locus-tag class description Tph_c00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Tph_c00030 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Tph_c00050 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tph_c00130 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tph_c00140 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) Tph_c00150 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Tph_c00180 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Tph_c00260 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Tph_c00270 ENOG4107R4E Membrane Tph_c00290 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Tph_c00300 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Tph_c00310 ENOG4105FA0 parb-like partition protein Tph_c00330 ENOG4107QJE Chromosome Partitioning Protein Tph_c00340 ENOG4105FA0 parb-like partition protein Tph_c00360 ENOG4105C8M UPF0272 protein Tph_c00370 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase Tph_c00390 ENOG4105DR5 peptidase Tph_c00410 ENOG4106AUC UPF0180 protein Tph_c00420 ENOG4108ZDA Sporulation protein YyaC Tph_c00430 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) Tph_c00440 ENOG4105EM7 Selenocysteine-specific translation elongation factor Tph_c00450 ENOG4105CP9 extracellular ligand-binding receptor Tph_c00460 ENOG4105C32 Amino acid ABC transporter (Permease) Tph_c00470 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Tph_c00480 ENOG4105C0Z ABC transporter Tph_c00490 ENOG4108IV0 ABC, transporter Tph_c00500 ENOG4105W87 Cbs domain Tph_c00520 ENOG4107EFR Flavocytochrome c Tph_c00540 ENOG4107YHD transcriptional regulator Tph_c00590 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) Tph_c00600 ENOG4105DJZ UPF0182 protein Tph_c00610 ENOG41069DP small acid-soluble spore protein Tph_c00670 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) Tph_c00680 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) Tph_c00700 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Tph_c00710 ENOG4108UUM single-stranded DNA-binding protein Tph_c00720 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Tph_c00760 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin Tph_c00770 ENOG4105BZR domain protein Tph_c00780 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Tph_c00790 ENOG4108IUQ atp-dependent protease Tph_c00800 ENOG4105CDU Replicative dna helicase Tph_c00850 ENOG4108IG5 Transcriptional regulator Tph_c00890 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Tph_c00940 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Tph_c01050 ENOG41080XS Cobyrinic acid ac-diamide synthase Tph_c01070 ENOG4105EHG Permease protein Tph_c01080 ENOG4105E0A ABC, transporter Tph_c01110 ENOG4107VHA regulatoR Tph_c01120 ENOG4105CRE cytochrome C Tph_c01130 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) Tph_c01140 ENOG4107YHD transcriptional regulator Tph_c01160 ENOG4107EFR Flavocytochrome c Tph_c01170 ENOG4107EFR Flavocytochrome c Tph_c01180 ENOG4107EFR Flavocytochrome c Tph_c01190 ENOG4105EHG Permease protein Tph_c01200 ENOG4105E0A ABC, transporter Tph_c01210 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Tph_c01230 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Tph_c01290 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Tph_c01320 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein Tph_c01450 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tph_c01480 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Tph_c01490 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b Tph_c01500 ENOG4105CVM Molybdenum cofactor synthesis domain protein Tph_c01510 ENOG4105CVM Molybdenum cofactor synthesis domain protein Tph_c01550 ENOG4105EHG Permease protein Tph_c01560 ENOG4105E0A ABC, transporter Tph_c01570 ENOG4105S10 periplasmic binding protein Tph_c01580 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tph_c01600 ENOG4107XNE ABC transporter, periplasmic molybdate-binding protein Tph_c01610 ENOG4108I5D sulfate abc transporter Tph_c01620 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Tph_c01630 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tph_c01650 ENOG4108RIR Molybdenum cofactor biosynthesis protein Tph_c01670 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Tph_c01720 ENOG4105QAX Iron-sulfur Tph_c01740 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Tph_c01750 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Tph_c01760 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b Tph_c01770 ENOG4105CVM Molybdenum cofactor synthesis domain protein Tph_c01790 ENOG4105FDP GntR family transcriptional regulator Tph_c01800 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c01810 ENOG4107VP5 methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase Tph_c01870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tph_c01900 ENOG4105EQI Metal Dependent Phosphohydrolase Tph_c01910 ENOG4105G9B Transcriptional regulator Tph_c01960 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin Tph_c02000 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Tph_c02100 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Tph_c02230 ENOG4105CN9 Peptidase m42 family protein Tph_c02240 ENOG4105DJY efflux transporter, rnd family, mfp subunit Tph_c02260 ENOG4105XEA Tetr family transcriptional regulator Tph_c02310 ENOG4105ESV Glycosyl transferase, family 4 Tph_c02420 ENOG4105BZU Histidine kinase Tph_c02430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tph_c02530 ENOG4105C1J atp-dependent rna helicase Tph_c02580 ENOG4108RB3 Capsular polysaccharide biosynthesis protein Tph_c02620 ENOG4107GBW cellulosome anchoring protein cohesin Tph_c02640 ENOG4105HTX biosynthesis protein Tph_c02650 ENOG4108QV3 biosynthesis protein Tph_c02670 ENOG4105ESV Glycosyl transferase, family 4 Tph_c02690 ENOG4105C6Y Udp-glucose 6-dehydrogenase Tph_c02730 ENOG4105CG5 Glycosyl transferase (Group 1 Tph_c02780 ENOG4105CPK Glycosyl transferase (Group 1 Tph_c02810 ENOG4108PQP glycosyl transferase group 1 Tph_c02930 ENOG4108N3W hemolysin secretion protein Tph_c03090 ENOG4105BZU Histidine kinase Tph_c03240 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Tph_c03310 ENOG4105UQX Mate efflux family protein Tph_c03330 ENOG4105DCI Phosphohydrolase Tph_c03390 ENOG4105EET magnesium chelatase Tph_c03420 ENOG4105EHG Permease protein Tph_c03430 ENOG4105E0A ABC, transporter Tph_c03440 ENOG4105CTK cobaltochelatase, cobn subunit Tph_c03490 ENOG4105CJ1 ABC, transporter Tph_c03520 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein Tph_c03540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tph_c03560 ENOG4108JQ7 (ABC) transporter Tph_c03570 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tph_c03600 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c03610 ENOG4105C3R Methionine synthase Tph_c03620 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c03630 ENOG4105ECQ AraC Family Transcriptional Regulator Tph_c03640 ENOG4105C1B dTDP-glucose 4-6-dehydratase Tph_c03660 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Tph_c03710 ENOG41066A3 ATP guanido phosphotransferase Tph_c03720 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tph_c03740 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase Tph_c03750 ENOG4106DSS Tartrate dehydratase subunit alpha Tph_c03790 ENOG4107EFR Flavocytochrome c Tph_c03800 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tph_c03810 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Tph_c03820 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) Tph_c03840 ENOG4108VJ1 Transcriptional regulator (CarD family Tph_c03850 ENOG4105CTP PilT protein domain protein Tph_c03860 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Tph_c03880 ENOG4108JUB Transcriptional regulator Tph_c03920 ENOG4105D0M Protease HtpX homolog Tph_c03940 ENOG4105D07 Signal peptide peptidase, SppA Tph_c04000 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Tph_c04010 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Tph_c04040 ENOG4107QI1 Mate efflux family protein Tph_c04100 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Tph_c04110 ENOG4106HK8 GPR1 FUN34 yaaH family protein Tph_c04120 ENOG4108U5N UPF0316 protein Tph_c04130 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Tph_c04150 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Tph_c04170 ENOG4108RC0 Electron transport protein Tph_c04180 ENOG4105WE2 aldehyde ferredoxin oxidoreductase Tph_c04200 ENOG4105GKE subunit e Tph_c04210 ENOG4107QIZ NADH dehydrogenase Tph_c04360 ENOG4108JJB ABC transporter Tph_c04440 ENOG4105CMQ Chloride channel Tph_c04450 ENOG41089UC methyltransferase, type 11 Tph_c04490 ENOG4105EQN UPF0261 protein Tph_c04500 ENOG4108N5B 2-phosphosulfolactate phosphatase Tph_c04520 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate Tph_c04560 ENOG4105CE1 Ferrous iron transport protein b Tph_c04600 ENOG4105FKZ Methyl-accepting chemotaxis Tph_c04630 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Tph_c04640 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tph_c04650 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Tph_c04660 ENOG4108IUQ atp-dependent protease Tph_c04670 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Tph_c04740 ENOG4107HP6 Transcriptional regulator Tph_c04760 ENOG4105CK7 Sodium proline symporter Tph_c04780 ENOG4105CKM Branched-chain carboxylic acid kinase Tph_c04790 ENOG4107RE7 phosphate butyryltransferase Tph_c04830 ENOG4105CVA phosphate Tph_c04840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Tph_c04850 ENOG4105BZU Histidine kinase Tph_c04860 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Tph_c04870 ENOG4108UTW Plays a role in the regulation of phosphate uptake Tph_c04880 ENOG4105C8U phosphate abc transporter Tph_c04890 ENOG4105E2Z phosphate ABC transporter (Permease Tph_c04910 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Tph_c04920 ENOG4105D7W serine acetyltransferase Tph_c04930 ENOG4105C8N cysteinyl-tRNA synthetase Tph_c04950 ENOG4105C2N RNA methyltransferase TrmH family group 3 Tph_c04960 ENOG4105M0M Tetracycline resistance protein Tph_c04970 ENOG4105QIV RNA polymerase Tph_c05040 ENOG4105YFD chemotaxis, protein Tph_c05050 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Tph_c05070 ENOG4105BZU Histidine kinase Tph_c05080 ENOG4105EEX Two component transcriptional regulator (Winged helix family Tph_c05090 ENOG4105CBS Chea signal transduction histidine kinase Tph_c05110 ENOG4105C8Q Methyl-accepting chemotaxis Tph_c05130 ENOG4105C8Q Methyl-accepting chemotaxis Tph_c05140 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Tph_c05150 ENOG4105JZC GHMP kinase Tph_c05160 ENOG4105CIH Imidazole acetol-phosphate transaminase Tph_c05180 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Tph_c05190 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Tph_c05210 ENOG4108JJB ABC transporter Tph_c05220 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) Tph_c05230 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase Tph_c05240 ENOG4105DVK Precorrin-2 c20-methyltransferase Tph_c05250 ENOG4105CIA precorrin-4 C(11)-methyltransferase Tph_c05260 ENOG4108P62 biosynthesis protein (CbiG) Tph_c05270 ENOG4105E4R Precorrin-3B C17-methyltransferase Tph_c05290 ENOG41081F0 Precorrin-8x methylmutase Tph_c05300 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Tph_c05320 ENOG4107NFR Fructose-1,6-bisphosphatase Tph_c05330 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Tph_c05340 ENOG4106VK6 Flagellar motor protein Tph_c05350 ENOG4105E14 MotA TolQ exbB proton channel Tph_c05390 ENOG4108QY0 Membrane Tph_c05490 ENOG4105WH1 Two component transcriptional regulator luxr family Tph_c05550 ENOG41081UC Inherit from COG: Competence protein Tph_c05590 ENOG4105ETS cytosine purines uracil thiamine allantoin Tph_c05600 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Tph_c05670 ENOG4105E1Q flagellar hook-associated protein Tph_c05700 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) Tph_c05710 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Tph_c05720 ENOG4108XIB electron transport protein ysaA Tph_c05730 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit Tph_c05740 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) Tph_c05760 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit Tph_c05770 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Tph_c05790 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Tph_c05800 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Tph_c05830 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Tph_c05840 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Tph_c05850 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tph_c05860 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c05920 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Tph_c05930 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) Tph_c05950 ENOG4108Z03 MAF-like protein Tph_c05960 ENOG4105W5Q DNA repair protein (RadC Tph_c05970 ENOG4105DFF Rod shape-determining protein mreb Tph_c05980 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) Tph_c06000 ENOG4107RF6 penicillin-binding protein Tph_c06010 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Tph_c06020 ENOG4107QMS site-determining protein Tph_c06030 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) Tph_c06040 ENOG4105CNI cell division protein FtsW Tph_c06080 ENOG4105C03 ribonuclease Tph_c06090 ENOG4105CPN adenine deaminase Tph_c06130 ENOG4105K8R UPF0145 protein Tph_c06170 ENOG4105EMN RNA polymerase sigma factor Tph_c06330 ENOG4105E5H Transposase Tph_c06350 ENOG4105E3S small subunit Tph_c06360 ENOG4105DPX Hydrogenase, large subunit Tph_c06390 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase Tph_c06400 ENOG4105VYW UPF0251 protein Tph_c06460 ENOG4105MS2 ribosomal subunit Interface protein Tph_c06470 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Tph_c06490 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Tph_c06510 ENOG4108HHA Transketolase Tph_c06520 ENOG4108IUS Transketolase Tph_c06530 ENOG4105CAK Cell division ATP-binding protein ftsE Tph_c06540 ENOG4105CRP Part of the ABC transporter FtsEX involved in Tph_c06550 ENOG4105DR5 peptidase Tph_c06630 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Tph_c06640 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Tph_c06650 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Tph_c06660 ENOG410667J hydrolase Tph_c06670 ENOG4107QYV phosphohexose isomerase Tph_c06680 ENOG4105DKQ ROK family Tph_c06690 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Tph_c06700 ENOG4105CHW UPF0052 protein Tph_c06710 ENOG4105CIE May be required for sporulation (By similarity) Tph_c06730 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tph_c06750 ENOG4105BZA Phosphoglycerate kinase Tph_c06760 ENOG4105CP7 Triose-phosphate isomerase Tph_c06770 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Tph_c06780 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Tph_c06790 ENOG4105XZU Preprotein translocase, subunit SecG Tph_c06820 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c06830 ENOG4108KN0 Choline kinase Tph_c06870 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place Tph_c06930 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase Tph_c06940 ENOG4105CPD ethanolamine ammonia-lyase Tph_c06950 ENOG4107FQ9 ethanolamine ammonia-lyase Tph_c06960 ENOG4106D67 ethanolamine utilization protein Tph_c06970 ENOG4108EKI Dehydrogenase Tph_c06980 ENOG4105KNY Microcompartments protein Tph_c06990 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase Tph_c07000 ENOG4107RWI ethanolamine utilization protein eutJ Tph_c07030 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Tph_c07040 ENOG4105KNY Microcompartments protein Tph_c07060 ENOG4105KNY Microcompartments protein Tph_c07070 ENOG4105ENY Ethanolamine utilization protein eutH Tph_c07130 ENOG4107T2D Phosphoribosylaminoimidazolesuccinocarboxamide synthase Tph_c07140 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Tph_c07150 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Tph_c07230 ENOG4107GBW cellulosome anchoring protein cohesin Tph_c07250 ENOG4105K4W Could be involved in septation (By similarity) Tph_c07290 ENOG4106A3R peptidase Tph_c07410 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tph_c07520 ENOG4105DR5 peptidase Tph_c07660 ENOG4105MAX Superoxide reductase Tph_c07720 ENOG4105DQ6 Transposase Tph_c07780 ENOG4105BZU Histidine kinase Tph_c07850 ENOG4107Y5K Resolvase Tph_c07980 ENOG4105VXP Protein of unknown function DUF86 Tph_c07990 ENOG4105VCQ rubredoxin Tph_c08000 ENOG4105MAX Superoxide reductase Tph_c08020 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Tph_c08030 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Tph_c08050 ENOG4107QIZ NADH dehydrogenase Tph_c08080 ENOG4105DQE DNA ligase Tph_c08100 ENOG4105VRS hydrolase family 18 Tph_c08130 ENOG4108KGH TRANSCRIPTIONal Tph_c08140 ENOG410688J Ferredoxin Tph_c08160 ENOG4107EF8 Glycosyl transferase (Group 1 Tph_c08170 ENOG4105E4C Lytic transglycosylase catalytic Tph_c08180 ENOG4105D06 uba thif-type nad fad binding protein Tph_c08190 ENOG4105BZU Histidine kinase Tph_c08200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Tph_c08210 ENOG4108RC0 Electron transport protein Tph_c08220 ENOG4105WE2 aldehyde ferredoxin oxidoreductase Tph_c08240 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit Tph_c08250 ENOG4107QIZ NADH dehydrogenase Tph_c08260 ENOG4107QHI -hydrogenase Tph_c08280 ENOG4105CKU formyltetrahydrofolate synthetase Tph_c08290 ENOG4105DVM PP-loop domain protein Tph_c08310 ENOG4105CVM Molybdenum cofactor synthesis domain protein Tph_c08320 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family Tph_c08330 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tph_c08340 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tph_c08360 ENOG4108RIR Molybdenum cofactor biosynthesis protein Tph_c08370 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Tph_c08390 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Tph_c08400 ENOG4108UGV hypoxanthine phosphoribosyltransferase Tph_c08410 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Tph_c08420 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Tph_c08430 ENOG4105C83 adenylosuccinate lyase Tph_c08450 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Tph_c08460 ENOG4107QIK phosphoribosylformylglycinamidine synthase Tph_c08470 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase Tph_c08480 ENOG4105CXB phosphoribosylaminoimidazole synthetase Tph_c08490 ENOG4108V3E phosphoribosylglycinamide formyltransferase Tph_c08500 ENOG4105DC1 bifunctional purine biosynthesis protein purh Tph_c08510 ENOG4105C12 Phosphoribosylglycinamide synthetase Tph_c08550 ENOG4105EYU Glutamine amido-transferase Tph_c08560 ENOG4105CBC glutamate synthase Tph_c08570 ENOG4105BZ8 glutamate synthase Tph_c08600 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Tph_c08610 ENOG4105C4K Nad synthetase Tph_c08620 ENOG4105C5F glutamine synthetase Tph_c08630 ENOG4105CAQ asparagine synthetase Tph_c08650 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Tph_c08660 ENOG4108YZA Nitrogen regulatory protein pii Tph_c08670 ENOG4108YZA Nitrogen regulatory protein pii Tph_c08680 ENOG4105D0B Nitrogenase protein alpha chain Tph_c08690 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain Tph_c08700 ENOG4105D0B Nitrogenase protein alpha chain Tph_c08720 ENOG4107S73 homocitrate synthase Tph_c08730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Tph_c08760 ENOG4108YZA Nitrogen regulatory protein pii Tph_c08770 ENOG4105E1K spore germination protein Tph_c08790 ENOG4108NHD germination protein Tph_c08810 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) Tph_c08820 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Tph_c08830 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Tph_c08840 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Tph_c08850 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Tph_c08860 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Tph_c08870 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Tph_c08880 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Tph_c08910 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Tph_c08930 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Tph_c08940 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tph_c08960 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Tph_c08970 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Tph_c08980 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Tph_c09000 ENOG4107SDT Homocitrate synthase Tph_c09010 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tph_c09020 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tph_c09030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Tph_c09040 ENOG4108NHD germination protein Tph_c09060 ENOG4105E1K spore germination protein Tph_c09100 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Tph_c09120 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c09130 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) Tph_c09140 ENOG410847I Transcriptional regulator, BadM Rrf2 family Tph_c09150 ENOG4107RFW hydrolase family 57 Tph_c09200 ENOG4105CQS hydrogenase expression formation protein HypD Tph_c09210 ENOG4105C45 hydrogenase expression formation protein (HypE) Tph_c09230 ENOG4105CD3 dihydroorotase Tph_c09270 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Tph_c09300 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Tph_c09310 ENOG4108K9K Uncharacterised protein family (UPF0236) Tph_c09340 ENOG4105C0B DNA polymerase III (alpha subunit) Tph_c09350 ENOG4105WP2 Tryptophan RNA-binding attenuator protein Tph_c09380 ENOG4105CTQ phosphohexokinase Tph_c09410 ENOG4105DIW FeS assembly protein SUFB Tph_c09470 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein Tph_c09500 ENOG4105DUM transcriptional regulator, lysR family Tph_c09510 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Tph_c09560 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Tph_c09570 ENOG4107XM9 (LipO)protein Tph_c09600 ENOG4105C6N Formate acetyltransferase Tph_c09680 ENOG4105C5F glutamine synthetase Tph_c09690 ENOG4105C8Q Methyl-accepting chemotaxis Tph_c09770 ENOG41084CE UPF0342 protein Tph_c09780 ENOG4108YZP cobalt ABC transporter, inner membrane subunit CbiQ Tph_c09790 ENOG4108JJB ABC transporter Tph_c09810 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Tph_c09820 ENOG4105CYW agmatinase Tph_c09950 ENOG4105C22 threonyL-tRNA synthetase Tph_c09960 ENOG4108ZAA Alkaline-shock protein Tph_c09980 ENOG4105CB5 ATP-dependent DNA helicase recG Tph_c10010 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) Tph_c10020 ENOG4108UN4 phage SPO1 DNA polymerase-related protein Tph_c10030 ENOG4108K9K Uncharacterised protein family (UPF0236) Tph_c10040 ENOG4106H78 methyltransferase Tph_c10050 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Tph_c10070 ENOG4105H20 Sporulation integral membrane protein YlbJ Tph_c10080 ENOG4108IJ2 phosphate acetyltransferase Tph_c10090 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Tph_c10110 ENOG41067VY 50S ribosomal protein L32 Tph_c10120 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Tph_c10130 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Tph_c10140 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Tph_c10150 ENOG4105MCT stage V sporulation protein S Tph_c10160 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Tph_c10170 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Tph_c10180 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) Tph_c10190 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Tph_c10200 ENOG4107W7X Aldolase Tph_c10210 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Tph_c10230 ENOG4105K5M 30s ribosomal protein S16 Tph_c10250 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Tph_c10260 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Tph_c10270 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Tph_c10290 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) Tph_c10300 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Tph_c10320 ENOG4105VM1 flagellar Tph_c10330 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tph_c10340 ENOG41082RQ UPF0102 protein Tph_c10350 ENOG4105CQB FAD linked oxidase domain protein Tph_c10360 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Tph_c10400 ENOG4105C0P Mg chelatase subunit ChlI Tph_c10410 ENOG4105EAC phosphoserine phosphatase Tph_c10450 ENOG4105EKQ RNA-directed DNA polymerase Tph_c10530 ENOG4108XNA Gas vesicle Tph_c10540 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) Tph_c10590 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Tph_c10610 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) Tph_c10670 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Tph_c10680 ENOG4105DVE abc transporter atp-binding protein Tph_c10700 ENOG4105FDF Could be involved in DNA repair (By similarity) Tph_c10710 ENOG4105C79 DNA protecting protein DprA Tph_c10720 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Tph_c10730 ENOG4108FW6 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) Tph_c10740 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tph_c10750 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Tph_c10760 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Tph_c10790 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Tph_c10800 ENOG4108ZC9 flagellar basal-body rod protein flgc Tph_c10810 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Tph_c10820 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Tph_c10830 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Tph_c10890 ENOG410822I Flagellar hook capping protein Tph_c10910 ENOG4105BZE flagellar hook protein, FlgE Tph_c10940 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Tph_c10950 ENOG4105DD5 Flagellar motor switch protein Tph_c10960 ENOG4107YTP response regulator receiver protein Tph_c10980 ENOG4105CN7 Flagellar biosynthetic protein FliP Tph_c10990 ENOG4105VS8 Flagellar biosynthetic protein fliq Tph_c11000 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Tph_c11010 ENOG4105D00 flagellar biosynthetic protein flhB Tph_c11020 ENOG4105D7B Flagellar biosynthesis protein flha Tph_c11030 ENOG4105FZW flagellar biosynthesis regulator FlhF Tph_c11060 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Tph_c11070 ENOG4105CBS Chea signal transduction histidine kinase Tph_c11080 ENOG4107PHP CheC --inhibitor of MCP methylation Tph_c11090 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Tph_c11100 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tph_c11140 ENOG4105CE9 30S ribosomal protein S2 Tph_c11150 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Tph_c11160 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Tph_c11170 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Tph_c11210 ENOG4105KNE Phosphatidate cytidylyltransferase Tph_c11220 ENOG4108REF Sporulation integral membrane protein ytvi Tph_c11230 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Tph_c11240 ENOG4105DZP Membrane-associated zinc metalloprotease Tph_c11250 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Tph_c11260 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Tph_c11270 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Tph_c11280 ENOG4105CHV Transcription elongation factor NusA Tph_c11290 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination Tph_c11310 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Tph_c11310 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Tph_c11320 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Tph_c11330 ENOG4105SFS phosphoesterase RecJ domain protein Tph_c11340 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Tph_c11350 ENOG4105DTN riboflavin biosynthesis protein ribF Tph_c11360 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Tph_c11370 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Tph_c11400 ENOG4105C1V Peptidase, M16 Tph_c11430 ENOG4105E35 Dipicolinate synthase subunit A Tph_c11440 ENOG4108S0H Dipicolinic acid synthetase, b subunit Tph_c11450 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Tph_c11460 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Tph_c11470 ENOG4105CN5 Metallo-Beta-Lactamase Tph_c11490 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit Tph_c11500 ENOG4105CNU cell division protein FtsK Tph_c11510 ENOG4105DD7 kinase (PfkB family Tph_c11530 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Tph_c11560 ENOG4105CEV competence damage-inducible protein Tph_c11580 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Tph_c11590 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Tph_c11610 ENOG4105D48 metallophosphoesterase Tph_c11620 ENOG4105MCT stage V sporulation protein S Tph_c11630 ENOG4108IGT Dipeptidase Tph_c11650 ENOG4105K4H Nlp p60 protein Tph_c11690 ENOG4108YZT Adenosylcobinamide kinase Tph_c11700 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Tph_c11710 ENOG4105CVJ phosphoglycerate mutase Tph_c11720 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Tph_c11730 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tph_c11750 ENOG4105KT7 mgtC SapB transporter Tph_c11760 ENOG4105EKQ RNA-directed DNA polymerase Tph_c11790 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Tph_c11800 ENOG4105BZ4 penicillin-binding protein Tph_c12040 ENOG4105C0D helicase Tph_c12210 ENOG4107QJE Chromosome Partitioning Protein Tph_c12240 ENOG410836F Transposase Tph_c12270 ENOG4105CJ1 ABC, transporter Tph_c12290 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Tph_c12300 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Tph_c12320 ENOG4105WPN DNA integration recombination invertion protein Tph_c12330 ENOG41061AI Protein of unknown function (DUF2905) Tph_c12350 ENOG4105JFG SpoIID LytB domain protein Tph_c12370 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Tph_c12390 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) Tph_c12410 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Tph_c12420 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Tph_c12430 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Tph_c12460 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Tph_c12470 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) Tph_c12480 ENOG4105C5X domain protein Tph_c12490 ENOG4105CUT histidyl-tRNA synthetase Tph_c12500 ENOG4105C9M aspartyl-trna synthetase Tph_c12510 ENOG4105DZS Phenylacetate-CoA ligase Tph_c12530 ENOG4107VAM peptidase, m28 Tph_c12550 ENOG4108V6E Cell division protein mraZ Tph_c12560 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Tph_c12580 ENOG4105CJN penicillin-binding protein Tph_c12590 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Tph_c12600 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Tph_c12610 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Tph_c12620 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Tph_c12630 ENOG4105CNI cell division protein FtsW Tph_c12640 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Tph_c12650 ENOG4105DFU Cell wall formation (By similarity) Tph_c12660 ENOG4105D4A Cell wall formation (By similarity) Tph_c12670 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Tph_c12680 ENOG410812A polypeptide-transport-associated domain protein, FtsQ-type Tph_c12690 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Tph_c12700 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Tph_c12710 ENOG4108AWX Sporulation factor SpoIIGA Tph_c12720 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tph_c12730 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tph_c12740 ENOG4108ZXQ stage ii sporulation protein r Tph_c12750 ENOG4105WR5 sporulation protein, YlmC YmxH family Tph_c12760 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Tph_c12770 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase Tph_c12780 ENOG4105CEC DNA methylase N-4 N-6 Tph_c12810 ENOG410681U heavy metal transport detoxification protein Tph_c12830 ENOG4105DFA alanine racemase domain protein Tph_c12840 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Tph_c12860 ENOG4108VIA integral membrane protein Tph_c12870 ENOG4105VZ9 UPF0235 protein Tph_c12900 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Tph_c12910 ENOG4105VUC UPF0237 protein Tph_c12920 ENOG4105CAG UPF0210 protein Tph_c12950 ENOG4105BZF Glycosyl transferase (Group 1 Tph_c12960 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Tph_c12970 ENOG4105C34 Pseudouridine synthase Tph_c12980 ENOG4105C5F glutamine synthetase Tph_c13030 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Tph_c13040 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Tph_c13050 ENOG4105KXX peptidase s58 dmpa Tph_c13150 ENOG4105CPF Cell wall formation (By similarity) Tph_c13180 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Tph_c13230 ENOG4105DYS nad(p)h dehydrogenase (quinone) Tph_c13250 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Tph_c13270 ENOG4105C8Y Acetylornithine aminotransferase Tph_c13300 ENOG4105HF0 Membrane Tph_c13310 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Tph_c13320 ENOG4105VJV 50s ribosomal protein L35 Tph_c13330 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Tph_c13340 ENOG4108RWN rrna methyltransferase Tph_c13350 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Tph_c13360 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Tph_c13370 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) Tph_c13380 ENOG4105DCG PHP domain protein Tph_c13400 ENOG4105WMR Protein CrcB homolog Tph_c13410 ENOG4105WMR Protein CrcB homolog Tph_c13420 ENOG4105KJJ Uncharacterized ACR, COG1993 Tph_c13430 ENOG4105CFP Peptidase U32 Tph_c13440 ENOG4105C98 muts2 protein Tph_c13450 ENOG4108RAV Conserved protein Tph_c13460 ENOG4105D1H recombination factor protein RarA Tph_c13500 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme Tph_c13510 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme Tph_c13540 ENOG4105S7A ErfK ybiS ycfS ynhG family protein Tph_c13610 ENOG4107EFR Flavocytochrome c Tph_c13620 ENOG41085W3 Transposase Tph_c13670 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Tph_c13690 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Tph_c13700 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Tph_c13710 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Tph_c13720 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Tph_c13730 ENOG4105CHR reductase Tph_c13740 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Tph_c13750 ENOG4105EA8 2-Nitropropane dioxygenase Tph_c13760 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Tph_c13780 ENOG4105CXI aluminum resistance protein Tph_c13790 ENOG4106F1P AAA ATPase, central domain protein Tph_c13800 ENOG4105E90 ABC transporter Tph_c13810 ENOG4108IY8 ABC, transporter Tph_c13820 ENOG4105D7T ABC transporter Tph_c13840 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Tph_c13850 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Tph_c13860 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Tph_c13870 ENOG4105DGU Histone deacetylase Tph_c13890 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Tph_c13900 ENOG4105WZB UPF0342 protein Tph_c13910 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Tph_c14000 ENOG4105VB9 50S ribosomal protein l28 Tph_c14010 ENOG4108RE9 Phosphodiesterase Tph_c14020 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Tph_c14030 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Tph_c14040 ENOG4108R6K riboflavin synthase, subunit alpha Tph_c14210 ENOG4105DJV ribulose-phosphate 3-epimerase Tph_c14220 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Tph_c14230 ENOG4105D9P serine threonine protein kinase Tph_c14250 ENOG4107QHZ cell cycle protein Tph_c14270 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Tph_c14280 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Tph_c14290 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Tph_c14300 ENOG4105C25 Primosomal protein n' Tph_c14310 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Tph_c14320 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Tph_c14330 ENOG41084KE Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Tph_c14340 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Tph_c14350 ENOG4105KC4 UPF0296 protein Tph_c14360 ENOG4105DSJ YicC domain protein Tph_c14370 ENOG4105CHM Aminotransferase Tph_c14380 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Tph_c14390 ENOG4105F23 Fibronectin-binding protein Tph_c14410 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Tph_c14420 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Tph_c14430 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) Tph_c14440 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) Tph_c14450 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Tph_c14460 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Tph_c14470 ENOG4105CD3 dihydroorotase Tph_c14480 ENOG4105CXT aspartate transcarbamylase Tph_c14490 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Tph_c14510 ENOG4105CPI Metal Dependent Phosphohydrolase Tph_c14520 ENOG4105C59 p-type ATPase Tph_c14690 ENOG4105DY9 regulatoR Tph_c14850 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Tph_c14880 ENOG4107QIZ NADH dehydrogenase Tph_c14890 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit Tph_c14920 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Tph_c14930 ENOG4105EUJ GTP cyclohydrolase i Tph_c14950 ENOG4105I3K Ferric uptake regulator, Fur family Tph_c14960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tph_c15020 ENOG4105CIH Imidazole acetol-phosphate transaminase Tph_c15030 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Tph_c15040 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Tph_c15070 ENOG4105CHM Aminotransferase Tph_c15130 ENOG4107VP5 methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase Tph_c15140 ENOG4106HYN CO dehydrogenase acetyl-CoA synthase delta subunit Tph_c15160 ENOG4105EYX Acetyl-CoA decarbonylase synthase complex subunit gamma Tph_c15170 ENOG4105E8X CO dehydrogenase acetyl-CoA synthase complex beta subunit Tph_c15180 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit Tph_c15190 ENOG41080XS Cobyrinic acid ac-diamide synthase Tph_c15210 ENOG4105EPR degv family Tph_c15240 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Tph_c15260 ENOG4105BZU Histidine kinase Tph_c15270 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Tph_c15280 ENOG4108UMR transcriptional regulator AsnC family Tph_c15290 ENOG4108ZGY Transcriptional regulator (AsnC family) Tph_c15300 ENOG4105D52 delta-aminolevulinic acid dehydratase Tph_c15330 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Tph_c15340 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Tph_c15350 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Tph_c15390 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Tph_c15420 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Tph_c15450 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Tph_c15470 ENOG41086B8 CoB-CoM heterodisulfide reductase Tph_c15490 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Tph_c15540 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Tph_c15550 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Tph_c15560 ENOG4105D6E homoserine dehydrogenase Tph_c15570 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) Tph_c15580 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Tph_c15590 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Tph_c15640 ENOG4105S2F Tph_c15690 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Tph_c15710 ENOG4105CAT Cytidine monophosphate kinase Tph_c15720 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Tph_c15730 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Tph_c15740 ENOG4105Z5G 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Tph_c15750 ENOG4105KHN chorismate mutase Tph_c15790 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Tph_c15800 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Tph_c15810 ENOG4105EHG Permease protein Tph_c15820 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Tph_c15830 ENOG4105FE9 pseudouridine synthase Tph_c15860 ENOG4108JIC nucleoside recognition domain protein Tph_c15870 ENOG4105DZ1 carboxypeptidase Tph_c15880 ENOG4105KBJ sporulation protein ytfj Tph_c15900 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Tph_c15910 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Tph_c15920 ENOG4105C31 Tryptophanyl-tRNA synthetase Tph_c15930 ENOG4108Z4T Peptidase M50 Tph_c15940 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Tph_c15950 ENOG4105CIZ coA-substrate-specific enzyme activase Tph_c15990 ENOG4105CZ3 stage V sporulation protein ad Tph_c16000 ENOG41090VF Stage v sporulation protein ac Tph_c16030 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Tph_c16050 ENOG4105DZ1 carboxypeptidase Tph_c16070 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Tph_c16080 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tph_c16100 ENOG4105MZ9 stage II sporulation protein m Tph_c16150 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) Tph_c16160 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Tph_c16170 ENOG4105CKK Glycosyl transferase, family 2 Tph_c16200 ENOG4107QQR Sporulation Tph_c16210 ENOG4105S1Z Stage IV sporulation protein B Tph_c16220 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Tph_c16230 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Tph_c16240 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Tph_c16250 ENOG4105DX0 Hemolysin A Tph_c16260 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Tph_c16300 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Tph_c16310 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Tph_c16320 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Tph_c16330 ENOG4105M7K Involved in the transcription termination process (By similarity) Tph_c16360 ENOG4108ZSR alkaline shock protein Tph_c16370 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Tph_c16380 ENOG4107QSA Oxaloacetate decarboxylase Tph_c16430 ENOG4105KQ4 Stage iii sporulation protein ad Tph_c16440 ENOG4108CQH stage III sporulation protein AC Tph_c16460 ENOG4105CD2 stage iii sporulation protein aa Tph_c16480 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Tph_c16490 ENOG4105DC7 peptidase M24 Tph_c16500 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Tph_c16510 ENOG4105CMS peptidase U62, modulator of DNA gyrase Tph_c16520 ENOG4105D1U peptidase U62 modulator of DNA gyrase Tph_c16570 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Tph_c16620 ENOG4108VAU general secretion pathway protein G Tph_c16640 ENOG4105CZX twitching motility protein Tph_c16650 ENOG4107QHF type ii secretion system protein e Tph_c16660 ENOG4105CZX twitching motility protein Tph_c16670 ENOG4105D49 3-dehydroquinate synthase Tph_c16680 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Tph_c16690 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Tph_c16700 ENOG4105E2X shikimate dehydrogenase Tph_c16720 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Tph_c16730 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase Tph_c16780 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tph_c16790 ENOG4107Y5K Resolvase Tph_c16830 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tph_c16860 ENOG4107XRG penicillin-binding protein Tph_c16880 ENOG4105HHA aminodeoxychorismate lyase Tph_c16890 ENOG41073R8 VanW family Tph_c16900 ENOG41085AS UPF0473 protein Tph_c16910 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Tph_c16920 ENOG4105CPC Aldo Keto reductase Tph_c16930 ENOG4105VBH UPF0297 protein Tph_c16940 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Tph_c16970 ENOG4105D7A ATP-binding protein Tph_c16990 ENOG4105D9P serine threonine protein kinase Tph_c17000 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Tph_c17060 ENOG4108DBC nitroreductase Tph_c17070 ENOG4108JQ7 (ABC) transporter Tph_c17080 ENOG4105C3U ABC transporter Tph_c17090 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tph_c17100 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Tph_c17110 ENOG4105DEF Extracellular solute-binding protein, family 5 Tph_c17140 ENOG4105EJQ L-serine dehydratase Tph_c17160 ENOG4108UIC UPF0340 protein Tph_c17170 ENOG4105DF9 Lipoate-protein, ligase Tph_c17190 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Tph_c17200 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Tph_c17210 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Tph_c17220 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Tph_c17250 ENOG4105C02 permease Tph_c17270 ENOG41060CR Tph_c17290 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Tph_c17300 ENOG4107QI6 Cysteine desulfurase Tph_c17320 ENOG4105K63 Thioredoxin Tph_c17340 ENOG4105EET magnesium chelatase Tph_c17360 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Tph_c17410 ENOG4105DY9 regulatoR Tph_c17480 ENOG4105D5G Transposase Tph_c17640 ENOG4108K9K Uncharacterised protein family (UPF0236) Tph_c17650 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Tph_c17700 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase Tph_c17780 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Tph_c17790 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase Tph_c17810 ENOG4105DWF phosphomethylpyrimidine kinase Tph_c17830 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Tph_c17840 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Tph_c17860 ENOG4105D41 biosynthesis protein thiH Tph_c17870 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Tph_c17900 ENOG4105EU0 Major facilitator Superfamily Tph_c17930 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Tph_c17940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tph_c17960 ENOG4105C3J Cysteine desulfurase Tph_c17980 ENOG4105D6J arsenicaL-resistance protein Tph_c18040 ENOG4105CH7 arginosuccinase Tph_c18050 ENOG4105E4C Lytic transglycosylase catalytic Tph_c18060 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Tph_c18080 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Tph_c18100 ENOG4105PNM synthesis protein Tph_c18120 ENOG4105CDY transcriptional regulatory protein Tph_c18130 ENOG4107RA1 nh(3)-dependent nad( ) synthetase Tph_c18180 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Tph_c18210 ENOG4105GTG Isochorismatase Tph_c18270 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Tph_c18320 ENOG4105C7J ABC transporter, permease Tph_c18330 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Tph_c18360 ENOG4105EGD dinuclear metal center protein, YbgI family Tph_c18380 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Tph_c18420 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Tph_c18440 ENOG4107QIZ NADH dehydrogenase Tph_c18460 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit Tph_c18500 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Tph_c18530 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Tph_c18540 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Tph_c18550 ENOG4105K8N protein family UPF0079, ATPase Tph_c18560 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Tph_c18570 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Tph_c18580 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Tph_c18600 ENOG4108V3W Chemotaxis protein, CheW Tph_c18610 ENOG4105C3G gtp-binding protein Tph_c18620 ENOG4105CPC Aldo Keto reductase Tph_c18630 ENOG4105BZG amino acid carrier protein Tph_c18650 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Tph_c18660 ENOG4105EPR degv family Tph_c18670 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Tph_c18680 ENOG4107XGZ Hydrolase Tph_c18690 ENOG4107S6Z Na H antiporter Tph_c18780 ENOG4105CIZ coA-substrate-specific enzyme activase Tph_c18810 ENOG4108IG5 Transcriptional regulator Tph_c18850 ENOG4105CE1 Ferrous iron transport protein b Tph_c18860 ENOG4105CE1 Ferrous iron transport protein b Tph_c18900 ENOG4105EET magnesium chelatase Tph_c18970 ENOG4105V0P CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) Tph_c19080 ENOG4105CEY Amp-dependent synthetase and ligase Tph_c19110 ENOG4105BZ1 (ABC) transporter Tph_c19120 ENOG4105BZ1 (ABC) transporter Tph_c19130 ENOG4108U05 Transcriptional regulator Tph_c19140 ENOG4105C6T cysteine synthase Tph_c19160 ENOG41082YX Transcriptional regulator, arsr family Tph_c19200 ENOG4107QI6 Cysteine desulfurase Tph_c19210 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) Tph_c19230 ENOG4105VFE sira family Tph_c19400 ENOG4105CEC DNA methylase N-4 N-6 Tph_c19410 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) Tph_c19510 ENOG4107U32 Beta-lactamase domain protein Tph_c19580 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Tph_c19600 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Tph_c19620 ENOG4105C7S Dehydrogenase Tph_c19630 ENOG4106Z86 ATP-nad acox kinase Tph_c19650 ENOG4107RUY (E1 component), alpha subunit Tph_c19720 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Tph_c19730 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Tph_c19780 ENOG4105K67 small basic protein Tph_c19800 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Tph_c19810 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Tph_c19820 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tph_c19830 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tph_c19840 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Tph_c19870 ENOG4105C7K acetolactate synthase Tph_c19880 ENOG4105C01 Dihydroxy-acid dehydratase Tph_c19890 ENOG4105CM2 brancheD-chain amino acid aminotransferase Tph_c19910 ENOG4105KY8 Rubrerythrin Tph_c19940 ENOG4107Y5K Resolvase Tph_c20010 ENOG4108K9K Uncharacterised protein family (UPF0236) Tph_c20050 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tph_c20110 ENOG410836F Transposase Tph_c20130 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c20140 ENOG4107XVH Transcriptional regulator Tph_c20150 ENOG4105C94 Transporter Tph_c20170 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system Tph_c20180 ENOG4108IJ8 ABC transporter Tph_c20190 ENOG4105E90 ABC transporter Tph_c20200 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tph_c20250 ENOG4105DV9 Methylaspartate ammonia-lyase Tph_c20260 ENOG4105DJI Methylaspartate mutase, E subunit Tph_c20280 ENOG4107YT1 Glutamate mutase subunit sigma Tph_c20290 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c20320 ENOG4105CTU Proline racemase Tph_c20340 ENOG4105CGP Urocanate hydratase Tph_c20350 ENOG4105WE2 aldehyde ferredoxin oxidoreductase Tph_c20380 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system Tph_c20390 ENOG4105E90 ABC transporter Tph_c20400 ENOG4108IJ8 ABC transporter Tph_c20420 ENOG4108JUB Transcriptional regulator Tph_c20430 ENOG410908R Methenyltetrahydrofolate cyclohydrolase Tph_c20440 ENOG4105CCS Glutamate formiminotransferase Tph_c20450 ENOG4105CI2 imidazolone-5-propionate hydrolase Tph_c20460 ENOG4105C84 Histidine ammonia-lyase Tph_c20470 ENOG4107RBB ABC transporter, permease Tph_c20480 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Tph_c20510 ENOG4105C3M thioredoxin reductase Tph_c20540 ENOG4105F0I Aminotransferase Tph_c20550 ENOG4105CRQ synthase (Component I) Tph_c20560 ENOG4105DDQ anthranilate synthase Tph_c20580 ENOG4107QI6 Cysteine desulfurase Tph_c20610 ENOG4107VQW regulatoR Tph_c20620 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Tph_c20640 ENOG4105C2F Histidine kinase Tph_c20650 ENOG4105VPX protein, conserved in bacteria Tph_c20670 ENOG4105C59 p-type ATPase Tph_c20790 ENOG4108Y5D Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Tph_c20800 ENOG4105CZA synthase Tph_c20820 ENOG4105MZG transcriptional modulator of maze toxin, mazf Tph_c20830 ENOG4106A2Z transcriptional regulator antitoxin, MazE Tph_c20850 ENOG4105C0D helicase Tph_c20870 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tph_c20900 ENOG4105WEF catalase Tph_c20950 ENOG4105DU6 RNA polymerase Tph_c21000 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) Tph_c21010 ENOG41080Y5 BioY family Tph_c21020 ENOG4108JJB ABC transporter Tph_c21030 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Tph_c21060 ENOG4107YU2 histidine triad (hIT) protein Tph_c21080 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Tph_c21090 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Tph_c21100 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Tph_c21110 ENOG4105CFG Acts as a chaperone (By similarity) Tph_c21120 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Tph_c21130 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Tph_c21140 ENOG4105CSA Coproporphyrinogen iii oxidase Tph_c21150 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Tph_c21160 ENOG4105CJR Integral membrane protein (MviN Tph_c21230 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Tph_c21240 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Tph_c21280 ENOG4105CN5 Metallo-Beta-Lactamase Tph_c21320 ENOG4108HM5 NADH-ubiquinone oxidoreductase chain 49kDa Tph_c21340 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Tph_c21360 ENOG4105D65 subunit l Tph_c21380 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Tph_c21390 ENOG4105C8T Leucyl-tRNA synthetase Tph_c21410 ENOG4108KS2 transglutaminase domain protein Tph_c21500 ENOG4105WH1 Two component transcriptional regulator luxr family Tph_c21510 ENOG4105CPI Metal Dependent Phosphohydrolase Tph_c21530 ENOG4108WF2 Metal Dependent Phosphohydrolase Tph_c21540 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Tph_c21550 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Tph_c21560 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Tph_c21570 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Tph_c21580 ENOG4105K46 50S ribosomal protein l27 Tph_c21600 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Tph_c21650 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Tph_c21660 ENOG4105GKE subunit e Tph_c21670 ENOG4107QIZ NADH dehydrogenase Tph_c21690 ENOG4105VUF Transcriptional regulator Tph_c21730 ENOG4107QW4 alcohol dehydrogenase Tph_c21840 ENOG4105C2C drug resistance transporter, Bcr CflA Tph_c21880 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Tph_c21890 ENOG4105E5H Transposase Tph_c21970 ENOG4105VTR Integrase Tph_c22100 ENOG4105CT1 (ABC) transporter Tph_c22110 ENOG4105E5Q amino acid AbC transporter Tph_c22120 ENOG4105CDA abc transporter atp-binding protein Tph_c22150 ENOG4105MQ3 flagellar protein FliS Tph_c22170 ENOG4107RT6 flagellar hook-associated Tph_c22190 ENOG4107RT6 flagellar hook-associated Tph_c22230 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Tph_c22270 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Tph_c22280 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Tph_c22290 ENOG4105MSI germination protein ypeb Tph_c22310 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) Tph_c22320 ENOG4105CFP Peptidase U32 Tph_c22330 ENOG4105C8Y Acetylornithine aminotransferase Tph_c22340 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Tph_c22360 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Tph_c22400 ENOG4105FAV ABC, transporter Tph_c22410 ENOG4105FDK ABC transporter Tph_c22420 ENOG4105DSE periplasmic solute binding protein Tph_c22430 ENOG4105N80 Ferric uptake regulator, Fur family Tph_c22440 ENOG4108UQV Membrane Tph_c22460 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Tph_c22580 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Tph_c22610 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Tph_c22620 ENOG4105D01 (LipO)protein Tph_c22630 ENOG4108UMI ABC transporter, permease Tph_c22640 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Tph_c22650 ENOG4108QBV Monogalactosyldiacylglycerol synthase Tph_c22660 ENOG4107GBW cellulosome anchoring protein cohesin Tph_c22670 ENOG4108USZ hydrogenase Tph_c22690 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Tph_c22700 ENOG4105KG3 cytidine deaminase Tph_c22710 ENOG4107YR5 Diacylglycerol kinase Tph_c22720 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Tph_c22730 ENOG4105CTJ Metal Dependent Phosphohydrolase Tph_c22740 ENOG4105C9A Phoh family Tph_c22760 ENOG41068P3 sporulation protein YqfC Tph_c22780 ENOG4105VCC 30S ribosomal protein S21 Tph_c22830 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Tph_c22850 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 Tph_c22920 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Tph_c23010 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase Tph_c23020 ENOG4105XSJ toxin secretion phage lysis holin Tph_c23030 ENOG4107BJW polysaccharide deacetylase Tph_c23150 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tph_c23160 ENOG4105EFC phage portal protein HK97 family Tph_c23180 ENOG4105CAR Terminase, large subunit Tph_c23380 ENOG4108RAC Rubrerythrin Tph_c23460 ENOG4107YH3 SUF system FeS assembly protein, NifU family Tph_c23470 ENOG4105VYW UPF0251 protein Tph_c23550 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) Tph_c23580 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tph_c23600 ENOG4105C19 ABC transporter Tph_c23640 ENOG4105F3H Histidine kinase Tph_c23670 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Tph_c23740 ENOG4105C32 Amino acid ABC transporter (Permease) Tph_c23750 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Tph_c23760 ENOG4105C0Z ABC transporter Tph_c23770 ENOG4105E0Y RtcB Protein Tph_c23800 ENOG4105DZS Phenylacetate-CoA ligase Tph_c23830 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) Tph_c23890 ENOG4108PCN EamA-like transporter family Tph_c23900 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Tph_c23920 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Tph_c23930 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Tph_c23940 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) Tph_c23950 ENOG4105DRR Transcriptional regulator, GntR family Tph_c23980 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Tph_c23990 ENOG4105JSC dimethylmenaquinone methyltransferase Tph_c24000 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Tph_c24010 ENOG4108IYU L-aspartate oxidase Tph_c24020 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) Tph_c24060 ENOG4108K8K Transcriptional regulator Tph_c24070 ENOG4107EFR Flavocytochrome c Tph_c24080 ENOG4105WG9 Conserved Protein Tph_c24120 ENOG4105MZG transcriptional modulator of maze toxin, mazf Tph_c24210 ENOG410836F Transposase Tph_c24250 ENOG410836F Transposase Tph_c24270 ENOG4105E5H Transposase Tph_c24380 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) Tph_c24390 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Tph_c24490 ENOG4108W8W CRISPR-associated RAMP protein, Csm3 family Tph_c24510 ENOG4105G15 CRISPR-associated RAMP protein, Csm5 family Tph_c24540 ENOG4108W8W CRISPR-associated RAMP protein, Csm3 family Tph_c24630 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Tph_c24660 ENOG4108QG2 Membrane Tph_c24690 ENOG4105C7N Xanthine uracil vitamin C permease Tph_c24760 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Tph_c24800 ENOG4107QWP ABC-2 type transporter Tph_c24810 ENOG4105CJ1 ABC, transporter Tph_c24820 ENOG4105CJ1 ABC, transporter Tph_c24830 ENOG4105D0S secretion protein (HlyD Tph_c24870 ENOG4105VEQ Cold shock protein Tph_c24960 ENOG4105EW6 flavin reductase domain protein, FMN-binding Tph_c24980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tph_c25090 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Tph_c25140 ENOG4108JQ7 (ABC) transporter Tph_c25190 ENOG4105DEF Extracellular solute-binding protein, family 5 Tph_c25220 ENOG4105CJ1 ABC, transporter Tph_c25240 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tph_c25290 ENOG4108JQ7 (ABC) transporter Tph_c25300 ENOG4105C3U ABC transporter Tph_c25310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tph_c25330 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tph_c25340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Tph_c25370 ENOG4105DVT helicase Tph_c25410 ENOG4105D9P serine threonine protein kinase Tph_c25420 ENOG4105CH7 arginosuccinase Tph_c25430 ENOG4105CDH Citrulline--aspartate ligase Tph_c25440 ENOG4105DBV ornithine carbamoyltransferase Tph_c25450 ENOG4105C8Y Acetylornithine aminotransferase Tph_c25460 ENOG4105CAS nag kinase Tph_c25470 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Tph_c25480 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Tph_c25500 ENOG4105NBF ammecr1 domain protein Tph_c25540 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Tph_c25550 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Tph_c25560 ENOG4108ZT0 50S ribosomal protein l17 Tph_c25570 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tph_c25580 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Tph_c25590 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Tph_c25600 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Tph_c25610 ENOG41067V7 50S ribosomal protein L36 Tph_c25620 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Tph_c25650 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Tph_c25660 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Tph_c25670 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Tph_c25680 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Tph_c25690 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Tph_c25700 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Tph_c25710 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Tph_c25720 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Tph_c25730 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Tph_c25740 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Tph_c25750 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Tph_c25760 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Tph_c25770 ENOG41082SA 50s ribosomal protein l29 Tph_c25780 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Tph_c25790 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Tph_c25810 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Tph_c25820 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Tph_c25830 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Tph_c25840 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Tph_c25850 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Tph_c25860 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Tph_c25870 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Tph_c25880 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Tph_c25890 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Tph_c25900 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Tph_c25910 ENOG4105XPM ribosomal protein Tph_c25920 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tph_c25930 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tph_c26010 ENOG4108K9K Uncharacterised protein family (UPF0236) Tph_c26050 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Tph_c26060 ENOG4108VZM 50s ribosomal protein L10 Tph_c26070 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Tph_c26080 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Tph_c26090 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Tph_c26110 ENOG4105WDJ 50S ribosomal protein L33 Tph_c26180 ENOG4105CRK lysyL-tRNA synthetase Tph_c26250 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Tph_c26260 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Tph_c26270 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) Tph_c26280 ENOG4108JPZ Monovalent cation H antiporter subunit D Tph_c26290 ENOG4107TDF Formate hydrogenlyase subunit 4 Tph_c26300 ENOG4107WQX hydrogenase 4 membrane subunit Tph_c26310 ENOG4108JPZ Monovalent cation H antiporter subunit D Tph_c26330 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tph_c26350 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Tph_c26360 ENOG4105I6X formate hydrogenlyase maturation Tph_c26370 ENOG4108MG9 hydrogenase 3 maturation protease Tph_c26380 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Tph_c26390 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family Tph_c26400 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Tph_c26410 ENOG4105E0C molybdate abc transporter Tph_c26420 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Tph_c26430 ENOG4105CHR reductase Tph_c26440 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) Tph_c26450 ENOG41088YS Glycosyl transferase (Group 1 Tph_c26480 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Tph_c26490 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Tph_c26500 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Tph_c26510 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Tph_c26520 ENOG4105DK0 Indole-3-glycerol phosphate synthase Tph_c26530 ENOG4105DDQ anthranilate synthase Tph_c26540 ENOG4105CRQ synthase (Component I) Tph_c26550 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Tph_c26560 ENOG4107T5V SNARE associated Golgi Tph_c26580 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Tph_c26610 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Tph_c26620 ENOG4108IYU L-aspartate oxidase Tph_c26630 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Tph_c26650 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Tph_c26670 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Tph_c26680 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Tph_c26690 ENOG4105CQC Prephenate dehydratase Tph_c26700 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Tph_c26710 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Tph_c26720 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Tph_c26740 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Tph_c26750 ENOG4105KRF dihydroneopterin aldolase Tph_c26760 ENOG4105EEI dihydropteroate synthase Tph_c26770 ENOG4105KFW domain protein Tph_c26780 ENOG4105CKU formyltetrahydrofolate synthetase Tph_c26800 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Tph_c26820 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Tph_c26870 ENOG4105VRS hydrolase family 18 Tph_c26880 ENOG4107RSS Hydrogenase accessory protein HypB Tph_c26890 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) Tph_c26910 ENOG4105DPX Hydrogenase, large subunit Tph_c26930 ENOG4107SHJ sulfite reductase subunit b Tph_c26950 ENOG4105C9X ppx gppa phosphatase Tph_c26960 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) Tph_c27000 ENOG4105C6T cysteine synthase Tph_c27010 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Tph_c27020 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Tph_c27070 ENOG4108JUB Transcriptional regulator Tph_c27110 ENOG4105CGA flagellar basal-body rod protein FlgG Tph_c27120 ENOG4105CGA flagellar basal-body rod protein FlgG Tph_c27140 ENOG4105MT0 Sporulation transcriptional regulator spoiiid Tph_c27210 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Tph_c27220 ENOG4105KST dependent repressor Tph_c27290 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Tph_c27310 ENOG4105CVM Molybdenum cofactor synthesis domain protein Tph_c27330 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Tph_c27370 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Tph_c27380 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Tph_c27390 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Tph_c27400 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Tph_c27410 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Tph_c27420 ENOG4105VH4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Tph_c27430 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) Tph_c27460 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Tph_c27490 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Tph_c27500 ENOG4108YZG isomerase Tph_c27530 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Tph_c27550 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Tph_c27560 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Tph_c27570 ENOG4105CBJ Metal-dependent enzyme Tph_c27580 ENOG41082DI 50s ribosomal protein l31 Tph_c27590 ENOG4105D0C transport protein Tph_c27600 ENOG4107VP5 methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase Tph_c27610 ENOG4105C6K Malic enzyme Tph_c27620 ENOG4105QUH Domain of unknown function (DUF2088) Tph_c27670 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c27700 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c27730 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Tph_c27740 ENOG4105W8H transhydrogenase (subunit alpha Tph_c27750 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Tph_c27760 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c27780 ENOG4108JUA Transcriptional regulator Tph_c27790 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Tph_c27800 ENOG4105DR5 peptidase Tph_c27810 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Tph_c27820 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Tph_c27850 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Tph_c27870 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Tph_c27880 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein Tph_c27900 ENOG4105BZU Histidine kinase Tph_c27960 ENOG4105CKI cobalamin synthesis protein Tph_c27980 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c27990 ENOG4105FDP GntR family transcriptional regulator Tph_c28000 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Tph_c28010 ENOG4108Q52 Methyltransferase cognate corrinoid protein Tph_c28020 ENOG4108SHJ s-layer protein Tph_c28040 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Tph_c28070 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Tph_c28100 ENOG4105DR5 peptidase Tph_c28140 ENOG4105EMN RNA polymerase sigma factor Tph_c28160 ENOG4108SHJ s-layer protein Tph_c28210 ENOG41082I2 s4 domain protein Tph_c28230 ENOG4108IY2 MazG family Tph_c28240 ENOG4105CKP Polysaccharide Biosynthesis Protein Tph_c28250 ENOG4108M14 stage v sporulation protein t Tph_c28260 ENOG4105EIN peptidylprolyl cis-trans isomerase Tph_c28270 ENOG4108JA2 transcriptioN-repair coupling factor Tph_c28300 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Tph_c28310 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Tph_c28330 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Tph_c28340 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Tph_c28350 ENOG4105K4W Could be involved in septation (By similarity) Tph_c28370 ENOG4105DRR Transcriptional regulator, GntR family Tph_c28380 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Tph_c28390 ENOG4107RRY Cyanophycin synthetase Tph_c28400 ENOG4105DDG Cyanophycinase Tph_c28420 ENOG4108ZXQ stage ii sporulation protein r Tph_c28430 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein Tph_c28440 ENOG4105K4I Scp-like extracellular Tph_c28470 ENOG41080DW Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Tph_c28530 ENOG4105D78 K07001 NTE family protein Tph_c28600 ENOG4105K4I Scp-like extracellular Tph_c28620 ENOG4105W42 Veg protein Tph_c28630 ENOG4105XFA sporulation peptidase YabG Tph_c28660 ENOG4105F6S Spore photoproduct lyase Tph_c28680 ENOG4108XRC Protein of unknown function (DUF458) Tph_c28690 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Tph_c28700 ENOG41069ER domain protein Tph_c28710 ENOG41069ER domain protein Tph_c28720 ENOG4105F8V Hydrolase, tatD family Tph_c28740 ENOG4108K9K Uncharacterised protein family (UPF0236) Tph_c28750 ENOG4105KRN Transcriptional regulator, abrb family Tph_c28760 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Tph_c28770 ENOG4105MA4 psp1 domain protein Tph_c28780 ENOG4107QRG dna polymerase iii Tph_c28790 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Tph_c28800 ENOG4105CXN decarboxylase Tph_c28840 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) Tph_c28850 ENOG4105C1A potassium transporter peripheral membrane Tph_c28910 ENOG4105D1F ATP-binding protein Tph_c28930 ENOG4107ZYR domain protein Tph_c28960 ENOG4105CZN Potassium uptake protein Tph_c28990 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Tph_c29000 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Tph_c29010 ENOG4105C6E dna polymerase iii Tph_c29040 ENOG4107S7H nh(3)-dependent nad( ) synthetase Tph_c29050 ENOG4105D64 Mechanosensitive ion channel Tph_c29070 ENOG4108Z6B deaminase Tph_c29150 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)