locus-tag	class	description
AC731_000020	COG2205	protein histidine kinase activity
AC731_000025	COG0745	RESPONSE REGULATOR receiver
AC731_000040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC731_000045	COG0542	response to heat
AC731_000050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AC731_000055	COG1278	Cold shock
AC731_000060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AC731_000065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AC731_000070	COG2003	Belongs to the UPF0758 family
AC731_000080	COG0756	dUTP diphosphatase activity
AC731_000095	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC731_000105	COG0640	Transcriptional regulator
AC731_000115	COG4654	Cytochrome c, class I
AC731_000150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC731_000165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC731_000190	COG0697	spore germination
AC731_000230	COG3278	Belongs to the heme-copper respiratory oxidase family
AC731_000245	COG2010	Cytochrome c
AC731_000270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC731_000275	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC731_000290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC731_000295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC731_000310	COG2217	Heavy metal translocating P-type atpase
AC731_000320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AC731_000325	COG2201	protein-glutamate methylesterase activity
AC731_000335	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AC731_000340	COG0840	transmembrane signaling receptor activity
AC731_000345	COG0835	chemotaxis
AC731_000350	COG0840	transmembrane signaling receptor activity
AC731_000355	COG2198	Histidine kinase
AC731_000355	COG0643	Histidine kinase
AC731_000375	COG0402	S-adenosylhomocysteine deaminase activity
AC731_000400	COG2204	response regulator
AC731_000430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC731_000460	COG1230	cation diffusion facilitator family transporter
AC731_000515	COG0840	transmembrane signaling receptor activity
AC731_000520	COG0840	transmembrane signaling receptor activity
AC731_000525	COG0326	Molecular chaperone. Has ATPase activity
AC731_000570	COG0564	pseudouridine synthase activity
AC731_000585	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC731_000590	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_000605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC731_000610	COG1752	Esterase of the alpha-beta hydrolase superfamily
AC731_000615	COG0277	FAD linked oxidase domain protein
AC731_000650	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC731_000655	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AC731_000665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AC731_000675	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_000680	COG0028	Belongs to the TPP enzyme family
AC731_000685	COG0440	acetolactate synthase activity
AC731_000690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AC731_000695	COG2814	Major facilitator Superfamily
AC731_000700	COG0501	Belongs to the peptidase M48B family
AC731_000705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC731_000715	COG0066	3-isopropylmalate dehydratase activity
AC731_000720	COG0473	3-isopropylmalate dehydrogenase activity
AC731_000740	COG0101	tRNA pseudouridine synthase activity
AC731_000745	COG0135	phosphoribosylanthranilate isomerase activity
AC731_000750	COG0133	tryptophan synthase activity
AC731_000755	COG0159	tryptophan synthase activity
AC731_000760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AC731_000765	COG0285	dihydrofolate synthase activity
AC731_000790	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC731_000795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC731_000800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC731_000805	COG0215	cysteine-tRNA ligase activity
AC731_000810	COG0484	heat shock protein binding
AC731_000815	COG0443	Heat shock 70 kDa protein
AC731_000820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AC731_000835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AC731_000845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC731_000850	COG0287	Prephenate dehydrogenase
AC731_000855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AC731_000865	COG0776	regulation of translation
AC731_000875	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AC731_000905	COG2261	transglycosylase associated protein
AC731_000915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AC731_000920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AC731_000925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AC731_000930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AC731_000935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AC731_000940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC731_000940	COG0072	phenylalanine-tRNA ligase activity
AC731_000945	COG0776	regulation of translation
AC731_000960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AC731_000965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC731_000985	COG2951	lytic endotransglycosylase activity
AC731_001000	COG0714	Associated with various cellular activities
AC731_001005	COG0123	including yeast histone deacetylase and acetoin utilization protein
AC731_001010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC731_001015	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AC731_001025	COG2850	peptidyl-arginine hydroxylation
AC731_001030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC731_001050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC731_001055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC731_001070	COG1191	sigma factor activity
AC731_001075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AC731_001080	COG1360	Flagellar Motor Protein
AC731_001090	COG0187	DNA topoisomerase II activity
AC731_001110	COG1815	bacterial-type flagellum-dependent cell motility
AC731_001115	COG1558	bacterial-type flagellum-dependent cell motility
AC731_001120	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AC731_001125	COG1749	Flagellar hook protein flgE
AC731_001130	COG4787	bacterial-type flagellum-dependent cell motility
AC731_001135	COG4786	Flagellar basal body rod
AC731_001140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AC731_001145	COG1706	bacterial-type flagellum-dependent cell motility
AC731_001150	COG1705	Flagellar rod assembly protein muramidase FlgJ
AC731_001150	COG3951	Flagellar rod assembly protein muramidase FlgJ
AC731_001155	COG1256	bacterial-type flagellum assembly
AC731_001175	COG1987	bacterial-type flagellum assembly
AC731_001190	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AC731_001195	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AC731_001215	COG1157	protein secretion by the type III secretion system
AC731_001225	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AC731_001230	COG1766	The M ring may be actively involved in energy transduction
AC731_001235	COG3852	Histidine kinase
AC731_001245	COG1677	Flagellar hook-basal body complex protein FliE
AC731_001260	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AC731_001265	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AC731_001315	COG1216	Glycosyl transferase, family 2
AC731_001325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AC731_001360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC731_001365	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC731_001370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AC731_001385	COG4566	intracellular signal transduction
AC731_001395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC731_001400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AC731_001405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AC731_001410	COG0009	L-threonylcarbamoyladenylate synthase
AC731_001435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC731_001485	COG0732	type I restriction modification DNA specificity domain
AC731_001490	COG1401	restriction endodeoxyribonuclease activity
AC731_001530	COG2176	DNA-directed DNA polymerase activity
AC731_001545	COG0625	glutathione transferase activity
AC731_001565	COG0300	oxidoreductase activity
AC731_001575	COG0745	RESPONSE REGULATOR receiver
AC731_001580	COG0642	Histidine kinase
AC731_001595	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC731_001600	COG0723	plastoquinol--plastocyanin reductase activity
AC731_001615	COG0625	glutathione transferase activity
AC731_001620	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AC731_001625	COG3383	formate dehydrogenase (NAD+) activity
AC731_001630	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
AC731_001635	COG3259	Nickel-dependent hydrogenase
AC731_001670	COG0473	3-isopropylmalate dehydrogenase activity
AC731_001700	COG0583	DNA-binding transcription factor activity
AC731_001720	COG0210	DNA helicase
AC731_001740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AC731_001815	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AC731_001820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC731_001850	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AC731_001865	COG0395	ABC-type sugar transport system, permease component
AC731_001870	COG1175	transmembrane transport
AC731_001875	COG1653	transport
AC731_001880	COG3842	ATPase activity
AC731_001890	COG0438	transferase activity, transferring glycosyl groups
AC731_001900	COG2032	superoxide dismutase activity
AC731_001910	COG0584	glycerophosphoryl diester phosphodiesterase
AC731_001925	COG2951	lytic endotransglycosylase activity
AC731_001930	COG2186	Transcriptional regulator
AC731_001935	COG1620	l-lactate permease
AC731_001940	COG0247	lactate metabolic process
AC731_001960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AC731_001965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AC731_001965	COG2885	chlorophyll binding
AC731_001970	COG0402	S-adenosylhomocysteine deaminase activity
AC731_001975	COG2815	serine threonine protein kinase
AC731_001975	COG0515	serine threonine protein kinase
AC731_001980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AC731_001985	COG1420	regulation of RNA biosynthetic process
AC731_001990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AC731_001995	COG0497	DNA recombination
AC731_002000	COG0735	belongs to the Fur family
AC731_002005	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC731_002010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AC731_002020	COG0505	Belongs to the CarA family
AC731_002025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AC731_002030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC731_002035	COG1534	Rna-binding protein
AC731_002040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AC731_002045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AC731_002050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AC731_002055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC731_002060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AC731_002065	COG0573	inorganic phosphate transmembrane transporter activity
AC731_002070	COG0581	inorganic phosphate transmembrane transporter activity
AC731_002075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC731_002080	COG0149	triose-phosphate isomerase activity
AC731_002095	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC731_002100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC731_002105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC731_002110	COG0649	NAD binding
AC731_002115	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AC731_002125	COG1034	ATP synthesis coupled electron transport
AC731_002130	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AC731_002135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC731_002145	COG0713	ATP synthesis coupled electron transport
AC731_002160	COG1007	ATP synthesis coupled electron transport
AC731_002180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC731_002180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC731_002190	COG2840	Smr protein MutS2
AC731_002195	COG0492	ferredoxin-NADP+ reductase activity
AC731_002205	COG1674	ftsk spoiiie
AC731_002210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AC731_002215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AC731_002225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AC731_002230	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AC731_002235	COG0484	heat shock protein binding
AC731_002255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC731_002260	COG1469	GTP cyclohydrolase I activity
AC731_002265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AC731_002270	COG0142	geranyltranstransferase activity
AC731_002275	COG1722	exodeoxyribonuclease VII activity
AC731_002285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AC731_002290	COG1047	Peptidyl-prolyl cis-trans
AC731_002295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AC731_002300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AC731_002305	COG0196	riboflavin kinase activity
AC731_002310	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC731_002315	COG0802	atpase or kinase
AC731_002350	COG3045	CreA protein
AC731_002360	COG2239	Acts as a magnesium transporter
AC731_002370	COG0826	peptidase U32
AC731_002380	COG2133	pyrroloquinoline quinone binding
AC731_002385	COG0515	serine threonine protein kinase
AC731_002385	COG2815	serine threonine protein kinase
AC731_002395	COG3108	Peptidase M15
AC731_002400	COG2989	Protein conserved in bacteria
AC731_002405	COG0438	transferase activity, transferring glycosyl groups
AC731_002445	COG0640	Transcriptional regulator
AC731_002455	COG0798	PFAM Bile acid sodium symporter
AC731_002530	COG0019	diaminopimelate decarboxylase activity
AC731_002540	COG0840	transmembrane signaling receptor activity
AC731_002545	COG1116	anion transmembrane transporter activity
AC731_002550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC731_002555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC731_002560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC731_002570	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC731_002595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC731_002595	COG1116	anion transmembrane transporter activity
AC731_002620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC731_002625	COG0431	NADPH-dependent FMN reductase
AC731_002635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC731_002640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC731_002645	COG2011	ABC-type metal ion transport system permease component
AC731_002650	COG1464	Belongs to the NlpA lipoprotein family
AC731_002655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AC731_002665	COG0243	molybdopterin cofactor binding
AC731_002710	COG3829	transcription factor binding
AC731_002755	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AC731_002795	COG2081	HI0933 family
AC731_002825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC731_002830	COG0719	Fe-S assembly protein
AC731_002835	COG0396	ATPase activity
AC731_002840	COG0719	Fe-S assembly protein
AC731_002860	COG2363	Small membrane protein
AC731_002865	COG0534	Mate efflux family protein
AC731_002870	COG1490	D-aminoacyl-tRNA deacylase activity
AC731_002880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC731_002910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_002930	COG3706	GGDEF domain
AC731_002935	COG1902	pentaerythritol trinitrate reductase activity
AC731_002940	COG1979	alcohol dehydrogenase
AC731_002945	COG1309	transcriptional regulator
AC731_002950	COG2814	Major facilitator Superfamily
AC731_002955	COG0842	Transport permease protein
AC731_002960	COG1129	ABC transporter
AC731_002960	COG0842	Transport permease protein
AC731_002965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_002970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC731_002975	COG1127	ABC transporter
AC731_002990	COG0587	DNA-directed DNA polymerase activity
AC731_003000	COG4120	Belongs to the binding-protein-dependent transport system permease family
AC731_003005	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AC731_003010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC731_003020	COG2197	response regulator
AC731_003030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC731_003030	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AC731_003035	COG2354	Protein conserved in bacteria
AC731_003040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AC731_003055	COG1196	nuclear chromosome segregation
AC731_003070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AC731_003100	COG1278	Cold shock
AC731_003105	COG1032	radical SAM domain protein
AC731_003120	COG1136	(ABC) transporter
AC731_003160	COG0501	Belongs to the peptidase M48B family
AC731_003165	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AC731_003175	COG0254	rRNA binding
AC731_003185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC731_003190	COG3318	Belongs to the UPF0149 family
AC731_003190	COG3012	SEC-C Motif Domain Protein
AC731_003220	COG3012	SEC-C Motif Domain Protein
AC731_003230	COG5001	Diguanylate cyclase
AC731_003230	COG3447	MASE1 domain protein
AC731_003230	COG5002	protein histidine kinase activity
AC731_003240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC731_003250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AC731_003255	COG4215	(ABC) transporter
AC731_003260	COG4160	amino acid transport
AC731_003270	COG2814	Major facilitator Superfamily
AC731_003275	COG0583	DNA-binding transcription factor activity
AC731_003285	COG0039	L-malate dehydrogenase activity
AC731_003305	COG1053	succinate dehydrogenase
AC731_003310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AC731_003315	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AC731_003320	COG0372	Belongs to the citrate synthase family
AC731_003325	COG0567	Dehydrogenase, E1 component
AC731_003330	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC731_003335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC731_003340	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AC731_003405	COG1199	ATP-dependent helicase activity
AC731_003415	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AC731_003420	COG0415	Belongs to the DNA photolyase family
AC731_003425	COG0415	Belongs to the DNA photolyase family
AC731_003505	COG1222	aaa ATPase
AC731_003555	COG4974	Belongs to the 'phage' integrase family
AC731_003655	COG0517	IMP dehydrogenase activity
AC731_003660	COG4974	Belongs to the 'phage' integrase family
AC731_003670	COG3316	Transposase and inactivated derivatives
AC731_003680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC731_003695	COG1763	Mo-molybdopterin cofactor biosynthetic process
AC731_003700	COG0303	'Molybdopterin
AC731_003705	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AC731_003710	COG0314	molybdopterin synthase activity
AC731_003725	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AC731_003730	COG1704	LemA family
AC731_003765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AC731_003770	COG0590	tRNA wobble adenosine to inosine editing
AC731_003775	COG1376	ErfK ybiS ycfS ynhG family protein
AC731_003780	COG2153	protein acetylation
AC731_003785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AC731_003800	COG0354	folic acid binding
AC731_003805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AC731_003810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC731_003825	COG0084	hydrolase, TatD family'
AC731_003835	COG0513	Belongs to the DEAD box helicase family
AC731_003840	COG2824	Alkylphosphonate utilization operon protein PhnA
AC731_003855	COG0728	peptidoglycan biosynthetic process
AC731_003860	COG0268	Binds directly to 16S ribosomal RNA
AC731_003870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC731_003875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AC731_003880	COG0137	argininosuccinate synthase activity
AC731_003890	COG3123	guanosine phosphorylase activity
AC731_003895	COG1666	GTP binding
AC731_003955	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC731_003960	COG0183	Belongs to the thiolase family
AC731_003965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC731_003975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AC731_003990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC731_004000	COG5002	protein histidine kinase activity
AC731_004005	COG0745	RESPONSE REGULATOR receiver
AC731_004010	COG2176	DNA-directed DNA polymerase activity
AC731_004010	COG5002	protein histidine kinase activity
AC731_004015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC731_004020	COG5001	Diguanylate cyclase
AC731_004020	COG3300	MHYT domain
AC731_004025	COG3852	Histidine kinase
AC731_004030	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_004035	COG0542	response to heat
AC731_004045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC731_004060	COG0601	transmembrane transport
AC731_004065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC731_004070	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AC731_004075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC731_004085	COG2914	Belongs to the UPF0125 (RnfH) family
AC731_004100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC731_004100	COG0519	Catalyzes the synthesis of GMP from XMP
AC731_004125	COG4680	protein conserved in bacteria
AC731_004135	COG2194	sulfuric ester hydrolase activity
AC731_004140	COG0058	SHG alpha-glucan phosphorylase activity
AC731_004145	COG0297	glycogen (starch) synthase activity
AC731_004150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AC731_004155	COG0033	Phosphoglucomutase
AC731_004160	COG1523	belongs to the glycosyl hydrolase 13 family
AC731_004170	COG0166	Belongs to the GPI family
AC731_004175	COG0837	glucose binding
AC731_004180	COG1640	4-alpha-glucanotransferase
AC731_004210	COG1959	2 iron, 2 sulfur cluster binding
AC731_004215	COG1309	transcriptional regulator
AC731_004230	COG1136	(ABC) transporter
AC731_004235	COG1944	ATP diphosphatase activity
AC731_004240	COG2186	Transcriptional regulator
AC731_004245	COG0277	FAD linked oxidase domain protein
AC731_004250	COG0277	FAD linked oxidase domain protein
AC731_004255	COG0247	lactate metabolic process
AC731_004260	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AC731_004265	COG1620	l-lactate permease
AC731_004290	COG0435	Glutathione S-transferase
AC731_004295	COG0583	DNA-binding transcription factor activity
AC731_004300	COG3384	dioxygenase
AC731_004305	COG0400	carboxylic ester hydrolase activity
AC731_004380	COG0582	viral genome integration into host DNA
AC731_004385	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AC731_004395	COG0850	regulation of cytokinetic process
AC731_004400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AC731_004405	COG1393	Belongs to the ArsC family
AC731_004410	COG2183	response to ionizing radiation
AC731_004420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AC731_004420	COG0045	succinate-CoA ligase (ADP-forming) activity
AC731_004420	COG1042	CoA-binding domain protein
AC731_004425	COG2202	Pas domain
AC731_004425	COG2205	protein histidine kinase activity
AC731_004435	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AC731_004450	COG4181	ATPase activity
AC731_004455	COG0560	Phosphoserine phosphatase
AC731_004460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC731_004465	COG0598	Magnesium transport protein CorA
AC731_004470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AC731_004495	COG2078	PFAM AMMECR1 domain protein
AC731_004500	COG1355	regulation of microtubule-based process
AC731_004505	COG3174	membrane
AC731_004510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AC731_004515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AC731_004530	COG0655	NAD(P)H dehydrogenase (quinone) activity
AC731_004535	COG3228	Belongs to the MtfA family
AC731_004540	COG0697	spore germination
AC731_004545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC731_004550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AC731_004555	COG0248	Ppx GppA phosphatase
AC731_004560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC731_004565	COG1127	ABC transporter
AC731_004585	COG0084	hydrolase, TatD family'
AC731_004590	COG1309	transcriptional regulator
AC731_004610	COG1960	acyl-CoA dehydrogenase activity
AC731_004615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC731_004625	COG2350	Protein conserved in bacteria
AC731_004630	COG2917	probably involved in intracellular septation
AC731_004640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC731_004650	COG0745	RESPONSE REGULATOR receiver
AC731_004665	COG1573	uracil-dna glycosylase
AC731_004670	COG0477	Major facilitator Superfamily
AC731_004675	COG0583	DNA-binding transcription factor activity
AC731_004685	COG4772	TonB-dependent receptor
AC731_004700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AC731_004705	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AC731_004715	COG0535	radical SAM domain protein
AC731_004720	COG2197	response regulator
AC731_004750	COG1131	(ABC) transporter
AC731_004840	COG0702	epimerase
AC731_004845	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
AC731_004855	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
AC731_004910	COG1229	Formylmethanofuran dehydrogenase subunit A
AC731_004915	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
AC731_004945	COG3284	Transcriptional regulator
AC731_004955	COG0242	peptide deformylase activity
AC731_004970	COG0662	Cupin 2, conserved barrel domain protein
AC731_004970	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AC731_004975	COG1091	dTDP-4-dehydrorhamnose reductase activity
AC731_005000	COG1562	ergosterol biosynthetic process
AC731_005010	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AC731_005015	COG2866	Carboxypeptidase
AC731_005020	COG3022	response to hydroperoxide
AC731_005030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC731_005035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AC731_005040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC731_005045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC731_005050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC731_005055	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC731_005075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AC731_005080	COG0575	Belongs to the CDS family
AC731_005085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC731_005090	COG0233	cytoplasmic translational termination
AC731_005095	COG0528	UMP kinase activity
AC731_005100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AC731_005105	COG0052	Belongs to the universal ribosomal protein uS2 family
AC731_005110	COG0024	Methionine aminopeptidase
AC731_005115	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AC731_005120	COG2862	Uncharacterized protein family, UPF0114
AC731_005140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AC731_005150	COG1196	nuclear chromosome segregation
AC731_005155	COG0436	Aminotransferase
AC731_005160	COG2171	N-acyltransferase activity
AC731_005170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC731_005180	COG2201	protein-glutamate methylesterase activity
AC731_005190	COG0633	Ferredoxin
AC731_005195	COG0443	Heat shock 70 kDa protein
AC731_005200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AC731_005210	COG0822	iron-sulfur transferase activity
AC731_005215	COG1104	cysteine desulfurase activity
AC731_005220	COG1104	cysteine desulfurase activity
AC731_005230	COG1045	serine acetyltransferase
AC731_005420	COG1783	phage Terminase large subunit
AC731_005470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC731_005520	COG0419	ATPase involved in DNA repair
AC731_005565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AC731_005580	COG0517	IMP dehydrogenase activity
AC731_005585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC731_005590	COG0328	RNA-DNA hybrid ribonuclease activity
AC731_005600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC731_005605	COG2197	response regulator
AC731_005610	COG0741	lytic transglycosylase activity
AC731_005610	COG1388	LysM domain
AC731_005620	COG1047	Peptidyl-prolyl cis-trans
AC731_005635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC731_005655	COG0534	Mate efflux family protein
AC731_005675	COG4628	conserved protein (DUF2132)
AC731_005680	COG3040	lipid binding
AC731_005685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC731_005700	COG3005	denitrification pathway
AC731_005715	COG2203	Gaf domain
AC731_005715	COG5001	Diguanylate cyclase
AC731_005715	COG4251	negative regulation of phosphorylation
AC731_005715	COG3706	GGDEF domain
AC731_005735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC731_005740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC731_005770	COG0589	response to stress
AC731_005770	COG0475	glutathione-regulated potassium exporter activity
AC731_005810	COG3135	benzoate transporter
AC731_005830	COG3384	dioxygenase
AC731_005840	COG0861	Integral membrane protein TerC family
AC731_005845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AC731_005855	COG1858	cytochrome C peroxidase
AC731_005870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AC731_005875	COG0745	RESPONSE REGULATOR receiver
AC731_005880	COG5002	protein histidine kinase activity
AC731_005885	COG2194	sulfuric ester hydrolase activity
AC731_005940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AC731_005945	COG0671	phosphoesterase, PA-phosphatase related
AC731_005960	COG2204	response regulator
AC731_005970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AC731_006045	COG0582	viral genome integration into host DNA
AC731_006060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AC731_006065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC731_006070	COG0740	serine-type endopeptidase activity
AC731_006075	COG0544	peptidyl-prolyl cis-trans isomerase activity
AC731_006080	COG2766	serine protein kinase
AC731_006085	COG2718	Belongs to the UPF0229 family
AC731_006090	COG2719	SpoVR family
AC731_006095	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AC731_006095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC731_006105	COG0697	spore germination
AC731_006130	COG3360	Dodecin
AC731_006135	COG2258	MOSC domain
AC731_006145	COG0436	Aminotransferase
AC731_006155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AC731_006160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AC731_006175	COG0791	NLP P60 protein
AC731_006185	COG1840	ABC-type Fe3 transport system, periplasmic component
AC731_006190	COG0745	RESPONSE REGULATOR receiver
AC731_006190	COG3706	GGDEF domain
AC731_006195	COG1178	ABC-type Fe3 transport system permease component
AC731_006200	COG3842	ATPase activity
AC731_006205	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AC731_006210	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AC731_006215	COG0167	dihydroorotate dehydrogenase activity
AC731_006230	COG2010	Cytochrome c
AC731_006240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC731_006245	COG3706	GGDEF domain
AC731_006290	COG2200	EAL domain
AC731_006330	COG3391	amine dehydrogenase activity
AC731_006355	COG2010	Cytochrome c
AC731_006525	COG1783	phage Terminase large subunit
AC731_006575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC731_006625	COG2974	May be involved in recombination
AC731_006630	COG0419	ATPase involved in DNA repair
AC731_006695	COG0322	excinuclease ABC activity
AC731_006700	COG1472	Belongs to the glycosyl hydrolase 3 family
AC731_006705	COG0736	holo-[acyl-carrier-protein] synthase activity
AC731_006710	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AC731_006715	COG1381	Involved in DNA repair and RecF pathway recombination
AC731_006720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AC731_006725	COG0571	ribonuclease III activity
AC731_006735	COG0681	Belongs to the peptidase S26 family
AC731_006740	COG0481	GTPase activity
AC731_006750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC731_006775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AC731_006785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AC731_006790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC731_006800	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC731_006805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC731_006810	COG0416	fatty acid biosynthetic process
AC731_006815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AC731_006825	COG0424	maF-like protein
AC731_006830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AC731_006840	COG0564	pseudouridine synthase activity
AC731_006845	COG1530	ribonuclease E activity
AC731_006850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC731_006855	COG0556	nucleotide-excision repair
AC731_006880	COG2205	protein histidine kinase activity
AC731_006880	COG0784	Response regulator, receiver
AC731_006880	COG2198	Histidine kinase
AC731_006895	COG3647	Membrane
AC731_006905	COG1067	ATP-dependent peptidase activity
AC731_006910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AC731_006935	COG0438	transferase activity, transferring glycosyl groups
AC731_006955	COG0776	regulation of translation
AC731_007000	COG3267	Type II secretory pathway component ExeA
AC731_007000	COG3409	Peptidoglycan-binding domain 1 protein
AC731_007100	COG4373	Mu-like prophage FluMu protein gp28
AC731_007220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC731_007245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AC731_007250	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AC731_007255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_007270	COG0583	DNA-binding transcription factor activity
AC731_007285	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AC731_007290	COG1473	amidohydrolase
AC731_007295	COG0583	DNA-binding transcription factor activity
AC731_007305	COG0386	Belongs to the glutathione peroxidase family
AC731_007310	COG0488	(ABC) transporter
AC731_007325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC731_007330	COG1185	polyribonucleotide nucleotidyltransferase activity
AC731_007335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AC731_007340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AC731_007345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AC731_007350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AC731_007355	COG2251	uridine kinase activity
AC731_007355	COG0195	Participates in both transcription termination and antitermination
AC731_007360	COG0779	Required for maturation of 30S ribosomal subunits
AC731_007365	COG1187	pseudouridine synthase activity
AC731_007370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AC731_007375	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AC731_007380	COG1994	Peptidase M50
AC731_007385	COG0009	L-threonylcarbamoyladenylate synthase
AC731_007390	COG0613	PHP domain protein
AC731_007395	COG2267	carboxylic ester hydrolase activity
AC731_007405	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AC731_007410	COG1278	Cold shock
AC731_007435	COG4681	YaeQ
AC731_007450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AC731_007460	COG0302	gtp cyclohydrolase
AC731_007470	COG0306	phosphate transporter
AC731_007480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AC731_007505	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AC731_007510	COG0148	phosphopyruvate hydratase activity
AC731_007515	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AC731_007520	COG0504	CTP synthase activity
AC731_007530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC731_007535	COG0824	Thioesterase
AC731_007565	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AC731_007570	COG0047	phosphoribosylformylglycinamidine synthase activity
AC731_007570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC731_007580	COG1484	DNA-dependent DNA replication
AC731_007585	COG4584	PFAM Integrase catalytic
AC731_007620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC731_007625	COG0509	glycine decarboxylation via glycine cleavage system
AC731_007630	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC731_007630	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC731_007640	COG1215	transferase activity, transferring glycosyl groups
AC731_007645	COG0471	metal ion transport
AC731_007655	COG0563	adenylate kinase activity
AC731_007660	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AC731_007665	COG2835	tetraacyldisaccharide 4'-kinase activity
AC731_007670	COG1663	tetraacyldisaccharide 4'-kinase activity
AC731_007675	COG0848	biopolymer transport protein
AC731_007680	COG0811	peptide transport
AC731_007685	COG1570	exodeoxyribonuclease VII activity
AC731_007690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AC731_007695	COG0564	pseudouridine synthase activity
AC731_007700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AC731_007705	COG0643	Histidine kinase
AC731_007705	COG2198	Histidine kinase
AC731_007710	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AC731_007715	COG0745	RESPONSE REGULATOR receiver
AC731_007720	COG0835	chemotaxis
AC731_007720	COG0784	Response regulator, receiver
AC731_007725	COG0784	Response regulator, receiver
AC731_007725	COG0835	chemotaxis
AC731_007735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AC731_007750	COG3706	GGDEF domain
AC731_007750	COG0745	RESPONSE REGULATOR receiver
AC731_007760	COG4657	Part of a membrane complex involved in electron transport
AC731_007765	COG2878	Part of a membrane complex involved in electron transport
AC731_007770	COG4656	Part of a membrane complex involved in electron transport
AC731_007780	COG4659	FMN binding
AC731_007790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AC731_007805	COG0745	RESPONSE REGULATOR receiver
AC731_007825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AC731_007835	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_007840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_007860	COG5002	protein histidine kinase activity
AC731_007870	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AC731_007875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AC731_007890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AC731_007905	COG2814	Major facilitator Superfamily
AC731_007920	COG3706	GGDEF domain
AC731_007920	COG0745	RESPONSE REGULATOR receiver
AC731_007925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AC731_007930	COG3383	formate dehydrogenase (NAD+) activity
AC731_007945	COG0583	DNA-binding transcription factor activity
AC731_007960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_007965	COG1363	Peptidase, m42
AC731_007970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC731_007970	COG0189	ligase activity
AC731_007985	COG2226	methyltransferase
AC731_007990	COG2205	protein histidine kinase activity
AC731_007990	COG2198	Histidine kinase
AC731_007990	COG0784	Response regulator, receiver
AC731_007995	COG0784	Response regulator, receiver
AC731_007995	COG5002	protein histidine kinase activity
AC731_008005	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AC731_008010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC731_008015	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC731_008025	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_008035	COG0840	transmembrane signaling receptor activity
AC731_008050	COG2086	electron transfer activity
AC731_008060	COG1902	pentaerythritol trinitrate reductase activity
AC731_008075	COG1960	acyl-CoA dehydrogenase activity
AC731_008090	COG2207	Transcriptional regulator
AC731_008095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC731_008110	COG1309	transcriptional regulator
AC731_008115	COG0183	Belongs to the thiolase family
AC731_008120	COG1024	Enoyl-CoA hydratase
AC731_008120	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC731_008130	COG1960	acyl-CoA dehydrogenase activity
AC731_008135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC731_008140	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_008150	COG0786	glutamate:sodium symporter activity
AC731_008155	COG0010	Belongs to the arginase family
AC731_008175	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_008180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC731_008195	COG1012	belongs to the aldehyde dehydrogenase family
AC731_008205	COG0778	Nitroreductase
AC731_008210	COG1024	Enoyl-CoA hydratase
AC731_008225	COG1309	transcriptional regulator
AC731_008230	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_008235	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_008245	COG0641	radical SAM
AC731_008250	COG3119	arylsulfatase activity
AC731_008255	COG0714	Associated with various cellular activities
AC731_008275	COG2304	oxidoreductase activity
AC731_008300	COG1960	acyl-CoA dehydrogenase activity
AC731_008305	COG1960	acyl-CoA dehydrogenase activity
AC731_008310	COG0183	Belongs to the thiolase family
AC731_008320	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_008360	COG4266	Belongs to the allantoicase family
AC731_008370	COG0235	Class ii aldolase
AC731_008375	COG1942	4-Oxalocrotonate Tautomerase
AC731_008380	COG2233	PERMEase
AC731_008390	COG4566	intracellular signal transduction
AC731_008400	COG0697	spore germination
AC731_008405	COG0583	DNA-binding transcription factor activity
AC731_008415	COG3960	tartronate-semialdehyde synthase activity
AC731_008420	COG3622	Belongs to the hyi family
AC731_008425	COG2084	Dehydrogenase
AC731_008440	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AC731_008445	COG0469	pyruvate kinase activity
AC731_008455	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_008460	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_008470	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_008475	COG0183	Belongs to the thiolase family
AC731_008480	COG1960	acyl-CoA dehydrogenase activity
AC731_008485	COG1960	acyl-CoA dehydrogenase activity
AC731_008500	COG1024	Enoyl-CoA hydratase
AC731_008580	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_008585	COG2814	Major facilitator Superfamily
AC731_008595	COG1902	pentaerythritol trinitrate reductase activity
AC731_008595	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC731_008620	COG1595	DNA-templated transcription, initiation
AC731_008625	COG0431	NADPH-dependent FMN reductase
AC731_008650	COG0778	Nitroreductase
AC731_008650	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AC731_008670	COG0175	sulfate reduction
AC731_008680	COG1218	3'(2'),5'-bisphosphate nucleotidase
AC731_008700	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_008705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC731_008715	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_008740	COG1960	acyl-CoA dehydrogenase activity
AC731_008745	COG1960	acyl-CoA dehydrogenase activity
AC731_008750	COG1960	acyl-CoA dehydrogenase activity
AC731_008765	COG1960	acyl-CoA dehydrogenase activity
AC731_008795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC731_008810	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_008820	COG0300	oxidoreductase activity
AC731_008830	COG1902	pentaerythritol trinitrate reductase activity
AC731_008830	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC731_008880	COG1012	belongs to the aldehyde dehydrogenase family
AC731_008885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC731_008900	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AC731_008905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC731_008955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC731_008990	COG4974	Belongs to the 'phage' integrase family
AC731_009015	COG3293	Transposase
AC731_009025	COG3344	reverse transcriptase
AC731_009030	COG2801	Transposase and inactivated derivatives
AC731_009075	COG0720	synthase
AC731_009080	COG2860	membrane
AC731_009085	COG1473	amidohydrolase
AC731_009105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC731_009110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC731_009110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AC731_009120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AC731_009130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AC731_009135	COG1238	metal cluster binding
AC731_009150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AC731_009160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_009165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_009210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AC731_009215	COG0628	permease
AC731_009220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AC731_009230	COG0617	tRNA 3'-terminal CCA addition
AC731_009245	COG1428	Deoxynucleoside kinase
AC731_009250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AC731_009255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AC731_009260	COG0517	IMP dehydrogenase activity
AC731_009260	COG0516	GMP reductase activity
AC731_009265	COG0308	aminopeptidase N
AC731_009275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC731_009275	COG4651	solute:proton antiporter activity
AC731_009290	COG0028	Belongs to the TPP enzyme family
AC731_009295	COG0440	acetolactate synthase activity
AC731_009300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC731_009305	COG1183	phosphatidylcholine synthase activity
AC731_009310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC731_009325	COG1295	ribonuclease BN
AC731_009335	COG0228	four-way junction DNA binding
AC731_009340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AC731_009345	COG0336	Belongs to the RNA methyltransferase TrmD family
AC731_009350	COG0335	large ribosomal subunit rRNA binding
AC731_009360	COG0795	lipopolysaccharide-transporting ATPase activity
AC731_009365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC731_009380	COG0525	valine-tRNA ligase activity
AC731_009385	COG0425	Belongs to the sulfur carrier protein TusA family
AC731_009390	COG4783	chaperone-mediated protein folding
AC731_009395	COG0315	cyclic pyranopterin monophosphate synthase activity
AC731_009525	COG5002	protein histidine kinase activity
AC731_009530	COG0745	RESPONSE REGULATOR receiver
AC731_009545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC731_009570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC731_009575	COG2414	aldehyde ferredoxin oxidoreductase
AC731_009585	COG3284	Transcriptional regulator
AC731_009595	COG1012	belongs to the aldehyde dehydrogenase family
AC731_009635	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AC731_009645	COG0156	8-amino-7-oxononanoate synthase activity
AC731_009650	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AC731_009655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AC731_009660	COG2124	cytochrome p450
AC731_009665	COG0443	Heat shock 70 kDa protein
AC731_009705	COG0583	DNA-binding transcription factor activity
AC731_009715	COG0628	permease
AC731_009730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC731_009740	COG1879	ABC-type sugar transport system periplasmic component
AC731_009745	COG0784	Response regulator, receiver
AC731_009745	COG2198	Histidine kinase
AC731_009745	COG2205	protein histidine kinase activity
AC731_009760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC731_009765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AC731_009770	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AC731_009780	COG0521	Mo-molybdopterin cofactor biosynthetic process
AC731_009785	COG3028	Belongs to the UPF0307 family
AC731_009790	COG0312	modulator of DNA gyrase
AC731_009795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AC731_009800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AC731_009810	COG0406	alpha-ribazole phosphatase activity
AC731_009815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AC731_009830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC731_009835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AC731_009840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC731_009840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC731_009845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AC731_009855	COG0793	Belongs to the peptidase S41A family
AC731_009865	COG0640	Transcriptional regulator
AC731_009870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC731_009880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AC731_009890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AC731_009895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AC731_009905	COG2226	methyltransferase
AC731_009925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AC731_009935	COG1333	cytochrome c biogenesis protein
AC731_009940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC731_009945	COG2833	Protein of unknown function (DUF455)
AC731_009955	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AC731_009960	COG0704	Plays a role in the regulation of phosphate uptake
AC731_009965	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AC731_009975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC731_009975	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AC731_009985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AC731_009990	COG0483	inositol monophosphate 1-phosphatase activity
AC731_009995	COG3954	Phosphoribulokinase
AC731_010000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AC731_010005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC731_010010	COG0126	phosphoglycerate kinase activity
AC731_010045	COG0583	DNA-binding transcription factor activity
AC731_010065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AC731_010070	COG3954	Phosphoribulokinase
AC731_010080	COG0126	phosphoglycerate kinase activity
AC731_010085	COG0191	fructose-bisphosphate aldolase activity
AC731_010095	COG3485	protocatechuate 3,4-dioxygenase
AC731_010105	COG2818	Glycosylase
AC731_010110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AC731_010130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC731_010140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AC731_010145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AC731_010150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC731_010155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AC731_010165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AC731_010170	COG0006	proline dipeptidase activity
AC731_010175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC731_010185	COG2011	ABC-type metal ion transport system permease component
AC731_010200	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AC731_010205	COG0138	bifunctional purine biosynthesis protein purh
AC731_010210	COG0151	Belongs to the GarS family
AC731_010215	COG3422	double-strand break repair
AC731_010220	COG0408	coproporphyrinogen oxidase activity
AC731_010230	COG2959	enzyme of heme biosynthesis
AC731_010240	COG0181	hydroxymethylbilane synthase activity
AC731_010250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AC731_010260	COG3275	phosphorelay sensor kinase activity
AC731_010265	COG0165	Argininosuccinate lyase
AC731_010270	COG2815	serine threonine protein kinase
AC731_010270	COG0515	serine threonine protein kinase
AC731_010300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC731_010305	COG2890	protein-(glutamine-N5) methyltransferase activity
AC731_010310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AC731_010315	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AC731_010360	COG0642	Histidine kinase
AC731_010365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC731_010370	COG3162	membrane
AC731_010375	COG0642	Histidine kinase
AC731_010380	COG0745	RESPONSE REGULATOR receiver
AC731_010385	COG0459	protein refolding
AC731_010390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AC731_010410	COG0471	metal ion transport
AC731_010410	COG3273	potassium ion transport
AC731_010415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC731_010425	COG0604	alcohol dehydrogenase
AC731_010435	COG1704	LemA family
AC731_010480	COG2204	response regulator
AC731_010485	COG3852	Histidine kinase
AC731_010490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AC731_010495	COG2030	dehydratase
AC731_010530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AC731_010540	COG1982	Orn Lys Arg decarboxylase major
AC731_010545	COG0717	Belongs to the dCTP deaminase family
AC731_010550	COG0489	protein tyrosine kinase activity
AC731_010560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC731_010560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC731_010565	COG0659	secondary active sulfate transmembrane transporter activity
AC731_010570	COG1254	Belongs to the acylphosphatase family
AC731_010575	COG0668	transmembrane transport
AC731_010590	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AC731_010600	COG1192	Involved in chromosome partitioning
AC731_010605	COG0210	DNA helicase
AC731_010615	COG0495	leucyl-tRNA aminoacylation
AC731_010625	COG1466	dna polymerase III delta subunit
AC731_010630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AC731_010645	COG4974	Belongs to the 'phage' integrase family
AC731_010650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AC731_010665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AC731_010670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AC731_010690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AC731_010700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC731_010745	COG4964	Belongs to the GSP D family
AC731_010780	COG3209	COG3209 Rhs family protein
AC731_010810	COG0604	alcohol dehydrogenase
AC731_010815	COG2070	2-Nitropropane dioxygenase
AC731_010840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AC731_010860	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AC731_010875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AC731_010895	COG0071	Belongs to the small heat shock protein (HSP20) family
AC731_010900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC731_010925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC731_010930	COG3338	carbonate dehydratase activity
AC731_010935	COG0351	phosphomethylpyrimidine kinase
AC731_010940	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AC731_010945	COG1063	alcohol dehydrogenase
AC731_010955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC731_010960	COG0668	transmembrane transport
AC731_010965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC731_010975	COG1715	Restriction endonuclease
AC731_010980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_010985	COG1136	(ABC) transporter
AC731_010985	COG0577	efflux transmembrane transporter activity
AC731_010990	COG1136	(ABC) transporter
AC731_010990	COG0577	efflux transmembrane transporter activity
AC731_010995	COG1136	(ABC) transporter
AC731_010995	COG0577	efflux transmembrane transporter activity
AC731_011005	COG2111	Na H antiporter
AC731_011005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC731_011025	COG2212	antiporter activity
AC731_011030	COG1320	monovalent cation:proton antiporter activity
AC731_011035	COG1187	pseudouridine synthase activity
AC731_011045	COG2212	antiporter activity
AC731_011050	COG1863	multisubunit Na H antiporter MnhE subunit
AC731_011055	COG0651	ATP synthesis coupled electron transport
AC731_011060	COG1006	Multisubunit Na H antiporter MnhC subunit
AC731_011065	COG2111	Na H antiporter
AC731_011065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC731_011070	COG1414	Transcriptional regulator
AC731_011085	COG0281	malic enzyme
AC731_011085	COG0280	phosphate acetyltransferase
AC731_011090	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AC731_011095	COG0436	Aminotransferase
AC731_011100	COG0741	lytic transglycosylase activity
AC731_011115	COG0175	sulfate reduction
AC731_011120	COG1218	3'(2'),5'-bisphosphate nucleotidase
AC731_011125	COG0471	metal ion transport
AC731_011125	COG3273	potassium ion transport
AC731_011130	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_011170	COG1696	Membrane protein involved in D-alanine export
AC731_011185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC731_011225	COG1216	Glycosyl transferase, family 2
AC731_011230	COG1216	Glycosyl transferase, family 2
AC731_011255	COG0438	transferase activity, transferring glycosyl groups
AC731_011275	COG0367	asparagine synthase
AC731_011280	COG0438	transferase activity, transferring glycosyl groups
AC731_011310	COG3267	Type II secretory pathway component ExeA
AC731_011310	COG3409	Peptidoglycan-binding domain 1 protein
AC731_011320	COG0489	protein tyrosine kinase activity
AC731_011335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC731_011355	COG0436	Aminotransferase
AC731_011360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AC731_011365	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AC731_011365	COG0235	Class ii aldolase
AC731_011370	COG2084	Dehydrogenase
AC731_011375	COG2084	Dehydrogenase
AC731_011380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC731_011395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AC731_011405	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AC731_011435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AC731_011445	COG0629	single-stranded DNA binding
AC731_011450	COG2814	Major facilitator Superfamily
AC731_011460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AC731_011465	COG0203	ribosomal protein L17
AC731_011470	COG0202	RNA polymerase activity
AC731_011475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AC731_011480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AC731_011485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AC731_011490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AC731_011495	COG0201	protein transport
AC731_011500	COG0200	Binds to the 23S rRNA
AC731_011505	COG1841	ribosomal large subunit assembly
AC731_011510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AC731_011515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AC731_011520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AC731_011525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AC731_011530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AC731_011535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AC731_011540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AC731_011545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AC731_011550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AC731_011555	COG0255	Belongs to the universal ribosomal protein uL29 family
AC731_011560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AC731_011565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AC731_011570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AC731_011575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AC731_011580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AC731_011585	COG0089	rRNA binding
AC731_011590	COG0088	Forms part of the polypeptide exit tunnel
AC731_011595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AC731_011600	COG0051	transcription antitermination factor activity, RNA binding
AC731_011605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC731_011610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC731_011615	COG0049	tRNA binding
AC731_011620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AC731_011625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AC731_011630	COG0085	RNA polymerase activity
AC731_011635	COG0222	ribosome binding
AC731_011640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AC731_011645	COG0081	regulation of translation
AC731_011650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AC731_011660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AC731_011670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC731_011705	COG2197	response regulator
AC731_011715	COG2205	protein histidine kinase activity
AC731_011715	COG0784	Response regulator, receiver
AC731_011715	COG2198	Histidine kinase
AC731_011750	COG0559	Belongs to the binding-protein-dependent transport system permease family
AC731_011760	COG1022	Amp-dependent synthetase and ligase
AC731_011780	COG0840	transmembrane signaling receptor activity
AC731_011785	COG1703	isobutyryl-CoA mutase activity
AC731_011785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AC731_011785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AC731_011810	COG2321	neutral zinc metallopeptidase
AC731_011815	COG1509	lysine 2,3-aminomutase activity
AC731_011820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC731_011820	COG2111	Na H antiporter
AC731_011825	COG1006	Multisubunit Na H antiporter MnhC subunit
AC731_011830	COG0651	ATP synthesis coupled electron transport
AC731_011835	COG1863	multisubunit Na H antiporter MnhE subunit
AC731_011840	COG2212	antiporter activity
AC731_011850	COG0439	Biotin carboxylase
AC731_011855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC731_011860	COG1703	isobutyryl-CoA mutase activity
AC731_011865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AC731_011865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AC731_011870	COG1802	Transcriptional regulator
AC731_011875	COG1253	flavin adenine dinucleotide binding
AC731_011880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC731_011885	COG3162	membrane
AC731_011890	COG1024	Enoyl-CoA hydratase
AC731_011905	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AC731_011910	COG2274	protein secretion by the type I secretion system
AC731_011920	COG2197	response regulator
AC731_011955	COG1136	(ABC) transporter
AC731_011965	COG0735	belongs to the Fur family
AC731_011975	COG1121	(ABC) transporter
AC731_011980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AC731_011985	COG0803	Belongs to the bacterial solute-binding protein 9 family
AC731_012000	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AC731_012010	COG0129	dihydroxy-acid dehydratase activity
AC731_012015	COG3132	Protein of unknown function, DUF480
AC731_012020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC731_012030	COG5001	Diguanylate cyclase
AC731_012075	COG1858	cytochrome C peroxidase
AC731_012080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_012085	COG1136	(ABC) transporter
AC731_012085	COG0577	efflux transmembrane transporter activity
AC731_012095	COG4774	siderophore transport
AC731_012110	COG3128	pkhd-type hydroxylase
AC731_012120	COG1116	anion transmembrane transporter activity
AC731_012135	COG4206	TonB-dependent receptor
AC731_012145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AC731_012165	COG0745	RESPONSE REGULATOR receiver
AC731_012170	COG4191	Histidine kinase
AC731_012170	COG0784	Response regulator, receiver
AC731_012175	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_012180	COG0659	secondary active sulfate transmembrane transporter activity
AC731_012195	COG2119	membrane
AC731_012200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_012220	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AC731_012245	COG4178	(ABC) transporter
AC731_012260	COG1132	(ABC) transporter
AC731_012265	COG3634	alkyl hydroperoxide reductase activity
AC731_012275	COG2177	Part of the ABC transporter FtsEX involved in
AC731_012280	COG2884	Cell division ATP-binding protein ftsE
AC731_012290	COG0612	Peptidase, M16
AC731_012295	COG0612	Peptidase, M16
AC731_012300	COG0742	ribosomal rna small subunit methyltransferase
AC731_012305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AC731_012310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC731_012315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AC731_012320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC731_012330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AC731_012335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AC731_012345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC731_012350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AC731_012355	COG0193	aminoacyl-tRNA hydrolase activity
AC731_012365	COG0012	GTP binding
AC731_012370	COG3344	reverse transcriptase
AC731_012395	COG4263	nitrous-oxide reductase activity
AC731_012445	COG3245	cytochrome
AC731_012450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC731_012455	COG1832	CoA-binding protein
AC731_012460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC731_012465	COG3568	Endonuclease Exonuclease Phosphatase
AC731_012470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AC731_012480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AC731_012495	COG3852	Histidine kinase
AC731_012505	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AC731_012505	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AC731_012510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AC731_012515	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AC731_012525	COG0237	dephospho-CoA kinase activity
AC731_012530	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AC731_012535	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AC731_012540	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AC731_012540	COG0352	thiamine-phosphate diphosphorylase activity
AC731_012555	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AC731_012560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC731_012565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC731_012595	COG0305	Participates in initiation and elongation during chromosome replication
AC731_012600	COG0359	binds to the 23S rRNA
AC731_012605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AC731_012610	COG2965	DNA replication, synthesis of RNA primer
AC731_012615	COG0360	Binds together with S18 to 16S ribosomal RNA
AC731_012625	COG1643	Atp-dependent helicase
AC731_012640	COG1968	undecaprenyl-diphosphatase activity
AC731_012645	COG3150	esterase
AC731_012650	COG2226	methyltransferase
AC731_012660	COG0557	exoribonuclease II activity
AC731_012670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC731_012675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC731_012680	COG2239	Acts as a magnesium transporter
AC731_012685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC731_012690	COG0352	thiamine-phosphate diphosphorylase activity
AC731_012695	COG0351	phosphomethylpyrimidine kinase
AC731_012715	COG0835	chemotaxis
AC731_012720	COG0840	transmembrane signaling receptor activity
AC731_012730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AC731_012735	COG0415	Belongs to the DNA photolyase family
AC731_012740	COG1678	Uncharacterized ACR, COG1678
AC731_012745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AC731_012750	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AC731_012755	COG0540	Belongs to the ATCase OTCase family
AC731_012760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC731_012765	COG0762	integral membrane protein
AC731_012805	COG0437	4 iron, 4 sulfur cluster binding
AC731_012810	COG3383	formate dehydrogenase (NAD+) activity
AC731_012810	COG0243	molybdopterin cofactor binding
AC731_012845	COG0746	molybdenum cofactor guanylyltransferase activity
AC731_012860	COG2026	Addiction module toxin, RelE StbE family
AC731_012905	COG1131	(ABC) transporter
AC731_012910	COG4636	protein conserved in cyanobacteria
AC731_012915	COG1763	Mo-molybdopterin cofactor biosynthetic process
AC731_012920	COG3852	Histidine kinase
AC731_012945	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AC731_012950	COG5002	protein histidine kinase activity
AC731_012960	COG4654	Cytochrome c, class I
AC731_012965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC731_012965	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC731_012970	COG1492	cobalamin metabolic process
AC731_012975	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC731_012985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AC731_013000	COG0513	Belongs to the DEAD box helicase family
AC731_013005	COG0427	acetyl-CoA hydrolase
AC731_013020	COG0688	phosphatidylethanolamine metabolic process
AC731_013035	COG1797	cobyrinic acid a,c-diamide synthase activity
AC731_013040	COG1648	precorrin-2 dehydrogenase activity
AC731_013040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC731_013055	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AC731_013060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC731_013065	COG4206	TonB-dependent receptor
AC731_013075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AC731_013080	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AC731_013085	COG0406	alpha-ribazole phosphatase activity
AC731_013090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AC731_013090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AC731_013115	COG0438	transferase activity, transferring glycosyl groups
AC731_013120	COG0438	transferase activity, transferring glycosyl groups
AC731_013130	COG0859	PFAM glycosyl transferase family 9
AC731_013140	COG0438	transferase activity, transferring glycosyl groups
AC731_013145	COG0726	polysaccharide deacetylase
AC731_013150	COG1132	(ABC) transporter
AC731_013160	COG1682	transport, permease protein
AC731_013165	COG1134	teichoic acid transport
AC731_013195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AC731_013220	COG3668	Plasmid stabilization system
AC731_013235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AC731_013235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AC731_013260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AC731_013275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AC731_013280	COG0799	negative regulation of ribosome biogenesis
AC731_013285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AC731_013290	COG0424	maF-like protein
AC731_013295	COG1530	ribonuclease E activity
AC731_013320	COG1294	oxidase, subunit
AC731_013335	COG0410	ABC transporter
AC731_013350	COG0559	Belongs to the binding-protein-dependent transport system permease family
AC731_013360	COG0632	four-way junction helicase activity
AC731_013365	COG2255	four-way junction helicase activity
AC731_013380	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AC731_013390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AC731_013395	COG1560	Kdo2-lipid A biosynthetic process
AC731_013405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AC731_013420	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AC731_013425	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AC731_013430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC731_013435	COG3706	GGDEF domain
AC731_013435	COG0745	RESPONSE REGULATOR receiver
AC731_013440	COG0433	COG0433 Predicted ATPase
AC731_013450	COG0217	transcriptional regulatory protein
AC731_013460	COG0393	Putative heavy-metal-binding
AC731_013465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AC731_013510	COG2308	Evidence 4 Homologs of previously reported genes of
AC731_013540	COG2945	thiolester hydrolase activity
AC731_013540	COG0596	Alpha beta hydrolase
AC731_013545	COG0625	glutathione transferase activity
AC731_013550	COG1324	tolerance protein
AC731_013555	COG4232	protein-disulfide reductase activity
AC731_013570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AC731_013575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC731_013590	COG0375	protein maturation
AC731_013600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AC731_013605	COG0298	carbon dioxide binding
AC731_013610	COG0409	Hydrogenase expression formation protein
AC731_013615	COG0309	Hydrogenase expression formation protein (HypE)
AC731_013630	COG0765	amino acid transport
AC731_013635	COG1126	abc transporter atp-binding protein
AC731_013645	COG1335	isochorismatase
AC731_013650	COG0513	Belongs to the DEAD box helicase family
AC731_013655	COG0776	regulation of translation
AC731_013665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC731_013670	COG1194	a g-specific adenine glycosylase
AC731_013695	COG0559	Belongs to the binding-protein-dependent transport system permease family
AC731_013710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC731_013715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AC731_013725	COG1652	LysM domain
AC731_013745	COG3384	dioxygenase
AC731_013750	COG0583	DNA-binding transcription factor activity
AC731_013760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AC731_013780	COG0322	excinuclease ABC activity
AC731_013785	COG3300	MHYT domain
AC731_013785	COG5001	Diguanylate cyclase
AC731_013825	COG0693	protein deglycase activity
AC731_013830	COG3344	reverse transcriptase
AC731_013845	COG0210	DNA helicase
AC731_013865	COG2201	protein-glutamate methylesterase activity
AC731_013890	COG3284	Transcriptional regulator
AC731_013895	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_013905	COG1063	alcohol dehydrogenase
AC731_013920	COG1278	Cold shock
AC731_013935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AC731_013940	COG0321	lipoyl(octanoyl) transferase activity
AC731_013945	COG2921	Belongs to the UPF0250 family
AC731_013955	COG1686	Belongs to the peptidase S11 family
AC731_013965	COG0772	Belongs to the SEDS family
AC731_013970	COG0768	penicillin binding
AC731_013985	COG1077	Cell shape determining protein MreB Mrl
AC731_013990	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AC731_013995	COG0154	amidase activity
AC731_014005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AC731_014010	COG2391	methyltransferase activity
AC731_014015	COG0121	glutamine amidotransferase
AC731_014035	COG0745	RESPONSE REGULATOR receiver
AC731_014045	COG2226	methyltransferase
AC731_014060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AC731_014065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AC731_014070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AC731_014075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AC731_014080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC731_014085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AC731_014095	COG0356	it plays a direct role in the translocation of protons across the membrane
AC731_014115	COG1475	DNA binding
AC731_014120	COG1192	Involved in chromosome partitioning
AC731_014125	COG0357	Ribosomal RNA small subunit methyltransferase G
AC731_014130	COG0445	tRNA wobble uridine modification
AC731_014135	COG1024	Enoyl-CoA hydratase
AC731_014145	COG1024	Enoyl-CoA hydratase
AC731_014170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC731_014195	COG1132	(ABC) transporter
AC731_014210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AC731_014225	COG1253	flavin adenine dinucleotide binding
AC731_014230	COG3344	reverse transcriptase
AC731_014235	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AC731_014255	COG3179	chitinase
AC731_014265	COG2875	Belongs to the precorrin methyltransferase family
AC731_014280	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AC731_014315	COG0679	Auxin Efflux Carrier
AC731_014320	COG2186	Transcriptional regulator
AC731_014330	COG2084	Dehydrogenase
AC731_014340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC731_014345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_014360	COG2706	6-phosphogluconolactonase activity
AC731_014365	COG2721	sulfolactate sulfo-lyase activity
AC731_014375	COG1929	Belongs to the glycerate kinase type-1 family
AC731_014380	COG3835	regulator
AC731_014395	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AC731_014400	COG0840	transmembrane signaling receptor activity
AC731_014420	COG2974	May be involved in recombination
AC731_014430	COG1187	pseudouridine synthase activity
AC731_014445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC731_014455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AC731_014485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC731_014495	COG1858	cytochrome C peroxidase
AC731_014510	COG0348	domain, Protein
AC731_014520	COG3909	cytochrome
AC731_014530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC731_014535	COG4206	TonB-dependent receptor
AC731_014545	COG0551	DNA topoisomerase type I activity
AC731_014545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC731_014550	COG2922	Belongs to the Smg family
AC731_014555	COG0758	DNA mediated transformation
AC731_014560	COG1652	LysM domain
AC731_014565	COG0242	peptide deformylase activity
AC731_014570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AC731_014575	COG0501	Belongs to the peptidase M48B family
AC731_014580	COG3264	Mechanosensitive ion channel
AC731_014580	COG1196	nuclear chromosome segregation
AC731_014590	COG0583	DNA-binding transcription factor activity
AC731_014595	COG0477	Major facilitator Superfamily
AC731_014625	COG1451	nucleotide metabolic process
AC731_014630	COG3909	cytochrome
AC731_014635	COG3706	GGDEF domain
AC731_014645	COG1192	Involved in chromosome partitioning
AC731_014660	COG3781	membrane
AC731_014685	COG3706	GGDEF domain
AC731_014685	COG0745	RESPONSE REGULATOR receiver
AC731_014690	COG1802	Transcriptional regulator
AC731_014695	COG0730	response to heat
AC731_014700	COG0154	amidase activity
AC731_014715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC731_014720	COG1116	anion transmembrane transporter activity
AC731_014735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AC731_014740	COG0594	ribonuclease P activity
AC731_014745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AC731_014750	COG0706	membrane insertase activity
AC731_014755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AC731_014765	COG4106	trans-aconitate 2-methyltransferase activity
AC731_014780	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AC731_014785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AC731_014785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC731_014805	COG0569	domain protein
AC731_014815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AC731_014820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AC731_014830	COG1940	carbohydrate kinase activity
AC731_014835	COG0288	reversible hydration of carbon dioxide
AC731_014855	COG2223	nitrite transmembrane transporter activity
AC731_014865	COG2813	Specifically methylates the guanine in position
AC731_014865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC731_014870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC731_014880	COG2022	thiamine diphosphate biosynthetic process
AC731_014885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC731_014890	COG0616	signal peptide processing
AC731_014895	COG1881	PFAM PEBP family protein
AC731_014900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC731_014905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AC731_014910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AC731_014920	COG3266	domain, Protein
AC731_014920	COG0515	serine threonine protein kinase
AC731_014925	COG1561	YicC-like family, N-terminal region
AC731_014930	COG0194	GDP metabolic process
AC731_014935	COG1758	RNA polymerase activity
AC731_014940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC731_014945	COG3706	GGDEF domain
AC731_014955	COG1199	ATP-dependent helicase activity
AC731_014955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC731_014965	COG3850	Histidine kinase
AC731_014970	COG2197	response regulator
AC731_014975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC731_014975	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC731_014985	COG0243	molybdopterin cofactor binding
AC731_014990	COG0437	4 iron, 4 sulfur cluster binding
AC731_014995	COG0348	domain, Protein
AC731_015000	COG3043	anaerobic respiration
AC731_015005	COG3005	denitrification pathway
AC731_015010	COG4133	protoheme IX ABC transporter activity
AC731_015030	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC731_015040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC731_015050	COG4235	cytochrome complex assembly
AC731_015055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC731_015060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC731_015080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC731_015085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC731_015090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC731_015095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC731_015160	COG1476	TRANSCRIPTIONal
AC731_015190	COG1525	nuclease
AC731_015205	COG2135	peptidase activity
AC731_015210	COG0517	IMP dehydrogenase activity
AC731_015215	COG4974	Belongs to the 'phage' integrase family
AC731_015275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC731_015330	COG5002	protein histidine kinase activity
AC731_015340	COG0517	IMP dehydrogenase activity
AC731_015345	COG4974	Belongs to the 'phage' integrase family
AC731_015350	COG0488	(ABC) transporter
AC731_015355	COG3706	GGDEF domain
AC731_015365	COG2201	protein-glutamate methylesterase activity
AC731_015385	COG0419	ATPase involved in DNA repair
AC731_015390	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AC731_015395	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AC731_015400	COG0583	DNA-binding transcription factor activity
AC731_015420	COG2267	carboxylic ester hydrolase activity
AC731_015425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_015435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AC731_015445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_015450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_015455	COG1538	Outer membrane efflux protein
AC731_015460	COG0523	cobalamin synthesis protein
AC731_015470	COG2703	oxygen carrier activity
AC731_015480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AC731_015505	COG2095	MarC family integral membrane protein
AC731_015520	COG3447	MASE1 domain protein
AC731_015520	COG5002	protein histidine kinase activity
AC731_015520	COG5001	Diguanylate cyclase
AC731_015525	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AC731_015530	COG1739	Uncharacterized protein family UPF0029
AC731_015535	COG0783	Belongs to the Dps family
AC731_015540	COG3046	protein related to deoxyribodipyrimidine photolyase
AC731_015555	COG1074	ATP-dependent DNA helicase activity
AC731_015560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AC731_015580	COG3706	GGDEF domain
AC731_015605	COG2610	gluconate transmembrane transporter activity
AC731_015620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AC731_015625	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_015630	COG0827	DNA restriction-modification system
AC731_015630	COG0732	type I restriction modification DNA specificity domain
AC731_015635	COG3437	response regulator, receiver
AC731_015645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_015685	COG0410	ABC transporter
AC731_015705	COG0683	leucine binding
AC731_015715	COG1522	sequence-specific DNA binding
AC731_015725	COG0189	ligase activity
AC731_015740	COG1280	lysine exporter protein (LysE YggA)
AC731_015745	COG3135	benzoate transporter
AC731_015750	COG0697	spore germination
AC731_015760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AC731_015765	COG3383	formate dehydrogenase (NAD+) activity
AC731_015780	COG0583	DNA-binding transcription factor activity
AC731_015810	COG0154	amidase activity
AC731_015835	COG0346	lactoylglutathione lyase activity
AC731_015855	COG0488	(ABC) transporter
AC731_015870	COG0788	formyltetrahydrofolate deformylase activity
AC731_015875	COG0527	aspartate kinase activity
AC731_015880	COG0004	ammonium transporteR
AC731_015885	COG0347	Belongs to the P(II) protein family
AC731_015900	COG0606	chelatase, subunit chli
AC731_015915	COG0411	ABC transporter
AC731_015955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC731_015960	COG0583	DNA-binding transcription factor activity
AC731_015980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC731_016000	COG3876	Protein conserved in bacteria
AC731_016015	COG0668	transmembrane transport
AC731_016025	COG0180	Tryptophanyl-tRNA synthetase
AC731_016040	COG0583	DNA-binding transcription factor activity
AC731_016045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AC731_016050	COG4208	sulfate ABC transporter
AC731_016065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AC731_016070	COG0583	DNA-binding transcription factor activity
AC731_016075	COG3038	cytochrome b561
AC731_016085	COG2353	YceI-like domain
AC731_016090	COG1741	Belongs to the pirin family
AC731_016100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC731_016105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC731_016110	COG1414	Transcriptional regulator
AC731_016130	COG0730	response to heat
AC731_016140	COG1414	Transcriptional regulator
AC731_016190	COG2855	membrane
AC731_016195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AC731_016205	COG2022	thiamine diphosphate biosynthetic process
AC731_016210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC731_016220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC731_016225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_016230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AC731_016250	COG0583	DNA-binding transcription factor activity
AC731_016265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC731_016275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AC731_016280	COG0277	FAD linked oxidase domain protein
AC731_016300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC731_016360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC731_016365	COG0471	metal ion transport
AC731_016365	COG0490	domain, Protein
AC731_016375	COG0829	nickel cation binding
AC731_016380	COG0831	urea catabolic process
AC731_016385	COG0832	Belongs to the urease beta subunit family
AC731_016390	COG0804	urea catabolic process
AC731_016395	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AC731_016400	COG0830	nickel cation binding
AC731_016405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AC731_016415	COG0840	transmembrane signaling receptor activity
AC731_016415	COG0840	transmembrane signaling receptor activity
AC731_016425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AC731_016435	COG1012	belongs to the aldehyde dehydrogenase family
AC731_016485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AC731_016490	COG2233	PERMEase
AC731_016505	COG4575	ribosome binding
AC731_016510	COG2226	methyltransferase
AC731_016515	COG0708	Exodeoxyribonuclease III
AC731_016520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AC731_016540	COG0251	oxidation-reduction process
AC731_016545	COG1238	metal cluster binding
AC731_016560	COG0037	tRNA processing
AC731_016565	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_016585	COG0617	tRNA 3'-terminal CCA addition
AC731_016605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AC731_016610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AC731_016615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AC731_016625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AC731_016630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AC731_016635	COG1137	ATPase activity
AC731_016640	COG2137	regulation of response to DNA damage stimulus
AC731_016645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AC731_016650	COG1546	Belongs to the CinA family
AC731_016655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AC731_016680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC731_016685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC731_016690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC731_016695	COG0018	arginyl-trna synthetase
AC731_016705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC731_016725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AC731_016740	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC731_016760	COG0288	reversible hydration of carbon dioxide
AC731_016765	COG0183	Belongs to the thiolase family
AC731_016770	COG1960	acyl-CoA dehydrogenase activity
AC731_016775	COG2807	transmembrane transport
AC731_016790	COG2159	amidohydrolase
AC731_016820	COG0667	Aldo Keto reductase
AC731_016830	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_016840	COG1053	succinate dehydrogenase
AC731_016845	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_016870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_016875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AC731_016880	COG0583	DNA-binding transcription factor activity
AC731_016925	COG0589	response to stress
AC731_016930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC731_016935	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AC731_016940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AC731_016945	COG1414	Transcriptional regulator
AC731_016965	COG1414	Transcriptional regulator
AC731_016985	COG0673	inositol 2-dehydrogenase activity
AC731_016990	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_017005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC731_017035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AC731_017040	COG0583	DNA-binding transcription factor activity
AC731_017045	COG1760	l-serine dehydratase
AC731_017050	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AC731_017070	COG1607	acyl-coa hydrolase
AC731_017095	COG1960	acyl-CoA dehydrogenase activity
AC731_017115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC731_017120	COG1024	Enoyl-CoA hydratase
AC731_017130	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_017145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC731_017150	COG1132	(ABC) transporter
AC731_017160	COG0644	oxidoreductase
AC731_017195	COG1012	belongs to the aldehyde dehydrogenase family
AC731_017205	COG1115	amino acid carrier protein
AC731_017210	COG1660	Displays ATPase and GTPase activities
AC731_017225	COG0412	Dienelactone hydrolase
AC731_017230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AC731_017235	COG1671	Belongs to the UPF0178 family
AC731_017250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AC731_017255	COG0602	queuosine metabolic process
AC731_017270	COG0823	Involved in the tonB-independent uptake of proteins
AC731_017280	COG0848	biopolymer transport protein
AC731_017290	COG0824	Thioesterase
AC731_017300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AC731_017305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AC731_017320	COG0330	HflC and HflK could
AC731_017345	COG2895	sulfate adenylyltransferase (ATP) activity
AC731_017350	COG0175	sulfate reduction
AC731_017355	COG0175	sulfate reduction
AC731_017370	COG0583	DNA-binding transcription factor activity
AC731_017375	COG0252	asparaginase activity
AC731_017380	COG0475	glutathione-regulated potassium exporter activity
AC731_017380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC731_017385	COG5265	(ABC) transporter
AC731_017405	COG1024	Enoyl-CoA hydratase
AC731_017405	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC731_017410	COG1607	acyl-coa hydrolase
AC731_017415	COG2067	long-chain fatty acid transport protein
AC731_017420	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC731_017420	COG1024	Enoyl-CoA hydratase
AC731_017425	COG0183	Belongs to the thiolase family
AC731_017435	COG1805	sodium ion transport
AC731_017480	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AC731_017490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AC731_017495	COG3161	chorismate lyase activity
AC731_017500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC731_017505	COG0284	orotidine-5'-phosphate decarboxylase activity
AC731_017510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AC731_017530	COG0019	diaminopimelate decarboxylase activity
AC731_017535	COG1965	Belongs to the frataxin family
AC731_017570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AC731_017575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AC731_017580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AC731_017585	COG0069	glutamate synthase activity
AC731_017585	COG0070	glutamate synthase
AC731_017585	COG0067	glutamate synthase
AC731_017595	COG0747	negative chemotaxis
AC731_017600	COG2203	Gaf domain
AC731_017600	COG3706	GGDEF domain
AC731_017600	COG5001	Diguanylate cyclase
AC731_017600	COG4251	negative regulation of phosphorylation
AC731_017615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC731_017625	COG0405	Gamma-glutamyltransferase
AC731_017630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AC731_017640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC731_017650	COG0348	domain, Protein
AC731_017665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC731_017670	COG4974	Belongs to the 'phage' integrase family
AC731_017680	COG5002	protein histidine kinase activity
AC731_017705	COG2132	Multicopper oxidase
AC731_017730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_017760	COG0840	transmembrane signaling receptor activity
AC731_017765	COG0840	transmembrane signaling receptor activity
AC731_017785	COG1280	lysine exporter protein (LysE YggA)
AC731_017815	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC731_017830	COG1022	Amp-dependent synthetase and ligase
AC731_017835	COG1024	Enoyl-CoA hydratase
AC731_017840	COG1960	acyl-CoA dehydrogenase activity
AC731_017855	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_017860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC731_017880	COG0628	permease
AC731_017890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC731_017895	COG1702	phosphate starvation-inducible protein PhoH
AC731_017900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AC731_017905	COG4535	Mg2 and Co2 transporter CorC
AC731_017910	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AC731_017915	COG0752	glycyl-tRNA synthetase alpha subunit
AC731_017920	COG0751	glycine-tRNA ligase activity
AC731_017925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AC731_017930	COG0204	Acyl-transferase
AC731_017935	COG2154	pterin-4-alpha-carbinolamine dehydratase
AC731_017945	COG1024	Enoyl-CoA hydratase
AC731_017950	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AC731_018010	COG1127	ABC transporter
AC731_018015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC731_018020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC731_018040	COG1131	(ABC) transporter
AC731_018045	COG0842	Transport permease protein
AC731_018055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AC731_018060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC731_018065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AC731_018070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AC731_018075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC731_018080	COG0131	Imidazoleglycerol-phosphate dehydratase
AC731_018085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AC731_018090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AC731_018095	COG0107	imidazoleglycerol-phosphate synthase activity
AC731_018100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AC731_018105	COG0140	phosphoribosyl-ATP diphosphatase activity
AC731_018115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC731_018120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC731_018130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC731_018135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AC731_018150	COG0045	succinate-CoA ligase (ADP-forming) activity
AC731_018155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AC731_018180	COG0546	phosphoglycolate phosphatase activity
AC731_018195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC731_018200	COG0134	indole-3-glycerol-phosphate synthase activity
AC731_018210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC731_018220	COG1522	sequence-specific DNA binding
AC731_018225	COG0733	neurotransmitter:sodium symporter activity
AC731_018290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC731_018310	COG0300	oxidoreductase activity
AC731_018325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AC731_018330	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AC731_018365	COG0109	protoheme IX farnesyltransferase activity
AC731_018370	COG1999	signal sequence binding
AC731_018375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC731_018390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AC731_018405	COG0537	adenosine 5'-monophosphoramidase activity
AC731_018425	COG2264	protein methyltransferase activity
AC731_018430	COG0439	Biotin carboxylase
AC731_018435	COG0511	ligase activity, forming carbon-carbon bonds
AC731_018440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC731_018450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC731_018460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AC731_018465	COG0792	nuclease activity
AC731_018475	COG0418	dihydroorotase activity
AC731_018490	COG2001	Belongs to the MraZ family
AC731_018495	COG0275	rRNA processing
AC731_018500	COG3116	cell division
AC731_018510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC731_018515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC731_018520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC731_018525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AC731_018530	COG0772	Belongs to the SEDS family
AC731_018535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC731_018540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC731_018545	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC731_018550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AC731_018560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AC731_018565	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AC731_018580	COG0653	protein targeting
AC731_018620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AC731_018625	COG2967	ApaG domain
AC731_018640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC731_018645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC731_018650	COG1862	Preprotein translocase
AC731_018655	COG0343	queuine tRNA-ribosyltransferase activity
AC731_018660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AC731_018705	COG0583	DNA-binding transcription factor activity
AC731_018715	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AC731_018735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC731_018755	COG0583	DNA-binding transcription factor activity
AC731_018765	COG0670	Belongs to the BI1 family
AC731_018770	COG0825	malonyl-CoA metabolic process
AC731_018775	COG0037	tRNA processing
AC731_018805	COG0105	UTP biosynthetic process
AC731_018810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AC731_018825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AC731_018830	COG0124	histidyl-tRNA synthetase
AC731_018840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC731_018845	COG1160	GTP binding
AC731_018850	COG1923	regulation of RNA biosynthetic process
AC731_018855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AC731_018860	COG0330	HflC and HflK could
AC731_018865	COG0330	HflC and HflK could
AC731_018875	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AC731_018880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AC731_018895	COG0557	exoribonuclease II activity
AC731_018900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC731_018905	COG0778	Nitroreductase
AC731_018910	COG5001	Diguanylate cyclase
AC731_018915	COG0471	metal ion transport
AC731_018915	COG0490	domain, Protein
AC731_018930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC731_018945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC731_018950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AC731_018955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AC731_018960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AC731_018965	COG0723	plastoquinol--plastocyanin reductase activity
AC731_018970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AC731_018975	COG2857	Cytochrome c1
AC731_018980	COG0625	glutathione transferase activity
AC731_018985	COG2969	positive regulation of protein catabolic process
AC731_018990	COG2703	oxygen carrier activity
AC731_018995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC731_019000	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AC731_019010	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AC731_019020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC731_019030	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC731_019030	COG0022	dehydrogenase e1 component
AC731_019050	COG2226	methyltransferase
AC731_019085	COG2409	Drug exporters of the RND superfamily
AC731_019090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AC731_019095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AC731_019100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AC731_019105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AC731_019115	COG0631	protein serine/threonine phosphatase activity
AC731_019125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC731_019130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AC731_019145	COG0513	Belongs to the DEAD box helicase family
AC731_019150	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AC731_019160	COG1653	transport
AC731_019165	COG0142	geranyltranstransferase activity
AC731_019175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AC731_019180	COG2096	Adenosyltransferase
AC731_019185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AC731_019200	COG0429	hydrolase of the alpha beta-hydrolase fold
AC731_019230	COG0482	sulfurtransferase activity
AC731_019255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AC731_019260	COG3164	Protein of unknown function
AC731_019265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC731_019270	COG0312	modulator of DNA gyrase
AC731_019285	COG2204	response regulator
AC731_019295	COG2205	protein histidine kinase activity
AC731_019305	COG0741	lytic transglycosylase activity
AC731_019310	COG0442	prolyl-tRNA aminoacylation
AC731_019315	COG0494	nUDIX hydrolase
AC731_019325	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AC731_019330	COG1765	OsmC-like protein
AC731_019335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AC731_019340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AC731_019345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AC731_019350	COG0316	Belongs to the HesB IscA family
AC731_019355	COG0739	heme binding
AC731_019360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC731_019365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis