locus-tag class description AC731_000020 ENOG4105E0F Histidine kinase AC731_000025 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AC731_000035 ENOG4108I9X Isocitrate lyase AC731_000040 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AC731_000045 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AC731_000050 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AC731_000055 ENOG4105VEQ Cold shock protein AC731_000060 ENOG4105W0E 50S ribosomal protein L33 AC731_000065 ENOG4105KDC 50s ribosomal protein l28 AC731_000070 ENOG4105W5Q DNA repair protein (RadC AC731_000075 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AC731_000080 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AC731_000095 ENOG4107S7U Sulfide dehydrogenase AC731_000105 ENOG4105KTU Transcriptional regulator, arsr family AC731_000110 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AC731_000115 ENOG4105W2Z cytochrome C, class I AC731_000150 ENOG4107QN1 sodium solute AC731_000165 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AC731_000190 ENOG4105DXC membrane AC731_000230 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AC731_000245 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) AC731_000270 ENOG4105CY0 Metallo-Beta-Lactamase AC731_000275 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AC731_000280 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AC731_000290 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AC731_000295 ENOG4105D4P Coproporphyrinogen iii oxidase AC731_000305 ENOG4105W1Y Transcriptional regulator AC731_000310 ENOG4105C59 p-type ATPase AC731_000320 ENOG4105F0N pyrophosphate phospho-hydrolase AC731_000325 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AC731_000330 ENOG4105BZU Histidine kinase AC731_000335 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AC731_000345 ENOG4108V3W Chemotaxis protein, CheW AC731_000355 ENOG4105CBS Chea signal transduction histidine kinase AC731_000370 ENOG4108VYJ response regulator receiver protein AC731_000375 ENOG4107QUY Guanine deaminase AC731_000390 ENOG4108NIW Leucine export protein LeuE AC731_000395 ENOG4105BZU Histidine kinase AC731_000400 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AC731_000405 ENOG4105BZU Histidine kinase AC731_000410 ENOG4105BZU Histidine kinase AC731_000420 ENOG4105UIB (ABC) transporter AC731_000425 ENOG4108JQ9 ABC transporter AC731_000430 ENOG4105C7W Xanthine dehydrogenase AC731_000460 ENOG4105PGM cation diffusion facilitator family transporter AC731_000465 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AC731_000470 ENOG4106WHD Tetrathionate reductase AC731_000475 ENOG4105DB1 molybdopterin oxidoreductase AC731_000485 ENOG4106AFQ Histidine kinase AC731_000510 ENOG4108RRZ Transcription elongation factor GreB AC731_000515 ENOG4105C8Q Methyl-accepting chemotaxis AC731_000520 ENOG4105C8Q Methyl-accepting chemotaxis AC731_000525 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AC731_000530 ENOG4105C0Z ABC transporter AC731_000535 ENOG4108IV0 ABC, transporter AC731_000545 ENOG4105C32 Amino acid ABC transporter (Permease) AC731_000570 ENOG4105C34 Pseudouridine synthase AC731_000575 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AC731_000585 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AC731_000590 ENOG4105CHR reductase AC731_000605 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) AC731_000610 ENOG4105D78 K07001 NTE family protein AC731_000615 ENOG4105CQB FAD linked oxidase domain protein AC731_000650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AC731_000655 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AC731_000660 ENOG4105K63 Thioredoxin AC731_000665 ENOG4108Z4U Ferredoxin AC731_000675 ENOG4105CEY Amp-dependent synthetase and ligase AC731_000680 ENOG4105C7K acetolactate synthase AC731_000685 ENOG4105M71 acetolactate synthase 1 regulatory subunit AC731_000690 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AC731_000695 ENOG4105D8G Major Facilitator superfamily AC731_000700 ENOG4108K0D peptidase, M48 AC731_000705 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AC731_000715 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AC731_000720 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AC731_000725 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AC731_000740 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AC731_000745 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AC731_000750 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AC731_000755 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AC731_000760 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AC731_000765 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AC731_000780 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AC731_000785 ENOG4105C28 cystathionine AC731_000790 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AC731_000795 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AC731_000800 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AC731_000805 ENOG4105C8N cysteinyl-tRNA synthetase AC731_000810 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AC731_000815 ENOG4105CFG Acts as a chaperone (By similarity) AC731_000820 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AC731_000830 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AC731_000835 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AC731_000845 ENOG4105CIH Imidazole acetol-phosphate transaminase AC731_000855 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AC731_000860 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AC731_000865 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AC731_000875 ENOG4105CFV Tetratricopeptide repeat protein AC731_000880 ENOG4105C6T cysteine synthase AC731_000905 ENOG4105Y3U Transglycosylase-associated protein AC731_000915 ENOG4105C22 threonyL-tRNA synthetase AC731_000920 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AC731_000925 ENOG4105VJV 50s ribosomal protein L35 AC731_000930 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AC731_000935 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AC731_000940 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AC731_000945 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AC731_000960 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AC731_000965 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AC731_000970 ENOG4108K5P (LipO)protein AC731_000975 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC731_000985 ENOG4105CVE Lytic murein transglycosylase AC731_000990 ENOG4105F8C transglutaminase domain-containing protein AC731_001000 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AC731_001010 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AC731_001015 ENOG4105GJM (LipO)protein AC731_001025 ENOG4105EZE Cupin 4 family protein AC731_001030 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AC731_001040 ENOG4108R99 pseudouridine synthase AC731_001050 ENOG4105D00 flagellar biosynthetic protein flhB AC731_001055 ENOG4105D7B Flagellar biosynthesis protein flha AC731_001060 ENOG4105FZW flagellar biosynthesis regulator FlhF AC731_001070 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC731_001075 ENOG4105E14 MotA TolQ exbB proton channel AC731_001080 ENOG4105ER2 Ompa motb domain protein AC731_001085 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AC731_001090 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AC731_001105 ENOG4105CKS Flagella basal body P-ring formation protein flgA AC731_001110 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AC731_001115 ENOG4108ZC9 flagellar basal-body rod protein flgc AC731_001120 ENOG4105W00 Flagellar hook capping protein AC731_001125 ENOG4105BZE flagellar hook protein, FlgE AC731_001130 ENOG4108KPB Flagellar basal-body rod protein FlgF AC731_001135 ENOG4105CGA flagellar basal-body rod protein FlgG AC731_001140 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AC731_001145 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AC731_001150 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AC731_001155 ENOG4105E1Q flagellar hook-associated protein AC731_001160 ENOG4105DTJ flagellar hook-associated protein AC731_001170 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AC731_001175 ENOG4105VS8 Flagellar biosynthetic protein fliq AC731_001180 ENOG4105CN7 Flagellar biosynthetic protein FliP AC731_001185 ENOG4105VTB flagellar biosynthesis protein fliO AC731_001190 ENOG4105DD5 Flagellar motor switch protein AC731_001195 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AC731_001215 ENOG4108JIR Flagellum-specific ATP synthase AC731_001225 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AC731_001230 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AC731_001235 ENOG4105BZU Histidine kinase AC731_001245 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AC731_001260 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) AC731_001265 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) AC731_001270 ENOG4105D00 flagellar biosynthetic protein flhB AC731_001285 ENOG4105MQ3 flagellar protein FliS AC731_001290 ENOG4105DTS flagellar hook-associated AC731_001295 ENOG41063QE flagellar protein FlaG AC731_001315 ENOG4105K64 Glycosyl transferase, family 2 AC731_001325 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AC731_001355 ENOG4108MTT Glutamate-rich protein grpB AC731_001360 ENOG4107QN2 dihydrolipoyl dehydrogenase AC731_001365 ENOG4107QSN dihydrolipoamide acetyltransferase AC731_001370 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AC731_001380 ENOG4105BZU Histidine kinase AC731_001385 ENOG4108ZXC Two component transcriptional regulator, luxr family AC731_001390 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AC731_001395 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AC731_001400 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AC731_001405 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AC731_001410 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AC731_001435 ENOG4108C33 Resolvase AC731_001485 ENOG4107XZC Restriction modification system DNA (Specificity AC731_001490 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AC731_001515 ENOG4105EUB pirin domain protein AC731_001520 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AC731_001530 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AC731_001545 ENOG4105CYM Glutathione S-transferase AC731_001565 ENOG4108ETT Dehydrogenase AC731_001575 ENOG4105XJC Two component transcriptional regulator (Winged helix family AC731_001580 ENOG4105DHQ Histidine kinase AC731_001595 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase AC731_001600 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AC731_001605 ENOG4105UGU tonB-dependent Receptor AC731_001615 ENOG4108K3A Glutathione S-transferase AC731_001645 ENOG4105BZU Histidine kinase AC731_001670 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AC731_001675 ENOG4105HDK L-asparaginase AC731_001680 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_001690 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AC731_001700 ENOG4105EJC lysr family transcriptional regulator AC731_001720 ENOG4105C4R Atp-dependent dna helicase AC731_001740 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AC731_001745 ENOG4105BZU Histidine kinase AC731_001815 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) AC731_001820 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) AC731_001850 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AC731_001865 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AC731_001870 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AC731_001875 ENOG4105BZ7 extracellular solute-binding protein family 1 AC731_001880 ENOG4108IJ9 (ABC) transporter AC731_001885 ENOG4105E98 transcriptional regulator DeoR family AC731_001890 ENOG4105BZF Glycosyl transferase (Group 1 AC731_001900 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AC731_001910 ENOG4107T6V glycerophosphoryl diester phosphodiesterase AC731_001925 ENOG4105CVE Lytic murein transglycosylase AC731_001930 ENOG41073TP transcriptional regulator AC731_001935 ENOG4105DAA L-lactate AC731_001940 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AC731_001945 ENOG4107QR9 Iron-sulfur cluster binding protein AC731_001950 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AC731_001960 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AC731_001965 ENOG4105UYK outer membrane protein a AC731_001970 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AC731_001975 ENOG4105D9P serine threonine protein kinase AC731_001980 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AC731_001985 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AC731_001990 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AC731_001995 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AC731_002000 ENOG41090R7 Ferric uptake AC731_002005 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AC731_002010 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AC731_002015 ENOG4105BZU Histidine kinase AC731_002020 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AC731_002025 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AC731_002030 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AC731_002035 ENOG4105HBR Rna-binding protein AC731_002040 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AC731_002045 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AC731_002050 ENOG4105EEI dihydropteroate synthase AC731_002055 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AC731_002060 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AC731_002065 ENOG4105C8U phosphate abc transporter AC731_002070 ENOG4105E2Z phosphate ABC transporter (Permease AC731_002075 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AC731_002080 ENOG4105CP7 Triose-phosphate isomerase AC731_002085 ENOG4107EJC Preprotein translocase subunit SecG AC731_002095 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AC731_002100 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AC731_002105 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AC731_002110 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AC731_002115 ENOG4105GKE subunit e AC731_002125 ENOG4108IEH NADH dehydrogenase subunit g AC731_002130 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AC731_002135 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AC731_002140 ENOG4105DF2 NADH dehydrogenase subunit j AC731_002145 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AC731_002155 ENOG4105C8S subunit m AC731_002160 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AC731_002180 ENOG4105C4K Nad synthetase AC731_002185 ENOG4108YZA Nitrogen regulatory protein pii AC731_002190 ENOG4108DG9 Smr protein MutS2 AC731_002195 ENOG4105C3M thioredoxin reductase AC731_002200 ENOG4107RYR Transcriptional regulator, Crp Fnr family AC731_002205 ENOG4105CNU cell division protein FtsK AC731_002210 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AC731_002215 ENOG4105D1H recombination factor protein RarA AC731_002225 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AC731_002230 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AC731_002235 ENOG4106T14 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AC731_002260 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) AC731_002265 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AC731_002270 ENOG4105CTB Polyprenyl synthetase AC731_002275 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AC731_002285 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AC731_002290 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AC731_002295 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AC731_002300 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AC731_002305 ENOG4105DTN riboflavin biosynthesis protein ribF AC731_002310 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AC731_002315 ENOG4105K8N protein family UPF0079, ATPase AC731_002320 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AC731_002330 ENOG4105F64 nitrite reductase AC731_002350 ENOG4108RH0 Crea protein AC731_002360 ENOG4105CJW magnesium transporter AC731_002370 ENOG4105CFP Peptidase U32 AC731_002385 ENOG4105D9P serine threonine protein kinase AC731_002390 ENOG41080IJ Diacylglycerol kinase AC731_002395 ENOG4105EAQ (twin-arginine translocation) pathway signal AC731_002400 ENOG4105DIT ErfK YbiS YcfS YnhG family protein AC731_002435 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AC731_002445 ENOG41085FC arsR family transcriptional regulator AC731_002455 ENOG4105D6J arsenicaL-resistance protein AC731_002480 ENOG4105F8J Adenylate Guanylate cyclase AC731_002520 ENOG4107SDU Methyl-accepting chemotaxis AC731_002530 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) AC731_002540 ENOG4108N3W hemolysin secretion protein AC731_002545 ENOG4105E2Y ABC, transporter AC731_002550 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AC731_002555 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AC731_002560 ENOG4105GVF (ABC) transporter AC731_002570 ENOG4107S7U Sulfide dehydrogenase AC731_002620 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AC731_002625 ENOG4108UZX fmn reductase AC731_002635 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AC731_002640 ENOG4105GVF (ABC) transporter AC731_002645 ENOG4108UMI ABC transporter, permease AC731_002650 ENOG4105D01 (LipO)protein AC731_002655 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AC731_002660 ENOG4105D01 (LipO)protein AC731_002665 ENOG4108J2R molybdopterin oxidoreductase AC731_002705 ENOG4107T8P acyl-Coa dehydrogenase AC731_002710 ENOG4107SM7 Transcriptional regulator AC731_002755 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AC731_002775 ENOG4105FQT AC731_002790 ENOG4105CXY transporter AC731_002795 ENOG4105CBX hi0933 family AC731_002820 ENOG4108UNV SUF system FeS assembly protein, NifU family AC731_002825 ENOG4105C9B Cysteine desulfurase AC731_002830 ENOG4105JRK feS assembly protein SufD AC731_002835 ENOG4105C3K feS assembly ATPase SufC AC731_002860 ENOG4105M08 Membrane AC731_002865 ENOG4105C3S Mate efflux family protein AC731_002870 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AC731_002880 ENOG4105DR4 Methyltransferase AC731_002905 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AC731_002930 ENOG4105BZU Histidine kinase AC731_002935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AC731_002940 ENOG4108I6A alcohol dehydrogenase AC731_002945 ENOG4108WUH Transcriptional regulator, TetR family AC731_002950 ENOG4105DXI Major Facilitator superfamily AC731_002955 ENOG4105CMI transporter AC731_002960 ENOG4105CJ1 ABC, transporter AC731_002965 ENOG4105D0S secretion protein (HlyD AC731_002975 ENOG4105DHJ ABC, transporter AC731_002990 ENOG4105C0B DNA polymerase III (alpha subunit) AC731_003000 ENOG4105C7J ABC transporter, permease AC731_003005 ENOG4105D5T phosphonate abc transporter AC731_003010 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AC731_003020 ENOG4105WH1 Two component transcriptional regulator luxr family AC731_003030 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AC731_003035 ENOG4105CKW Inner membrane protein yedI AC731_003040 ENOG4105CRK lysyL-tRNA synthetase AC731_003045 ENOG4105C8Q Methyl-accepting chemotaxis AC731_003055 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AC731_003070 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AC731_003075 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AC731_003100 ENOG4105VEQ Cold shock protein AC731_003105 ENOG4105CCT upf0313 protein AC731_003110 ENOG4105BZU Histidine kinase AC731_003115 ENOG4105D60 lipoprotein releasing system transmembrane protein AC731_003120 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AC731_003130 ENOG4107SDU Methyl-accepting chemotaxis AC731_003140 ENOG4108EC8 DNA internalization-related competence protein ComEC AC731_003160 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AC731_003165 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AC731_003175 ENOG4105VFB Binds the 23S rRNA (By similarity) AC731_003180 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AC731_003185 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AC731_003190 ENOG4106RHG Yeca family AC731_003195 ENOG4105PI0 Ferredoxin AC731_003220 ENOG4105K5B UPF0225 protein AC731_003225 ENOG4107QIJ Aconitate hydratase 2 AC731_003230 ENOG4105BZU Histidine kinase AC731_003235 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AC731_003240 ENOG4105DEN Luciferase family AC731_003250 ENOG4106PMH Extracellular solute-binding protein family 3 AC731_003255 ENOG4105DSP amino acid AbC transporter AC731_003260 ENOG4106YG3 ABC transporter AC731_003265 ENOG4108JEH abc transporter atp-binding protein AC731_003270 ENOG4105D94 Major Facilitator Superfamily AC731_003275 ENOG4106NZI LysR family Transcriptional regulator AC731_003285 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AC731_003290 ENOG4105FDP GntR family transcriptional regulator AC731_003310 ENOG4105E33 succinate dehydrogenase AC731_003315 ENOG4105Y75 tpr repeat protein AC731_003320 ENOG4105BZN citrate synthase AC731_003325 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AC731_003330 ENOG4105C7S Dehydrogenase AC731_003335 ENOG4107QN2 dihydrolipoyl dehydrogenase AC731_003340 ENOG4105D6Z AFG1 family ATPase AC731_003365 ENOG4108WWZ General secretion pathway protein J AC731_003370 ENOG4105X5Z General secretion pathway protein I AC731_003380 ENOG4108VAU general secretion pathway protein G AC731_003385 ENOG4105D7Q type ii secretion system AC731_003390 ENOG4107QHF type ii secretion system protein e AC731_003395 ENOG4105GVR general secretion pathway protein D AC731_003405 ENOG4105DVT helicase AC731_003415 ENOG4108QDE fad dependent oxidoreductase AC731_003420 ENOG4105CVP deoxyribo-dipyrimidine photolyase AC731_003425 ENOG4105CVP deoxyribo-dipyrimidine photolyase AC731_003505 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) AC731_003555 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AC731_003680 ENOG4108C33 Resolvase AC731_003695 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AC731_003700 ENOG4105CVM Molybdenum cofactor synthesis domain protein AC731_003705 ENOG4105M00 molybdopterin converting factor, subunit 1 AC731_003710 ENOG4108ZAF Molybdopterin AC731_003725 ENOG4105HA9 of methanol dehydrogenase type AC731_003730 ENOG4108V0P LemA family AC731_003745 ENOG4105CSR polyphosphate kinase 2 AC731_003750 ENOG4107SDU Methyl-accepting chemotaxis AC731_003765 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AC731_003770 ENOG4108Z6B deaminase AC731_003775 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein AC731_003785 ENOG4105I7M spermidine synthase AC731_003800 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AC731_003805 ENOG4105HHA aminodeoxychorismate lyase AC731_003810 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AC731_003815 ENOG4107QRG dna polymerase iii AC731_003825 ENOG4105F8V Hydrolase, tatD family AC731_003835 ENOG4105C1J atp-dependent rna helicase AC731_003840 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AC731_003850 ENOG4105DGU Histone deacetylase AC731_003855 ENOG4105CJR Integral membrane protein (MviN AC731_003860 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) AC731_003870 ENOG4105C8Y Acetylornithine aminotransferase AC731_003875 ENOG4105DBV ornithine carbamoyltransferase AC731_003880 ENOG4105CDH Citrulline--aspartate ligase AC731_003890 ENOG4105NBK UPF0345 protein AC731_003895 ENOG4108VPT UPF0234 protein AC731_003935 ENOG4105CWU Biogenesis protein AC731_003955 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AC731_003960 ENOG4105CHU acetyl-coa acetyltransferase AC731_003965 ENOG4105E0X reductase AC731_003975 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AC731_003980 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AC731_003985 ENOG4107GFK fumarate AC731_003990 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AC731_004000 ENOG4105BZU Histidine kinase AC731_004005 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AC731_004010 ENOG4108IRC dna polymerase iii AC731_004015 ENOG4107QN1 sodium solute AC731_004020 ENOG4105BZU Histidine kinase AC731_004025 ENOG4105BZU Histidine kinase AC731_004030 ENOG410904N short-chain dehydrogenase reductase AC731_004035 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AC731_004040 ENOG4105BZU Histidine kinase AC731_004045 ENOG4105EIN peptidylprolyl cis-trans isomerase AC731_004050 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AC731_004065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AC731_004070 ENOG4105CNG UPF0061 protein AC731_004075 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AC731_004085 ENOG4105VDB UPF0125 protein AC731_004095 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AC731_004100 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AC731_004125 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase AC731_004135 ENOG4105DIJ Phosphoethanolamine transferase AC731_004140 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AC731_004145 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AC731_004150 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AC731_004155 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AC731_004160 ENOG4108IUM Glycogen debranching enzyme AC731_004165 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AC731_004170 ENOG4107QP8 phosphohexose isomerase AC731_004175 ENOG4105CHC glucokinase (EC 2.7.1.2) AC731_004200 ENOG4107SDU Methyl-accepting chemotaxis AC731_004215 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AC731_004230 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AC731_004235 ENOG4105DDY UPF0142 protein ycaO AC731_004240 ENOG4108KWP DNA-binding transcriptional regulator GlcC AC731_004245 ENOG4105CQB FAD linked oxidase domain protein AC731_004250 ENOG4105EU8 FAD linked oxidase domain protein AC731_004255 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AC731_004260 ENOG4108ZJF Glcg protein AC731_004265 ENOG4105DAA L-lactate AC731_004285 ENOG4105BZU Histidine kinase AC731_004290 ENOG4105CHF Glutathione S-transferase AC731_004295 ENOG4105HEI LysR family (Transcriptional regulator AC731_004300 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AC731_004305 ENOG4106KED esterase YpfH AC731_004380 ENOG4108KU3 Integrase AC731_004385 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AC731_004390 ENOG4107QMS site-determining protein AC731_004395 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AC731_004400 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AC731_004405 ENOG4105KUZ arsenate reductase AC731_004410 ENOG4105BZM domain protein AC731_004420 ENOG4105CD5 CoA-binding domain protein AC731_004425 ENOG4105BZU Histidine kinase AC731_004435 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) AC731_004445 ENOG4108UJV acyl-CoA thioesterase i AC731_004450 ENOG4108I0Y (ABC) transporter AC731_004455 ENOG4105EAC phosphoserine phosphatase AC731_004460 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AC731_004465 ENOG4105D7N magnesium and cobalt transport protein CorA AC731_004470 ENOG4108JA2 transcriptioN-repair coupling factor AC731_004495 ENOG4105NBF ammecr1 domain protein AC731_004500 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein AC731_004505 ENOG4107PU6 Membrane AC731_004510 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AC731_004515 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AC731_004530 ENOG4105CS1 NAD(P)H quinone oxidoreductase AC731_004540 ENOG4108IPJ Membrane AC731_004545 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AC731_004550 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AC731_004555 ENOG4105C9X ppx gppa phosphatase AC731_004565 ENOG4105DHJ ABC, transporter AC731_004585 ENOG4105EYA deoxyribonuclease AC731_004590 ENOG4108IG5 Transcriptional regulator AC731_004595 ENOG4105BZJ Electron transfer flavoprotein AC731_004600 ENOG4105C10 Electron transfer flavoprotein AC731_004610 ENOG4105CSU acyl-Coa dehydrogenase AC731_004615 ENOG4107TF3 peptidylprolyl cis-trans isomerase AC731_004625 ENOG4105K9H YciI-like protein AC731_004630 ENOG4107835 probably involved in intracellular septation (By similarity) AC731_004640 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AC731_004645 ENOG4105E0F Histidine kinase AC731_004650 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AC731_004655 ENOG41072GX Peptidase M22 Glycoprotease AC731_004665 ENOG4108UN4 phage SPO1 DNA polymerase-related protein AC731_004670 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AC731_004675 ENOG4105DND Transcriptional regulator AC731_004680 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AC731_004685 ENOG4105CHB tonB-dependent Receptor AC731_004700 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) AC731_004705 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) AC731_004710 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d AC731_004715 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E AC731_004720 ENOG4105WH1 Two component transcriptional regulator luxr family AC731_004725 ENOG4105BZU Histidine kinase AC731_004750 ENOG4105CJ1 ABC, transporter AC731_004775 ENOG4105BZU Histidine kinase AC731_004810 ENOG4108DY6 Extracellular solute-binding protein family 3 AC731_004820 ENOG4105DZG Dehydrogenase AC731_004840 ENOG4108M6X Dehydrogenase AC731_004845 ENOG41068T5 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT (By similarity) AC731_004850 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AC731_004855 ENOG4108P4C Formaldehyde-activating enzyme AC731_004910 ENOG4105DCC Formylmethanofuran dehydrogenase subunit A AC731_004915 ENOG4105FIE Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) (By similarity) AC731_004945 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AC731_004955 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AC731_004970 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AC731_004975 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AC731_005000 ENOG4105FE1 phytoene synthase AC731_005005 ENOG4105FE1 phytoene synthase AC731_005010 ENOG4107S11 squalene-associated FAD-dependent desaturase AC731_005020 ENOG4105D1Q UPF0246 protein AC731_005035 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AC731_005040 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AC731_005045 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AC731_005050 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AC731_005055 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AC731_005065 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AC731_005070 ENOG4105DZP Membrane-associated zinc metalloprotease AC731_005075 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AC731_005080 ENOG4105KNE Phosphatidate cytidylyltransferase AC731_005085 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AC731_005090 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AC731_005095 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AC731_005100 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AC731_005105 ENOG4105CE9 30S ribosomal protein S2 AC731_005110 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AC731_005115 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AC731_005120 ENOG4108TEB UPF0114 protein AC731_005125 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) AC731_005135 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AC731_005140 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AC731_005150 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AC731_005155 ENOG4105CHM Aminotransferase AC731_005160 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) AC731_005165 ENOG4105CZX twitching motility protein AC731_005170 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AC731_005180 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AC731_005185 ENOG4105WVQ Fe-S assembly protein IscX AC731_005190 ENOG4108ZIT Ferredoxin, 2FE-2S AC731_005195 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AC731_005200 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) AC731_005210 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AC731_005215 ENOG4105C3J Cysteine desulfurase AC731_005220 ENOG4107QI6 Cysteine desulfurase AC731_005225 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AC731_005230 ENOG4105D7W serine acetyltransferase AC731_005240 ENOG4105ECY inositol monophosphatase AC731_005420 ENOG4108N0N Phage Terminase Large Subunit AC731_005515 ENOG4105DH7 May be involved in recombination (By similarity) AC731_005520 ENOG4107WZZ SMC domain protein AC731_005565 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AC731_005580 ENOG4105W87 Cbs domain AC731_005585 ENOG4108JDX DNA polymerase iii, epsilon subunit AC731_005590 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AC731_005600 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AC731_005605 ENOG4105WH1 Two component transcriptional regulator luxr family AC731_005610 ENOG4105E9H Lytic Murein transglycosylase AC731_005620 ENOG4108YZY peptidylprolyl cis-trans isomerase AC731_005635 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AC731_005655 ENOG4107QI1 Mate efflux family protein AC731_005675 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AC731_005680 ENOG4105QNF Outer membrane lipoprotein AC731_005685 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) AC731_005700 ENOG4105CUW cytochrome C-TYPE protein AC731_005705 ENOG4108J2R molybdopterin oxidoreductase AC731_005735 ENOG4108MEJ flavin reductase domain protein AC731_005740 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AC731_005750 ENOG4105BZU Histidine kinase AC731_005810 ENOG4105DKK Benzoate AC731_005815 ENOG4105E0C molybdate abc transporter AC731_005820 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AC731_005825 ENOG4105F4R Transcriptional regulator mode AC731_005830 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AC731_005840 ENOG4105DU1 integral membrane protein, terc AC731_005845 ENOG4105E3J oxidoreductase AC731_005855 ENOG4105VBA Cytochrome AC731_005875 ENOG4105XJC Two component transcriptional regulator (Winged helix family AC731_005880 ENOG4105BZU Histidine kinase AC731_005885 ENOG4105DIJ Phosphoethanolamine transferase AC731_005940 ENOG4107YR5 Diacylglycerol kinase AC731_005945 ENOG410841Q phosphoesterase PA-phosphatase related protein AC731_005950 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AC731_005960 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AC731_005970 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AC731_006060 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AC731_006065 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AC731_006070 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AC731_006075 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AC731_006080 ENOG4105CYN Serine protein kinase AC731_006085 ENOG4106AKX UPF0229 protein AC731_006090 ENOG4105ED1 spovr family AC731_006095 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AC731_006105 ENOG4107Y9U Membrane AC731_006110 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AC731_006130 ENOG4105WKW Pfam:DUF1458 AC731_006135 ENOG4108RPX mosc domain containing protein AC731_006140 ENOG4105D6E homoserine dehydrogenase AC731_006145 ENOG4105CHM Aminotransferase AC731_006155 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AC731_006160 ENOG4108IAB Phoh family AC731_006175 ENOG4105K4H Nlp p60 protein AC731_006190 ENOG4105BZU Histidine kinase AC731_006195 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component AC731_006200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AC731_006205 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AC731_006210 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate AC731_006215 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AC731_006230 ENOG4108VKQ nitriC oxide reductase AC731_006235 ENOG4105DSQ Nitric oxide reductase AC731_006240 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AC731_006245 ENOG4105BZU Histidine kinase AC731_006260 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AC731_006275 ENOG4105FAE von Willebrand factor, type A AC731_006285 ENOG4107SDU Methyl-accepting chemotaxis AC731_006290 ENOG4105BZU Histidine kinase AC731_006315 ENOG4108UMR transcriptional regulator AsnC family AC731_006335 ENOG4105Y7H Cytochrome AC731_006340 ENOG4105H0N Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I AC731_006350 ENOG4105CUW cytochrome C-TYPE protein AC731_006525 ENOG4108N0N Phage Terminase Large Subunit AC731_006575 ENOG4105RDA repressor AC731_006625 ENOG4105DH7 May be involved in recombination (By similarity) AC731_006630 ENOG4107WZZ SMC domain protein AC731_006695 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AC731_006700 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AC731_006705 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AC731_006710 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AC731_006715 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AC731_006720 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AC731_006725 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AC731_006735 ENOG4105C3F Signal peptidase i AC731_006740 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AC731_006750 ENOG4105C0H protease AC731_006760 ENOG4105VQK sigma E regulatory protein, MucB RseB AC731_006770 ENOG4105EMN RNA polymerase sigma factor AC731_006775 ENOG4108IYU L-aspartate oxidase AC731_006785 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AC731_006790 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AC731_006795 ENOG4105CHR reductase AC731_006800 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AC731_006805 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AC731_006810 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AC731_006815 ENOG4105VGS 50s ribosomal protein l32 AC731_006825 ENOG4108UHJ MAF-like protein AC731_006830 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AC731_006840 ENOG4105EI2 Pseudouridine synthase AC731_006845 ENOG4105C03 ribonuclease AC731_006855 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AC731_006860 ENOG4105CGF Aromatic amino acid aminotransferase AC731_006880 ENOG4105BZU Histidine kinase AC731_006885 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AC731_006895 ENOG4108R5S membrane AC731_006905 ENOG4105DAN ATP-dependent protease AC731_006910 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AC731_006935 ENOG4107STW synthase AC731_006955 ENOG4105K70 DNA-binding protein AC731_007100 ENOG4105CF2 Mu-like prophage FluMu protein GP28 AC731_007220 ENOG4105WCJ ec 1.1.1.193 AC731_007225 ENOG4107QJN gtp cyclohydrolase ii AC731_007245 ENOG4105CZN Potassium uptake protein AC731_007250 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AC731_007255 ENOG4105RD8 TRAP dicarboxylate transporter AC731_007270 ENOG4105DDW LysR family Transcriptional regulator AC731_007285 ENOG4105CV6 ABC transporter, permease AC731_007290 ENOG4105CH2 amidohydrolase AC731_007295 ENOG4105DUM transcriptional regulator, lysR family AC731_007300 ENOG4105DP0 ferredoxin-NADP reductase AC731_007305 ENOG4108V06 Glutathione peroxidase AC731_007310 ENOG4105C5H ABC transporter AC731_007325 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AC731_007330 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AC731_007335 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AC731_007340 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AC731_007345 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AC731_007350 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AC731_007355 ENOG4105CHV Transcription elongation factor NusA AC731_007360 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AC731_007365 ENOG4105FE9 pseudouridine synthase AC731_007370 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AC731_007375 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AC731_007380 ENOG4108Z4T Peptidase M50 AC731_007385 ENOG4107RTD sua5 ycio yrdc ywlc family protein AC731_007390 ENOG4105DB7 PHP domain protein AC731_007395 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AC731_007405 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AC731_007410 ENOG4105VEQ Cold shock protein AC731_007425 ENOG4105BZU Histidine kinase AC731_007435 ENOG4108VWS Yaeq family AC731_007450 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AC731_007460 ENOG4105EUJ GTP cyclohydrolase i AC731_007470 ENOG4105CJ3 phosphate transporter AC731_007480 ENOG4105D6S protein involved in catabolism of external DNA AC731_007485 ENOG4108Z0R Transferase AC731_007505 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AC731_007510 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AC731_007515 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AC731_007520 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AC731_007530 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AC731_007535 ENOG41082UD thioesterase Superfamily protein AC731_007540 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AC731_007560 ENOG4105BZU Histidine kinase AC731_007565 ENOG4105DHT Metal Dependent Phosphohydrolase AC731_007570 ENOG4107QIK phosphoribosylformylglycinamidine synthase AC731_007580 ENOG4105F5W AtP-binding protein AC731_007585 ENOG4106IJN integrase catalytic domain-containing protein AC731_007620 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AC731_007625 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AC731_007630 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AC731_007640 ENOG4107QZ7 Cellulose synthase catalytic subunit AC731_007645 ENOG4105C8P )-transporter AC731_007655 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AC731_007660 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AC731_007665 ENOG4105W49 UPF0434 protein AC731_007670 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AC731_007675 ENOG4109015 Biopolymer transport protein exbD tolR AC731_007685 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AC731_007690 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AC731_007695 ENOG4105DR9 pseudouridine synthase AC731_007700 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AC731_007705 ENOG4105CBS Chea signal transduction histidine kinase AC731_007710 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AC731_007715 ENOG4108VYJ response regulator receiver protein AC731_007720 ENOG4107R88 Chemotaxis protein (CheV) AC731_007725 ENOG4107R88 Chemotaxis protein (CheV) AC731_007735 ENOG4107RD7 Flagellar Motor Protein, MotA AC731_007740 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region AC731_007745 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) AC731_007750 ENOG4105BZU Histidine kinase AC731_007760 ENOG4105DGN Electron transport complex AC731_007765 ENOG4108R3D Electron transport complex AC731_007770 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) AC731_007780 ENOG4108UQQ Electron transport complex AC731_007790 ENOG4105CSM endonuclease III AC731_007805 ENOG4105XJC Two component transcriptional regulator (Winged helix family AC731_007825 ENOG4105E3J oxidoreductase AC731_007835 ENOG4108IJF Heavy metal efflux pump, CzcA AC731_007840 ENOG4105EP1 Efflux transporter rnd family, mfp subunit AC731_007860 ENOG4105GR3 Histidine kinase AC731_007870 ENOG4105D03 DNA-3-methyladenine glycosylase II AC731_007875 ENOG4105EVD ribosomal RNA large subunit methyltransferase N AC731_007880 ENOG4106RE7 Cytochrome AC731_007885 ENOG4105N7H Cytochrome AC731_007890 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AC731_007905 ENOG4105C2C drug resistance transporter, Bcr CflA AC731_007920 ENOG4105BZU Histidine kinase AC731_007925 ENOG4107QP3 malate synthase g AC731_007930 ENOG4108JB9 formate dehydrogenase AC731_007945 ENOG4105G2Y Transcriptional regulator AC731_007950 ENOG4105QPS Monooxygenase AC731_007960 ENOG4108ERU trap dicarboxylate transporter subunit DctP AC731_007965 ENOG4105DER m42 family AC731_007970 ENOG4108DIG cyanophycin synthetase AC731_007985 ENOG4105DHI Methyltransferase AC731_007990 ENOG4105BZU Histidine kinase AC731_007995 ENOG4105BZU Histidine kinase AC731_008000 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AC731_008005 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AC731_008010 ENOG4105W8H transhydrogenase (subunit alpha AC731_008015 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AC731_008020 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AC731_008025 ENOG4108R85 Short chain dehydrogenase AC731_008030 ENOG4108QIU Dehydrogenase AC731_008035 ENOG41080BE Methyl-accepting chemotaxis sensory transducer AC731_008045 ENOG4105C10 Electron transfer flavoprotein AC731_008050 ENOG4105BZJ Electron transfer flavoprotein AC731_008060 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AC731_008075 ENOG4108KC1 acyl-Coa dehydrogenase AC731_008090 ENOG4108UQN AraC family transcriptional regulator AC731_008095 ENOG4105C5I Dehydrogenase AC731_008110 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AC731_008115 ENOG4105CHU acetyl-coa acetyltransferase AC731_008120 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AC731_008130 ENOG4105D2B acyl-CoA dehydrogenase AC731_008135 ENOG410846T CoA-transferase family III AC731_008140 ENOG41080W3 amp-dependent synthetase and ligase AC731_008145 ENOG41090B9 response to stress AC731_008150 ENOG4105D6U Sodium Glutamate Symporter AC731_008155 ENOG41088SP formiminoglutamate hydrolase AC731_008170 ENOG4105D25 secreted protein AC731_008175 ENOG4105CEY Amp-dependent synthetase and ligase AC731_008180 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AC731_008195 ENOG4107RGH Aldehyde dehydrogenase AC731_008205 ENOG4108TKH Nitroreductase AC731_008225 ENOG4107Z3H Transcriptional regulator, TetR family AC731_008230 ENOG4105CHR reductase AC731_008235 ENOG4105J5T Amp-dependent synthetase and ligase AC731_008245 ENOG4105C4X radical SAM domain protein AC731_008250 ENOG4105ENH Sulfatase AC731_008255 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AC731_008275 ENOG4107QVM von Willebrand factor, type A AC731_008300 ENOG4105CC9 acyl-Coa dehydrogenase AC731_008305 ENOG4105D2B acyl-CoA dehydrogenase AC731_008310 ENOG4105CHU acetyl-coa acetyltransferase AC731_008320 ENOG4105CHR reductase AC731_008340 ENOG4105VT2 5-hydroxyisourate hydrolase AC731_008360 ENOG4105DHG Allantoate amidinohydrolase AC731_008370 ENOG4105MP9 class II Aldolase AC731_008375 ENOG41084KP 4-oxalocrotonate tautomerase AC731_008380 ENOG4105C2W permease AC731_008390 ENOG4108ZXC Two component transcriptional regulator, luxr family AC731_008400 ENOG4108Q5Y Membrane AC731_008405 ENOG4105EJC lysr family transcriptional regulator AC731_008415 ENOG41060W2 glyoxylate carboligase AC731_008420 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AC731_008425 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AC731_008440 ENOG4108ZJF Glcg protein AC731_008445 ENOG4105CA9 Pyruvate kinase AC731_008460 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AC731_008475 ENOG4105F2C Acetyl-CoA acetyltransferase AC731_008480 ENOG4105C1G acyl-Coa dehydrogenase AC731_008485 ENOG4105CC9 acyl-Coa dehydrogenase AC731_008530 ENOG4107QX3 carboxylase AC731_008580 ENOG4105CHR reductase AC731_008585 ENOG4105DNH Major Facilitator AC731_008595 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AC731_008620 ENOG410904A RNA polymerase AC731_008625 ENOG4105CAU Arsenical resistance protein, ArsH AC731_008650 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) AC731_008655 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase AC731_008660 ENOG4105YV1 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) AC731_008670 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AC731_008680 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AC731_008700 ENOG4108KEZ Dehydrogenase AC731_008705 ENOG4105DYW oxidoreductase AC731_008715 ENOG4105CHR reductase AC731_008730 ENOG4105C0R drug resistance transporter emrb qaca subfamily AC731_008735 ENOG4105CHR reductase AC731_008740 ENOG4105C1G acyl-Coa dehydrogenase AC731_008745 ENOG4105D2B acyl-CoA dehydrogenase AC731_008750 ENOG4105X7H acyl-CoA dehydrogenase AC731_008765 ENOG4108RK3 acyl-Coa dehydrogenase AC731_008775 ENOG4105C0R drug resistance transporter emrb qaca subfamily AC731_008795 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AC731_008805 ENOG4105DHU Bile acid AC731_008810 ENOG4105CHR reductase AC731_008825 ENOG4107SDU Methyl-accepting chemotaxis AC731_008830 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AC731_008835 ENOG4105CEY Amp-dependent synthetase and ligase AC731_008840 ENOG4105V9V Short-chain dehydrogenase reductase Sdr AC731_008880 ENOG4107RGH Aldehyde dehydrogenase AC731_008900 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) AC731_008905 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) AC731_008955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AC731_008960 ENOG4105BZU Histidine kinase AC731_008990 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AC731_009025 ENOG4105EKQ RNA-directed DNA polymerase AC731_009080 ENOG4105EN6 Membrane AC731_009085 ENOG4105CH2 amidohydrolase AC731_009105 ENOG4105N82 Endonuclease AC731_009120 ENOG4108V3E phosphoribosylglycinamide formyltransferase AC731_009130 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AC731_009135 ENOG4108UM1 dedA family AC731_009140 ENOG4105BZU Histidine kinase AC731_009150 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AC731_009160 ENOG4105BZS acriflavin resistance protein AC731_009165 ENOG410624X efflux transporter, rnd family, mfp subunit AC731_009210 ENOG4105CXB phosphoribosylaminoimidazole synthetase AC731_009215 ENOG4105C02 permease AC731_009220 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AC731_009230 ENOG4105DJ0 Poly(A) Polymerase AC731_009235 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AC731_009250 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AC731_009255 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AC731_009260 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AC731_009265 ENOG4105CD8 aminopeptidase N AC731_009275 ENOG4105CKD glutathione-regulated potassium-efflux system protein AC731_009290 ENOG4105C7K acetolactate synthase AC731_009295 ENOG4108ZP8 Acetolactate synthase small subunit AC731_009300 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AC731_009305 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AC731_009310 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AC731_009320 ENOG4105CS1 NAD(P)H quinone oxidoreductase AC731_009325 ENOG4107S2Z UPF0761 membrane protein AC731_009335 ENOG4105K5M 30s ribosomal protein S16 AC731_009340 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AC731_009345 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AC731_009350 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AC731_009360 ENOG4108M8S permease YjgP YjgQ family protein AC731_009365 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AC731_009380 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AC731_009385 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AC731_009390 ENOG4105ERG peptidase m48, ste24p AC731_009395 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AC731_009525 ENOG4105BZU Histidine kinase AC731_009530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AC731_009545 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AC731_009575 ENOG4105WE2 aldehyde ferredoxin oxidoreductase AC731_009585 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AC731_009595 ENOG4105C26 Dehydrogenase AC731_009635 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AC731_009645 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AC731_009650 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AC731_009655 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AC731_009660 ENOG4106A3M Cytochrome p-450 AC731_009665 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AC731_009670 ENOG4105DZG Dehydrogenase AC731_009705 ENOG4105ETT transcriptional Regulator, LysR family AC731_009715 ENOG4105IPI Membrane AC731_009725 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AC731_009730 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AC731_009735 ENOG4108J2R molybdopterin oxidoreductase AC731_009740 ENOG4108SV3 Tmao reductase system periplasmic protein tort AC731_009745 ENOG4105BZU Histidine kinase AC731_009750 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AC731_009755 ENOG4105C26 Dehydrogenase AC731_009760 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AC731_009765 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AC731_009770 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) AC731_009780 ENOG4108RIR Molybdenum cofactor biosynthesis protein AC731_009785 ENOG4105N42 UPF0307 protein AC731_009790 ENOG4105CMS peptidase U62, modulator of DNA gyrase AC731_009795 ENOG4105CH5 extracellular solute-binding protein, family 7 AC731_009800 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_009810 ENOG4105CVJ phosphoglycerate mutase AC731_009815 ENOG4105CH5 extracellular solute-binding protein, family 7 AC731_009825 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_009830 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AC731_009835 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AC731_009840 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AC731_009845 ENOG4105D06 uba thif-type nad fad binding protein AC731_009855 ENOG4105CN1 protease AC731_009865 ENOG41080HT Transcriptional regulator, arsr family AC731_009870 ENOG4107YZP Rhodanese domain protein AC731_009875 ENOG4105VW4 glutaredoxin 3 AC731_009880 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AC731_009890 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AC731_009895 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AC731_009905 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AC731_009920 ENOG4105D52 delta-aminolevulinic acid dehydratase AC731_009925 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AC731_009935 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) AC731_009940 ENOG4105CRE cytochrome C AC731_009945 ENOG4105ED9 Protein of unknown function (DUF455) AC731_009950 ENOG4105CVM Molybdenum cofactor synthesis domain protein AC731_009955 ENOG4105E66 phosphoriboisomerase A AC731_009960 ENOG4108UTW Plays a role in the regulation of phosphate uptake AC731_009965 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AC731_009970 ENOG4105BZU Histidine kinase AC731_009975 ENOG4108EKC n-acetylglutamate synthase AC731_009980 ENOG4105CSR polyphosphate kinase 2 AC731_009985 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AC731_009990 ENOG4105ECY inositol monophosphatase AC731_009995 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AC731_010000 ENOG4105CV1 Transketolase (EC 2.2.1.1) AC731_010005 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AC731_010010 ENOG4105BZA Phosphoglycerate kinase AC731_010020 ENOG4105CA9 Pyruvate kinase AC731_010045 ENOG4105DUM transcriptional regulator, lysR family AC731_010060 ENOG4106F1P AAA ATPase, central domain protein AC731_010065 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AC731_010070 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AC731_010080 ENOG4105BZA Phosphoglycerate kinase AC731_010085 ENOG4105D2N Aldolase AC731_010105 ENOG4108R3E Dna-3-methyladenine glycosylase i AC731_010110 ENOG4105C8V SAICAR synthetase AC731_010120 ENOG4105DGW oligopeptidase A AC731_010130 ENOG4107RU9 Transcriptional regulator, Crp Fnr family AC731_010140 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AC731_010145 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AC731_010150 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AC731_010155 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AC731_010160 ENOG4105EHM Aminoglycoside phosphotransferase AC731_010165 ENOG4108S0S Nucleotidyl transferase AC731_010170 ENOG4107RAQ aminopeptidase AC731_010175 ENOG4105D0A hydroxylase AC731_010180 ENOG4105D01 (LipO)protein AC731_010185 ENOG4108UMI ABC transporter, permease AC731_010195 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AC731_010200 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AC731_010205 ENOG4105DC1 bifunctional purine biosynthesis protein purh AC731_010210 ENOG4105C12 Phosphoribosylglycinamide synthetase AC731_010215 ENOG4105KWI UPF0339 protein AC731_010220 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AC731_010230 ENOG4105ECF c-methyltransferase AC731_010235 ENOG41076E6 Uroporphyrinogen-III Synthase AC731_010240 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AC731_010250 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AC731_010255 ENOG4108NEV two component transcriptional regulator, LytTR family AC731_010260 ENOG4108HRK Histidine kinase AC731_010265 ENOG4105CH7 arginosuccinase AC731_010270 ENOG4105D9P serine threonine protein kinase AC731_010305 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AC731_010310 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AC731_010315 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AC731_010335 ENOG4108FPN Integrase AC731_010360 ENOG4105DHQ Histidine kinase AC731_010365 ENOG4107QN1 sodium solute AC731_010370 ENOG41062QD Membrane AC731_010375 ENOG4105DHQ Histidine kinase AC731_010380 ENOG4105XJC Two component transcriptional regulator (Winged helix family AC731_010385 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AC731_010390 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AC731_010415 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AC731_010420 ENOG4105CBS Chea signal transduction histidine kinase AC731_010435 ENOG4108V0P LemA family AC731_010445 ENOG4105C5H ABC transporter AC731_010480 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AC731_010485 ENOG4105BZU Histidine kinase AC731_010495 ENOG4108Z7G MaoC domain protein dehydratase AC731_010530 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AC731_010540 ENOG4105CXN decarboxylase AC731_010545 ENOG4105DHP deoxycytidine triphosphate deaminase AC731_010560 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AC731_010565 ENOG4105CHH sulfate transporter AC731_010570 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AC731_010575 ENOG4105D8X mechanosensitive ion channel AC731_010580 ENOG4105C0B DNA polymerase III (alpha subunit) AC731_010585 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AC731_010590 ENOG4105HDD phospholipase AC731_010595 ENOG4105C6K Malic enzyme AC731_010600 ENOG4107QJE Chromosome Partitioning Protein AC731_010605 ENOG4105C4R Atp-dependent dna helicase AC731_010615 ENOG4105C8T Leucyl-tRNA synthetase AC731_010625 ENOG4105DJF DNA polymerase III, delta' subunit AC731_010630 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AC731_010645 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AC731_010650 ENOG4108Z66 YbaK ebsC protein AC731_010665 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AC731_010670 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AC731_010690 ENOG4105VCC 30S ribosomal protein S21 AC731_010700 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC731_010780 ENOG4105CNA YD repeat protein AC731_010810 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AC731_010815 ENOG4105EA8 2-Nitropropane dioxygenase AC731_010840 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AC731_010850 ENOG4107QHF type ii secretion system protein e AC731_010875 ENOG4105C9M aspartyl-trna synthetase AC731_010895 ENOG4105VN1 Heat shock protein AC731_010900 ENOG4105CAS nag kinase AC731_010910 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AC731_010915 ENOG4105DFG type I secretion outer membrane protein AC731_010925 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AC731_010930 ENOG4108UHE carbonic anhydrase AC731_010935 ENOG4105DWF phosphomethylpyrimidine kinase AC731_010940 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AC731_010945 ENOG4105CPQ Dehydrogenase AC731_010950 ENOG4105CDV Ompa motb domain protein AC731_010960 ENOG4105CUY Mechanosensitive ion channel AC731_010965 ENOG4105CX6 glutaminyL-tRNA synthetase AC731_010975 ENOG4106H3A restriction AC731_010985 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AC731_010990 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AC731_010995 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AC731_011005 ENOG4105D65 subunit l AC731_011010 ENOG4105MKQ Monovalent cation H antiporter subunit C AC731_011015 ENOG4108JPZ Monovalent cation H antiporter subunit D AC731_011020 ENOG4105SC1 monovalent cation H antiporter subunit E AC731_011025 ENOG41080TA Multiple resistance and ph regulation protein f AC731_011030 ENOG4105KJM monovalent cation h antiporter subunit g AC731_011035 ENOG4105FE9 pseudouridine synthase AC731_011040 ENOG4105KJM monovalent cation h antiporter subunit g AC731_011045 ENOG4105W4C monovalent cation H antiporter subunit F AC731_011050 ENOG4105SC1 monovalent cation H antiporter subunit E AC731_011055 ENOG4107R4Z monovalent cation h antiporter subunit d AC731_011060 ENOG4108ZE9 Monovalent cation H antiporter subunit C AC731_011065 ENOG4105D65 subunit l AC731_011070 ENOG4108FUF Transcriptional regulator, IclR family AC731_011075 ENOG41061WM D-Alanyl-D-Alanine AC731_011085 ENOG4105C6K Malic enzyme AC731_011090 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) AC731_011095 ENOG4105CHM Aminotransferase AC731_011100 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division AC731_011115 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AC731_011120 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AC731_011130 ENOG4105CEY Amp-dependent synthetase and ligase AC731_011170 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AC731_011180 ENOG4105C6Y Udp-glucose 6-dehydrogenase AC731_011225 ENOG4105K64 Glycosyl transferase, family 2 AC731_011230 ENOG4105K64 Glycosyl transferase, family 2 AC731_011255 ENOG4105CPK Glycosyl transferase (Group 1 AC731_011275 ENOG4105CAQ asparagine synthetase AC731_011280 ENOG4105CPK Glycosyl transferase (Group 1 AC731_011305 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AC731_011320 ENOG4108QV3 biosynthesis protein AC731_011335 ENOG4105CY0 Metallo-Beta-Lactamase AC731_011340 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AC731_011345 ENOG4107TUY Histidine kinase AC731_011355 ENOG4105CHM Aminotransferase AC731_011360 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AC731_011365 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AC731_011370 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AC731_011375 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AC731_011380 ENOG4108MTB glycosyl transferase family AC731_011390 ENOG4105EUB pirin domain protein AC731_011395 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AC731_011405 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AC731_011435 ENOG4105CUZ uba thif-type nad fad binding protein AC731_011450 ENOG4107RDB Major Facilitator AC731_011455 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AC731_011460 ENOG4105CMR udp-glucose 4-epimerase AC731_011465 ENOG4108ZT0 50S ribosomal protein l17 AC731_011470 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AC731_011475 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AC731_011480 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AC731_011485 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AC731_011490 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AC731_011495 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AC731_011500 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AC731_011505 ENOG4105VPB 50S ribosomal protein L30 AC731_011510 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AC731_011515 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AC731_011520 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AC731_011525 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AC731_011530 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AC731_011535 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AC731_011540 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AC731_011545 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AC731_011550 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AC731_011555 ENOG41083MP 50s ribosomal protein l29 AC731_011560 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AC731_011565 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AC731_011570 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AC731_011575 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AC731_011580 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AC731_011585 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AC731_011590 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AC731_011595 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AC731_011600 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AC731_011605 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AC731_011610 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AC731_011615 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AC731_011620 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AC731_011625 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AC731_011630 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AC731_011635 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AC731_011640 ENOG4108VZM 50s ribosomal protein L10 AC731_011645 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AC731_011650 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AC731_011660 ENOG4105PM1 preprotein translocase subunit SecE AC731_011670 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AC731_011705 ENOG4105WH1 Two component transcriptional regulator luxr family AC731_011715 ENOG4105BZU Histidine kinase AC731_011735 ENOG4108IV0 ABC, transporter AC731_011750 ENOG4105C32 Amino acid ABC transporter (Permease) AC731_011755 ENOG4105C0Z ABC transporter AC731_011760 ENOG4108IQE Amp-dependent synthetase and ligase AC731_011770 ENOG4106VK6 Flagellar motor protein AC731_011780 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AC731_011785 ENOG4105D5P Methylmalonyl-coA mutase AC731_011800 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AC731_011810 ENOG4105CGZ zinc metallopeptidase AC731_011815 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AC731_011820 ENOG4105D65 subunit l AC731_011825 ENOG4108ZE9 Monovalent cation H antiporter subunit C AC731_011830 ENOG4107R4Z monovalent cation h antiporter subunit d AC731_011835 ENOG4105SC1 monovalent cation H antiporter subunit E AC731_011840 ENOG4105W4C monovalent cation H antiporter subunit F AC731_011845 ENOG4105KJM monovalent cation h antiporter subunit g AC731_011850 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AC731_011855 ENOG4107QX3 carboxylase AC731_011860 ENOG4105DJT lAO AO transport system ATPase AC731_011865 ENOG4105D5P Methylmalonyl-coA mutase AC731_011870 ENOG4105DRR Transcriptional regulator, GntR family AC731_011875 ENOG4105C37 (CBS) domain AC731_011880 ENOG4107QN1 sodium solute AC731_011885 ENOG41062QD Membrane AC731_011890 ENOG4105E39 Enoyl-CoA hydratase AC731_011905 ENOG4108M8H domain protein AC731_011910 ENOG4108JJA ABC, transporter AC731_011920 ENOG4105WH1 Two component transcriptional regulator luxr family AC731_011955 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AC731_011965 ENOG4105MYN Zinc uptake regulation protein AC731_011975 ENOG4105DIK (ABC) transporter AC731_011980 ENOG4105CC5 ABC transporter AC731_011985 ENOG4105DSE periplasmic solute binding protein AC731_012000 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AC731_012010 ENOG4105C01 Dihydroxy-acid dehydratase AC731_012015 ENOG4108YXG UPF0502 protein AC731_012020 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AC731_012050 ENOG4108UQY Iron-storage protein AC731_012070 ENOG41090R7 Ferric uptake AC731_012075 ENOG4105CA0 peroxidase AC731_012080 ENOG4105DJY efflux transporter, rnd family, mfp subunit AC731_012085 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AC731_012095 ENOG4108ESX Receptor AC731_012110 ENOG4107E2E PKHD-type hydroxylase AC731_012120 ENOG4105E2Y ABC, transporter AC731_012145 ENOG4108S2J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AC731_012165 ENOG41065U4 response regulator AC731_012170 ENOG4105CQZ Histidine kinase AC731_012175 ENOG4105CEY Amp-dependent synthetase and ligase AC731_012200 ENOG4105BZS acriflavin resistance protein AC731_012215 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AC731_012220 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AC731_012225 ENOG4108W2P Methyl-accepting chemotaxis AC731_012245 ENOG4105CQ0 ABC transporter AC731_012255 ENOG4105BZU Histidine kinase AC731_012260 ENOG4105BZ1 (ABC) transporter AC731_012265 ENOG4108JU3 Alkyl hydroperoxide reductase AC731_012275 ENOG4105CRP Part of the ABC transporter FtsEX involved in AC731_012280 ENOG4105CAK Cell division ATP-binding protein ftsE AC731_012300 ENOG4106H78 methyltransferase AC731_012305 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AC731_012310 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AC731_012315 ENOG410890F Dynamin family AC731_012320 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AC731_012330 ENOG41081V9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AC731_012335 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AC731_012345 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AC731_012350 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AC731_012355 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AC731_012365 ENOG4105C3G gtp-binding protein AC731_012370 ENOG4105EKQ RNA-directed DNA polymerase AC731_012385 ENOG4108UYB regulatoR AC731_012390 ENOG4105TX3 Histidine kinase AC731_012400 ENOG4105HEE Binding Domain protein AC731_012410 ENOG4105DH4 Periplasmic copper-binding protein AC731_012415 ENOG4105CIG ABC transporter AC731_012420 ENOG4108T0W nitrous oxide maturation protein NosY AC731_012445 ENOG4105MPD Cytochrome AC731_012450 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AC731_012455 ENOG4105K4P CoA-binding domain protein AC731_012460 ENOG4105DZQ phospholipase D Transphosphatidylase AC731_012465 ENOG4105X23 Endonuclease Exonuclease phosphatase AC731_012470 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AC731_012485 ENOG4105C5F glutamine synthetase AC731_012495 ENOG4105CUX Signal transduction histidine kinase AC731_012500 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AC731_012505 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AC731_012510 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AC731_012515 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AC731_012525 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AC731_012530 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AC731_012535 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AC731_012540 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AC731_012555 ENOG4105CA3 membrane-bound lytic murein transglycosylase AC731_012560 ENOG4105T95 Thiol disulfide interChange protein AC731_012565 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AC731_012595 ENOG4105CDU Replicative dna helicase AC731_012600 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AC731_012605 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AC731_012615 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AC731_012625 ENOG4105CQ7 ATP-dependent helicase AC731_012635 ENOG4105KRS Proteinase inhibitor AC731_012640 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AC731_012645 ENOG4105IPS esterase AC731_012650 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AC731_012655 ENOG4105FR1 rard protein AC731_012670 ENOG4105E2X shikimate dehydrogenase AC731_012675 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AC731_012680 ENOG4105CJW magnesium transporter AC731_012685 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AC731_012690 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AC731_012695 ENOG4105DWF phosphomethylpyrimidine kinase AC731_012700 ENOG4105VCQ rubredoxin AC731_012705 ENOG4108UNF response regulator AC731_012710 ENOG4105M3Z response regulator AC731_012715 ENOG4108V3W Chemotaxis protein, CheW AC731_012720 ENOG4105C8Q Methyl-accepting chemotaxis AC731_012725 ENOG4105CBS Chea signal transduction histidine kinase AC731_012730 ENOG4105C87 Aminotransferase class I and II AC731_012735 ENOG4105CVP deoxyribo-dipyrimidine photolyase AC731_012740 ENOG4108UJU UPF0301 protein AC731_012745 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AC731_012750 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AC731_012755 ENOG4105CXT aspartate transcarbamylase AC731_012760 ENOG4105CD3 dihydroorotase AC731_012765 ENOG4108VIA integral membrane protein AC731_012770 ENOG4105II7 pyrroline-5-carboxylate reductase AC731_012775 ENOG4105DFA alanine racemase domain protein AC731_012780 ENOG4105CZX twitching motility protein AC731_012785 ENOG4105CZX twitching motility protein AC731_012790 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AC731_012805 ENOG4105QAX Iron-sulfur AC731_012810 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AC731_012845 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AC731_012860 ENOG4105K4U addiction module toxin, RelE StbE family AC731_012915 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AC731_012920 ENOG4105BZU Histidine kinase AC731_012930 ENOG4108YXA Membrane AC731_012945 ENOG4105D58 Diguanylate phosphodiesterase AC731_012950 ENOG4105BZU Histidine kinase AC731_012955 ENOG4105BZU Histidine kinase AC731_012960 ENOG4105W2Z cytochrome C, class I AC731_012965 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AC731_012970 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AC731_012975 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AC731_012980 ENOG4105EFT decarboxylase AC731_012985 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AC731_013000 ENOG4105C1J atp-dependent rna helicase AC731_013005 ENOG4105CYC Transferase AC731_013020 ENOG4105DJ4 phosphatidylserine decarboxylase AC731_013025 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AC731_013030 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AC731_013035 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AC731_013040 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AC731_013045 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AC731_013055 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AC731_013060 ENOG4105EHG Permease protein AC731_013065 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AC731_013070 ENOG4108YZT Adenosylcobinamide kinase AC731_013075 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AC731_013080 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AC731_013085 ENOG4105CVJ phosphoglycerate mutase AC731_013090 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AC731_013095 ENOG4105C6Y Udp-glucose 6-dehydrogenase AC731_013105 ENOG4107XU6 Glycosyl transferase (Group 1 AC731_013110 ENOG4105CG5 Glycosyl transferase (Group 1 AC731_013115 ENOG4105CPK Glycosyl transferase (Group 1 AC731_013120 ENOG4108I69 Glycosyl transferases group 1 AC731_013130 ENOG4105D16 lipopolysaccharide heptosyltransferase i AC731_013140 ENOG4107TYR Glycosyl Transferase AC731_013145 ENOG4107BJW polysaccharide deacetylase AC731_013150 ENOG4105BZ1 (ABC) transporter AC731_013165 ENOG4105EY8 ABC transporter AC731_013185 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AC731_013195 ENOG4105D3Q Sugar transferase AC731_013220 ENOG4107MBT Plasmid stabilisation system protein AC731_013230 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AC731_013235 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AC731_013240 ENOG4105C2M dna polymerase I AC731_013245 ENOG4108URH decarboxylase AC731_013260 ENOG4105CUV Homoserine Kinase AC731_013275 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AC731_013280 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AC731_013285 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AC731_013290 ENOG4108Z03 MAF-like protein AC731_013295 ENOG4105C03 ribonuclease AC731_013315 ENOG4105C4M (Ubiquinol oxidase) subunit I AC731_013320 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AC731_013335 ENOG4108IV0 ABC, transporter AC731_013340 ENOG4105C0Z ABC transporter AC731_013345 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AC731_013350 ENOG4105C32 Amino acid ABC transporter (Permease) AC731_013360 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AC731_013365 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AC731_013380 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AC731_013390 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AC731_013395 ENOG4105D1S lipid A biosynthesis AC731_013405 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AC731_013415 ENOG4107SDU Methyl-accepting chemotaxis AC731_013420 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AC731_013425 ENOG4105DX0 Hemolysin A AC731_013430 ENOG4105SYT Methylenetetrahydrofolate reductase AC731_013435 ENOG4105BZU Histidine kinase AC731_013440 ENOG4105D7A ATP-binding protein AC731_013450 ENOG4105CDY transcriptional regulatory protein AC731_013460 ENOG4105K8R UPF0145 protein AC731_013465 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AC731_013540 ENOG4108XEP Alpha Beta Hydrolase Fold protein AC731_013545 ENOG4108U78 Glutathione S-transferase AC731_013550 ENOG4105VF7 tolerance protein AC731_013555 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AC731_013565 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AC731_013570 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AC731_013575 ENOG4107YIM Involved in the transcription termination process (By similarity) AC731_013590 ENOG41081J6 Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) AC731_013625 ENOG4105E89 ABC transporter AC731_013630 ENOG4105E5Q amino acid AbC transporter AC731_013635 ENOG4105CDA abc transporter atp-binding protein AC731_013645 ENOG4108W2Y isochorismatase AC731_013650 ENOG4105C1J atp-dependent rna helicase AC731_013655 ENOG4105K70 DNA-binding protein AC731_013670 ENOG4105CEN a g-specific adenine glycosylase AC731_013680 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AC731_013695 ENOG4105C32 Amino acid ABC transporter (Permease) AC731_013710 ENOG4105C5X domain protein AC731_013715 ENOG4105D82 Glutamate dehydrogenase AC731_013725 ENOG4109066 lysm domain bon superfamily protein AC731_013750 ENOG410811B TRANSCRIPTIONal AC731_013755 ENOG4105CFP Peptidase U32 AC731_013760 ENOG4107ZXU DSBA oxidoreductase AC731_013770 ENOG4105BZU Histidine kinase AC731_013780 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) AC731_013785 ENOG4105BZU Histidine kinase AC731_013825 ENOG4107R7Y intracellular protease Pfpi family AC731_013830 ENOG4105EKQ RNA-directed DNA polymerase AC731_013845 ENOG4105C4R Atp-dependent dna helicase AC731_013865 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AC731_013870 ENOG4105BZU Histidine kinase AC731_013890 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AC731_013895 ENOG4105CHR reductase AC731_013935 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AC731_013940 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AC731_013945 ENOG4108Z43 UPF0250 protein AC731_013950 ENOG4105F0I Aminotransferase AC731_013955 ENOG4105DZ1 carboxypeptidase AC731_013965 ENOG4105CNI cell division protein FtsW AC731_013970 ENOG4105CJN penicillin-binding protein AC731_013985 ENOG4105DFF Rod shape-determining protein mreb AC731_013990 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AC731_013995 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AC731_014005 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AC731_014010 ENOG4105CUC YeeE YedE family protein AC731_014015 ENOG4105E7A Glutamine amidotransferase AC731_014030 ENOG4105BZU Histidine kinase AC731_014035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC731_014045 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AC731_014060 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AC731_014065 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AC731_014070 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AC731_014075 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AC731_014080 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AC731_014085 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AC731_014090 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AC731_014095 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) AC731_014115 ENOG4105FA0 parb-like partition protein AC731_014120 ENOG4107QJE Chromosome Partitioning Protein AC731_014125 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AC731_014130 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AC731_014135 ENOG4105E39 Enoyl-CoA hydratase AC731_014140 ENOG4105CD5 CoA-binding domain protein AC731_014145 ENOG4105E39 Enoyl-CoA hydratase AC731_014155 ENOG4105F4R Transcriptional regulator mode AC731_014165 ENOG4105J0Q Transcriptional regulator AC731_014180 ENOG4105BZU Histidine kinase AC731_014190 ENOG4105BZU Histidine kinase AC731_014195 ENOG4105BZ1 (ABC) transporter AC731_014210 ENOG4105FYV Amp nucleosidase AC731_014230 ENOG4105EKQ RNA-directed DNA polymerase AC731_014235 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AC731_014255 ENOG4105NVB glycoside hydrolase, family 19 AC731_014265 ENOG4105CIA precorrin-4 C(11)-methyltransferase AC731_014270 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AC731_014275 ENOG41081F0 Precorrin-8x methylmutase AC731_014280 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) AC731_014285 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase AC731_014290 ENOG4105DVK Precorrin-2 c20-methyltransferase AC731_014295 ENOG4108P62 biosynthesis protein (CbiG) AC731_014315 ENOG4105RK9 auxin efflux carrier AC731_014320 ENOG4105JXH GntR family transcriptional regulator AC731_014330 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AC731_014340 ENOG4105E9Z Nad-dependent epimerase dehydratase AC731_014345 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AC731_014355 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_014360 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AC731_014365 ENOG4105CTX dehydratase AC731_014375 ENOG4105BZW Glycerate kinase AC731_014380 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AC731_014395 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AC731_014400 ENOG4105C8Q Methyl-accepting chemotaxis AC731_014420 ENOG4105DH7 May be involved in recombination (By similarity) AC731_014430 ENOG4105I08 Pseudouridine synthase AC731_014445 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AC731_014455 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AC731_014465 ENOG4108K3Z AraC family transcriptional regulator AC731_014480 ENOG410630Q Methylamine utilization AC731_014485 ENOG4108YF6 methylamine dehydrogenase accessory protein MauD AC731_014490 ENOG4108XDC Dehydrogenase AC731_014495 ENOG4105CA0 peroxidase AC731_014510 ENOG4105GXZ Ferredoxin-type protein NapH AC731_014520 ENOG4105KA7 cytochrome C AC731_014525 ENOG4108NVR Methyl-accepting chemotaxis AC731_014530 ENOG4105C0H protease AC731_014535 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AC731_014545 ENOG4105C9U ATP-dependent DNA helicase RecQ AC731_014550 ENOG4108RPN Protein smg homolog AC731_014555 ENOG4105C79 DNA protecting protein DprA AC731_014560 ENOG4108WZM domain protein AC731_014565 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AC731_014570 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AC731_014575 ENOG4105D0M Protease HtpX homolog AC731_014580 ENOG4105EGS Mechanosensitive ion channel AC731_014595 ENOG4105CBP Major Facilitator AC731_014600 ENOG4105E9K Isocitrate dehydrogenase AC731_014620 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AC731_014625 ENOG4108VKG metal-dependent hydrolase AC731_014630 ENOG4105T86 cytochrome C AC731_014635 ENOG4105BZU Histidine kinase AC731_014645 ENOG4107SKI cobyrinic Acid a,c-diamide synthase AC731_014660 ENOG4105FFC UPF0187 protein AC731_014670 ENOG4105J5J Outer membrane porin AC731_014685 ENOG4105BZU Histidine kinase AC731_014690 ENOG4105DRR Transcriptional regulator, GntR family AC731_014695 ENOG4105HF0 Membrane AC731_014700 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AC731_014715 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AC731_014725 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AC731_014730 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AC731_014735 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AC731_014740 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AC731_014745 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AC731_014750 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AC731_014755 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AC731_014765 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AC731_014780 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AC731_014785 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AC731_014800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AC731_014805 ENOG4105C1A potassium transporter peripheral membrane AC731_014810 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AC731_014815 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AC731_014820 ENOG4105C25 Primosomal protein n' AC731_014825 ENOG4105CPI Metal Dependent Phosphohydrolase AC731_014830 ENOG4105DKQ ROK family AC731_014835 ENOG41077A9 carbonic anhydrase AC731_014855 ENOG4105EYM Major Facilitator superfamily AC731_014865 ENOG4105DWV Homoserine O-trans-acetylase AC731_014870 ENOG4105DWV Homoserine O-trans-acetylase AC731_014875 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AC731_014880 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AC731_014885 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AC731_014890 ENOG4105D07 Signal peptide peptidase, SppA AC731_014895 ENOG4108V1U phospholipid-binding protein AC731_014900 ENOG4105CSA Coproporphyrinogen iii oxidase AC731_014905 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AC731_014910 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AC731_014920 ENOG4107WDG serine threonine protein kinase AC731_014925 ENOG4105DSJ YicC domain protein AC731_014930 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AC731_014935 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AC731_014940 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AC731_014945 ENOG4105BZU Histidine kinase AC731_014955 ENOG4105DVT helicase AC731_014965 ENOG4105BZU Histidine kinase AC731_014970 ENOG4105WH1 Two component transcriptional regulator luxr family AC731_014975 ENOG4108ZNS ferredoxin-type protein NapF AC731_014985 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AC731_014990 ENOG4108BGM Quinol dehydrogenase periplasmic component AC731_014995 ENOG4105GXZ Ferredoxin-type protein NapH AC731_015005 ENOG4105CUW cytochrome C-TYPE protein AC731_015010 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AC731_015015 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AC731_015020 ENOG41060IM Heme exporter protein AC731_015030 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AC731_015035 ENOG4105DA4 cytochrome c-type biogenesis protein AC731_015040 ENOG4107QX9 Thiol disulfide interChange protein AC731_015045 ENOG4108M1T Cytochrome c-type biogenesis protein AC731_015050 ENOG4106FI7 cytochrome c-type biogenesis protein AC731_015055 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AC731_015060 ENOG4105MWK D-amino acid dehydrogenase, small subunit AC731_015065 ENOG4105EW9 transcriptional regulator AsnC family AC731_015070 ENOG4105EKQ RNA-directed DNA polymerase AC731_015080 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AC731_015085 ENOG41080Z8 PHOSPHOCARRIER protein AC731_015090 ENOG4105YHU PTS system AC731_015095 ENOG4105C94 Transporter AC731_015190 ENOG4105KK6 nuclease AC731_015200 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS AC731_015205 ENOG4108RAV Conserved protein AC731_015275 ENOG4107ZQN disulfide bond AC731_015330 ENOG4105GR3 Histidine kinase AC731_015350 ENOG4105C5H ABC transporter AC731_015355 ENOG4105BZU Histidine kinase AC731_015365 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AC731_015370 ENOG4105BZU Histidine kinase AC731_015385 ENOG4105EYH Exonuclease AC731_015390 ENOG4105C4W S-formylglutathione hydrolase AC731_015395 ENOG4107QPD alcohol dehydrogenase AC731_015400 ENOG4105EJC lysr family transcriptional regulator AC731_015420 ENOG4105E5G Alpha beta hydrolase fold AC731_015425 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AC731_015435 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_015445 ENOG4105C1P efflux transporter, rnd family, mfp subunit AC731_015450 ENOG4105BZS acriflavin resistance protein AC731_015455 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AC731_015460 ENOG4105CKI cobalamin synthesis protein AC731_015470 ENOG410828M hemerythrin-like, metal-binding protein AC731_015480 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AC731_015505 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AC731_015510 ENOG4107RNH Outer membrane receptor FepA AC731_015520 ENOG4105BZU Histidine kinase AC731_015525 ENOG4105DSY exodeoxyribonuclease V, gamma AC731_015530 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AC731_015540 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein AC731_015545 ENOG4105BZU Histidine kinase AC731_015555 ENOG4107QKA exodeoxyribonuclease V beta AC731_015560 ENOG4107QYX exodeoxyribonuclease v alpha AC731_015565 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AC731_015570 ENOG4108URH decarboxylase AC731_015580 ENOG4105BZU Histidine kinase AC731_015600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AC731_015605 ENOG4105CY2 Citrate transporter AC731_015620 ENOG4105C6T cysteine synthase AC731_015625 ENOG4107RCI amp-dependent synthetase and ligase AC731_015630 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the AC731_015635 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AC731_015640 ENOG4105BZU Histidine kinase AC731_015645 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AC731_015650 ENOG4105BZU Histidine kinase AC731_015675 ENOG4108UJV acyl-CoA thioesterase i AC731_015685 ENOG4108IV0 ABC, transporter AC731_015690 ENOG4105C0Z ABC transporter AC731_015695 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AC731_015700 ENOG4105C32 Amino acid ABC transporter (Permease) AC731_015705 ENOG4105CP9 extracellular ligand-binding receptor AC731_015715 ENOG4105EW9 transcriptional regulator AsnC family AC731_015725 ENOG4105D7Z glutathione synthase AC731_015730 ENOG41081YB ApbE family AC731_015740 ENOG4105N14 lysine exporter protein LysE YggA AC731_015745 ENOG4105DKK Benzoate AC731_015750 ENOG4107RT3 EamA-like transporter family AC731_015760 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AC731_015765 ENOG4108IEG Formate dehydrogenase Alpha subunit AC731_015780 ENOG4105C5Q Transcriptional regulator AC731_015790 ENOG4105E3J oxidoreductase AC731_015810 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AC731_015825 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_015855 ENOG4105C5H ABC transporter AC731_015860 ENOG4105CPI Metal Dependent Phosphohydrolase AC731_015865 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein AC731_015870 ENOG4105CIY formyltetrahydrofolate deformylase AC731_015875 ENOG4105CZK Aspartate kinase AC731_015880 ENOG4105BZU Histidine kinase AC731_015885 ENOG4108YZA Nitrogen regulatory protein pii AC731_015895 ENOG4105W0Z cytoplasmic protein AC731_015900 ENOG4105C0P Mg chelatase subunit ChlI AC731_015910 ENOG4108IV0 ABC, transporter AC731_015915 ENOG4105C0Z ABC transporter AC731_015920 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AC731_015925 ENOG4105C32 Amino acid ABC transporter (Permease) AC731_015935 ENOG4105CP9 extracellular ligand-binding receptor AC731_015950 ENOG4105C3R Methionine synthase AC731_015955 ENOG41080RH Thioredoxin AC731_015960 ENOG41063Z6 transcriptional regulator, lysR family AC731_015975 ENOG4107SDU Methyl-accepting chemotaxis AC731_015980 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AC731_016000 ENOG4105EHZ conserved protein UCP016719 AC731_016015 ENOG4105D64 Mechanosensitive ion channel AC731_016025 ENOG4105C31 Tryptophanyl-tRNA synthetase AC731_016040 ENOG4107R11 Transcriptional regulator AC731_016045 ENOG4108IJ6 ABC transporter AC731_016055 ENOG4108I5D sulfate abc transporter AC731_016065 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AC731_016070 ENOG4105HEI LysR family (Transcriptional regulator AC731_016075 ENOG4105DS1 cytochrome b561 AC731_016085 ENOG4108YYC ycei family AC731_016100 ENOG4105C5I Dehydrogenase AC731_016105 ENOG4105MWK D-amino acid dehydrogenase, small subunit AC731_016110 ENOG4108FUF Transcriptional regulator, IclR family AC731_016120 ENOG4108E94 phosphate acetyltransferase AC731_016125 ENOG4105C8Q Methyl-accepting chemotaxis AC731_016130 ENOG4105P69 integral membrane protein AC731_016140 ENOG4108FUF Transcriptional regulator, IclR family AC731_016190 ENOG4105HMI Membrane AC731_016195 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AC731_016200 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AC731_016205 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AC731_016210 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AC731_016220 ENOG4105CJP fad dependent oxidoreductase AC731_016225 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AC731_016230 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter AC731_016235 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_016250 ENOG4105DUM transcriptional regulator, lysR family AC731_016265 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AC731_016275 ENOG4105D4A Cell wall formation (By similarity) AC731_016280 ENOG4105CQB FAD linked oxidase domain protein AC731_016300 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) AC731_016325 ENOG4108IV0 ABC, transporter AC731_016340 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AC731_016345 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein AC731_016350 ENOG4105BZU Histidine kinase AC731_016355 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AC731_016360 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AC731_016365 ENOG4107QWE )-transporter AC731_016375 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AC731_016380 ENOG4108YZ9 Urea amidohydrolase subunit gamma AC731_016385 ENOG4105KI2 Urea amidohydrolase subunit beta AC731_016390 ENOG4105CQM Urea amidohydrolase subunit alpha AC731_016395 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) AC731_016400 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AC731_016405 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AC731_016415 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AC731_016415 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AC731_016420 ENOG4105BZU Histidine kinase AC731_016425 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AC731_016480 ENOG4108UGV hypoxanthine phosphoribosyltransferase AC731_016485 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AC731_016490 ENOG4105C2W permease AC731_016505 ENOG4105TNS Conserved Protein AC731_016510 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AC731_016515 ENOG4105CGK Exodeoxyribonuclease III AC731_016520 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AC731_016530 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AC731_016540 ENOG4105M4H endoribonuclease L-psp AC731_016545 ENOG4105W39 Membrane AC731_016560 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AC731_016565 ENOG4105CHR reductase AC731_016585 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AC731_016600 ENOG4107SC1 transglycosylase AC731_016605 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AC731_016610 ENOG4105C7B Threonine dehydratase AC731_016615 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) AC731_016620 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AC731_016625 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AC731_016630 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC731_016635 ENOG4108IUZ ABC transporter AC731_016640 ENOG4108004 Modulates RecA activity (By similarity) AC731_016645 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AC731_016650 ENOG4107TH8 cina domain protein AC731_016655 ENOG4108ZAI phosphatidylglycerophosphatase a AC731_016660 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AC731_016665 ENOG4105XPQ lipid carrier protein AC731_016670 ENOG4106RZ4 Peptidase U32 AC731_016675 ENOG4105CFP Peptidase U32 AC731_016680 ENOG4105CK7 Sodium proline symporter AC731_016685 ENOG4105C8Y Acetylornithine aminotransferase AC731_016690 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AC731_016695 ENOG4105C75 arginyL-tRNA synthetase AC731_016725 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AC731_016740 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AC731_016750 ENOG4108Z6Z Transcriptional regulator AC731_016760 ENOG41077A9 carbonic anhydrase AC731_016765 ENOG4105CHU acetyl-coa acetyltransferase AC731_016770 ENOG4105C1G acyl-Coa dehydrogenase AC731_016775 ENOG4105DJ2 Major Facilitator Superfamily AC731_016790 ENOG4105KHM amidohydrolase 2 AC731_016800 ENOG4105GAK amidohydrolase 2 AC731_016820 ENOG4105CPC Aldo Keto reductase AC731_016840 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AC731_016845 ENOG4108R85 Short chain dehydrogenase AC731_016850 ENOG41063TF transcriptional regulator (AraC AC731_016870 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AC731_016875 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AC731_016880 ENOG4105G2Y Transcriptional regulator AC731_016905 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_016910 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AC731_016920 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AC731_016930 ENOG4107S9B Shikimate dehydrogenase AC731_016935 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_016940 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter AC731_016945 ENOG4107HP6 Transcriptional regulator AC731_016965 ENOG4105J4Q Transcriptional regulator AC731_016990 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AC731_017000 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AC731_017005 ENOG4105E2X shikimate dehydrogenase AC731_017015 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase AC731_017035 ENOG4105D82 Glutamate dehydrogenase AC731_017040 ENOG4107YNJ LysR family Transcriptional regulator AC731_017045 ENOG4105EJQ L-serine dehydratase AC731_017050 ENOG4107SCJ type I restriction enzyme EcoKI subunit R AC731_017060 ENOG4105CVR type I restriction-modification system AC731_017095 ENOG4105C1G acyl-Coa dehydrogenase AC731_017115 ENOG4107QX3 carboxylase AC731_017120 ENOG4105CGU Enoyl-CoA hydratase AC731_017130 ENOG4105CEY Amp-dependent synthetase and ligase AC731_017135 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AC731_017145 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AC731_017150 ENOG4105BZ1 (ABC) transporter AC731_017160 ENOG4105P52 geranylgeranyl reductase AC731_017180 ENOG4105J9X quinohemoprotein amine dehydrogenase gamma subunit AC731_017195 ENOG4105C26 Dehydrogenase AC731_017205 ENOG4105BZG amino acid carrier protein AC731_017210 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AC731_017225 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AC731_017230 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AC731_017235 ENOG4108UPT UPF0178 protein AC731_017250 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AC731_017255 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AC731_017265 ENOG4105KCK Peptidoglycan-associated lipoprotein AC731_017270 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AC731_017280 ENOG4105M8F Biopolymer transport protein exbD tolR AC731_017285 ENOG4105E02 MotA TolQ exbB proton channel AC731_017290 ENOG4107YD3 Thioesterase AC731_017300 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AC731_017305 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AC731_017320 ENOG4107QX8 SPFH domain, Band 7 family protein AC731_017330 ENOG4105VEJ Heat shock protein AC731_017345 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AC731_017350 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AC731_017370 ENOG4107R11 Transcriptional regulator AC731_017375 ENOG4107RB3 L-asparaginase AC731_017380 ENOG4105CKD glutathione-regulated potassium-efflux system protein AC731_017385 ENOG4108JJ7 ABC transporter AC731_017395 ENOG4107QPN acyl-Coa dehydrogenase AC731_017400 ENOG4105CHU acetyl-coa acetyltransferase AC731_017405 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AC731_017410 ENOG4105NAU thioesterase Superfamily protein AC731_017415 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AC731_017425 ENOG4105CHU acetyl-coa acetyltransferase AC731_017435 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AC731_017440 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AC731_017455 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) AC731_017480 ENOG41085EG Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) AC731_017485 ENOG4105KME endoribonuclease L-psp AC731_017490 ENOG4105CB5 ATP-dependent DNA helicase recG AC731_017495 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AC731_017500 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AC731_017505 ENOG4105SKN orotidine 5''-phosphate decarboxylase AC731_017510 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AC731_017530 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AC731_017535 ENOG4105XQ6 frataxin-like protein AC731_017540 ENOG4108JQC penicillin-binding protein 1A AC731_017565 ENOG4105E4G Type IV pilus AC731_017570 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AC731_017575 ENOG4105D49 3-dehydroquinate synthase AC731_017580 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AC731_017595 ENOG4105DEF Extracellular solute-binding protein, family 5 AC731_017615 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AC731_017625 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AC731_017630 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AC731_017640 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AC731_017650 ENOG4105C58 cytochrome c oxidase accessory protein ccog AC731_017665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AC731_017670 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AC731_017680 ENOG4105GR3 Histidine kinase AC731_017705 ENOG4107R16 Multicopper oxidase AC731_017730 ENOG4108IJF Heavy metal efflux pump, CzcA AC731_017760 ENOG4105C8Q Methyl-accepting chemotaxis AC731_017765 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AC731_017775 ENOG4105BZU Histidine kinase AC731_017790 ENOG4105N0V mono-oxygenase ydhR AC731_017800 ENOG4108ZX5 transcriptional regulator AC731_017805 ENOG4105C0Z ABC transporter AC731_017815 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AC731_017820 ENOG4105CP9 extracellular ligand-binding receptor AC731_017825 ENOG4108IV0 ABC, transporter AC731_017830 ENOG4108IQE Amp-dependent synthetase and ligase AC731_017835 ENOG4105CGU Enoyl-CoA hydratase AC731_017840 ENOG4105C1G acyl-Coa dehydrogenase AC731_017845 ENOG4105CHU acetyl-coa acetyltransferase AC731_017855 ENOG4105CEY Amp-dependent synthetase and ligase AC731_017860 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AC731_017880 ENOG4105IPI Membrane AC731_017890 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AC731_017895 ENOG4105C9A Phoh family AC731_017900 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AC731_017905 ENOG4108JU5 Magnesium and cobalt efflux protein AC731_017910 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AC731_017915 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit AC731_017920 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AC731_017925 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AC731_017930 ENOG4105E9Q Acyl-transferase AC731_017935 ENOG4105KZX Pterin carbinolamine dehydratase AC731_017945 ENOG4105E39 Enoyl-CoA hydratase AC731_017950 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AC731_017960 ENOG4105C2X Arabinose 5-phosphate isomerase AC731_018000 ENOG4107QHF type ii secretion system protein e AC731_018005 ENOG4105GVR general secretion pathway protein D AC731_018010 ENOG4105DHJ ABC, transporter AC731_018015 ENOG4105CY3 ABC transporter, permease AC731_018020 ENOG4107PE3 Mammalian cell entry related domain protein AC731_018040 ENOG4105DA5 (ABC) transporter AC731_018045 ENOG4105E3A (ABC) transporter AC731_018055 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AC731_018060 ENOG4105NXH GreA GreB family elongation factor AC731_018065 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AC731_018070 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AC731_018075 ENOG4105CIH Imidazole acetol-phosphate transaminase AC731_018080 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AC731_018085 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AC731_018090 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AC731_018095 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AC731_018100 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AC731_018105 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase AC731_018110 ENOG4105K59 histidine triad (HIT) protein AC731_018115 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AC731_018120 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AC731_018130 ENOG4105C0H protease AC731_018135 ENOG4107QNR UPF0135 protein AC731_018150 ENOG4105CMV Succinyl-CoA synthetase subunit beta AC731_018155 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AC731_018165 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AC731_018170 ENOG4107QHF type ii secretion system protein e AC731_018175 ENOG4105DJV ribulose-phosphate 3-epimerase AC731_018180 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AC731_018190 ENOG4105DDQ anthranilate synthase AC731_018195 ENOG4107QYG anthranilate phosphoribosyltransferase AC731_018200 ENOG4105DK0 Indole-3-glycerol phosphate synthase AC731_018210 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AC731_018215 ENOG4108V1T peptidylprolyl cis-trans isomerase AC731_018220 ENOG4108XM1 transcriptional regulator AsnC family AC731_018225 ENOG4105C8J )-transporter AC731_018245 ENOG4105BZU Histidine kinase AC731_018250 ENOG4105BZU Histidine kinase AC731_018260 ENOG4105C9U ATP-dependent DNA helicase RecQ AC731_018290 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AC731_018310 ENOG4108IXY short-chain dehydrogenase reductase AC731_018320 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AC731_018325 ENOG4105BZ9 Cytochrome C oxidase, subunit I AC731_018330 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) AC731_018340 ENOG4107QS1 Cytochrome C Oxidase, Subunit III AC731_018365 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AC731_018375 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC731_018380 ENOG4108Z9W Outer membrane porin AC731_018385 ENOG4108Z9W Outer membrane porin AC731_018390 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AC731_018405 ENOG4105K59 histidine triad (HIT) protein AC731_018425 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AC731_018430 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AC731_018435 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AC731_018440 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AC731_018450 ENOG4105DFU Cell wall formation (By similarity) AC731_018455 ENOG4105W4M Transport-associated protein AC731_018460 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AC731_018465 ENOG41082RQ UPF0102 protein AC731_018470 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AC731_018475 ENOG4105EKE dihydroorotase AC731_018490 ENOG4108V6E Cell division protein mraZ AC731_018495 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AC731_018500 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AC731_018505 ENOG4105CJN penicillin-binding protein AC731_018510 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AC731_018515 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AC731_018520 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AC731_018525 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AC731_018530 ENOG4105CNI cell division protein FtsW AC731_018535 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AC731_018540 ENOG4105DFU Cell wall formation (By similarity) AC731_018545 ENOG4105CPF Cell wall formation (By similarity) AC731_018550 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AC731_018555 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AC731_018560 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AC731_018565 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AC731_018580 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AC731_018585 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AC731_018620 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AC731_018625 ENOG4105NWN ApaG protein AC731_018630 ENOG4107QTF adenylosuccinate lyase AC731_018640 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AC731_018645 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AC731_018650 ENOG4105VIE preprotein translocase, subunit YajC AC731_018655 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AC731_018660 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AC731_018715 ENOG4105CH5 extracellular solute-binding protein, family 7 AC731_018725 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_018735 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AC731_018755 ENOG41063Z6 transcriptional regulator, lysR family AC731_018765 ENOG4108MN8 Membrane AC731_018770 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AC731_018775 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AC731_018780 ENOG4108ZXC Two component transcriptional regulator, luxr family AC731_018785 ENOG4105BZU Histidine kinase AC731_018790 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AC731_018795 ENOG4108RA0 tripartite ATP-independent periplasmic transporter, DctQ component AC731_018800 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AC731_018805 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AC731_018810 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AC731_018825 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AC731_018830 ENOG4105CUT histidyl-tRNA synthetase AC731_018840 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AC731_018845 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AC731_018850 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AC731_018855 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AC731_018860 ENOG4107QJR hflk protein AC731_018865 ENOG4105EPW hflc protein AC731_018875 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AC731_018880 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AC731_018895 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AC731_018900 ENOG4105C2N RNA methyltransferase TrmH family group 3 AC731_018905 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase AC731_018915 ENOG4107QWE )-transporter AC731_018930 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AC731_018945 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AC731_018950 ENOG4107QMP dna polymerase iii subunits gamma and tau AC731_018955 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AC731_018960 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AC731_018965 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AC731_018970 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AC731_018975 ENOG4105EIX cytochrome c1 AC731_018980 ENOG4107MKT Stringent starvation protein a AC731_018985 ENOG4105KB2 stringent starvation protein b AC731_018990 ENOG4105Y3Q hemerythrin-like, metal-binding protein AC731_018995 ENOG4105MWK D-amino acid dehydrogenase, small subunit AC731_019000 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AC731_019010 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AC731_019030 ENOG4105CPP Dehydrogenase, E1 component AC731_019050 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AC731_019085 ENOG4105EYF MMPL domain protein AC731_019090 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AC731_019095 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AC731_019100 ENOG4105K46 50S ribosomal protein l27 AC731_019105 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AC731_019115 ENOG4108ZF3 Phosphatase AC731_019125 ENOG4105W8H transhydrogenase (subunit alpha AC731_019130 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AC731_019140 ENOG4105BZU Histidine kinase AC731_019145 ENOG4105C1J atp-dependent rna helicase AC731_019150 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) AC731_019160 ENOG4105BZ7 extracellular solute-binding protein family 1 AC731_019165 ENOG4105EAH synthase AC731_019175 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AC731_019180 ENOG4108WBT adenosyltransferase AC731_019185 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AC731_019200 ENOG4105DNZ Alpha Beta Hydrolase AC731_019215 ENOG4105CM2 brancheD-chain amino acid aminotransferase AC731_019230 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AC731_019255 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AC731_019260 ENOG4105QD6 exported protein AC731_019270 ENOG4105D1U peptidase U62 modulator of DNA gyrase AC731_019285 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AC731_019295 ENOG4107WP9 Histidine kinase AC731_019305 ENOG4105E4C Lytic transglycosylase catalytic AC731_019310 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AC731_019315 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AC731_019325 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) AC731_019330 ENOG4108UKZ OsmC family AC731_019335 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AC731_019340 ENOG4108UJD 30S ribosomal protein S9 AC731_019345 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AC731_019350 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AC731_019355 ENOG4105DR5 peptidase AC731_019360 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AC731_019365 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)