locus-tag class description E1B22_00025 ENOG41082BM Transcriptional regulator, arsr family E1B22_00050 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) E1B22_00055 ENOG4105P8F nudix hydrolase E1B22_00065 ENOG4105K6S Short-chain dehydrogenase reductase Sdr E1B22_00075 ENOG4107QR9 Iron-sulfur cluster binding protein E1B22_00095 ENOG4105CJ1 ABC, transporter E1B22_00135 ENOG4105D5G Transposase E1B22_00150 ENOG4105CBC glutamate synthase E1B22_00155 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) E1B22_00180 ENOG4105DM4 PTS System E1B22_00190 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) E1B22_00210 ENOG4105C0W non-ribosomal peptide synthetase E1B22_00220 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E1B22_00225 ENOG4105D5G Transposase E1B22_00230 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E1B22_00250 ENOG4107TYC hydantoinase B oxoprolinase E1B22_00255 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) E1B22_00260 ENOG4105HKX acetone carboxylase, gamma subunit E1B22_00265 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E1B22_00270 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family E1B22_00295 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) E1B22_00305 ENOG4105D5G Transposase E1B22_00335 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family E1B22_00340 ENOG4107T8T UPF0173 metal-dependent hydrolase E1B22_00345 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E1B22_00355 ENOG4105CQB FAD linked oxidase domain protein E1B22_00360 ENOG4108YYS metal-dependent hydrolase (By similarity) E1B22_00375 ENOG4105CQC Prephenate dehydratase E1B22_00380 ENOG4105D5G Transposase E1B22_00390 ENOG4105D5G Transposase E1B22_00420 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) E1B22_00425 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E1B22_00430 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E1B22_00435 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E1B22_00440 ENOG4105C01 Dihydroxy-acid dehydratase E1B22_00445 ENOG4105C7K acetolactate synthase E1B22_00455 ENOG4105CKI cobalamin synthesis protein E1B22_00470 ENOG4105HDK L-asparaginase E1B22_00505 ENOG4107RHR regulatoR E1B22_00510 ENOG4107QKR Dehydrogenase E1B22_00515 ENOG4105CPP Dehydrogenase, E1 component E1B22_00520 ENOG4107RUY (E1 component), alpha subunit E1B22_00530 ENOG410787A Pts system, glucitol sorbitol-specific E1B22_00535 ENOG4105DZY Pts system, glucitol sorbitol-specific E1B22_00540 ENOG4105VI0 Pts system, glucitol sorbitol-specific E1B22_00550 ENOG4105DT3 PTS system, galactitol-specific IIc component E1B22_00555 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E1B22_00580 ENOG410900P UPF0336 protein E1B22_00590 ENOG4105DFD Na H antiporter E1B22_00595 ENOG4107EPV Aminotransferase class V E1B22_00615 ENOG4106IPI cyclase, family E1B22_00630 ENOG4105C1G acyl-Coa dehydrogenase E1B22_00665 ENOG4105C26 Dehydrogenase E1B22_00685 ENOG4105E1K spore germination protein E1B22_00690 ENOG4108Q5U germination protein, ger(x)c family E1B22_00730 ENOG4108Z86 Glutamine amidotransferase E1B22_00745 ENOG4105E1K spore germination protein E1B22_00750 ENOG4105CRW Short chain fatty acid transporter E1B22_00755 ENOG4105X1P Steroid delta-isomerase E1B22_00770 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) E1B22_00775 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) E1B22_00780 ENOG41080HI glycine oxidase E1B22_00785 ENOG4107V8H Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) E1B22_00790 ENOG4108Z0Z intracellular protease Pfpi family E1B22_00795 ENOG4105CFM UPF0317 protein E1B22_00800 ENOG4105E7W lamb ycsf family protein E1B22_00810 ENOG4105P4J Allophanate hydrolase, subunit 1 E1B22_00830 ENOG4105D5G Transposase E1B22_00835 ENOG4105CEY Amp-dependent synthetase and ligase E1B22_00840 ENOG4105C1G acyl-Coa dehydrogenase E1B22_00845 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) E1B22_00865 ENOG4106IJN integrase catalytic domain-containing protein E1B22_00870 ENOG4105F5W AtP-binding protein E1B22_00885 ENOG4105D5G Transposase E1B22_00890 ENOG4105D5G Transposase E1B22_00910 ENOG4105C0F tryptophanase EC 4.1.99.1 E1B22_00920 ENOG4105D5G Transposase E1B22_00925 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) E1B22_00930 ENOG4107RB3 L-asparaginase E1B22_00940 ENOG4105CKI cobalamin synthesis protein E1B22_00975 ENOG4105CHR reductase E1B22_00990 ENOG4105CR4 methylisocitrate lyase E1B22_01015 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E1B22_01020 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E1B22_01030 ENOG4105DRR Transcriptional regulator, GntR family E1B22_01080 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E1B22_01085 ENOG4105CJ1 ABC, transporter E1B22_01095 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase E1B22_01115 ENOG4106KE4 Dehydrogenase E1B22_01135 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E1B22_01180 ENOG4105CIG ABC transporter E1B22_01190 ENOG4105DZR Type I site-specific deoxyribonuclease E1B22_01195 ENOG4107XZC Restriction modification system DNA (Specificity E1B22_01205 ENOG4105D5G Transposase E1B22_01215 ENOG4108I5C dEAD DEAH box helicase E1B22_01230 ENOG4105EA8 2-Nitropropane dioxygenase E1B22_01240 ENOG4105C7Z Conserved Protein E1B22_01245 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E1B22_01255 ENOG4105D5G Transposase E1B22_01270 ENOG4105CMG Carbohydrate kinase E1B22_01280 ENOG4105E2R ROK family E1B22_01295 ENOG4108HHA Transketolase E1B22_01300 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E1B22_01310 ENOG4105DSE periplasmic solute binding protein E1B22_01315 ENOG4105CC5 ABC transporter E1B22_01320 ENOG4105DIK (ABC) transporter E1B22_01330 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E1B22_01360 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase E1B22_01365 ENOG4105C0R drug resistance transporter emrb qaca subfamily E1B22_01375 ENOG4108IJ9 (ABC) transporter E1B22_01400 ENOG4105ETU transcriptional activator (TenA E1B22_01405 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) E1B22_01410 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) E1B22_01415 ENOG4105G63 Type III effector Hrp-dependent E1B22_01450 ENOG4105DXD 2-methylcitrate dehydratase E1B22_01475 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E1B22_01480 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E1B22_01485 ENOG4108QXE glycerophosphoryl diester phosphodiesterase E1B22_01495 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E1B22_01515 ENOG4105CG3 alpha amylase, catalytic region E1B22_01520 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component E1B22_01525 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component E1B22_01535 ENOG4108IJ9 (ABC) transporter E1B22_01540 ENOG4108ZCF integral membrane protein E1B22_01545 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) E1B22_01550 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) E1B22_01555 ENOG4105DKP glycosyl transferase, family 9 E1B22_01565 ENOG4105MVE transcriptional regulator E1B22_01570 ENOG4105G63 Type III effector Hrp-dependent E1B22_01575 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E1B22_01580 ENOG4105C6Z Gluconate E1B22_01600 ENOG4107YH3 SUF system FeS assembly protein, NifU family E1B22_01605 ENOG4105KHC sulfurtransferase E1B22_01615 ENOG4105C31 Tryptophanyl-tRNA synthetase E1B22_01620 ENOG4108K88 Membrane E1B22_01625 ENOG4107ZQN disulfide bond E1B22_01650 ENOG4105VEQ Cold shock protein E1B22_01685 ENOG4105C3G gtp-binding protein E1B22_01705 ENOG4105D5G Transposase E1B22_01720 ENOG4108JYZ YitT family E1B22_01730 ENOG4105DIW FeS assembly protein SUFB E1B22_01740 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) E1B22_01745 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) E1B22_01750 ENOG4105CS7 Catalyzes the conversion of dihydroorotate to orotate E1B22_01765 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E1B22_01815 ENOG4105D78 K07001 NTE family protein E1B22_01835 ENOG4107QIV Cytochrome c biogenesis protein E1B22_01875 ENOG4105C3F Signal peptidase i E1B22_01890 ENOG4107G87 m6 family metalloprotease domain protein E1B22_01910 ENOG4105CVJ phosphoglycerate mutase E1B22_01925 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) E1B22_01940 ENOG4108SQ9 flavin reductase domain protein, FMN-binding E1B22_01945 ENOG4108N5B 2-phosphosulfolactate phosphatase E1B22_01950 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) E1B22_01955 ENOG4105DA4 cytochrome c-type biogenesis protein E1B22_01960 ENOG4105KWW Biogenesis protein E1B22_01970 ENOG4105F0V Cell wall hydrolase E1B22_01975 ENOG4105DCI Phosphohydrolase E1B22_01980 ENOG4108ZAF Molybdopterin E1B22_01995 ENOG4105S7S phosphonate abc transporter E1B22_02010 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E1B22_02015 ENOG4105E0C molybdate abc transporter E1B22_02030 ENOG41085W3 Transposase E1B22_02035 ENOG4105D5G Transposase E1B22_02075 ENOG4105EQR Transposase IS116 IS110 IS902 E1B22_02130 ENOG4105D5G Transposase E1B22_02145 ENOG4105CQB FAD linked oxidase domain protein E1B22_02160 ENOG4107YTP response regulator receiver protein E1B22_02165 ENOG4107SDU Methyl-accepting chemotaxis E1B22_02170 ENOG4108V3W Chemotaxis protein, CheW E1B22_02175 ENOG4105CBS Chea signal transduction histidine kinase E1B22_02180 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) E1B22_02185 ENOG4105BZU Histidine kinase E1B22_02205 ENOG4105CN9 Peptidase m42 family protein E1B22_02220 ENOG41089UC methyltransferase, type 11 E1B22_02260 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E1B22_02285 ENOG4105WH1 Two component transcriptional regulator luxr family E1B22_02290 ENOG4105BZU Histidine kinase E1B22_02300 ENOG41090VJ ABC-2 type transporter E1B22_02305 ENOG4105CJ1 ABC, transporter E1B22_02320 ENOG4105CY0 Metallo-Beta-Lactamase E1B22_02335 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E1B22_02340 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E1B22_02345 ENOG4105CHU acetyl-coa acetyltransferase E1B22_02350 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E1B22_02355 ENOG4108UKI Enoyl-CoA hydratase E1B22_02360 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit E1B22_02375 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit E1B22_02405 ENOG4105DY9 regulatoR E1B22_02420 ENOG4105D7N magnesium and cobalt transport protein CorA E1B22_02445 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E1B22_02450 ENOG4105KPY Small multidrug resistance protein E1B22_02455 ENOG4107S91 Sodium hydrogen exchanger E1B22_02460 ENOG4105NCW Trka-c domain protein E1B22_02465 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) E1B22_02470 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) E1B22_02495 ENOG4105C38 Glycyl-tRNA synthetase beta subunit E1B22_02500 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit E1B22_02510 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) E1B22_02520 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) E1B22_02525 ENOG4108R5T secreted protein E1B22_02535 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) E1B22_02565 ENOG4105DI5 UPF0365 protein E1B22_02570 ENOG4105F7J membrane-bound serine protease E1B22_02580 ENOG4105VCC 30S ribosomal protein S21 E1B22_02585 ENOG4107YU2 histidine triad (hIT) protein E1B22_02590 ENOG4105CPF Cell wall formation (By similarity) E1B22_02600 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) E1B22_02610 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) E1B22_02615 ENOG4105CFG Acts as a chaperone (By similarity) E1B22_02620 ENOG4107Z9D Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ E1B22_02625 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) E1B22_02630 ENOG4105CSA Coproporphyrinogen iii oxidase E1B22_02635 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) E1B22_02655 ENOG41083CD Binds directly to 16S ribosomal RNA (By similarity) E1B22_02680 ENOG4105C8T Leucyl-tRNA synthetase E1B22_02695 ENOG4108KGH TRANSCRIPTIONal E1B22_02700 ENOG4108WF2 Metal Dependent Phosphohydrolase E1B22_02705 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) E1B22_02710 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control E1B22_02720 ENOG4105K46 50S ribosomal protein l27 E1B22_02725 ENOG4105X36 (ribosomal) protein E1B22_02730 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) E1B22_02735 ENOG4105C03 ribonuclease E1B22_02745 ENOG4108K5P (LipO)protein E1B22_02750 ENOG4105CNI cell division protein FtsW E1B22_02755 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) E1B22_02760 ENOG4107QMS site-determining protein E1B22_02765 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) E1B22_02770 ENOG4107RF6 penicillin-binding protein E1B22_02780 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E1B22_02785 ENOG4105DFF Rod shape-determining protein mreb E1B22_02790 ENOG4105W5Q DNA repair protein (RadC E1B22_02795 ENOG4108Z03 MAF-like protein E1B22_02805 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) E1B22_02815 ENOG4108IUX (ABC) transporter E1B22_02825 ENOG4108IUQ atp-dependent protease E1B22_02830 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) E1B22_02835 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) E1B22_02840 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation E1B22_02855 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) E1B22_02905 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) E1B22_02915 ENOG4108U5N UPF0316 protein E1B22_02920 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E1B22_02930 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) E1B22_02935 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E1B22_02940 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for E1B22_02945 ENOG4105XZU Preprotein translocase, subunit SecG E1B22_02950 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) E1B22_02955 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) E1B22_02960 ENOG4105CP7 Triose-phosphate isomerase E1B22_02965 ENOG4105BZA Phosphoglycerate kinase E1B22_02980 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase E1B22_02995 ENOG4105C26 Dehydrogenase E1B22_03000 ENOG4105I3K Ferric uptake regulator, Fur family E1B22_03005 ENOG4105C0H protease E1B22_03035 ENOG4105D0U Arsenite-activated ATPase (ArsA) E1B22_03040 ENOG4105D0U Arsenite-activated ATPase (ArsA) E1B22_03050 ENOG4105D22 carbon starvation protein E1B22_03060 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E1B22_03065 ENOG4108UJD 30S ribosomal protein S9 E1B22_03070 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) E1B22_03075 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) E1B22_03080 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) E1B22_03085 ENOG4108JJB ABC transporter E1B22_03090 ENOG4108JJB ABC transporter E1B22_03095 ENOG4108ZT0 50S ribosomal protein l17 E1B22_03100 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E1B22_03105 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) E1B22_03110 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits E1B22_03115 ENOG41067V7 50S ribosomal protein L36 E1B22_03120 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) E1B22_03130 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E1B22_03140 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E1B22_03145 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) E1B22_03150 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) E1B22_03155 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) E1B22_03160 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) E1B22_03165 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) E1B22_03170 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) E1B22_03175 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits E1B22_03180 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) E1B22_03185 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) E1B22_03190 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal E1B22_03195 ENOG41082SA 50s ribosomal protein l29 E1B22_03200 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) E1B22_03205 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) E1B22_03210 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) E1B22_03215 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) E1B22_03220 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity E1B22_03225 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) E1B22_03230 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) E1B22_03235 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) E1B22_03240 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) E1B22_03245 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E1B22_03250 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) E1B22_03255 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) E1B22_03260 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) E1B22_03265 ENOG4105XPM ribosomal protein E1B22_03270 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E1B22_03275 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E1B22_03280 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) E1B22_03285 ENOG4108VZM 50s ribosomal protein L10 E1B22_03290 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) E1B22_03295 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) E1B22_03300 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E1B22_03315 ENOG4105WDJ 50S ribosomal protein L33 E1B22_03320 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E1B22_03345 ENOG4105QIV RNA polymerase E1B22_03350 ENOG4105C2N RNA methyltransferase TrmH family group 3 E1B22_03355 ENOG4105C8N cysteinyl-tRNA synthetase E1B22_03370 ENOG4108EM8 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) E1B22_03375 ENOG4105CTP PilT protein domain protein E1B22_03380 ENOG4108VJ1 Transcriptional regulator (CarD family E1B22_03390 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) E1B22_03395 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) E1B22_03400 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E1B22_03410 ENOG41066A3 ATP guanido phosphotransferase E1B22_03415 ENOG4108Z0C Uvrb UvrC protein E1B22_03430 ENOG4105VF7 tolerance protein E1B22_03435 ENOG4108ZRZ Transcriptional regulator (AsnC family) E1B22_03440 ENOG4108JPW Aminotransferase E1B22_03465 ENOG4105D07 Signal peptide peptidase, SppA E1B22_03470 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) E1B22_03475 ENOG4105C75 arginyL-tRNA synthetase E1B22_03485 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) E1B22_03500 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) E1B22_03510 ENOG4105C0H protease E1B22_03520 ENOG4105E4C Lytic transglycosylase catalytic E1B22_03540 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis E1B22_03545 ENOG4105CDU Replicative dna helicase E1B22_03550 ENOG4105K9Q Binds to the 23S rRNA (By similarity) E1B22_03560 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) E1B22_03565 ENOG4108UUM single-stranded DNA-binding protein E1B22_03570 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) E1B22_03575 ENOG4105VDK protein, conserved in bacteria E1B22_03585 ENOG4108IV0 ABC, transporter E1B22_03590 ENOG4105C0Z ABC transporter E1B22_03595 ENOG4105CF8 branched-chain amino acid ABC transporter, permease E1B22_03600 ENOG4105C32 Amino acid ABC transporter (Permease) E1B22_03605 ENOG4105CP9 extracellular ligand-binding receptor E1B22_03610 ENOG4108ZDA Sporulation protein YyaC E1B22_03625 ENOG4105FA0 parb-like partition protein E1B22_03630 ENOG4107QJE Chromosome Partitioning Protein E1B22_03635 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) E1B22_03640 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) E1B22_03650 ENOG4107R4E Membrane E1B22_03655 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) E1B22_03660 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) E1B22_03665 ENOG4105VG0 50S ribosomal protein l34 E1B22_03670 ENOG4108K9K Uncharacterised protein family (UPF0236) E1B22_03675 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) E1B22_03680 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E1B22_03685 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) E1B22_03700 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E1B22_03705 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E1B22_03710 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) E1B22_03715 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) E1B22_03740 ENOG4105VTR Integrase E1B22_03770 ENOG4105D5G Transposase E1B22_03795 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) E1B22_03805 ENOG410807C QueT transporter E1B22_03820 ENOG4108Z6B deaminase E1B22_03840 ENOG4105C6E dna polymerase iii E1B22_03845 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) E1B22_03850 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) E1B22_03865 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) E1B22_03900 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) E1B22_03905 ENOG4105X0R protein from nitrogen regulatory protein P-II E1B22_03910 ENOG4107QRG dna polymerase iii E1B22_03915 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E1B22_03920 ENOG4105KRN Transcriptional regulator, abrb family E1B22_03930 ENOG4108K9K Uncharacterised protein family (UPF0236) E1B22_03940 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) E1B22_03945 ENOG4105F8V Hydrolase, tatD family E1B22_03950 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) E1B22_03955 ENOG4108XRC Protein of unknown function (DUF458) E1B22_03965 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) E1B22_03975 ENOG4105DFT pur operon repressor E1B22_03980 ENOG4105C7B Threonine dehydratase E1B22_03985 ENOG4105K4W Could be involved in septation (By similarity) E1B22_04000 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) E1B22_04005 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E1B22_04010 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) E1B22_04015 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) E1B22_04025 ENOG4108M14 stage v sporulation protein t E1B22_04030 ENOG4105DXN mazG family E1B22_04075 ENOG4105C3M thioredoxin reductase E1B22_04090 ENOG4108UNV SUF system FeS assembly protein, NifU family E1B22_04095 ENOG4105C9B Cysteine desulfurase E1B22_04100 ENOG4105JRK feS assembly protein SufD E1B22_04105 ENOG4105C3K feS assembly ATPase SufC E1B22_04115 ENOG4105CN9 Peptidase m42 family protein E1B22_04135 ENOG4105E33 succinate dehydrogenase E1B22_04145 ENOG4108WBT adenosyltransferase E1B22_04175 ENOG4105CZA synthase E1B22_04180 ENOG4108Y5D Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase E1B22_04185 ENOG4108RAV Conserved protein E1B22_04215 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) E1B22_04220 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E1B22_04225 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate E1B22_04235 ENOG4105C84 Histidine ammonia-lyase E1B22_04250 ENOG4105KXX peptidase s58 dmpa E1B22_04270 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) E1B22_04275 ENOG4105CRK lysyL-tRNA synthetase E1B22_04320 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E1B22_04325 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E1B22_04330 ENOG4105DR5 peptidase E1B22_04335 ENOG41082DI 50s ribosomal protein l31 E1B22_04340 ENOG4105CBJ Metal-dependent enzyme E1B22_04345 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) E1B22_04350 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E1B22_04355 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) E1B22_04360 ENOG4108YZG isomerase E1B22_04365 ENOG4105ESV Glycosyl transferase, family 4 E1B22_04370 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E1B22_04385 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) E1B22_04390 ENOG41086BG ATP synthase subunit C E1B22_04395 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) E1B22_04400 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) E1B22_04405 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) E1B22_04410 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) E1B22_04415 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) E1B22_04420 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) E1B22_04425 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) E1B22_04435 ENOG4105DR5 peptidase E1B22_04440 ENOG4105MT0 Sporulation transcriptional regulator spoiiid E1B22_04445 ENOG4105DFF Rod shape-determining protein mreb E1B22_04450 ENOG4105BZE flagellar hook protein, FlgE E1B22_04455 ENOG4105CGA flagellar basal-body rod protein FlgG E1B22_04465 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) E1B22_04470 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) E1B22_04475 ENOG4108KP7 hydrolase E1B22_04490 ENOG4107RT6 flagellar hook-associated E1B22_04505 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP E1B22_04515 ENOG4105BZU Histidine kinase E1B22_04520 ENOG4105MJ2 Competence protein E1B22_04545 ENOG4105DTJ flagellar hook-associated protein E1B22_04585 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving E1B22_04595 ENOG4105CAK Cell division ATP-binding protein ftsE E1B22_04600 ENOG4105CRP Part of the ABC transporter FtsEX involved in E1B22_04610 ENOG4105CN1 protease E1B22_04620 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) E1B22_04625 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E1B22_04640 ENOG4105D7V transposase E1B22_04655 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) E1B22_04660 ENOG4105C7K acetolactate synthase E1B22_04675 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) E1B22_04680 ENOG4105D49 3-dehydroquinate synthase E1B22_04690 ENOG4105E2X shikimate dehydrogenase E1B22_04695 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase E1B22_04710 ENOG4105KHN chorismate mutase E1B22_04725 ENOG4105CJW magnesium transporter E1B22_04740 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) E1B22_04745 ENOG4105CHW UPF0052 protein E1B22_04750 ENOG4105CIE May be required for sporulation (By similarity) E1B22_04760 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) E1B22_04765 ENOG4105C8B TIGR00159 family E1B22_04775 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) E1B22_04780 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E1B22_04790 ENOG4105CJ1 ABC, transporter E1B22_04800 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) E1B22_04810 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) E1B22_04825 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase E1B22_04835 ENOG41080HT Transcriptional regulator, arsr family E1B22_04840 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) E1B22_04850 ENOG4105D5G Transposase E1B22_04855 ENOG4105VFE sira family E1B22_04860 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase E1B22_04865 ENOG41087NI Sulfite exporter TauE/SafE E1B22_04890 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) E1B22_04895 ENOG4107RQ2 Cytochrome c oxidase, subunit I E1B22_04900 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) E1B22_04905 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E1B22_04910 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E1B22_04920 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) E1B22_04935 ENOG4105K8N protein family UPF0079, ATPase E1B22_04940 ENOG41072GX Peptidase M22 Glycoprotease E1B22_04945 ENOG410801F ribosomal-protein-alanine acetyltransferase E1B22_04950 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) E1B22_04955 ENOG4108S4C acetyltransferase E1B22_04960 ENOG4105DFU Cell wall formation (By similarity) E1B22_04965 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E1B22_04970 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E1B22_04980 ENOG4105CVM Molybdenum cofactor synthesis domain protein E1B22_04985 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) E1B22_04990 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) E1B22_04995 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) E1B22_05000 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) E1B22_05005 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E1B22_05010 ENOG4105BZU Histidine kinase E1B22_05025 ENOG4105C3U ABC transporter E1B22_05030 ENOG4108JQ7 (ABC) transporter E1B22_05040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E1B22_05045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E1B22_05055 ENOG4108JQ7 (ABC) transporter E1B22_05065 ENOG4105D7V transposase E1B22_05080 ENOG4105C09 Bile acid E1B22_05085 ENOG4105DC7 peptidase M24 E1B22_05090 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) E1B22_05095 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) E1B22_05100 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) E1B22_05105 ENOG4105BZS acriflavin resistance protein E1B22_05110 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) E1B22_05115 ENOG4105F0I Aminotransferase E1B22_05135 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E1B22_05140 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain E1B22_05145 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E1B22_05150 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) E1B22_05155 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E1B22_05170 ENOG4105D65 subunit l E1B22_05175 ENOG4105C8S subunit m E1B22_05180 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E1B22_05185 ENOG4107YZX Universal stress protein E1B22_05190 ENOG4107RWR Sodium hydrogen exchanger E1B22_05200 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) E1B22_05220 ENOG4105D7V transposase E1B22_05230 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) E1B22_05235 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E1B22_05240 ENOG4105C8Q Methyl-accepting chemotaxis E1B22_05245 ENOG4105CHR reductase E1B22_05250 ENOG4108UZ3 Transporter E1B22_05275 ENOG4108UGV hypoxanthine phosphoribosyltransferase E1B22_05280 ENOG4108K9K Uncharacterised protein family (UPF0236) E1B22_05300 ENOG4105C7R Atpase associated with various cellular activities aaa_3 E1B22_05305 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) E1B22_05310 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E1B22_05320 ENOG4105PTM secreted protein E1B22_05325 ENOG4107T5V SNARE associated Golgi E1B22_05350 ENOG4108RQ5 Beta-lactamase domain-containing protein E1B22_05355 ENOG4105CHM Aminotransferase E1B22_05360 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) E1B22_05375 ENOG4105ETE Transcriptional regulator (LacI family E1B22_05380 ENOG4108RVA ribokinase E1B22_05385 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) E1B22_05390 ENOG4105C2J ABC transporter E1B22_05395 ENOG4105CNN ABC, transporter E1B22_05400 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E1B22_05410 ENOG4105ZU5 s-layer protein E1B22_05440 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) E1B22_05445 ENOG4108Y6J UPF0403 protein E1B22_05455 ENOG410635A Membrane E1B22_05485 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) E1B22_05490 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) E1B22_05500 ENOG4105ED1 spovr family E1B22_05505 ENOG4105CYN Serine protein kinase E1B22_05520 ENOG4105CTQ phosphohexokinase E1B22_05530 ENOG4105D1F ATP-binding protein E1B22_05540 ENOG4105D5G Transposase E1B22_05545 ENOG4105D5G Transposase E1B22_05550 ENOG4105CFH Aspartokinase E1B22_05570 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase E1B22_05585 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving E1B22_05605 ENOG4105CK1 PTS System E1B22_05610 ENOG4105VCP PTS System E1B22_05620 ENOG4105F2C Acetyl-CoA acetyltransferase E1B22_05630 ENOG4105CEY Amp-dependent synthetase and ligase E1B22_05650 ENOG4105CPQ Dehydrogenase E1B22_05655 ENOG4105G2U Cupin 2, conserved barrel domain protein E1B22_05675 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) E1B22_05680 ENOG4105Z4T Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) E1B22_05685 ENOG4105BZ9 Cytochrome C oxidase, subunit I E1B22_05695 ENOG4105CCU oxidase (Subunit III) E1B22_05710 ENOG4105K4I Scp-like extracellular E1B22_05720 ENOG4105FAA peptidase M23 E1B22_05785 ENOG4105F0V Cell wall hydrolase E1B22_05795 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E1B22_05815 ENOG4105WCJ ec 1.1.1.193 E1B22_05820 ENOG4105EEI dihydropteroate synthase E1B22_05825 ENOG4107EXU Short-chain dehydrogenase reductase Sdr E1B22_05835 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase E1B22_05850 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E1B22_05855 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E1B22_05860 ENOG41086CI Bifunctional phosphoglucose phosphomannose isomerase E1B22_05895 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase E1B22_05905 ENOG4105KV4 Transcriptional regulator E1B22_05910 ENOG4105C5F glutamine synthetase E1B22_05925 ENOG4107QZ7 Cellulose synthase catalytic subunit E1B22_05935 ENOG4105BZ1 (ABC) transporter E1B22_05960 ENOG4105CBT Fructose-1,6-bisphosphatase E1B22_05970 ENOG4107R7Y intracellular protease Pfpi family E1B22_05980 ENOG4105DTQ mandelate racemase muconate lactonizing E1B22_06020 ENOG4105BZJ Electron transfer flavoprotein E1B22_06025 ENOG4105C10 Electron transfer flavoprotein E1B22_06030 ENOG4105DF6 Fe-S oxidoreductase E1B22_06035 ENOG4105CEY Amp-dependent synthetase and ligase E1B22_06060 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component E1B22_06095 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) E1B22_06125 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component E1B22_06140 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) E1B22_06150 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for E1B22_06155 ENOG4108VCA G U mismatch-specific DNA glycosylase E1B22_06165 ENOG4105C0R drug resistance transporter emrb qaca subfamily E1B22_06170 ENOG4108VNY MOSC domain protein E1B22_06180 ENOG4105DKQ ROK family E1B22_06190 ENOG4105EMN RNA polymerase sigma factor E1B22_06210 ENOG4105CJ1 ABC, transporter E1B22_06240 ENOG4105E39 Enoyl-CoA hydratase E1B22_06245 ENOG4108RMH femAB family E1B22_06250 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E1B22_06255 ENOG4105CTD carboxy-peptidase E1B22_06265 ENOG4105C0R drug resistance transporter emrb qaca subfamily E1B22_06275 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) E1B22_06280 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) E1B22_06285 ENOG4107ZYJ bioY protein E1B22_06290 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase E1B22_06295 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) E1B22_06310 ENOG4105DBV ornithine carbamoyltransferase E1B22_06325 ENOG4105CH7 arginosuccinase E1B22_06380 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase E1B22_06385 ENOG4108HQS Glycine betaine E1B22_06400 ENOG4108TN2 lmbE family E1B22_06430 ENOG4105MYN Zinc uptake regulation protein E1B22_06435 ENOG4105FDK ABC transporter E1B22_06440 ENOG4105FAV ABC, transporter E1B22_06445 ENOG4105DSE periplasmic solute binding protein E1B22_06450 ENOG4105EU0 Major facilitator Superfamily E1B22_06500 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein E1B22_06510 ENOG4105E4C Lytic transglycosylase catalytic E1B22_06515 ENOG4105D01 (LipO)protein E1B22_06520 ENOG4108UMI ABC transporter, permease E1B22_06530 ENOG4105CAQ asparagine synthetase E1B22_06540 ENOG4105C0Z ABC transporter E1B22_06545 ENOG4108IV0 ABC, transporter E1B22_06555 ENOG4108IPJ Membrane E1B22_06565 ENOG4105D17 glycoside hydrolase, family 3 domain protein E1B22_06570 ENOG4105EHZ conserved protein UCP016719 E1B22_06585 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate E1B22_06590 ENOG4105FDP GntR family transcriptional regulator E1B22_06595 ENOG4105CE4 GlcNAc 6-P deacetylase E1B22_06605 ENOG410667J hydrolase E1B22_06610 ENOG41062BK proline dehydrogenase E1B22_06615 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E1B22_06620 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) E1B22_06625 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase E1B22_06635 ENOG4105ECC imidazole-glycerol-phosphate dehydratase E1B22_06640 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) E1B22_06645 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) E1B22_06655 ENOG4105F76 Sarcosine oxidase E1B22_06700 ENOG4106678 morphogenetic protein associated with SpoVID E1B22_06715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E1B22_06750 ENOG4105CPQ Dehydrogenase E1B22_06755 ENOG4108K9K Uncharacterised protein family (UPF0236) E1B22_06765 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) E1B22_06775 ENOG4105C4K Nad synthetase E1B22_06780 ENOG4105D64 Mechanosensitive ion channel E1B22_06785 ENOG4107RVG penicillin-binding protein E1B22_06805 ENOG4105C5F glutamine synthetase E1B22_06820 ENOG4105CAQ asparagine synthetase E1B22_06835 ENOG4105EBR Carboxylesterase E1B22_06870 ENOG4105JNK Glycosyl transferase (Group 1 E1B22_06875 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family E1B22_06890 ENOG4105JFG SpoIID LytB domain protein E1B22_06900 ENOG4107GBW cellulosome anchoring protein cohesin E1B22_06930 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) E1B22_06935 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) E1B22_06950 ENOG4108S0S Nucleotidyl transferase E1B22_06960 ENOG4105CJR Integral membrane protein (MviN E1B22_06970 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E1B22_06980 ENOG4105CGP Urocanate hydratase E1B22_06990 ENOG4105CI2 imidazolone-5-propionate hydrolase E1B22_06995 ENOG4105CZ9 Domain of unknown function (DU1801) E1B22_07000 ENOG4105CYW agmatinase E1B22_07005 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E1B22_07025 ENOG4105CZX twitching motility protein E1B22_07030 ENOG4106A3R peptidase E1B22_07035 ENOG4107QHF type ii secretion system protein e E1B22_07045 ENOG4108ZUW Major pilin subunit E1B22_07100 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E1B22_07110 ENOG4105CJR Integral membrane protein (MviN E1B22_07115 ENOG4105E14 MotA TolQ exbB proton channel E1B22_07120 ENOG4106VK6 Flagellar motor protein E1B22_07125 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase E1B22_07140 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) E1B22_07155 ENOG4105D3Q Sugar transferase E1B22_07165 ENOG4107XU6 Glycosyl transferase (Group 1 E1B22_07175 ENOG4105HTX biosynthesis protein E1B22_07180 ENOG4107YJ4 chain length determinant protein E1B22_07185 ENOG4105K64 Glycosyl transferase, family 2 E1B22_07190 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) E1B22_07205 ENOG4105D5G Transposase E1B22_07215 ENOG4105C6Y Udp-glucose 6-dehydrogenase E1B22_07220 ENOG4105C1B dTDP-glucose 4-6-dehydratase E1B22_07240 ENOG4105C5R Aminotransferase E1B22_07265 ENOG4105C1G acyl-Coa dehydrogenase E1B22_07290 ENOG4108KGH TRANSCRIPTIONal E1B22_07295 ENOG4105BZU Histidine kinase E1B22_07305 ENOG4105CHR reductase E1B22_07315 ENOG4105BZG amino acid carrier protein E1B22_07325 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E1B22_07335 ENOG4108K88 Membrane E1B22_07355 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E1B22_07365 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) E1B22_07375 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) E1B22_07385 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) E1B22_07395 ENOG4108HQS Glycine betaine E1B22_07405 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) E1B22_07410 ENOG4105C1Q protoporphyrinogen oxidase E1B22_07425 ENOG4105ETX regulatoR E1B22_07430 ENOG41062D9 Histidine kinase E1B22_07435 ENOG4107S21 permease E1B22_07440 ENOG4105CBC glutamate synthase E1B22_07495 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) E1B22_07505 ENOG4106D4I domain protein E1B22_07510 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination E1B22_07530 ENOG4105CHR reductase E1B22_07535 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase E1B22_07550 ENOG4105C7N Xanthine uracil vitamin C permease E1B22_07575 ENOG4105WH1 Two component transcriptional regulator luxr family E1B22_07650 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E1B22_07675 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 E1B22_07680 ENOG4108VCT Sulfite exporter TauE/SafE E1B22_07690 ENOG4108VMM UPF0756 membrane protein E1B22_07700 ENOG41083MR nifu domain-containing protein E1B22_07725 ENOG4105DPN Oligoendopeptidase f E1B22_07730 ENOG4108K9K Uncharacterised protein family (UPF0236) E1B22_07750 ENOG4105C0H protease E1B22_07755 ENOG4108XFG YwhD family E1B22_07765 ENOG4106MP8 UPF0754 membrane protein E1B22_07770 ENOG4105C22 threonyL-tRNA synthetase E1B22_07775 ENOG4105DEF Extracellular solute-binding protein, family 5 E1B22_07780 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E1B22_07785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E1B22_07790 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) E1B22_07795 ENOG41082NX 50s ribosomal protein l35 E1B22_07800 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) E1B22_07805 ENOG4105CZN Potassium uptake protein E1B22_07810 ENOG4107ZYR domain protein E1B22_07825 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) E1B22_07830 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E1B22_07840 ENOG4105DCG PHP domain protein E1B22_07845 ENOG4105C98 muts2 protein E1B22_07855 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) E1B22_07865 ENOG4105C6T cysteine synthase E1B22_07870 ENOG4105CDY transcriptional regulatory protein E1B22_07880 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) E1B22_07885 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) E1B22_07890 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) E1B22_07895 ENOG41061AI Protein of unknown function (DUF2905) E1B22_07900 ENOG4108WZW RNA polymerase sigma E1B22_07910 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) E1B22_07915 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) E1B22_07920 ENOG4105VIE preprotein translocase, subunit YajC E1B22_07930 ENOG4107QX3 carboxylase E1B22_07940 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein E1B22_07945 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase E1B22_07955 ENOG4108V6E Cell division protein mraZ E1B22_07960 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) E1B22_07975 ENOG4105CJN penicillin-binding protein E1B22_07990 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) E1B22_07995 ENOG4105CNI cell division protein FtsW E1B22_08005 ENOG4105D4A Cell wall formation (By similarity) E1B22_08015 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E1B22_08030 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E1B22_08050 ENOG4105WR5 sporulation protein, YlmC YmxH family E1B22_08060 ENOG4105DFA alanine racemase domain protein E1B22_08065 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) E1B22_08070 ENOG4108VIA integral membrane protein E1B22_08080 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) E1B22_08090 ENOG4105EFZ amidohydrolase E1B22_08095 ENOG4107NFR Fructose-1,6-bisphosphatase E1B22_08110 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) E1B22_08115 ENOG4105C34 Pseudouridine synthase E1B22_08120 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) E1B22_08125 ENOG4105BZW Glycerate kinase E1B22_08130 ENOG4105F23 Fibronectin-binding protein E1B22_08140 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component E1B22_08145 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component E1B22_08155 ENOG4105ETE Transcriptional regulator (LacI family E1B22_08165 ENOG4105CHU acetyl-coa acetyltransferase E1B22_08170 ENOG4105C1G acyl-Coa dehydrogenase E1B22_08175 ENOG41069FQ Metallo-beta-lactamase superfamily E1B22_08180 ENOG4105CD5 CoA-binding domain protein E1B22_08220 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) E1B22_08225 ENOG4105CHM Aminotransferase E1B22_08235 ENOG4105DSJ YicC domain protein E1B22_08240 ENOG4105KC4 UPF0296 protein E1B22_08245 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E1B22_08250 ENOG41084KE Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) E1B22_08255 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E1B22_08260 ENOG4105C25 Primosomal protein n' E1B22_08265 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) E1B22_08275 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E1B22_08280 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs E1B22_08285 ENOG4108ZF3 Phosphatase E1B22_08290 ENOG4105D9P serine threonine protein kinase E1B22_08300 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) E1B22_08305 ENOG4105DJV ribulose-phosphate 3-epimerase E1B22_08310 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) E1B22_08315 ENOG4105VB9 50S ribosomal protein l28 E1B22_08335 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) E1B22_08340 ENOG4107RCC Major Facilitator Superfamily E1B22_08350 ENOG4106H78 methyltransferase E1B22_08355 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) E1B22_08365 ENOG4105H20 Sporulation integral membrane protein YlbJ E1B22_08380 ENOG41067VY 50S ribosomal protein L32 E1B22_08390 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) E1B22_08400 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E1B22_08405 ENOG4105CHR reductase E1B22_08410 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) E1B22_08415 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E1B22_08420 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) E1B22_08430 ENOG4105MCT stage V sporulation protein S E1B22_08435 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) E1B22_08440 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E1B22_08445 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) E1B22_08455 ENOG4105K5M 30s ribosomal protein S16 E1B22_08460 ENOG4105VB6 UPF0109 protein E1B22_08465 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) E1B22_08470 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) E1B22_08475 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) E1B22_08485 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) E1B22_08495 ENOG410850P UPF0102 protein E1B22_08500 ENOG4105C0P Mg chelatase subunit ChlI E1B22_08505 ENOG4108J59 Extracellular solute-binding protein, family 5 E1B22_08515 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E1B22_08530 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) E1B22_08535 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) E1B22_08540 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) E1B22_08545 ENOG4108ZC9 flagellar basal-body rod protein flgc E1B22_08555 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) E1B22_08560 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E1B22_08590 ENOG4108JQA flagellar E1B22_08605 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E1B22_08610 ENOG4105DD5 Flagellar motor switch protein E1B22_08625 ENOG4105CN7 Flagellar biosynthetic protein FliP E1B22_08630 ENOG4105VS8 Flagellar biosynthetic protein fliq E1B22_08635 ENOG4105D19 Role in flagellar biosynthesis (By similarity) E1B22_08640 ENOG4105D00 flagellar biosynthetic protein flhB E1B22_08645 ENOG4105D7B Flagellar biosynthesis protein flha E1B22_08650 ENOG4105FZW flagellar biosynthesis regulator FlhF E1B22_08665 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E1B22_08680 ENOG4108K9K Uncharacterised protein family (UPF0236) E1B22_08685 ENOG4105CE9 30S ribosomal protein S2 E1B22_08690 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) E1B22_08695 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) E1B22_08700 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) E1B22_08715 ENOG4105KNE Phosphatidate cytidylyltransferase E1B22_08720 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) E1B22_08725 ENOG4105DZP Membrane-associated zinc metalloprotease E1B22_08730 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) E1B22_08735 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) E1B22_08745 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) E1B22_08750 ENOG4105CHV Transcription elongation factor NusA E1B22_08755 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination E1B22_08765 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) E1B22_08775 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) E1B22_08785 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) E1B22_08790 ENOG4105DTN riboflavin biosynthesis protein ribF E1B22_08795 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) E1B22_08800 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) E1B22_08805 ENOG4105C1V Peptidase, M16 E1B22_08810 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) E1B22_08825 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) E1B22_08835 ENOG4108S0H Dipicolinic acid synthetase, b subunit E1B22_08840 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E1B22_08850 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E1B22_08855 ENOG4105CN5 Metallo-Beta-Lactamase E1B22_08860 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit E1B22_08870 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) E1B22_08875 ENOG4105CNU cell division protein FtsK E1B22_08880 ENOG4105VRS hydrolase family 18 E1B22_08905 ENOG4105C1G acyl-Coa dehydrogenase E1B22_08910 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase E1B22_08915 ENOG4105DZ1 carboxypeptidase E1B22_08920 ENOG4105C5S asparaginyl-tRNA synthetase E1B22_08925 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) E1B22_08930 ENOG4105DZ1 carboxypeptidase E1B22_08935 ENOG4108NMV polysaccharide deacetylase E1B22_08945 ENOG4108I5C dEAD DEAH box helicase E1B22_08950 ENOG41074B2 UPF0747 protein E1B22_08955 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein E1B22_08965 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E1B22_08970 ENOG4105CEV competence damage-inducible protein E1B22_08975 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E1B22_08985 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) E1B22_08990 ENOG410902V Modulates RecA activity (By similarity) E1B22_08995 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) E1B22_09000 ENOG4105D48 metallophosphoesterase E1B22_09005 ENOG4108IGT Dipeptidase E1B22_09010 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) E1B22_09015 ENOG4105DB7 PHP domain protein E1B22_09030 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) E1B22_09035 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) E1B22_09040 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) E1B22_09045 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) E1B22_09060 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control E1B22_09065 ENOG4106F1P AAA ATPase, central domain protein E1B22_09070 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E1B22_09080 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) E1B22_09095 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E1B22_09115 ENOG4108ZJ4 polysaccharide deacetylase E1B22_09125 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) E1B22_09130 ENOG4105CVJ phosphoglycerate mutase E1B22_09135 ENOG4105C5I Dehydrogenase E1B22_09140 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) E1B22_09145 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) E1B22_09150 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) E1B22_09155 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) E1B22_09160 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) E1B22_09170 ENOG4105Q84 sucrose synthase E1B22_09180 ENOG4105D06 uba thif-type nad fad binding protein E1B22_09195 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) E1B22_09205 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) E1B22_09210 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) E1B22_09225 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E1B22_09230 ENOG4105CEY Amp-dependent synthetase and ligase E1B22_09235 ENOG4105CAT Cytidine monophosphate kinase E1B22_09260 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E1B22_09265 ENOG4105C10 Electron transfer flavoprotein E1B22_09270 ENOG4105BZJ Electron transfer flavoprotein E1B22_09275 ENOG4105RFZ Methylmalonyl-coA mutase E1B22_09280 ENOG4105FE9 pseudouridine synthase E1B22_09295 ENOG4108JIC nucleoside recognition domain protein E1B22_09300 ENOG4105C0D helicase E1B22_09310 ENOG4105GN4 DNA ligase E1B22_09315 ENOG4105FDF Could be involved in DNA repair (By similarity) E1B22_09320 ENOG4105KBJ sporulation protein ytfj E1B22_09330 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) E1B22_09335 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) E1B22_09340 ENOG4108Z4T Peptidase M50 E1B22_09355 ENOG4105CZ3 stage V sporulation protein ad E1B22_09360 ENOG41090VF Stage v sporulation protein ac E1B22_09375 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) E1B22_09385 ENOG4105DZ1 carboxypeptidase E1B22_09390 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) E1B22_09400 ENOG4105DCF alanine dehydrogenase E1B22_09410 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) E1B22_09435 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) E1B22_09455 ENOG4107QQR Sporulation E1B22_09465 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E1B22_09470 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) E1B22_09475 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) E1B22_09485 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E1B22_09490 ENOG4105DX0 Hemolysin A E1B22_09500 ENOG4105CTB Polyprenyl synthetase E1B22_09510 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E1B22_09515 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) E1B22_09535 ENOG4108ZSR alkaline shock protein E1B22_09560 ENOG4105KQ4 Stage iii sporulation protein ad E1B22_09565 ENOG4108CQH stage III sporulation protein AC E1B22_09585 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) E1B22_09590 ENOG4105DC7 peptidase M24 E1B22_09600 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) E1B22_09605 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor E1B22_09610 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor E1B22_09615 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) E1B22_09620 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) E1B22_09635 ENOG4105BZF Glycosyl transferase (Group 1 E1B22_09645 ENOG4105D5G Transposase E1B22_09705 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase E1B22_09710 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E1B22_09715 ENOG4105HHA aminodeoxychorismate lyase E1B22_09720 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) E1B22_09735 ENOG4105VBH UPF0297 protein E1B22_09740 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) E1B22_09770 ENOG4107QI6 Cysteine desulfurase E1B22_09785 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) E1B22_09790 ENOG4107104 thymidine kinase E1B22_09805 ENOG4105K63 Thioredoxin E1B22_09815 ENOG4105C9M aspartyl-trna synthetase E1B22_09820 ENOG4105CUT histidyl-tRNA synthetase E1B22_09825 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) E1B22_09830 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E1B22_09835 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E1B22_09850 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E1B22_09855 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E1B22_09870 ENOG4105EM7 Selenocysteine-specific translation elongation factor E1B22_09880 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) E1B22_09885 ENOG4108K9K Uncharacterised protein family (UPF0236) E1B22_09900 ENOG4105C1G acyl-Coa dehydrogenase E1B22_09920 ENOG4105D52 delta-aminolevulinic acid dehydratase E1B22_09925 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E1B22_09930 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) E1B22_09940 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) E1B22_09945 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) E1B22_09950 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E1B22_09955 ENOG4105CMV Succinyl-CoA synthetase subunit beta E1B22_09960 ENOG4105C6K Malic enzyme E1B22_09965 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) E1B22_09975 ENOG41060IM Heme exporter protein E1B22_09980 ENOG4105CJ1 ABC, transporter E1B22_09990 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) E1B22_10000 ENOG4108M14 stage v sporulation protein t E1B22_10005 ENOG4105VBH UPF0297 protein E1B22_10020 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) E1B22_10025 ENOG4108JJB ABC transporter E1B22_10030 ENOG4107QI6 Cysteine desulfurase E1B22_10035 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) E1B22_10045 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E1B22_10070 ENOG4105D6E homoserine dehydrogenase E1B22_10075 ENOG4105DWV Homoserine O-trans-acetylase E1B22_10080 ENOG4105CIG ABC transporter E1B22_10090 ENOG4105EMN RNA polymerase sigma factor E1B22_10100 ENOG4105DA5 (ABC) transporter E1B22_10125 ENOG4105PW4 Sugar fermentation stimulation protein homolog E1B22_10130 ENOG4106KNT transcriptional regulator E1B22_10140 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E1B22_10170 ENOG4105BZN citrate synthase E1B22_10175 ENOG4105E0A ABC, transporter E1B22_10180 ENOG4105EHG Permease protein E1B22_10185 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) E1B22_10190 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E1B22_10200 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E1B22_10215 ENOG4108IG5 Transcriptional regulator E1B22_10220 ENOG4105D7V transposase E1B22_10225 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E1B22_10235 ENOG4105DIH basic membrane E1B22_10240 ENOG4108JQ9 ABC transporter E1B22_10245 ENOG4105UIB (ABC) transporter E1B22_10255 ENOG4105BZ1 (ABC) transporter E1B22_10260 ENOG4105BZ1 (ABC) transporter E1B22_10275 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E1B22_10280 ENOG4105DIN metallophosphoesterase E1B22_10285 ENOG4105ETU transcriptional activator (TenA E1B22_10290 ENOG4108JJB ABC transporter E1B22_10295 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein E1B22_10300 ENOG4105CHR reductase E1B22_10310 ENOG4105CEY Amp-dependent synthetase and ligase E1B22_10340 ENOG410667J hydrolase E1B22_10350 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E1B22_10355 ENOG4105ERH Fumarylacetoacetate hydrolase E1B22_10365 ENOG4105CUC YeeE YedE family protein E1B22_10375 ENOG4105BZU Histidine kinase E1B22_10380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E1B22_10395 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) E1B22_10405 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) E1B22_10425 ENOG4108Z5K methylglyoxal synthase E1B22_10435 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein E1B22_10440 ENOG4105DQU oxidoreductase, subunit beta E1B22_10455 ENOG4105WH1 Two component transcriptional regulator luxr family E1B22_10460 ENOG4105BZU Histidine kinase E1B22_10470 ENOG4108UMN azlc family E1B22_10495 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) E1B22_10500 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) E1B22_10525 ENOG4105ETE Transcriptional regulator (LacI family E1B22_10535 ENOG4105ETX regulatoR E1B22_10540 ENOG4107QX3 carboxylase E1B22_10545 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit E1B22_10550 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) E1B22_10560 ENOG4105EUJ GTP cyclohydrolase i E1B22_10580 ENOG4107QP3 malate synthase g E1B22_10590 ENOG4105CQB FAD linked oxidase domain protein E1B22_10595 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) E1B22_10600 ENOG4105CQB FAD linked oxidase domain protein E1B22_10610 ENOG4108QXE glycerophosphoryl diester phosphodiesterase E1B22_10615 ENOG4105E1F short-chain dehydrogenase reductase E1B22_10620 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding E1B22_10625 ENOG4105C7W Xanthine dehydrogenase E1B22_10665 ENOG4107R39 (ABC) transporter E1B22_10690 ENOG4107Z3H Transcriptional regulator, TetR family E1B22_10700 ENOG4108Q5U germination protein, ger(x)c family E1B22_10715 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) E1B22_10720 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) E1B22_10725 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E1B22_10730 ENOG4105C12 Phosphoribosylglycinamide synthetase E1B22_10735 ENOG4105DC1 bifunctional purine biosynthesis protein purh E1B22_10770 ENOG4105C8V SAICAR synthetase E1B22_10810 ENOG4105DQU oxidoreductase, subunit beta E1B22_10815 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein E1B22_10825 ENOG4105CDA abc transporter atp-binding protein E1B22_10830 ENOG4105DRP amino acid AbC transporter E1B22_10835 ENOG4105EZ7 amino acid ABC transporter E1B22_10840 ENOG4107QXX ABC transporter E1B22_10845 ENOG4105II7 pyrroline-5-carboxylate reductase E1B22_10850 ENOG4105KZX Pterin carbinolamine dehydratase E1B22_10865 ENOG4105ECP epimerase E1B22_10890 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) E1B22_10895 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) E1B22_10900 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase E1B22_10905 ENOG4105DK0 Indole-3-glycerol phosphate synthase E1B22_10910 ENOG4108I0Q anthranilate phosphoribosyltransferase E1B22_10945 ENOG4105CVM Molybdenum cofactor synthesis domain protein E1B22_10950 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) E1B22_10955 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) E1B22_10960 ENOG4105DZS Phenylacetate-CoA ligase E1B22_10980 ENOG4105DEF Extracellular solute-binding protein, family 5 E1B22_10995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E1B22_11000 ENOG4105CAH Chromate E1B22_11005 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E1B22_11015 ENOG4108JQ7 (ABC) transporter E1B22_11025 ENOG4105E39 Enoyl-CoA hydratase E1B22_11030 ENOG4107RDB Major Facilitator E1B22_11035 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein E1B22_11040 ENOG4105DQU oxidoreductase, subunit beta E1B22_11055 ENOG4105KWG Pfam:DUF1696 E1B22_11090 ENOG4105K64 Glycosyl transferase, family 2 E1B22_11095 ENOG4105D1F ATP-binding protein E1B22_11100 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) E1B22_11105 ENOG4105RRV Inherit from COG: copper resistance E1B22_11115 ENOG4105D7V transposase E1B22_11120 ENOG4108Z4U Ferredoxin E1B22_11140 ENOG4105D7V transposase E1B22_11145 ENOG41090T1 Membrane E1B22_11150 ENOG4105C26 Dehydrogenase E1B22_11160 ENOG4105E2A Dehydrogenase E1B22_11170 ENOG4108IG5 Transcriptional regulator E1B22_11175 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) E1B22_11190 ENOG4105CEY Amp-dependent synthetase and ligase E1B22_11205 ENOG4108RVA ribokinase E1B22_11210 ENOG4108RVA ribokinase E1B22_11215 ENOG4105D7K pfkb domain protein E1B22_11220 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) E1B22_11230 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E1B22_11235 ENOG4105E2R ROK family E1B22_11245 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component E1B22_11250 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component E1B22_11270 ENOG4105D5G Transposase E1B22_11295 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) E1B22_11300 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) E1B22_11320 ENOG4105FB9 CRISPR-associated protein E1B22_11335 ENOG4107QSE Dipeptidase E1B22_11345 ENOG4105E5Q amino acid AbC transporter E1B22_11350 ENOG4105EAB amino acid AbC transporter E1B22_11360 ENOG4105C9B Cysteine desulfurase E1B22_11370 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F E1B22_11375 ENOG4105C0D helicase E1B22_11380 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E1B22_11385 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) E1B22_11395 ENOG4105VPX protein, conserved in bacteria E1B22_11400 ENOG4105C59 p-type ATPase E1B22_11425 ENOG4105D5G Transposase E1B22_11430 ENOG4105EB3 Histidine kinase E1B22_11435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E1B22_11440 ENOG4107R16 Multicopper oxidase E1B22_11450 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E1B22_11455 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase E1B22_11475 ENOG4105C59 p-type ATPase E1B22_11505 ENOG4105BZU Histidine kinase E1B22_11515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E1B22_11520 ENOG4105CEY Amp-dependent synthetase and ligase E1B22_11545 ENOG4105DPZ Two component transcriptional regulator (Winged helix family E1B22_11575 ENOG4105CQB FAD linked oxidase domain protein E1B22_11585 ENOG4108IPT Naphthoate synthase E1B22_11590 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) E1B22_11605 ENOG4105E4F Isochorismate synthase E1B22_11645 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) E1B22_11655 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E1B22_11660 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) E1B22_11675 ENOG4107RIQ Sulfate adenylate transferase E1B22_11680 ENOG4108RWI nicotinamidase E1B22_11685 ENOG4105DPZ Two component transcriptional regulator (Winged helix family E1B22_11690 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E1B22_11695 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E1B22_11715 ENOG4105CMT Dihydroxyacetone kinase E1B22_11720 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E1B22_11730 ENOG4108UXE Protein tyrosine phosphatase E1B22_11735 ENOG4108UTW Plays a role in the regulation of phosphate uptake E1B22_11740 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) E1B22_11745 ENOG4105E2Z phosphate ABC transporter (Permease E1B22_11750 ENOG4105C8U phosphate abc transporter E1B22_11760 ENOG4105BZU Histidine kinase E1B22_11770 ENOG4105KJJ Uncharacterized ACR, COG1993 E1B22_11775 ENOG4105WMR Protein CrcB homolog E1B22_11780 ENOG4105DU1 integral membrane protein, terc E1B22_11785 ENOG4105C9Q fumarate hydratase class II E1B22_11810 ENOG4108QY0 Membrane E1B22_11815 ENOG4108UK2 deaminase E1B22_11825 ENOG4105C5X domain protein E1B22_11845 ENOG4105KZD Domain of unknown function (DUF1805) E1B22_11850 ENOG4108SAX Membrane E1B22_11875 ENOG4105CPP Dehydrogenase, E1 component E1B22_11895 ENOG4105C0D helicase E1B22_11915 ENOG41080V3 Major Facilitator superfamily E1B22_11925 ENOG41080V3 Major Facilitator superfamily E1B22_11935 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E1B22_11940 ENOG4107QM5 aconitate hydratase E1B22_11950 ENOG4108Z4U Ferredoxin E1B22_11955 ENOG4105CN9 Peptidase m42 family protein E1B22_11960 ENOG4105CN9 Peptidase m42 family protein E1B22_11985 ENOG4105CI1 PTS System E1B22_11990 ENOG4105CI1 PTS System E1B22_11995 ENOG4105C5Y PTS System E1B22_12005 ENOG4108Z3G 3H domain protein E1B22_12030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E1B22_12045 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E1B22_12065 ENOG41082BM Transcriptional regulator, arsr family E1B22_12095 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) E1B22_12100 ENOG4105P8F nudix hydrolase E1B22_12110 ENOG4105K6S Short-chain dehydrogenase reductase Sdr E1B22_12120 ENOG4107QR9 Iron-sulfur cluster binding protein E1B22_12140 ENOG4105CJ1 ABC, transporter E1B22_12260 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E1B22_12280 ENOG4105D7V transposase E1B22_12290 ENOG4105D5G Transposase E1B22_12300 ENOG4105CIH Imidazole acetol-phosphate transaminase E1B22_12305 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) E1B22_12310 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) E1B22_12325 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E1B22_12330 ENOG4105D5G Transposase E1B22_12335 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E1B22_12350 ENOG4107QJE Chromosome Partitioning Protein E1B22_12360 ENOG4105FA0 parb-like partition protein E1B22_12380 ENOG4105D5G Transposase E1B22_12405 ENOG4105D5G Transposase E1B22_12410 ENOG4105CIG ABC transporter E1B22_12460 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E1B22_12480 ENOG4105D7V transposase E1B22_12490 ENOG4105D5G Transposase E1B22_12500 ENOG4105CIH Imidazole acetol-phosphate transaminase E1B22_12510 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) E1B22_12535 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E1B22_12555 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E1B22_12595 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)