locus-tag	class	description
Tmz1t_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tmz1t_0004	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tmz1t_0005	COG0732	type I restriction modification DNA specificity domain
Tmz1t_0006	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tmz1t_0010	COG4584	PFAM Integrase catalytic
Tmz1t_0027	COG5433	transposase activity
Tmz1t_0040	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tmz1t_0041	COG3657	addiction module killer protein
Tmz1t_0044	COG2161	toxin-antitoxin pair type II binding
Tmz1t_0048	COG4942	peptidase
Tmz1t_0053	COG1136	(ABC) transporter
Tmz1t_0053	COG0577	efflux transmembrane transporter activity
Tmz1t_0058	COG0443	Heat shock 70 kDa protein
Tmz1t_0062	COG1451	nucleotide metabolic process
Tmz1t_0063	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Tmz1t_0070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tmz1t_0074	COG0142	geranyltranstransferase activity
Tmz1t_0075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tmz1t_0078	COG1132	(ABC) transporter
Tmz1t_0085	COG1404	Belongs to the peptidase S8 family
Tmz1t_0087	COG1024	Enoyl-CoA hydratase
Tmz1t_0088	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Tmz1t_0091	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Tmz1t_0092	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tmz1t_0093	COG0501	Belongs to the peptidase M48B family
Tmz1t_0094	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tmz1t_0095	COG0242	peptide deformylase activity
Tmz1t_0097	COG0758	DNA mediated transformation
Tmz1t_0098	COG2922	Belongs to the Smg family
Tmz1t_0100	COG1522	sequence-specific DNA binding
Tmz1t_0102	COG0783	Belongs to the Dps family
Tmz1t_0104	COG4206	TonB-dependent receptor
Tmz1t_0105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tmz1t_0106	COG0840	transmembrane signaling receptor activity
Tmz1t_0107	COG3909	cytochrome
Tmz1t_0110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tmz1t_0121	COG0583	DNA-binding transcription factor activity
Tmz1t_0122	COG0477	Major facilitator Superfamily
Tmz1t_0123	COG2009	succinate dehydrogenase
Tmz1t_0125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tmz1t_0132	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tmz1t_0135	COG1187	pseudouridine synthase activity
Tmz1t_0137	COG2974	May be involved in recombination
Tmz1t_0141	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
Tmz1t_0143	COG1473	amidohydrolase
Tmz1t_0146	COG0583	DNA-binding transcription factor activity
Tmz1t_0147	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Tmz1t_0149	COG0114	fumarate hydratase activity
Tmz1t_0150	COG3835	regulator
Tmz1t_0151	COG1929	Belongs to the glycerate kinase type-1 family
Tmz1t_0152	COG0679	Auxin Efflux Carrier
Tmz1t_0157	COG1607	acyl-coa hydrolase
Tmz1t_0159	COG0642	Histidine kinase
Tmz1t_0163	COG1902	pentaerythritol trinitrate reductase activity
Tmz1t_0165	COG0390	transport system, permease component
Tmz1t_0166	COG1116	anion transmembrane transporter activity
Tmz1t_0168	COG3264	Mechanosensitive ion channel
Tmz1t_0168	COG1196	nuclear chromosome segregation
Tmz1t_0169	COG0477	Major facilitator Superfamily
Tmz1t_0170	COG2816	NAD+ diphosphatase activity
Tmz1t_0177	COG1575	Belongs to the MenA family. Type 1 subfamily
Tmz1t_0179	COG3851	Histidine kinase
Tmz1t_0180	COG2197	response regulator
Tmz1t_0183	COG1192	Involved in chromosome partitioning
Tmz1t_0188	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tmz1t_0190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tmz1t_0190	COG0574	Belongs to the PEP-utilizing enzyme family
Tmz1t_0192	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmz1t_0194	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tmz1t_0194	COG1017	nitric oxide dioxygenase activity
Tmz1t_0196	COG3327	negative regulation of DNA-templated transcription, initiation
Tmz1t_0199	COG0243	molybdopterin cofactor binding
Tmz1t_0200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tmz1t_0202	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tmz1t_0204	COG0445	tRNA wobble uridine modification
Tmz1t_0205	COG0357	Ribosomal RNA small subunit methyltransferase G
Tmz1t_0206	COG1192	Involved in chromosome partitioning
Tmz1t_0207	COG1475	DNA binding
Tmz1t_0209	COG0356	it plays a direct role in the translocation of protons across the membrane
Tmz1t_0211	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tmz1t_0212	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tmz1t_0213	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tmz1t_0214	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tmz1t_0215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tmz1t_0216	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tmz1t_0219	COG2226	methyltransferase
Tmz1t_0227	COG0745	RESPONSE REGULATOR receiver
Tmz1t_0231	COG0121	glutamine amidotransferase
Tmz1t_0232	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tmz1t_0234	COG0154	amidase activity
Tmz1t_0235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tmz1t_0236	COG1077	Cell shape determining protein MreB Mrl
Tmz1t_0239	COG0768	penicillin binding
Tmz1t_0240	COG0772	Belongs to the SEDS family
Tmz1t_0242	COG1686	Belongs to the peptidase S11 family
Tmz1t_0243	COG2921	Belongs to the UPF0250 family
Tmz1t_0244	COG0321	lipoyl(octanoyl) transferase activity
Tmz1t_0245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tmz1t_0248	COG2703	oxygen carrier activity
Tmz1t_0249	COG0210	DNA helicase
Tmz1t_0262	COG4974	Belongs to the 'phage' integrase family
Tmz1t_0263	COG0517	IMP dehydrogenase activity
Tmz1t_0265	COG0861	Integral membrane protein TerC family
Tmz1t_0266	COG1253	flavin adenine dinucleotide binding
Tmz1t_0267	COG0501	Belongs to the peptidase M48B family
Tmz1t_0268	COG0628	permease
Tmz1t_0270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tmz1t_0273	COG2433	Pfam Transposase IS66
Tmz1t_0276	COG2963	transposase activity
Tmz1t_0278	COG4372	Transposase
Tmz1t_0281	COG2433	Pfam Transposase IS66
Tmz1t_0284	COG2135	peptidase activity
Tmz1t_0288	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tmz1t_0317	COG4584	PFAM Integrase catalytic
Tmz1t_0321	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmz1t_0323	COG1538	Outer membrane efflux protein
Tmz1t_0325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tmz1t_0331	COG0583	DNA-binding transcription factor activity
Tmz1t_0336	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tmz1t_0338	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tmz1t_0342	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tmz1t_0356	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tmz1t_0359	COG5002	protein histidine kinase activity
Tmz1t_0361	COG0437	4 iron, 4 sulfur cluster binding
Tmz1t_0362	COG0243	molybdopterin cofactor binding
Tmz1t_0370	COG4974	Belongs to the 'phage' integrase family
Tmz1t_0371	COG0582	viral genome integration into host DNA
Tmz1t_0372	COG4974	Belongs to the 'phage' integrase family
Tmz1t_0373	COG4974	Belongs to the 'phage' integrase family
Tmz1t_0378	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tmz1t_0379	COG0573	inorganic phosphate transmembrane transporter activity
Tmz1t_0380	COG0573	inorganic phosphate transmembrane transporter activity
Tmz1t_0381	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tmz1t_0382	COG2204	response regulator
Tmz1t_0383	COG3852	Histidine kinase
Tmz1t_0387	COG0243	molybdopterin cofactor binding
Tmz1t_0396	COG3530	Putative quorum-sensing-regulated virulence factor
Tmz1t_0397	COG0420	3'-5' exonuclease activity
Tmz1t_0403	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tmz1t_0405	COG0410	ABC transporter
Tmz1t_0406	COG1022	Amp-dependent synthetase and ligase
Tmz1t_0407	COG1024	Enoyl-CoA hydratase
Tmz1t_0408	COG1960	acyl-CoA dehydrogenase activity
Tmz1t_0409	COG0183	Belongs to the thiolase family
Tmz1t_0412	COG1959	2 iron, 2 sulfur cluster binding
Tmz1t_0414	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Tmz1t_0417	COG2095	MarC family integral membrane protein
Tmz1t_0418	COG0583	DNA-binding transcription factor activity
Tmz1t_0419	COG1960	acyl-CoA dehydrogenase activity
Tmz1t_0420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tmz1t_0424	COG3842	ATPase activity
Tmz1t_0426	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tmz1t_0427	COG1177	transmembrane transport
Tmz1t_0430	COG0579	oxidoreductase
Tmz1t_0439	COG0513	Belongs to the DEAD box helicase family
Tmz1t_0440	COG0776	regulation of translation
Tmz1t_0442	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tmz1t_0443	COG1194	a g-specific adenine glycosylase
Tmz1t_0449	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tmz1t_0451	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tmz1t_0452	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tmz1t_0453	COG1652	LysM domain
Tmz1t_0456	COG2860	membrane
Tmz1t_0457	COG0004	ammonium transporteR
Tmz1t_0458	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tmz1t_0459	COG0569	domain protein
Tmz1t_0466	COG2233	PERMEase
Tmz1t_0467	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tmz1t_0468	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tmz1t_0469	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tmz1t_0472	COG0488	(ABC) transporter
Tmz1t_0474	COG2197	response regulator
Tmz1t_0476	COG4585	Histidine kinase
Tmz1t_0486	COG5433	transposase activity
Tmz1t_0489	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tmz1t_0491	COG2226	methyltransferase
Tmz1t_0497	COG2267	carboxylic ester hydrolase activity
Tmz1t_0498	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tmz1t_0499	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Tmz1t_0504	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmz1t_0505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tmz1t_0506	COG1538	Outer membrane efflux protein
Tmz1t_0507	COG0523	cobalamin synthesis protein
Tmz1t_0509	COG2703	oxygen carrier activity
Tmz1t_0518	COG1739	Uncharacterized protein family UPF0029
Tmz1t_0519	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Tmz1t_0520	COG1984	allophanate hydrolase subunit 2
Tmz1t_0521	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Tmz1t_0526	COG0583	DNA-binding transcription factor activity
Tmz1t_0527	COG1760	l-serine dehydratase
Tmz1t_0528	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Tmz1t_0531	COG3046	protein related to deoxyribodipyrimidine photolyase
Tmz1t_0532	COG5001	Diguanylate cyclase
Tmz1t_0533	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tmz1t_0541	COG1414	Transcriptional regulator
Tmz1t_0542	COG0277	FAD linked oxidase domain protein
Tmz1t_0544	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Tmz1t_0545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tmz1t_0552	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tmz1t_0554	COG0732	type I restriction modification DNA specificity domain
Tmz1t_0554	COG0827	DNA restriction-modification system
Tmz1t_0556	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tmz1t_0557	COG0642	Histidine kinase
Tmz1t_0559	COG3174	membrane
Tmz1t_0565	COG0410	ABC transporter
Tmz1t_0569	COG0683	leucine binding
Tmz1t_0571	COG1522	sequence-specific DNA binding
Tmz1t_0572	COG3158	transport of potassium into the cell
Tmz1t_0574	COG0189	ligase activity
Tmz1t_0578	COG0697	spore germination
Tmz1t_0581	COG0488	(ABC) transporter
Tmz1t_0584	COG0788	formyltetrahydrofolate deformylase activity
Tmz1t_0586	COG2423	ornithine cyclodeaminase activity
Tmz1t_0587	COG0527	aspartate kinase activity
Tmz1t_0588	COG2050	protein possibly involved in aromatic compounds catabolism
Tmz1t_0593	COG0004	ammonium transporteR
Tmz1t_0594	COG0347	Belongs to the P(II) protein family
Tmz1t_0598	COG2814	Major facilitator Superfamily
Tmz1t_0600	COG0410	ABC transporter
Tmz1t_0601	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tmz1t_0603	COG0683	leucine binding
Tmz1t_0607	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Tmz1t_0608	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Tmz1t_0609	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tmz1t_0610	COG0583	DNA-binding transcription factor activity
Tmz1t_0613	COG3781	membrane
Tmz1t_0614	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tmz1t_0615	COG0659	secondary active sulfate transmembrane transporter activity
Tmz1t_0616	COG3876	Protein conserved in bacteria
Tmz1t_0620	COG0180	Tryptophanyl-tRNA synthetase
Tmz1t_0621	COG0583	DNA-binding transcription factor activity
Tmz1t_0622	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Tmz1t_0623	COG4208	sulfate ABC transporter
Tmz1t_0627	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tmz1t_0628	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Tmz1t_0629	COG4221	oxidoreductase activity
Tmz1t_0631	COG3273	potassium ion transport
Tmz1t_0631	COG0471	metal ion transport
Tmz1t_0633	COG2319	Wd-40 repeat
Tmz1t_0633	COG4249	Peptidase C14 caspase catalytic subunit p20
Tmz1t_0634	COG0583	DNA-binding transcription factor activity
Tmz1t_0637	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tmz1t_0642	COG1305	Transglutaminase-like
Tmz1t_0643	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tmz1t_0644	COG1024	Enoyl-CoA hydratase
Tmz1t_0646	COG2814	Major facilitator Superfamily
Tmz1t_0647	COG2814	Major facilitator Superfamily
Tmz1t_0650	COG1607	acyl-coa hydrolase
Tmz1t_0659	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
Tmz1t_0664	COG4263	nitrous-oxide reductase activity
Tmz1t_0666	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Tmz1t_0671	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tmz1t_0672	COG2233	PERMEase
Tmz1t_0675	COG4575	ribosome binding
Tmz1t_0676	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tmz1t_0679	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tmz1t_0681	COG1136	(ABC) transporter
Tmz1t_0681	COG0577	efflux transmembrane transporter activity
Tmz1t_0686	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tmz1t_0688	COG0243	molybdopterin cofactor binding
Tmz1t_0691	COG0251	oxidation-reduction process
Tmz1t_0692	COG1238	metal cluster binding
Tmz1t_0695	COG0037	tRNA processing
Tmz1t_0699	COG0617	tRNA 3'-terminal CCA addition
Tmz1t_0702	COG0741	lytic transglycosylase activity
Tmz1t_0703	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Tmz1t_0704	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tmz1t_0705	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Tmz1t_0707	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Tmz1t_0708	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tmz1t_0710	COG2137	regulation of response to DNA damage stimulus
Tmz1t_0711	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tmz1t_0712	COG1546	Belongs to the CinA family
Tmz1t_0713	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tmz1t_0714	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Tmz1t_0719	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tmz1t_0720	COG0018	arginyl-trna synthetase
Tmz1t_0722	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tmz1t_0726	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tmz1t_0728	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tmz1t_0731	COG0288	reversible hydration of carbon dioxide
Tmz1t_0732	COG0183	Belongs to the thiolase family
Tmz1t_0733	COG1960	acyl-CoA dehydrogenase activity
Tmz1t_0738	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tmz1t_0738	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tmz1t_0748	COG1960	acyl-CoA dehydrogenase activity
Tmz1t_0749	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tmz1t_0752	COG0318	PFAM AMP-dependent synthetase and ligase
Tmz1t_0757	COG1132	(ABC) transporter
Tmz1t_0766	COG1012	belongs to the aldehyde dehydrogenase family
Tmz1t_0770	COG1115	amino acid carrier protein
Tmz1t_0771	COG1660	Displays ATPase and GTPase activities
Tmz1t_0774	COG0412	Dienelactone hydrolase
Tmz1t_0775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tmz1t_0778	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Tmz1t_0779	COG0602	queuosine metabolic process
Tmz1t_0781	COG2885	chlorophyll binding
Tmz1t_0782	COG0823	Involved in the tonB-independent uptake of proteins
Tmz1t_0786	COG0824	Thioesterase
Tmz1t_0788	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tmz1t_0789	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tmz1t_0791	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Tmz1t_0793	COG2895	sulfate adenylyltransferase (ATP) activity
Tmz1t_0794	COG0175	sulfate reduction
Tmz1t_0796	COG0175	sulfate reduction
Tmz1t_0799	COG0730	response to heat
Tmz1t_0800	COG0583	DNA-binding transcription factor activity
Tmz1t_0801	COG0252	asparaginase activity
Tmz1t_0803	COG5265	(ABC) transporter
Tmz1t_0807	COG1024	Enoyl-CoA hydratase
Tmz1t_0807	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tmz1t_0809	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tmz1t_0809	COG1024	Enoyl-CoA hydratase
Tmz1t_0810	COG0183	Belongs to the thiolase family
Tmz1t_0812	COG1805	sodium ion transport
Tmz1t_0820	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Tmz1t_0822	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tmz1t_0823	COG3161	chorismate lyase activity
Tmz1t_0824	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Tmz1t_0825	COG0284	orotidine-5'-phosphate decarboxylase activity
Tmz1t_0826	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tmz1t_0832	COG1965	Belongs to the frataxin family
Tmz1t_0839	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tmz1t_0840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tmz1t_0841	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tmz1t_0842	COG0069	glutamate synthase activity
Tmz1t_0842	COG0067	glutamate synthase
Tmz1t_0842	COG0070	glutamate synthase
Tmz1t_0845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tmz1t_0855	COG2814	Major facilitator Superfamily
Tmz1t_0856	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tmz1t_0865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmz1t_0866	COG1702	phosphate starvation-inducible protein PhoH
Tmz1t_0867	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tmz1t_0868	COG4535	Mg2 and Co2 transporter CorC
Tmz1t_0869	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Tmz1t_0870	COG0752	glycyl-tRNA synthetase alpha subunit
Tmz1t_0871	COG0751	glycine-tRNA ligase activity
Tmz1t_0872	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Tmz1t_0873	COG0204	Acyl-transferase
Tmz1t_0874	COG2154	pterin-4-alpha-carbinolamine dehydratase
Tmz1t_0877	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Tmz1t_0885	COG1459	type II secretion system
Tmz1t_0887	COG1450	Type ii and iii secretion system protein
Tmz1t_0888	COG1127	ABC transporter
Tmz1t_0889	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tmz1t_0890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Tmz1t_0894	COG1131	(ABC) transporter
Tmz1t_0895	COG0842	Transport permease protein
Tmz1t_0896	COG0271	Belongs to the BolA IbaG family
Tmz1t_0897	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tmz1t_0898	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tmz1t_0899	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tmz1t_0900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tmz1t_0902	COG3842	ATPase activity
Tmz1t_0903	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tmz1t_0904	COG1177	transmembrane transport
Tmz1t_0905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tmz1t_0906	COG0131	Imidazoleglycerol-phosphate dehydratase
Tmz1t_0907	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tmz1t_0908	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tmz1t_0909	COG0107	imidazoleglycerol-phosphate synthase activity
Tmz1t_0910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tmz1t_0911	COG0140	phosphoribosyl-ATP diphosphatase activity
Tmz1t_0913	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tmz1t_0914	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tmz1t_0916	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tmz1t_0917	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tmz1t_0919	COG0045	succinate-CoA ligase (ADP-forming) activity
Tmz1t_0920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tmz1t_0925	COG0546	phosphoglycolate phosphatase activity
Tmz1t_0935	COG4195	phage-related replication protein
Tmz1t_0939	COG0084	hydrolase, TatD family'
Tmz1t_0946	COG2003	Belongs to the UPF0758 family
Tmz1t_0958	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tmz1t_0961	COG0326	Molecular chaperone. Has ATPase activity
Tmz1t_0981	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tmz1t_0982	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tmz1t_0983	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tmz1t_0983	COG0519	Catalyzes the synthesis of GMP from XMP
Tmz1t_0985	COG3135	benzoate transporter
Tmz1t_0990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tmz1t_0999	COG1192	Involved in chromosome partitioning
Tmz1t_1002	COG0583	DNA-binding transcription factor activity
Tmz1t_1009	COG1611	Belongs to the LOG family
Tmz1t_1017	COG0842	Transport permease protein
Tmz1t_1018	COG0842	Transport permease protein
Tmz1t_1019	COG1131	(ABC) transporter
Tmz1t_1020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmz1t_1022	COG1309	transcriptional regulator
Tmz1t_1025	COG1028	Short-chain dehydrogenase reductase Sdr
Tmz1t_1027	COG0583	DNA-binding transcription factor activity
Tmz1t_1029	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tmz1t_1030	COG0134	indole-3-glycerol-phosphate synthase activity
Tmz1t_1032	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tmz1t_1034	COG1522	sequence-specific DNA binding
Tmz1t_1035	COG0733	neurotransmitter:sodium symporter activity
Tmz1t_1038	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Tmz1t_1038	COG1565	acr, cog1565
Tmz1t_1039	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tmz1t_1040	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Tmz1t_1046	COG0109	protoheme IX farnesyltransferase activity
Tmz1t_1047	COG0514	ATP-dependent DNA helicase (RecQ)
Tmz1t_1052	COG1469	GTP cyclohydrolase I activity
Tmz1t_1055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tmz1t_1059	COG0300	oxidoreductase activity
Tmz1t_1061	COG1999	signal sequence binding
Tmz1t_1077	COG2255	four-way junction helicase activity
Tmz1t_1087	COG3023	N-Acetylmuramoyl-L-alanine amidase
Tmz1t_1092	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Tmz1t_1093	COG0280	phosphate acetyltransferase
Tmz1t_1093	COG0281	malic enzyme
Tmz1t_1095	COG1686	Belongs to the peptidase S11 family
Tmz1t_1100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tmz1t_1100	COG2111	Na H antiporter
Tmz1t_1101	COG1006	Multisubunit Na H antiporter MnhC subunit
Tmz1t_1102	COG0651	ATP synthesis coupled electron transport
Tmz1t_1104	COG2212	antiporter activity
Tmz1t_1105	COG1320	monovalent cation:proton antiporter activity
Tmz1t_1106	COG1187	pseudouridine synthase activity
Tmz1t_1107	COG1320	monovalent cation:proton antiporter activity
Tmz1t_1112	COG2111	Na H antiporter
Tmz1t_1112	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tmz1t_1115	COG3206	protein involved in exopolysaccharide biosynthesis
Tmz1t_1115	COG0489	protein tyrosine kinase activity
Tmz1t_1116	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Tmz1t_1117	COG2755	lipolytic protein G-D-S-L family
Tmz1t_1117	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Tmz1t_1122	COG0438	transferase activity, transferring glycosyl groups
Tmz1t_1125	COG0438	transferase activity, transferring glycosyl groups
Tmz1t_1126	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tmz1t_1130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tmz1t_1134	COG0737	Belongs to the 5'-nucleotidase family
Tmz1t_1136	COG2916	Histone family protein nucleoid-structuring protein H-NS
Tmz1t_1140	COG0778	Nitroreductase
Tmz1t_1141	COG3707	response regulator
Tmz1t_1142	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tmz1t_1143	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tmz1t_1143	COG2146	nitrite reductase [NAD(P)H] activity
Tmz1t_1144	COG2814	Major facilitator Superfamily
Tmz1t_1145	COG2223	nitrite transmembrane transporter activity
Tmz1t_1146	COG0515	serine threonine protein kinase
Tmz1t_1147	COG0243	molybdopterin cofactor binding
Tmz1t_1148	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tmz1t_1150	COG0842	Transport permease protein
Tmz1t_1151	COG1129	ABC transporter
Tmz1t_1151	COG0842	Transport permease protein
Tmz1t_1152	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmz1t_1154	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tmz1t_1155	COG1127	ABC transporter
Tmz1t_1158	COG2326	polyphosphate kinase activity
Tmz1t_1162	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmz1t_1164	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tmz1t_1165	COG0071	Belongs to the small heat shock protein (HSP20) family
Tmz1t_1170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tmz1t_1176	COG4536	flavin adenine dinucleotide binding
Tmz1t_1178	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tmz1t_1184	COG2070	2-Nitropropane dioxygenase
Tmz1t_1185	COG0604	alcohol dehydrogenase
Tmz1t_1187	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmz1t_1189	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tmz1t_1191	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tmz1t_1192	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tmz1t_1193	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tmz1t_1195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tmz1t_1199	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tmz1t_1200	COG1466	dna polymerase III delta subunit
Tmz1t_1202	COG0495	leucyl-tRNA aminoacylation
Tmz1t_1204	COG0210	DNA helicase
Tmz1t_1212	COG0482	sulfurtransferase activity
Tmz1t_1217	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Tmz1t_1219	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tmz1t_1220	COG0312	modulator of DNA gyrase
Tmz1t_1222	COG2204	response regulator
Tmz1t_1224	COG2205	protein histidine kinase activity
Tmz1t_1226	COG0741	lytic transglycosylase activity
Tmz1t_1227	COG0442	prolyl-tRNA aminoacylation
Tmz1t_1228	COG0494	nUDIX hydrolase
Tmz1t_1230	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Tmz1t_1231	COG1765	OsmC-like protein
Tmz1t_1232	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tmz1t_1233	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tmz1t_1234	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tmz1t_1235	COG0316	Belongs to the HesB IscA family
Tmz1t_1237	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tmz1t_1238	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tmz1t_1242	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tmz1t_1243	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Tmz1t_1244	COG2205	protein histidine kinase activity
Tmz1t_1245	COG0745	RESPONSE REGULATOR receiver
Tmz1t_1248	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tmz1t_1249	COG0542	response to heat
Tmz1t_1250	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tmz1t_1251	COG1278	Cold shock
Tmz1t_1252	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tmz1t_1253	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tmz1t_1254	COG2003	Belongs to the UPF0758 family
Tmz1t_1255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tmz1t_1256	COG0756	dUTP diphosphatase activity
Tmz1t_1260	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Tmz1t_1261	COG0538	isocitrate dehydrogenase activity
Tmz1t_1263	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tmz1t_1266	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tmz1t_1268	COG1346	cytolysis
Tmz1t_1271	COG0697	spore germination
Tmz1t_1272	COG0730	response to heat
Tmz1t_1275	COG2217	Heavy metal translocating P-type atpase
Tmz1t_1277	COG3278	Belongs to the heme-copper respiratory oxidase family
Tmz1t_1285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tmz1t_1288	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tmz1t_1289	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tmz1t_1292	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Tmz1t_1294	COG0469	pyruvate kinase activity
Tmz1t_1297	COG2084	Dehydrogenase
Tmz1t_1298	COG3622	Belongs to the hyi family
Tmz1t_1299	COG3960	tartronate-semialdehyde synthase activity
Tmz1t_1300	COG0583	DNA-binding transcription factor activity
Tmz1t_1301	COG0583	DNA-binding transcription factor activity
Tmz1t_1302	COG1473	amidohydrolase
Tmz1t_1307	COG2233	PERMEase
Tmz1t_1309	COG0697	spore germination
Tmz1t_1312	COG3851	Histidine kinase
Tmz1t_1313	COG4251	negative regulation of phosphorylation
Tmz1t_1314	COG0840	transmembrane signaling receptor activity
Tmz1t_1315	COG0745	RESPONSE REGULATOR receiver
Tmz1t_1318	COG0840	transmembrane signaling receptor activity
Tmz1t_1319	COG0835	chemotaxis
Tmz1t_1321	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tmz1t_1322	COG2201	protein-glutamate methylesterase activity
Tmz1t_1325	COG3447	MASE1 domain protein
Tmz1t_1325	COG5001	Diguanylate cyclase
Tmz1t_1325	COG5002	protein histidine kinase activity
Tmz1t_1327	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tmz1t_1329	COG3706	GGDEF domain
Tmz1t_1331	COG1131	(ABC) transporter
Tmz1t_1332	COG0842	Transport permease protein
Tmz1t_1333	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tmz1t_1334	COG0583	DNA-binding transcription factor activity
Tmz1t_1336	COG0402	S-adenosylhomocysteine deaminase activity
Tmz1t_1338	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Tmz1t_1340	COG2233	PERMEase
Tmz1t_1341	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
Tmz1t_1342	COG4266	Belongs to the allantoicase family
Tmz1t_1344	COG3195	allantoin biosynthetic process
Tmz1t_1344	COG3648	Uricase
Tmz1t_1348	COG0589	response to stress
Tmz1t_1349	COG0625	glutathione transferase activity
Tmz1t_1362	COG1230	cation diffusion facilitator family transporter
Tmz1t_1369	COG2205	protein histidine kinase activity
Tmz1t_1369	COG5002	protein histidine kinase activity
Tmz1t_1369	COG0784	Response regulator, receiver
Tmz1t_1371	COG0840	transmembrane signaling receptor activity
Tmz1t_1372	COG0326	Molecular chaperone. Has ATPase activity
Tmz1t_1374	COG1278	Cold shock
Tmz1t_1382	COG3706	GGDEF domain
Tmz1t_1382	COG0745	RESPONSE REGULATOR receiver
Tmz1t_1385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tmz1t_1386	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tmz1t_1389	COG2151	metal-sulfur cluster biosynthetic enzyme
Tmz1t_1395	COG0471	metal ion transport
Tmz1t_1395	COG3273	potassium ion transport
Tmz1t_1396	COG1218	3'(2'),5'-bisphosphate nucleotidase
Tmz1t_1397	COG0175	sulfate reduction
Tmz1t_1399	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tmz1t_1400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tmz1t_1401	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tmz1t_1402	COG0723	plastoquinol--plastocyanin reductase activity
Tmz1t_1403	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Tmz1t_1404	COG2857	Cytochrome c1
Tmz1t_1405	COG0625	glutathione transferase activity
Tmz1t_1406	COG2969	positive regulation of protein catabolic process
Tmz1t_1407	COG2703	oxygen carrier activity
Tmz1t_1408	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tmz1t_1409	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tmz1t_1411	COG0459	protein refolding
Tmz1t_1412	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmz1t_1413	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tmz1t_1414	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tmz1t_1414	COG0022	dehydrogenase e1 component
Tmz1t_1416	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tmz1t_1417	COG1067	ATP-dependent peptidase activity
Tmz1t_1419	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tmz1t_1420	COG0459	protein refolding
Tmz1t_1421	COG0745	RESPONSE REGULATOR receiver
Tmz1t_1422	COG0642	Histidine kinase
Tmz1t_1423	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tmz1t_1424	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tmz1t_1425	COG2890	protein-(glutamine-N5) methyltransferase activity
Tmz1t_1426	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Tmz1t_1432	COG2815	serine threonine protein kinase
Tmz1t_1432	COG0515	serine threonine protein kinase
Tmz1t_1433	COG0165	Argininosuccinate lyase
Tmz1t_1434	COG3275	phosphorelay sensor kinase activity
Tmz1t_1436	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tmz1t_1437	COG0181	hydroxymethylbilane synthase activity
Tmz1t_1439	COG2959	enzyme of heme biosynthesis
Tmz1t_1441	COG0408	coproporphyrinogen oxidase activity
Tmz1t_1442	COG0151	Belongs to the GarS family
Tmz1t_1443	COG0138	bifunctional purine biosynthesis protein purh
Tmz1t_1444	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Tmz1t_1448	COG2011	ABC-type metal ion transport system permease component
Tmz1t_1450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tmz1t_1451	COG0006	proline dipeptidase activity
Tmz1t_1454	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Tmz1t_1455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tmz1t_1456	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Tmz1t_1457	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tmz1t_1459	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tmz1t_1464	COG4191	Histidine kinase
Tmz1t_1473	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tmz1t_1474	COG0668	transmembrane transport
Tmz1t_1478	COG3119	arylsulfatase activity
Tmz1t_1479	COG0641	radical SAM
Tmz1t_1483	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tmz1t_1486	COG3485	protocatechuate 3,4-dioxygenase
Tmz1t_1493	COG1053	succinate dehydrogenase
Tmz1t_1494	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tmz1t_1495	COG0126	phosphoglycerate kinase activity
Tmz1t_1496	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tmz1t_1497	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tmz1t_1499	COG0483	inositol monophosphate 1-phosphatase activity
Tmz1t_1500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tmz1t_1501	COG0045	succinate-CoA ligase (ADP-forming) activity
Tmz1t_1501	COG1042	CoA-binding domain protein
Tmz1t_1501	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tmz1t_1502	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tmz1t_1503	COG2151	metal-sulfur cluster biosynthetic enzyme
Tmz1t_1504	COG3396	Phenylacetate-CoA oxygenase
Tmz1t_1505	COG3460	Phenylacetate-CoA oxygenase
Tmz1t_1506	COG3396	Phenylacetate-CoA oxygenase
Tmz1t_1508	COG0183	Belongs to the thiolase family
Tmz1t_1510	COG2050	protein possibly involved in aromatic compounds catabolism
Tmz1t_1511	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tmz1t_1512	COG1024	Enoyl-CoA hydratase
Tmz1t_1514	COG3327	negative regulation of DNA-templated transcription, initiation
Tmz1t_1515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Tmz1t_1519	COG0411	ABC transporter
Tmz1t_1522	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tmz1t_1522	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Tmz1t_1524	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Tmz1t_1526	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Tmz1t_1527	COG0303	'Molybdopterin
Tmz1t_1528	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tmz1t_1529	COG1333	cytochrome c biogenesis protein
Tmz1t_1531	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tmz1t_1535	COG2226	methyltransferase
Tmz1t_1536	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tmz1t_1538	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Tmz1t_1539	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tmz1t_1541	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Tmz1t_1543	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tmz1t_1544	COG0640	Transcriptional regulator
Tmz1t_1545	COG4942	peptidase
Tmz1t_1546	COG0793	Belongs to the peptidase S41A family
Tmz1t_1548	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tmz1t_1549	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tmz1t_1549	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tmz1t_1550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tmz1t_1551	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tmz1t_1554	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tmz1t_1558	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tmz1t_1559	COG0312	modulator of DNA gyrase
Tmz1t_1560	COG3028	Belongs to the UPF0307 family
Tmz1t_1561	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tmz1t_1563	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Tmz1t_1564	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Tmz1t_1565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tmz1t_1566	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tmz1t_1567	COG1132	(ABC) transporter
Tmz1t_1568	COG2096	Adenosyltransferase
Tmz1t_1571	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tmz1t_1574	COG0545	Peptidyl-prolyl cis-trans isomerase
Tmz1t_1576	COG0861	Integral membrane protein TerC family
Tmz1t_1577	COG1253	flavin adenine dinucleotide binding
Tmz1t_1578	COG0628	permease
Tmz1t_1579	COG1192	Involved in chromosome partitioning
Tmz1t_1580	COG0280	phosphate acetyltransferase
Tmz1t_1580	COG0281	malic enzyme
Tmz1t_1584	COG1254	Belongs to the acylphosphatase family
Tmz1t_1585	COG0659	secondary active sulfate transmembrane transporter activity
Tmz1t_1586	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tmz1t_1586	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tmz1t_1588	COG0489	protein tyrosine kinase activity
Tmz1t_1589	COG0717	Belongs to the dCTP deaminase family
Tmz1t_1590	COG1982	Orn Lys Arg decarboxylase major
Tmz1t_1592	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Tmz1t_1596	COG2030	dehydratase
Tmz1t_1597	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tmz1t_1598	COG3852	Histidine kinase
Tmz1t_1599	COG2204	response regulator
Tmz1t_1601	COG1196	nuclear chromosome segregation
Tmz1t_1601	COG0739	heme binding
Tmz1t_1601	COG0741	lytic transglycosylase activity
Tmz1t_1608	COG1704	LemA family
Tmz1t_1612	COG0604	alcohol dehydrogenase
Tmz1t_1614	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmz1t_1623	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tmz1t_1630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tmz1t_1631	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tmz1t_1632	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tmz1t_1633	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tmz1t_1637	COG0277	FAD linked oxidase domain protein
Tmz1t_1638	COG0277	FAD linked oxidase domain protein
Tmz1t_1639	COG0247	lactate metabolic process
Tmz1t_1640	COG0631	protein serine/threonine phosphatase activity
Tmz1t_1641	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tmz1t_1642	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tmz1t_1643	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Tmz1t_1645	COG5001	Diguanylate cyclase
Tmz1t_1645	COG3300	MHYT domain
Tmz1t_1646	COG0513	Belongs to the DEAD box helicase family
Tmz1t_1647	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Tmz1t_1648	COG0667	Aldo Keto reductase
Tmz1t_1651	COG0142	geranyltranstransferase activity
Tmz1t_1652	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Tmz1t_1653	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tmz1t_1655	COG0456	acetyltransferase
Tmz1t_1655	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Tmz1t_1658	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmz1t_1660	COG2902	Dehydrogenase
Tmz1t_1661	COG0504	CTP synthase activity
Tmz1t_1662	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Tmz1t_1663	COG0148	phosphopyruvate hydratase activity
Tmz1t_1664	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Tmz1t_1665	COG0791	NLP P60 protein
Tmz1t_1668	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Tmz1t_1670	COG0306	phosphate transporter
Tmz1t_1672	COG0302	gtp cyclohydrolase
Tmz1t_1674	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Tmz1t_1677	COG4681	YaeQ
Tmz1t_1678	COG0596	Alpha beta hydrolase
Tmz1t_1681	COG1278	Cold shock
Tmz1t_1683	COG0613	PHP domain protein
Tmz1t_1684	COG0009	L-threonylcarbamoyladenylate synthase
Tmz1t_1685	COG1994	Peptidase M50
Tmz1t_1686	COG0180	Tryptophanyl-tRNA synthetase
Tmz1t_1687	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tmz1t_1688	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tmz1t_1689	COG1187	pseudouridine synthase activity
Tmz1t_1690	COG0779	Required for maturation of 30S ribosomal subunits
Tmz1t_1691	COG2251	uridine kinase activity
Tmz1t_1691	COG0195	Participates in both transcription termination and antitermination
Tmz1t_1692	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tmz1t_1693	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tmz1t_1694	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tmz1t_1695	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tmz1t_1696	COG1185	polyribonucleotide nucleotidyltransferase activity
Tmz1t_1697	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tmz1t_1699	COG2032	superoxide dismutase activity
Tmz1t_1701	COG0584	glycerophosphoryl diester phosphodiesterase
Tmz1t_1704	COG2951	lytic endotransglycosylase activity
Tmz1t_1705	COG2186	Transcriptional regulator
Tmz1t_1711	COG1690	Belongs to the RtcB family
Tmz1t_1714	COG1620	l-lactate permease
Tmz1t_1715	COG0247	lactate metabolic process
Tmz1t_1716	COG1139	Iron-sulfur cluster binding protein
Tmz1t_1718	COG0045	succinate-CoA ligase (ADP-forming) activity
Tmz1t_1718	COG1042	CoA-binding domain protein
Tmz1t_1718	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tmz1t_1719	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tmz1t_1721	COG0402	S-adenosylhomocysteine deaminase activity
Tmz1t_1722	COG2815	serine threonine protein kinase
Tmz1t_1722	COG0515	serine threonine protein kinase
Tmz1t_1723	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Tmz1t_1724	COG1420	regulation of RNA biosynthetic process
Tmz1t_1725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tmz1t_1726	COG0497	DNA recombination
Tmz1t_1727	COG0735	belongs to the Fur family
Tmz1t_1728	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tmz1t_1729	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tmz1t_1731	COG0505	Belongs to the CarA family
Tmz1t_1732	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tmz1t_1733	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tmz1t_1734	COG1534	Rna-binding protein
Tmz1t_1735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Tmz1t_1736	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tmz1t_1737	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tmz1t_1738	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tmz1t_1740	COG0149	triose-phosphate isomerase activity
Tmz1t_1742	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tmz1t_1743	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tmz1t_1744	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tmz1t_1745	COG0649	NAD binding
Tmz1t_1746	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tmz1t_1748	COG1034	ATP synthesis coupled electron transport
Tmz1t_1749	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tmz1t_1750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tmz1t_1752	COG0713	ATP synthesis coupled electron transport
Tmz1t_1755	COG1007	ATP synthesis coupled electron transport
Tmz1t_1759	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tmz1t_1759	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tmz1t_1761	COG2840	Smr protein MutS2
Tmz1t_1762	COG0492	ferredoxin-NADP+ reductase activity
Tmz1t_1764	COG1674	ftsk spoiiie
Tmz1t_1765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Tmz1t_1766	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tmz1t_1768	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tmz1t_1769	COG0484	heat shock protein binding
Tmz1t_1772	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tmz1t_1773	COG1469	GTP cyclohydrolase I activity
Tmz1t_1774	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tmz1t_1775	COG0142	geranyltranstransferase activity
Tmz1t_1776	COG1722	exodeoxyribonuclease VII activity
Tmz1t_1778	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tmz1t_1779	COG1047	Peptidyl-prolyl cis-trans
Tmz1t_1780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tmz1t_1781	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tmz1t_1782	COG0196	riboflavin kinase activity
Tmz1t_1783	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tmz1t_1784	COG0802	atpase or kinase
Tmz1t_1789	COG3033	Beta-eliminating lyase
Tmz1t_1790	COG3045	CreA protein
Tmz1t_1793	COG0826	peptidase U32
Tmz1t_1796	COG2133	pyrroloquinoline quinone binding
Tmz1t_1797	COG0515	serine threonine protein kinase
Tmz1t_1799	COG3108	Peptidase M15
Tmz1t_1800	COG2989	Protein conserved in bacteria
Tmz1t_1804	COG4771	TonB-dependent receptor
Tmz1t_1807	COG1116	anion transmembrane transporter activity
Tmz1t_1815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmz1t_1816	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tmz1t_1817	COG2841	Protein conserved in bacteria
Tmz1t_1819	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tmz1t_1822	COG1238	metal cluster binding
Tmz1t_1823	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tmz1t_1824	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tmz1t_1826	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tmz1t_1826	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tmz1t_1827	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Tmz1t_1829	COG0720	synthase
Tmz1t_1832	COG0527	aspartate kinase activity
Tmz1t_1834	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tmz1t_1834	COG1199	ATP-dependent helicase activity
Tmz1t_1836	COG0443	Heat shock 70 kDa protein
Tmz1t_1839	COG1012	belongs to the aldehyde dehydrogenase family
Tmz1t_1843	COG2204	response regulator
Tmz1t_1846	COG1716	ATPase activity
Tmz1t_1846	COG5001	Diguanylate cyclase
Tmz1t_1847	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tmz1t_1848	COG1074	ATP-dependent DNA helicase activity
Tmz1t_1849	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Tmz1t_1853	COG0798	PFAM Bile acid sodium symporter
Tmz1t_1854	COG1595	DNA-templated transcription, initiation
Tmz1t_1857	COG1064	alcohol dehydrogenase
Tmz1t_1859	COG2353	YceI-like domain
Tmz1t_1861	COG3038	cytochrome b561
Tmz1t_1886	COG0583	DNA-binding transcription factor activity
Tmz1t_1887	COG3384	dioxygenase
Tmz1t_1888	COG0400	carboxylic ester hydrolase activity
Tmz1t_1895	COG0822	iron-sulfur transferase activity
Tmz1t_1896	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tmz1t_1897	COG0719	Fe-S assembly protein
Tmz1t_1898	COG0396	ATPase activity
Tmz1t_1899	COG0719	Fe-S assembly protein
Tmz1t_1903	COG2363	Small membrane protein
Tmz1t_1904	COG0625	glutathione transferase activity
Tmz1t_1905	COG1490	D-aminoacyl-tRNA deacylase activity
Tmz1t_1907	COG3706	GGDEF domain
Tmz1t_1911	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tmz1t_1913	COG0745	RESPONSE REGULATOR receiver
Tmz1t_1914	COG2205	protein histidine kinase activity
Tmz1t_1915	COG1309	transcriptional regulator
Tmz1t_1918	COG0577	efflux transmembrane transporter activity
Tmz1t_1918	COG1136	(ABC) transporter
Tmz1t_1923	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tmz1t_1925	COG1858	cytochrome C peroxidase
Tmz1t_1928	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tmz1t_1930	COG5002	protein histidine kinase activity
Tmz1t_1931	COG2194	sulfuric ester hydrolase activity
Tmz1t_1940	COG0745	RESPONSE REGULATOR receiver
Tmz1t_1941	COG0642	Histidine kinase
Tmz1t_1945	COG2814	Major facilitator Superfamily
Tmz1t_1948	COG0587	DNA-directed DNA polymerase activity
Tmz1t_1950	COG4120	Belongs to the binding-protein-dependent transport system permease family
Tmz1t_1951	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Tmz1t_1952	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tmz1t_1954	COG2197	response regulator
Tmz1t_1956	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Tmz1t_1956	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tmz1t_1957	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tmz1t_1959	COG1196	nuclear chromosome segregation
Tmz1t_1960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tmz1t_1966	COG0022	dehydrogenase e1 component
Tmz1t_1972	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tmz1t_1982	COG2226	methyltransferase
Tmz1t_1984	COG1032	radical SAM domain protein
Tmz1t_1987	COG1136	(ABC) transporter
Tmz1t_1992	COG1162	GTPase activity
Tmz1t_1993	COG0501	Belongs to the peptidase M48B family
Tmz1t_1994	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Tmz1t_1997	COG0254	rRNA binding
Tmz1t_1998	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tmz1t_1999	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Tmz1t_2000	COG3318	Belongs to the UPF0149 family
Tmz1t_2000	COG3012	SEC-C Motif Domain Protein
Tmz1t_2006	COG3012	SEC-C Motif Domain Protein
Tmz1t_2007	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tmz1t_2021	COG0723	plastoquinol--plastocyanin reductase activity
Tmz1t_2022	COG1242	4 iron, 4 sulfur cluster binding
Tmz1t_2031	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tmz1t_2034	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tmz1t_2036	COG0850	regulation of cytokinetic process
Tmz1t_2037	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tmz1t_2038	COG1393	Belongs to the ArsC family
Tmz1t_2039	COG2183	response to ionizing radiation
Tmz1t_2041	COG1042	CoA-binding domain protein
Tmz1t_2041	COG0045	succinate-CoA ligase (ADP-forming) activity
Tmz1t_2041	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tmz1t_2042	COG2202	Pas domain
Tmz1t_2042	COG2205	protein histidine kinase activity
Tmz1t_2043	COG0297	glycogen (starch) synthase activity
Tmz1t_2044	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Tmz1t_2046	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tmz1t_2047	COG0837	glucose binding
Tmz1t_2048	COG0366	Alpha amylase catalytic
Tmz1t_2049	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tmz1t_2050	COG1879	ABC-type sugar transport system periplasmic component
Tmz1t_2061	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tmz1t_2064	COG0583	DNA-binding transcription factor activity
Tmz1t_2070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tmz1t_2072	COG1538	Outer membrane efflux protein
Tmz1t_2074	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmz1t_2078	COG4569	acetaldehyde dehydrogenase (acetylating) activity
Tmz1t_2079	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmz1t_2090	COG4584	PFAM Integrase catalytic
Tmz1t_2102	COG5002	protein histidine kinase activity
Tmz1t_2104	COG0789	Transcriptional regulator
Tmz1t_2122	COG3293	Transposase
Tmz1t_2125	COG1199	ATP-dependent helicase activity
Tmz1t_2125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tmz1t_2130	COG1690	Belongs to the RtcB family
Tmz1t_2132	COG1418	mRNA catabolic process
Tmz1t_2135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Tmz1t_2137	COG0662	Cupin 2, conserved barrel domain protein
Tmz1t_2137	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Tmz1t_2146	COG3041	Addiction module toxin RelE StbE family
Tmz1t_2147	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tmz1t_2154	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tmz1t_2157	COG1562	ergosterol biosynthetic process
Tmz1t_2159	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Tmz1t_2160	COG2866	Carboxypeptidase
Tmz1t_2161	COG3022	response to hydroperoxide
Tmz1t_2163	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tmz1t_2164	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tmz1t_2165	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tmz1t_2166	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tmz1t_2167	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tmz1t_2168	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tmz1t_2172	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tmz1t_2173	COG0575	Belongs to the CDS family
Tmz1t_2174	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tmz1t_2175	COG0233	cytoplasmic translational termination
Tmz1t_2176	COG0528	UMP kinase activity
Tmz1t_2177	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tmz1t_2178	COG0052	Belongs to the universal ribosomal protein uS2 family
Tmz1t_2179	COG0024	Methionine aminopeptidase
Tmz1t_2180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Tmz1t_2181	COG2862	Uncharacterized protein family, UPF0114
Tmz1t_2182	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tmz1t_2187	COG1858	cytochrome C peroxidase
Tmz1t_2188	COG1858	cytochrome C peroxidase
Tmz1t_2189	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tmz1t_2190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tmz1t_2192	COG1196	nuclear chromosome segregation
Tmz1t_2194	COG2171	N-acyltransferase activity
Tmz1t_2196	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tmz1t_2198	COG2201	protein-glutamate methylesterase activity
Tmz1t_2201	COG0443	Heat shock 70 kDa protein
Tmz1t_2202	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Tmz1t_2204	COG0822	iron-sulfur transferase activity
Tmz1t_2205	COG1104	cysteine desulfurase activity
Tmz1t_2206	COG1104	cysteine desulfurase activity
Tmz1t_2207	COG1959	2 iron, 2 sulfur cluster binding
Tmz1t_2208	COG1045	serine acetyltransferase
Tmz1t_2209	COG3228	Belongs to the MtfA family
Tmz1t_2213	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tmz1t_2214	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tmz1t_2215	COG1355	regulation of microtubule-based process
Tmz1t_2220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tmz1t_2221	COG0598	Magnesium transport protein CorA
Tmz1t_2223	COG0348	domain, Protein
Tmz1t_2226	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tmz1t_2227	COG2818	Glycosylase
Tmz1t_2234	COG1518	maintenance of DNA repeat elements
Tmz1t_2236	COG0300	oxidoreductase activity
Tmz1t_2239	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tmz1t_2240	COG0560	Phosphoserine phosphatase
Tmz1t_2241	COG4181	ATPase activity
Tmz1t_2243	COG0709	Synthesizes selenophosphate from selenide and ATP
Tmz1t_2244	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Tmz1t_2246	COG0058	SHG alpha-glucan phosphorylase activity
Tmz1t_2247	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tmz1t_2248	COG3383	formate dehydrogenase (NAD+) activity
Tmz1t_2249	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Tmz1t_2250	COG3259	Nickel-dependent hydrogenase
Tmz1t_2254	COG0477	Major facilitator Superfamily
Tmz1t_2259	COG0745	RESPONSE REGULATOR receiver
Tmz1t_2260	COG2205	protein histidine kinase activity
Tmz1t_2261	COG2917	probably involved in intracellular septation
Tmz1t_2262	COG2350	Protein conserved in bacteria
Tmz1t_2264	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tmz1t_2265	COG1960	acyl-CoA dehydrogenase activity
Tmz1t_2271	COG0084	hydrolase, TatD family'
Tmz1t_2272	COG1024	Enoyl-CoA hydratase
Tmz1t_2273	COG3706	GGDEF domain
Tmz1t_2276	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Tmz1t_2277	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tmz1t_2278	COG0248	Ppx GppA phosphatase
Tmz1t_2279	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Tmz1t_2280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tmz1t_2284	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tmz1t_2287	COG4109	DRTGG domain
Tmz1t_2288	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tmz1t_2289	COG0328	RNA-DNA hybrid ribonuclease activity
Tmz1t_2290	COG2226	methyltransferase
Tmz1t_2292	COG1388	LysM domain
Tmz1t_2292	COG0741	lytic transglycosylase activity
Tmz1t_2294	COG1047	Peptidyl-prolyl cis-trans
Tmz1t_2297	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tmz1t_2299	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tmz1t_2306	COG0322	excinuclease ABC activity
Tmz1t_2307	COG1472	Belongs to the glycosyl hydrolase 3 family
Tmz1t_2308	COG0736	holo-[acyl-carrier-protein] synthase activity
Tmz1t_2309	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Tmz1t_2310	COG1381	Involved in DNA repair and RecF pathway recombination
Tmz1t_2311	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tmz1t_2312	COG0571	ribonuclease III activity
Tmz1t_2314	COG0681	Belongs to the peptidase S26 family
Tmz1t_2315	COG0481	GTPase activity
Tmz1t_2317	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tmz1t_2322	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tmz1t_2325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tmz1t_2328	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tmz1t_2331	COG0706	membrane insertase activity
Tmz1t_2332	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tmz1t_2333	COG0594	ribonuclease P activity
Tmz1t_2334	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Tmz1t_2340	COG1525	nuclease
Tmz1t_2344	COG2135	peptidase activity
Tmz1t_2347	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tmz1t_2360	COG2135	peptidase activity
Tmz1t_2362	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tmz1t_2364	COG1525	nuclease
Tmz1t_2372	COG3727	T/G mismatch-specific endonuclease activity
Tmz1t_2374	COG1192	Involved in chromosome partitioning
Tmz1t_2389	COG5002	protein histidine kinase activity
Tmz1t_2391	COG0789	Transcriptional regulator
Tmz1t_2401	COG1192	Involved in chromosome partitioning
Tmz1t_2413	COG4974	Belongs to the 'phage' integrase family
Tmz1t_2429	COG0416	fatty acid biosynthetic process
Tmz1t_2430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tmz1t_2431	COG1399	metal-binding, possibly nucleic acid-binding protein
Tmz1t_2432	COG0424	maF-like protein
Tmz1t_2436	COG1530	ribonuclease E activity
Tmz1t_2437	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tmz1t_2438	COG0556	nucleotide-excision repair
Tmz1t_2441	COG2212	antiporter activity
Tmz1t_2442	COG1863	multisubunit Na H antiporter MnhE subunit
Tmz1t_2443	COG0651	ATP synthesis coupled electron transport
Tmz1t_2444	COG1006	Multisubunit Na H antiporter MnhC subunit
Tmz1t_2445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tmz1t_2445	COG2111	Na H antiporter
Tmz1t_2446	COG3040	lipid binding
Tmz1t_2447	COG3647	Membrane
Tmz1t_2449	COG1067	ATP-dependent peptidase activity
Tmz1t_2450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tmz1t_2455	COG0297	glycogen (starch) synthase activity
Tmz1t_2459	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tmz1t_2459	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tmz1t_2465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Tmz1t_2466	COG1473	amidohydrolase
Tmz1t_2467	COG0513	Belongs to the DEAD box helicase family
Tmz1t_2474	COG0411	ABC transporter
Tmz1t_2481	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Tmz1t_2482	COG1278	Cold shock
Tmz1t_2486	COG1902	pentaerythritol trinitrate reductase activity
Tmz1t_2488	COG1960	acyl-CoA dehydrogenase activity
Tmz1t_2491	COG0183	Belongs to the thiolase family
Tmz1t_2492	COG1024	Enoyl-CoA hydratase
Tmz1t_2493	COG0318	PFAM AMP-dependent synthetase and ligase
Tmz1t_2495	COG1309	transcriptional regulator
Tmz1t_2497	COG1902	pentaerythritol trinitrate reductase activity
Tmz1t_2497	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tmz1t_2498	COG2824	Alkylphosphonate utilization operon protein PhnA
Tmz1t_2500	COG0084	hydrolase, TatD family'
Tmz1t_2503	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tmz1t_2504	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tmz1t_2508	COG1376	ErfK ybiS ycfS ynhG family protein
Tmz1t_2509	COG0590	tRNA wobble adenosine to inosine editing
Tmz1t_2510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tmz1t_2519	COG1704	LemA family
Tmz1t_2523	COG0314	molybdopterin synthase activity
Tmz1t_2524	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Tmz1t_2525	COG0303	'Molybdopterin
Tmz1t_2526	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tmz1t_2527	COG1199	ATP-dependent helicase activity
Tmz1t_2541	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Tmz1t_2542	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tmz1t_2543	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tmz1t_2544	COG0567	Dehydrogenase, E1 component
Tmz1t_2546	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Tmz1t_2547	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tmz1t_2548	COG1053	succinate dehydrogenase
Tmz1t_2551	COG2188	Transcriptional regulator
Tmz1t_2552	COG0039	L-malate dehydrogenase activity
Tmz1t_2554	COG0583	DNA-binding transcription factor activity
Tmz1t_2555	COG2814	Major facilitator Superfamily
Tmz1t_2560	COG4215	(ABC) transporter
Tmz1t_2561	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tmz1t_2562	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tmz1t_2563	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tmz1t_2564	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tmz1t_2565	COG0740	serine-type endopeptidase activity
Tmz1t_2566	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tmz1t_2567	COG2766	serine protein kinase
Tmz1t_2568	COG2718	Belongs to the UPF0229 family
Tmz1t_2569	COG2719	SpoVR family
Tmz1t_2570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tmz1t_2570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tmz1t_2575	COG3360	Dodecin
Tmz1t_2577	COG2258	MOSC domain
Tmz1t_2579	COG0436	Aminotransferase
Tmz1t_2581	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tmz1t_2582	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Tmz1t_2585	COG0791	NLP P60 protein
Tmz1t_2587	COG1840	ABC-type Fe3 transport system, periplasmic component
Tmz1t_2588	COG0745	RESPONSE REGULATOR receiver
Tmz1t_2588	COG3706	GGDEF domain
Tmz1t_2589	COG1178	ABC-type Fe3 transport system permease component
Tmz1t_2590	COG3842	ATPase activity
Tmz1t_2591	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Tmz1t_2592	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Tmz1t_2593	COG0167	dihydroorotate dehydrogenase activity
Tmz1t_2597	COG2010	Cytochrome c
Tmz1t_2600	COG1845	cytochrome c oxidase, subunit III
Tmz1t_2603	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tmz1t_2609	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tmz1t_2614	COG2010	Cytochrome c
Tmz1t_2618	COG2010	Cytochrome c
Tmz1t_2619	COG1648	precorrin-2 dehydrogenase activity
Tmz1t_2619	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tmz1t_2622	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tmz1t_2622	COG0519	Catalyzes the synthesis of GMP from XMP
Tmz1t_2625	COG2914	Belongs to the UPF0125 (RnfH) family
Tmz1t_2627	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tmz1t_2630	COG2197	response regulator
Tmz1t_2631	COG3850	Histidine kinase
Tmz1t_2632	COG2181	nitrate reductase activity
Tmz1t_2633	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Tmz1t_2635	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Tmz1t_2639	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Tmz1t_2640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tmz1t_2641	COG0601	transmembrane transport
Tmz1t_2644	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tmz1t_2646	COG0542	response to heat
Tmz1t_2647	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tmz1t_2648	COG2176	DNA-directed DNA polymerase activity
Tmz1t_2648	COG5002	protein histidine kinase activity
Tmz1t_2649	COG0745	RESPONSE REGULATOR receiver
Tmz1t_2650	COG5002	protein histidine kinase activity
Tmz1t_2652	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmz1t_2656	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tmz1t_2658	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tmz1t_2659	COG0183	Belongs to the thiolase family
Tmz1t_2660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Tmz1t_2671	COG1666	GTP binding
Tmz1t_2672	COG3123	guanosine phosphorylase activity
Tmz1t_2674	COG0137	argininosuccinate synthase activity
Tmz1t_2675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tmz1t_2676	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tmz1t_2678	COG0268	Binds directly to 16S ribosomal RNA
Tmz1t_2679	COG0728	peptidoglycan biosynthetic process
Tmz1t_2680	COG0583	DNA-binding transcription factor activity
Tmz1t_2683	COG0386	Belongs to the glutathione peroxidase family
Tmz1t_2686	COG0488	(ABC) transporter
Tmz1t_2693	COG4964	Belongs to the GSP D family
Tmz1t_2699	COG3209	COG3209 Rhs family protein
Tmz1t_2701	COG0697	spore germination
Tmz1t_2703	COG5433	transposase activity
Tmz1t_2710	COG2201	protein-glutamate methylesterase activity
Tmz1t_2730	COG3005	denitrification pathway
Tmz1t_2737	COG1595	DNA-templated transcription, initiation
Tmz1t_2749	COG0033	Phosphoglucomutase
Tmz1t_2758	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tmz1t_2759	COG0628	permease
Tmz1t_2760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tmz1t_2762	COG0617	tRNA 3'-terminal CCA addition
Tmz1t_2765	COG1428	Deoxynucleoside kinase
Tmz1t_2766	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tmz1t_2767	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tmz1t_2768	COG0516	GMP reductase activity
Tmz1t_2768	COG0517	IMP dehydrogenase activity
Tmz1t_2769	COG0308	aminopeptidase N
Tmz1t_2771	COG4651	solute:proton antiporter activity
Tmz1t_2771	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Tmz1t_2773	COG0028	Belongs to the TPP enzyme family
Tmz1t_2774	COG0440	acetolactate synthase activity
Tmz1t_2775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tmz1t_2776	COG1183	phosphatidylcholine synthase activity
Tmz1t_2777	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmz1t_2781	COG0228	four-way junction DNA binding
Tmz1t_2782	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tmz1t_2783	COG0336	Belongs to the RNA methyltransferase TrmD family
Tmz1t_2784	COG0335	large ribosomal subunit rRNA binding
Tmz1t_2785	COG0795	lipopolysaccharide-transporting ATPase activity
Tmz1t_2786	COG0795	lipopolysaccharide-transporting ATPase activity
Tmz1t_2787	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tmz1t_2790	COG0525	valine-tRNA ligase activity
Tmz1t_2791	COG0425	Belongs to the sulfur carrier protein TusA family
Tmz1t_2792	COG4783	chaperone-mediated protein folding
Tmz1t_2793	COG0315	cyclic pyranopterin monophosphate synthase activity
Tmz1t_2805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tmz1t_2810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tmz1t_2811	COG2414	aldehyde ferredoxin oxidoreductase
Tmz1t_2813	COG3284	Transcriptional regulator
Tmz1t_2823	COG3383	formate dehydrogenase (NAD+) activity
Tmz1t_2826	COG4591	ABC-type transport system involved in lipoprotein release permease component
Tmz1t_2827	COG1136	(ABC) transporter
Tmz1t_2831	COG0784	Response regulator, receiver
Tmz1t_2831	COG2205	protein histidine kinase activity
Tmz1t_2831	COG2198	Histidine kinase
Tmz1t_2832	COG3706	GGDEF domain
Tmz1t_2833	COG3437	response regulator, receiver
Tmz1t_2836	COG0535	radical SAM domain protein
Tmz1t_2839	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Tmz1t_2840	COG0167	dihydroorotate dehydrogenase activity
Tmz1t_2849	COG1131	(ABC) transporter
Tmz1t_2850	COG1116	anion transmembrane transporter activity
Tmz1t_2857	COG3963	phosphatidate phosphatase activity
Tmz1t_2858	COG2354	Protein conserved in bacteria
Tmz1t_2868	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Tmz1t_2869	COG4772	TonB-dependent receptor
Tmz1t_2870	COG3284	Transcriptional regulator
Tmz1t_2872	COG1012	belongs to the aldehyde dehydrogenase family
Tmz1t_2874	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tmz1t_2879	COG0028	Belongs to the TPP enzyme family
Tmz1t_2880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tmz1t_2884	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tmz1t_2887	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tmz1t_2889	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tmz1t_2893	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tmz1t_2894	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
Tmz1t_2895	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
Tmz1t_2896	COG1677	Flagellar hook-basal body complex protein FliE
Tmz1t_2897	COG2204	response regulator
Tmz1t_2898	COG3852	Histidine kinase
Tmz1t_2899	COG1766	The M ring may be actively involved in energy transduction
Tmz1t_2900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmz1t_2901	COG5433	transposase activity
Tmz1t_2903	COG1157	protein secretion by the type III secretion system
Tmz1t_2907	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmz1t_2911	COG1987	bacterial-type flagellum assembly
Tmz1t_2914	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tmz1t_2915	COG1256	bacterial-type flagellum assembly
Tmz1t_2916	COG1705	Flagellar rod assembly protein muramidase FlgJ
Tmz1t_2916	COG3951	Flagellar rod assembly protein muramidase FlgJ
Tmz1t_2917	COG1706	bacterial-type flagellum-dependent cell motility
Tmz1t_2918	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Tmz1t_2919	COG4786	Flagellar basal body rod
Tmz1t_2920	COG4787	bacterial-type flagellum-dependent cell motility
Tmz1t_2921	COG1749	Flagellar hook protein flgE
Tmz1t_2922	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tmz1t_2923	COG1558	bacterial-type flagellum-dependent cell motility
Tmz1t_2924	COG1815	bacterial-type flagellum-dependent cell motility
Tmz1t_2928	COG0187	DNA topoisomerase II activity
Tmz1t_2933	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Tmz1t_2938	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tmz1t_2941	COG0411	ABC transporter
Tmz1t_2944	COG1028	Short-chain dehydrogenase reductase Sdr
Tmz1t_2947	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tmz1t_2955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tmz1t_2955	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tmz1t_2956	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tmz1t_2958	COG0517	IMP dehydrogenase activity
Tmz1t_2959	COG0243	molybdopterin cofactor binding
Tmz1t_2960	COG0437	4 iron, 4 sulfur cluster binding
Tmz1t_2989	COG4657	Part of a membrane complex involved in electron transport
Tmz1t_2990	COG2878	Part of a membrane complex involved in electron transport
Tmz1t_2992	COG4658	electron transport chain
Tmz1t_2996	COG0789	Transcriptional regulator
Tmz1t_3001	COG0011	TIGRFAM Protein of
Tmz1t_3004	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tmz1t_3006	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Tmz1t_3007	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tmz1t_3008	COG0123	including yeast histone deacetylase and acetoin utilization protein
Tmz1t_3009	COG0714	Associated with various cellular activities
Tmz1t_3012	COG2951	lytic endotransglycosylase activity
Tmz1t_3016	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tmz1t_3017	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tmz1t_3019	COG0776	regulation of translation
Tmz1t_3020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tmz1t_3020	COG0072	phenylalanine-tRNA ligase activity
Tmz1t_3021	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tmz1t_3022	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tmz1t_3023	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tmz1t_3024	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tmz1t_3025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tmz1t_3032	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Tmz1t_3034	COG0776	regulation of translation
Tmz1t_3036	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tmz1t_3037	COG0287	Prephenate dehydrogenase
Tmz1t_3042	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tmz1t_3043	COG0443	Heat shock 70 kDa protein
Tmz1t_3044	COG0484	heat shock protein binding
Tmz1t_3046	COG0215	cysteine-tRNA ligase activity
Tmz1t_3047	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tmz1t_3048	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tmz1t_3049	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tmz1t_3053	COG1794	racemase activity, acting on amino acids and derivatives
Tmz1t_3054	COG4636	protein conserved in cyanobacteria
Tmz1t_3059	COG0285	dihydrofolate synthase activity
Tmz1t_3061	COG0159	tryptophan synthase activity
Tmz1t_3062	COG0133	tryptophan synthase activity
Tmz1t_3063	COG0135	phosphoribosylanthranilate isomerase activity
Tmz1t_3064	COG0101	tRNA pseudouridine synthase activity
Tmz1t_3068	COG0473	3-isopropylmalate dehydrogenase activity
Tmz1t_3069	COG0066	3-isopropylmalate dehydratase activity
Tmz1t_3071	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tmz1t_3072	COG0501	Belongs to the peptidase M48B family
Tmz1t_3073	COG2814	Major facilitator Superfamily
Tmz1t_3074	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tmz1t_3075	COG0440	acetolactate synthase activity
Tmz1t_3076	COG0028	Belongs to the TPP enzyme family
Tmz1t_3077	COG0318	PFAM AMP-dependent synthetase and ligase
Tmz1t_3081	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tmz1t_3082	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tmz1t_3083	COG1802	Transcriptional regulator
Tmz1t_3086	COG0411	ABC transporter
Tmz1t_3105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmz1t_3106	COG4569	acetaldehyde dehydrogenase (acetylating) activity
Tmz1t_3108	COG1802	Transcriptional regulator
Tmz1t_3118	COG0277	FAD linked oxidase domain protein
Tmz1t_3119	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tmz1t_3120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmz1t_3121	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Tmz1t_3123	COG1028	Short-chain dehydrogenase reductase Sdr
Tmz1t_3124	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tmz1t_3127	COG0564	pseudouridine synthase activity
Tmz1t_3129	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Tmz1t_3132	COG0411	ABC transporter
Tmz1t_3133	COG4214	carbohydrate transport
Tmz1t_3134	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tmz1t_3137	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tmz1t_3139	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
Tmz1t_3143	COG0745	RESPONSE REGULATOR receiver
Tmz1t_3143	COG3706	GGDEF domain
Tmz1t_3145	COG0668	transmembrane transport
Tmz1t_3149	COG4628	conserved protein (DUF2132)
Tmz1t_3150	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tmz1t_3151	COG5433	transposase activity
Tmz1t_3155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tmz1t_3159	COG4584	PFAM Integrase catalytic
Tmz1t_3166	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Tmz1t_3168	COG2801	Transposase and inactivated derivatives
Tmz1t_3171	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tmz1t_3187	COG0009	L-threonylcarbamoyladenylate synthase
Tmz1t_3188	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Tmz1t_3189	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tmz1t_3190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tmz1t_3192	COG4566	intracellular signal transduction
Tmz1t_3195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Tmz1t_3196	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tmz1t_3197	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tmz1t_3203	COG0047	phosphoribosylformylglycinamidine synthase activity
Tmz1t_3203	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tmz1t_3205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tmz1t_3206	COG0509	glycine decarboxylation via glycine cleavage system
Tmz1t_3207	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tmz1t_3207	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tmz1t_3209	COG1215	transferase activity, transferring glycosyl groups
Tmz1t_3210	COG0471	metal ion transport
Tmz1t_3212	COG0563	adenylate kinase activity
Tmz1t_3213	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Tmz1t_3214	COG2835	tetraacyldisaccharide 4'-kinase activity
Tmz1t_3215	COG1663	tetraacyldisaccharide 4'-kinase activity
Tmz1t_3216	COG0848	biopolymer transport protein
Tmz1t_3217	COG0811	peptide transport
Tmz1t_3218	COG1570	exodeoxyribonuclease VII activity
Tmz1t_3219	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tmz1t_3220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tmz1t_3221	COG0643	Histidine kinase
Tmz1t_3221	COG2198	Histidine kinase
Tmz1t_3222	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Tmz1t_3223	COG0745	RESPONSE REGULATOR receiver
Tmz1t_3224	COG0835	chemotaxis
Tmz1t_3224	COG0784	Response regulator, receiver
Tmz1t_3225	COG0784	Response regulator, receiver
Tmz1t_3225	COG0835	chemotaxis
Tmz1t_3226	COG1360	Flagellar Motor Protein
Tmz1t_3227	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Tmz1t_3230	COG0745	RESPONSE REGULATOR receiver
Tmz1t_3230	COG3706	GGDEF domain
Tmz1t_3232	COG4657	Part of a membrane complex involved in electron transport
Tmz1t_3233	COG2878	Part of a membrane complex involved in electron transport
Tmz1t_3235	COG4658	electron transport chain
Tmz1t_3236	COG4659	FMN binding
Tmz1t_3238	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tmz1t_3241	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tmz1t_3246	COG3754	Rhamnan synthesis protein F
Tmz1t_3247	COG0367	asparagine synthase
Tmz1t_3248	COG1215	transferase activity, transferring glycosyl groups
Tmz1t_3250	COG1215	transferase activity, transferring glycosyl groups
Tmz1t_3252	COG1216	Glycosyl transferase, family 2
Tmz1t_3256	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tmz1t_3262	COG1696	Membrane protein involved in D-alanine export
Tmz1t_3263	COG0297	glycogen (starch) synthase activity
Tmz1t_3267	COG0463	Glycosyl transferase, family 2
Tmz1t_3269	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Tmz1t_3271	COG0438	transferase activity, transferring glycosyl groups
Tmz1t_3272	COG0367	asparagine synthase
Tmz1t_3273	COG0438	transferase activity, transferring glycosyl groups
Tmz1t_3274	COG0438	transferase activity, transferring glycosyl groups
Tmz1t_3278	COG3267	Type II secretory pathway component ExeA
Tmz1t_3278	COG3409	Peptidoglycan-binding domain 1 protein
Tmz1t_3280	COG0489	protein tyrosine kinase activity
Tmz1t_3285	COG1136	(ABC) transporter
Tmz1t_3285	COG0577	efflux transmembrane transporter activity
Tmz1t_3287	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tmz1t_3291	COG0436	Aminotransferase
Tmz1t_3292	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tmz1t_3293	COG0235	Class ii aldolase
Tmz1t_3294	COG2084	Dehydrogenase
Tmz1t_3295	COG2084	Dehydrogenase
Tmz1t_3296	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tmz1t_3298	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Tmz1t_3299	COG0583	DNA-binding transcription factor activity
Tmz1t_3300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tmz1t_3303	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmz1t_3305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tmz1t_3308	COG2814	Major facilitator Superfamily
Tmz1t_3310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tmz1t_3311	COG0203	ribosomal protein L17
Tmz1t_3312	COG0202	RNA polymerase activity
Tmz1t_3313	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tmz1t_3314	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tmz1t_3315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tmz1t_3316	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tmz1t_3317	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tmz1t_3318	COG0201	protein transport
Tmz1t_3319	COG0200	Binds to the 23S rRNA
Tmz1t_3320	COG1841	ribosomal large subunit assembly
Tmz1t_3321	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tmz1t_3322	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tmz1t_3323	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tmz1t_3324	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tmz1t_3325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tmz1t_3326	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tmz1t_3327	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tmz1t_3328	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tmz1t_3329	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tmz1t_3330	COG0255	Belongs to the universal ribosomal protein uL29 family
Tmz1t_3331	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tmz1t_3332	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tmz1t_3333	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tmz1t_3334	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tmz1t_3335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tmz1t_3336	COG0089	rRNA binding
Tmz1t_3337	COG0088	Forms part of the polypeptide exit tunnel
Tmz1t_3338	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tmz1t_3339	COG0051	transcription antitermination factor activity, RNA binding
Tmz1t_3340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tmz1t_3341	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tmz1t_3342	COG0049	tRNA binding
Tmz1t_3343	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tmz1t_3344	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tmz1t_3345	COG0085	RNA polymerase activity
Tmz1t_3346	COG0222	ribosome binding
Tmz1t_3347	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tmz1t_3348	COG0081	regulation of translation
Tmz1t_3349	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tmz1t_3351	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tmz1t_3352	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tmz1t_3356	COG4999	Histidine kinase
Tmz1t_3356	COG2205	protein histidine kinase activity
Tmz1t_3356	COG3850	Histidine kinase
Tmz1t_3356	COG3437	response regulator, receiver
Tmz1t_3358	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tmz1t_3359	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Tmz1t_3363	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tmz1t_3365	COG1022	Amp-dependent synthetase and ligase
Tmz1t_3371	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tmz1t_3371	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tmz1t_3371	COG1703	isobutyryl-CoA mutase activity
Tmz1t_3377	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tmz1t_3378	COG0557	exoribonuclease II activity
Tmz1t_3379	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tmz1t_3380	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Tmz1t_3382	COG0330	HflC and HflK could
Tmz1t_3383	COG0330	HflC and HflK could
Tmz1t_3384	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tmz1t_3385	COG1923	regulation of RNA biosynthetic process
Tmz1t_3386	COG1160	GTP binding
Tmz1t_3387	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tmz1t_3389	COG0124	histidyl-tRNA synthetase
Tmz1t_3390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tmz1t_3391	COG1426	Protein conserved in bacteria
Tmz1t_3393	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tmz1t_3394	COG0105	UTP biosynthetic process
Tmz1t_3395	COG0586	Pfam SNARE associated Golgi protein
Tmz1t_3401	COG0037	tRNA processing
Tmz1t_3402	COG0825	malonyl-CoA metabolic process
Tmz1t_3405	COG0583	DNA-binding transcription factor activity
Tmz1t_3406	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tmz1t_3407	COG0343	queuine tRNA-ribosyltransferase activity
Tmz1t_3408	COG1862	Preprotein translocase
Tmz1t_3409	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tmz1t_3410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tmz1t_3413	COG2967	ApaG domain
Tmz1t_3414	COG3447	MASE1 domain protein
Tmz1t_3414	COG5002	protein histidine kinase activity
Tmz1t_3414	COG5001	Diguanylate cyclase
Tmz1t_3417	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tmz1t_3418	COG0653	protein targeting
Tmz1t_3421	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Tmz1t_3424	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tmz1t_3425	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tmz1t_3426	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tmz1t_3427	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tmz1t_3428	COG0772	Belongs to the SEDS family
Tmz1t_3429	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tmz1t_3430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tmz1t_3431	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tmz1t_3432	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tmz1t_3434	COG3116	cell division
Tmz1t_3435	COG0275	rRNA processing
Tmz1t_3436	COG2001	Belongs to the MraZ family
Tmz1t_3438	COG0418	dihydroorotase activity
Tmz1t_3440	COG0792	nuclease activity
Tmz1t_3441	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tmz1t_3443	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tmz1t_3445	COG0511	ligase activity, forming carbon-carbon bonds
Tmz1t_3446	COG0439	Biotin carboxylase
Tmz1t_3447	COG2264	protein methyltransferase activity
Tmz1t_3451	COG0537	adenosine 5'-monophosphoramidase activity
Tmz1t_3454	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tmz1t_3458	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tmz1t_3459	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tmz1t_3460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tmz1t_3462	COG3338	carbonate dehydratase activity
Tmz1t_3463	COG0351	phosphomethylpyrimidine kinase
Tmz1t_3464	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tmz1t_3465	COG1063	alcohol dehydrogenase
Tmz1t_3467	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmz1t_3469	COG4647	ligase activity
Tmz1t_3470	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
Tmz1t_3471	COG0145	ligase activity
Tmz1t_3472	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tmz1t_3473	COG2885	chlorophyll binding
Tmz1t_3474	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tmz1t_3475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tmz1t_3476	COG1566	PFAM secretion protein HlyD family protein
Tmz1t_3477	COG0577	efflux transmembrane transporter activity
Tmz1t_3477	COG1136	(ABC) transporter
Tmz1t_3478	COG1136	(ABC) transporter
Tmz1t_3478	COG0577	efflux transmembrane transporter activity
Tmz1t_3479	COG0577	efflux transmembrane transporter activity
Tmz1t_3479	COG1136	(ABC) transporter
Tmz1t_3480	COG1509	lysine 2,3-aminomutase activity
Tmz1t_3482	COG2321	neutral zinc metallopeptidase
Tmz1t_3483	COG0439	Biotin carboxylase
Tmz1t_3484	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tmz1t_3485	COG1703	isobutyryl-CoA mutase activity
Tmz1t_3486	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tmz1t_3486	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tmz1t_3487	COG1802	Transcriptional regulator
Tmz1t_3488	COG1253	flavin adenine dinucleotide binding
Tmz1t_3489	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tmz1t_3490	COG3162	membrane
Tmz1t_3491	COG1024	Enoyl-CoA hydratase
Tmz1t_3494	COG1136	(ABC) transporter
Tmz1t_3496	COG0735	belongs to the Fur family
Tmz1t_3498	COG1121	(ABC) transporter
Tmz1t_3499	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tmz1t_3500	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tmz1t_3501	COG1280	lysine exporter protein (LysE YggA)
Tmz1t_3503	COG2205	protein histidine kinase activity
Tmz1t_3504	COG0745	RESPONSE REGULATOR receiver
Tmz1t_3505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tmz1t_3506	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Tmz1t_3508	COG0129	dihydroxy-acid dehydratase activity
Tmz1t_3509	COG3132	Protein of unknown function, DUF480
Tmz1t_3510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tmz1t_3512	COG5001	Diguanylate cyclase
Tmz1t_3512	COG3300	MHYT domain
Tmz1t_3521	COG0735	belongs to the Fur family
Tmz1t_3522	COG1858	cytochrome C peroxidase
Tmz1t_3523	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmz1t_3524	COG0577	efflux transmembrane transporter activity
Tmz1t_3524	COG1136	(ABC) transporter
Tmz1t_3526	COG4774	siderophore transport
Tmz1t_3530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tmz1t_3533	COG0318	PFAM AMP-dependent synthetase and ligase
Tmz1t_3536	COG2119	membrane
Tmz1t_3541	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Tmz1t_3547	COG4608	Belongs to the ABC transporter superfamily
Tmz1t_3548	COG0444	Belongs to the ABC transporter superfamily
Tmz1t_3549	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tmz1t_3557	COG2226	methyltransferase
Tmz1t_3562	COG2814	Major facilitator Superfamily
Tmz1t_3565	COG1115	amino acid carrier protein
Tmz1t_3578	COG0477	Major facilitator Superfamily
Tmz1t_3582	COG1280	lysine exporter protein (LysE YggA)
Tmz1t_3585	COG0534	Mate efflux family protein
Tmz1t_3586	COG0259	pyridoxamine-phosphate oxidase activity
Tmz1t_3588	COG1139	Iron-sulfur cluster binding protein
Tmz1t_3589	COG0247	lactate metabolic process
Tmz1t_3591	COG1024	Enoyl-CoA hydratase
Tmz1t_3592	COG1944	ATP diphosphatase activity
Tmz1t_3596	COG3586	endonuclease activity
Tmz1t_3598	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tmz1t_3600	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tmz1t_3601	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Tmz1t_3605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tmz1t_3606	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tmz1t_3608	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tmz1t_3609	COG0405	Gamma-glutamyltransferase
Tmz1t_3610	COG3300	MHYT domain
Tmz1t_3610	COG5001	Diguanylate cyclase
Tmz1t_3611	COG1132	(ABC) transporter
Tmz1t_3612	COG3634	alkyl hydroperoxide reductase activity
Tmz1t_3615	COG2884	Cell division ATP-binding protein ftsE
Tmz1t_3617	COG0612	Peptidase, M16
Tmz1t_3618	COG0612	Peptidase, M16
Tmz1t_3619	COG0742	ribosomal rna small subunit methyltransferase
Tmz1t_3620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tmz1t_3621	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tmz1t_3622	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Tmz1t_3623	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tmz1t_3625	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Tmz1t_3626	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tmz1t_3627	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tmz1t_3628	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tmz1t_3629	COG0193	aminoacyl-tRNA hydrolase activity
Tmz1t_3631	COG0012	GTP binding
Tmz1t_3633	COG0242	peptide deformylase activity
Tmz1t_3637	COG0463	Glycosyl transferase, family 2
Tmz1t_3639	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tmz1t_3640	COG1832	CoA-binding protein
Tmz1t_3641	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Tmz1t_3642	COG3568	Endonuclease Exonuclease Phosphatase
Tmz1t_3645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tmz1t_3650	COG3852	Histidine kinase
Tmz1t_3653	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tmz1t_3654	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tmz1t_3656	COG0237	dephospho-CoA kinase activity
Tmz1t_3657	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Tmz1t_3658	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Tmz1t_3659	COG0352	thiamine-phosphate diphosphorylase activity
Tmz1t_3662	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Tmz1t_3663	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tmz1t_3664	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tmz1t_3665	COG0305	Participates in initiation and elongation during chromosome replication
Tmz1t_3666	COG0359	binds to the 23S rRNA
Tmz1t_3667	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tmz1t_3668	COG2965	DNA replication, synthesis of RNA primer
Tmz1t_3669	COG0360	Binds together with S18 to 16S ribosomal RNA
Tmz1t_3671	COG1643	Atp-dependent helicase
Tmz1t_3672	COG1618	nucleotide phosphatase activity, acting on free nucleotides
Tmz1t_3672	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Tmz1t_3674	COG1968	undecaprenyl-diphosphatase activity
Tmz1t_3675	COG3150	esterase
Tmz1t_3676	COG2226	methyltransferase
Tmz1t_3678	COG0557	exoribonuclease II activity
Tmz1t_3680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tmz1t_3681	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tmz1t_3682	COG2239	Acts as a magnesium transporter
Tmz1t_3683	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tmz1t_3685	COG0352	thiamine-phosphate diphosphorylase activity
Tmz1t_3686	COG0351	phosphomethylpyrimidine kinase
Tmz1t_3687	COG1773	rubredoxin
Tmz1t_3690	COG0835	chemotaxis
Tmz1t_3691	COG0840	transmembrane signaling receptor activity
Tmz1t_3692	COG0643	Histidine kinase
Tmz1t_3692	COG2198	Histidine kinase
Tmz1t_3693	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Tmz1t_3694	COG0415	Belongs to the DNA photolyase family
Tmz1t_3695	COG1678	Uncharacterized ACR, COG1678
Tmz1t_3696	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tmz1t_3697	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tmz1t_3698	COG0540	Belongs to the ATCase OTCase family
Tmz1t_3708	COG0437	4 iron, 4 sulfur cluster binding
Tmz1t_3709	COG3383	formate dehydrogenase (NAD+) activity
Tmz1t_3709	COG0243	molybdopterin cofactor binding
Tmz1t_3715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tmz1t_3716	COG0746	molybdenum cofactor guanylyltransferase activity
Tmz1t_3718	COG1252	NADH dehydrogenase
Tmz1t_3719	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tmz1t_3720	COG3852	Histidine kinase
Tmz1t_3721	COG2204	response regulator
Tmz1t_3725	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Tmz1t_3726	COG5002	protein histidine kinase activity
Tmz1t_3728	COG4654	Cytochrome c, class I
Tmz1t_3729	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tmz1t_3729	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tmz1t_3730	COG1492	cobalamin metabolic process
Tmz1t_3733	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tmz1t_3740	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Tmz1t_3745	COG0427	acetyl-CoA hydrolase
Tmz1t_3746	COG0516	GMP reductase activity
Tmz1t_3746	COG0517	IMP dehydrogenase activity
Tmz1t_3747	COG0688	phosphatidylethanolamine metabolic process
Tmz1t_3751	COG1648	precorrin-2 dehydrogenase activity
Tmz1t_3751	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tmz1t_3755	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Tmz1t_3756	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tmz1t_3757	COG4206	TonB-dependent receptor
Tmz1t_3759	COG4636	protein conserved in cyanobacteria
Tmz1t_3760	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tmz1t_3761	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Tmz1t_3763	COG2831	hemolysin activation secretion protein
Tmz1t_3764	COG0406	alpha-ribazole phosphatase activity
Tmz1t_3773	COG1215	transferase activity, transferring glycosyl groups
Tmz1t_3778	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Tmz1t_3780	COG1215	transferase activity, transferring glycosyl groups
Tmz1t_3781	COG5433	transposase activity
Tmz1t_3784	COG2171	N-acyltransferase activity
Tmz1t_3785	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Tmz1t_3793	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tmz1t_3794	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tmz1t_3795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tmz1t_3804	COG0438	transferase activity, transferring glycosyl groups
Tmz1t_3805	COG5433	transposase activity
Tmz1t_3807	COG4636	protein conserved in cyanobacteria
Tmz1t_3808	COG4636	protein conserved in cyanobacteria
Tmz1t_3810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Tmz1t_3812	COG1132	(ABC) transporter
Tmz1t_3813	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tmz1t_3813	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tmz1t_3817	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Tmz1t_3820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tmz1t_3821	COG0799	negative regulation of ribosome biogenesis
Tmz1t_3822	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Tmz1t_3823	COG0424	maF-like protein
Tmz1t_3824	COG1530	ribonuclease E activity
Tmz1t_3825	COG4636	protein conserved in cyanobacteria
Tmz1t_3826	COG0410	ABC transporter
Tmz1t_3829	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tmz1t_3831	COG0632	four-way junction helicase activity
Tmz1t_3832	COG2255	four-way junction helicase activity
Tmz1t_3835	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Tmz1t_3837	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tmz1t_3838	COG1560	Kdo2-lipid A biosynthetic process
Tmz1t_3840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tmz1t_3842	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tmz1t_3843	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tmz1t_3845	COG4206	TonB-dependent receptor
Tmz1t_3847	COG5002	protein histidine kinase activity
Tmz1t_3847	COG0784	Response regulator, receiver
Tmz1t_3847	COG2205	protein histidine kinase activity
Tmz1t_3850	COG4206	TonB-dependent receptor
Tmz1t_3851	COG0745	RESPONSE REGULATOR receiver
Tmz1t_3851	COG3706	GGDEF domain
Tmz1t_3852	COG0433	COG0433 Predicted ATPase
Tmz1t_3853	COG0217	transcriptional regulatory protein
Tmz1t_3855	COG0393	Putative heavy-metal-binding
Tmz1t_3856	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tmz1t_3858	COG3093	addiction module antidote protein HigA
Tmz1t_3860	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
Tmz1t_3866	COG4566	intracellular signal transduction
Tmz1t_3868	COG0745	RESPONSE REGULATOR receiver
Tmz1t_3869	COG4191	Histidine kinase
Tmz1t_3876	COG2308	Evidence 4 Homologs of previously reported genes of
Tmz1t_3883	COG0625	glutathione transferase activity
Tmz1t_3885	COG2161	toxin-antitoxin pair type II binding
Tmz1t_3893	COG4115	mRNA cleavage
Tmz1t_3894	COG2161	toxin-antitoxin pair type II binding
Tmz1t_3900	COG1132	(ABC) transporter
Tmz1t_3904	COG0438	transferase activity, transferring glycosyl groups
Tmz1t_3912	COG4636	protein conserved in cyanobacteria
Tmz1t_3915	COG4232	protein-disulfide reductase activity
Tmz1t_3918	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tmz1t_3919	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tmz1t_3921	COG0375	protein maturation
Tmz1t_3923	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tmz1t_3924	COG0298	carbon dioxide binding
Tmz1t_3925	COG0409	Hydrogenase expression formation protein
Tmz1t_3926	COG0309	Hydrogenase expression formation protein (HypE)
Tmz1t_3929	COG0765	amino acid transport
Tmz1t_3930	COG1126	abc transporter atp-binding protein
Tmz1t_3936	COG0829	nickel cation binding
Tmz1t_3937	COG0831	urea catabolic process
Tmz1t_3938	COG0832	Belongs to the urease beta subunit family
Tmz1t_3939	COG0804	urea catabolic process
Tmz1t_3940	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Tmz1t_3941	COG0830	nickel cation binding
Tmz1t_3942	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Tmz1t_3945	COG1335	isochorismatase
Tmz1t_3946	COG1012	belongs to the aldehyde dehydrogenase family
Tmz1t_3948	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tmz1t_3950	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
Tmz1t_3951	COG0415	Belongs to the DNA photolyase family
Tmz1t_3953	COG0415	Belongs to the DNA photolyase family
Tmz1t_3956	COG0322	excinuclease ABC activity
Tmz1t_3958	COG0438	transferase activity, transferring glycosyl groups
Tmz1t_3976	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tmz1t_3977	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmz1t_3981	COG2132	Multicopper oxidase
Tmz1t_3986	COG5002	protein histidine kinase activity
Tmz1t_3994	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tmz1t_3995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tmz1t_3998	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tmz1t_4000	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Tmz1t_4003	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tmz1t_4004	COG4133	protoheme IX ABC transporter activity
Tmz1t_4005	COG3005	denitrification pathway
Tmz1t_4007	COG0348	domain, Protein
Tmz1t_4008	COG0437	4 iron, 4 sulfur cluster binding
Tmz1t_4009	COG0243	molybdopterin cofactor binding
Tmz1t_4012	COG2197	response regulator
Tmz1t_4013	COG3850	Histidine kinase
Tmz1t_4017	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tmz1t_4018	COG1758	RNA polymerase activity
Tmz1t_4019	COG0194	GDP metabolic process
Tmz1t_4021	COG1561	YicC-like family, N-terminal region
Tmz1t_4022	COG0515	serine threonine protein kinase
Tmz1t_4023	COG0631	protein serine/threonine phosphatase activity
Tmz1t_4024	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tmz1t_4025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tmz1t_4026	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tmz1t_4030	COG2814	Major facilitator Superfamily
Tmz1t_4031	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tmz1t_4034	COG1021	2,3-dihydroxybenzoate-AMP ligase
Tmz1t_4040	COG4584	PFAM Integrase catalytic
Tmz1t_4043	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tmz1t_4043	COG1902	pentaerythritol trinitrate reductase activity
Tmz1t_4046	COG1012	belongs to the aldehyde dehydrogenase family
Tmz1t_4049	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tmz1t_4050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmz1t_4053	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Tmz1t_4056	COG2205	protein histidine kinase activity
Tmz1t_4061	COG1881	PFAM PEBP family protein
Tmz1t_4062	COG0616	signal peptide processing
Tmz1t_4063	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Tmz1t_4064	COG2022	thiamine diphosphate biosynthetic process
Tmz1t_4066	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tmz1t_4067	COG2813	Specifically methylates the guanine in position
Tmz1t_4067	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tmz1t_4070	COG2223	nitrite transmembrane transporter activity
Tmz1t_4075	COG0656	L-ascorbic acid biosynthetic process
Tmz1t_4077	COG0288	reversible hydration of carbon dioxide
Tmz1t_4078	COG1940	carbohydrate kinase activity
Tmz1t_4079	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tmz1t_4080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tmz1t_4082	COG0569	domain protein
Tmz1t_4083	COG2204	response regulator
Tmz1t_4084	COG5000	phosphorelay sensor kinase activity
Tmz1t_4087	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tmz1t_4089	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34