locus-tag	class	description
Tmar_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tmar_0002	COG0592	DNA-directed DNA polymerase activity
Tmar_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tmar_0006	COG0187	DNA topoisomerase II activity
Tmar_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tmar_0008	COG0709	Synthesizes selenophosphate from selenide and ATP
Tmar_0009	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tmar_0021	COG5377	YqaJ viral recombinase family
Tmar_0022	COG3723	Recombinational DNA repair protein, rece pathway
Tmar_0023	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Tmar_0037	COG4695	Portal protein
Tmar_0057	COG4824	toxin secretion phage lysis holin
Tmar_0058	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tmar_0066	COG0697	spore germination
Tmar_0070	COG4708	membrane
Tmar_0072	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tmar_0073	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tmar_0074	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tmar_0077	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tmar_0078	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tmar_0079	COG3870	Protein conserved in bacteria
Tmar_0082	COG2002	toxin-antitoxin pair type II binding
Tmar_0084	COG0084	hydrolase, TatD family'
Tmar_0085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tmar_0086	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Tmar_0089	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tmar_0090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tmar_0091	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tmar_0092	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tmar_0093	COG2088	sporulation resulting in formation of a cellular spore
Tmar_0096	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tmar_0097	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tmar_0098	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tmar_0099	COG0193	aminoacyl-tRNA hydrolase activity
Tmar_0100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tmar_0101	COG2002	toxin-antitoxin pair type II binding
Tmar_0102	COG3956	TIGRFAM MazG family protein
Tmar_0109	COG1283	sodium-dependent phosphate transmembrane transporter activity
Tmar_0111	COG0492	ferredoxin-NADP+ reductase activity
Tmar_0113	COG0822	iron-sulfur transferase activity
Tmar_0114	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tmar_0115	COG0719	Fe-S assembly protein
Tmar_0116	COG0396	ATPase activity
Tmar_0117	COG1363	Peptidase, m42
Tmar_0118	COG2009	succinate dehydrogenase
Tmar_0121	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tmar_0122	COG2096	Adenosyltransferase
Tmar_0125	COG1260	myo-inositol-1-phosphate synthase
Tmar_0126	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tmar_0126	COG1213	nucleotidyl transferase
Tmar_0127	COG2135	peptidase activity
Tmar_0133	COG0037	tRNA processing
Tmar_0134	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tmar_0135	COG0617	tRNA 3'-terminal CCA addition
Tmar_0137	COG2986	histidine ammonia-lyase
Tmar_0138	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tmar_0140	COG3191	aminopeptidase activity
Tmar_0141	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tmar_0144	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tmar_0145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tmar_0146	COG0572	uridine kinase
Tmar_0151	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tmar_0153	COG0254	rRNA binding
Tmar_0154	COG3872	metal-dependent enzyme
Tmar_0155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tmar_0156	COG2890	protein-(glutamine-N5) methyltransferase activity
Tmar_0157	COG0009	L-threonylcarbamoyladenylate synthase
Tmar_0158	COG0698	ribose 5-phosphate isomerase
Tmar_0159	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tmar_0160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Tmar_0163	COG0356	it plays a direct role in the translocation of protons across the membrane
Tmar_0164	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tmar_0167	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tmar_0168	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tmar_0169	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tmar_0170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tmar_0171	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tmar_0172	COG2385	sporulation resulting in formation of a cellular spore
Tmar_0174	COG1609	Transcriptional regulator
Tmar_0176	COG4786	Flagellar basal body rod
Tmar_0179	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tmar_0180	COG1185	polyribonucleotide nucleotidyltransferase activity
Tmar_0182	COG0561	phosphatase activity
Tmar_0185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tmar_0188	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tmar_0190	COG3706	GGDEF domain
Tmar_0191	COG1040	competence protein
Tmar_0194	COG1256	bacterial-type flagellum assembly
Tmar_0194	COG4786	Flagellar basal body rod
Tmar_0195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tmar_0196	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tmar_0201	COG0653	protein targeting
Tmar_0203	COG2884	Cell division ATP-binding protein ftsE
Tmar_0204	COG2177	Part of the ABC transporter FtsEX involved in
Tmar_0205	COG0739	heme binding
Tmar_0206	COG0793	Belongs to the peptidase S41A family
Tmar_0208	COG0556	nucleotide-excision repair
Tmar_0209	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tmar_0210	COG0628	permease
Tmar_0212	COG0322	excinuclease ABC activity
Tmar_0215	COG1950	PFAM Membrane protein of
Tmar_0216	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tmar_0217	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tmar_0218	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tmar_0219	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tmar_0220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tmar_0221	COG0287	Prephenate dehydrogenase
Tmar_0222	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tmar_0225	COG2239	Acts as a magnesium transporter
Tmar_0227	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tmar_0231	COG1660	Displays ATPase and GTPase activities
Tmar_0232	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Tmar_0233	COG1481	regulation of sporulation
Tmar_0235	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Tmar_0236	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Tmar_0238	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tmar_0239	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tmar_0241	COG2188	Transcriptional regulator
Tmar_0242	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tmar_0244	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Tmar_0245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tmar_0246	COG2309	aminopeptidase activity
Tmar_0250	COG0640	Transcriptional regulator
Tmar_0251	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tmar_0252	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tmar_0252	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tmar_0253	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tmar_0253	COG0425	Belongs to the sulfur carrier protein TusA family
Tmar_0254	COG2210	Belongs to the sulfur carrier protein TusA family
Tmar_0255	COG0730	response to heat
Tmar_0257	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Tmar_0258	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tmar_0259	COG0736	holo-[acyl-carrier-protein] synthase activity
Tmar_0260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tmar_0260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tmar_0261	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tmar_0263	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tmar_0265	COG1573	uracil-dna glycosylase
Tmar_0266	COG0802	atpase or kinase
Tmar_0267	COG1214	PFAM Peptidase M22, glycoprotease
Tmar_0268	COG0456	acetyltransferase
Tmar_0269	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tmar_0270	COG0110	maltose O-acetyltransferase activity
Tmar_0271	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tmar_0272	COG0517	IMP dehydrogenase activity
Tmar_0272	COG0516	GMP reductase activity
Tmar_0273	COG0285	dihydrofolate synthase activity
Tmar_0274	COG0183	Belongs to the thiolase family
Tmar_0275	COG0303	'Molybdopterin
Tmar_0276	COG0315	cyclic pyranopterin monophosphate synthase activity
Tmar_0277	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tmar_0277	COG0315	cyclic pyranopterin monophosphate synthase activity
Tmar_0278	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tmar_0279	COG0459	protein refolding
Tmar_0282	COG0519	Catalyzes the synthesis of GMP from XMP
Tmar_0282	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tmar_0284	COG5002	protein histidine kinase activity
Tmar_0286	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tmar_0287	COG4166	transmembrane transport
Tmar_0288	COG0601	transmembrane transport
Tmar_0289	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tmar_0290	COG0444	Belongs to the ABC transporter superfamily
Tmar_0291	COG4608	Belongs to the ABC transporter superfamily
Tmar_0293	COG0601	transmembrane transport
Tmar_0294	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tmar_0296	COG4608	Belongs to the ABC transporter superfamily
Tmar_0298	COG0006	proline dipeptidase activity
Tmar_0299	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tmar_0300	COG0154	amidase activity
Tmar_0301	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tmar_0303	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
Tmar_0308	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tmar_0309	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tmar_0310	COG0649	NAD binding
Tmar_0311	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tmar_0312	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tmar_0315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tmar_0317	COG1007	ATP synthesis coupled electron transport
Tmar_0319	COG0475	glutathione-regulated potassium exporter activity
Tmar_0321	COG2010	Cytochrome c
Tmar_0326	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tmar_0328	COG0697	spore germination
Tmar_0332	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Tmar_0335	COG0714	Associated with various cellular activities
Tmar_0336	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tmar_0337	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tmar_0346	COG4086	secreted protein
Tmar_0347	COG0586	Pfam SNARE associated Golgi protein
Tmar_0349	COG2385	sporulation resulting in formation of a cellular spore
Tmar_0354	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tmar_0358	COG4974	Belongs to the 'phage' integrase family
Tmar_0366	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tmar_0369	COG0730	response to heat
Tmar_0371	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tmar_0373	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tmar_0374	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tmar_0375	COG2718	Belongs to the UPF0229 family
Tmar_0376	COG2719	SpoVR family
Tmar_0377	COG2766	serine protein kinase
Tmar_0380	COG0205	6-phosphofructokinase activity
Tmar_0382	COG2151	metal-sulfur cluster biosynthetic enzyme
Tmar_0382	COG0489	protein tyrosine kinase activity
Tmar_0383	COG1073	alpha beta
Tmar_0384	COG0527	aspartate kinase activity
Tmar_0386	COG2514	catechol 2,3-dioxygenase activity
Tmar_0391	COG0183	Belongs to the thiolase family
Tmar_0392	COG3547	Transposase (IS116 IS110 IS902 family)
Tmar_0394	COG0318	PFAM AMP-dependent synthetase and ligase
Tmar_0397	COG1063	alcohol dehydrogenase
Tmar_0398	COG1063	alcohol dehydrogenase
Tmar_0399	COG0662	Cupin 2, conserved barrel domain protein
Tmar_0402	COG1612	heme a metabolic process
Tmar_0403	COG0109	protoheme IX farnesyltransferase activity
Tmar_0404	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Tmar_0405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tmar_0406	COG1845	cytochrome c oxidase, subunit III
Tmar_0407	COG1845	cytochrome c oxidase, subunit III
Tmar_0410	COG2340	Cysteine-rich secretory protein family
Tmar_0420	COG1509	lysine 2,3-aminomutase activity
Tmar_0423	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tmar_0425	COG3773	Cell wall hydrolase
Tmar_0425	COG3409	Peptidoglycan-binding domain 1 protein
Tmar_0426	COG3409	Peptidoglycan-binding domain 1 protein
Tmar_0426	COG3773	Cell wall hydrolase
Tmar_0428	COG0237	dephospho-CoA kinase activity
Tmar_0431	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tmar_0432	COG1028	Short-chain dehydrogenase reductase Sdr
Tmar_0434	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tmar_0437	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tmar_0438	COG3279	Response regulator of the LytR AlgR family
Tmar_0439	COG3275	phosphorelay sensor kinase activity
Tmar_0440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tmar_0442	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmar_0443	COG0202	RNA polymerase activity
Tmar_0444	COG2222	sugar isomerase
Tmar_0451	COG0346	lactoylglutathione lyase activity
Tmar_0453	COG0789	Transcriptional regulator
Tmar_0454	COG0174	glutamine synthetase
Tmar_0458	COG1132	(ABC) transporter
Tmar_0459	COG3832	glyoxalase III activity
Tmar_0462	COG0038	chloride channel
Tmar_0464	COG1494	fructose-1,6-bisphosphatase
Tmar_0466	COG0693	protein deglycase activity
Tmar_0467	COG0725	ABC transporter, periplasmic molybdate-binding protein
Tmar_0468	COG4149	molybdate abc transporter
Tmar_0470	COG0726	polysaccharide deacetylase
Tmar_0471	COG4555	ABC transporter
Tmar_0475	COG1309	transcriptional regulator
Tmar_0477	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Tmar_0478	COG2181	nitrate reductase activity
Tmar_0478	COG0247	lactate metabolic process
Tmar_0479	COG0318	PFAM AMP-dependent synthetase and ligase
Tmar_0480	COG1607	acyl-coa hydrolase
Tmar_0482	COG4948	Mandelate Racemase Muconate Lactonizing
Tmar_0485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tmar_0487	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tmar_0489	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tmar_0491	COG0154	amidase activity
Tmar_0493	COG0463	Glycosyl transferase, family 2
Tmar_0497	COG1178	ABC-type Fe3 transport system permease component
Tmar_0498	COG3842	ATPase activity
Tmar_0499	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tmar_0500	COG1196	nuclear chromosome segregation
Tmar_0502	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tmar_0505	COG0477	Major facilitator Superfamily
Tmar_0511	COG4133	protoheme IX ABC transporter activity
Tmar_0513	COG1131	(ABC) transporter
Tmar_0516	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tmar_0517	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tmar_0523	COG0410	ABC transporter
Tmar_0524	COG1024	Enoyl-CoA hydratase
Tmar_0525	COG2348	transferase activity, transferring amino-acyl groups
Tmar_0526	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tmar_0527	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Tmar_0528	COG0011	TIGRFAM Protein of
Tmar_0529	COG0477	Major facilitator Superfamily
Tmar_0531	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Tmar_0532	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Tmar_0533	COG1268	BioY protein
Tmar_0534	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tmar_0535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tmar_0536	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tmar_0538	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tmar_0539	COG0137	argininosuccinate synthase activity
Tmar_0541	COG0165	Argininosuccinate lyase
Tmar_0543	COG1573	uracil-dna glycosylase
Tmar_0548	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Tmar_0550	COG4176	ABC-type proline glycine betaine transport system permease component
Tmar_0555	COG0735	belongs to the Fur family
Tmar_0556	COG1121	(ABC) transporter
Tmar_0557	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tmar_0558	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tmar_0559	COG2223	nitrite transmembrane transporter activity
Tmar_0567	COG0823	Involved in the tonB-independent uptake of proteins
Tmar_0567	COG1506	peptidase
Tmar_0567	COG4946	Tricorn protease homolog
Tmar_0568	COG0741	lytic transglycosylase activity
Tmar_0568	COG1196	nuclear chromosome segregation
Tmar_0568	COG0739	heme binding
Tmar_0570	COG2011	ABC-type metal ion transport system permease component
Tmar_0571	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Tmar_0572	COG0367	asparagine synthase
Tmar_0573	COG0683	leucine binding
Tmar_0574	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tmar_0579	COG0697	spore germination
Tmar_0581	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tmar_0584	COG4821	SIS domain
Tmar_0586	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tmar_0587	COG0363	glucosamine-6-phosphate deaminase activity
Tmar_0588	COG0561	phosphatase activity
Tmar_0589	COG0506	proline dehydrogenase activity
Tmar_0590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tmar_0590	COG0140	phosphoribosyl-ATP diphosphatase activity
Tmar_0591	COG0107	imidazoleglycerol-phosphate synthase activity
Tmar_0592	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tmar_0593	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tmar_0594	COG0131	Imidazoleglycerol-phosphate dehydratase
Tmar_0595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tmar_0596	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tmar_0597	COG0124	histidyl-tRNA synthetase
Tmar_0598	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tmar_0602	COG4496	protein, YerC YecD
Tmar_0610	COG0745	RESPONSE REGULATOR receiver
Tmar_0612	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Tmar_0616	COG1063	alcohol dehydrogenase
Tmar_0617	COG0235	Class ii aldolase
Tmar_0619	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tmar_0619	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tmar_0620	COG0668	transmembrane transport
Tmar_0622	COG0303	'Molybdopterin
Tmar_0624	COG0174	glutamine synthetase
Tmar_0626	COG0004	ammonium transporteR
Tmar_0627	COG0367	asparagine synthase
Tmar_0629	COG1733	regulation of RNA biosynthetic process
Tmar_0630	COG2272	Belongs to the type-B carboxylesterase lipase family
Tmar_0631	COG0067	glutamate synthase
Tmar_0631	COG0069	glutamate synthase activity
Tmar_0631	COG0070	glutamate synthase
Tmar_0636	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Tmar_0637	COG0438	transferase activity, transferring glycosyl groups
Tmar_0638	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Tmar_0641	COG2247	cell wall binding repeat
Tmar_0641	COG2385	sporulation resulting in formation of a cellular spore
Tmar_0643	COG0297	glycogen (starch) synthase activity
Tmar_0651	COG0411	ABC transporter
Tmar_0656	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
Tmar_0657	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tmar_0659	COG2318	DinB family
Tmar_0663	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tmar_0665	COG1459	type II secretion system
Tmar_0674	COG0662	Cupin 2, conserved barrel domain protein
Tmar_0674	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Tmar_0675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tmar_0680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tmar_0686	COG0601	transmembrane transport
Tmar_0687	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tmar_0688	COG0444	Belongs to the ABC transporter superfamily
Tmar_0690	COG0728	peptidoglycan biosynthetic process
Tmar_0691	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Tmar_0693	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tmar_0695	COG2208	phosphoserine phosphatase activity
Tmar_0697	COG1366	Belongs to the anti-sigma-factor antagonist family
Tmar_0699	COG0728	peptidoglycan biosynthetic process
Tmar_0701	COG0438	transferase activity, transferring glycosyl groups
Tmar_0702	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Tmar_0703	COG0390	transport system, permease component
Tmar_0704	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tmar_0707	COG1940	carbohydrate kinase activity
Tmar_0708	COG1840	ABC-type Fe3 transport system, periplasmic component
Tmar_0709	COG3842	ATPase activity
Tmar_0712	COG0165	Argininosuccinate lyase
Tmar_0717	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Tmar_0718	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tmar_0721	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tmar_0722	COG1131	(ABC) transporter
Tmar_0723	COG1131	(ABC) transporter
Tmar_0724	COG0842	Transport permease protein
Tmar_0726	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Tmar_0727	COG1349	DNA-binding transcription factor activity
Tmar_0729	COG2059	Chromate
Tmar_0731	COG4294	response to UV
Tmar_0732	COG1960	acyl-CoA dehydrogenase activity
Tmar_0736	COG1271	oxidase subunit
Tmar_0738	COG1316	TRANSCRIPTIONal
Tmar_0739	COG3706	GGDEF domain
Tmar_0741	COG1028	Short-chain dehydrogenase reductase Sdr
Tmar_0743	COG1115	amino acid carrier protein
Tmar_0746	COG0747	negative chemotaxis
Tmar_0747	COG0601	transmembrane transport
Tmar_0749	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Tmar_0751	COG1473	amidohydrolase
Tmar_0753	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tmar_0756	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tmar_0757	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tmar_0759	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tmar_0761	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tmar_0763	COG4176	ABC-type proline glycine betaine transport system permease component
Tmar_0764	COG2113	Glycine betaine
Tmar_0767	COG2133	pyrroloquinoline quinone binding
Tmar_0771	COG0745	RESPONSE REGULATOR receiver
Tmar_0772	COG5002	protein histidine kinase activity
Tmar_0772	COG3850	Histidine kinase
Tmar_0773	COG0492	ferredoxin-NADP+ reductase activity
Tmar_0774	COG0069	glutamate synthase activity
Tmar_0779	COG0483	inositol monophosphate 1-phosphatase activity
Tmar_0781	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tmar_0784	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Tmar_0785	COG1074	ATP-dependent DNA helicase activity
Tmar_0788	COG1028	Short-chain dehydrogenase reductase Sdr
Tmar_0789	COG0492	ferredoxin-NADP+ reductase activity
Tmar_0792	COG2252	PERMEase
Tmar_0797	COG2197	response regulator
Tmar_0800	COG0587	DNA-directed DNA polymerase activity
Tmar_0802	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Tmar_0807	COG1254	Belongs to the acylphosphatase family
Tmar_0809	COG0730	response to heat
Tmar_0811	COG2707	UPF0756 membrane protein
Tmar_0813	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Tmar_0816	COG5609	conserved protein (DUF2294)
Tmar_0817	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tmar_0818	COG3002	Belongs to the UPF0753 family
Tmar_0819	COG1164	Oligoendopeptidase f
Tmar_0820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tmar_0824	COG0531	amino acid
Tmar_0825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tmar_0826	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tmar_0827	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tmar_0829	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tmar_0830	COG0569	domain protein
Tmar_0831	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tmar_0836	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tmar_0837	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tmar_0837	COG0072	phenylalanine-tRNA ligase activity
Tmar_0838	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Tmar_0839	COG1796	DNA polymerase
Tmar_0839	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Tmar_0840	COG1193	negative regulation of DNA recombination
Tmar_0842	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tmar_0844	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tmar_0845	COG0217	transcriptional regulatory protein
Tmar_0847	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tmar_0848	COG0632	four-way junction helicase activity
Tmar_0849	COG2255	four-way junction helicase activity
Tmar_0851	COG1191	sigma factor activity
Tmar_0853	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tmar_0854	COG0343	queuine tRNA-ribosyltransferase activity
Tmar_0857	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tmar_0859	COG4770	biotin carboxylase activity
Tmar_0860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Tmar_0861	COG2001	Belongs to the MraZ family
Tmar_0862	COG0275	rRNA processing
Tmar_0864	COG0768	penicillin binding
Tmar_0865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tmar_0866	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tmar_0867	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tmar_0868	COG0772	Belongs to the SEDS family
Tmar_0869	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tmar_0870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tmar_0872	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tmar_0874	COG1191	sigma factor activity
Tmar_0875	COG1191	sigma factor activity
Tmar_0877	COG1873	PFAM PRC-barrel domain
Tmar_0879	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Tmar_0880	COG1799	cell septum assembly
Tmar_0881	COG0762	integral membrane protein
Tmar_0882	COG3599	regulation of cell shape
Tmar_0884	COG2801	Transposase and inactivated derivatives
Tmar_0885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tmar_0887	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Tmar_0889	COG1980	fructose-bisphosphate aldolase activity
Tmar_0891	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tmar_0892	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tmar_0893	COG0564	pseudouridine synthase activity
Tmar_0894	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tmar_0895	COG1929	Belongs to the glycerate kinase type-1 family
Tmar_0897	COG1024	Enoyl-CoA hydratase
Tmar_0897	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tmar_0898	COG0183	Belongs to the thiolase family
Tmar_0899	COG1960	acyl-CoA dehydrogenase activity
Tmar_0908	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tmar_0909	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tmar_0910	COG0436	Aminotransferase
Tmar_0912	COG1561	YicC-like family, N-terminal region
Tmar_0913	COG2052	Domain of unknown function (DUF370)
Tmar_0914	COG0194	GDP metabolic process
Tmar_0915	COG1758	RNA polymerase activity
Tmar_0916	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tmar_0917	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tmar_0918	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tmar_0919	COG2738	Putative neutral zinc metallopeptidase
Tmar_0921	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tmar_0922	COG0631	protein serine/threonine phosphatase activity
Tmar_0923	COG2815	serine threonine protein kinase
Tmar_0923	COG0515	serine threonine protein kinase
Tmar_0924	COG1162	GTPase activity
Tmar_0925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tmar_0926	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tmar_0927	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tmar_0929	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tmar_0931	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Tmar_0932	COG2814	Major facilitator Superfamily
Tmar_0933	COG0742	ribosomal rna small subunit methyltransferase
Tmar_0934	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tmar_0936	COG3314	Sporulation integral membrane protein YlbJ
Tmar_0940	COG1203	CRISPR-associated helicase, Cas3
Tmar_0944	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tmar_0945	COG2030	dehydratase
Tmar_0946	COG0416	fatty acid biosynthetic process
Tmar_0947	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tmar_0948	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tmar_0949	COG1028	Short-chain dehydrogenase reductase Sdr
Tmar_0950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tmar_0951	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tmar_0952	COG0571	ribonuclease III activity
Tmar_0953	COG2359	stage V sporulation protein S
Tmar_0954	COG1196	nuclear chromosome segregation
Tmar_0955	COG0552	protein localization to endoplasmic reticulum
Tmar_0956	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Tmar_0957	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tmar_0958	COG0228	four-way junction DNA binding
Tmar_0959	COG1837	Belongs to the UPF0109 family
Tmar_0960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tmar_0961	COG0336	Belongs to the RNA methyltransferase TrmD family
Tmar_0962	COG0335	large ribosomal subunit rRNA binding
Tmar_0963	COG0681	Belongs to the peptidase S26 family
Tmar_0964	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Tmar_0965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tmar_0966	COG0792	nuclease activity
Tmar_0968	COG4166	transmembrane transport
Tmar_0969	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tmar_0969	COG0758	DNA mediated transformation
Tmar_0970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tmar_0971	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Tmar_0973	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tmar_0974	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tmar_0975	COG1815	bacterial-type flagellum-dependent cell motility
Tmar_0979	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmar_0981	COG1157	protein secretion by the type III secretion system
Tmar_0985	COG1749	Flagellar hook protein flgE
Tmar_0986	COG1582	Flagellar protein (FlbD)
Tmar_0988	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmar_0989	COG1776	CheC inhibitor of MCP methylation
Tmar_0989	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmar_0990	COG2201	protein-glutamate methylesterase activity
Tmar_0992	COG1338	Plays a role in the flagellum-specific transport system
Tmar_0993	COG1987	bacterial-type flagellum assembly
Tmar_0994	COG1684	flagellar biosynthetic protein fliR
Tmar_0995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tmar_0996	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tmar_0998	COG0455	bacterial-type flagellum organization
Tmar_1000	COG1191	sigma factor activity
Tmar_1003	COG0052	Belongs to the universal ribosomal protein uS2 family
Tmar_1004	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tmar_1005	COG0528	UMP kinase activity
Tmar_1006	COG0233	cytoplasmic translational termination
Tmar_1009	COG0575	Belongs to the CDS family
Tmar_1011	COG0750	zinc metalloprotease
Tmar_1012	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tmar_1013	COG0442	prolyl-tRNA aminoacylation
Tmar_1015	COG0779	Required for maturation of 30S ribosomal subunits
Tmar_1016	COG0195	Participates in both transcription termination and antitermination
Tmar_1017	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Tmar_1019	COG3170	Tfp pilus assembly protein FimV
Tmar_1019	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tmar_1021	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tmar_1022	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Tmar_1023	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tmar_1024	COG0196	riboflavin kinase activity
Tmar_1026	COG1185	polyribonucleotide nucleotidyltransferase activity
Tmar_1027	COG0612	Peptidase, M16
Tmar_1028	COG0756	dUTP diphosphatase activity
Tmar_1031	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tmar_1033	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tmar_1034	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Tmar_1035	COG0527	aspartate kinase activity
Tmar_1036	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tmar_1037	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tmar_1038	COG0740	serine-type endopeptidase activity
Tmar_1040	COG1968	undecaprenyl-diphosphatase activity
Tmar_1041	COG1674	ftsk spoiiie
Tmar_1042	COG3858	chitin binding
Tmar_1045	COG1809	phosphosulfolactate synthase activity
Tmar_1048	COG1960	acyl-CoA dehydrogenase activity
Tmar_1049	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmar_1050	COG1686	Belongs to the peptidase S11 family
Tmar_1051	COG0017	Asparaginyl-tRNA synthetase
Tmar_1052	COG1426	Protein conserved in bacteria
Tmar_1053	COG1686	Belongs to the peptidase S11 family
Tmar_1054	COG0726	polysaccharide deacetylase
Tmar_1056	COG1205	dead DEAH box helicase
Tmar_1056	COG1111	helicase
Tmar_1057	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
Tmar_1058	COG1739	Uncharacterized protein family UPF0029
Tmar_1060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tmar_1061	COG1546	Belongs to the CinA family
Tmar_1061	COG1058	Belongs to the CinA family
Tmar_1064	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tmar_1065	COG2137	regulation of response to DNA damage stimulus
Tmar_1067	COG1692	metallophosphoesterase
Tmar_1069	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tmar_1070	COG0613	PHP domain protein
Tmar_1073	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmar_1074	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tmar_1075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tmar_1076	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tmar_1079	COG1160	GTP binding
Tmar_1080	COG0464	growth
Tmar_1081	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tmar_1083	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tmar_1090	COG0726	polysaccharide deacetylase
Tmar_1092	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tmar_1093	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tmar_1093	COG1199	ATP-dependent helicase activity
Tmar_1094	COG0406	alpha-ribazole phosphatase activity
Tmar_1095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tmar_1096	COG0402	S-adenosylhomocysteine deaminase activity
Tmar_1097	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tmar_1098	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tmar_1099	COG0105	UTP biosynthetic process
Tmar_1100	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Tmar_1103	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tmar_1106	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Tmar_1108	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tmar_1109	COG1160	GTP binding
Tmar_1111	COG0539	negative regulation of cytoplasmic translation
Tmar_1112	COG0204	Acyl-transferase
Tmar_1113	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tmar_1118	COG0644	oxidoreductase
Tmar_1119	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Tmar_1122	COG1187	pseudouridine synthase activity
Tmar_1124	COG0700	Nucleoside recognition
Tmar_1125	COG2715	membrane protein required for spore maturation
Tmar_1126	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tmar_1128	COG1793	dna ligase
Tmar_1129	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Tmar_1130	COG3874	Sporulation protein YtfJ
Tmar_1132	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tmar_1133	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tmar_1134	COG1994	Peptidase M50
Tmar_1135	COG0697	spore germination
Tmar_1137	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tmar_1140	COG1191	sigma factor activity
Tmar_1141	COG2172	sigma factor antagonist activity
Tmar_1142	COG1366	Belongs to the anti-sigma-factor antagonist family
Tmar_1143	COG1686	Belongs to the peptidase S11 family
Tmar_1144	COG1921	L-seryl-tRNASec selenium transferase activity
Tmar_1145	COG4974	Belongs to the 'phage' integrase family
Tmar_1148	COG0494	nUDIX hydrolase
Tmar_1157	COG0745	RESPONSE REGULATOR receiver
Tmar_1158	COG0750	zinc metalloprotease
Tmar_1159	COG0497	DNA recombination
Tmar_1160	COG1438	arginine binding
Tmar_1161	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tmar_1163	COG0473	3-isopropylmalate dehydrogenase activity
Tmar_1164	COG2195	Cleaves the N-terminal amino acid of tripeptides
Tmar_1165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tmar_1166	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tmar_1167	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tmar_1169	COG0142	geranyltranstransferase activity
Tmar_1170	COG1722	exodeoxyribonuclease VII activity
Tmar_1171	COG1570	exodeoxyribonuclease VII activity
Tmar_1172	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tmar_1173	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tmar_1176	COG1302	Protein conserved in bacteria
Tmar_1184	COG3854	ATPases associated with a variety of cellular activities
Tmar_1187	COG0006	proline dipeptidase activity
Tmar_1188	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tmar_1189	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tmar_1190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tmar_1191	COG0509	glycine decarboxylation via glycine cleavage system
Tmar_1192	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tmar_1195	COG0438	transferase activity, transferring glycosyl groups
Tmar_1209	COG2201	protein-glutamate methylesterase activity
Tmar_1216	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Tmar_1217	COG1191	sigma factor activity
Tmar_1218	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tmar_1219	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tmar_1222	COG4472	Bacterial protein of unknown function (DUF965)
Tmar_1223	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tmar_1225	COG0628	permease
Tmar_1228	COG0482	sulfurtransferase activity
Tmar_1229	COG1104	cysteine desulfurase activity
Tmar_1232	COG1959	2 iron, 2 sulfur cluster binding
Tmar_1234	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Tmar_1235	COG1435	thymidine kinase activity
Tmar_1239	COG3118	belongs to the thioredoxin family
Tmar_1240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tmar_1241	COG0124	histidyl-tRNA synthetase
Tmar_1242	COG1490	D-aminoacyl-tRNA deacylase activity
Tmar_1243	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tmar_1244	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Tmar_1244	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tmar_1246	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Tmar_1246	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Tmar_1247	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tmar_1248	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tmar_1252	COG1051	belongs to the nudix hydrolase family
Tmar_1255	COG1960	acyl-CoA dehydrogenase activity
Tmar_1258	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tmar_1258	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tmar_1259	COG0113	porphobilinogen synthase activity
Tmar_1260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tmar_1261	COG0181	hydroxymethylbilane synthase activity
Tmar_1263	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tmar_1264	COG2226	methyltransferase
Tmar_1265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tmar_1266	COG0045	succinate-CoA ligase (ADP-forming) activity
Tmar_1267	COG0281	malic enzyme
Tmar_1268	COG0039	L-malate dehydrogenase activity
Tmar_1270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tmar_1273	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Tmar_1275	COG2002	toxin-antitoxin pair type II binding
Tmar_1276	COG4472	Bacterial protein of unknown function (DUF965)
Tmar_1279	COG0301	tRNA thio-modification
Tmar_1283	COG1686	Belongs to the peptidase S11 family
Tmar_1285	COG0460	homoserine dehydrogenase
Tmar_1286	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tmar_1290	COG1489	DNA binding
Tmar_1292	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tmar_1293	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmar_1294	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tmar_1295	COG0697	spore germination
Tmar_1299	COG0372	Belongs to the citrate synthase family
Tmar_1300	COG1120	ATPase activity
Tmar_1301	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tmar_1302	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tmar_1303	COG1902	pentaerythritol trinitrate reductase activity
Tmar_1305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Tmar_1307	COG1131	(ABC) transporter
Tmar_1312	COG1309	transcriptional regulator
Tmar_1313	COG0649	NAD binding
Tmar_1315	COG1744	ABC transporter substrate-binding protein PnrA-like
Tmar_1319	COG1132	(ABC) transporter
Tmar_1320	COG1132	(ABC) transporter
Tmar_1323	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tmar_1324	COG1408	metallophosphoesterase
Tmar_1326	COG1122	ATPase activity
Tmar_1327	COG4721	ABC-type cobalt transport system, permease component
Tmar_1328	COG1028	Short-chain dehydrogenase reductase Sdr
Tmar_1332	COG1984	allophanate hydrolase subunit 2
Tmar_1333	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Tmar_1334	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Tmar_1336	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tmar_1337	COG0601	transmembrane transport
Tmar_1338	COG0747	negative chemotaxis
Tmar_1339	COG4608	Belongs to the ABC transporter superfamily
Tmar_1340	COG0444	Belongs to the ABC transporter superfamily
Tmar_1343	COG0318	PFAM AMP-dependent synthetase and ligase
Tmar_1346	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tmar_1349	COG0561	phosphatase activity
Tmar_1350	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Tmar_1351	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tmar_1352	COG0179	Fumarylacetoacetate (FAA) hydrolase
Tmar_1353	COG2391	methyltransferase activity
Tmar_1355	COG5002	protein histidine kinase activity
Tmar_1356	COG0745	RESPONSE REGULATOR receiver
Tmar_1357	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Tmar_1359	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tmar_1362	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tmar_1363	COG0438	transferase activity, transferring glycosyl groups
Tmar_1364	COG1098	S1 RNA binding domain
Tmar_1366	COG1803	Methylglyoxal synthase
Tmar_1368	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tmar_1368	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tmar_1369	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tmar_1372	COG2197	response regulator
Tmar_1373	COG4585	Histidine kinase
Tmar_1375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Tmar_1380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tmar_1381	COG0805	protein transport
Tmar_1382	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tmar_1384	COG0612	Peptidase, M16
Tmar_1385	COG0612	Peptidase, M16
Tmar_1389	COG0784	Response regulator, receiver
Tmar_1390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tmar_1391	COG0511	ligase activity, forming carbon-carbon bonds
Tmar_1392	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tmar_1394	COG0302	gtp cyclohydrolase
Tmar_1398	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Tmar_1400	COG0277	FAD linked oxidase domain protein
Tmar_1401	COG0247	lactate metabolic process
Tmar_1402	COG0277	FAD linked oxidase domain protein
Tmar_1403	COG0277	FAD linked oxidase domain protein
Tmar_1404	COG0584	glycerophosphoryl diester phosphodiesterase
Tmar_1405	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Tmar_1406	COG2080	2 iron, 2 sulfur cluster binding
Tmar_1406	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Tmar_1407	COG2080	2 iron, 2 sulfur cluster binding
Tmar_1408	COG1024	Enoyl-CoA hydratase
Tmar_1415	COG1309	transcriptional regulator
Tmar_1416	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tmar_1416	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tmar_1417	COG0151	Belongs to the GarS family
Tmar_1418	COG0138	bifunctional purine biosynthesis protein purh
Tmar_1420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tmar_1421	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Tmar_1422	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tmar_1423	COG0047	phosphoribosylformylglycinamidine synthase activity
Tmar_1424	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tmar_1425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tmar_1426	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tmar_1427	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tmar_1430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmar_1432	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tmar_1433	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tmar_1433	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tmar_1435	COG1126	abc transporter atp-binding protein
Tmar_1436	COG0765	amino acid transport
Tmar_1437	COG4597	amino acid ABC transporter
Tmar_1438	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tmar_1439	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tmar_1440	COG2154	pterin-4-alpha-carbinolamine dehydratase
Tmar_1442	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tmar_1443	COG1090	epimerase
Tmar_1450	COG0159	tryptophan synthase activity
Tmar_1451	COG0133	tryptophan synthase activity
Tmar_1452	COG0135	phosphoribosylanthranilate isomerase activity
Tmar_1453	COG0134	indole-3-glycerol-phosphate synthase activity
Tmar_1454	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tmar_1455	COG0512	Glutamine amidotransferase of anthranilate synthase
Tmar_1457	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tmar_1459	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tmar_1460	COG0746	molybdenum cofactor guanylyltransferase activity
Tmar_1462	COG1414	Transcriptional regulator
Tmar_1463	COG0747	negative chemotaxis
Tmar_1465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tmar_1466	COG2059	Chromate
Tmar_1467	COG0405	Gamma-glutamyltransferase
Tmar_1468	COG0444	Belongs to the ABC transporter superfamily
Tmar_1469	COG4608	Belongs to the ABC transporter superfamily
Tmar_1470	COG0549	Belongs to the carbamate kinase family
Tmar_1473	COG2233	PERMEase
Tmar_1474	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tmar_1475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tmar_1476	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Tmar_1477	COG0402	S-adenosylhomocysteine deaminase activity
Tmar_1481	COG2508	Transcriptional regulator
Tmar_1482	COG1024	Enoyl-CoA hydratase
Tmar_1483	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmar_1485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tmar_1485	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tmar_1486	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tmar_1496	COG0577	efflux transmembrane transporter activity
Tmar_1496	COG1136	(ABC) transporter
Tmar_1501	COG1216	Glycosyl transferase, family 2
Tmar_1503	COG0489	protein tyrosine kinase activity
Tmar_1504	COG2132	Multicopper oxidase
Tmar_1507	COG1276	copper resistance
Tmar_1509	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Tmar_1512	COG4377	Putative membrane peptidase family (DUF2324)
Tmar_1513	COG1012	belongs to the aldehyde dehydrogenase family
Tmar_1517	COG1309	transcriptional regulator
Tmar_1518	COG2068	MobA-Related Protein
Tmar_1525	COG2313	pseudouridylate synthase activity
Tmar_1526	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tmar_1526	COG3608	succinylglutamate desuccinylase aspartoacylase
Tmar_1527	COG0542	response to heat
Tmar_1528	COG1940	carbohydrate kinase activity
Tmar_1530	COG3547	Transposase (IS116 IS110 IS902 family)
Tmar_1531	COG1175	transmembrane transport
Tmar_1532	COG0395	ABC-type sugar transport system, permease component
Tmar_1534	COG1874	Beta-galactosidase
Tmar_1542	COG1668	transmembrane transport
Tmar_1543	COG4152	abc transporter atp-binding protein
Tmar_1544	COG1511	domain protein
Tmar_1549	COG0561	phosphatase activity
Tmar_1557	COG3964	amidohydrolase
Tmar_1561	COG2217	Heavy metal translocating P-type atpase
Tmar_1568	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tmar_1572	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tmar_1573	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tmar_1575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tmar_1576	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tmar_1577	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tmar_1578	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
Tmar_1579	COG2217	Heavy metal translocating P-type atpase
Tmar_1580	COG1937	Protein conserved in bacteria
Tmar_1581	COG2217	Heavy metal translocating P-type atpase
Tmar_1584	COG2217	Heavy metal translocating P-type atpase
Tmar_1586	COG2205	protein histidine kinase activity
Tmar_1587	COG0745	RESPONSE REGULATOR receiver
Tmar_1588	COG2132	Multicopper oxidase
Tmar_1590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tmar_1593	COG0109	protoheme IX farnesyltransferase activity
Tmar_1598	COG0501	Belongs to the peptidase M48B family
Tmar_1602	COG2217	Heavy metal translocating P-type atpase
Tmar_1610	COG5002	protein histidine kinase activity
Tmar_1612	COG0745	RESPONSE REGULATOR receiver
Tmar_1613	COG0318	PFAM AMP-dependent synthetase and ligase
Tmar_1615	COG0745	RESPONSE REGULATOR receiver
Tmar_1616	COG2205	protein histidine kinase activity
Tmar_1622	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Tmar_1623	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Tmar_1627	COG0626	cystathionine gamma-synthase activity
Tmar_1628	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Tmar_1629	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tmar_1629	COG1648	precorrin-2 dehydrogenase activity
Tmar_1630	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tmar_1633	COG0529	Catalyzes the synthesis of activated sulfate
Tmar_1633	COG2046	Belongs to the sulfate adenylyltransferase family
Tmar_1634	COG1335	isochorismatase
Tmar_1635	COG0745	RESPONSE REGULATOR receiver
Tmar_1636	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tmar_1637	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Tmar_1640	COG1461	Dihydroxyacetone kinase
Tmar_1641	COG2376	Dihydroxyacetone kinase
Tmar_1642	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Tmar_1644	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tmar_1645	COG0704	Plays a role in the regulation of phosphate uptake
Tmar_1646	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tmar_1647	COG0581	inorganic phosphate transmembrane transporter activity
Tmar_1648	COG0573	inorganic phosphate transmembrane transporter activity
Tmar_1650	COG5002	protein histidine kinase activity
Tmar_1652	COG1993	acr, cog1993
Tmar_1653	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tmar_1655	COG0114	fumarate hydratase activity
Tmar_1660	COG2323	membrane
Tmar_1661	COG2131	deaminase
Tmar_1663	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tmar_1664	COG0321	lipoyl(octanoyl) transferase activity
Tmar_1665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tmar_1667	COG3377	Domain of unknown function (DUF1805)
Tmar_1668	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Tmar_1672	COG0022	dehydrogenase e1 component
Tmar_1677	COG1846	Transcriptional regulator
Tmar_1680	COG0477	Major facilitator Superfamily
Tmar_1682	COG2050	protein possibly involved in aromatic compounds catabolism
Tmar_1686	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tmar_1689	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Tmar_1691	COG1363	Peptidase, m42
Tmar_1692	COG1363	Peptidase, m42
Tmar_1695	COG3711	transcriptional antiterminator
Tmar_1696	COG1263	PTS System
Tmar_1696	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tmar_1696	COG2190	(PTS) system
Tmar_1698	COG1263	PTS System
Tmar_1698	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tmar_1698	COG2190	(PTS) system
Tmar_1701	COG1827	regulation of RNA biosynthetic process
Tmar_1705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tmar_1706	COG0601	transmembrane transport
Tmar_1707	COG4166	transmembrane transport
Tmar_1709	COG0019	diaminopimelate decarboxylase activity
Tmar_1718	COG1028	Short-chain dehydrogenase reductase Sdr
Tmar_1720	COG1139	Iron-sulfur cluster binding protein
Tmar_1722	COG1725	Transcriptional regulator
Tmar_1723	COG1131	(ABC) transporter
Tmar_1728	COG0730	response to heat
Tmar_1738	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tmar_1739	COG0083	homoserine kinase activity
Tmar_1741	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tmar_1744	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmar_1747	COG0277	FAD linked oxidase domain protein
Tmar_1750	COG3181	Tripartite tricarboxylate transporter family receptor
Tmar_1751	COG1024	Enoyl-CoA hydratase
Tmar_1752	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tmar_1753	COG1802	Transcriptional regulator
Tmar_1754	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tmar_1760	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tmar_1760	COG3608	succinylglutamate desuccinylase aspartoacylase
Tmar_1763	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tmar_1765	COG0277	FAD linked oxidase domain protein
Tmar_1765	COG0247	lactate metabolic process
Tmar_1766	COG0077	Prephenate dehydratase
Tmar_1769	COG2224	Isocitrate lyase
Tmar_1771	COG0440	acetolactate synthase activity
Tmar_1772	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tmar_1773	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmar_1774	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tmar_1775	COG0066	3-isopropylmalate dehydratase activity
Tmar_1776	COG0473	3-isopropylmalate dehydrogenase activity
Tmar_1777	COG0129	dihydroxy-acid dehydratase activity
Tmar_1778	COG0028	Belongs to the TPP enzyme family
Tmar_1779	COG1414	Transcriptional regulator
Tmar_1780	COG4569	acetaldehyde dehydrogenase (acetylating) activity
Tmar_1781	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tmar_1787	COG0410	ABC transporter
Tmar_1790	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tmar_1796	COG4608	Belongs to the ABC transporter superfamily
Tmar_1799	COG0601	transmembrane transport
Tmar_1800	COG0747	negative chemotaxis
Tmar_1801	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tmar_1803	COG1012	belongs to the aldehyde dehydrogenase family
Tmar_1807	COG0318	PFAM AMP-dependent synthetase and ligase
Tmar_1809	COG1234	tRNA 3'-trailer cleavage
Tmar_1812	COG2030	dehydratase
Tmar_1819	COG1012	belongs to the aldehyde dehydrogenase family
Tmar_1821	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tmar_1824	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tmar_1828	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Tmar_1831	COG0697	spore germination
Tmar_1833	COG2031	fatty acid transporter
Tmar_1837	COG0693	protein deglycase activity
Tmar_1840	COG1105	Belongs to the carbohydrate kinase PfkB family
Tmar_1843	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tmar_1844	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tmar_1845	COG4821	SIS domain
Tmar_1847	COG3037	sugar-specific permease SgaT UlaA
Tmar_1852	COG1960	acyl-CoA dehydrogenase activity
Tmar_1855	COG0352	thiamine-phosphate diphosphorylase activity
Tmar_1856	COG2022	thiamine diphosphate biosynthetic process
Tmar_1857	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tmar_1863	COG1063	alcohol dehydrogenase
Tmar_1869	COG0028	Belongs to the TPP enzyme family
Tmar_1871	COG2208	phosphoserine phosphatase activity
Tmar_1872	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tmar_1873	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tmar_1874	COG0643	Histidine kinase
Tmar_1874	COG2198	Histidine kinase
Tmar_1875	COG0835	chemotaxis
Tmar_1877	COG2201	protein-glutamate methylesterase activity
Tmar_1881	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tmar_1883	COG0438	transferase activity, transferring glycosyl groups
Tmar_1884	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tmar_1885	COG3842	ATPase activity
Tmar_1886	COG0395	ABC-type sugar transport system, permease component
Tmar_1887	COG1175	transmembrane transport
Tmar_1889	COG1653	transport
Tmar_1909	COG1113	amino acid transport
Tmar_1914	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Tmar_1916	COG1131	(ABC) transporter
Tmar_1919	COG0714	Associated with various cellular activities
Tmar_1926	COG1131	(ABC) transporter
Tmar_1928	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Tmar_1933	COG1162	GTPase activity
Tmar_1943	COG4608	Belongs to the ABC transporter superfamily
Tmar_1946	COG0601	transmembrane transport
Tmar_1947	COG0747	negative chemotaxis
Tmar_1948	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tmar_1956	COG1131	(ABC) transporter
Tmar_1957	COG2801	Transposase and inactivated derivatives
Tmar_1963	COG1331	Highly conserved protein containing a thioredoxin domain
Tmar_1967	COG3959	Transketolase, thiamine diphosphate binding domain
Tmar_1968	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tmar_1971	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tmar_1972	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tmar_1973	COG1121	(ABC) transporter
Tmar_1975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tmar_1978	COG0351	phosphomethylpyrimidine kinase
Tmar_1980	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Tmar_1981	COG0352	thiamine-phosphate diphosphorylase activity
Tmar_1982	COG2814	Major facilitator Superfamily
Tmar_1986	COG3842	ATPase activity
Tmar_1990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tmar_1991	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tmar_1991	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tmar_1992	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Tmar_1995	COG0577	efflux transmembrane transporter activity
Tmar_1996	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tmar_1997	COG1136	(ABC) transporter
Tmar_1997	COG0577	efflux transmembrane transporter activity
Tmar_1998	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Tmar_1999	COG2079	MmgE PrpD family protein
Tmar_2000	COG0372	Belongs to the citrate synthase family
Tmar_2005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tmar_2005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tmar_2008	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tmar_2010	COG0604	alcohol dehydrogenase
Tmar_2012	COG3842	ATPase activity
Tmar_2013	COG0494	nUDIX hydrolase
Tmar_2014	COG0861	Integral membrane protein TerC family
Tmar_2015	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Tmar_2015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tmar_2016	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tmar_2016	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Tmar_2017	COG0859	PFAM glycosyl transferase family 9
Tmar_2020	COG3395	kinase activity
Tmar_2021	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Tmar_2022	COG2610	gluconate transmembrane transporter activity
Tmar_2025	COG0564	pseudouridine synthase activity
Tmar_2026	COG0822	iron-sulfur transferase activity
Tmar_2027	COG2897	thiosulfate sulfurtransferase activity
Tmar_2030	COG3949	Membrane
Tmar_2031	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tmar_2032	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tmar_2033	COG1278	Cold shock
Tmar_2034	COG1252	NADH dehydrogenase
Tmar_2038	COG2814	Major facilitator Superfamily
Tmar_2040	COG0012	GTP binding
Tmar_2042	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Tmar_2044	COG0719	Fe-S assembly protein
Tmar_2045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tmar_2046	COG0284	orotidine-5'-phosphate decarboxylase activity
Tmar_2047	COG0167	dihydroorotate dehydrogenase activity
Tmar_2049	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tmar_2050	COG0505	Belongs to the CarA family
Tmar_2051	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tmar_2052	COG0540	Belongs to the ATCase OTCase family
Tmar_2053	COG2217	Heavy metal translocating P-type atpase
Tmar_2054	COG0640	Transcriptional regulator
Tmar_2057	COG1376	ErfK ybiS ycfS ynhG family protein
Tmar_2058	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tmar_2062	COG0785	Cytochrome C biogenesis protein
Tmar_2070	COG4412	M6 family metalloprotease domain protein
Tmar_2070	COG3291	Pkd domain containing protein
Tmar_2076	COG0037	tRNA processing
Tmar_2078	COG2045	Belongs to the ComB family
Tmar_2079	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tmar_2080	COG1138	Cytochrome C-type biogenesis protein
Tmar_2081	COG3088	subunit of a heme lyase
Tmar_2081	COG4235	cytochrome complex assembly
Tmar_2082	COG4347	Protein of unknown function (DUF1405)
Tmar_2083	COG3773	Cell wall hydrolase
Tmar_2083	COG3409	Peptidoglycan-binding domain 1 protein
Tmar_2084	COG1078	dGTPase activity
Tmar_2085	COG0314	molybdopterin synthase activity
Tmar_2088	COG3639	organic phosphonate transmembrane transporter activity
Tmar_2089	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Tmar_2091	COG0840	transmembrane signaling receptor activity
Tmar_2092	COG0277	FAD linked oxidase domain protein
Tmar_2095	COG2201	protein-glutamate methylesterase activity
Tmar_2098	COG2198	Histidine kinase
Tmar_2098	COG0643	Histidine kinase
Tmar_2099	COG2201	protein-glutamate methylesterase activity
Tmar_2100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tmar_2105	COG1363	Peptidase, m42
Tmar_2107	COG2226	methyltransferase
Tmar_2110	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tmar_2115	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tmar_2117	COG2197	response regulator
Tmar_2118	COG4585	Histidine kinase
Tmar_2120	COG0842	Transport permease protein
Tmar_2120	COG1511	domain protein
Tmar_2121	COG1131	(ABC) transporter
Tmar_2124	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tmar_2127	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tmar_2128	COG0358	DNA primase activity
Tmar_2129	COG0183	Belongs to the thiolase family
Tmar_2130	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tmar_2131	COG1024	Enoyl-CoA hydratase
Tmar_2133	COG2151	metal-sulfur cluster biosynthetic enzyme
Tmar_2136	COG3396	Phenylacetate-CoA oxygenase
Tmar_2137	COG1309	transcriptional regulator
Tmar_2140	COG5002	protein histidine kinase activity
Tmar_2148	COG3279	Response regulator of the LytR AlgR family
Tmar_2149	COG3275	phosphorelay sensor kinase activity
Tmar_2150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tmar_2151	COG0598	Magnesium transport protein CorA
Tmar_2155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tmar_2157	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tmar_2159	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tmar_2159	COG0574	Belongs to the PEP-utilizing enzyme family
Tmar_2160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tmar_2162	COG0751	glycine-tRNA ligase activity
Tmar_2163	COG0752	glycyl-tRNA synthetase alpha subunit
Tmar_2165	COG1381	Involved in DNA repair and RecF pathway recombination
Tmar_2166	COG2239	Acts as a magnesium transporter
Tmar_2167	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tmar_2168	COG1470	cell adhesion involved in biofilm formation
Tmar_2170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tmar_2171	COG1480	7TM receptor with intracellular HD hydrolase
Tmar_2172	COG1702	phosphate starvation-inducible protein PhoH
Tmar_2176	COG4864	UPF0365 protein
Tmar_2177	COG1030	water channel activity
Tmar_2179	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tmar_2180	COG0537	adenosine 5'-monophosphoramidase activity
Tmar_2181	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tmar_2182	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tmar_2183	COG2264	protein methyltransferase activity
Tmar_2185	COG0443	Heat shock 70 kDa protein
Tmar_2186	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tmar_2187	COG1420	regulation of RNA biosynthetic process
Tmar_2188	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tmar_2189	COG0481	GTPase activity
Tmar_2193	COG0268	Binds directly to 16S ribosomal RNA
Tmar_2194	COG1466	dna polymerase III delta subunit
Tmar_2196	COG1596	polysaccharide export
Tmar_2196	COG1555	photosystem II stabilization
Tmar_2197	COG0495	leucyl-tRNA aminoacylation
Tmar_2198	COG0799	negative regulation of ribosome biogenesis
Tmar_2200	COG1713	HD superfamily hydrolase involved in NAD metabolism
Tmar_2201	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tmar_2202	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tmar_2204	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tmar_2205	COG2868	ribosomal protein
Tmar_2206	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tmar_2207	COG1530	ribonuclease E activity
Tmar_2209	COG4942	peptidase
Tmar_2210	COG0772	Belongs to the SEDS family
Tmar_2211	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tmar_2212	COG2894	cell division
Tmar_2213	COG0850	regulation of cytokinetic process
Tmar_2216	COG1792	Involved in formation and maintenance of cell shape
Tmar_2217	COG1077	Cell shape determining protein MreB Mrl
Tmar_2218	COG2003	Belongs to the UPF0758 family
Tmar_2219	COG0424	maF-like protein
Tmar_2221	COG0525	valine-tRNA ligase activity
Tmar_2223	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tmar_2224	COG1067	ATP-dependent peptidase activity
Tmar_2224	COG0470	DNA polymerase III
Tmar_2225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tmar_2226	COG0740	serine-type endopeptidase activity
Tmar_2227	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tmar_2228	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tmar_2231	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tmar_2235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tmar_2236	COG0557	exoribonuclease II activity
Tmar_2237	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tmar_2238	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tmar_2239	COG0148	phosphopyruvate hydratase activity
Tmar_2240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Tmar_2241	COG0149	triose-phosphate isomerase activity
Tmar_2242	COG0126	phosphoglycerate kinase activity
Tmar_2244	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tmar_2245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tmar_2246	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tmar_2248	COG1012	belongs to the aldehyde dehydrogenase family
Tmar_2249	COG0735	belongs to the Fur family
Tmar_2255	COG0003	Pfam Anion-transporting ATPase
Tmar_2256	COG0003	Pfam Anion-transporting ATPase
Tmar_2258	COG1966	Carbon starvation protein
Tmar_2260	COG0439	Biotin carboxylase
Tmar_2261	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tmar_2262	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tmar_2263	COG0101	tRNA pseudouridine synthase activity
Tmar_2264	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tmar_2265	COG1122	ATPase activity
Tmar_2266	COG1122	ATPase activity
Tmar_2267	COG0203	ribosomal protein L17
Tmar_2268	COG0202	RNA polymerase activity
Tmar_2269	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tmar_2270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tmar_2271	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tmar_2272	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tmar_2275	COG0563	adenylate kinase activity
Tmar_2276	COG0201	protein transport
Tmar_2277	COG0200	Binds to the 23S rRNA
Tmar_2278	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tmar_2279	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tmar_2280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tmar_2281	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tmar_2282	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tmar_2283	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tmar_2284	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tmar_2285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tmar_2286	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tmar_2287	COG0255	Belongs to the universal ribosomal protein uL29 family
Tmar_2288	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tmar_2289	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tmar_2290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tmar_2291	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tmar_2292	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tmar_2293	COG0089	rRNA binding
Tmar_2294	COG0088	Forms part of the polypeptide exit tunnel
Tmar_2295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tmar_2296	COG0051	transcription antitermination factor activity, RNA binding
Tmar_2298	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tmar_2299	COG0049	tRNA binding
Tmar_2300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tmar_2301	COG1358	cellular component organization or biogenesis
Tmar_2302	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tmar_2303	COG0085	RNA polymerase activity
Tmar_2304	COG0222	ribosome binding
Tmar_2305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tmar_2306	COG0081	regulation of translation
Tmar_2307	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tmar_2308	COG0250	Participates in transcription elongation, termination and antitermination
Tmar_2309	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tmar_2310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tmar_2311	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tmar_2313	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tmar_2314	COG0215	cysteine-tRNA ligase activity
Tmar_2315	COG1045	serine acetyltransferase
Tmar_2316	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Tmar_2317	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tmar_2317	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tmar_2318	COG4956	integral membrane protein (PIN domain superfamily)
Tmar_2319	COG1329	Transcriptional regulator
Tmar_2321	COG2046	Belongs to the sulfate adenylyltransferase family
Tmar_2322	COG0175	sulfate reduction
Tmar_2323	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Tmar_2324	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Tmar_2325	COG0542	response to heat
Tmar_2326	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Tmar_2329	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Tmar_2330	COG1324	tolerance protein
Tmar_2331	COG1522	sequence-specific DNA binding
Tmar_2332	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Tmar_2333	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tmar_2337	COG0616	signal peptide processing
Tmar_2338	COG0504	CTP synthase activity
Tmar_2339	COG0018	arginyl-trna synthetase
Tmar_2340	COG0010	Belongs to the arginase family
Tmar_2341	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tmar_2344	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Tmar_2345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tmar_2349	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tmar_2350	COG0305	Participates in initiation and elongation during chromosome replication
Tmar_2351	COG0359	binds to the 23S rRNA
Tmar_2353	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tmar_2354	COG0629	single-stranded DNA binding
Tmar_2355	COG0360	Binds together with S18 to 16S ribosomal RNA
Tmar_2356	COG4481	Protein conserved in bacteria
Tmar_2358	COG0410	ABC transporter
Tmar_2359	COG0411	ABC transporter
Tmar_2361	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tmar_2364	COG1597	lipid kinase activity
Tmar_2366	COG1475	DNA binding
Tmar_2367	COG1192	Involved in chromosome partitioning
Tmar_2369	COG0357	Ribosomal RNA small subunit methyltransferase G
Tmar_2370	COG1847	R3H domain protein
Tmar_2371	COG0706	membrane insertase activity
Tmar_2372	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tmar_2373	COG0594	ribonuclease P activity
Tmar_2374	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Tmar_2375	COG2801	Transposase and inactivated derivatives
Tmar_R0053	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII