locus-tag	class	description
Tph_c00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tph_c00020	COG0592	DNA-directed DNA polymerase activity
Tph_c00050	COG0187	DNA topoisomerase II activity
Tph_c00060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tph_c00130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tph_c00140	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Tph_c00150	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Tph_c00170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tph_c00180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tph_c00260	COG0594	ribonuclease P activity
Tph_c00270	COG0706	membrane insertase activity
Tph_c00280	COG1847	R3H domain protein
Tph_c00290	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tph_c00300	COG0357	Ribosomal RNA small subunit methyltransferase G
Tph_c00310	COG1475	DNA binding
Tph_c00330	COG1192	Involved in chromosome partitioning
Tph_c00340	COG1475	DNA binding
Tph_c00360	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Tph_c00370	COG1691	(AIR) carboxylase
Tph_c00390	COG0739	heme binding
Tph_c00430	COG1921	L-seryl-tRNASec selenium transferase activity
Tph_c00480	COG0411	ABC transporter
Tph_c00500	COG0517	IMP dehydrogenase activity
Tph_c00520	COG1053	succinate dehydrogenase
Tph_c00540	COG2508	Transcriptional regulator
Tph_c00600	COG1615	UPF0182 protein
Tph_c00670	COG0709	Synthesizes selenophosphate from selenide and ATP
Tph_c00680	COG0425	Belongs to the sulfur carrier protein TusA family
Tph_c00700	COG0360	Binds together with S18 to 16S ribosomal RNA
Tph_c00710	COG0629	single-stranded DNA binding
Tph_c00720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tph_c00760	COG1598	PFAM Uncharacterised protein family UPF0150
Tph_c00770	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Tph_c00780	COG0359	binds to the 23S rRNA
Tph_c00790	COG0470	DNA polymerase III
Tph_c00790	COG1067	ATP-dependent peptidase activity
Tph_c00800	COG0305	Participates in initiation and elongation during chromosome replication
Tph_c00850	COG1309	transcriptional regulator
Tph_c00890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tph_c00940	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tph_c01000	COG1598	PFAM Uncharacterised protein family UPF0150
Tph_c01070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tph_c01110	COG3835	regulator
Tph_c01120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tph_c01140	COG2508	Transcriptional regulator
Tph_c01160	COG1053	succinate dehydrogenase
Tph_c01170	COG1053	succinate dehydrogenase
Tph_c01180	COG1053	succinate dehydrogenase
Tph_c01200	COG1120	ATPase activity
Tph_c01210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tph_c01230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tph_c01290	COG0437	4 iron, 4 sulfur cluster binding
Tph_c01320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Tph_c01450	COG0477	Major facilitator Superfamily
Tph_c01480	COG0746	molybdenum cofactor guanylyltransferase activity
Tph_c01490	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tph_c01500	COG0303	'Molybdopterin
Tph_c01510	COG0303	'Molybdopterin
Tph_c01560	COG1120	ATPase activity
Tph_c01580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tph_c01600	COG0725	ABC transporter, periplasmic molybdate-binding protein
Tph_c01620	COG3842	ATPase activity
Tph_c01630	COG0315	cyclic pyranopterin monophosphate synthase activity
Tph_c01650	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tph_c01670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tph_c01720	COG0437	4 iron, 4 sulfur cluster binding
Tph_c01740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tph_c01750	COG0746	molybdenum cofactor guanylyltransferase activity
Tph_c01760	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tph_c01770	COG0303	'Molybdopterin
Tph_c01800	COG5012	cobalamin binding
Tph_c01870	COG0745	RESPONSE REGULATOR receiver
Tph_c01900	COG3481	metal-dependent phosphohydrolase, HD sub domain
Tph_c01910	COG2508	Transcriptional regulator
Tph_c01960	COG1598	PFAM Uncharacterised protein family UPF0150
Tph_c02100	COG0840	transmembrane signaling receptor activity
Tph_c02230	COG1363	Peptidase, m42
Tph_c02240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tph_c02260	COG1309	transcriptional regulator
Tph_c02310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tph_c02420	COG5002	protein histidine kinase activity
Tph_c02430	COG0745	RESPONSE REGULATOR receiver
Tph_c02530	COG0513	Belongs to the DEAD box helicase family
Tph_c02580	COG4464	protein tyrosine phosphatase activity
Tph_c02640	COG3944	biosynthesis protein
Tph_c02650	COG0489	protein tyrosine kinase activity
Tph_c02670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tph_c02680	COG1086	Polysaccharide biosynthesis protein
Tph_c02690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Tph_c02780	COG0438	transferase activity, transferring glycosyl groups
Tph_c02810	COG0438	transferase activity, transferring glycosyl groups
Tph_c02930	COG0840	transmembrane signaling receptor activity
Tph_c03090	COG2199	diguanylate cyclase activity
Tph_c03090	COG2203	Gaf domain
Tph_c03240	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tph_c03310	COG0534	Mate efflux family protein
Tph_c03330	COG1078	dGTPase activity
Tph_c03340	COG3328	transposase activity
Tph_c03360	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Tph_c03360	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Tph_c03390	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Tph_c03420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tph_c03430	COG1120	ATPase activity
Tph_c03490	COG1131	(ABC) transporter
Tph_c03520	COG0747	negative chemotaxis
Tph_c03530	COG0601	transmembrane transport
Tph_c03560	COG4608	Belongs to the ABC transporter superfamily
Tph_c03570	COG2226	methyltransferase
Tph_c03600	COG5012	cobalamin binding
Tph_c03610	COG1410	methionine synthase
Tph_c03610	COG0646	methionine synthase
Tph_c03620	COG5012	cobalamin binding
Tph_c03640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tph_c03710	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Tph_c03720	COG0542	response to heat
Tph_c03740	COG0778	Nitroreductase
Tph_c03750	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Tph_c03790	COG3976	FMN-binding domain protein
Tph_c03790	COG1053	succinate dehydrogenase
Tph_c03810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Tph_c03820	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Tph_c03840	COG1329	Transcriptional regulator
Tph_c03850	COG4956	integral membrane protein (PIN domain superfamily)
Tph_c03860	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tph_c03860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tph_c03880	COG3290	protein histidine kinase activity
Tph_c03880	COG3829	transcription factor binding
Tph_c03920	COG0501	Belongs to the peptidase M48B family
Tph_c03940	COG0616	signal peptide processing
Tph_c04000	COG0459	protein refolding
Tph_c04010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tph_c04050	COG1032	radical SAM domain protein
Tph_c04110	COG1584	GPR1 FUN34 yaaH family protein
Tph_c04120	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Tph_c04130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tph_c04150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tph_c04180	COG2414	aldehyde ferredoxin oxidoreductase
Tph_c04200	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tph_c04360	COG1122	ATPase activity
Tph_c04430	COG3103	Sh3 type 3 domain protein
Tph_c04430	COG1388	LysM domain
Tph_c04430	COG0791	NLP P60 protein
Tph_c04450	COG2226	methyltransferase
Tph_c04460	COG1846	Transcriptional regulator
Tph_c04480	COG2204	response regulator
Tph_c04480	COG5564	TIM-barrel signal transduction protein
Tph_c04500	COG2045	Belongs to the ComB family
Tph_c04510	COG5564	TIM-barrel signal transduction protein
Tph_c04520	COG1850	ribulose-bisphosphate carboxylase activity
Tph_c04560	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Tph_c04600	COG0840	transmembrane signaling receptor activity
Tph_c04630	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tph_c04640	COG0740	serine-type endopeptidase activity
Tph_c04650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tph_c04660	COG1067	ATP-dependent peptidase activity
Tph_c04660	COG0470	DNA polymerase III
Tph_c04670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tph_c04690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tph_c04740	COG1414	Transcriptional regulator
Tph_c04760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tph_c04780	COG3426	butyrate kinase activity
Tph_c04790	COG0280	phosphate acetyltransferase
Tph_c04830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tph_c04840	COG0745	RESPONSE REGULATOR receiver
Tph_c04850	COG5002	protein histidine kinase activity
Tph_c04860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tph_c04870	COG0704	Plays a role in the regulation of phosphate uptake
Tph_c04880	COG0573	inorganic phosphate transmembrane transporter activity
Tph_c04890	COG0581	inorganic phosphate transmembrane transporter activity
Tph_c04910	COG0525	valine-tRNA ligase activity
Tph_c04920	COG1045	serine acetyltransferase
Tph_c04930	COG0215	cysteine-tRNA ligase activity
Tph_c04950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tph_c04960	COG3688	RNA-binding protein containing a PIN domain
Tph_c05040	COG0835	chemotaxis
Tph_c05050	COG2201	protein-glutamate methylesterase activity
Tph_c05070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tph_c05080	COG0745	RESPONSE REGULATOR receiver
Tph_c05090	COG0643	Histidine kinase
Tph_c05090	COG2198	Histidine kinase
Tph_c05130	COG0840	transmembrane signaling receptor activity
Tph_c05140	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Tph_c05160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tph_c05180	COG0310	cobalt ion transport
Tph_c05190	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
Tph_c05210	COG1122	ATPase activity
Tph_c05220	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Tph_c05280	COG2099	Precorrin-6x reductase
Tph_c05300	COG1492	cobalamin metabolic process
Tph_c05320	COG1980	fructose-bisphosphate aldolase activity
Tph_c05330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tph_c05390	COG2323	membrane
Tph_c05400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tph_c05490	COG2197	response regulator
Tph_c05540	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
Tph_c05550	COG1040	competence protein
Tph_c05590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Tph_c05600	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tph_c05670	COG4786	Flagellar basal body rod
Tph_c05670	COG1256	bacterial-type flagellum assembly
Tph_c05700	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Tph_c05710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Tph_c05720	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tph_c05730	COG1151	hydroxylamine reductase activity
Tph_c05740	COG1381	Involved in DNA repair and RecF pathway recombination
Tph_c05760	COG0752	glycyl-tRNA synthetase alpha subunit
Tph_c05770	COG0751	glycine-tRNA ligase activity
Tph_c05780	COG0517	IMP dehydrogenase activity
Tph_c05790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tph_c05800	COG0574	Belongs to the PEP-utilizing enzyme family
Tph_c05800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tph_c05830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tph_c05840	COG0358	DNA primase activity
Tph_c05850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tph_c05860	COG5012	cobalamin binding
Tph_c05920	COG0285	dihydrofolate synthase activity
Tph_c05930	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Tph_c05950	COG0424	maF-like protein
Tph_c05960	COG2003	Belongs to the UPF0758 family
Tph_c05970	COG1077	Cell shape determining protein MreB Mrl
Tph_c05980	COG1792	Involved in formation and maintenance of cell shape
Tph_c06010	COG0850	regulation of cytokinetic process
Tph_c06020	COG2894	cell division
Tph_c06030	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tph_c06040	COG0772	Belongs to the SEDS family
Tph_c06080	COG1530	ribonuclease E activity
Tph_c06090	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Tph_c06130	COG0393	Putative heavy-metal-binding
Tph_c06170	COG1595	DNA-templated transcription, initiation
Tph_c06330	COG4372	Transposase
Tph_c06390	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tph_c06400	COG1342	Belongs to the UPF0251 family
Tph_c06440	COG1283	sodium-dependent phosphate transmembrane transporter activity
Tph_c06460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Tph_c06470	COG0653	protein targeting
Tph_c06490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Tph_c06500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Tph_c06510	COG3959	Transketolase, thiamine diphosphate binding domain
Tph_c06520	COG3958	Transketolase
Tph_c06530	COG2884	Cell division ATP-binding protein ftsE
Tph_c06540	COG2177	Part of the ABC transporter FtsEX involved in
Tph_c06550	COG0739	heme binding
Tph_c06580	COG0793	Belongs to the peptidase S41A family
Tph_c06580	COG3409	Peptidoglycan-binding domain 1 protein
Tph_c06590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tph_c06630	COG0556	nucleotide-excision repair
Tph_c06640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tph_c06650	COG0322	excinuclease ABC activity
Tph_c06660	COG0561	phosphatase activity
Tph_c06670	COG0166	Belongs to the GPI family
Tph_c06680	COG1940	carbohydrate kinase activity
Tph_c06690	COG1660	Displays ATPase and GTPase activities
Tph_c06700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Tph_c06710	COG1481	regulation of sporulation
Tph_c06730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tph_c06750	COG0126	phosphoglycerate kinase activity
Tph_c06760	COG0149	triose-phosphate isomerase activity
Tph_c06770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Tph_c06780	COG0148	phosphopyruvate hydratase activity
Tph_c06790	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tph_c06820	COG5012	cobalamin binding
Tph_c06870	COG4810	utilization protein
Tph_c06900	COG4917	ethanolamine utilization protein
Tph_c06940	COG4303	Ethanolamine ammonia lyase large subunit
Tph_c06950	COG4302	ethanolamine ammonia-lyase activity
Tph_c06960	COG4816	utilization protein
Tph_c06970	COG1454	alcohol dehydrogenase
Tph_c06970	COG1012	belongs to the aldehyde dehydrogenase family
Tph_c06980	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Tph_c06990	COG4812	Cobalamin adenosyltransferase
Tph_c07000	COG4820	ethanolamine utilization protein (EutJ)
Tph_c07020	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Tph_c07030	COG4656	Part of a membrane complex involved in electron transport
Tph_c07040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Tph_c07060	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Tph_c07070	COG3192	ethanolamine utilization protein
Tph_c07090	COG1396	sequence-specific DNA binding
Tph_c07140	COG0557	exoribonuclease II activity
Tph_c07150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tph_c07250	COG2088	sporulation resulting in formation of a cellular spore
Tph_c07290	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tph_c07320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tph_c07390	COG4974	Belongs to the 'phage' integrase family
Tph_c07520	COG0739	heme binding
Tph_c07660	COG2033	superoxide reductase activity
Tph_c07720	COG2801	Transposase and inactivated derivatives
Tph_c07780	COG3706	GGDEF domain
Tph_c07850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tph_c07980	COG2361	Protein of unknown function DUF86
Tph_c07990	COG1773	rubredoxin
Tph_c07990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tph_c08000	COG2033	superoxide reductase activity
Tph_c08020	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tph_c08030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tph_c08080	COG1793	dna ligase
Tph_c08080	COG3285	dna ligase
Tph_c08100	COG3942	CHAP domain
Tph_c08100	COG1388	LysM domain
Tph_c08130	COG1316	TRANSCRIPTIONal
Tph_c08150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Tph_c08160	COG0438	transferase activity, transferring glycosyl groups
Tph_c08170	COG0741	lytic transglycosylase activity
Tph_c08180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tph_c08190	COG3852	Histidine kinase
Tph_c08200	COG2204	response regulator
Tph_c08220	COG2414	aldehyde ferredoxin oxidoreductase
Tph_c08280	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Tph_c08290	COG1606	tRNA processing
Tph_c08320	COG1910	domain protein
Tph_c08330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tph_c08340	COG0315	cyclic pyranopterin monophosphate synthase activity
Tph_c08360	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tph_c08370	COG0459	protein refolding
Tph_c08390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tph_c08410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tph_c08410	COG0519	Catalyzes the synthesis of GMP from XMP
Tph_c08420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tph_c08430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tph_c08440	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tph_c08450	COG0047	phosphoribosylformylglycinamidine synthase activity
Tph_c08460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tph_c08470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Tph_c08480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tph_c08490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tph_c08500	COG0138	bifunctional purine biosynthesis protein purh
Tph_c08540	COG3707	response regulator
Tph_c08550	COG0067	glutamate synthase
Tph_c08560	COG0069	glutamate synthase activity
Tph_c08570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tph_c08570	COG0493	'glutamate synthase
Tph_c08600	COG1797	cobyrinic acid a,c-diamide synthase activity
Tph_c08610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tph_c08610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tph_c08630	COG0367	asparagine synthase
Tph_c08660	COG0347	Belongs to the P(II) protein family
Tph_c08670	COG0347	Belongs to the P(II) protein family
Tph_c08720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tph_c08730	COG3842	ATPase activity
Tph_c08750	COG0004	ammonium transporteR
Tph_c08760	COG0347	Belongs to the P(II) protein family
Tph_c08770	COG0697	spore germination
Tph_c08780	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Tph_c08810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Tph_c08820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tph_c08830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tph_c08840	COG0131	Imidazoleglycerol-phosphate dehydratase
Tph_c08850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tph_c08860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tph_c08870	COG0107	imidazoleglycerol-phosphate synthase activity
Tph_c08880	COG0140	phosphoribosyl-ATP diphosphatase activity
Tph_c08880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tph_c08910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tph_c08930	COG0516	GMP reductase activity
Tph_c08930	COG0517	IMP dehydrogenase activity
Tph_c08960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tph_c08970	COG0154	amidase activity
Tph_c08980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tph_c09000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tph_c09010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tph_c09020	COG0066	3-isopropylmalate dehydratase activity
Tph_c09030	COG0473	3-isopropylmalate dehydrogenase activity
Tph_c09060	COG0697	spore germination
Tph_c09090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tph_c09100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tph_c09120	COG5012	cobalamin binding
Tph_c09130	COG1151	hydroxylamine reductase activity
Tph_c09140	COG1959	2 iron, 2 sulfur cluster binding
Tph_c09150	COG1543	Belongs to the glycosyl hydrolase 57 family
Tph_c09180	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tph_c09190	COG0298	carbon dioxide binding
Tph_c09200	COG0409	Hydrogenase expression formation protein
Tph_c09270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tph_c09300	COG1968	undecaprenyl-diphosphatase activity
Tph_c09310	COG3464	Transposase
Tph_c09380	COG0205	6-phosphofructokinase activity
Tph_c09410	COG0719	Fe-S assembly protein
Tph_c09470	COG0310	cobalt ion transport
Tph_c09490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tph_c09510	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tph_c09520	COG0287	Prephenate dehydrogenase
Tph_c09570	COG1073	alpha beta
Tph_c09600	COG1882	Formate acetyltransferase
Tph_c09690	COG3290	protein histidine kinase activity
Tph_c09690	COG0840	transmembrane signaling receptor activity
Tph_c09770	COG3679	Belongs to the UPF0342 family
Tph_c09780	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tph_c09790	COG1122	ATPase activity
Tph_c09810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tph_c09820	COG0010	Belongs to the arginase family
Tph_c09960	COG1302	Protein conserved in bacteria
Tph_c09980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tph_c10010	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Tph_c10020	COG1573	uracil-dna glycosylase
Tph_c10030	COG3464	Transposase
Tph_c10040	COG0742	ribosomal rna small subunit methyltransferase
Tph_c10050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tph_c10070	COG3314	Sporulation integral membrane protein YlbJ
Tph_c10080	COG0280	phosphate acetyltransferase
Tph_c10090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tph_c10110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tph_c10120	COG0416	fatty acid biosynthetic process
Tph_c10130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tph_c10140	COG0571	ribonuclease III activity
Tph_c10150	COG2359	stage V sporulation protein S
Tph_c10160	COG1196	nuclear chromosome segregation
Tph_c10170	COG0552	protein localization to endoplasmic reticulum
Tph_c10180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tph_c10190	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tph_c10200	COG0235	Class ii aldolase
Tph_c10210	COG0402	S-adenosylhomocysteine deaminase activity
Tph_c10220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tph_c10230	COG0228	four-way junction DNA binding
Tph_c10250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tph_c10260	COG0336	Belongs to the RNA methyltransferase TrmD family
Tph_c10270	COG0335	large ribosomal subunit rRNA binding
Tph_c10290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Tph_c10300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tph_c10320	COG2257	FlhB HrpN YscU SpaS Family
Tph_c10340	COG0792	nuclease activity
Tph_c10350	COG0277	FAD linked oxidase domain protein
Tph_c10360	COG0247	lactate metabolic process
Tph_c10410	COG0560	Phosphoserine phosphatase
Tph_c10450	COG3344	reverse transcriptase
Tph_c10590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tph_c10670	COG1725	Transcriptional regulator
Tph_c10680	COG1131	(ABC) transporter
Tph_c10700	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Tph_c10710	COG0758	DNA mediated transformation
Tph_c10720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tph_c10730	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Tph_c10740	COG4974	Belongs to the 'phage' integrase family
Tph_c10750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tph_c10760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tph_c10790	COG1815	bacterial-type flagellum-dependent cell motility
Tph_c10800	COG1558	bacterial-type flagellum-dependent cell motility
Tph_c10810	COG1677	Flagellar hook-basal body complex protein FliE
Tph_c10820	COG1766	The M ring may be actively involved in energy transduction
Tph_c10830	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tph_c10850	COG1157	protein secretion by the type III secretion system
Tph_c10890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tph_c10940	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tph_c10950	COG1776	CheC inhibitor of MCP methylation
Tph_c10950	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tph_c10960	COG2201	protein-glutamate methylesterase activity
Tph_c10980	COG1338	Plays a role in the flagellum-specific transport system
Tph_c10990	COG1987	bacterial-type flagellum assembly
Tph_c11000	COG1684	flagellar biosynthetic protein fliR
Tph_c11010	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tph_c11020	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tph_c11030	COG1419	protein localization to endoplasmic reticulum
Tph_c11040	COG0455	bacterial-type flagellum organization
Tph_c11060	COG2201	protein-glutamate methylesterase activity
Tph_c11070	COG2198	Histidine kinase
Tph_c11070	COG0643	Histidine kinase
Tph_c11080	COG1776	CheC inhibitor of MCP methylation
Tph_c11090	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tph_c11100	COG1191	sigma factor activity
Tph_c11140	COG0052	Belongs to the universal ribosomal protein uS2 family
Tph_c11150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tph_c11160	COG0528	UMP kinase activity
Tph_c11170	COG0233	cytoplasmic translational termination
Tph_c11210	COG4589	Belongs to the CDS family
Tph_c11220	COG0628	permease
Tph_c11230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tph_c11240	COG0750	zinc metalloprotease
Tph_c11250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tph_c11260	COG0442	prolyl-tRNA aminoacylation
Tph_c11270	COG0779	Required for maturation of 30S ribosomal subunits
Tph_c11280	COG0195	Participates in both transcription termination and antitermination
Tph_c11290	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Tph_c11310	COG3064	Membrane
Tph_c11310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tph_c11310	COG3064	Membrane
Tph_c11310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tph_c11320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tph_c11330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Tph_c11340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tph_c11350	COG0196	riboflavin kinase activity
Tph_c11360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tph_c11370	COG1185	polyribonucleotide nucleotidyltransferase activity
Tph_c11380	COG0726	polysaccharide deacetylase
Tph_c11400	COG0612	Peptidase, M16
Tph_c11410	COG1873	PFAM PRC-barrel domain
Tph_c11430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tph_c11440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tph_c11450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Tph_c11460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tph_c11470	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tph_c11490	COG0740	serine-type endopeptidase activity
Tph_c11500	COG1674	ftsk spoiiie
Tph_c11510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tph_c11510	COG1522	sequence-specific DNA binding
Tph_c11520	COG1426	Protein conserved in bacteria
Tph_c11530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tph_c11550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tph_c11560	COG1058	Belongs to the CinA family
Tph_c11560	COG1546	Belongs to the CinA family
Tph_c11580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tph_c11590	COG1418	mRNA catabolic process
Tph_c11610	COG1692	metallophosphoesterase
Tph_c11620	COG2359	stage V sporulation protein S
Tph_c11650	COG0791	NLP P60 protein
Tph_c11690	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Tph_c11700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Tph_c11710	COG0406	alpha-ribazole phosphatase activity
Tph_c11720	COG0516	GMP reductase activity
Tph_c11720	COG0517	IMP dehydrogenase activity
Tph_c11730	COG0542	response to heat
Tph_c11750	COG1285	pathogenesis
Tph_c11760	COG3344	reverse transcriptase
Tph_c11790	COG0297	glycogen (starch) synthase activity
Tph_c11800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tph_c12040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tph_c12210	COG1192	Involved in chromosome partitioning
Tph_c12240	COG3547	Transposase (IS116 IS110 IS902 family)
Tph_c12270	COG1131	(ABC) transporter
Tph_c12300	COG0632	four-way junction helicase activity
Tph_c12320	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tph_c12350	COG2247	cell wall binding repeat
Tph_c12350	COG2385	sporulation resulting in formation of a cellular spore
Tph_c12370	COG0343	queuine tRNA-ribosyltransferase activity
Tph_c12390	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tph_c12410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tph_c12420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tph_c12430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tph_c12440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tph_c12460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tph_c12470	COG1490	D-aminoacyl-tRNA deacylase activity
Tph_c12480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tph_c12490	COG0124	histidyl-tRNA synthetase
Tph_c12500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tph_c12510	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Tph_c12530	COG2234	aminopeptidase activity
Tph_c12550	COG2001	Belongs to the MraZ family
Tph_c12560	COG0275	rRNA processing
Tph_c12580	COG0768	penicillin binding
Tph_c12590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tph_c12600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tph_c12610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tph_c12620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tph_c12630	COG0772	Belongs to the SEDS family
Tph_c12640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tph_c12650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tph_c12660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tph_c12670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tph_c12680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tph_c12700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tph_c12720	COG1191	sigma factor activity
Tph_c12730	COG1191	sigma factor activity
Tph_c12750	COG1873	PFAM PRC-barrel domain
Tph_c12760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tph_c12780	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Tph_c12810	COG2608	mercury ion transmembrane transporter activity
Tph_c12830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Tph_c12840	COG1799	cell septum assembly
Tph_c12850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tph_c12860	COG0762	integral membrane protein
Tph_c12870	COG1872	DUF167
Tph_c12900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tph_c12910	COG3830	Belongs to the UPF0237 family
Tph_c12920	COG2848	UPF0210 protein
Tph_c12950	COG0438	transferase activity, transferring glycosyl groups
Tph_c12960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tph_c12970	COG0564	pseudouridine synthase activity
Tph_c12980	COG0174	glutamine synthetase
Tph_c13030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tph_c13040	COG0037	tRNA processing
Tph_c13050	COG3191	aminopeptidase activity
Tph_c13150	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tph_c13180	COG0037	tRNA processing
Tph_c13230	COG2249	NAD(P)H dehydrogenase (quinone) activity
Tph_c13250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tph_c13250	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Tph_c13300	COG0730	response to heat
Tph_c13310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tph_c13320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tph_c13330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tph_c13340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tph_c13350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tph_c13360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tph_c13360	COG0072	phenylalanine-tRNA ligase activity
Tph_c13370	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Tph_c13380	COG1796	DNA polymerase
Tph_c13380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Tph_c13400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tph_c13410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tph_c13420	COG1993	acr, cog1993
Tph_c13440	COG1193	negative regulation of DNA recombination
Tph_c13450	COG2135	peptidase activity
Tph_c13460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tph_c13460	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tph_c13500	COG0432	Pfam Uncharacterised protein family UPF0047
Tph_c13510	COG0432	Pfam Uncharacterised protein family UPF0047
Tph_c13540	COG1376	ErfK ybiS ycfS ynhG family protein
Tph_c13610	COG1053	succinate dehydrogenase
Tph_c13620	COG3547	Transposase (IS116 IS110 IS902 family)
Tph_c13670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tph_c13690	COG0825	malonyl-CoA metabolic process
Tph_c13700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Tph_c13710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tph_c13720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tph_c13730	COG1028	Short-chain dehydrogenase reductase Sdr
Tph_c13740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tph_c13760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tph_c13780	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Tph_c13790	COG0464	growth
Tph_c13800	COG1174	glycine betaine transport
Tph_c13810	COG1116	anion transmembrane transporter activity
Tph_c13820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tph_c13820	COG1116	anion transmembrane transporter activity
Tph_c13830	COG3328	transposase activity
Tph_c13840	COG1923	regulation of RNA biosynthetic process
Tph_c13850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tph_c13860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tph_c13890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tph_c13910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tph_c14000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tph_c14010	COG0622	Phosphoesterase
Tph_c14020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tph_c14030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tph_c14030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tph_c14040	COG0307	riboflavin synthase, alpha
Tph_c14050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tph_c14050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tph_c14210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tph_c14220	COG1162	GTPase activity
Tph_c14230	COG2815	serine threonine protein kinase
Tph_c14230	COG0515	serine threonine protein kinase
Tph_c14250	COG0772	Belongs to the SEDS family
Tph_c14270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tph_c14270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tph_c14280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tph_c14290	COG0242	peptide deformylase activity
Tph_c14300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tph_c14310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tph_c14320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tph_c14330	COG1758	RNA polymerase activity
Tph_c14340	COG0194	GDP metabolic process
Tph_c14350	COG2052	Domain of unknown function (DUF370)
Tph_c14360	COG1561	YicC-like family, N-terminal region
Tph_c14370	COG0436	Aminotransferase
Tph_c14380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tph_c14410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tph_c14420	COG0284	orotidine-5'-phosphate decarboxylase activity
Tph_c14430	COG0167	dihydroorotate dehydrogenase activity
Tph_c14440	COG0543	2 iron, 2 sulfur cluster binding
Tph_c14450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tph_c14460	COG0505	Belongs to the CarA family
Tph_c14470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tph_c14480	COG0540	Belongs to the ATCase OTCase family
Tph_c14490	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tph_c14520	COG2217	Heavy metal translocating P-type atpase
Tph_c14690	COG3279	Response regulator of the LytR AlgR family
Tph_c14710	COG3290	protein histidine kinase activity
Tph_c14850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tph_c14920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tph_c14930	COG0302	gtp cyclohydrolase
Tph_c14950	COG0735	belongs to the Fur family
Tph_c14960	COG0745	RESPONSE REGULATOR receiver
Tph_c15020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tph_c15030	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tph_c15040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tph_c15050	COG3935	DnaD domain protein
Tph_c15070	COG0436	Aminotransferase
Tph_c15200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tph_c15210	COG1307	EDD domain protein, DegV family
Tph_c15260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tph_c15270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tph_c15300	COG0113	porphobilinogen synthase activity
Tph_c15330	COG0181	hydroxymethylbilane synthase activity
Tph_c15340	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tph_c15350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tph_c15350	COG1648	precorrin-2 dehydrogenase activity
Tph_c15390	COG0437	4 iron, 4 sulfur cluster binding
Tph_c15420	COG0805	protein transport
Tph_c15440	COG0163	prenyltransferase activity
Tph_c15450	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tph_c15470	COG2048	Heterodisulfide reductase, subunit B
Tph_c15490	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Tph_c15540	COG0083	homoserine kinase activity
Tph_c15550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tph_c15560	COG0460	homoserine dehydrogenase
Tph_c15570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Tph_c15580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tph_c15590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tph_c15690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tph_c15690	COG0539	negative regulation of cytoplasmic translation
Tph_c15710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tph_c15720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tph_c15730	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tph_c15740	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
Tph_c15790	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Tph_c15800	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Tph_c15810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tph_c15820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tph_c15830	COG1187	pseudouridine synthase activity
Tph_c15850	COG0700	Nucleoside recognition
Tph_c15860	COG2715	membrane protein required for spore maturation
Tph_c15870	COG1686	Belongs to the peptidase S11 family
Tph_c15880	COG3874	Sporulation protein YtfJ
Tph_c15900	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tph_c15920	COG0180	Tryptophanyl-tRNA synthetase
Tph_c15930	COG1994	Peptidase M50
Tph_c15940	COG0019	diaminopimelate decarboxylase activity
Tph_c15950	COG1924	4 iron, 4 sulfur cluster binding
Tph_c15990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tph_c16020	COG1191	sigma factor activity
Tph_c16030	COG2172	sigma factor antagonist activity
Tph_c16040	COG1366	Belongs to the anti-sigma-factor antagonist family
Tph_c16050	COG1686	Belongs to the peptidase S11 family
Tph_c16070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Tph_c16080	COG4974	Belongs to the 'phage' integrase family
Tph_c16100	COG1300	Membrane
Tph_c16120	COG1379	DNA repair
Tph_c16150	COG2195	Cleaves the N-terminal amino acid of tripeptides
Tph_c16160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tph_c16170	COG0463	Glycosyl transferase, family 2
Tph_c16200	COG0745	RESPONSE REGULATOR receiver
Tph_c16210	COG0750	zinc metalloprotease
Tph_c16220	COG0497	DNA recombination
Tph_c16230	COG1438	arginine binding
Tph_c16240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tph_c16250	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tph_c16260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tph_c16300	COG1570	exodeoxyribonuclease VII activity
Tph_c16310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tph_c16320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tph_c16330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tph_c16360	COG1302	Protein conserved in bacteria
Tph_c16370	COG0439	Biotin carboxylase
Tph_c16460	COG3854	ATPases associated with a variety of cellular activities
Tph_c16480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tph_c16490	COG0006	proline dipeptidase activity
Tph_c16500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tph_c16510	COG0312	modulator of DNA gyrase
Tph_c16520	COG0312	modulator of DNA gyrase
Tph_c16540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tph_c16570	COG0849	cell division
Tph_c16620	COG2165	general secretion pathway protein
Tph_c16670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tph_c16680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tph_c16690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tph_c16700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tph_c16720	COG2201	protein-glutamate methylesterase activity
Tph_c16730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Tph_c16790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tph_c16860	COG0768	penicillin binding
Tph_c16880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tph_c16890	COG2720	vancomycin resistance protein
Tph_c16900	COG3906	Belongs to the UPF0473 family
Tph_c16910	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tph_c16920	COG0667	Aldo Keto reductase
Tph_c16930	COG4472	Bacterial protein of unknown function (DUF965)
Tph_c16940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tph_c16970	COG0433	COG0433 Predicted ATPase
Tph_c16990	COG0515	serine threonine protein kinase
Tph_c16990	COG2815	serine threonine protein kinase
Tph_c17030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tph_c17060	COG0778	Nitroreductase
Tph_c17070	COG4608	Belongs to the ABC transporter superfamily
Tph_c17080	COG0444	Belongs to the ABC transporter superfamily
Tph_c17090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tph_c17100	COG0601	transmembrane transport
Tph_c17110	COG0747	negative chemotaxis
Tph_c17140	COG1760	l-serine dehydratase
Tph_c17150	COG1760	l-serine dehydratase
Tph_c17160	COG4475	Protein of unknown function (DUF436)
Tph_c17170	COG0095	Lipoate-protein ligase
Tph_c17180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tph_c17190	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tph_c17200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tph_c17210	COG0509	glycine decarboxylation via glycine cleavage system
Tph_c17220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tph_c17250	COG0628	permease
Tph_c17290	COG0482	sulfurtransferase activity
Tph_c17300	COG1104	cysteine desulfurase activity
Tph_c17320	COG3118	belongs to the thioredoxin family
Tph_c17340	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Tph_c17360	COG0445	tRNA wobble uridine modification
Tph_c17390	COG3290	protein histidine kinase activity
Tph_c17410	COG3279	Response regulator of the LytR AlgR family
Tph_c17480	COG3328	transposase activity
Tph_c17640	COG3464	Transposase
Tph_c17650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tph_c17700	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tph_c17780	COG0352	thiamine-phosphate diphosphorylase activity
Tph_c17790	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Tph_c17810	COG0351	phosphomethylpyrimidine kinase
Tph_c17810	COG0352	thiamine-phosphate diphosphorylase activity
Tph_c17830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tph_c17840	COG0352	thiamine-phosphate diphosphorylase activity
Tph_c17860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tph_c17870	COG2022	thiamine diphosphate biosynthetic process
Tph_c17900	COG2223	nitrite transmembrane transporter activity
Tph_c17930	COG0601	transmembrane transport
Tph_c17940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tph_c17960	COG1104	cysteine desulfurase activity
Tph_c17980	COG0798	PFAM Bile acid sodium symporter
Tph_c18030	COG4166	transmembrane transport
Tph_c18050	COG0739	heme binding
Tph_c18050	COG1196	nuclear chromosome segregation
Tph_c18050	COG0741	lytic transglycosylase activity
Tph_c18060	COG0237	dephospho-CoA kinase activity
Tph_c18080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tph_c18100	COG2843	Capsule synthesis protein
Tph_c18120	COG0217	transcriptional regulatory protein
Tph_c18130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tph_c18180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tph_c18210	COG1335	isochorismatase
Tph_c18270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tph_c18320	COG4120	Belongs to the binding-protein-dependent transport system permease family
Tph_c18360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tph_c18370	COG2384	SAM-dependent methyltransferase
Tph_c18380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tph_c18420	COG3383	formate dehydrogenase (NAD+) activity
Tph_c18470	COG3409	Peptidoglycan-binding domain 1 protein
Tph_c18470	COG3773	Cell wall hydrolase
Tph_c18500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tph_c18530	COG0456	acetyltransferase
Tph_c18540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tph_c18550	COG0802	atpase or kinase
Tph_c18560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tph_c18570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tph_c18570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tph_c18580	COG0736	holo-[acyl-carrier-protein] synthase activity
Tph_c18600	COG0835	chemotaxis
Tph_c18610	COG0012	GTP binding
Tph_c18620	COG0667	Aldo Keto reductase
Tph_c18630	COG1115	amino acid carrier protein
Tph_c18650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tph_c18660	COG1307	EDD domain protein, DegV family
Tph_c18670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tph_c18680	COG0546	phosphoglycolate phosphatase activity
Tph_c18690	COG1757	Na H antiporter
Tph_c18730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tph_c18780	COG1924	4 iron, 4 sulfur cluster binding
Tph_c18810	COG1309	transcriptional regulator
Tph_c18850	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Tph_c18860	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Tph_c18900	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Tph_c18970	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tph_c19080	COG0318	PFAM AMP-dependent synthetase and ligase
Tph_c19110	COG1132	(ABC) transporter
Tph_c19120	COG1132	(ABC) transporter
Tph_c19130	COG1846	Transcriptional regulator
Tph_c19140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tph_c19160	COG0640	Transcriptional regulator
Tph_c19200	COG1104	cysteine desulfurase activity
Tph_c19210	COG0822	iron-sulfur transferase activity
Tph_c19230	COG0425	Belongs to the sulfur carrier protein TusA family
Tph_c19410	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tph_c19510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tph_c19580	COG0247	lactate metabolic process
Tph_c19600	COG0509	glycine decarboxylation via glycine cleavage system
Tph_c19620	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tph_c19630	COG3199	ATP-NAD kinase
Tph_c19640	COG0022	dehydrogenase e1 component
Tph_c19650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tph_c19660	COG1063	alcohol dehydrogenase
Tph_c19670	COG3328	transposase activity
Tph_c19720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tph_c19730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tph_c19780	COG3856	small basic protein
Tph_c19800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tph_c19810	COG0473	3-isopropylmalate dehydrogenase activity
Tph_c19820	COG0066	3-isopropylmalate dehydratase activity
Tph_c19830	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tph_c19840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tph_c19850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tph_c19860	COG0440	acetolactate synthase activity
Tph_c19870	COG0028	Belongs to the TPP enzyme family
Tph_c19880	COG0129	dihydroxy-acid dehydratase activity
Tph_c19890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tph_c19910	COG1773	rubredoxin
Tph_c19910	COG1592	Rubrerythrin
Tph_c19940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tph_c20010	COG3464	Transposase
Tph_c20110	COG3547	Transposase (IS116 IS110 IS902 family)
Tph_c20130	COG5012	cobalamin binding
Tph_c20150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Tph_c20170	COG1732	Glycine betaine
Tph_c20180	COG0517	IMP dehydrogenase activity
Tph_c20180	COG1125	glycine betaine transport
Tph_c20190	COG1174	glycine betaine transport
Tph_c20200	COG0438	transferase activity, transferring glycosyl groups
Tph_c20250	COG3799	methylaspartate ammonia-lyase activity
Tph_c20260	COG4865	methylaspartate mutase activity
Tph_c20280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tph_c20290	COG5012	cobalamin binding
Tph_c20330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tph_c20340	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Tph_c20350	COG2414	aldehyde ferredoxin oxidoreductase
Tph_c20390	COG1174	glycine betaine transport
Tph_c20420	COG3829	transcription factor binding
Tph_c20430	COG3404	Formiminotransferase-cyclodeaminase
Tph_c20450	COG1228	amidohydrolase
Tph_c20460	COG2986	histidine ammonia-lyase
Tph_c20470	COG0577	efflux transmembrane transporter activity
Tph_c20480	COG4591	ABC-type transport system involved in lipoprotein release permease component
Tph_c20480	COG1136	(ABC) transporter
Tph_c20510	COG0492	ferredoxin-NADP+ reductase activity
Tph_c20540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tph_c20550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Tph_c20560	COG0512	Glutamine amidotransferase of anthranilate synthase
Tph_c20570	COG1959	2 iron, 2 sulfur cluster binding
Tph_c20580	COG1104	cysteine desulfurase activity
Tph_c20610	COG2207	Transcriptional regulator
Tph_c20610	COG4753	response regulator
Tph_c20620	COG0326	Molecular chaperone. Has ATPase activity
Tph_c20640	COG2972	Histidine kinase
Tph_c20650	COG1937	Protein conserved in bacteria
Tph_c20670	COG2217	Heavy metal translocating P-type atpase
Tph_c20790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tph_c20790	COG1213	nucleotidyl transferase
Tph_c20800	COG1260	myo-inositol-1-phosphate synthase
Tph_c20820	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tph_c20830	COG2336	PFAM SpoVT AbrB
Tph_c20850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tph_c20900	COG3546	catalase activity
Tph_c20950	COG1595	DNA-templated transcription, initiation
Tph_c21000	COG2076	Multidrug Resistance protein
Tph_c21010	COG1268	BioY protein
Tph_c21020	COG1122	ATPase activity
Tph_c21030	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tph_c21060	COG0537	adenosine 5'-monophosphoramidase activity
Tph_c21080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tph_c21090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tph_c21110	COG0443	Heat shock 70 kDa protein
Tph_c21120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tph_c21130	COG1420	regulation of RNA biosynthetic process
Tph_c21140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tph_c21150	COG0481	GTPase activity
Tph_c21160	COG0728	peptidoglycan biosynthetic process
Tph_c21230	COG0363	glucosamine-6-phosphate deaminase activity
Tph_c21240	COG0268	Binds directly to 16S ribosomal RNA
Tph_c21280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tph_c21290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tph_c21300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tph_c21340	COG3260	NADH ubiquinone oxidoreductase 20
Tph_c21360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tph_c21360	COG2111	Na H antiporter
Tph_c21380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tph_c21390	COG0495	leucyl-tRNA aminoacylation
Tph_c21410	COG1305	Transglutaminase-like
Tph_c21500	COG2197	response regulator
Tph_c21520	COG0799	negative regulation of ribosome biogenesis
Tph_c21530	COG1713	HD superfamily hydrolase involved in NAD metabolism
Tph_c21540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tph_c21550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tph_c21560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tph_c21570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tph_c21580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tph_c21600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tph_c21650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tph_c21660	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tph_c21690	COG0789	Transcriptional regulator
Tph_c21720	COG0656	L-ascorbic acid biosynthetic process
Tph_c21730	COG1979	alcohol dehydrogenase
Tph_c21840	COG2814	Major facilitator Superfamily
Tph_c21880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Tph_c21890	COG4372	Transposase
Tph_c21970	COG0582	viral genome integration into host DNA
Tph_c22050	COG3328	transposase activity
Tph_c22100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tph_c22110	COG0765	amino acid transport
Tph_c22120	COG1126	abc transporter atp-binding protein
Tph_c22150	COG1516	flagellar protein fliS
Tph_c22170	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tph_c22190	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tph_c22270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tph_c22280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tph_c22290	COG2959	enzyme of heme biosynthesis
Tph_c22300	COG3773	Cell wall hydrolase
Tph_c22300	COG3409	Peptidoglycan-binding domain 1 protein
Tph_c22310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Tph_c22330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tph_c22340	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tph_c22360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tph_c22400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tph_c22410	COG1121	(ABC) transporter
Tph_c22420	COG3443	Belongs to the bacterial solute-binding protein 9 family
Tph_c22420	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tph_c22430	COG0735	belongs to the Fur family
Tph_c22440	COG1811	Na channel or pump
Tph_c22460	COG3290	protein histidine kinase activity
Tph_c22510	COG0489	protein tyrosine kinase activity
Tph_c22580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tph_c22610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tph_c22610	COG0731	radical SAM domain protein
Tph_c22620	COG1464	Belongs to the NlpA lipoprotein family
Tph_c22630	COG2011	ABC-type metal ion transport system permease component
Tph_c22640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Tph_c22670	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Tph_c22690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tph_c22700	COG0295	cytidine deaminase activity
Tph_c22710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Tph_c22720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tph_c22730	COG1480	7TM receptor with intracellular HD hydrolase
Tph_c22740	COG1702	phosphate starvation-inducible protein PhoH
Tph_c22780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tph_c22830	COG0617	tRNA 3'-terminal CCA addition
Tph_c22850	COG2333	competence protein COMEC
Tph_c22850	COG0658	competence protein
Tph_c22920	COG0310	cobalt ion transport
Tph_c22970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tph_c23010	COG3409	Peptidoglycan-binding domain 1 protein
Tph_c23010	COG5632	N-Acetylmuramoyl-L-alanine amidase
Tph_c23030	COG0726	polysaccharide deacetylase
Tph_c23150	COG0740	serine-type endopeptidase activity
Tph_c23160	COG4695	Portal protein
Tph_c23180	COG1802	Transcriptional regulator
Tph_c23180	COG4626	Terminase
Tph_c23380	COG1592	Rubrerythrin
Tph_c23460	COG0822	iron-sulfur transferase activity
Tph_c23470	COG1342	Belongs to the UPF0251 family
Tph_c23550	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Tph_c23580	COG0577	efflux transmembrane transporter activity
Tph_c23580	COG1136	(ABC) transporter
Tph_c23590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tph_c23600	COG1136	(ABC) transporter
Tph_c23630	COG0745	RESPONSE REGULATOR receiver
Tph_c23640	COG2770	Histidine kinase
Tph_c23640	COG2205	protein histidine kinase activity
Tph_c23670	COG1136	(ABC) transporter
Tph_c23770	COG1690	Belongs to the RtcB family
Tph_c23800	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Tph_c23830	COG1304	FMN binding
Tph_c23890	COG0697	spore germination
Tph_c23920	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tph_c23930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tph_c23940	COG0167	dihydroorotate dehydrogenase activity
Tph_c23950	COG1802	Transcriptional regulator
Tph_c23980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tph_c23980	COG0473	3-isopropylmalate dehydrogenase activity
Tph_c23990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tph_c24000	COG0473	3-isopropylmalate dehydrogenase activity
Tph_c24000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tph_c24010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tph_c24020	COG0167	dihydroorotate dehydrogenase activity
Tph_c24060	COG2508	Transcriptional regulator
Tph_c24060	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Tph_c24070	COG3976	FMN-binding domain protein
Tph_c24070	COG1053	succinate dehydrogenase
Tph_c24070	COG0431	NADPH-dependent FMN reductase
Tph_c24080	COG2155	Conserved Protein
Tph_c24120	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tph_c24210	COG3547	Transposase (IS116 IS110 IS902 family)
Tph_c24250	COG3547	Transposase (IS116 IS110 IS902 family)
Tph_c24270	COG4372	Transposase
Tph_c24380	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tph_c24390	COG1518	maintenance of DNA repeat elements
Tph_c24490	COG1337	RAMP superfamily
Tph_c24540	COG1337	RAMP superfamily
Tph_c24630	COG0328	RNA-DNA hybrid ribonuclease activity
Tph_c24660	COG2323	membrane
Tph_c24690	COG2252	PERMEase
Tph_c24760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tph_c24800	COG0842	Transport permease protein
Tph_c24810	COG1131	(ABC) transporter
Tph_c24820	COG1131	(ABC) transporter
Tph_c24830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tph_c24870	COG1278	Cold shock
Tph_c24960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tph_c24980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tph_c24990	COG0601	transmembrane transport
Tph_c25070	COG2814	Major facilitator Superfamily
Tph_c25090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tph_c25140	COG4608	Belongs to the ABC transporter superfamily
Tph_c25150	COG0444	Belongs to the ABC transporter superfamily
Tph_c25190	COG0747	negative chemotaxis
Tph_c25200	COG4608	Belongs to the ABC transporter superfamily
Tph_c25220	COG1131	(ABC) transporter
Tph_c25240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tph_c25290	COG4608	Belongs to the ABC transporter superfamily
Tph_c25310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tph_c25330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tph_c25340	COG0601	transmembrane transport
Tph_c25370	COG1199	ATP-dependent helicase activity
Tph_c25410	COG2815	serine threonine protein kinase
Tph_c25410	COG0515	serine threonine protein kinase
Tph_c25420	COG0165	Argininosuccinate lyase
Tph_c25430	COG0137	argininosuccinate synthase activity
Tph_c25440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tph_c25450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tph_c25460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tph_c25470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tph_c25480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tph_c25500	COG2078	PFAM AMMECR1 domain protein
Tph_c25500	COG3885	ferrous iron binding
Tph_c25520	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tph_c25540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tph_c25560	COG0203	ribosomal protein L17
Tph_c25570	COG0202	RNA polymerase activity
Tph_c25580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tph_c25590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tph_c25600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tph_c25610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tph_c25620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tph_c25650	COG0563	adenylate kinase activity
Tph_c25660	COG0201	protein transport
Tph_c25670	COG0200	Binds to the 23S rRNA
Tph_c25680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tph_c25690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tph_c25700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tph_c25710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tph_c25720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tph_c25730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tph_c25740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tph_c25750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tph_c25760	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tph_c25770	COG0255	Belongs to the universal ribosomal protein uL29 family
Tph_c25780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tph_c25790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tph_c25810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tph_c25820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tph_c25830	COG0089	rRNA binding
Tph_c25840	COG0088	Forms part of the polypeptide exit tunnel
Tph_c25850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tph_c25860	COG0051	transcription antitermination factor activity, RNA binding
Tph_c25870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tph_c25880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tph_c25890	COG0049	tRNA binding
Tph_c25900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tph_c25910	COG1358	cellular component organization or biogenesis
Tph_c25920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tph_c25930	COG0085	RNA polymerase activity
Tph_c26010	COG3464	Transposase
Tph_c26050	COG0222	ribosome binding
Tph_c26060	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tph_c26070	COG0081	regulation of translation
Tph_c26080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tph_c26090	COG0250	Participates in transcription elongation, termination and antitermination
Tph_c26110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tph_c26180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tph_c26200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tph_c26210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tph_c26210	COG5322	oxidoreductase activity
Tph_c26250	COG3383	formate dehydrogenase (NAD+) activity
Tph_c26260	COG3383	formate dehydrogenase (NAD+) activity
Tph_c26270	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tph_c26280	COG0651	ATP synthesis coupled electron transport
Tph_c26290	COG0650	Formate hydrogenlyase subunit 4
Tph_c26300	COG4237	Hydrogenase 4 membrane
Tph_c26310	COG0651	ATP synthesis coupled electron transport
Tph_c26330	COG3261	NADH dehydrogenase
Tph_c26330	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Tph_c26340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tph_c26350	COG3260	NADH ubiquinone oxidoreductase 20
Tph_c26370	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Tph_c26380	COG0588	phosphoglycerate mutase activity
Tph_c26390	COG1910	domain protein
Tph_c26400	COG0725	ABC transporter, periplasmic molybdate-binding protein
Tph_c26410	COG4149	molybdate abc transporter
Tph_c26420	COG3842	ATPase activity
Tph_c26430	COG1028	Short-chain dehydrogenase reductase Sdr
Tph_c26440	COG1640	4-alpha-glucanotransferase
Tph_c26450	COG0438	transferase activity, transferring glycosyl groups
Tph_c26480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tph_c26500	COG0133	tryptophan synthase activity
Tph_c26510	COG0135	phosphoribosylanthranilate isomerase activity
Tph_c26520	COG0134	indole-3-glycerol-phosphate synthase activity
Tph_c26530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tph_c26530	COG0512	Glutamine amidotransferase of anthranilate synthase
Tph_c26550	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tph_c26560	COG0586	Pfam SNARE associated Golgi protein
Tph_c26580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tph_c26620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tph_c26630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tph_c26650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tph_c26670	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tph_c26680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tph_c26700	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tph_c26720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tph_c26740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tph_c26750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Tph_c26760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tph_c26770	COG1418	mRNA catabolic process
Tph_c26780	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Tph_c26800	COG0105	UTP biosynthetic process
Tph_c26820	COG0037	tRNA processing
Tph_c26870	COG1388	LysM domain
Tph_c26870	COG3858	chitin binding
Tph_c26890	COG0375	protein maturation
Tph_c26920	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Tph_c26950	COG0248	Ppx GppA phosphatase
Tph_c27000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tph_c27010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tph_c27020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tph_c27030	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Tph_c27090	COG3328	transposase activity
Tph_c27120	COG4786	Flagellar basal body rod
Tph_c27140	COG1609	Transcriptional regulator
Tph_c27160	COG5577	PFAM Coat F domain
Tph_c27170	COG2385	sporulation resulting in formation of a cellular spore
Tph_c27210	COG1725	Transcriptional regulator
Tph_c27290	COG3383	formate dehydrogenase (NAD+) activity
Tph_c27310	COG0303	'Molybdopterin
Tph_c27330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Tph_c27370	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tph_c27380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tph_c27390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tph_c27400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tph_c27410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tph_c27420	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tph_c27430	COG0356	it plays a direct role in the translocation of protons across the membrane
Tph_c27460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Tph_c27490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tph_c27500	COG0698	ribose 5-phosphate isomerase
Tph_c27520	COG1971	Probably functions as a manganese efflux pump
Tph_c27530	COG0009	L-threonylcarbamoyladenylate synthase
Tph_c27550	COG2890	protein-(glutamine-N5) methyltransferase activity
Tph_c27560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tph_c27570	COG3872	metal-dependent enzyme
Tph_c27580	COG0254	rRNA binding
Tph_c27590	COG2985	domain, Protein
Tph_c27590	COG0569	domain protein
Tph_c27610	COG0281	malic enzyme
Tph_c27620	COG3875	lactate racemase activity
Tph_c27670	COG5012	cobalamin binding
Tph_c27700	COG5012	cobalamin binding
Tph_c27740	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tph_c27750	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tph_c27760	COG5012	cobalamin binding
Tph_c27790	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Tph_c27800	COG0739	heme binding
Tph_c27810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tph_c27820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tph_c27850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tph_c27870	COG0504	CTP synthase activity
Tph_c27880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tph_c27900	COG5002	protein histidine kinase activity
Tph_c27940	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Tph_c27960	COG0523	cobalamin synthesis protein
Tph_c27980	COG5012	cobalamin binding
Tph_c27990	COG2188	Transcriptional regulator
Tph_c28010	COG5012	cobalamin binding
Tph_c28040	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Tph_c28070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tph_c28100	COG0739	heme binding
Tph_c28200	COG2385	sporulation resulting in formation of a cellular spore
Tph_c28210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Tph_c28230	COG3956	TIGRFAM MazG family protein
Tph_c28240	COG2244	polysaccharide biosynthetic process
Tph_c28250	COG2002	toxin-antitoxin pair type II binding
Tph_c28260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tph_c28270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tph_c28300	COG0193	aminoacyl-tRNA hydrolase activity
Tph_c28310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tph_c28330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tph_c28340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tph_c28350	COG2088	sporulation resulting in formation of a cellular spore
Tph_c28370	COG1802	Transcriptional regulator
Tph_c28380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tph_c28430	COG1376	ErfK ybiS ycfS ynhG family protein
Tph_c28440	COG2340	Cysteine-rich secretory protein family
Tph_c28470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tph_c28530	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tph_c28600	COG2340	Cysteine-rich secretory protein family
Tph_c28620	COG4466	Protein conserved in bacteria
Tph_c28660	COG1533	DNA photolyase activity
Tph_c28680	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Tph_c28690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tph_c28700	COG3583	domain protein
Tph_c28700	COG3584	3D domain protein
Tph_c28710	COG3584	3D domain protein
Tph_c28710	COG1388	LysM domain
Tph_c28720	COG0084	hydrolase, TatD family'
Tph_c28740	COG3464	Transposase
Tph_c28750	COG2002	toxin-antitoxin pair type II binding
Tph_c28760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tph_c28770	COG1774	PSP1 C-terminal conserved region
Tph_c28780	COG0470	DNA polymerase III
Tph_c28790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tph_c28800	COG1982	Orn Lys Arg decarboxylase major
Tph_c28850	COG0569	domain protein
Tph_c28910	COG0489	protein tyrosine kinase activity
Tph_c28930	COG0569	domain protein
Tph_c28960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tph_c28990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tph_c29000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tph_c29010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tph_c29040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tph_c29050	COG0668	transmembrane transport
Tph_c29070	COG0590	tRNA wobble adenosine to inosine editing
Tph_c29140	COG0390	transport system, permease component
Tph_c29150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity