locus-tag	class	description
BR63_00030	COG0739	heme binding
BR63_00030	COG0741	lytic transglycosylase activity
BR63_00030	COG1196	nuclear chromosome segregation
BR63_00085	COG1595	DNA-templated transcription, initiation
BR63_00095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BR63_00095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BR63_00100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BR63_00105	COG0237	dephospho-CoA kinase activity
BR63_00130	COG2135	peptidase activity
BR63_00150	COG0247	lactate metabolic process
BR63_00150	COG2181	nitrate reductase activity
BR63_00160	COG2508	Transcriptional regulator
BR63_00160	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BR63_00175	COG1473	amidohydrolase
BR63_00225	COG3290	protein histidine kinase activity
BR63_00255	COG3290	protein histidine kinase activity
BR63_00265	COG3279	Response regulator of the LytR AlgR family
BR63_00345	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BR63_00350	COG3290	protein histidine kinase activity
BR63_00350	COG3290	protein histidine kinase activity
BR63_00350	COG3829	transcription factor binding
BR63_00350	COG3829	transcription factor binding
BR63_00385	COG0745	RESPONSE REGULATOR receiver
BR63_00390	COG5002	protein histidine kinase activity
BR63_00395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BR63_00400	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BR63_00420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BR63_00425	COG0569	domain protein
BR63_00450	COG1333	cytochrome c biogenesis protein
BR63_00455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BR63_00465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BR63_00485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BR63_00495	COG0719	Fe-S assembly protein
BR63_00500	COG0697	spore germination
BR63_00520	COG3875	lactate racemase activity
BR63_00530	COG2721	sulfolactate sulfo-lyase activity
BR63_00535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BR63_00540	COG0129	dihydroxy-acid dehydratase activity
BR63_00550	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_00550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BR63_00555	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_00570	COG0183	Belongs to the thiolase family
BR63_00575	COG1250	3-hydroxyacyl-CoA dehydrogenase
BR63_00580	COG1024	Enoyl-CoA hydratase
BR63_00585	COG2186	Transcriptional regulator
BR63_00600	COG0456	acetyltransferase
BR63_00600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BR63_00625	COG0730	response to heat
BR63_00640	COG0367	asparagine synthase
BR63_00645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BR63_00660	COG2223	nitrite transmembrane transporter activity
BR63_00665	COG1993	acr, cog1993
BR63_00670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BR63_00680	COG0348	domain, Protein
BR63_00725	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BR63_00730	COG3639	organic phosphonate transmembrane transporter activity
BR63_00760	COG3627	carbon phosphorus lyase activity
BR63_00765	COG4107	phosphonate C-P lyase system protein PhnK
BR63_00770	COG3454	Phosphonate metabolism
BR63_00780	COG4778	phosphonate C-P lyase system protein PhnL
BR63_00785	COG0613	PHP domain protein
BR63_00805	COG1940	carbohydrate kinase activity
BR63_00820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BR63_00825	COG0366	Alpha amylase catalytic
BR63_00825	COG3103	Sh3 type 3 domain protein
BR63_00860	COG2333	competence protein COMEC
BR63_00860	COG0658	competence protein
BR63_00915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BR63_00925	COG1543	Belongs to the glycosyl hydrolase 57 family
BR63_00955	COG1301	dicarboxylic acid transport
BR63_00960	COG1024	Enoyl-CoA hydratase
BR63_00965	COG0427	acetyl-CoA hydrolase
BR63_00970	COG1250	3-hydroxyacyl-CoA dehydrogenase
BR63_00970	COG1024	Enoyl-CoA hydratase
BR63_00975	COG0183	Belongs to the thiolase family
BR63_00980	COG3852	Histidine kinase
BR63_01005	COG3852	Histidine kinase
BR63_01015	COG0730	response to heat
BR63_01020	COG1238	metal cluster binding
BR63_01035	COG1595	DNA-templated transcription, initiation
BR63_01045	COG2204	response regulator
BR63_01055	COG0006	proline dipeptidase activity
BR63_01065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BR63_01090	COG2309	aminopeptidase activity
BR63_01100	COG3835	regulator
BR63_01105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BR63_01105	COG0446	pyridine nucleotide-disulphide oxidoreductase
BR63_01135	COG2414	aldehyde ferredoxin oxidoreductase
BR63_01145	COG0067	glutamate synthase
BR63_01150	COG0069	glutamate synthase activity
BR63_01155	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_01170	COG0174	glutamine synthetase
BR63_01175	COG0347	Belongs to the P(II) protein family
BR63_01180	COG0004	ammonium transporteR
BR63_01200	COG1410	methionine synthase
BR63_01200	COG0646	methionine synthase
BR63_01205	COG4942	peptidase
BR63_01225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BR63_01235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BR63_01245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BR63_01255	COG1988	membrane-bound metal-dependent
BR63_01280	COG1988	membrane-bound metal-dependent
BR63_01305	COG2707	UPF0756 membrane protein
BR63_01310	COG2814	Major facilitator Superfamily
BR63_01325	COG0546	phosphoglycolate phosphatase activity
BR63_01335	COG0494	nUDIX hydrolase
BR63_01340	COG5002	protein histidine kinase activity
BR63_01345	COG0745	RESPONSE REGULATOR receiver
BR63_01355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BR63_01365	COG0835	chemotaxis
BR63_01385	COG1533	DNA photolyase activity
BR63_01390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BR63_01395	COG0860	N-Acetylmuramoyl-L-alanine amidase
BR63_01445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BR63_01475	COG1191	sigma factor activity
BR63_01480	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BR63_01480	COG0165	Argininosuccinate lyase
BR63_01485	COG1191	sigma factor activity
BR63_01495	COG1873	PFAM PRC-barrel domain
BR63_01555	COG1024	Enoyl-CoA hydratase
BR63_01560	COG0436	Aminotransferase
BR63_01580	COG1271	oxidase subunit
BR63_01585	COG1294	oxidase, subunit
BR63_01590	COG4988	ABC transporter
BR63_01595	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BR63_01610	COG2340	Cysteine-rich secretory protein family
BR63_01640	COG0457	Tetratricopeptide repeat
BR63_01640	COG0463	Glycosyl transferase, family 2
BR63_01645	COG0457	Tetratricopeptide repeat
BR63_01645	COG0463	Glycosyl transferase, family 2
BR63_01685	COG2340	Cysteine-rich secretory protein family
BR63_01720	COG1496	oxidoreductase activity
BR63_01725	COG0745	RESPONSE REGULATOR receiver
BR63_01730	COG5002	protein histidine kinase activity
BR63_01735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BR63_01750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BR63_01755	COG1799	cell septum assembly
BR63_01760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BR63_01765	COG0762	integral membrane protein
BR63_01775	COG3599	regulation of cell shape
BR63_01780	COG1872	DUF167
BR63_01785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BR63_01790	COG3275	phosphorelay sensor kinase activity
BR63_01795	COG3279	Response regulator of the LytR AlgR family
BR63_01815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BR63_01820	COG4770	biotin carboxylase activity
BR63_01825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BR63_01835	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_01840	COG1063	alcohol dehydrogenase
BR63_01850	COG1414	Transcriptional regulator
BR63_01855	COG2081	HI0933 family
BR63_01865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BR63_01870	COG0509	glycine decarboxylation via glycine cleavage system
BR63_01875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BR63_01880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BR63_01895	COG3344	reverse transcriptase
BR63_01900	COG1802	Transcriptional regulator
BR63_01905	COG4948	Mandelate Racemase Muconate Lactonizing
BR63_01935	COG2414	aldehyde ferredoxin oxidoreductase
BR63_01980	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BR63_01985	COG0347	Belongs to the P(II) protein family
BR63_01990	COG0347	Belongs to the P(II) protein family
BR63_02035	COG3842	ATPase activity
BR63_02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BR63_02055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BR63_02065	COG0516	GMP reductase activity
BR63_02065	COG0517	IMP dehydrogenase activity
BR63_02075	COG0411	ABC transporter
BR63_02090	COG0683	leucine binding
BR63_02095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BR63_02100	COG1116	anion transmembrane transporter activity
BR63_02105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BR63_02115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BR63_02180	COG5012	cobalamin binding
BR63_02195	COG3679	Belongs to the UPF0342 family
BR63_02220	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BR63_02230	COG1363	Peptidase, m42
BR63_02240	COG1489	DNA binding
BR63_02255	COG1484	DNA-dependent DNA replication
BR63_02260	COG1960	acyl-CoA dehydrogenase activity
BR63_02265	COG2086	electron transfer activity
BR63_02270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_02290	COG2001	Belongs to the MraZ family
BR63_02295	COG0275	rRNA processing
BR63_02300	COG3116	cell division
BR63_02305	COG0768	penicillin binding
BR63_02310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BR63_02315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BR63_02320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BR63_02325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BR63_02330	COG0772	Belongs to the SEDS family
BR63_02335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BR63_02340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BR63_02345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BR63_02350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BR63_02355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BR63_02360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BR63_02365	COG4399	Belongs to the UPF0754 family
BR63_02370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BR63_02375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BR63_02385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BR63_02390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BR63_02395	COG0569	domain protein
BR63_02400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BR63_02405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BR63_02410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BR63_02410	COG0072	phenylalanine-tRNA ligase activity
BR63_02415	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BR63_02420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BR63_02420	COG1796	DNA polymerase
BR63_02430	COG0826	peptidase U32
BR63_02435	COG1193	negative regulation of DNA recombination
BR63_02440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BR63_02475	COG4191	Histidine kinase
BR63_02485	COG5002	protein histidine kinase activity
BR63_02495	COG0393	Putative heavy-metal-binding
BR63_02500	COG3584	3D domain protein
BR63_02500	COG3583	domain protein
BR63_02505	COG0217	transcriptional regulatory protein
BR63_02515	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BR63_02520	COG0632	four-way junction helicase activity
BR63_02525	COG2255	four-way junction helicase activity
BR63_02530	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BR63_02540	COG1191	sigma factor activity
BR63_02545	COG2755	lipolytic protein G-D-S-L family
BR63_02550	COG2385	sporulation resulting in formation of a cellular spore
BR63_02555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BR63_02560	COG0343	queuine tRNA-ribosyltransferase activity
BR63_02565	COG1862	Preprotein translocase
BR63_02575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BR63_02580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BR63_02585	COG5416	Lipopolysaccharide assembly protein A domain
BR63_02590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BR63_02590	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BR63_02595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BR63_02605	COG1490	D-aminoacyl-tRNA deacylase activity
BR63_02610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BR63_02615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BR63_02620	COG0124	histidyl-tRNA synthetase
BR63_02625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BR63_02635	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BR63_02640	COG1937	Protein conserved in bacteria
BR63_02645	COG3118	belongs to the thioredoxin family
BR63_02660	COG1959	2 iron, 2 sulfur cluster binding
BR63_02665	COG1104	cysteine desulfurase activity
BR63_02670	COG0822	iron-sulfur transferase activity
BR63_02675	COG0482	sulfurtransferase activity
BR63_02690	COG0628	permease
BR63_02695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BR63_02700	COG4472	Bacterial protein of unknown function (DUF965)
BR63_02705	COG0667	Aldo Keto reductase
BR63_02720	COG3906	Belongs to the UPF0473 family
BR63_02725	COG2720	vancomycin resistance protein
BR63_02730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BR63_02735	COG4122	O-methyltransferase activity
BR63_02740	COG0826	peptidase U32
BR63_02750	COG0768	penicillin binding
BR63_02755	COG0697	spore germination
BR63_02760	COG1283	sodium-dependent phosphate transmembrane transporter activity
BR63_02775	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BR63_02800	COG3275	phosphorelay sensor kinase activity
BR63_02805	COG3279	Response regulator of the LytR AlgR family
BR63_02810	COG2358	TRAP transporter, solute receptor (TAXI family
BR63_02825	COG3829	transcription factor binding
BR63_02825	COG3290	protein histidine kinase activity
BR63_02830	COG2610	gluconate transmembrane transporter activity
BR63_02840	COG2030	dehydratase
BR63_02845	COG0183	Belongs to the thiolase family
BR63_02850	COG1024	Enoyl-CoA hydratase
BR63_02860	COG1414	Transcriptional regulator
BR63_02865	COG0129	dihydroxy-acid dehydratase activity
BR63_02870	COG0800	Aldolase
BR63_02910	COG3620	sequence-specific DNA binding
BR63_02915	COG3620	sequence-specific DNA binding
BR63_02930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BR63_02950	COG1988	membrane-bound metal-dependent
BR63_02995	COG0739	heme binding
BR63_02995	COG0741	lytic transglycosylase activity
BR63_02995	COG1196	nuclear chromosome segregation
BR63_03070	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BR63_03115	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BR63_03205	COG1595	DNA-templated transcription, initiation
BR63_03250	COG3481	metal-dependent phosphohydrolase, HD sub domain
BR63_03295	COG0629	single-stranded DNA binding
BR63_03300	COG0675	Transposase, IS605 OrfB family
BR63_03430	COG0714	Associated with various cellular activities
BR63_03490	COG4974	Belongs to the 'phage' integrase family
BR63_03515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BR63_03545	COG1215	transferase activity, transferring glycosyl groups
BR63_03590	COG1201	RNA secondary structure unwinding
BR63_03600	COG4717	serine-type aminopeptidase activity
BR63_03620	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BR63_03635	COG3481	metal-dependent phosphohydrolase, HD sub domain
BR63_03690	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BR63_03730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BR63_03745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BR63_03750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BR63_03760	COG1459	type II secretion system
BR63_03770	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BR63_03820	COG0312	modulator of DNA gyrase
BR63_03825	COG0312	modulator of DNA gyrase
BR63_03830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BR63_03835	COG0006	proline dipeptidase activity
BR63_03850	COG3854	ATPases associated with a variety of cellular activities
BR63_03890	COG1302	Protein conserved in bacteria
BR63_03905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BR63_03910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BR63_03915	COG0543	2 iron, 2 sulfur cluster binding
BR63_03925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BR63_03930	COG1570	exodeoxyribonuclease VII activity
BR63_03945	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BR63_03950	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BR63_03955	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BR63_03970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BR63_03975	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BR63_03985	COG0497	DNA recombination
BR63_03990	COG0750	zinc metalloprotease
BR63_03995	COG0745	RESPONSE REGULATOR receiver
BR63_04030	COG1379	DNA repair
BR63_04040	COG1300	Membrane
BR63_04045	COG1115	amino acid carrier protein
BR63_04070	COG4974	Belongs to the 'phage' integrase family
BR63_04075	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BR63_04085	COG1686	Belongs to the peptidase S11 family
BR63_04095	COG2172	sigma factor antagonist activity
BR63_04110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BR63_04135	COG0617	tRNA 3'-terminal CCA addition
BR63_04140	COG1994	Peptidase M50
BR63_04145	COG0180	Tryptophanyl-tRNA synthetase
BR63_04150	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BR63_04155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BR63_04165	COG3874	Sporulation protein YtfJ
BR63_04170	COG2715	membrane protein required for spore maturation
BR63_04175	COG0700	Nucleoside recognition
BR63_04180	COG1187	pseudouridine synthase activity
BR63_04195	COG1620	l-lactate permease
BR63_04200	COG0277	FAD linked oxidase domain protein
BR63_04230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BR63_04235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BR63_04240	COG0204	Acyl-transferase
BR63_04245	COG0539	negative regulation of cytoplasmic translation
BR63_04245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BR63_04250	COG1304	FMN binding
BR63_04260	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_04260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BR63_04265	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_04275	COG0156	8-amino-7-oxononanoate synthase activity
BR63_04280	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
BR63_04290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BR63_04305	COG1414	Transcriptional regulator
BR63_04340	COG0071	Belongs to the small heat shock protein (HSP20) family
BR63_04350	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BR63_04355	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BR63_04380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BR63_04385	COG3875	lactate racemase activity
BR63_04425	COG1181	Belongs to the D-alanine--D-alanine ligase family
BR63_04435	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BR63_04440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BR63_04450	COG0464	growth
BR63_04475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BR63_04515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BR63_04585	COG1923	regulation of RNA biosynthetic process
BR63_04590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BR63_04595	COG2521	methyltransferase
BR63_04595	COG2136	Putative SAM-dependent methyltransferase
BR63_04600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BR63_04605	COG0123	including yeast histone deacetylase and acetoin utilization protein
BR63_04615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BR63_04620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BR63_04625	COG1752	Esterase of the alpha-beta hydrolase superfamily
BR63_04635	COG1982	Orn Lys Arg decarboxylase major
BR63_04640	COG1077	Cell shape determining protein MreB Mrl
BR63_04645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BR63_04655	COG0516	GMP reductase activity
BR63_04655	COG0517	IMP dehydrogenase activity
BR63_04670	COG0588	phosphoglycerate mutase activity
BR63_04685	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BR63_04690	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BR63_04695	COG1797	cobyrinic acid a,c-diamide synthase activity
BR63_04705	COG1492	cobalamin metabolic process
BR63_04755	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BR63_04770	COG0613	PHP domain protein
BR63_04780	COG2359	stage V sporulation protein S
BR63_04785	COG1692	metallophosphoesterase
BR63_04795	COG1418	mRNA catabolic process
BR63_04805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BR63_04815	COG0513	Belongs to the DEAD box helicase family
BR63_04825	COG1058	Belongs to the CinA family
BR63_04825	COG1546	Belongs to the CinA family
BR63_04830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BR63_04835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BR63_04840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BR63_04840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BR63_04840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BR63_04850	COG1105	Belongs to the carbohydrate kinase PfkB family
BR63_04855	COG1349	DNA-binding transcription factor activity
BR63_04860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BR63_04870	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BR63_04875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BR63_04880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BR63_04890	COG1426	Protein conserved in bacteria
BR63_04895	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BR63_04900	COG1674	ftsk spoiiie
BR63_04910	COG0740	serine-type endopeptidase activity
BR63_04915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BR63_04920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BR63_04925	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BR63_04930	COG1873	PFAM PRC-barrel domain
BR63_04945	COG0612	Peptidase, M16
BR63_04950	COG1686	Belongs to the peptidase S11 family
BR63_04955	COG0726	polysaccharide deacetylase
BR63_04960	COG1185	polyribonucleotide nucleotidyltransferase activity
BR63_04965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BR63_04980	COG0196	riboflavin kinase activity
BR63_04985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BR63_04990	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BR63_04995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BR63_05000	COG3064	Membrane
BR63_05000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BR63_05000	COG3064	Membrane
BR63_05000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BR63_05010	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BR63_05015	COG0195	Participates in both transcription termination and antitermination
BR63_05020	COG0779	Required for maturation of 30S ribosomal subunits
BR63_05030	COG1285	pathogenesis
BR63_05035	COG0463	Glycosyl transferase, family 2
BR63_05040	COG0442	prolyl-tRNA aminoacylation
BR63_05045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BR63_05050	COG0750	zinc metalloprotease
BR63_05055	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BR63_05060	COG0628	permease
BR63_05065	COG4589	Belongs to the CDS family
BR63_05080	COG0233	cytoplasmic translational termination
BR63_05085	COG0528	UMP kinase activity
BR63_05090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BR63_05095	COG0052	Belongs to the universal ribosomal protein uS2 family
BR63_05115	COG1191	sigma factor activity
BR63_05120	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BR63_05125	COG1776	CheC inhibitor of MCP methylation
BR63_05130	COG0835	chemotaxis
BR63_05135	COG2198	Histidine kinase
BR63_05135	COG0643	Histidine kinase
BR63_05140	COG2201	protein-glutamate methylesterase activity
BR63_05155	COG1419	protein localization to endoplasmic reticulum
BR63_05160	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BR63_05165	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BR63_05170	COG1684	flagellar biosynthetic protein fliR
BR63_05175	COG1987	bacterial-type flagellum assembly
BR63_05180	COG1338	Plays a role in the flagellum-specific transport system
BR63_05185	COG3190	flagellar
BR63_05190	COG2201	protein-glutamate methylesterase activity
BR63_05195	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BR63_05195	COG1776	CheC inhibitor of MCP methylation
BR63_05200	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BR63_05205	COG1580	Controls the rotational direction of flagella during chemotaxis
BR63_05220	COG1582	Flagellar protein (FlbD)
BR63_05235	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BR63_05255	COG1157	protein secretion by the type III secretion system
BR63_05265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BR63_05270	COG1766	The M ring may be actively involved in energy transduction
BR63_05275	COG1677	Flagellar hook-basal body complex protein FliE
BR63_05280	COG1558	bacterial-type flagellum-dependent cell motility
BR63_05285	COG1815	bacterial-type flagellum-dependent cell motility
BR63_05295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BR63_05300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BR63_05305	COG4974	Belongs to the 'phage' integrase family
BR63_05310	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BR63_05315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BR63_05320	COG0758	DNA mediated transformation
BR63_05325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BR63_05340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BR63_05360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BR63_05365	COG2244	polysaccharide biosynthetic process
BR63_05370	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BR63_05385	COG0302	gtp cyclohydrolase
BR63_05410	COG1183	phosphatidylcholine synthase activity
BR63_05415	COG0688	phosphatidylethanolamine metabolic process
BR63_05420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BR63_05420	COG1199	ATP-dependent helicase activity
BR63_05425	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BR63_05435	COG1694	Mazg nucleotide pyrophosphohydrolase
BR63_05455	COG2223	nitrite transmembrane transporter activity
BR63_05465	COG2257	FlhB HrpN YscU SpaS Family
BR63_05475	COG1307	EDD domain protein, DegV family
BR63_05480	COG1461	Dihydroxyacetone kinase
BR63_05490	COG0735	belongs to the Fur family
BR63_05500	COG0569	domain protein
BR63_05505	COG2827	Endonuclease containing a URI domain
BR63_05510	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BR63_05515	COG2199	diguanylate cyclase activity
BR63_05515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BR63_05530	COG1361	Conserved repeat domain
BR63_05560	COG0425	Belongs to the sulfur carrier protein TusA family
BR63_05595	COG3409	Peptidoglycan-binding domain 1 protein
BR63_05595	COG5632	N-Acetylmuramoyl-L-alanine amidase
BR63_05620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BR63_05730	COG0305	Participates in initiation and elongation during chromosome replication
BR63_05820	COG3620	sequence-specific DNA binding
BR63_05830	COG2856	Zn peptidase
BR63_05900	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BR63_05905	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BR63_05910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BR63_05915	COG0113	porphobilinogen synthase activity
BR63_05925	COG0181	hydroxymethylbilane synthase activity
BR63_05930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BR63_05935	COG1648	precorrin-2 dehydrogenase activity
BR63_05935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BR63_05950	COG0805	protein transport
BR63_05955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BR63_05960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BR63_05970	COG0083	homoserine kinase activity
BR63_05975	COG0460	homoserine dehydrogenase
BR63_05980	COG4492	Belongs to the UPF0735 family
BR63_05985	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BR63_05990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BR63_05995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BR63_06050	COG1164	Oligoendopeptidase f
BR63_06055	COG0606	chelatase, subunit chli
BR63_06065	COG3875	lactate racemase activity
BR63_06075	COG0792	nuclease activity
BR63_06080	COG1007	ATP synthesis coupled electron transport
BR63_06090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BR63_06100	COG0839	Belongs to the complex I subunit 6 family
BR63_06105	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_06110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BR63_06115	COG0649	NAD binding
BR63_06120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_06130	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_06145	COG0681	Belongs to the peptidase S26 family
BR63_06150	COG0335	large ribosomal subunit rRNA binding
BR63_06155	COG0336	Belongs to the RNA methyltransferase TrmD family
BR63_06155	COG4752	Belongs to the RNA methyltransferase TrmD family
BR63_06160	COG0336	Belongs to the RNA methyltransferase TrmD family
BR63_06165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BR63_06180	COG0228	four-way junction DNA binding
BR63_06185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BR63_06190	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BR63_06195	COG0402	S-adenosylhomocysteine deaminase activity
BR63_06205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BR63_06210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BR63_06215	COG0552	protein localization to endoplasmic reticulum
BR63_06220	COG1196	nuclear chromosome segregation
BR63_06230	COG0571	ribonuclease III activity
BR63_06235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BR63_06240	COG2070	2-Nitropropane dioxygenase
BR63_06245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BR63_06250	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_06255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BR63_06265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BR63_06270	COG0416	fatty acid biosynthetic process
BR63_06275	COG2030	dehydratase
BR63_06280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BR63_06290	COG0280	phosphate acetyltransferase
BR63_06300	COG1752	Esterase of the alpha-beta hydrolase superfamily
BR63_06305	COG3314	Sporulation integral membrane protein YlbJ
BR63_06315	COG0742	ribosomal rna small subunit methyltransferase
BR63_06325	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BR63_06345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BR63_06355	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BR63_06360	COG4770	biotin carboxylase activity
BR63_06370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BR63_06375	COG0346	lactoylglutathione lyase activity
BR63_06385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BR63_06385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BR63_06390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BR63_06390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BR63_06400	COG0427	acetyl-CoA hydrolase
BR63_06420	COG0490	domain, Protein
BR63_06420	COG0471	metal ion transport
BR63_06430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BR63_06435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BR63_06445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BR63_06450	COG1162	GTPase activity
BR63_06455	COG0515	serine threonine protein kinase
BR63_06455	COG2815	serine threonine protein kinase
BR63_06460	COG0631	protein serine/threonine phosphatase activity
BR63_06470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BR63_06470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BR63_06475	COG2738	Putative neutral zinc metallopeptidase
BR63_06485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BR63_06490	COG0242	peptide deformylase activity
BR63_06495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BR63_06500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BR63_06505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BR63_06510	COG1758	RNA polymerase activity
BR63_06515	COG0194	GDP metabolic process
BR63_06520	COG2052	Domain of unknown function (DUF370)
BR63_06525	COG1561	YicC-like family, N-terminal region
BR63_06535	COG0409	Hydrogenase expression formation protein
BR63_06540	COG0298	carbon dioxide binding
BR63_06545	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BR63_06550	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BR63_06565	COG1151	hydroxylamine reductase activity
BR63_06575	COG0375	protein maturation
BR63_06585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_06595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_06600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BR63_06605	COG0651	ATP synthesis coupled electron transport
BR63_06620	COG0436	Aminotransferase
BR63_06625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BR63_06630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BR63_06655	COG0673	inositol 2-dehydrogenase activity
BR63_06665	COG1228	amidohydrolase
BR63_06675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_06675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_06680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_06695	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_06700	COG2964	Protein conserved in bacteria
BR63_06705	COG0492	ferredoxin-NADP+ reductase activity
BR63_06710	COG0446	pyridine nucleotide-disulphide oxidoreductase
BR63_06715	COG1797	cobyrinic acid a,c-diamide synthase activity
BR63_06720	COG2920	part of a sulfur-relay system
BR63_06725	COG0247	lactate metabolic process
BR63_06745	COG2221	Nitrite and sulphite reductase 4Fe-4S
BR63_06750	COG2221	Nitrite and sulphite reductase 4Fe-4S
BR63_06760	COG2197	response regulator
BR63_06765	COG4585	Histidine kinase
BR63_06770	COG1396	sequence-specific DNA binding
BR63_06775	COG0583	DNA-binding transcription factor activity
BR63_06780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BR63_06785	COG0564	pseudouridine synthase activity
BR63_06795	COG0778	Nitroreductase
BR63_06810	COG2848	UPF0210 protein
BR63_06815	COG3830	Belongs to the UPF0237 family
BR63_06825	COG3344	reverse transcriptase
BR63_06875	COG1402	creatininase
BR63_06880	COG0778	Nitroreductase
BR63_06890	COG4279	zinc finger
BR63_06895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BR63_06945	COG0010	Belongs to the arginase family
BR63_06950	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BR63_06965	COG0686	Belongs to the AlaDH PNT family
BR63_06990	COG0012	GTP binding
BR63_07000	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BR63_07005	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BR63_07015	COG0398	Pfam SNARE associated Golgi protein
BR63_07020	COG2414	aldehyde ferredoxin oxidoreductase
BR63_07035	COG1074	ATP-dependent DNA helicase activity
BR63_07040	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BR63_07045	COG0440	acetolactate synthase activity
BR63_07050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BR63_07080	COG2080	2 iron, 2 sulfur cluster binding
BR63_07080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BR63_07095	COG1342	Belongs to the UPF0251 family
BR63_07110	COG0446	pyridine nucleotide-disulphide oxidoreductase
BR63_07125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BR63_07130	COG2384	SAM-dependent methyltransferase
BR63_07155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BR63_07160	COG0358	DNA primase activity
BR63_07170	COG0574	Belongs to the PEP-utilizing enzyme family
BR63_07170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BR63_07175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BR63_07180	COG0517	IMP dehydrogenase activity
BR63_07185	COG1760	l-serine dehydratase
BR63_07190	COG1760	l-serine dehydratase
BR63_07195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BR63_07200	COG2030	dehydratase
BR63_07205	COG0751	glycine-tRNA ligase activity
BR63_07210	COG0752	glycyl-tRNA synthetase alpha subunit
BR63_07220	COG1381	Involved in DNA repair and RecF pathway recombination
BR63_07245	COG2197	response regulator
BR63_07250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BR63_07255	COG2239	Acts as a magnesium transporter
BR63_07265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BR63_07290	COG1470	cell adhesion involved in biofilm formation
BR63_07305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BR63_07315	COG1480	7TM receptor with intracellular HD hydrolase
BR63_07320	COG1702	phosphate starvation-inducible protein PhoH
BR63_07350	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BR63_07390	COG4864	UPF0365 protein
BR63_07415	COG0537	adenosine 5'-monophosphoramidase activity
BR63_07420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BR63_07425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BR63_07430	COG2264	protein methyltransferase activity
BR63_07435	COG0484	heat shock protein binding
BR63_07440	COG0443	Heat shock 70 kDa protein
BR63_07445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BR63_07450	COG0459	protein refolding
BR63_07455	COG1420	regulation of RNA biosynthetic process
BR63_07460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BR63_07465	COG0481	GTPase activity
BR63_07470	COG0728	peptidoglycan biosynthetic process
BR63_07500	COG3437	response regulator, receiver
BR63_07505	COG2202	Pas domain
BR63_07505	COG2205	protein histidine kinase activity
BR63_07510	COG2197	response regulator
BR63_07525	COG0268	Binds directly to 16S ribosomal RNA
BR63_07530	COG1466	dna polymerase III delta subunit
BR63_07535	COG1686	Belongs to the peptidase S11 family
BR63_07545	COG2333	competence protein COMEC
BR63_07545	COG0658	competence protein
BR63_07565	COG0495	leucyl-tRNA aminoacylation
BR63_07590	COG2226	methyltransferase
BR63_07595	COG0799	negative regulation of ribosome biogenesis
BR63_07600	COG1713	HD superfamily hydrolase involved in NAD metabolism
BR63_07605	COG0724	RNA recognition motif
BR63_07610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BR63_07615	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BR63_07620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BR63_07625	COG1534	Rna-binding protein
BR63_07630	COG0577	efflux transmembrane transporter activity
BR63_07635	COG1136	(ABC) transporter
BR63_07645	COG1983	PspC domain protein
BR63_07650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BR63_07660	COG2011	ABC-type metal ion transport system permease component
BR63_07680	COG0840	transmembrane signaling receptor activity
BR63_07690	COG0569	domain protein
BR63_07695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BR63_07730	COG1151	hydroxylamine reductase activity
BR63_07735	COG0824	Thioesterase
BR63_07750	COG0163	prenyltransferase activity
BR63_07755	COG0521	Mo-molybdopterin cofactor biosynthetic process
BR63_07760	COG0315	cyclic pyranopterin monophosphate synthase activity
BR63_07765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BR63_07770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BR63_07780	COG1910	domain protein
BR63_07785	COG0303	'Molybdopterin
BR63_07790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BR63_07810	COG1051	belongs to the nudix hydrolase family
BR63_07820	COG3706	GGDEF domain
BR63_07830	COG3409	Peptidoglycan-binding domain 1 protein
BR63_07830	COG5632	N-Acetylmuramoyl-L-alanine amidase
BR63_07835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BR63_07865	COG1942	4-Oxalocrotonate Tautomerase
BR63_07885	COG0697	spore germination
BR63_07900	COG2226	methyltransferase
BR63_07905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BR63_07910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BR63_07920	COG1809	phosphosulfolactate synthase activity
BR63_07925	COG2045	Belongs to the ComB family
BR63_07955	COG3875	lactate racemase activity
BR63_07960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BR63_07965	COG0066	3-isopropylmalate dehydratase activity
BR63_07970	COG0179	Fumarylacetoacetate (FAA) hydrolase
BR63_07975	COG0398	Pfam SNARE associated Golgi protein
BR63_07985	COG2186	Transcriptional regulator
BR63_07995	COG2086	electron transfer activity
BR63_08000	COG1960	acyl-CoA dehydrogenase activity
BR63_08010	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_08010	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_08010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BR63_08010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_08015	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_08020	COG2086	electron transfer activity
BR63_08025	COG1960	acyl-CoA dehydrogenase activity
BR63_08030	COG3829	transcription factor binding
BR63_08030	COG3290	protein histidine kinase activity
BR63_08035	COG2205	protein histidine kinase activity
BR63_08040	COG0745	RESPONSE REGULATOR receiver
BR63_08050	COG3852	Histidine kinase
BR63_08055	COG2204	response regulator
BR63_08060	COG2031	fatty acid transporter
BR63_08065	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BR63_08075	COG0159	tryptophan synthase activity
BR63_08090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BR63_08100	COG0584	glycerophosphoryl diester phosphodiesterase
BR63_08110	COG0395	ABC-type sugar transport system, permease component
BR63_08115	COG1175	transmembrane transport
BR63_08120	COG3842	ATPase activity
BR63_08130	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BR63_08140	COG0133	tryptophan synthase activity
BR63_08145	COG0135	phosphoribosylanthranilate isomerase activity
BR63_08155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BR63_08160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BR63_08165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BR63_08165	COG0512	Glutamine amidotransferase of anthranilate synthase
BR63_08195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BR63_08200	COG3958	Transketolase
BR63_08205	COG3959	Transketolase, thiamine diphosphate binding domain
BR63_08210	COG0745	RESPONSE REGULATOR receiver
BR63_08220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BR63_08255	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BR63_08260	COG3246	L-lysine catabolic process to acetate
BR63_08265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BR63_08270	COG2358	TRAP transporter, solute receptor (TAXI family
BR63_08280	COG2358	TRAP transporter, solute receptor (TAXI family
BR63_08315	COG1242	4 iron, 4 sulfur cluster binding
BR63_08330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_08335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_08340	COG0167	dihydroorotate dehydrogenase activity
BR63_08345	COG0543	2 iron, 2 sulfur cluster binding
BR63_08350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BR63_08355	COG2508	Transcriptional regulator
BR63_08360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BR63_08365	COG0284	orotidine-5'-phosphate decarboxylase activity
BR63_08370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BR63_08375	COG0505	Belongs to the CarA family
BR63_08380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BR63_08385	COG0540	Belongs to the ATCase OTCase family
BR63_08395	COG1942	4-Oxalocrotonate Tautomerase
BR63_08415	COG2414	aldehyde ferredoxin oxidoreductase
BR63_08420	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_08445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_08450	COG1063	alcohol dehydrogenase
BR63_08455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BR63_08460	COG1882	Formate acetyltransferase
BR63_08465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_08465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_08470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_08470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_08480	COG3275	phosphorelay sensor kinase activity
BR63_08485	COG3279	Response regulator of the LytR AlgR family
BR63_08495	COG1966	Carbon starvation protein
BR63_08500	COG2814	Major facilitator Superfamily
BR63_08520	COG0640	Transcriptional regulator
BR63_08535	COG1924	4 iron, 4 sulfur cluster binding
BR63_08560	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BR63_08565	COG1666	GTP binding
BR63_08585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BR63_08595	COG2323	membrane
BR63_08605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BR63_08625	COG5564	TIM-barrel signal transduction protein
BR63_08635	COG2204	response regulator
BR63_08640	COG0800	Aldolase
BR63_08645	COG1063	alcohol dehydrogenase
BR63_08650	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_08655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BR63_08660	COG0129	dihydroxy-acid dehydratase activity
BR63_08665	COG1070	Carbohydrate kinase
BR63_08670	COG1737	Transcriptional regulator
BR63_08675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_08680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_08685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_08695	COG0459	protein refolding
BR63_08700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BR63_08705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BR63_08710	COG3328	transposase activity
BR63_08725	COG5609	conserved protein (DUF2294)
BR63_08730	COG2223	nitrite transmembrane transporter activity
BR63_08735	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BR63_08745	COG1012	belongs to the aldehyde dehydrogenase family
BR63_08745	COG1454	alcohol dehydrogenase
BR63_08755	COG3300	MHYT domain
BR63_08755	COG5001	Diguanylate cyclase
BR63_08770	COG3300	MHYT domain
BR63_08770	COG5001	Diguanylate cyclase
BR63_08795	COG1366	Belongs to the anti-sigma-factor antagonist family
BR63_08805	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BR63_08840	COG0277	FAD linked oxidase domain protein
BR63_08850	COG0277	FAD linked oxidase domain protein
BR63_08855	COG0471	metal ion transport
BR63_08860	COG3279	Response regulator of the LytR AlgR family
BR63_08865	COG3275	phosphorelay sensor kinase activity
BR63_08920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BR63_08935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BR63_08950	COG1473	amidohydrolase
BR63_08960	COG0277	FAD linked oxidase domain protein
BR63_08965	COG0247	lactate metabolic process
BR63_08980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BR63_08995	COG4942	peptidase
BR63_09000	COG0428	transporter
BR63_09010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BR63_09010	COG2199	diguanylate cyclase activity
BR63_09020	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
BR63_09025	COG0310	cobalt ion transport
BR63_09030	COG0803	Belongs to the bacterial solute-binding protein 9 family
BR63_09035	COG1121	(ABC) transporter
BR63_09040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BR63_09060	COG1024	Enoyl-CoA hydratase
BR63_09065	COG0443	Heat shock 70 kDa protein
BR63_09070	COG0484	heat shock protein binding
BR63_09080	COG0542	response to heat
BR63_09095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BR63_09105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BR63_09120	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BR63_09120	COG3608	succinylglutamate desuccinylase aspartoacylase
BR63_09160	COG2414	aldehyde ferredoxin oxidoreductase
BR63_09175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BR63_09185	COG2267	carboxylic ester hydrolase activity
BR63_09190	COG0519	Catalyzes the synthesis of GMP from XMP
BR63_09195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BR63_09220	COG2233	PERMEase
BR63_09235	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BR63_09240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BR63_09245	COG0549	Belongs to the carbamate kinase family
BR63_09255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BR63_09260	COG1304	FMN binding
BR63_09265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BR63_09275	COG2508	Transcriptional regulator
BR63_09285	COG1058	Belongs to the CinA family
BR63_09285	COG1546	Belongs to the CinA family
BR63_09290	COG3608	succinylglutamate desuccinylase aspartoacylase
BR63_09290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BR63_09305	COG1187	pseudouridine synthase activity
BR63_09310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BR63_09310	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BR63_09315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BR63_09360	COG2059	Chromate
BR63_09365	COG2861	carbohydrate metabolic process
BR63_09370	COG4149	molybdate abc transporter
BR63_09375	COG0725	ABC transporter, periplasmic molybdate-binding protein
BR63_09395	COG0697	spore germination
BR63_09430	COG0151	Belongs to the GarS family
BR63_09435	COG0138	bifunctional purine biosynthesis protein purh
BR63_09440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BR63_09450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BR63_09455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BR63_09460	COG0047	phosphoribosylformylglycinamidine synthase activity
BR63_09465	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BR63_09470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BR63_09475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BR63_09485	COG2252	PERMEase
BR63_09500	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_09505	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_09520	COG1414	Transcriptional regulator
BR63_09530	COG0157	Belongs to the NadC ModD family
BR63_09540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BR63_09545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BR63_09545	COG0519	Catalyzes the synthesis of GMP from XMP
BR63_09550	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BR63_09555	COG2855	membrane
BR63_09560	COG1309	transcriptional regulator
BR63_09565	COG0842	Transport permease protein
BR63_09570	COG1131	(ABC) transporter
BR63_09575	COG1131	(ABC) transporter
BR63_09585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BR63_09595	COG3949	Membrane
BR63_09600	COG3829	transcription factor binding
BR63_09615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BR63_09640	COG2333	competence protein COMEC
BR63_09640	COG0658	competence protein
BR63_09645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BR63_09650	COG0321	lipoyl(octanoyl) transferase activity
BR63_09665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BR63_09680	COG0247	lactate metabolic process
BR63_09690	COG2920	part of a sulfur-relay system
BR63_09695	COG2204	response regulator
BR63_09700	COG1342	Belongs to the UPF0251 family
BR63_09715	COG0489	protein tyrosine kinase activity
BR63_09720	COG2894	cell division
BR63_09740	COG0517	IMP dehydrogenase activity
BR63_09745	COG0840	transmembrane signaling receptor activity
BR63_09760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BR63_09770	COG0459	protein refolding
BR63_09775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BR63_09780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BR63_09785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BR63_09790	COG0251	oxidation-reduction process
BR63_09810	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BR63_09820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_09840	COG0456	acetyltransferase
BR63_09845	COG1214	PFAM Peptidase M22, glycoprotease
BR63_09850	COG0802	atpase or kinase
BR63_09855	COG2204	response regulator
BR63_09860	COG1228	amidohydrolase
BR63_09870	COG2183	response to ionizing radiation
BR63_09880	COG2337	Toxic component of a toxin-antitoxin (TA) module
BR63_09885	COG0864	Transcriptional regulator
BR63_09890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BR63_09895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BR63_09895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BR63_09900	COG0736	holo-[acyl-carrier-protein] synthase activity
BR63_09905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BR63_09915	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BR63_09925	COG3856	small basic protein
BR63_09940	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
BR63_09955	COG0739	heme binding
BR63_09965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BR63_09995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_09995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_10000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_10005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_10010	COG3290	protein histidine kinase activity
BR63_10010	COG3829	transcription factor binding
BR63_10025	COG0277	FAD linked oxidase domain protein
BR63_10040	COG1454	alcohol dehydrogenase
BR63_10070	COG0427	acetyl-CoA hydrolase
BR63_10080	COG3290	protein histidine kinase activity
BR63_10080	COG3829	transcription factor binding
BR63_10110	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_10140	COG0473	3-isopropylmalate dehydrogenase activity
BR63_10145	COG0066	3-isopropylmalate dehydratase activity
BR63_10150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BR63_10155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BR63_10160	COG0028	Belongs to the TPP enzyme family
BR63_10170	COG0440	acetolactate synthase activity
BR63_10175	COG0028	Belongs to the TPP enzyme family
BR63_10180	COG0129	dihydroxy-acid dehydratase activity
BR63_10200	COG1704	LemA family
BR63_10210	COG2937	Belongs to the GPAT DAPAT family
BR63_10215	COG2155	Conserved Protein
BR63_10225	COG0746	molybdenum cofactor guanylyltransferase activity
BR63_10230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BR63_10240	COG0494	nUDIX hydrolase
BR63_10245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BR63_10255	COG3260	NADH ubiquinone oxidoreductase 20
BR63_10260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_10265	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BR63_10265	COG3261	NADH dehydrogenase
BR63_10270	COG0651	ATP synthesis coupled electron transport
BR63_10275	COG4237	Hydrogenase 4 membrane
BR63_10280	COG0650	Formate hydrogenlyase subunit 4
BR63_10285	COG0651	ATP synthesis coupled electron transport
BR63_10290	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_10300	COG2116	formate transmembrane transporter activity
BR63_10305	COG0288	reversible hydration of carbon dioxide
BR63_10330	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BR63_10340	COG1331	Highly conserved protein containing a thioredoxin domain
BR63_10360	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BR63_10365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BR63_10370	COG0500	methyltransferase
BR63_10390	COG1429	ligase activity, forming nitrogen-metal bonds
BR63_10410	COG1131	(ABC) transporter
BR63_10415	COG1131	(ABC) transporter
BR63_10420	COG1120	ATPase activity
BR63_10480	COG1396	sequence-specific DNA binding
BR63_10485	COG0840	transmembrane signaling receptor activity
BR63_10490	COG0116	Belongs to the methyltransferase superfamily
BR63_10520	COG3259	Nickel-dependent hydrogenase
BR63_10530	COG0375	protein maturation
BR63_10535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BR63_10540	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BR63_10545	COG0298	carbon dioxide binding
BR63_10555	COG0309	Hydrogenase expression formation protein (HypE)
BR63_10570	COG0095	Lipoate-protein ligase
BR63_10590	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_10600	COG0280	phosphate acetyltransferase
BR63_10605	COG3426	butyrate kinase activity
BR63_10610	COG1414	Transcriptional regulator
BR63_10620	COG2962	Rard protein
BR63_10625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BR63_10655	COG3275	phosphorelay sensor kinase activity
BR63_10660	COG3279	Response regulator of the LytR AlgR family
BR63_10665	COG1966	Carbon starvation protein
BR63_10670	COG5002	protein histidine kinase activity
BR63_10675	COG0745	RESPONSE REGULATOR receiver
BR63_10680	COG2226	methyltransferase
BR63_10690	COG1250	3-hydroxyacyl-CoA dehydrogenase
BR63_10695	COG2030	dehydratase
BR63_10700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_10705	COG2086	electron transfer activity
BR63_10710	COG1960	acyl-CoA dehydrogenase activity
BR63_10715	COG0183	Belongs to the thiolase family
BR63_10725	COG0644	oxidoreductase
BR63_10730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_10740	COG1960	acyl-CoA dehydrogenase activity
BR63_10745	COG0427	acetyl-CoA hydrolase
BR63_10760	COG3829	transcription factor binding
BR63_10760	COG3290	protein histidine kinase activity
BR63_10765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_10765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_10775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_10790	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BR63_10805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BR63_10820	COG2210	Belongs to the sulfur carrier protein TusA family
BR63_10835	COG2608	mercury ion transmembrane transporter activity
BR63_10840	COG2217	Heavy metal translocating P-type atpase
BR63_10855	COG2738	Putative neutral zinc metallopeptidase
BR63_10875	COG0785	Cytochrome C biogenesis protein
BR63_10890	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BR63_10890	COG2199	diguanylate cyclase activity
BR63_10900	COG0745	RESPONSE REGULATOR receiver
BR63_10905	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BR63_10910	COG0409	Hydrogenase expression formation protein
BR63_10915	COG0298	carbon dioxide binding
BR63_10920	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BR63_10925	COG0805	protein transport
BR63_10930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BR63_10935	COG0805	protein transport
BR63_10945	COG0375	protein maturation
BR63_10950	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BR63_10970	COG1191	sigma factor activity
BR63_10990	COG5002	protein histidine kinase activity
BR63_11010	COG0730	response to heat
BR63_11025	COG1846	Transcriptional regulator
BR63_11035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BR63_11045	COG1840	ABC-type Fe3 transport system, periplasmic component
BR63_11050	COG1178	ABC-type Fe3 transport system permease component
BR63_11075	COG3852	Histidine kinase
BR63_11080	COG2204	response regulator
BR63_11090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BR63_11095	COG1914	H( )-stimulated, divalent metal cation uptake system
BR63_11100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BR63_11105	COG1984	allophanate hydrolase subunit 2
BR63_11110	COG4336	lyase activity
BR63_11115	COG1079	Belongs to the binding-protein-dependent transport system permease family
BR63_11120	COG4603	Belongs to the binding-protein-dependent transport system permease family
BR63_11125	COG3845	ABC transporter
BR63_11130	COG1744	ABC transporter substrate-binding protein PnrA-like
BR63_11135	COG1773	rubredoxin
BR63_11135	COG1592	Rubrerythrin
BR63_11140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BR63_11145	COG0745	RESPONSE REGULATOR receiver
BR63_11150	COG1272	protein, Hemolysin III
BR63_11160	COG0739	heme binding
BR63_11270	COG1484	DNA-dependent DNA replication
BR63_11285	COG3723	Recombinational DNA repair protein, rece pathway
BR63_11350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BR63_11355	COG0557	exoribonuclease II activity
BR63_11370	COG1647	Serine aminopeptidase, S33
BR63_11375	COG0667	Aldo Keto reductase
BR63_11380	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BR63_11385	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BR63_11390	COG0148	phosphopyruvate hydratase activity
BR63_11395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BR63_11400	COG0149	triose-phosphate isomerase activity
BR63_11405	COG0126	phosphoglycerate kinase activity
BR63_11420	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BR63_11430	COG0110	maltose O-acetyltransferase activity
BR63_11435	COG2221	Nitrite and sulphite reductase 4Fe-4S
BR63_11445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BR63_11450	COG1660	Displays ATPase and GTPase activities
BR63_11455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BR63_11460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BR63_11465	COG1473	amidohydrolase
BR63_11470	COG1619	proteins homologs of microcin C7 resistance protein MccF
BR63_11485	COG1950	PFAM Membrane protein of
BR63_11490	COG0322	excinuclease ABC activity
BR63_11495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BR63_11500	COG0556	nucleotide-excision repair
BR63_11515	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
BR63_11530	COG0793	Belongs to the peptidase S41A family
BR63_11540	COG2177	Part of the ABC transporter FtsEX involved in
BR63_11545	COG2884	Cell division ATP-binding protein ftsE
BR63_11550	COG3958	Transketolase
BR63_11555	COG3959	Transketolase, thiamine diphosphate binding domain
BR63_11565	COG0653	protein targeting
BR63_11575	COG1278	Cold shock
BR63_11585	COG0765	amino acid transport
BR63_11600	COG1516	flagellar protein fliS
BR63_11605	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BR63_11635	COG3693	PFAM glycoside hydrolase, family 10
BR63_11640	COG1191	sigma factor activity
BR63_11665	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BR63_11670	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BR63_11685	COG1256	bacterial-type flagellum assembly
BR63_11685	COG4786	Flagellar basal body rod
BR63_11745	COG2197	response regulator
BR63_11800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BR63_11815	COG0277	FAD linked oxidase domain protein
BR63_11825	COG0129	dihydroxy-acid dehydratase activity
BR63_11840	COG2721	sulfolactate sulfo-lyase activity
BR63_11845	COG2721	sulfolactate sulfo-lyase activity
BR63_11850	COG2414	aldehyde ferredoxin oxidoreductase
BR63_11860	COG2186	Transcriptional regulator
BR63_11865	COG1063	alcohol dehydrogenase
BR63_11870	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_11875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BR63_11885	COG0022	dehydrogenase e1 component
BR63_11890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BR63_11895	COG0247	lactate metabolic process
BR63_11900	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BR63_11905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BR63_11910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BR63_11915	COG2414	aldehyde ferredoxin oxidoreductase
BR63_11940	COG0395	ABC-type sugar transport system, permease component
BR63_11945	COG1175	transmembrane transport
BR63_11950	COG1653	transport
BR63_11955	COG3842	ATPase activity
BR63_11960	COG2188	Transcriptional regulator
BR63_12055	COG1309	transcriptional regulator
BR63_12060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BR63_12070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BR63_12095	COG3103	Sh3 type 3 domain protein
BR63_12095	COG0860	N-Acetylmuramoyl-L-alanine amidase
BR63_12095	COG4991	sh3 domain protein
BR63_12100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BR63_12105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BR63_12130	COG0726	polysaccharide deacetylase
BR63_12135	COG3634	alkyl hydroperoxide reductase activity
BR63_12180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BR63_12190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BR63_12235	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_12260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BR63_12265	COG2089	acid synthase
BR63_12270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BR63_12275	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BR63_12280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BR63_12295	COG0673	inositol 2-dehydrogenase activity
BR63_12325	COG1316	TRANSCRIPTIONal
BR63_12330	COG1316	TRANSCRIPTIONal
BR63_12370	COG4786	Flagellar basal body rod
BR63_12380	COG1609	Transcriptional regulator
BR63_12400	COG2385	sporulation resulting in formation of a cellular spore
BR63_12405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BR63_12420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BR63_12425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BR63_12435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BR63_12440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BR63_12445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BR63_12450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BR63_12455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BR63_12460	COG0356	it plays a direct role in the translocation of protons across the membrane
BR63_12475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BR63_12485	COG2131	deaminase
BR63_12495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BR63_12500	COG4475	Protein of unknown function (DUF436)
BR63_12505	COG0698	ribose 5-phosphate isomerase
BR63_12515	COG1971	Probably functions as a manganese efflux pump
BR63_12520	COG0009	L-threonylcarbamoyladenylate synthase
BR63_12525	COG0651	ATP synthesis coupled electron transport
BR63_12535	COG0651	ATP synthesis coupled electron transport
BR63_12540	COG0651	ATP synthesis coupled electron transport
BR63_12555	COG2111	Na H antiporter
BR63_12555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BR63_12575	COG1863	multisubunit Na H antiporter MnhE subunit
BR63_12585	COG2890	protein-(glutamine-N5) methyltransferase activity
BR63_12590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BR63_12595	COG3872	metal-dependent enzyme
BR63_12600	COG0254	rRNA binding
BR63_12610	COG1494	fructose-1,6-bisphosphatase
BR63_12615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BR63_12630	COG2204	response regulator
BR63_12635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BR63_12640	COG2348	transferase activity, transferring amino-acyl groups
BR63_12645	COG0504	CTP synthase activity
BR63_12655	COG0018	arginyl-trna synthetase
BR63_12660	COG2959	enzyme of heme biosynthesis
BR63_12680	COG2855	membrane
BR63_12710	COG0728	peptidoglycan biosynthetic process
BR63_12715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BR63_12720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BR63_12725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BR63_12730	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BR63_12735	COG0297	glycogen (starch) synthase activity
BR63_12745	COG0662	Cupin 2, conserved barrel domain protein
BR63_12745	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BR63_12750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BR63_12770	COG0489	protein tyrosine kinase activity
BR63_12825	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BR63_12835	COG0456	acetyltransferase
BR63_12840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BR63_12840	COG3153	acetyltransferase
BR63_12850	COG1078	dGTPase activity
BR63_12855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BR63_12865	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BR63_12875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BR63_12880	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BR63_12900	COG0492	ferredoxin-NADP+ reductase activity
BR63_12905	COG1832	CoA-binding protein
BR63_12910	COG0741	lytic transglycosylase activity
BR63_12910	COG1196	nuclear chromosome segregation
BR63_12910	COG0739	heme binding
BR63_12955	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BR63_12960	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BR63_12965	COG0305	Participates in initiation and elongation during chromosome replication
BR63_12970	COG0470	DNA polymerase III
BR63_12970	COG1067	ATP-dependent peptidase activity
BR63_12975	COG0359	binds to the 23S rRNA
BR63_12980	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BR63_12985	COG4241	membrane
BR63_12995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BR63_13015	COG0668	transmembrane transport
BR63_13040	COG0573	inorganic phosphate transmembrane transporter activity
BR63_13045	COG0573	inorganic phosphate transmembrane transporter activity
BR63_13050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BR63_13060	COG3949	Membrane
BR63_13070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BR63_13085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BR63_13095	COG5298	Protein conserved in bacteria
BR63_13100	COG1501	Belongs to the glycosyl hydrolase 31 family
BR63_13120	COG2223	nitrite transmembrane transporter activity
BR63_13125	COG0445	tRNA wobble uridine modification
BR63_13135	COG0546	phosphoglycolate phosphatase activity
BR63_13140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BR63_13145	COG1737	Transcriptional regulator
BR63_13155	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BR63_13160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BR63_13180	COG2707	UPF0756 membrane protein
BR63_13185	COG1307	EDD domain protein, DegV family
BR63_13205	COG1079	Belongs to the binding-protein-dependent transport system permease family
BR63_13215	COG3845	ABC transporter
BR63_13225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BR63_13275	COG1802	Transcriptional regulator
BR63_13280	COG2414	aldehyde ferredoxin oxidoreductase
BR63_13315	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_13330	COG4948	Mandelate Racemase Muconate Lactonizing
BR63_13345	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BR63_13360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BR63_13385	COG3949	Membrane
BR63_13405	COG0739	heme binding
BR63_13420	COG1811	Na channel or pump
BR63_13445	COG1475	DNA binding
BR63_13450	COG1192	Involved in chromosome partitioning
BR63_13460	COG0357	Ribosomal RNA small subunit methyltransferase G
BR63_13465	COG0445	tRNA wobble uridine modification
BR63_13470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BR63_13475	COG1847	R3H domain protein
BR63_13480	COG0706	membrane insertase activity
BR63_13485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BR63_13500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BR63_13510	COG0592	DNA-directed DNA polymerase activity
BR63_13515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BR63_13525	COG0187	DNA topoisomerase II activity
BR63_13530	COG2204	response regulator
BR63_13535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BR63_13545	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BR63_13555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BR63_13560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BR63_13585	COG0590	tRNA wobble adenosine to inosine editing
BR63_13615	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BR63_13665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BR63_13670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BR63_13675	COG0402	S-adenosylhomocysteine deaminase activity
BR63_13680	COG1609	Transcriptional regulator
BR63_13705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BR63_13710	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BR63_13715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BR63_13780	COG1982	Orn Lys Arg decarboxylase major
BR63_13785	COG3870	Protein conserved in bacteria
BR63_13795	COG0470	DNA polymerase III
BR63_13800	COG1774	PSP1 C-terminal conserved region
BR63_13810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BR63_13815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BR63_13820	COG2002	toxin-antitoxin pair type II binding
BR63_13825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BR63_13825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BR63_13830	COG0084	hydrolase, TatD family'
BR63_13835	COG3584	3D domain protein
BR63_13835	COG3583	domain protein
BR63_13845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BR63_13850	COG3409	Peptidoglycan-binding domain 1 protein
BR63_13850	COG3773	Cell wall hydrolase
BR63_13865	COG4466	Protein conserved in bacteria
BR63_13870	COG2340	Cysteine-rich secretory protein family
BR63_13895	COG1376	ErfK ybiS ycfS ynhG family protein
BR63_13905	COG0704	Plays a role in the regulation of phosphate uptake
BR63_13910	COG0011	TIGRFAM Protein of
BR63_13925	COG2720	vancomycin resistance protein
BR63_13935	COG1404	Belongs to the peptidase S8 family
BR63_13940	COG1470	cell adhesion involved in biofilm formation
BR63_13945	COG0726	polysaccharide deacetylase
BR63_13950	COG0328	RNA-DNA hybrid ribonuclease activity
BR63_13965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BR63_13970	COG0765	amino acid transport
BR63_13990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BR63_13995	COG1869	D-ribose catabolic process
BR63_14000	COG1129	ABC transporter
BR63_14005	COG1172	Belongs to the binding-protein-dependent transport system permease family
BR63_14010	COG1879	ABC-type sugar transport system periplasmic component
BR63_14025	COG3546	catalase activity
BR63_14040	COG1794	racemase activity, acting on amino acids and derivatives
BR63_14055	COG0583	DNA-binding transcription factor activity
BR63_14065	COG1301	dicarboxylic acid transport
BR63_14070	COG0069	glutamate synthase activity
BR63_14085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BR63_14090	COG0022	dehydrogenase e1 component
BR63_14095	COG3199	ATP-NAD kinase
BR63_14100	COG0508	dehydrogenase complex catalyzes the overall conversion of
BR63_14105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BR63_14115	COG0189	ligase activity
BR63_14130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BR63_14135	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BR63_14140	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BR63_14145	COG0512	Glutamine amidotransferase of anthranilate synthase
BR63_14165	COG1737	Transcriptional regulator
BR63_14170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_14175	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_14175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_14180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_14180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_14205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BR63_14210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BR63_14210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BR63_14220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BR63_14220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BR63_14235	COG2076	Multidrug Resistance protein
BR63_14250	COG1695	Transcriptional regulator
BR63_14255	COG0640	Transcriptional regulator
BR63_14260	COG2217	Heavy metal translocating P-type atpase
BR63_14270	COG0017	Asparaginyl-tRNA synthetase
BR63_14275	COG5002	protein histidine kinase activity
BR63_14280	COG1217	gtp-binding protein TYPA
BR63_14295	COG1757	Na H antiporter
BR63_14300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BR63_14310	COG4242	Belongs to the peptidase S51 family
BR63_14315	COG0189	ligase activity
BR63_14315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BR63_14320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BR63_14325	COG1802	Transcriptional regulator
BR63_14335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BR63_14340	COG2088	sporulation resulting in formation of a cellular spore
BR63_14345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BR63_14350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BR63_14355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BR63_14360	COG0193	aminoacyl-tRNA hydrolase activity
BR63_14375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BR63_14385	COG2002	toxin-antitoxin pair type II binding
BR63_14390	COG2244	polysaccharide biosynthetic process
BR63_14395	COG3956	TIGRFAM MazG family protein
BR63_14410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BR63_14415	COG2385	sporulation resulting in formation of a cellular spore
BR63_14445	COG1098	S1 RNA binding domain
BR63_14490	COG2208	phosphoserine phosphatase activity
BR63_14500	COG0037	tRNA processing
BR63_14505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BR63_14510	COG0105	UTP biosynthetic process
BR63_14520	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BR63_14525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BR63_14530	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BR63_14535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BR63_14535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BR63_14545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BR63_14550	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BR63_14555	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BR63_14565	COG4684	Psort location CytoplasmicMembrane, score
BR63_14575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BR63_14595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BR63_14600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BR63_14635	COG4463	regulation of RNA biosynthetic process
BR63_14645	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BR63_14650	COG0542	response to heat
BR63_14655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BR63_14665	COG1329	Transcriptional regulator
BR63_14670	COG4956	integral membrane protein (PIN domain superfamily)
BR63_14675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BR63_14680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BR63_14685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BR63_14690	COG1045	serine acetyltransferase
BR63_14695	COG0215	cysteine-tRNA ligase activity
BR63_14705	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
BR63_14710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BR63_14715	COG3688	RNA-binding protein containing a PIN domain
BR63_14750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BR63_14755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BR63_14760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BR63_14765	COG0250	Participates in transcription elongation, termination and antitermination
BR63_14770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BR63_14775	COG0081	regulation of translation
BR63_14780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BR63_14785	COG0222	ribosome binding
BR63_14795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BR63_14805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BR63_14810	COG0049	tRNA binding
BR63_14815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BR63_14820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BR63_14825	COG0051	transcription antitermination factor activity, RNA binding
BR63_14830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BR63_14835	COG0088	Forms part of the polypeptide exit tunnel
BR63_14840	COG0089	rRNA binding
BR63_14845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BR63_14850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BR63_14855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BR63_14860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BR63_14865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BR63_14870	COG0255	Belongs to the universal ribosomal protein uL29 family
BR63_14880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BR63_14885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BR63_14895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BR63_14900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BR63_14905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BR63_14910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BR63_14915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BR63_14920	COG1841	ribosomal large subunit assembly
BR63_14930	COG0201	protein transport
BR63_14935	COG0563	adenylate kinase activity
BR63_14945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BR63_14960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BR63_14965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BR63_14970	COG0202	RNA polymerase activity
BR63_14980	COG1122	ATPase activity
BR63_14990	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BR63_14995	COG0101	tRNA pseudouridine synthase activity
BR63_15000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BR63_15005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BR63_15010	COG0860	N-Acetylmuramoyl-L-alanine amidase
BR63_15050	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BR63_15050	COG2199	diguanylate cyclase activity
BR63_15060	COG3885	ferrous iron binding
BR63_15060	COG2078	PFAM AMMECR1 domain protein
BR63_15065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BR63_15070	COG0835	chemotaxis
BR63_15080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BR63_15085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BR63_15090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BR63_15095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BR63_15105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BR63_15120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BR63_15125	COG0137	argininosuccinate synthase activity
BR63_15130	COG0165	Argininosuccinate lyase
BR63_15135	COG0730	response to heat
BR63_15140	COG0730	response to heat
BR63_15145	COG0428	transporter
BR63_15165	COG0840	transmembrane signaling receptor activity
BR63_15185	COG2210	Belongs to the sulfur carrier protein TusA family
BR63_15190	COG4129	membrane
BR63_15200	COG0671	phosphoesterase, PA-phosphatase related
BR63_15210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BR63_15220	COG1404	Belongs to the peptidase S8 family
BR63_15230	COG3069	C4-dicarboxylate transmembrane transporter activity
BR63_15245	COG0183	Belongs to the thiolase family
BR63_15250	COG1250	3-hydroxyacyl-CoA dehydrogenase
BR63_15310	COG1773	rubredoxin
BR63_15325	COG0733	neurotransmitter:sodium symporter activity
BR63_15335	COG1301	dicarboxylic acid transport
BR63_15350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BR63_15365	COG1139	Iron-sulfur cluster binding protein
BR63_15370	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BR63_15375	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BR63_15415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BR63_15420	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BR63_15435	COG0697	spore germination
BR63_15450	COG5401	PFAM Sporulation and spore germination
BR63_15460	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BR63_15465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BR63_15470	COG1234	tRNA 3'-trailer cleavage
BR63_15475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BR63_15480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BR63_15525	COG0544	peptidyl-prolyl cis-trans isomerase activity
BR63_15530	COG0740	serine-type endopeptidase activity
BR63_15535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BR63_15545	COG0470	DNA polymerase III
BR63_15545	COG1067	ATP-dependent peptidase activity
BR63_15550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BR63_15555	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BR63_15565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BR63_15575	COG0525	valine-tRNA ligase activity
BR63_15580	COG0285	dihydrofolate synthase activity
BR63_15620	COG0516	GMP reductase activity
BR63_15620	COG0517	IMP dehydrogenase activity
BR63_15630	COG0587	DNA-directed DNA polymerase activity
BR63_15635	COG2205	protein histidine kinase activity
BR63_15645	COG0424	maF-like protein
BR63_15650	COG2003	Belongs to the UPF0758 family
BR63_15655	COG1077	Cell shape determining protein MreB Mrl
BR63_15660	COG1792	Involved in formation and maintenance of cell shape
BR63_15670	COG0768	penicillin binding
BR63_15675	COG0850	regulation of cytokinetic process
BR63_15680	COG2894	cell division
BR63_15690	COG0772	Belongs to the SEDS family
BR63_15715	COG5012	cobalamin binding
BR63_15720	COG1921	L-seryl-tRNASec selenium transferase activity
BR63_15750	COG3858	chitin binding
BR63_15780	COG1141	Ferredoxin
BR63_15790	COG2721	sulfolactate sulfo-lyase activity
BR63_15795	COG2721	sulfolactate sulfo-lyase activity
BR63_15800	COG3290	protein histidine kinase activity
BR63_15800	COG3829	transcription factor binding
BR63_15805	COG1827	regulation of RNA biosynthetic process
BR63_15810	COG4862	establishment of competence for transformation
BR63_15825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BR63_15835	COG1550	Protein conserved in bacteria
BR63_15845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BR63_15870	COG2423	ornithine cyclodeaminase activity
BR63_15905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BR63_15910	COG0066	3-isopropylmalate dehydratase activity
BR63_15920	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BR63_15925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BR63_15935	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BR63_15935	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BR63_15940	COG0281	malic enzyme
BR63_15950	COG0066	3-isopropylmalate dehydratase activity
BR63_15955	COG2188	Transcriptional regulator
BR63_15960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BR63_15965	COG2423	ornithine cyclodeaminase activity
BR63_16010	COG2204	response regulator
BR63_16015	COG1960	acyl-CoA dehydrogenase activity
BR63_16020	COG2086	electron transfer activity
BR63_16025	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_16030	COG0644	oxidoreductase
BR63_16035	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BR63_16040	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BR63_16045	COG0287	Prephenate dehydrogenase
BR63_16050	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BR63_16055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BR63_16060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BR63_16065	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BR63_16100	COG4456	Virulence-associated protein
BR63_16105	COG1487	ribonuclease activity
BR63_16175	COG4109	DRTGG domain
BR63_16185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BR63_16190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BR63_16195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BR63_16215	COG4496	protein, YerC YecD
BR63_16220	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BR63_16235	COG0131	Imidazoleglycerol-phosphate dehydratase
BR63_16245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BR63_16250	COG0107	imidazoleglycerol-phosphate synthase activity
BR63_16255	COG0140	phosphoribosyl-ATP diphosphatase activity
BR63_16255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BR63_16290	COG3275	phosphorelay sensor kinase activity
BR63_16295	COG3279	Response regulator of the LytR AlgR family
BR63_16305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BR63_16315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BR63_16330	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BR63_16335	COG0154	amidase activity
BR63_16340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BR63_16420	COG1361	Conserved repeat domain
BR63_16445	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BR63_16555	COG3177	Filamentation induced by cAMP protein fic
BR63_16690	COG1074	ATP-dependent DNA helicase activity
BR63_16765	COG0835	chemotaxis
BR63_16770	COG0840	transmembrane signaling receptor activity
BR63_16805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BR63_16815	COG0732	type I restriction modification DNA specificity domain
BR63_16825	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BR63_16910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BR63_16915	COG0022	dehydrogenase e1 component
BR63_16920	COG0508	dehydrogenase complex catalyzes the overall conversion of
BR63_16925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BR63_16930	COG0321	lipoyl(octanoyl) transferase activity
BR63_16935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BR63_16945	COG2132	Multicopper oxidase
BR63_16995	COG1278	Cold shock
BR63_17020	COG0071	Belongs to the small heat shock protein (HSP20) family
BR63_17030	COG5002	protein histidine kinase activity
BR63_17165	COG3829	transcription factor binding
BR63_17205	COG1396	sequence-specific DNA binding
BR63_17215	COG0778	Nitroreductase
BR63_17220	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BR63_17225	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BR63_17225	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BR63_17230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_17235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_17240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_17240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_17245	COG0277	FAD linked oxidase domain protein
BR63_17250	COG0277	FAD linked oxidase domain protein
BR63_17255	COG0247	lactate metabolic process
BR63_17260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BR63_17265	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BR63_17270	COG3404	Formiminotransferase-cyclodeaminase
BR63_17275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BR63_17280	COG2116	formate transmembrane transporter activity
BR63_17300	COG0583	DNA-binding transcription factor activity
BR63_17315	COG2855	membrane
BR63_17320	COG0589	response to stress
BR63_17355	COG3706	GGDEF domain
BR63_17365	COG5001	Diguanylate cyclase
BR63_17365	COG3300	MHYT domain
BR63_17370	COG0583	DNA-binding transcription factor activity
BR63_17395	COG1366	Belongs to the anti-sigma-factor antagonist family
BR63_17415	COG0697	spore germination
BR63_17430	COG3290	protein histidine kinase activity
BR63_17435	COG4565	transcriptional regulatory protein
BR63_17445	COG0281	malic enzyme
BR63_17460	COG1053	succinate dehydrogenase
BR63_17470	COG2048	Heterodisulfide reductase, subunit B
BR63_17500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BR63_17520	COG1131	(ABC) transporter
BR63_17540	COG0205	6-phosphofructokinase activity
BR63_17545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BR63_17545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BR63_17550	COG0513	Belongs to the DEAD box helicase family
BR63_17565	COG1773	rubredoxin
BR63_17565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BR63_17570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BR63_17575	COG0280	phosphate acetyltransferase
BR63_17585	COG2731	YhcH YjgK YiaL family protein
BR63_17590	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_17590	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_17590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BR63_17590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_17605	COG0546	phosphoglycolate phosphatase activity
BR63_17610	COG1615	UPF0182 protein
BR63_17645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_17650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_17655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_17655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_17660	COG0129	dihydroxy-acid dehydratase activity
BR63_17665	COG0564	pseudouridine synthase activity
BR63_17680	COG0842	Transport permease protein
BR63_17685	COG0681	Belongs to the peptidase S26 family
BR63_17690	COG2186	Transcriptional regulator
BR63_17695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BR63_17710	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BR63_17715	COG4770	biotin carboxylase activity
BR63_17725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BR63_17730	COG1960	acyl-CoA dehydrogenase activity
BR63_17735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BR63_17745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BR63_17750	COG1250	3-hydroxyacyl-CoA dehydrogenase
BR63_17755	COG1024	Enoyl-CoA hydratase
BR63_17760	COG0006	proline dipeptidase activity
BR63_17765	COG0840	transmembrane signaling receptor activity
BR63_17770	COG2086	electron transfer activity
BR63_17775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_17780	COG3829	transcription factor binding
BR63_17780	COG3290	protein histidine kinase activity
BR63_17785	COG0427	acetyl-CoA hydrolase
BR63_17790	COG0659	secondary active sulfate transmembrane transporter activity
BR63_17800	COG2414	aldehyde ferredoxin oxidoreductase
BR63_17805	COG3829	transcription factor binding
BR63_17805	COG3290	protein histidine kinase activity
BR63_17810	COG3290	protein histidine kinase activity
BR63_17810	COG3829	transcription factor binding
BR63_17820	COG0420	3'-5' exonuclease activity
BR63_17825	COG0419	ATPase involved in DNA repair
BR63_17830	COG1671	Belongs to the UPF0178 family
BR63_17840	COG2814	Major facilitator Superfamily
BR63_17845	COG5002	protein histidine kinase activity
BR63_17850	COG0745	RESPONSE REGULATOR receiver
BR63_17855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BR63_17860	COG1136	(ABC) transporter
BR63_17865	COG0577	efflux transmembrane transporter activity
BR63_17865	COG1136	(ABC) transporter
BR63_17875	COG1414	Transcriptional regulator
BR63_17895	COG1960	acyl-CoA dehydrogenase activity
BR63_17900	COG2086	electron transfer activity
BR63_17905	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_17910	COG0644	oxidoreductase
BR63_17915	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BR63_17925	COG0154	amidase activity
BR63_17950	COG1473	amidohydrolase
BR63_17960	COG1793	dna ligase
BR63_17965	COG3285	dna ligase
BR63_17965	COG1793	dna ligase
BR63_17970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BR63_17975	COG0739	heme binding
BR63_17975	COG1196	nuclear chromosome segregation
BR63_17975	COG0741	lytic transglycosylase activity
BR63_17990	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BR63_18005	COG1696	Membrane protein involved in D-alanine export
BR63_18015	COG0789	Transcriptional regulator
BR63_18020	COG0501	Belongs to the peptidase M48B family
BR63_18025	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BR63_18035	COG1649	PFAM Uncharacterised BCR, COG1649
BR63_18035	COG0726	polysaccharide deacetylase
BR63_18050	COG2972	Histidine kinase
BR63_18055	COG2201	protein-glutamate methylesterase activity
BR63_18115	COG4869	propanediol catabolic process
BR63_18125	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BR63_18130	COG2096	Adenosyltransferase
BR63_18135	COG1012	belongs to the aldehyde dehydrogenase family
BR63_18140	COG4656	Part of a membrane complex involved in electron transport
BR63_18150	COG0640	Transcriptional regulator
BR63_18155	COG4166	transmembrane transport
BR63_18160	COG4608	Belongs to the ABC transporter superfamily
BR63_18165	COG0444	Belongs to the ABC transporter superfamily
BR63_18170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BR63_18175	COG0601	transmembrane transport
BR63_18185	COG3383	formate dehydrogenase (NAD+) activity
BR63_18190	COG1361	Conserved repeat domain
BR63_18195	COG1408	metallophosphoesterase
BR63_18200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BR63_18205	COG1116	anion transmembrane transporter activity
BR63_18215	COG0534	Mate efflux family protein
BR63_18220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BR63_18225	COG0517	IMP dehydrogenase activity
BR63_18225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BR63_18235	COG1802	Transcriptional regulator
BR63_18240	COG4232	protein-disulfide reductase activity
BR63_18250	COG1802	Transcriptional regulator
BR63_18255	COG0473	3-isopropylmalate dehydrogenase activity
BR63_18260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BR63_18265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BR63_18275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BR63_18285	COG1027	Aspartate ammonia-lyase
BR63_18290	COG1160	GTP binding
BR63_18295	COG0436	Aminotransferase
BR63_18300	COG4191	Histidine kinase
BR63_18305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BR63_18315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BR63_18335	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
BR63_18345	COG0444	Belongs to the ABC transporter superfamily
BR63_18350	COG0747	negative chemotaxis
BR63_18360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BR63_18365	COG4608	Belongs to the ABC transporter superfamily
BR63_18370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BR63_18375	COG2186	Transcriptional regulator
BR63_18405	COG0179	Fumarylacetoacetate (FAA) hydrolase
BR63_18410	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_18415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BR63_18420	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BR63_18430	COG3835	regulator
BR63_18440	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_18445	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_18445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BR63_18455	COG3279	Response regulator of the LytR AlgR family
BR63_18470	COG0129	dihydroxy-acid dehydratase activity
BR63_18475	COG1929	Belongs to the glycerate kinase type-1 family
BR63_18490	COG3706	GGDEF domain
BR63_18500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BR63_18525	COG2195	Cleaves the N-terminal amino acid of tripeptides
BR63_18535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BR63_18540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BR63_18580	COG0840	transmembrane signaling receptor activity
BR63_18610	COG1058	Belongs to the CinA family
BR63_18610	COG1546	Belongs to the CinA family
BR63_18620	COG4569	acetaldehyde dehydrogenase (acetylating) activity
BR63_18625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BR63_18635	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BR63_18650	COG1522	sequence-specific DNA binding
BR63_18655	COG1522	sequence-specific DNA binding
BR63_18660	COG0535	radical SAM domain protein
BR63_18680	COG1691	(AIR) carboxylase
BR63_18685	COG1606	tRNA processing
BR63_18695	COG0697	spore germination
BR63_18725	COG1122	ATPase activity
BR63_18740	COG0598	Magnesium transport protein CorA
BR63_18765	COG2200	EAL domain
BR63_18770	COG1136	(ABC) transporter
BR63_18780	COG0577	efflux transmembrane transporter activity
BR63_18780	COG1136	(ABC) transporter
BR63_18785	COG0371	Dehydrogenase
BR63_18790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BR63_18795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BR63_18800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BR63_18815	COG2104	thiamine diphosphate biosynthetic process
BR63_18815	COG2022	thiamine diphosphate biosynthetic process
BR63_18820	COG2022	thiamine diphosphate biosynthetic process
BR63_18830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BR63_18835	COG0351	phosphomethylpyrimidine kinase
BR63_18845	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BR63_18860	COG2070	2-Nitropropane dioxygenase
BR63_18865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BR63_18870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BR63_18875	COG3290	protein histidine kinase activity
BR63_18875	COG3829	transcription factor binding
BR63_18885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_18890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_18895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_18895	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_18900	COG3069	C4-dicarboxylate transmembrane transporter activity
BR63_18905	COG0733	neurotransmitter:sodium symporter activity
BR63_18930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BR63_18935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BR63_18940	COG3437	response regulator, receiver
BR63_18950	COG0516	GMP reductase activity
BR63_18950	COG0517	IMP dehydrogenase activity
BR63_18955	COG5002	protein histidine kinase activity
BR63_18960	COG0745	RESPONSE REGULATOR receiver
BR63_18975	COG0798	PFAM Bile acid sodium symporter
BR63_18985	COG0310	cobalt ion transport
BR63_18995	COG1122	ATPase activity
BR63_19000	COG0671	phosphoesterase, PA-phosphatase related
BR63_19015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BR63_19065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BR63_19065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BR63_19095	COG4974	Belongs to the 'phage' integrase family
BR63_19155	COG4695	Portal protein
BR63_19240	COG3299	homolog of phage Mu protein gp47