	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tchl_0954	COG0124	histidyl-tRNA synthetase
Tchl_0956	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tchl_0957	COG1160	GTP binding
Tchl_0958	COG1923	regulation of RNA biosynthetic process
Tchl_0959	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tchl_0960	COG0330	HflC and HflK could
Tchl_0961	COG0330	HflC and HflK could
Tchl_0963	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Tchl_0964	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tchl_0967	COG0557	exoribonuclease II activity
Tchl_0968	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tchl_0969	COG0778	Nitroreductase
Tchl_0970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tchl_0972	COG2223	nitrite transmembrane transporter activity
Tchl_0973	COG2815	serine threonine protein kinase
Tchl_0973	COG0515	serine threonine protein kinase
Tchl_0974	COG0243	molybdopterin cofactor binding
Tchl_0979	COG0745	RESPONSE REGULATOR receiver
Tchl_0983	COG5001	Diguanylate cyclase
Tchl_0983	COG2203	Gaf domain
Tchl_0983	COG4251	negative regulation of phosphorylation
Tchl_0983	COG3706	GGDEF domain
Tchl_0984	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tchl_0986	COG0471	metal ion transport
Tchl_0986	COG3273	potassium ion transport
Tchl_0988	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tchl_0989	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tchl_0990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tchl_0991	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tchl_0992	COG0723	plastoquinol--plastocyanin reductase activity
Tchl_0993	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Tchl_0994	COG2857	Cytochrome c1
Tchl_0995	COG0625	glutathione transferase activity
Tchl_0996	COG2969	positive regulation of protein catabolic process
Tchl_0998	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tchl_0999	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tchl_1003	COG1335	isochorismatase
Tchl_1004	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tchl_1006	COG0459	protein refolding
Tchl_1007	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_1008	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tchl_1009	COG0022	dehydrogenase e1 component
Tchl_1009	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tchl_1011	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tchl_1012	COG1902	pentaerythritol trinitrate reductase activity
Tchl_1014	COG1067	ATP-dependent peptidase activity
Tchl_1015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tchl_1016	COG0459	protein refolding
Tchl_1017	COG0745	RESPONSE REGULATOR receiver
Tchl_1018	COG0642	Histidine kinase
Tchl_1020	COG2814	Major facilitator Superfamily
Tchl_1021	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tchl_1022	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tchl_1023	COG2890	protein-(glutamine-N5) methyltransferase activity
Tchl_1024	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tchl_1027	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tchl_1030	COG4536	flavin adenine dinucleotide binding
Tchl_1032	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tchl_1038	COG2070	2-Nitropropane dioxygenase
Tchl_1039	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_1040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_1042	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tchl_1043	COG1238	metal cluster binding
Tchl_1044	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tchl_1045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tchl_1047	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tchl_1047	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tchl_1049	COG0720	synthase
Tchl_1052	COG0527	aspartate kinase activity
Tchl_1055	COG3384	dioxygenase
Tchl_1058	COG2159	amidohydrolase
Tchl_1064	COG0667	Aldo Keto reductase
Tchl_1065	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tchl_1066	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tchl_1071	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tchl_1073	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_1075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tchl_1081	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_1082	COG1024	Enoyl-CoA hydratase
Tchl_1083	COG0183	Belongs to the thiolase family
Tchl_1085	COG1960	acyl-CoA dehydrogenase activity
Tchl_1086	COG0367	asparagine synthase
Tchl_1087	COG0189	ligase activity
Tchl_1087	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tchl_1088	COG1363	Peptidase, m42
Tchl_1092	COG0277	FAD linked oxidase domain protein
Tchl_1094	COG2910	NAD(P)H-binding
Tchl_1096	COG3712	iron ion homeostasis
Tchl_1097	COG1595	DNA-templated transcription, initiation
Tchl_1100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tchl_1110	COG4177	L-phenylalanine transmembrane transporter activity
Tchl_1111	COG0411	ABC transporter
Tchl_1115	COG0745	RESPONSE REGULATOR receiver
Tchl_1116	COG2205	protein histidine kinase activity
Tchl_1121	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_1125	COG0745	RESPONSE REGULATOR receiver
Tchl_1126	COG0642	Histidine kinase
Tchl_1133	COG1136	(ABC) transporter
Tchl_1133	COG0577	efflux transmembrane transporter activity
Tchl_1135	COG2814	Major facilitator Superfamily
Tchl_1137	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tchl_1137	COG2813	Specifically methylates the guanine in position
Tchl_1138	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tchl_1140	COG2022	thiamine diphosphate biosynthetic process
Tchl_1141	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Tchl_1142	COG0616	signal peptide processing
Tchl_1143	COG1881	PFAM PEBP family protein
Tchl_1148	COG1629	transport
Tchl_1151	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tchl_1152	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tchl_1153	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tchl_1155	COG1561	YicC-like family, N-terminal region
Tchl_1161	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Tchl_1164	COG0004	ammonium transporteR
Tchl_1165	COG0583	DNA-binding transcription factor activity
Tchl_1166	COG2814	Major facilitator Superfamily
Tchl_1169	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tchl_1170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tchl_1172	COG2860	membrane
Tchl_1174	COG3284	Transcriptional regulator
Tchl_1175	COG1012	belongs to the aldehyde dehydrogenase family
Tchl_1176	COG1454	alcohol dehydrogenase
Tchl_1179	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tchl_1181	COG0776	regulation of translation
Tchl_1182	COG0513	Belongs to the DEAD box helicase family
Tchl_1185	COG1012	belongs to the aldehyde dehydrogenase family
Tchl_1187	COG0309	Hydrogenase expression formation protein (HypE)
Tchl_1188	COG0409	Hydrogenase expression formation protein
Tchl_1189	COG0298	carbon dioxide binding
Tchl_1190	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tchl_1193	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tchl_1194	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tchl_1197	COG4232	protein-disulfide reductase activity
Tchl_1200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tchl_1200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Tchl_1202	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tchl_1204	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Tchl_1204	COG2755	lipolytic protein G-D-S-L family
Tchl_1205	COG2192	nodulation
Tchl_1207	COG0438	transferase activity, transferring glycosyl groups
Tchl_1208	COG0110	maltose O-acetyltransferase activity
Tchl_1209	COG2226	methyltransferase
Tchl_1211	COG1132	(ABC) transporter
Tchl_1214	COG1368	sulfuric ester hydrolase activity
Tchl_1216	COG2194	sulfuric ester hydrolase activity
Tchl_1217	COG0642	Histidine kinase
Tchl_1218	COG0745	RESPONSE REGULATOR receiver
Tchl_1222	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tchl_1225	COG0438	transferase activity, transferring glycosyl groups
Tchl_1226	COG0859	PFAM glycosyl transferase family 9
Tchl_1228	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tchl_1230	COG0406	alpha-ribazole phosphatase activity
Tchl_1234	COG2801	Transposase and inactivated derivatives
Tchl_1237	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Tchl_1239	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tchl_1240	COG4636	protein conserved in cyanobacteria
Tchl_1242	COG4206	TonB-dependent receptor
Tchl_1243	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tchl_1244	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Tchl_1246	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tchl_1246	COG1648	precorrin-2 dehydrogenase activity
Tchl_1252	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Tchl_1258	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tchl_1260	COG1560	Kdo2-lipid A biosynthetic process
Tchl_1261	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tchl_1263	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Tchl_1264	COG2255	four-way junction helicase activity
Tchl_1265	COG0632	four-way junction helicase activity
Tchl_1268	COG1530	ribonuclease E activity
Tchl_1269	COG0424	maF-like protein
Tchl_1270	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Tchl_1271	COG0799	negative regulation of ribosome biogenesis
Tchl_1272	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tchl_1275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Tchl_1279	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tchl_1279	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tchl_1281	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_1282	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_1283	COG1538	Outer membrane efflux protein
Tchl_1284	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Tchl_1285	COG0523	cobalamin synthesis protein
Tchl_1289	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tchl_1293	COG0653	protein targeting
Tchl_1298	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tchl_1304	COG0842	Transport permease protein
Tchl_1305	COG0842	Transport permease protein
Tchl_1306	COG1131	(ABC) transporter
Tchl_1308	COG1309	transcriptional regulator
Tchl_1310	COG1739	Uncharacterized protein family UPF0029
Tchl_1312	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Tchl_1313	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tchl_1316	COG2204	response regulator
Tchl_1318	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_1322	COG1611	Belongs to the LOG family
Tchl_1323	COG2267	carboxylic ester hydrolase activity
Tchl_1324	COG3012	SEC-C Motif Domain Protein
Tchl_1325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tchl_1329	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tchl_1335	COG3647	Membrane
Tchl_1336	COG3189	MarR family transcriptional regulator
Tchl_1337	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tchl_1339	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_1340	COG0827	DNA restriction-modification system
Tchl_1340	COG0732	type I restriction modification DNA specificity domain
Tchl_1343	COG2226	methyltransferase
Tchl_1344	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Tchl_1344	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Tchl_1344	COG0506	proline dehydrogenase activity
Tchl_1345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tchl_1347	COG0189	ligase activity
Tchl_1350	COG0697	spore germination
Tchl_1353	COG0488	(ABC) transporter
Tchl_1358	COG4191	Histidine kinase
Tchl_1359	COG2204	response regulator
Tchl_1367	COG0004	ammonium transporteR
Tchl_1368	COG0347	Belongs to the P(II) protein family
Tchl_1375	COG2814	Major facilitator Superfamily
Tchl_1377	COG0410	ABC transporter
Tchl_1378	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tchl_1384	COG3781	membrane
Tchl_1386	COG3321	synthase
Tchl_1386	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_1386	COG0604	alcohol dehydrogenase
Tchl_1387	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_1388	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_1392	COG1024	Enoyl-CoA hydratase
Tchl_1393	COG1881	PFAM PEBP family protein
Tchl_1394	COG4115	mRNA cleavage
Tchl_1395	COG2161	toxin-antitoxin pair type II binding
Tchl_1400	COG2814	Major facilitator Superfamily
Tchl_1419	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tchl_1420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tchl_1421	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Tchl_1422	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tchl_1423	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tchl_1424	COG3876	Protein conserved in bacteria
Tchl_1428	COG0668	transmembrane transport
Tchl_1432	COG0659	secondary active sulfate transmembrane transporter activity
Tchl_1434	COG0180	Tryptophanyl-tRNA synthetase
Tchl_1436	COG0583	DNA-binding transcription factor activity
Tchl_1441	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tchl_1442	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tchl_1443	COG1024	Enoyl-CoA hydratase
Tchl_1445	COG1368	sulfuric ester hydrolase activity
Tchl_1446	COG3706	GGDEF domain
Tchl_1446	COG0745	RESPONSE REGULATOR receiver
Tchl_1453	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tchl_1454	COG1518	maintenance of DNA repeat elements
Tchl_1461	COG0583	DNA-binding transcription factor activity
Tchl_1467	COG2084	Dehydrogenase
Tchl_1469	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_1471	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tchl_1472	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_1475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tchl_1478	COG0523	cobalamin synthesis protein
Tchl_1479	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tchl_1481	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tchl_1482	COG0583	DNA-binding transcription factor activity
Tchl_1501	COG2409	Drug exporters of the RND superfamily
Tchl_1503	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_1504	COG2814	Major facilitator Superfamily
Tchl_1508	COG5002	protein histidine kinase activity
Tchl_1508	COG5001	Diguanylate cyclase
Tchl_1508	COG3447	MASE1 domain protein
Tchl_1509	COG0708	Exodeoxyribonuclease III
Tchl_1510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tchl_1516	COG0037	tRNA processing
Tchl_1517	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_1519	COG0840	transmembrane signaling receptor activity
Tchl_1521	COG0625	glutathione transferase activity
Tchl_1522	COG0617	tRNA 3'-terminal CCA addition
Tchl_1524	COG0702	epimerase
Tchl_1526	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Tchl_1527	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tchl_1528	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Tchl_1530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Tchl_1531	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tchl_1532	COG1137	ATPase activity
Tchl_1533	COG2137	regulation of response to DNA damage stimulus
Tchl_1534	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tchl_1535	COG1546	Belongs to the CinA family
Tchl_1536	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tchl_1537	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Tchl_1542	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tchl_1543	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tchl_1544	COG0018	arginyl-trna synthetase
Tchl_1546	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tchl_1550	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tchl_1552	COG1960	acyl-CoA dehydrogenase activity
Tchl_1557	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tchl_1558	COG1024	Enoyl-CoA hydratase
Tchl_1561	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_1564	COG4948	Mandelate Racemase Muconate Lactonizing
Tchl_1565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tchl_1566	COG1309	transcriptional regulator
Tchl_1567	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tchl_1570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tchl_1571	COG1132	(ABC) transporter
Tchl_1572	COG1404	Belongs to the peptidase S8 family
Tchl_1576	COG0604	alcohol dehydrogenase
Tchl_1577	COG0183	Belongs to the thiolase family
Tchl_1583	COG0439	Biotin carboxylase
Tchl_1584	COG0511	ligase activity, forming carbon-carbon bonds
Tchl_1586	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_1595	COG1012	belongs to the aldehyde dehydrogenase family
Tchl_1599	COG2204	response regulator
Tchl_1601	COG1115	amino acid carrier protein
Tchl_1602	COG1660	Displays ATPase and GTPase activities
Tchl_1605	COG0412	Dienelactone hydrolase
Tchl_1606	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tchl_1608	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Tchl_1609	COG0602	queuosine metabolic process
Tchl_1612	COG0823	Involved in the tonB-independent uptake of proteins
Tchl_1616	COG0824	Thioesterase
Tchl_1617	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tchl_1618	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tchl_1624	COG3706	GGDEF domain
Tchl_1626	COG0330	HflC and HflK could
Tchl_1633	COG4774	siderophore transport
Tchl_1640	COG1595	DNA-templated transcription, initiation
Tchl_1641	COG0659	secondary active sulfate transmembrane transporter activity
Tchl_1642	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_1643	COG0784	Response regulator, receiver
Tchl_1643	COG4191	Histidine kinase
Tchl_1646	COG4772	TonB-dependent receptor
Tchl_1647	COG1538	Outer membrane efflux protein
Tchl_1648	COG1136	(ABC) transporter
Tchl_1648	COG0577	efflux transmembrane transporter activity
Tchl_1649	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_1661	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tchl_1662	COG3132	Protein of unknown function, DUF480
Tchl_1663	COG0129	dihydroxy-acid dehydratase activity
Tchl_1669	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tchl_1669	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tchl_1672	COG0745	RESPONSE REGULATOR receiver
Tchl_1673	COG2205	protein histidine kinase activity
Tchl_1676	COG0730	response to heat
Tchl_1679	COG1121	(ABC) transporter
Tchl_1681	COG0735	belongs to the Fur family
Tchl_1683	COG1136	(ABC) transporter
Tchl_1683	COG0577	efflux transmembrane transporter activity
Tchl_1687	COG1215	transferase activity, transferring glycosyl groups
Tchl_1688	COG2274	protein secretion by the type I secretion system
Tchl_1689	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_1690	COG2197	response regulator
Tchl_1693	COG3706	GGDEF domain
Tchl_1696	COG1024	Enoyl-CoA hydratase
Tchl_1698	COG1253	flavin adenine dinucleotide binding
Tchl_1699	COG1802	Transcriptional regulator
Tchl_1700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tchl_1700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tchl_1701	COG1703	isobutyryl-CoA mutase activity
Tchl_1702	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tchl_1704	COG0439	Biotin carboxylase
Tchl_1705	COG1509	lysine 2,3-aminomutase activity
Tchl_1708	COG1703	isobutyryl-CoA mutase activity
Tchl_1708	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tchl_1708	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tchl_1713	COG4566	intracellular signal transduction
Tchl_1715	COG2201	protein-glutamate methylesterase activity
Tchl_1721	COG4964	Belongs to the GSP D family
Tchl_1724	COG2894	cell division
Tchl_1730	COG2205	protein histidine kinase activity
Tchl_1730	COG0784	Response regulator, receiver
Tchl_1730	COG2198	Histidine kinase
Tchl_1731	COG2197	response regulator
Tchl_1732	COG0277	FAD linked oxidase domain protein
Tchl_1736	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tchl_1738	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tchl_1740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tchl_1741	COG0081	regulation of translation
Tchl_1742	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tchl_1743	COG0222	ribosome binding
Tchl_1744	COG0085	RNA polymerase activity
Tchl_1745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tchl_1746	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tchl_1747	COG0049	tRNA binding
Tchl_1748	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tchl_1749	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tchl_1750	COG0051	transcription antitermination factor activity, RNA binding
Tchl_1751	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tchl_1752	COG0088	Forms part of the polypeptide exit tunnel
Tchl_1753	COG0089	rRNA binding
Tchl_1754	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tchl_1755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tchl_1756	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tchl_1757	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tchl_1758	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tchl_1759	COG0255	Belongs to the universal ribosomal protein uL29 family
Tchl_1760	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tchl_1761	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tchl_1762	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tchl_1763	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tchl_1764	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tchl_1765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tchl_1766	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tchl_1767	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tchl_1768	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tchl_1769	COG1841	ribosomal large subunit assembly
Tchl_1770	COG0200	Binds to the 23S rRNA
Tchl_1771	COG0201	protein transport
Tchl_1772	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tchl_1773	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tchl_1774	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tchl_1775	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tchl_1776	COG0202	RNA polymerase activity
Tchl_1777	COG0203	ribosomal protein L17
Tchl_1778	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tchl_1780	COG2814	Major facilitator Superfamily
Tchl_1781	COG0629	single-stranded DNA binding
Tchl_1783	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tchl_1788	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tchl_1790	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Tchl_1792	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tchl_1793	COG2084	Dehydrogenase
Tchl_1794	COG2084	Dehydrogenase
Tchl_1799	COG1857	crispr-associated protein
Tchl_1801	COG1518	maintenance of DNA repeat elements
Tchl_1803	COG4372	Transposase
Tchl_1806	COG4584	PFAM Integrase catalytic
Tchl_1807	COG1484	DNA-dependent DNA replication
Tchl_1808	COG0235	Class ii aldolase
Tchl_1809	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tchl_1810	COG0436	Aminotransferase
Tchl_1818	COG2151	metal-sulfur cluster biosynthetic enzyme
Tchl_1819	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tchl_1823	COG0071	Belongs to the small heat shock protein (HSP20) family
Tchl_1826	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Tchl_1827	COG0165	Argininosuccinate lyase
Tchl_1828	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tchl_1829	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tchl_1830	COG0181	hydroxymethylbilane synthase activity
Tchl_1832	COG2959	enzyme of heme biosynthesis
Tchl_1833	COG0408	coproporphyrinogen oxidase activity
Tchl_1834	COG3422	double-strand break repair
Tchl_1835	COG0151	Belongs to the GarS family
Tchl_1836	COG0138	bifunctional purine biosynthesis protein purh
Tchl_1837	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Tchl_1839	COG0659	secondary active sulfate transmembrane transporter activity
Tchl_1840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tchl_1840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tchl_1842	COG0489	protein tyrosine kinase activity
Tchl_1843	COG0717	Belongs to the dCTP deaminase family
Tchl_1844	COG1982	Orn Lys Arg decarboxylase major
Tchl_1846	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Tchl_1853	COG3093	addiction module antidote protein HigA
Tchl_1855	COG0582	viral genome integration into host DNA
Tchl_1859	COG0604	alcohol dehydrogenase
Tchl_1860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_1861	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tchl_1862	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tchl_1863	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tchl_1864	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tchl_1866	COG0277	FAD linked oxidase domain protein
Tchl_1868	COG0277	FAD linked oxidase domain protein
Tchl_1869	COG0247	lactate metabolic process
Tchl_1870	COG0631	protein serine/threonine phosphatase activity
Tchl_1871	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tchl_1872	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tchl_1873	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Tchl_1874	COG0513	Belongs to the DEAD box helicase family
Tchl_1875	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Tchl_1876	COG0667	Aldo Keto reductase
Tchl_1877	COG1653	transport
Tchl_1878	COG0142	geranyltranstransferase activity
Tchl_1880	COG0183	Belongs to the thiolase family
Tchl_1881	COG0435	Glutathione S-transferase
Tchl_1882	COG2353	YceI-like domain
Tchl_1884	COG3038	cytochrome b561
Tchl_1886	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Tchl_1887	COG1074	ATP-dependent DNA helicase activity
Tchl_1888	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tchl_1889	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_1890	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tchl_1890	COG1902	pentaerythritol trinitrate reductase activity
Tchl_1897	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tchl_1898	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tchl_1901	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tchl_1907	COG1960	acyl-CoA dehydrogenase activity
Tchl_1912	COG1802	Transcriptional regulator
Tchl_1913	COG0163	prenyltransferase activity
Tchl_1915	COG2414	aldehyde ferredoxin oxidoreductase
Tchl_1916	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tchl_1920	COG0840	transmembrane signaling receptor activity
Tchl_1922	COG0745	RESPONSE REGULATOR receiver
Tchl_1924	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tchl_1925	COG4999	Histidine kinase
Tchl_1925	COG3850	Histidine kinase
Tchl_1925	COG2205	protein histidine kinase activity
Tchl_1925	COG3437	response regulator, receiver
Tchl_1926	COG3706	GGDEF domain
Tchl_1926	COG0745	RESPONSE REGULATOR receiver
Tchl_1933	COG4372	Transposase
Tchl_1940	COG0315	cyclic pyranopterin monophosphate synthase activity
Tchl_1941	COG4783	chaperone-mediated protein folding
Tchl_1942	COG0425	Belongs to the sulfur carrier protein TusA family
Tchl_1943	COG0525	valine-tRNA ligase activity
Tchl_1946	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tchl_1947	COG0795	lipopolysaccharide-transporting ATPase activity
Tchl_1948	COG0795	lipopolysaccharide-transporting ATPase activity
Tchl_1949	COG0335	large ribosomal subunit rRNA binding
Tchl_1950	COG0336	Belongs to the RNA methyltransferase TrmD family
Tchl_1951	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tchl_1952	COG0228	four-way junction DNA binding
Tchl_1955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tchl_1956	COG1183	phosphatidylcholine synthase activity
Tchl_1957	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tchl_1958	COG0440	acetolactate synthase activity
Tchl_1959	COG0028	Belongs to the TPP enzyme family
Tchl_1964	COG0308	aminopeptidase N
Tchl_1965	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Tchl_1965	COG0517	IMP dehydrogenase activity
Tchl_1966	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tchl_1967	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tchl_1970	COG0617	tRNA 3'-terminal CCA addition
Tchl_1972	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tchl_1973	COG0628	permease
Tchl_1974	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tchl_1976	COG0582	viral genome integration into host DNA
Tchl_1981	COG1403	HNH endonuclease
Tchl_1983	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tchl_1991	COG1525	nuclease
Tchl_2001	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tchl_2003	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tchl_2004	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tchl_2005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tchl_2008	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tchl_2009	COG4974	Belongs to the 'phage' integrase family
Tchl_2011	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tchl_2012	COG1466	dna polymerase III delta subunit
Tchl_2014	COG0495	leucyl-tRNA aminoacylation
Tchl_2016	COG0210	DNA helicase
Tchl_2017	COG1192	Involved in chromosome partitioning
Tchl_2018	COG0281	malic enzyme
Tchl_2018	COG0280	phosphate acetyltransferase
Tchl_2021	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tchl_2022	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Tchl_2023	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tchl_2024	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Tchl_2027	COG0006	proline dipeptidase activity
Tchl_2028	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tchl_2030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tchl_2036	COG2814	Major facilitator Superfamily
Tchl_2037	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tchl_2039	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tchl_2040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tchl_2041	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tchl_2042	COG0215	cysteine-tRNA ligase activity
Tchl_2044	COG0484	heat shock protein binding
Tchl_2045	COG0443	Heat shock 70 kDa protein
Tchl_2046	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tchl_2048	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Tchl_2051	COG0287	Prephenate dehydrogenase
Tchl_2052	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tchl_2054	COG0776	regulation of translation
Tchl_2056	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Tchl_2062	COG2261	transglycosylase associated protein
Tchl_2064	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tchl_2065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tchl_2066	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tchl_2067	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tchl_2068	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tchl_2069	COG0072	phenylalanine-tRNA ligase activity
Tchl_2069	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tchl_2070	COG0776	regulation of translation
Tchl_2073	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tchl_2074	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tchl_2076	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tchl_2078	COG2951	lytic endotransglycosylase activity
Tchl_2080	COG0123	including yeast histone deacetylase and acetoin utilization protein
Tchl_2081	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tchl_2082	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Tchl_2084	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tchl_2091	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_2093	COG0011	TIGRFAM Protein of
Tchl_2097	COG1012	belongs to the aldehyde dehydrogenase family
Tchl_2098	COG1024	Enoyl-CoA hydratase
Tchl_2101	COG3396	Phenylacetate-CoA oxygenase
Tchl_2102	COG3460	Phenylacetate-CoA oxygenase
Tchl_2103	COG3396	Phenylacetate-CoA oxygenase
Tchl_2104	COG2151	metal-sulfur cluster biosynthetic enzyme
Tchl_2105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tchl_2106	COG1309	transcriptional regulator
Tchl_2107	COG0183	Belongs to the thiolase family
Tchl_2108	COG0789	Transcriptional regulator
Tchl_2112	COG4658	electron transport chain
Tchl_2115	COG4657	Part of a membrane complex involved in electron transport
Tchl_2138	COG0437	4 iron, 4 sulfur cluster binding
Tchl_2139	COG0243	molybdopterin cofactor binding
Tchl_2140	COG0517	IMP dehydrogenase activity
Tchl_2142	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tchl_2143	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tchl_2143	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tchl_2151	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tchl_2154	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_2157	COG0411	ABC transporter
Tchl_2158	COG0410	ABC transporter
Tchl_2161	COG0187	DNA topoisomerase II activity
Tchl_2162	COG0456	acetyltransferase
Tchl_2162	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Tchl_2166	COG2902	Dehydrogenase
Tchl_2167	COG0504	CTP synthase activity
Tchl_2168	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Tchl_2169	COG0148	phosphopyruvate hydratase activity
Tchl_2170	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Tchl_2171	COG0791	NLP P60 protein
Tchl_2174	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Tchl_2175	COG0306	phosphate transporter
Tchl_2177	COG0302	gtp cyclohydrolase
Tchl_2179	COG4681	YaeQ
Tchl_2181	COG0513	Belongs to the DEAD box helicase family
Tchl_2182	COG1278	Cold shock
Tchl_2183	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Tchl_2184	COG0613	PHP domain protein
Tchl_2185	COG0009	L-threonylcarbamoyladenylate synthase
Tchl_2186	COG1994	Peptidase M50
Tchl_2187	COG0180	Tryptophanyl-tRNA synthetase
Tchl_2188	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tchl_2189	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tchl_2191	COG0779	Required for maturation of 30S ribosomal subunits
Tchl_2192	COG2251	uridine kinase activity
Tchl_2192	COG0195	Participates in both transcription termination and antitermination
Tchl_2193	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tchl_2194	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tchl_2195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tchl_2196	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tchl_2197	COG1185	polyribonucleotide nucleotidyltransferase activity
Tchl_2198	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tchl_2211	COG0822	iron-sulfur transferase activity
Tchl_2212	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tchl_2213	COG0719	Fe-S assembly protein
Tchl_2214	COG0396	ATPase activity
Tchl_2215	COG0719	Fe-S assembly protein
Tchl_2219	COG4251	negative regulation of phosphorylation
Tchl_2220	COG0625	glutathione transferase activity
Tchl_2223	COG2363	Small membrane protein
Tchl_2224	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tchl_2228	COG2205	protein histidine kinase activity
Tchl_2228	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tchl_2229	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tchl_2230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tchl_2230	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Tchl_2231	COG2354	Protein conserved in bacteria
Tchl_2232	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tchl_2233	COG1196	nuclear chromosome segregation
Tchl_2234	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tchl_2237	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Tchl_2241	COG2188	Transcriptional regulator
Tchl_2243	COG1116	anion transmembrane transporter activity
Tchl_2244	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tchl_2246	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tchl_2249	COG0010	Belongs to the arginase family
Tchl_2250	COG1228	amidohydrolase
Tchl_2251	COG0583	DNA-binding transcription factor activity
Tchl_2252	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tchl_2256	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Tchl_2257	COG1984	allophanate hydrolase subunit 2
Tchl_2258	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Tchl_2260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_2264	COG1760	l-serine dehydratase
Tchl_2265	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Tchl_2266	COG3047	cAMP biosynthetic process
Tchl_2270	COG1032	radical SAM domain protein
Tchl_2276	COG1136	(ABC) transporter
Tchl_2277	COG2333	competence protein COMEC
Tchl_2277	COG0658	competence protein
Tchl_2280	COG0501	Belongs to the peptidase M48B family
Tchl_2281	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Tchl_2283	COG0254	rRNA binding
Tchl_2284	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tchl_2286	COG3318	Belongs to the UPF0149 family
Tchl_2286	COG3012	SEC-C Motif Domain Protein
Tchl_2290	COG2501	S4 domain
Tchl_2294	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tchl_2296	COG3177	Filamentation induced by cAMP protein fic
Tchl_2298	COG0741	lytic transglycosylase activity
Tchl_2298	COG0739	heme binding
Tchl_2298	COG1196	nuclear chromosome segregation
Tchl_2299	COG2197	response regulator
Tchl_2302	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tchl_2304	COG4537	Required for transformation and DNA binding
Tchl_2305	COG2165	general secretion pathway protein
Tchl_2311	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tchl_2313	COG2165	general secretion pathway protein
Tchl_2315	COG0039	L-malate dehydrogenase activity
Tchl_2316	COG2188	Transcriptional regulator
Tchl_2319	COG1053	succinate dehydrogenase
Tchl_2320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tchl_2321	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Tchl_2322	COG0372	Belongs to the citrate synthase family
Tchl_2323	COG0567	Dehydrogenase, E1 component
Tchl_2324	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tchl_2325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tchl_2326	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Tchl_2327	COG1199	ATP-dependent helicase activity
Tchl_2328	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tchl_2329	COG0303	'Molybdopterin
Tchl_2330	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Tchl_2331	COG0314	molybdopterin synthase activity
Tchl_2336	COG0471	metal ion transport
Tchl_2336	COG3273	potassium ion transport
Tchl_2339	COG0590	tRNA wobble adenosine to inosine editing
Tchl_2340	COG1376	ErfK ybiS ycfS ynhG family protein
Tchl_2342	COG0354	folic acid binding
Tchl_2343	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tchl_2344	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tchl_2347	COG0084	hydrolase, TatD family'
Tchl_2349	COG0641	radical SAM
Tchl_2350	COG1414	Transcriptional regulator
Tchl_2355	COG2207	Transcriptional regulator
Tchl_2356	COG2807	transmembrane transport
Tchl_2363	COG2824	Alkylphosphonate utilization operon protein PhnA
Tchl_2364	COG1473	amidohydrolase
Tchl_2365	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Tchl_2369	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tchl_2370	COG1067	ATP-dependent peptidase activity
Tchl_2378	COG0556	nucleotide-excision repair
Tchl_2379	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tchl_2380	COG1530	ribonuclease E activity
Tchl_2381	COG0564	pseudouridine synthase activity
Tchl_2382	COG0546	phosphoglycolate phosphatase activity
Tchl_2383	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tchl_2384	COG0424	maF-like protein
Tchl_2385	COG1399	metal-binding, possibly nucleic acid-binding protein
Tchl_2386	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tchl_2387	COG0416	fatty acid biosynthetic process
Tchl_2388	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tchl_2391	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tchl_2394	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tchl_2399	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tchl_2401	COG0481	GTPase activity
Tchl_2402	COG0681	Belongs to the peptidase S26 family
Tchl_2404	COG0571	ribonuclease III activity
Tchl_2405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tchl_2406	COG1381	Involved in DNA repair and RecF pathway recombination
Tchl_2407	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Tchl_2408	COG0736	holo-[acyl-carrier-protein] synthase activity
Tchl_2409	COG1472	Belongs to the glycosyl hydrolase 3 family
Tchl_2410	COG0322	excinuclease ABC activity
Tchl_2414	COG0501	Belongs to the peptidase M48B family
Tchl_2415	COG1704	LemA family
Tchl_2416	COG1242	4 iron, 4 sulfur cluster binding
Tchl_2428	COG4453	Protein conserved in bacteria
Tchl_2443	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tchl_2448	COG0789	Transcriptional regulator
Tchl_2464	COG2816	NAD+ diphosphatase activity
Tchl_2466	COG4771	TonB-dependent receptor
Tchl_2472	COG3437	response regulator, receiver
Tchl_2477	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tchl_2478	COG1469	GTP cyclohydrolase I activity
Tchl_2479	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tchl_2480	COG0142	geranyltranstransferase activity
Tchl_2481	COG1722	exodeoxyribonuclease VII activity
Tchl_2483	COG3411	Ferredoxin
Tchl_2484	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tchl_2485	COG1047	Peptidyl-prolyl cis-trans
Tchl_2486	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tchl_2487	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tchl_2488	COG0196	riboflavin kinase activity
Tchl_2490	COG0802	atpase or kinase
Tchl_2491	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tchl_2493	COG3045	CreA protein
Tchl_2494	COG3033	Beta-eliminating lyase
Tchl_2501	COG0826	peptidase U32
Tchl_2503	COG2133	pyrroloquinoline quinone binding
Tchl_2505	COG3108	Peptidase M15
Tchl_2506	COG2989	Protein conserved in bacteria
Tchl_2512	COG0697	spore germination
Tchl_2513	COG0488	(ABC) transporter
Tchl_2515	COG0583	DNA-binding transcription factor activity
Tchl_2517	COG0268	Binds directly to 16S ribosomal RNA
Tchl_2519	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tchl_2520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tchl_2521	COG0137	argininosuccinate synthase activity
Tchl_2523	COG3123	guanosine phosphorylase activity
Tchl_2524	COG1666	GTP binding
Tchl_2532	COG0494	nUDIX hydrolase
Tchl_2534	COG0183	Belongs to the thiolase family
Tchl_2535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tchl_2537	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tchl_2541	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_2543	COG5002	protein histidine kinase activity
Tchl_2544	COG0745	RESPONSE REGULATOR receiver
Tchl_2545	COG2176	DNA-directed DNA polymerase activity
Tchl_2545	COG5002	protein histidine kinase activity
Tchl_2546	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tchl_2548	COG0542	response to heat
Tchl_2553	COG0601	transmembrane transport
Tchl_2554	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tchl_2555	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Tchl_2559	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Tchl_2560	COG1140	nitrate reductase beta subunit
Tchl_2561	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Tchl_2562	COG2181	nitrate reductase activity
Tchl_2563	COG3850	Histidine kinase
Tchl_2564	COG2197	response regulator
Tchl_2567	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tchl_2569	COG2914	Belongs to the UPF0125 (RnfH) family
Tchl_2571	COG0519	Catalyzes the synthesis of GMP from XMP
Tchl_2571	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tchl_2576	COG4974	Belongs to the 'phage' integrase family
Tchl_2577	COG0582	viral genome integration into host DNA
Tchl_2578	COG4974	Belongs to the 'phage' integrase family
Tchl_2582	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tchl_2587	COG4680	protein conserved in bacteria
Tchl_2590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tchl_2590	COG1648	precorrin-2 dehydrogenase activity
Tchl_2591	COG2010	Cytochrome c
Tchl_2600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tchl_2606	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tchl_2610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tchl_2612	COG2010	Cytochrome c
Tchl_2614	COG0167	dihydroorotate dehydrogenase activity
Tchl_2615	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Tchl_2616	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Tchl_2617	COG3842	ATPase activity
Tchl_2618	COG1178	ABC-type Fe3 transport system permease component
Tchl_2619	COG1840	ABC-type Fe3 transport system, periplasmic component
Tchl_2621	COG0791	NLP P60 protein
Tchl_2624	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Tchl_2625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tchl_2627	COG0436	Aminotransferase
Tchl_2629	COG2258	MOSC domain
Tchl_2631	COG3360	Dodecin
Tchl_2633	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tchl_2635	COG0850	regulation of cytokinetic process
Tchl_2636	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tchl_2637	COG1393	Belongs to the ArsC family
Tchl_2638	COG2183	response to ionizing radiation
Tchl_2640	COG0045	succinate-CoA ligase (ADP-forming) activity
Tchl_2640	COG1042	CoA-binding domain protein
Tchl_2640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tchl_2642	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Tchl_2645	COG4181	ATPase activity
Tchl_2646	COG0560	Phosphoserine phosphatase
Tchl_2647	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tchl_2648	COG0519	Catalyzes the synthesis of GMP from XMP
Tchl_2652	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tchl_2654	COG2078	PFAM AMMECR1 domain protein
Tchl_2655	COG1355	regulation of microtubule-based process
Tchl_2656	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tchl_2657	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tchl_2658	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Tchl_2660	COG3228	Belongs to the MtfA family
Tchl_2661	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tchl_2662	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Tchl_2663	COG0248	Ppx GppA phosphatase
Tchl_2664	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tchl_2665	COG1127	ABC transporter
Tchl_2668	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_2669	COG0084	hydrolase, TatD family'
Tchl_2673	COG1960	acyl-CoA dehydrogenase activity
Tchl_2674	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tchl_2676	COG2350	Protein conserved in bacteria
Tchl_2677	COG2917	probably involved in intracellular septation
Tchl_2679	COG0745	RESPONSE REGULATOR receiver
Tchl_2681	COG1214	PFAM Peptidase M22, glycoprotease
Tchl_2683	COG1573	uracil-dna glycosylase
Tchl_2684	COG0477	Major facilitator Superfamily
Tchl_2687	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Tchl_2687	COG0512	Glutamine amidotransferase of anthranilate synthase
Tchl_2689	COG3259	Nickel-dependent hydrogenase
Tchl_2692	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tchl_2695	COG0628	permease
Tchl_2696	COG3162	membrane
Tchl_2700	COG3174	membrane
Tchl_2701	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tchl_2702	COG2814	Major facilitator Superfamily
Tchl_2704	COG5012	cobalamin binding
Tchl_2705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tchl_2721	COG2226	methyltransferase
Tchl_2723	COG1595	DNA-templated transcription, initiation
Tchl_2728	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Tchl_2729	COG0438	transferase activity, transferring glycosyl groups
Tchl_2730	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Tchl_2731	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Tchl_2732	COG3639	organic phosphonate transmembrane transporter activity
Tchl_2733	COG3639	organic phosphonate transmembrane transporter activity
Tchl_2741	COG1136	(ABC) transporter
Tchl_2742	COG0861	Integral membrane protein TerC family
Tchl_2743	COG1562	ergosterol biosynthetic process
Tchl_2744	COG1562	ergosterol biosynthetic process
Tchl_2745	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Tchl_2748	COG1702	phosphate starvation-inducible protein PhoH
Tchl_2749	COG2866	Carboxypeptidase
Tchl_2750	COG3022	response to hydroperoxide
Tchl_2753	COG0156	8-amino-7-oxononanoate synthase activity
Tchl_2754	COG2267	carboxylic ester hydrolase activity
Tchl_2755	COG2226	methyltransferase
Tchl_2756	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Tchl_2757	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tchl_2758	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tchl_2759	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tchl_2760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tchl_2761	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tchl_2762	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tchl_2766	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tchl_2767	COG0575	Belongs to the CDS family
Tchl_2768	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tchl_2769	COG0233	cytoplasmic translational termination
Tchl_2770	COG0528	UMP kinase activity
Tchl_2771	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tchl_2772	COG0052	Belongs to the universal ribosomal protein uS2 family
Tchl_2773	COG0024	Methionine aminopeptidase
Tchl_2774	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Tchl_2779	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tchl_2781	COG1196	nuclear chromosome segregation
Tchl_2782	COG0436	Aminotransferase
Tchl_2783	COG2171	N-acyltransferase activity
Tchl_2785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tchl_2789	COG0443	Heat shock 70 kDa protein
Tchl_2790	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Tchl_2792	COG0822	iron-sulfur transferase activity
Tchl_2793	COG1104	cysteine desulfurase activity
Tchl_2794	COG1104	cysteine desulfurase activity
Tchl_2796	COG1045	serine acetyltransferase
Tchl_2799	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tchl_2802	COG0517	IMP dehydrogenase activity
Tchl_2803	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tchl_2804	COG0328	RNA-DNA hybrid ribonuclease activity
Tchl_2805	COG2226	methyltransferase
Tchl_2842	COG4197	protein conserved in bacteria, prophage-related
Tchl_2847	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tchl_2855	COG1475	DNA binding
Tchl_2858	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tchl_2859	COG1388	LysM domain
Tchl_2859	COG0741	lytic transglycosylase activity
Tchl_2863	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tchl_2879	COG5002	protein histidine kinase activity
Tchl_2881	COG0789	Transcriptional regulator
Tchl_2896	COG0776	regulation of translation
Tchl_2897	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tchl_2898	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tchl_2899	COG0740	serine-type endopeptidase activity
Tchl_2900	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tchl_2901	COG2766	serine protein kinase
Tchl_2902	COG2718	Belongs to the UPF0229 family
Tchl_2903	COG2719	SpoVR family
Tchl_2904	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tchl_2904	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tchl_2907	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tchl_2909	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tchl_2910	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Tchl_2911	COG1674	ftsk spoiiie
Tchl_2913	COG0492	ferredoxin-NADP+ reductase activity
Tchl_2914	COG2840	Smr protein MutS2
Tchl_2915	COG0347	Belongs to the P(II) protein family
Tchl_2916	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tchl_2916	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tchl_2917	COG0494	nUDIX hydrolase
Tchl_2918	COG1007	ATP synthesis coupled electron transport
Tchl_2921	COG0713	ATP synthesis coupled electron transport
Tchl_2923	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tchl_2924	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tchl_2925	COG1034	ATP synthesis coupled electron transport
Tchl_2927	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tchl_2928	COG0649	NAD binding
Tchl_2929	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tchl_2930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tchl_2931	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tchl_2934	COG0149	triose-phosphate isomerase activity
Tchl_2936	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tchl_2939	COG0798	PFAM Bile acid sodium symporter
Tchl_2942	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tchl_2944	COG0573	inorganic phosphate transmembrane transporter activity
Tchl_2945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tchl_2946	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tchl_2947	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tchl_2948	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tchl_2949	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Tchl_2950	COG1534	Rna-binding protein
Tchl_2951	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tchl_2952	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tchl_2953	COG0505	Belongs to the CarA family
Tchl_2955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tchl_2957	COG0735	belongs to the Fur family
Tchl_2958	COG0497	DNA recombination
Tchl_2959	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tchl_2960	COG1420	regulation of RNA biosynthetic process
Tchl_2961	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Tchl_2962	COG0515	serine threonine protein kinase
Tchl_2962	COG2815	serine threonine protein kinase
Tchl_2963	COG0402	S-adenosylhomocysteine deaminase activity
Tchl_2964	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Tchl_2964	COG2885	chlorophyll binding
Tchl_2965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tchl_2966	COG1309	transcriptional regulator
Tchl_2967	COG1024	Enoyl-CoA hydratase
Tchl_2968	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_2969	COG1024	Enoyl-CoA hydratase
Tchl_2970	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_2971	COG1960	acyl-CoA dehydrogenase activity
Tchl_2973	COG1024	Enoyl-CoA hydratase
Tchl_2974	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_2976	COG0045	succinate-CoA ligase (ADP-forming) activity
Tchl_2976	COG1042	CoA-binding domain protein
Tchl_2976	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tchl_2978	COG1139	Iron-sulfur cluster binding protein
Tchl_2980	COG2186	Transcriptional regulator
Tchl_2981	COG2951	lytic endotransglycosylase activity
Tchl_2982	COG0584	glycerophosphoryl diester phosphodiesterase
Tchl_2985	COG2204	response regulator
Tchl_2990	COG0579	oxidoreductase
Tchl_2991	COG1454	alcohol dehydrogenase
Tchl_2993	COG1454	alcohol dehydrogenase
Tchl_2994	COG0410	ABC transporter
Tchl_2995	COG1137	ATPase activity
Tchl_2997	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tchl_3000	COG2204	response regulator
Tchl_3001	COG3852	Histidine kinase
Tchl_3004	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tchl_3005	COG1960	acyl-CoA dehydrogenase activity
Tchl_3006	COG0583	DNA-binding transcription factor activity
Tchl_3010	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tchl_3015	COG0582	viral genome integration into host DNA
Tchl_3029	COG4372	Transposase
Tchl_3035	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Tchl_3037	COG0686	Belongs to the AlaDH PNT family
Tchl_3041	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tchl_3043	COG0583	DNA-binding transcription factor activity
Tchl_3044	COG0583	DNA-binding transcription factor activity
Tchl_3045	COG0509	glycine decarboxylation via glycine cleavage system
Tchl_3046	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tchl_3046	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tchl_3048	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tchl_3051	COG4628	conserved protein (DUF2132)
Tchl_3061	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tchl_3068	COG4372	Transposase
Tchl_3070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tchl_3072	COG1881	PFAM PEBP family protein
Tchl_3073	COG2801	Transposase and inactivated derivatives
Tchl_3076	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tchl_3079	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tchl_3081	COG0163	prenyltransferase activity
Tchl_3083	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Tchl_3085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tchl_3089	COG0163	prenyltransferase activity
Tchl_3096	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_3097	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_3100	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Tchl_3101	COG2132	Multicopper oxidase
Tchl_3105	COG5002	protein histidine kinase activity
Tchl_3110	COG4628	conserved protein (DUF2132)
Tchl_3114	COG0251	oxidation-reduction process
Tchl_3115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tchl_3117	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_3118	COG0028	Belongs to the TPP enzyme family
Tchl_3120	COG0009	L-threonylcarbamoyladenylate synthase
Tchl_3121	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Tchl_3122	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tchl_3123	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tchl_3125	COG4566	intracellular signal transduction
Tchl_3128	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Tchl_3129	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tchl_3130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tchl_3134	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tchl_3134	COG0047	phosphoribosylformylglycinamidine synthase activity
Tchl_3135	COG4372	Transposase
Tchl_3143	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tchl_3144	COG0509	glycine decarboxylation via glycine cleavage system
Tchl_3145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tchl_3145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tchl_3147	COG1215	transferase activity, transferring glycosyl groups
Tchl_3148	COG0471	metal ion transport
Tchl_3150	COG0563	adenylate kinase activity
Tchl_3151	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Tchl_3152	COG2835	tetraacyldisaccharide 4'-kinase activity
Tchl_3153	COG1663	tetraacyldisaccharide 4'-kinase activity
Tchl_3154	COG0848	biopolymer transport protein
Tchl_3155	COG0811	peptide transport
Tchl_3156	COG1570	exodeoxyribonuclease VII activity
Tchl_3157	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tchl_3159	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tchl_3161	COG4657	Part of a membrane complex involved in electron transport
Tchl_3162	COG2878	Part of a membrane complex involved in electron transport
Tchl_3166	COG4660	Part of a membrane complex involved in electron transport
Tchl_3167	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tchl_3170	COG1280	lysine exporter protein (LysE YggA)
Tchl_3172	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Tchl_3173	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tchl_3173	COG2169	Transcriptional regulator
Tchl_3180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tchl_3183	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tchl_3190	COG0326	Molecular chaperone. Has ATPase activity
Tchl_3196	COG1230	cation diffusion facilitator family transporter
Tchl_3197	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tchl_3198	COG0643	Histidine kinase
Tchl_3198	COG2198	Histidine kinase
Tchl_3201	COG0840	transmembrane signaling receptor activity
Tchl_3204	COG2197	response regulator
Tchl_3206	COG0697	spore germination
Tchl_3207	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Tchl_3209	COG2217	Heavy metal translocating P-type atpase
Tchl_3212	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tchl_3213	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tchl_3214	COG3094	Invasion gene expression up-regulator, SirB
Tchl_3216	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tchl_3221	COG2010	Cytochrome c
Tchl_3224	COG3278	Belongs to the heme-copper respiratory oxidase family
Tchl_3226	COG2217	Heavy metal translocating P-type atpase
Tchl_3230	COG1346	cytolysis
Tchl_3235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tchl_3239	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Tchl_3240	COG1051	belongs to the nudix hydrolase family
Tchl_3241	COG0756	dUTP diphosphatase activity
Tchl_3242	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tchl_3243	COG2003	Belongs to the UPF0758 family
Tchl_3244	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tchl_3245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tchl_3246	COG1278	Cold shock
Tchl_3247	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tchl_3248	COG0542	response to heat
Tchl_3249	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tchl_3253	COG0745	RESPONSE REGULATOR receiver
Tchl_3257	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tchl_3258	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tchl_3259	COG0739	heme binding
Tchl_3260	COG0316	Belongs to the HesB IscA family
Tchl_3261	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tchl_3262	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tchl_3263	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tchl_3264	COG1765	OsmC-like protein
Tchl_3265	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Tchl_3268	COG0247	lactate metabolic process
Tchl_3269	COG1592	Rubrerythrin
Tchl_3270	COG0494	nUDIX hydrolase
Tchl_3271	COG0442	prolyl-tRNA aminoacylation
Tchl_3272	COG0741	lytic transglycosylase activity
Tchl_3274	COG2204	response regulator
Tchl_3276	COG0312	modulator of DNA gyrase
Tchl_3277	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tchl_3279	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Tchl_3284	COG0482	sulfurtransferase activity
Tchl_3292	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tchl_3295	COG2096	Adenosyltransferase
Tchl_3296	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tchl_3297	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tchl_3298	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Tchl_3299	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Tchl_3300	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Tchl_3301	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tchl_3302	COG3028	Belongs to the UPF0307 family
Tchl_3303	COG0312	modulator of DNA gyrase
Tchl_3304	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tchl_3305	COG0406	alpha-ribazole phosphatase activity
Tchl_3306	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tchl_3308	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tchl_3309	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tchl_3310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tchl_3311	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tchl_3311	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tchl_3312	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tchl_3314	COG0793	Belongs to the peptidase S41A family
Tchl_3316	COG0640	Transcriptional regulator
Tchl_3317	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tchl_3319	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Tchl_3321	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tchl_3322	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Tchl_3323	COG1040	competence protein
Tchl_3324	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tchl_3325	COG2226	methyltransferase
Tchl_3328	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tchl_3331	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Tchl_3333	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Tchl_3334	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Tchl_3334	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tchl_3336	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tchl_3337	COG0483	inositol monophosphate 1-phosphatase activity
Tchl_3338	COG3954	Phosphoribulokinase
Tchl_3340	COG0672	)-iron permease
Tchl_3344	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tchl_3345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tchl_3346	COG0126	phosphoglycerate kinase activity
Tchl_3353	COG0285	dihydrofolate synthase activity
Tchl_3354	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Tchl_3355	COG0159	tryptophan synthase activity
Tchl_3356	COG0133	tryptophan synthase activity
Tchl_3357	COG0135	phosphoribosylanthranilate isomerase activity
Tchl_3358	COG0101	tRNA pseudouridine synthase activity
Tchl_3362	COG0473	3-isopropylmalate dehydrogenase activity
Tchl_3363	COG0066	3-isopropylmalate dehydratase activity
Tchl_3365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tchl_3366	COG0501	Belongs to the peptidase M48B family
Tchl_3367	COG2814	Major facilitator Superfamily
Tchl_3368	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tchl_3369	COG0440	acetolactate synthase activity
Tchl_3370	COG0028	Belongs to the TPP enzyme family
Tchl_3371	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_3375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tchl_3376	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_3384	COG0277	FAD linked oxidase domain protein
Tchl_3385	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tchl_3386	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tchl_3387	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Tchl_3389	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_3390	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tchl_3393	COG0564	pseudouridine synthase activity
Tchl_3395	COG2814	Major facilitator Superfamily
Tchl_3396	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Tchl_3397	COG3383	formate dehydrogenase (NAD+) activity
Tchl_3399	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_3403	COG0411	ABC transporter
Tchl_3404	COG4177	L-phenylalanine transmembrane transporter activity
Tchl_3407	COG1024	Enoyl-CoA hydratase
Tchl_3409	COG1960	acyl-CoA dehydrogenase activity
Tchl_3413	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_3414	COG1960	acyl-CoA dehydrogenase activity
Tchl_3419	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_3420	COG1024	Enoyl-CoA hydratase
Tchl_3421	COG0183	Belongs to the thiolase family
Tchl_3431	COG4372	Transposase
Tchl_3433	COG1309	transcriptional regulator
Tchl_3437	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tchl_3438	COG0745	RESPONSE REGULATOR receiver
Tchl_3439	COG0642	Histidine kinase
Tchl_3441	COG0288	reversible hydration of carbon dioxide
Tchl_3444	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tchl_3445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tchl_3447	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tchl_3449	COG0569	domain protein
Tchl_3450	COG2204	response regulator
Tchl_3451	COG5000	phosphorelay sensor kinase activity
Tchl_3454	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tchl_3455	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Tchl_3457	COG2259	Doxx family
Tchl_3467	COG0582	viral genome integration into host DNA
Tchl_3468	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tchl_3469	COG0706	membrane insertase activity
Tchl_3470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tchl_3471	COG0594	ribonuclease P activity
Tchl_3472	COG0230	Belongs to the bacterial ribosomal protein bL34 family