locus-tag	class	description
E1B22_00025	COG0640	Transcriptional regulator
E1B22_00050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E1B22_00055	COG0494	nUDIX hydrolase
E1B22_00065	COG1028	Short-chain dehydrogenase reductase Sdr
E1B22_00075	COG1139	Iron-sulfur cluster binding protein
E1B22_00095	COG1131	(ABC) transporter
E1B22_00145	COG0028	Belongs to the TPP enzyme family
E1B22_00150	COG0069	glutamate synthase activity
E1B22_00150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E1B22_00155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E1B22_00190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E1B22_00210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E1B22_00220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E1B22_00250	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
E1B22_00255	COG0145	ligase activity
E1B22_00260	COG4647	ligase activity
E1B22_00265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E1B22_00270	COG3284	Transcriptional regulator
E1B22_00295	COG0463	Glycosyl transferase, family 2
E1B22_00335	COG3608	succinylglutamate desuccinylase aspartoacylase
E1B22_00335	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E1B22_00340	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E1B22_00345	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E1B22_00355	COG0277	FAD linked oxidase domain protein
E1B22_00355	COG0247	lactate metabolic process
E1B22_00360	COG2318	DinB family
E1B22_00375	COG0077	Prephenate dehydratase
E1B22_00405	COG2224	Isocitrate lyase
E1B22_00410	COG0440	acetolactate synthase activity
E1B22_00420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E1B22_00425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E1B22_00430	COG0066	3-isopropylmalate dehydratase activity
E1B22_00435	COG0473	3-isopropylmalate dehydrogenase activity
E1B22_00445	COG0028	Belongs to the TPP enzyme family
E1B22_00455	COG0523	cobalamin synthesis protein
E1B22_00505	COG2390	Transcriptional regulator
E1B22_00510	COG0508	dehydrogenase complex catalyzes the overall conversion of
E1B22_00515	COG0508	dehydrogenase complex catalyzes the overall conversion of
E1B22_00515	COG0022	dehydrogenase e1 component
E1B22_00520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E1B22_00530	COG3730	PTS system glucitol sorbitol-specific
E1B22_00535	COG3732	PTS system glucitol sorbitol-specific
E1B22_00550	COG3775	system Galactitol-specific IIC component
E1B22_00555	COG3414	Phosphotransferase system galactitol-specific IIB component
E1B22_00560	COG1012	belongs to the aldehyde dehydrogenase family
E1B22_00580	COG2030	dehydratase
E1B22_00585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E1B22_00590	COG1757	Na H antiporter
E1B22_00595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E1B22_00615	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E1B22_00630	COG1960	acyl-CoA dehydrogenase activity
E1B22_00640	COG1846	Transcriptional regulator
E1B22_00665	COG1012	belongs to the aldehyde dehydrogenase family
E1B22_00685	COG0697	spore germination
E1B22_00730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E1B22_00745	COG0697	spore germination
E1B22_00750	COG2031	fatty acid transporter
E1B22_00770	COG0352	thiamine-phosphate diphosphorylase activity
E1B22_00775	COG2022	thiamine diphosphate biosynthetic process
E1B22_00780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E1B22_00785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E1B22_00790	COG0693	protein deglycase activity
E1B22_00795	COG4336	lyase activity
E1B22_00800	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E1B22_00805	COG1984	allophanate hydrolase subunit 2
E1B22_00810	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E1B22_00835	COG0318	PFAM AMP-dependent synthetase and ligase
E1B22_00840	COG1960	acyl-CoA dehydrogenase activity
E1B22_00865	COG4584	PFAM Integrase catalytic
E1B22_00870	COG1484	DNA-dependent DNA replication
E1B22_00910	COG3033	Beta-eliminating lyase
E1B22_00925	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
E1B22_00930	COG0252	asparaginase activity
E1B22_00940	COG0523	cobalamin synthesis protein
E1B22_00990	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E1B22_01015	COG0066	3-isopropylmalate dehydratase activity
E1B22_01020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E1B22_01030	COG1802	Transcriptional regulator
E1B22_01070	COG4412	M6 family metalloprotease domain protein
E1B22_01070	COG1404	Belongs to the peptidase S8 family
E1B22_01085	COG1131	(ABC) transporter
E1B22_01095	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E1B22_01115	COG2084	Dehydrogenase
E1B22_01135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E1B22_01180	COG1131	(ABC) transporter
E1B22_01190	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E1B22_01215	COG1205	dead DEAH box helicase
E1B22_01215	COG1111	helicase
E1B22_01240	COG1331	Highly conserved protein containing a thioredoxin domain
E1B22_01245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E1B22_01270	COG1070	Carbohydrate kinase
E1B22_01280	COG1940	carbohydrate kinase activity
E1B22_01295	COG3959	Transketolase, thiamine diphosphate binding domain
E1B22_01300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E1B22_01310	COG0803	Belongs to the bacterial solute-binding protein 9 family
E1B22_01315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E1B22_01320	COG1121	(ABC) transporter
E1B22_01330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E1B22_01360	COG0352	thiamine-phosphate diphosphorylase activity
E1B22_01360	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E1B22_01365	COG2814	Major facilitator Superfamily
E1B22_01375	COG3842	ATPase activity
E1B22_01400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E1B22_01405	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E1B22_01415	COG3395	kinase activity
E1B22_01420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E1B22_01450	COG2079	MmgE PrpD family protein
E1B22_01455	COG0372	Belongs to the citrate synthase family
E1B22_01480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E1B22_01480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E1B22_01485	COG0584	glycerophosphoryl diester phosphodiesterase
E1B22_01495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E1B22_01505	COG0604	alcohol dehydrogenase
E1B22_01515	COG0366	Alpha amylase catalytic
E1B22_01520	COG0395	ABC-type sugar transport system, permease component
E1B22_01535	COG3842	ATPase activity
E1B22_01540	COG0861	Integral membrane protein TerC family
E1B22_01545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E1B22_01545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E1B22_01550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E1B22_01550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E1B22_01555	COG0859	PFAM glycosyl transferase family 9
E1B22_01565	COG1349	DNA-binding transcription factor activity
E1B22_01570	COG3395	kinase activity
E1B22_01575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E1B22_01580	COG2610	gluconate transmembrane transporter activity
E1B22_01600	COG0822	iron-sulfur transferase activity
E1B22_01605	COG2897	thiosulfate sulfurtransferase activity
E1B22_01620	COG3949	Membrane
E1B22_01625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E1B22_01630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E1B22_01650	COG1278	Cold shock
E1B22_01655	COG1252	NADH dehydrogenase
E1B22_01675	COG2814	Major facilitator Superfamily
E1B22_01685	COG0012	GTP binding
E1B22_01715	COG0640	Transcriptional regulator
E1B22_01720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E1B22_01730	COG0719	Fe-S assembly protein
E1B22_01740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E1B22_01745	COG0284	orotidine-5'-phosphate decarboxylase activity
E1B22_01750	COG0167	dihydroorotate dehydrogenase activity
E1B22_01765	COG0505	Belongs to the CarA family
E1B22_01780	COG2217	Heavy metal translocating P-type atpase
E1B22_01785	COG2217	Heavy metal translocating P-type atpase
E1B22_01790	COG0640	Transcriptional regulator
E1B22_01815	COG1752	Esterase of the alpha-beta hydrolase superfamily
E1B22_01835	COG0785	Cytochrome C biogenesis protein
E1B22_01890	COG3291	Pkd domain containing protein
E1B22_01890	COG4412	M6 family metalloprotease domain protein
E1B22_01910	COG0328	RNA-DNA hybrid ribonuclease activity
E1B22_01910	COG0406	alpha-ribazole phosphatase activity
E1B22_01915	COG2384	SAM-dependent methyltransferase
E1B22_01925	COG0037	tRNA processing
E1B22_01940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E1B22_01945	COG2045	Belongs to the ComB family
E1B22_01950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E1B22_01955	COG1138	Cytochrome C-type biogenesis protein
E1B22_01960	COG3088	subunit of a heme lyase
E1B22_01965	COG4347	Protein of unknown function (DUF1405)
E1B22_01970	COG3409	Peptidoglycan-binding domain 1 protein
E1B22_01970	COG3773	Cell wall hydrolase
E1B22_01975	COG1078	dGTPase activity
E1B22_01980	COG0314	molybdopterin synthase activity
E1B22_01995	COG3639	organic phosphonate transmembrane transporter activity
E1B22_02010	COG0725	ABC transporter, periplasmic molybdate-binding protein
E1B22_02015	COG4149	molybdate abc transporter
E1B22_02030	COG3547	Transposase (IS116 IS110 IS902 family)
E1B22_02065	COG3547	Transposase (IS116 IS110 IS902 family)
E1B22_02070	COG2801	Transposase and inactivated derivatives
E1B22_02085	COG2217	Heavy metal translocating P-type atpase
E1B22_02090	COG0640	Transcriptional regulator
E1B22_02095	COG2801	Transposase and inactivated derivatives
E1B22_02145	COG0277	FAD linked oxidase domain protein
E1B22_02160	COG2201	protein-glutamate methylesterase activity
E1B22_02170	COG0835	chemotaxis
E1B22_02175	COG0643	Histidine kinase
E1B22_02175	COG2198	Histidine kinase
E1B22_02180	COG2201	protein-glutamate methylesterase activity
E1B22_02185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E1B22_02205	COG1363	Peptidase, m42
E1B22_02220	COG2226	methyltransferase
E1B22_02260	COG0860	N-Acetylmuramoyl-L-alanine amidase
E1B22_02285	COG2197	response regulator
E1B22_02290	COG4585	Histidine kinase
E1B22_02300	COG0842	Transport permease protein
E1B22_02300	COG1511	domain protein
E1B22_02305	COG1131	(ABC) transporter
E1B22_02320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E1B22_02335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E1B22_02340	COG0358	DNA primase activity
E1B22_02345	COG0183	Belongs to the thiolase family
E1B22_02350	COG1250	3-hydroxyacyl-CoA dehydrogenase
E1B22_02355	COG1024	Enoyl-CoA hydratase
E1B22_02360	COG2151	metal-sulfur cluster biosynthetic enzyme
E1B22_02375	COG3396	Phenylacetate-CoA oxygenase
E1B22_02405	COG3279	Response regulator of the LytR AlgR family
E1B22_02420	COG0598	Magnesium transport protein CorA
E1B22_02445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E1B22_02450	COG2076	Multidrug Resistance protein
E1B22_02455	COG0475	glutathione-regulated potassium exporter activity
E1B22_02460	COG0490	domain, Protein
E1B22_02465	COG0574	Belongs to the PEP-utilizing enzyme family
E1B22_02465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E1B22_02470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E1B22_02495	COG0751	glycine-tRNA ligase activity
E1B22_02500	COG0752	glycyl-tRNA synthetase alpha subunit
E1B22_02510	COG1381	Involved in DNA repair and RecF pathway recombination
E1B22_02520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E1B22_02525	COG1470	cell adhesion involved in biofilm formation
E1B22_02535	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E1B22_02565	COG4864	UPF0365 protein
E1B22_02570	COG1030	water channel activity
E1B22_02580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E1B22_02585	COG0537	adenosine 5'-monophosphoramidase activity
E1B22_02590	COG1181	Belongs to the D-alanine--D-alanine ligase family
E1B22_02595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E1B22_02600	COG2264	protein methyltransferase activity
E1B22_02615	COG0443	Heat shock 70 kDa protein
E1B22_02620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E1B22_02625	COG1420	regulation of RNA biosynthetic process
E1B22_02630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E1B22_02635	COG0481	GTPase activity
E1B22_02655	COG0268	Binds directly to 16S ribosomal RNA
E1B22_02680	COG0495	leucyl-tRNA aminoacylation
E1B22_02690	COG0799	negative regulation of ribosome biogenesis
E1B22_02695	COG1316	TRANSCRIPTIONal
E1B22_02700	COG1713	HD superfamily hydrolase involved in NAD metabolism
E1B22_02705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E1B22_02710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E1B22_02720	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E1B22_02725	COG2868	ribosomal protein
E1B22_02730	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E1B22_02735	COG1530	ribonuclease E activity
E1B22_02745	COG4942	peptidase
E1B22_02745	COG1388	LysM domain
E1B22_02750	COG0772	Belongs to the SEDS family
E1B22_02755	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E1B22_02760	COG2894	cell division
E1B22_02765	COG0850	regulation of cytokinetic process
E1B22_02780	COG1792	Involved in formation and maintenance of cell shape
E1B22_02785	COG1077	Cell shape determining protein MreB Mrl
E1B22_02790	COG2003	Belongs to the UPF0758 family
E1B22_02795	COG0424	maF-like protein
E1B22_02805	COG0525	valine-tRNA ligase activity
E1B22_02815	COG4152	abc transporter atp-binding protein
E1B22_02825	COG1067	ATP-dependent peptidase activity
E1B22_02825	COG0470	DNA polymerase III
E1B22_02830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E1B22_02835	COG0740	serine-type endopeptidase activity
E1B22_02840	COG0544	peptidyl-prolyl cis-trans isomerase activity
E1B22_02855	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E1B22_02905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E1B22_02915	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
E1B22_02920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E1B22_02930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E1B22_02935	COG0557	exoribonuclease II activity
E1B22_02940	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E1B22_02945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E1B22_02950	COG0148	phosphopyruvate hydratase activity
E1B22_02955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E1B22_02960	COG0149	triose-phosphate isomerase activity
E1B22_02965	COG0126	phosphoglycerate kinase activity
E1B22_02980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E1B22_02995	COG1012	belongs to the aldehyde dehydrogenase family
E1B22_03000	COG0735	belongs to the Fur family
E1B22_03035	COG0003	Pfam Anion-transporting ATPase
E1B22_03040	COG0003	Pfam Anion-transporting ATPase
E1B22_03050	COG1966	Carbon starvation protein
E1B22_03060	COG0439	Biotin carboxylase
E1B22_03065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E1B22_03070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E1B22_03075	COG0101	tRNA pseudouridine synthase activity
E1B22_03080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E1B22_03085	COG1122	ATPase activity
E1B22_03090	COG1122	ATPase activity
E1B22_03095	COG0203	ribosomal protein L17
E1B22_03100	COG0202	RNA polymerase activity
E1B22_03105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E1B22_03110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E1B22_03115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E1B22_03120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E1B22_03130	COG0024	Methionine aminopeptidase
E1B22_03140	COG0201	protein transport
E1B22_03145	COG0200	Binds to the 23S rRNA
E1B22_03150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E1B22_03155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E1B22_03160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E1B22_03165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E1B22_03170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E1B22_03175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E1B22_03180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E1B22_03185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E1B22_03190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E1B22_03195	COG0255	Belongs to the universal ribosomal protein uL29 family
E1B22_03200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E1B22_03205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E1B22_03210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E1B22_03215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E1B22_03220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E1B22_03225	COG0089	rRNA binding
E1B22_03230	COG0088	Forms part of the polypeptide exit tunnel
E1B22_03235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E1B22_03240	COG0051	transcription antitermination factor activity, RNA binding
E1B22_03245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E1B22_03250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E1B22_03255	COG0049	tRNA binding
E1B22_03260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E1B22_03265	COG1358	cellular component organization or biogenesis
E1B22_03270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E1B22_03275	COG0085	RNA polymerase activity
E1B22_03280	COG0222	ribosome binding
E1B22_03285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E1B22_03290	COG0081	regulation of translation
E1B22_03295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E1B22_03300	COG0250	Participates in transcription elongation, termination and antitermination
E1B22_03305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E1B22_03315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E1B22_03320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E1B22_03350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E1B22_03355	COG0215	cysteine-tRNA ligase activity
E1B22_03365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E1B22_03370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E1B22_03370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E1B22_03375	COG4956	integral membrane protein (PIN domain superfamily)
E1B22_03380	COG1329	Transcriptional regulator
E1B22_03390	COG0175	sulfate reduction
E1B22_03395	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
E1B22_03400	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E1B22_03405	COG0542	response to heat
E1B22_03410	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E1B22_03415	COG3880	PFAM UvrB UvrC protein
E1B22_03425	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E1B22_03430	COG1324	tolerance protein
E1B22_03435	COG1522	sequence-specific DNA binding
E1B22_03440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E1B22_03445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E1B22_03465	COG0616	signal peptide processing
E1B22_03470	COG0504	CTP synthase activity
E1B22_03475	COG0018	arginyl-trna synthetase
E1B22_03480	COG0010	Belongs to the arginase family
E1B22_03485	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E1B22_03500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E1B22_03510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E1B22_03520	COG1196	nuclear chromosome segregation
E1B22_03520	COG0741	lytic transglycosylase activity
E1B22_03520	COG0739	heme binding
E1B22_03540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E1B22_03545	COG0305	Participates in initiation and elongation during chromosome replication
E1B22_03550	COG0359	binds to the 23S rRNA
E1B22_03560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E1B22_03565	COG0629	single-stranded DNA binding
E1B22_03570	COG0360	Binds together with S18 to 16S ribosomal RNA
E1B22_03575	COG4481	Protein conserved in bacteria
E1B22_03590	COG0411	ABC transporter
E1B22_03600	COG0559	Belongs to the binding-protein-dependent transport system permease family
E1B22_03625	COG1475	DNA binding
E1B22_03630	COG1192	Involved in chromosome partitioning
E1B22_03640	COG0357	Ribosomal RNA small subunit methyltransferase G
E1B22_03650	COG0706	membrane insertase activity
E1B22_03655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E1B22_03660	COG0594	ribonuclease P activity
E1B22_03665	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E1B22_03670	COG3464	Transposase
E1B22_03675	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E1B22_03680	COG0592	DNA-directed DNA polymerase activity
E1B22_03685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E1B22_03700	COG0187	DNA topoisomerase II activity
E1B22_03705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E1B22_03710	COG0709	Synthesizes selenophosphate from selenide and ATP
E1B22_03715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E1B22_03740	COG0582	viral genome integration into host DNA
E1B22_03795	COG0740	serine-type endopeptidase activity
E1B22_03805	COG4708	membrane
E1B22_03840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E1B22_03845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E1B22_03850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E1B22_03865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E1B22_03900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E1B22_03905	COG3870	Protein conserved in bacteria
E1B22_03910	COG0470	DNA polymerase III
E1B22_03920	COG2002	toxin-antitoxin pair type II binding
E1B22_03930	COG3464	Transposase
E1B22_03940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E1B22_03940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E1B22_03945	COG0084	hydrolase, TatD family'
E1B22_03950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E1B22_03955	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
E1B22_03965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E1B22_03975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E1B22_03980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E1B22_03985	COG2088	sporulation resulting in formation of a cellular spore
E1B22_04000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E1B22_04005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E1B22_04010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E1B22_04015	COG0193	aminoacyl-tRNA hydrolase activity
E1B22_04025	COG2002	toxin-antitoxin pair type II binding
E1B22_04030	COG3956	TIGRFAM MazG family protein
E1B22_04075	COG0492	ferredoxin-NADP+ reductase activity
E1B22_04090	COG0822	iron-sulfur transferase activity
E1B22_04095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E1B22_04100	COG0719	Fe-S assembly protein
E1B22_04105	COG0396	ATPase activity
E1B22_04115	COG1363	Peptidase, m42
E1B22_04120	COG2009	succinate dehydrogenase
E1B22_04135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E1B22_04145	COG2096	Adenosyltransferase
E1B22_04175	COG1260	myo-inositol-1-phosphate synthase
E1B22_04180	COG1213	nucleotidyl transferase
E1B22_04180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E1B22_04185	COG2135	peptidase activity
E1B22_04215	COG0037	tRNA processing
E1B22_04220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E1B22_04225	COG0617	tRNA 3'-terminal CCA addition
E1B22_04235	COG2986	histidine ammonia-lyase
E1B22_04240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E1B22_04245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E1B22_04250	COG3191	aminopeptidase activity
E1B22_04275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E1B22_04320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E1B22_04325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E1B22_04330	COG0739	heme binding
E1B22_04335	COG0254	rRNA binding
E1B22_04340	COG3872	metal-dependent enzyme
E1B22_04345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E1B22_04350	COG2890	protein-(glutamine-N5) methyltransferase activity
E1B22_04355	COG0009	L-threonylcarbamoyladenylate synthase
E1B22_04360	COG0698	ribose 5-phosphate isomerase
E1B22_04365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E1B22_04370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E1B22_04385	COG0356	it plays a direct role in the translocation of protons across the membrane
E1B22_04390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E1B22_04405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E1B22_04410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E1B22_04415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E1B22_04420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E1B22_04425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E1B22_04430	COG2385	sporulation resulting in formation of a cellular spore
E1B22_04435	COG0739	heme binding
E1B22_04440	COG1609	Transcriptional regulator
E1B22_04445	COG1077	Cell shape determining protein MreB Mrl
E1B22_04465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E1B22_04470	COG1185	polyribonucleotide nucleotidyltransferase activity
E1B22_04475	COG0561	phosphatase activity
E1B22_04490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E1B22_04505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E1B22_04515	COG3706	GGDEF domain
E1B22_04520	COG1040	competence protein
E1B22_04545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E1B22_04550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E1B22_04585	COG0653	protein targeting
E1B22_04595	COG2884	Cell division ATP-binding protein ftsE
E1B22_04600	COG2177	Part of the ABC transporter FtsEX involved in
E1B22_04610	COG0793	Belongs to the peptidase S41A family
E1B22_04620	COG0556	nucleotide-excision repair
E1B22_04625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E1B22_04655	COG0322	excinuclease ABC activity
E1B22_04665	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E1B22_04675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E1B22_04680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E1B22_04690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E1B22_04695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E1B22_04700	COG0287	Prephenate dehydrogenase
E1B22_04725	COG2239	Acts as a magnesium transporter
E1B22_04740	COG1660	Displays ATPase and GTPase activities
E1B22_04745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E1B22_04750	COG1481	regulation of sporulation
E1B22_04760	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E1B22_04765	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E1B22_04775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E1B22_04780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E1B22_04790	COG1131	(ABC) transporter
E1B22_04800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E1B22_04805	COG2309	aminopeptidase activity
E1B22_04810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E1B22_04825	COG0446	pyridine nucleotide-disulphide oxidoreductase
E1B22_04835	COG0640	Transcriptional regulator
E1B22_04840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E1B22_04855	COG0425	Belongs to the sulfur carrier protein TusA family
E1B22_04855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E1B22_04860	COG2210	Belongs to the sulfur carrier protein TusA family
E1B22_04865	COG0730	response to heat
E1B22_04890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E1B22_04895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E1B22_04900	COG0736	holo-[acyl-carrier-protein] synthase activity
E1B22_04905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E1B22_04905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E1B22_04910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E1B22_04920	COG2337	Toxic component of a toxin-antitoxin (TA) module
E1B22_04935	COG0802	atpase or kinase
E1B22_04940	COG1214	PFAM Peptidase M22, glycoprotease
E1B22_04945	COG0456	acetyltransferase
E1B22_04950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E1B22_04955	COG0110	maltose O-acetyltransferase activity
E1B22_04960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E1B22_04965	COG0516	GMP reductase activity
E1B22_04965	COG0517	IMP dehydrogenase activity
E1B22_04970	COG0285	dihydrofolate synthase activity
E1B22_04975	COG0183	Belongs to the thiolase family
E1B22_04980	COG0303	'Molybdopterin
E1B22_04985	COG0315	cyclic pyranopterin monophosphate synthase activity
E1B22_04990	COG0521	Mo-molybdopterin cofactor biosynthetic process
E1B22_04990	COG0315	cyclic pyranopterin monophosphate synthase activity
E1B22_04995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E1B22_05000	COG0459	protein refolding
E1B22_05005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E1B22_05005	COG0519	Catalyzes the synthesis of GMP from XMP
E1B22_05010	COG5002	protein histidine kinase activity
E1B22_05025	COG0444	Belongs to the ABC transporter superfamily
E1B22_05030	COG4608	Belongs to the ABC transporter superfamily
E1B22_05035	COG4166	transmembrane transport
E1B22_05040	COG0601	transmembrane transport
E1B22_05045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E1B22_05050	COG0444	Belongs to the ABC transporter superfamily
E1B22_05055	COG4608	Belongs to the ABC transporter superfamily
E1B22_05080	COG0385	Bile acid
E1B22_05085	COG0006	proline dipeptidase activity
E1B22_05090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E1B22_05095	COG0154	amidase activity
E1B22_05100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E1B22_05105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E1B22_05110	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
E1B22_05135	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E1B22_05140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E1B22_05145	COG0649	NAD binding
E1B22_05150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E1B22_05155	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E1B22_05170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E1B22_05180	COG1007	ATP synthesis coupled electron transport
E1B22_05185	COG0589	response to stress
E1B22_05190	COG0475	glutathione-regulated potassium exporter activity
E1B22_05200	COG2010	Cytochrome c
E1B22_05230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E1B22_05235	COG1372	Participates in initiation and elongation during chromosome replication
E1B22_05235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E1B22_05240	COG0840	transmembrane signaling receptor activity
E1B22_05245	COG1028	Short-chain dehydrogenase reductase Sdr
E1B22_05250	COG0697	spore germination
E1B22_05280	COG3464	Transposase
E1B22_05285	COG1305	Transglutaminase-like
E1B22_05300	COG0714	Associated with various cellular activities
E1B22_05305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E1B22_05310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E1B22_05320	COG4086	secreted protein
E1B22_05325	COG0586	Pfam SNARE associated Golgi protein
E1B22_05335	COG2385	sporulation resulting in formation of a cellular spore
E1B22_05350	COG1234	tRNA 3'-trailer cleavage
E1B22_05360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E1B22_05375	COG1609	Transcriptional regulator
E1B22_05380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E1B22_05385	COG1869	D-ribose catabolic process
E1B22_05390	COG1129	ABC transporter
E1B22_05395	COG1172	Belongs to the binding-protein-dependent transport system permease family
E1B22_05400	COG1879	ABC-type sugar transport system periplasmic component
E1B22_05410	COG0497	DNA recombination
E1B22_05440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E1B22_05455	COG0730	response to heat
E1B22_05475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E1B22_05485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E1B22_05490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E1B22_05495	COG2718	Belongs to the UPF0229 family
E1B22_05500	COG2719	SpoVR family
E1B22_05505	COG2766	serine protein kinase
E1B22_05520	COG0205	6-phosphofructokinase activity
E1B22_05530	COG0489	protein tyrosine kinase activity
E1B22_05530	COG2151	metal-sulfur cluster biosynthetic enzyme
E1B22_05570	COG2514	catechol 2,3-dioxygenase activity
E1B22_05585	COG0653	protein targeting
E1B22_05605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E1B22_05610	COG1447	Phosphotransferase system cellobiose-specific component IIA
E1B22_05620	COG0183	Belongs to the thiolase family
E1B22_05630	COG0318	PFAM AMP-dependent synthetase and ligase
E1B22_05650	COG1063	alcohol dehydrogenase
E1B22_05655	COG0662	Cupin 2, conserved barrel domain protein
E1B22_05670	COG1612	heme a metabolic process
E1B22_05675	COG0109	protoheme IX farnesyltransferase activity
E1B22_05680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E1B22_05685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E1B22_05695	COG1845	cytochrome c oxidase, subunit III
E1B22_05710	COG2340	Cysteine-rich secretory protein family
E1B22_05720	COG0739	heme binding
E1B22_05780	COG3773	Cell wall hydrolase
E1B22_05780	COG3409	Peptidoglycan-binding domain 1 protein
E1B22_05785	COG3409	Peptidoglycan-binding domain 1 protein
E1B22_05785	COG3773	Cell wall hydrolase
E1B22_05795	COG0237	dephospho-CoA kinase activity
E1B22_05815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E1B22_05820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E1B22_05825	COG1028	Short-chain dehydrogenase reductase Sdr
E1B22_05835	COG0860	N-Acetylmuramoyl-L-alanine amidase
E1B22_05850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E1B22_05855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E1B22_05860	COG2222	sugar isomerase
E1B22_05895	COG0346	lactoylglutathione lyase activity
E1B22_05905	COG0789	Transcriptional regulator
E1B22_05910	COG0174	glutamine synthetase
E1B22_05935	COG1132	(ABC) transporter
E1B22_05960	COG1494	fructose-1,6-bisphosphatase
E1B22_05970	COG0693	protein deglycase activity
E1B22_05980	COG4948	Mandelate Racemase Muconate Lactonizing
E1B22_05990	COG0726	polysaccharide deacetylase
E1B22_06020	COG2086	electron transfer activity
E1B22_06025	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E1B22_06030	COG0247	lactate metabolic process
E1B22_06030	COG2181	nitrate reductase activity
E1B22_06035	COG0318	PFAM AMP-dependent synthetase and ligase
E1B22_06060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E1B22_06070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E1B22_06095	COG0154	amidase activity
E1B22_06125	COG1178	ABC-type Fe3 transport system permease component
E1B22_06140	COG1196	nuclear chromosome segregation
E1B22_06150	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E1B22_06165	COG0477	Major facilitator Superfamily
E1B22_06180	COG1940	carbohydrate kinase activity
E1B22_06190	COG1595	DNA-templated transcription, initiation
E1B22_06200	COG4133	protoheme IX ABC transporter activity
E1B22_06210	COG1131	(ABC) transporter
E1B22_06240	COG1024	Enoyl-CoA hydratase
E1B22_06245	COG2348	transferase activity, transferring amino-acyl groups
E1B22_06250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E1B22_06260	COG0011	TIGRFAM Protein of
E1B22_06265	COG0477	Major facilitator Superfamily
E1B22_06275	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E1B22_06280	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E1B22_06285	COG1268	BioY protein
E1B22_06290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E1B22_06295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E1B22_06310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E1B22_06325	COG0165	Argininosuccinate lyase
E1B22_06380	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E1B22_06385	COG4176	ABC-type proline glycine betaine transport system permease component
E1B22_06420	COG3546	catalase activity
E1B22_06430	COG0735	belongs to the Fur family
E1B22_06435	COG1121	(ABC) transporter
E1B22_06440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E1B22_06445	COG0803	Belongs to the bacterial solute-binding protein 9 family
E1B22_06450	COG2223	nitrite transmembrane transporter activity
E1B22_06455	COG1999	signal sequence binding
E1B22_06500	COG0823	Involved in the tonB-independent uptake of proteins
E1B22_06500	COG1506	peptidase
E1B22_06500	COG4946	Tricorn protease homolog
E1B22_06510	COG0739	heme binding
E1B22_06510	COG1196	nuclear chromosome segregation
E1B22_06510	COG0741	lytic transglycosylase activity
E1B22_06520	COG2011	ABC-type metal ion transport system permease component
E1B22_06530	COG0367	asparagine synthase
E1B22_06540	COG0411	ABC transporter
E1B22_06555	COG0697	spore germination
E1B22_06565	COG1472	Belongs to the glycosyl hydrolase 3 family
E1B22_06570	COG3876	Protein conserved in bacteria
E1B22_06580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E1B22_06580	COG1263	PTS System
E1B22_06585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E1B22_06595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E1B22_06605	COG0561	phosphatase activity
E1B22_06610	COG0506	proline dehydrogenase activity
E1B22_06615	COG0140	phosphoribosyl-ATP diphosphatase activity
E1B22_06615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E1B22_06620	COG0107	imidazoleglycerol-phosphate synthase activity
E1B22_06625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E1B22_06635	COG0131	Imidazoleglycerol-phosphate dehydratase
E1B22_06640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E1B22_06640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E1B22_06645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E1B22_06655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E1B22_06665	COG2423	ornithine cyclodeaminase activity
E1B22_06700	COG1388	LysM domain
E1B22_06715	COG0745	RESPONSE REGULATOR receiver
E1B22_06750	COG1063	alcohol dehydrogenase
E1B22_06755	COG3464	Transposase
E1B22_06765	COG0235	Class ii aldolase
E1B22_06775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E1B22_06775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E1B22_06780	COG0668	transmembrane transport
E1B22_06785	COG0768	penicillin binding
E1B22_06815	COG0004	ammonium transporteR
E1B22_06820	COG0367	asparagine synthase
E1B22_06870	COG0438	transferase activity, transferring glycosyl groups
E1B22_06875	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E1B22_06890	COG2247	cell wall binding repeat
E1B22_06890	COG2385	sporulation resulting in formation of a cellular spore
E1B22_06930	COG0463	Glycosyl transferase, family 2
E1B22_06935	COG0438	transferase activity, transferring glycosyl groups
E1B22_06950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E1B22_06960	COG0728	peptidoglycan biosynthetic process
E1B22_06980	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E1B22_06990	COG1228	amidohydrolase
E1B22_06995	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
E1B22_07005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E1B22_07010	COG2318	DinB family
E1B22_07030	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E1B22_07045	COG4969	Belongs to the N-Me-Phe pilin family
E1B22_07100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E1B22_07110	COG0728	peptidoglycan biosynthetic process
E1B22_07115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E1B22_07140	COG0438	transferase activity, transferring glycosyl groups
E1B22_07150	COG0390	transport system, permease component
E1B22_07155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E1B22_07175	COG3944	biosynthesis protein
E1B22_07180	COG0489	protein tyrosine kinase activity
E1B22_07185	COG0463	Glycosyl transferase, family 2
E1B22_07190	COG0463	Glycosyl transferase, family 2
E1B22_07215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E1B22_07220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E1B22_07240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E1B22_07250	COG4294	response to UV
E1B22_07265	COG1960	acyl-CoA dehydrogenase activity
E1B22_07290	COG1316	TRANSCRIPTIONal
E1B22_07295	COG3706	GGDEF domain
E1B22_07295	COG0745	RESPONSE REGULATOR receiver
E1B22_07305	COG1028	Short-chain dehydrogenase reductase Sdr
E1B22_07315	COG1115	amino acid carrier protein
E1B22_07325	COG0601	transmembrane transport
E1B22_07335	COG3949	Membrane
E1B22_07340	COG1473	amidohydrolase
E1B22_07355	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E1B22_07360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E1B22_07365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E1B22_07375	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E1B22_07385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E1B22_07395	COG4176	ABC-type proline glycine betaine transport system permease component
E1B22_07415	COG2133	pyrroloquinoline quinone binding
E1B22_07425	COG0745	RESPONSE REGULATOR receiver
E1B22_07430	COG3850	Histidine kinase
E1B22_07430	COG5002	protein histidine kinase activity
E1B22_07435	COG0701	Predicted permease
E1B22_07440	COG0069	glutamate synthase activity
E1B22_07480	COG0483	inositol monophosphate 1-phosphatase activity
E1B22_07490	COG1253	flavin adenine dinucleotide binding
E1B22_07495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E1B22_07505	COG4717	serine-type aminopeptidase activity
E1B22_07510	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E1B22_07530	COG1028	Short-chain dehydrogenase reductase Sdr
E1B22_07535	COG0492	ferredoxin-NADP+ reductase activity
E1B22_07550	COG2252	PERMEase
E1B22_07575	COG2197	response regulator
E1B22_07650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E1B22_07675	COG1254	Belongs to the acylphosphatase family
E1B22_07680	COG0730	response to heat
E1B22_07690	COG2707	UPF0756 membrane protein
E1B22_07700	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E1B22_07725	COG1164	Oligoendopeptidase f
E1B22_07730	COG3464	Transposase
E1B22_07750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E1B22_07770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E1B22_07775	COG0747	negative chemotaxis
E1B22_07790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E1B22_07795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E1B22_07805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E1B22_07810	COG0569	domain protein
E1B22_07815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E1B22_07825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E1B22_07830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E1B22_07830	COG0072	phenylalanine-tRNA ligase activity
E1B22_07840	COG1796	DNA polymerase
E1B22_07840	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E1B22_07845	COG1193	negative regulation of DNA recombination
E1B22_07855	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E1B22_07865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E1B22_07870	COG0217	transcriptional regulatory protein
E1B22_07880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E1B22_07885	COG0632	four-way junction helicase activity
E1B22_07890	COG2255	four-way junction helicase activity
E1B22_07900	COG1191	sigma factor activity
E1B22_07910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E1B22_07915	COG0343	queuine tRNA-ribosyltransferase activity
E1B22_07920	COG1862	Preprotein translocase
E1B22_07925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E1B22_07930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E1B22_07940	COG4770	biotin carboxylase activity
E1B22_07945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E1B22_07955	COG2001	Belongs to the MraZ family
E1B22_07960	COG0275	rRNA processing
E1B22_07975	COG0768	penicillin binding
E1B22_07990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E1B22_07995	COG0772	Belongs to the SEDS family
E1B22_08005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E1B22_08015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E1B22_08030	COG1191	sigma factor activity
E1B22_08040	COG1191	sigma factor activity
E1B22_08050	COG1873	PFAM PRC-barrel domain
E1B22_08060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E1B22_08065	COG1799	cell septum assembly
E1B22_08070	COG0762	integral membrane protein
E1B22_08075	COG3599	regulation of cell shape
E1B22_08080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E1B22_08090	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E1B22_08095	COG1980	fructose-bisphosphate aldolase activity
E1B22_08105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E1B22_08110	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E1B22_08115	COG0564	pseudouridine synthase activity
E1B22_08120	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E1B22_08125	COG1929	Belongs to the glycerate kinase type-1 family
E1B22_08140	COG0395	ABC-type sugar transport system, permease component
E1B22_08160	COG1024	Enoyl-CoA hydratase
E1B22_08160	COG1250	3-hydroxyacyl-CoA dehydrogenase
E1B22_08165	COG0183	Belongs to the thiolase family
E1B22_08170	COG1960	acyl-CoA dehydrogenase activity
E1B22_08175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E1B22_08210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E1B22_08220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E1B22_08225	COG0436	Aminotransferase
E1B22_08235	COG1561	YicC-like family, N-terminal region
E1B22_08240	COG2052	Domain of unknown function (DUF370)
E1B22_08245	COG0194	GDP metabolic process
E1B22_08250	COG1758	RNA polymerase activity
E1B22_08255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E1B22_08260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E1B22_08265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E1B22_08270	COG2738	Putative neutral zinc metallopeptidase
E1B22_08280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E1B22_08285	COG0631	protein serine/threonine phosphatase activity
E1B22_08290	COG2815	serine threonine protein kinase
E1B22_08290	COG0515	serine threonine protein kinase
E1B22_08300	COG1162	GTPase activity
E1B22_08310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E1B22_08315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E1B22_08325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E1B22_08335	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E1B22_08340	COG2814	Major facilitator Superfamily
E1B22_08350	COG0742	ribosomal rna small subunit methyltransferase
E1B22_08355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E1B22_08365	COG3314	Sporulation integral membrane protein YlbJ
E1B22_08380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E1B22_08390	COG0416	fatty acid biosynthetic process
E1B22_08400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E1B22_08405	COG1028	Short-chain dehydrogenase reductase Sdr
E1B22_08410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E1B22_08415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E1B22_08420	COG0571	ribonuclease III activity
E1B22_08430	COG2359	stage V sporulation protein S
E1B22_08435	COG1196	nuclear chromosome segregation
E1B22_08440	COG0552	protein localization to endoplasmic reticulum
E1B22_08445	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
E1B22_08450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E1B22_08455	COG0228	four-way junction DNA binding
E1B22_08460	COG1837	Belongs to the UPF0109 family
E1B22_08465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E1B22_08470	COG0336	Belongs to the RNA methyltransferase TrmD family
E1B22_08475	COG0335	large ribosomal subunit rRNA binding
E1B22_08480	COG0681	Belongs to the peptidase S26 family
E1B22_08485	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E1B22_08495	COG0792	nuclease activity
E1B22_08500	COG0606	chelatase, subunit chli
E1B22_08505	COG4166	transmembrane transport
E1B22_08510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E1B22_08510	COG0758	DNA mediated transformation
E1B22_08515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E1B22_08530	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E1B22_08535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E1B22_08540	COG1815	bacterial-type flagellum-dependent cell motility
E1B22_08560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E1B22_08590	COG4786	Flagellar basal body rod
E1B22_08605	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E1B22_08610	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E1B22_08610	COG1776	CheC inhibitor of MCP methylation
E1B22_08625	COG1338	Plays a role in the flagellum-specific transport system
E1B22_08630	COG1987	bacterial-type flagellum assembly
E1B22_08635	COG1684	flagellar biosynthetic protein fliR
E1B22_08640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E1B22_08645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E1B22_08650	COG1419	protein localization to endoplasmic reticulum
E1B22_08655	COG0455	bacterial-type flagellum organization
E1B22_08665	COG1191	sigma factor activity
E1B22_08680	COG3464	Transposase
E1B22_08685	COG0052	Belongs to the universal ribosomal protein uS2 family
E1B22_08690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E1B22_08695	COG0528	UMP kinase activity
E1B22_08700	COG0233	cytoplasmic translational termination
E1B22_08715	COG0575	Belongs to the CDS family
E1B22_08720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E1B22_08725	COG0750	zinc metalloprotease
E1B22_08730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E1B22_08735	COG0442	prolyl-tRNA aminoacylation
E1B22_08745	COG0779	Required for maturation of 30S ribosomal subunits
E1B22_08750	COG0195	Participates in both transcription termination and antitermination
E1B22_08755	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E1B22_08765	COG3170	Tfp pilus assembly protein FimV
E1B22_08765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E1B22_08775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E1B22_08785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E1B22_08790	COG0196	riboflavin kinase activity
E1B22_08795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E1B22_08800	COG1185	polyribonucleotide nucleotidyltransferase activity
E1B22_08805	COG0612	Peptidase, M16
E1B22_08810	COG0756	dUTP diphosphatase activity
E1B22_08825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E1B22_08835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E1B22_08840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E1B22_08845	COG0527	aspartate kinase activity
E1B22_08850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E1B22_08855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E1B22_08860	COG0740	serine-type endopeptidase activity
E1B22_08875	COG1674	ftsk spoiiie
E1B22_08880	COG3858	chitin binding
E1B22_08890	COG1809	phosphosulfolactate synthase activity
E1B22_08905	COG1960	acyl-CoA dehydrogenase activity
E1B22_08910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E1B22_08915	COG1686	Belongs to the peptidase S11 family
E1B22_08920	COG0017	Asparaginyl-tRNA synthetase
E1B22_08925	COG1426	Protein conserved in bacteria
E1B22_08930	COG1686	Belongs to the peptidase S11 family
E1B22_08935	COG0726	polysaccharide deacetylase
E1B22_08945	COG1111	helicase
E1B22_08945	COG1205	dead DEAH box helicase
E1B22_08950	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
E1B22_08955	COG1739	Uncharacterized protein family UPF0029
E1B22_08965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E1B22_08970	COG1058	Belongs to the CinA family
E1B22_08970	COG1546	Belongs to the CinA family
E1B22_08975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E1B22_08985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E1B22_08990	COG2137	regulation of response to DNA damage stimulus
E1B22_09000	COG1692	metallophosphoesterase
E1B22_09010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E1B22_09030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E1B22_09035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E1B22_09040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E1B22_09045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E1B22_09060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E1B22_09065	COG0464	growth
E1B22_09070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E1B22_09080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E1B22_09115	COG0726	polysaccharide deacetylase
E1B22_09125	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E1B22_09130	COG0406	alpha-ribazole phosphatase activity
E1B22_09135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E1B22_09140	COG0402	S-adenosylhomocysteine deaminase activity
E1B22_09145	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E1B22_09150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E1B22_09155	COG0105	UTP biosynthetic process
E1B22_09160	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E1B22_09170	COG0438	transferase activity, transferring glycosyl groups
E1B22_09180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E1B22_09195	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E1B22_09205	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E1B22_09210	COG1160	GTP binding
E1B22_09225	COG0539	negative regulation of cytoplasmic translation
E1B22_09230	COG0204	Acyl-transferase
E1B22_09230	COG0318	PFAM AMP-dependent synthetase and ligase
E1B22_09235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E1B22_09260	COG0644	oxidoreductase
E1B22_09265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E1B22_09280	COG1187	pseudouridine synthase activity
E1B22_09290	COG0700	Nucleoside recognition
E1B22_09295	COG2715	membrane protein required for spore maturation
E1B22_09300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E1B22_09310	COG1793	dna ligase
E1B22_09315	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E1B22_09320	COG3874	Sporulation protein YtfJ
E1B22_09330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E1B22_09335	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E1B22_09340	COG1994	Peptidase M50
E1B22_09345	COG0697	spore germination
E1B22_09355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E1B22_09370	COG1191	sigma factor activity
E1B22_09375	COG2172	sigma factor antagonist activity
E1B22_09380	COG1366	Belongs to the anti-sigma-factor antagonist family
E1B22_09385	COG1686	Belongs to the peptidase S11 family
E1B22_09390	COG1921	L-seryl-tRNASec selenium transferase activity
E1B22_09400	COG0686	Belongs to the AlaDH PNT family
E1B22_09410	COG0494	nUDIX hydrolase
E1B22_09435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E1B22_09455	COG0745	RESPONSE REGULATOR receiver
E1B22_09465	COG0497	DNA recombination
E1B22_09470	COG1438	arginine binding
E1B22_09475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E1B22_09485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E1B22_09490	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E1B22_09500	COG0142	geranyltranstransferase activity
E1B22_09505	COG1722	exodeoxyribonuclease VII activity
E1B22_09510	COG1570	exodeoxyribonuclease VII activity
E1B22_09515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E1B22_09535	COG1302	Protein conserved in bacteria
E1B22_09590	COG0006	proline dipeptidase activity
E1B22_09600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E1B22_09605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E1B22_09610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E1B22_09615	COG0509	glycine decarboxylation via glycine cleavage system
E1B22_09620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E1B22_09635	COG0438	transferase activity, transferring glycosyl groups
E1B22_09705	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E1B22_09710	COG1191	sigma factor activity
E1B22_09715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E1B22_09720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E1B22_09735	COG4472	Bacterial protein of unknown function (DUF965)
E1B22_09740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E1B22_09770	COG1104	cysteine desulfurase activity
E1B22_09775	COG1959	2 iron, 2 sulfur cluster binding
E1B22_09785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E1B22_09790	COG1435	thymidine kinase activity
E1B22_09805	COG3118	belongs to the thioredoxin family
E1B22_09815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E1B22_09820	COG0124	histidyl-tRNA synthetase
E1B22_09825	COG1490	D-aminoacyl-tRNA deacylase activity
E1B22_09830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E1B22_09835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E1B22_09835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E1B22_09850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E1B22_09855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E1B22_09880	COG1051	belongs to the nudix hydrolase family
E1B22_09885	COG3464	Transposase
E1B22_09900	COG1960	acyl-CoA dehydrogenase activity
E1B22_09920	COG0113	porphobilinogen synthase activity
E1B22_09925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E1B22_09925	COG1587	Uroporphyrinogen-III synthase
E1B22_09930	COG0181	hydroxymethylbilane synthase activity
E1B22_09940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E1B22_09945	COG2226	methyltransferase
E1B22_09950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E1B22_09955	COG0045	succinate-CoA ligase (ADP-forming) activity
E1B22_09960	COG0281	malic enzyme
E1B22_09965	COG0039	L-malate dehydrogenase activity
E1B22_09975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E1B22_09990	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E1B22_10000	COG2002	toxin-antitoxin pair type II binding
E1B22_10005	COG4472	Bacterial protein of unknown function (DUF965)
E1B22_10020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E1B22_10025	COG1122	ATPase activity
E1B22_10030	COG1104	cysteine desulfurase activity
E1B22_10035	COG0301	tRNA thio-modification
E1B22_10070	COG0460	homoserine dehydrogenase
E1B22_10075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E1B22_10090	COG1595	DNA-templated transcription, initiation
E1B22_10100	COG1131	(ABC) transporter
E1B22_10125	COG1489	DNA binding
E1B22_10135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E1B22_10140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E1B22_10145	COG1752	Esterase of the alpha-beta hydrolase superfamily
E1B22_10150	COG0697	spore germination
E1B22_10170	COG0372	Belongs to the citrate synthase family
E1B22_10175	COG1120	ATPase activity
E1B22_10180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E1B22_10185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E1B22_10190	COG1902	pentaerythritol trinitrate reductase activity
E1B22_10215	COG1309	transcriptional regulator
E1B22_10225	COG0649	NAD binding
E1B22_10235	COG1744	ABC transporter substrate-binding protein PnrA-like
E1B22_10255	COG1132	(ABC) transporter
E1B22_10260	COG1132	(ABC) transporter
E1B22_10275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E1B22_10280	COG1408	metallophosphoesterase
E1B22_10285	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E1B22_10290	COG1122	ATPase activity
E1B22_10295	COG4721	ABC-type cobalt transport system, permease component
E1B22_10300	COG1028	Short-chain dehydrogenase reductase Sdr
E1B22_10310	COG0318	PFAM AMP-dependent synthetase and ligase
E1B22_10340	COG0561	phosphatase activity
E1B22_10345	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E1B22_10350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E1B22_10355	COG0179	Fumarylacetoacetate (FAA) hydrolase
E1B22_10365	COG2391	methyltransferase activity
E1B22_10375	COG5002	protein histidine kinase activity
E1B22_10380	COG0745	RESPONSE REGULATOR receiver
E1B22_10385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E1B22_10395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E1B22_10415	COG1098	S1 RNA binding domain
E1B22_10425	COG1803	Methylglyoxal synthase
E1B22_10435	COG0674	pyruvate-flavodoxin oxidoreductase activity
E1B22_10435	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E1B22_10440	COG1013	pyruvate-flavodoxin oxidoreductase activity
E1B22_10455	COG2197	response regulator
E1B22_10460	COG4585	Histidine kinase
E1B22_10470	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E1B22_10495	COG0805	protein transport
E1B22_10500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E1B22_10510	COG0612	Peptidase, M16
E1B22_10515	COG0612	Peptidase, M16
E1B22_10525	COG1609	Transcriptional regulator
E1B22_10535	COG0745	RESPONSE REGULATOR receiver
E1B22_10540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E1B22_10545	COG0511	ligase activity, forming carbon-carbon bonds
E1B22_10550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E1B22_10560	COG0302	gtp cyclohydrolase
E1B22_10580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E1B22_10590	COG0277	FAD linked oxidase domain protein
E1B22_10595	COG0247	lactate metabolic process
E1B22_10600	COG0277	FAD linked oxidase domain protein
E1B22_10610	COG0584	glycerophosphoryl diester phosphodiesterase
E1B22_10615	COG0300	oxidoreductase activity
E1B22_10620	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E1B22_10625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E1B22_10665	COG0577	efflux transmembrane transporter activity
E1B22_10665	COG1136	(ABC) transporter
E1B22_10690	COG1309	transcriptional regulator
E1B22_10710	COG0697	spore germination
E1B22_10715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E1B22_10720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E1B22_10720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E1B22_10725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E1B22_10725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E1B22_10730	COG0151	Belongs to the GarS family
E1B22_10735	COG0138	bifunctional purine biosynthesis protein purh
E1B22_10750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E1B22_10770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E1B22_10810	COG1013	pyruvate-flavodoxin oxidoreductase activity
E1B22_10815	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E1B22_10815	COG0674	pyruvate-flavodoxin oxidoreductase activity
E1B22_10825	COG1126	abc transporter atp-binding protein
E1B22_10830	COG0765	amino acid transport
E1B22_10835	COG4597	amino acid ABC transporter
E1B22_10840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E1B22_10845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E1B22_10850	COG2154	pterin-4-alpha-carbinolamine dehydratase
E1B22_10865	COG1090	epimerase
E1B22_10890	COG0159	tryptophan synthase activity
E1B22_10895	COG0133	tryptophan synthase activity
E1B22_10900	COG0135	phosphoribosylanthranilate isomerase activity
E1B22_10905	COG0134	indole-3-glycerol-phosphate synthase activity
E1B22_10910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E1B22_10945	COG0303	'Molybdopterin
E1B22_10950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E1B22_10955	COG0746	molybdenum cofactor guanylyltransferase activity
E1B22_10960	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E1B22_10980	COG0747	negative chemotaxis
E1B22_10995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E1B22_11000	COG2059	Chromate
E1B22_11005	COG0405	Gamma-glutamyltransferase
E1B22_11010	COG0444	Belongs to the ABC transporter superfamily
E1B22_11015	COG4608	Belongs to the ABC transporter superfamily
E1B22_11020	COG2233	PERMEase
E1B22_11025	COG1024	Enoyl-CoA hydratase
E1B22_11030	COG2814	Major facilitator Superfamily
E1B22_11035	COG0674	pyruvate-flavodoxin oxidoreductase activity
E1B22_11035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E1B22_11040	COG1013	pyruvate-flavodoxin oxidoreductase activity
E1B22_11090	COG1216	Glycosyl transferase, family 2
E1B22_11095	COG0489	protein tyrosine kinase activity
E1B22_11100	COG2132	Multicopper oxidase
E1B22_11105	COG1276	copper resistance
E1B22_11120	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E1B22_11145	COG4377	Putative membrane peptidase family (DUF2324)
E1B22_11150	COG1012	belongs to the aldehyde dehydrogenase family
E1B22_11160	COG1063	alcohol dehydrogenase
E1B22_11170	COG1309	transcriptional regulator
E1B22_11175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E1B22_11190	COG0318	PFAM AMP-dependent synthetase and ligase
E1B22_11205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E1B22_11210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E1B22_11220	COG2313	pseudouridylate synthase activity
E1B22_11230	COG0542	response to heat
E1B22_11235	COG1940	carbohydrate kinase activity
E1B22_11245	COG1175	transmembrane transport
E1B22_11250	COG0395	ABC-type sugar transport system, permease component
E1B22_11255	COG1621	beta-fructofuranosidase activity
E1B22_11295	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E1B22_11300	COG1518	maintenance of DNA repeat elements
E1B22_11335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E1B22_11360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E1B22_11370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E1B22_11375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E1B22_11380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E1B22_11385	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
E1B22_11390	COG2217	Heavy metal translocating P-type atpase
E1B22_11395	COG1937	Protein conserved in bacteria
E1B22_11400	COG2217	Heavy metal translocating P-type atpase
E1B22_11415	COG2217	Heavy metal translocating P-type atpase
E1B22_11430	COG2205	protein histidine kinase activity
E1B22_11435	COG0745	RESPONSE REGULATOR receiver
E1B22_11440	COG2132	Multicopper oxidase
E1B22_11450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E1B22_11475	COG2217	Heavy metal translocating P-type atpase
E1B22_11505	COG5002	protein histidine kinase activity
E1B22_11515	COG0745	RESPONSE REGULATOR receiver
E1B22_11520	COG0318	PFAM AMP-dependent synthetase and ligase
E1B22_11545	COG0745	RESPONSE REGULATOR receiver
E1B22_11550	COG2205	protein histidine kinase activity
E1B22_11575	COG0277	FAD linked oxidase domain protein
E1B22_11585	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E1B22_11590	COG0596	Alpha beta hydrolase
E1B22_11625	COG0646	methionine synthase
E1B22_11625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E1B22_11645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E1B22_11655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E1B22_11655	COG1648	precorrin-2 dehydrogenase activity
E1B22_11660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E1B22_11675	COG2046	Belongs to the sulfate adenylyltransferase family
E1B22_11675	COG0529	Catalyzes the synthesis of activated sulfate
E1B22_11680	COG1335	isochorismatase
E1B22_11685	COG0745	RESPONSE REGULATOR receiver
E1B22_11690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E1B22_11695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E1B22_11715	COG2376	Dihydroxyacetone kinase
E1B22_11720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E1B22_11730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E1B22_11735	COG0704	Plays a role in the regulation of phosphate uptake
E1B22_11740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E1B22_11745	COG0581	inorganic phosphate transmembrane transporter activity
E1B22_11750	COG0573	inorganic phosphate transmembrane transporter activity
E1B22_11755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E1B22_11760	COG5002	protein histidine kinase activity
E1B22_11770	COG1993	acr, cog1993
E1B22_11775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E1B22_11785	COG0114	fumarate hydratase activity
E1B22_11810	COG2323	membrane
E1B22_11815	COG2131	deaminase
E1B22_11825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E1B22_11845	COG3377	Domain of unknown function (DUF1805)
E1B22_11850	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E1B22_11875	COG0022	dehydrogenase e1 component
E1B22_11895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E1B22_11915	COG0477	Major facilitator Superfamily
E1B22_11925	COG0477	Major facilitator Superfamily
E1B22_11935	COG0473	3-isopropylmalate dehydrogenase activity
E1B22_11940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E1B22_11950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E1B22_11960	COG1363	Peptidase, m42
E1B22_11965	COG1363	Peptidase, m42
E1B22_11985	COG1263	PTS System
E1B22_11985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E1B22_11985	COG2190	(PTS) system
E1B22_11990	COG1263	PTS System
E1B22_11990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E1B22_12005	COG1827	regulation of RNA biosynthetic process
E1B22_12030	COG0601	transmembrane transport
E1B22_12035	COG4166	transmembrane transport
E1B22_12045	COG0019	diaminopimelate decarboxylase activity
E1B22_12065	COG0640	Transcriptional regulator
E1B22_12070	COG5658	integral membrane protein
E1B22_12095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E1B22_12100	COG0494	nUDIX hydrolase
E1B22_12110	COG1028	Short-chain dehydrogenase reductase Sdr
E1B22_12120	COG1139	Iron-sulfur cluster binding protein
E1B22_12140	COG1131	(ABC) transporter
E1B22_12260	COG4974	Belongs to the 'phage' integrase family
E1B22_12300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E1B22_12305	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E1B22_12310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E1B22_12325	COG1492	cobalamin metabolic process
E1B22_12335	COG1492	cobalamin metabolic process
E1B22_12350	COG1192	Involved in chromosome partitioning
E1B22_12360	COG1475	DNA binding
E1B22_12410	COG1131	(ABC) transporter
E1B22_12460	COG4974	Belongs to the 'phage' integrase family
E1B22_12500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E1B22_12510	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E1B22_12535	COG1492	cobalamin metabolic process
E1B22_12555	COG4974	Belongs to the 'phage' integrase family
E1B22_12595	COG4974	Belongs to the 'phage' integrase family