locus-tag	class	description
TherJR_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TherJR_0002	COG0592	DNA-directed DNA polymerase activity
TherJR_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TherJR_0008	COG0187	DNA topoisomerase II activity
TherJR_0009	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TherJR_0010	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TherJR_0011	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TherJR_0012	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TherJR_0013	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TherJR_0014	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TherJR_0015	COG0590	tRNA wobble adenosine to inosine editing
TherJR_0017	COG1725	Transcriptional regulator
TherJR_0018	COG1131	(ABC) transporter
TherJR_0020	COG0793	Belongs to the peptidase S41A family
TherJR_0024	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TherJR_0025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TherJR_0027	COG5012	cobalamin binding
TherJR_0031	COG4145	pantothenate transmembrane transporter activity
TherJR_0032	COG4810	utilization protein
TherJR_0034	COG4303	Ethanolamine ammonia lyase large subunit
TherJR_0037	COG4816	utilization protein
TherJR_0039	COG4820	ethanolamine utilization protein (EutJ)
TherJR_0041	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
TherJR_0042	COG4656	Part of a membrane complex involved in electron transport
TherJR_0045	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TherJR_0046	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TherJR_0047	COG1012	belongs to the aldehyde dehydrogenase family
TherJR_0047	COG1454	alcohol dehydrogenase
TherJR_0048	COG4869	propanediol catabolic process
TherJR_0050	COG0163	prenyltransferase activity
TherJR_0051	COG2207	Transcriptional regulator
TherJR_0052	COG5012	cobalamin binding
TherJR_0058	COG5012	cobalamin binding
TherJR_0060	COG0546	phosphoglycolate phosphatase activity
TherJR_0063	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TherJR_0064	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TherJR_0066	COG1564	THIamine pyrophosphokinase
TherJR_0068	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TherJR_0069	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TherJR_0071	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TherJR_0072	COG0077	Prephenate dehydratase
TherJR_0072	COG1605	Chorismate mutase
TherJR_0082	COG0741	lytic transglycosylase activity
TherJR_0084	COG1982	Orn Lys Arg decarboxylase major
TherJR_0085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TherJR_0087	COG0470	DNA polymerase III
TherJR_0088	COG1774	PSP1 C-terminal conserved region
TherJR_0089	COG4467	Involved in initiation control of chromosome replication
TherJR_0090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TherJR_0091	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TherJR_0092	COG2002	toxin-antitoxin pair type II binding
TherJR_0094	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TherJR_0094	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TherJR_0095	COG0084	hydrolase, TatD family'
TherJR_0101	COG3583	domain protein
TherJR_0101	COG3584	3D domain protein
TherJR_0102	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TherJR_0105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TherJR_0106	COG0791	NLP P60 protein
TherJR_0106	COG1388	LysM domain
TherJR_0109	COG0428	transporter
TherJR_0110	COG0835	chemotaxis
TherJR_0111	COG2198	Histidine kinase
TherJR_0111	COG0643	Histidine kinase
TherJR_0112	COG2201	protein-glutamate methylesterase activity
TherJR_0113	COG2201	protein-glutamate methylesterase activity
TherJR_0123	COG0840	transmembrane signaling receptor activity
TherJR_0124	COG1376	ErfK ybiS ycfS ynhG family protein
TherJR_0125	COG4242	Belongs to the peptidase S51 family
TherJR_0127	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TherJR_0128	COG1802	Transcriptional regulator
TherJR_0130	COG2088	sporulation resulting in formation of a cellular spore
TherJR_0131	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TherJR_0132	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TherJR_0133	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TherJR_0139	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TherJR_0140	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TherJR_0148	COG0348	domain, Protein
TherJR_0149	COG1187	pseudouridine synthase activity
TherJR_0150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TherJR_0150	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TherJR_0152	COG1309	transcriptional regulator
TherJR_0154	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TherJR_0154	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TherJR_0156	COG0348	domain, Protein
TherJR_0157	COG1309	transcriptional regulator
TherJR_0158	COG0739	heme binding
TherJR_0162	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TherJR_0165	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TherJR_0173	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TherJR_0175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TherJR_0176	COG0193	aminoacyl-tRNA hydrolase activity
TherJR_0178	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TherJR_0180	COG2002	toxin-antitoxin pair type II binding
TherJR_0181	COG2244	polysaccharide biosynthetic process
TherJR_0182	COG3956	TIGRFAM MazG family protein
TherJR_0184	COG0840	transmembrane signaling receptor activity
TherJR_0185	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TherJR_0186	COG2385	sporulation resulting in formation of a cellular spore
TherJR_0191	COG1098	S1 RNA binding domain
TherJR_0193	COG1309	transcriptional regulator
TherJR_0196	COG0248	Ppx GppA phosphatase
TherJR_0198	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TherJR_0202	COG2208	phosphoserine phosphatase activity
TherJR_0204	COG0037	tRNA processing
TherJR_0205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TherJR_0206	COG0105	UTP biosynthetic process
TherJR_0208	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TherJR_0209	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TherJR_0210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TherJR_0211	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TherJR_0213	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TherJR_0214	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TherJR_0215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TherJR_0216	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TherJR_0217	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TherJR_0218	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TherJR_0223	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TherJR_0223	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TherJR_0224	COG1406	Chemotaxis phosphatase CheX
TherJR_0225	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TherJR_0226	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TherJR_0230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TherJR_0234	COG1053	succinate dehydrogenase
TherJR_0235	COG2508	Transcriptional regulator
TherJR_0236	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TherJR_0241	COG0556	nucleotide-excision repair
TherJR_0242	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TherJR_0243	COG0542	response to heat
TherJR_0245	COG3344	reverse transcriptase
TherJR_0247	COG2208	phosphoserine phosphatase activity
TherJR_0248	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TherJR_0249	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TherJR_0251	COG1329	Transcriptional regulator
TherJR_0252	COG4956	integral membrane protein (PIN domain superfamily)
TherJR_0253	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TherJR_0254	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TherJR_0257	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TherJR_0260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TherJR_0261	COG1309	transcriptional regulator
TherJR_0263	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TherJR_0266	COG4086	secreted protein
TherJR_0268	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TherJR_0269	COG1045	serine acetyltransferase
TherJR_0270	COG0215	cysteine-tRNA ligase activity
TherJR_0271	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TherJR_0273	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TherJR_0274	COG3688	RNA-binding protein containing a PIN domain
TherJR_0276	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TherJR_0280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TherJR_0282	COG0250	Participates in transcription elongation, termination and antitermination
TherJR_0283	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TherJR_0284	COG0081	regulation of translation
TherJR_0285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TherJR_0286	COG0222	ribosome binding
TherJR_0288	COG0085	RNA polymerase activity
TherJR_0289	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TherJR_0290	COG1358	cellular component organization or biogenesis
TherJR_0291	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TherJR_0292	COG0049	tRNA binding
TherJR_0293	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TherJR_0294	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TherJR_0295	COG0051	transcription antitermination factor activity, RNA binding
TherJR_0296	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TherJR_0297	COG0088	Forms part of the polypeptide exit tunnel
TherJR_0298	COG0089	rRNA binding
TherJR_0299	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TherJR_0301	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TherJR_0302	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TherJR_0303	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TherJR_0304	COG0255	Belongs to the universal ribosomal protein uL29 family
TherJR_0305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TherJR_0306	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TherJR_0307	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TherJR_0309	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TherJR_0310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TherJR_0311	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TherJR_0312	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TherJR_0313	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TherJR_0314	COG1841	ribosomal large subunit assembly
TherJR_0315	COG0200	Binds to the 23S rRNA
TherJR_0316	COG0201	protein transport
TherJR_0317	COG0024	Methionine aminopeptidase
TherJR_0319	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TherJR_0320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TherJR_0321	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TherJR_0322	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TherJR_0323	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TherJR_0324	COG0202	RNA polymerase activity
TherJR_0325	COG0203	ribosomal protein L17
TherJR_0327	COG1122	ATPase activity
TherJR_0328	COG1122	ATPase activity
TherJR_0329	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TherJR_0330	COG0101	tRNA pseudouridine synthase activity
TherJR_0331	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TherJR_0335	COG0860	N-Acetylmuramoyl-L-alanine amidase
TherJR_0336	COG3885	ferrous iron binding
TherJR_0336	COG2078	PFAM AMMECR1 domain protein
TherJR_0341	COG0697	spore germination
TherJR_0343	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TherJR_0346	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TherJR_0347	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TherJR_0350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TherJR_0351	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TherJR_0352	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TherJR_0353	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TherJR_0356	COG0165	Argininosuccinate lyase
TherJR_0357	COG0527	aspartate kinase activity
TherJR_0360	COG0028	Belongs to the TPP enzyme family
TherJR_0361	COG0440	acetolactate synthase activity
TherJR_0362	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TherJR_0363	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TherJR_0364	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TherJR_0365	COG0066	3-isopropylmalate dehydratase activity
TherJR_0366	COG0473	3-isopropylmalate dehydrogenase activity
TherJR_0367	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TherJR_0368	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TherJR_0370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TherJR_0371	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TherJR_0372	COG0739	heme binding
TherJR_0372	COG0741	lytic transglycosylase activity
TherJR_0372	COG1196	nuclear chromosome segregation
TherJR_0374	COG3856	small basic protein
TherJR_0376	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TherJR_0378	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TherJR_0379	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TherJR_0412	COG3706	GGDEF domain
TherJR_0412	COG0745	RESPONSE REGULATOR receiver
TherJR_0421	COG2323	membrane
TherJR_0422	COG3459	Glycosyltransferase 36 associated
TherJR_0423	COG0653	protein targeting
TherJR_0424	COG3706	GGDEF domain
TherJR_0431	COG0326	Molecular chaperone. Has ATPase activity
TherJR_0437	COG0537	adenosine 5'-monophosphoramidase activity
TherJR_0440	COG1592	Rubrerythrin
TherJR_0441	COG2033	superoxide reductase activity
TherJR_0443	COG0640	Transcriptional regulator
TherJR_0450	COG0640	Transcriptional regulator
TherJR_0452	COG2897	thiosulfate sulfurtransferase activity
TherJR_0453	COG2814	Major facilitator Superfamily
TherJR_0454	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TherJR_0455	COG1230	cation diffusion facilitator family transporter
TherJR_0456	COG0640	Transcriptional regulator
TherJR_0460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TherJR_0465	COG1595	DNA-templated transcription, initiation
TherJR_0471	COG0640	Transcriptional regulator
TherJR_0472	COG0798	PFAM Bile acid sodium symporter
TherJR_0474	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TherJR_0476	COG0586	Pfam SNARE associated Golgi protein
TherJR_0482	COG0728	peptidoglycan biosynthetic process
TherJR_0483	COG1595	DNA-templated transcription, initiation
TherJR_0486	COG0586	Pfam SNARE associated Golgi protein
TherJR_0494	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TherJR_0495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TherJR_0497	COG2897	thiosulfate sulfurtransferase activity
TherJR_0498	COG0463	Glycosyl transferase, family 2
TherJR_0500	COG2076	Multidrug Resistance protein
TherJR_0503	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TherJR_0504	COG1116	anion transmembrane transporter activity
TherJR_0507	COG0425	Belongs to the sulfur carrier protein TusA family
TherJR_0511	COG0583	DNA-binding transcription factor activity
TherJR_0516	COG0784	Response regulator, receiver
TherJR_0516	COG5002	protein histidine kinase activity
TherJR_0516	COG2198	Histidine kinase
TherJR_0518	COG0671	phosphoesterase, PA-phosphatase related
TherJR_0522	COG2226	methyltransferase
TherJR_0525	COG0427	acetyl-CoA hydrolase
TherJR_0526	COG0583	DNA-binding transcription factor activity
TherJR_0528	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TherJR_0537	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TherJR_0542	COG1309	transcriptional regulator
TherJR_0543	COG2197	response regulator
TherJR_0544	COG0247	lactate metabolic process
TherJR_0544	COG2181	nitrate reductase activity
TherJR_0545	COG1032	radical SAM domain protein
TherJR_0547	COG2890	protein-(glutamine-N5) methyltransferase activity
TherJR_0548	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TherJR_0549	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TherJR_0550	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TherJR_0551	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TherJR_0552	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TherJR_0553	COG0789	Transcriptional regulator
TherJR_0555	COG2197	response regulator
TherJR_0556	COG1404	Belongs to the peptidase S8 family
TherJR_0562	COG1404	Belongs to the peptidase S8 family
TherJR_0569	COG1404	Belongs to the peptidase S8 family
TherJR_0579	COG1331	Highly conserved protein containing a thioredoxin domain
TherJR_0581	COG2814	Major facilitator Superfamily
TherJR_0585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TherJR_0586	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TherJR_0587	COG1993	acr, cog1993
TherJR_0590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TherJR_0597	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
TherJR_0600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TherJR_0601	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TherJR_0602	COG1116	anion transmembrane transporter activity
TherJR_0603	COG0010	Belongs to the arginase family
TherJR_0605	COG0831	urea catabolic process
TherJR_0609	COG0830	nickel cation binding
TherJR_0610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TherJR_0613	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TherJR_0614	COG2972	Histidine kinase
TherJR_0615	COG3279	Response regulator of the LytR AlgR family
TherJR_0616	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TherJR_0623	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TherJR_0624	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TherJR_0625	COG4869	propanediol catabolic process
TherJR_0626	COG4820	ethanolamine utilization protein (EutJ)
TherJR_0628	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
TherJR_0630	COG1012	belongs to the aldehyde dehydrogenase family
TherJR_0631	COG4656	Part of a membrane complex involved in electron transport
TherJR_0633	COG0371	Dehydrogenase
TherJR_0634	COG1380	Effector of murein hydrolase LrgA
TherJR_0635	COG1346	cytolysis
TherJR_0636	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TherJR_0645	COG1388	LysM domain
TherJR_0645	COG3858	chitin binding
TherJR_0646	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TherJR_0648	COG4869	propanediol catabolic process
TherJR_0651	COG3275	phosphorelay sensor kinase activity
TherJR_0653	COG0835	chemotaxis
TherJR_0654	COG0736	holo-[acyl-carrier-protein] synthase activity
TherJR_0655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TherJR_0655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TherJR_0657	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TherJR_0659	COG3707	response regulator
TherJR_0665	COG0367	asparagine synthase
TherJR_0675	COG1598	PFAM Uncharacterised protein family UPF0150
TherJR_0683	COG3177	Filamentation induced by cAMP protein fic
TherJR_0688	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TherJR_0689	COG0347	Belongs to the P(II) protein family
TherJR_0690	COG0347	Belongs to the P(II) protein family
TherJR_0695	COG0535	radical SAM domain protein
TherJR_0695	COG1433	Dinitrogenase iron-molybdenum cofactor
TherJR_0698	COG0725	ABC transporter, periplasmic molybdate-binding protein
TherJR_0699	COG4149	molybdate abc transporter
TherJR_0700	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TherJR_0701	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TherJR_0702	COG0004	ammonium transporteR
TherJR_0703	COG0347	Belongs to the P(II) protein family
TherJR_0705	COG0004	ammonium transporteR
TherJR_0706	COG0347	Belongs to the P(II) protein family
TherJR_0711	COG0067	glutamate synthase
TherJR_0712	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TherJR_0712	COG0069	glutamate synthase activity
TherJR_0713	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TherJR_0714	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TherJR_0716	COG0864	Transcriptional regulator
TherJR_0717	COG2337	Toxic component of a toxin-antitoxin (TA) module
TherJR_0718	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TherJR_0722	COG1228	amidohydrolase
TherJR_0724	COG0351	phosphomethylpyrimidine kinase
TherJR_0724	COG0352	thiamine-phosphate diphosphorylase activity
TherJR_0725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TherJR_0726	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TherJR_0727	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TherJR_0728	COG0802	atpase or kinase
TherJR_0729	COG1214	PFAM Peptidase M22, glycoprotease
TherJR_0730	COG0456	acetyltransferase
TherJR_0734	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TherJR_0735	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TherJR_0739	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TherJR_0740	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TherJR_0743	COG3383	formate dehydrogenase (NAD+) activity
TherJR_0744	COG3383	formate dehydrogenase (NAD+) activity
TherJR_0746	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TherJR_0749	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TherJR_0752	COG1921	L-seryl-tRNASec selenium transferase activity
TherJR_0753	COG0709	Synthesizes selenophosphate from selenide and ATP
TherJR_0754	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TherJR_0755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TherJR_0757	COG0303	'Molybdopterin
TherJR_0758	COG1910	domain protein
TherJR_0759	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TherJR_0760	COG0315	cyclic pyranopterin monophosphate synthase activity
TherJR_0762	COG0521	Mo-molybdopterin cofactor biosynthetic process
TherJR_0763	COG3604	Transcriptional regulator
TherJR_0765	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TherJR_0766	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TherJR_0767	COG0437	4 iron, 4 sulfur cluster binding
TherJR_0769	COG3383	formate dehydrogenase (NAD+) activity
TherJR_0769	COG0243	molybdopterin cofactor binding
TherJR_0771	COG0437	4 iron, 4 sulfur cluster binding
TherJR_0772	COG3301	Polysulphide reductase, NrfD
TherJR_0774	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TherJR_0775	COG0459	protein refolding
TherJR_0781	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TherJR_0783	COG0714	Associated with various cellular activities
TherJR_0785	COG1305	Transglutaminase-like
TherJR_0787	COG0519	Catalyzes the synthesis of GMP from XMP
TherJR_0787	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TherJR_0789	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TherJR_0794	COG3842	ATPase activity
TherJR_0797	COG4191	Histidine kinase
TherJR_0799	COG0444	Belongs to the ABC transporter superfamily
TherJR_0800	COG4608	Belongs to the ABC transporter superfamily
TherJR_0801	COG0747	negative chemotaxis
TherJR_0813	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
TherJR_0819	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TherJR_0821	COG0583	DNA-binding transcription factor activity
TherJR_0822	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TherJR_0823	COG2252	PERMEase
TherJR_0824	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TherJR_0825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TherJR_0826	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TherJR_0827	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TherJR_0828	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TherJR_0829	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TherJR_0830	COG0138	bifunctional purine biosynthesis protein purh
TherJR_0831	COG0151	Belongs to the GarS family
TherJR_0832	COG4496	protein, YerC YecD
TherJR_0833	COG3290	protein histidine kinase activity
TherJR_0834	COG0124	histidyl-tRNA synthetase
TherJR_0837	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TherJR_0838	COG0131	Imidazoleglycerol-phosphate dehydratase
TherJR_0840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TherJR_0841	COG0107	imidazoleglycerol-phosphate synthase activity
TherJR_0842	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TherJR_0842	COG0140	phosphoribosyl-ATP diphosphatase activity
TherJR_0843	COG0840	transmembrane signaling receptor activity
TherJR_0843	COG3290	protein histidine kinase activity
TherJR_0845	COG0730	response to heat
TherJR_0848	COG0210	DNA helicase
TherJR_0850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TherJR_0851	COG1959	2 iron, 2 sulfur cluster binding
TherJR_0852	COG1271	oxidase subunit
TherJR_0853	COG1294	oxidase, subunit
TherJR_0854	COG1773	rubredoxin
TherJR_0854	COG1592	Rubrerythrin
TherJR_0857	COG1404	Belongs to the peptidase S8 family
TherJR_0858	COG1924	4 iron, 4 sulfur cluster binding
TherJR_0859	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TherJR_0861	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TherJR_0862	COG0765	amino acid transport
TherJR_0870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TherJR_0871	COG0154	amidase activity
TherJR_0872	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TherJR_0874	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TherJR_0875	COG0538	isocitrate dehydrogenase activity
TherJR_0876	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TherJR_0884	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TherJR_0885	COG1543	Belongs to the glycosyl hydrolase 57 family
TherJR_0890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TherJR_0897	COG0464	growth
TherJR_0898	COG1404	Belongs to the peptidase S8 family
TherJR_0899	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TherJR_0900	COG0732	type I restriction modification DNA specificity domain
TherJR_0901	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TherJR_0908	COG0058	SHG alpha-glucan phosphorylase activity
TherJR_0909	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TherJR_0910	COG0071	Belongs to the small heat shock protein (HSP20) family
TherJR_0911	COG0589	response to stress
TherJR_0913	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TherJR_0913	COG0519	Catalyzes the synthesis of GMP from XMP
TherJR_0916	COG1566	PFAM secretion protein HlyD family protein
TherJR_0917	COG2814	Major facilitator Superfamily
TherJR_0918	COG1846	Transcriptional regulator
TherJR_0923	COG1136	(ABC) transporter
TherJR_0924	COG0719	Fe-S assembly protein
TherJR_0925	COG0443	Heat shock 70 kDa protein
TherJR_0928	COG0542	response to heat
TherJR_0929	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TherJR_0931	COG0446	pyridine nucleotide-disulphide oxidoreductase
TherJR_0932	COG1309	transcriptional regulator
TherJR_0934	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TherJR_0937	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TherJR_0942	COG3383	formate dehydrogenase (NAD+) activity
TherJR_0943	COG0583	DNA-binding transcription factor activity
TherJR_0947	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TherJR_0948	COG2132	Multicopper oxidase
TherJR_0949	COG0288	reversible hydration of carbon dioxide
TherJR_0950	COG1595	DNA-templated transcription, initiation
TherJR_0954	COG0463	Glycosyl transferase, family 2
TherJR_0954	COG0457	Tetratricopeptide repeat
TherJR_0955	COG0457	Tetratricopeptide repeat
TherJR_0955	COG0463	Glycosyl transferase, family 2
TherJR_0956	COG0463	Glycosyl transferase, family 2
TherJR_0956	COG0457	Tetratricopeptide repeat
TherJR_0960	COG0463	Glycosyl transferase, family 2
TherJR_0960	COG0457	Tetratricopeptide repeat
TherJR_0964	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TherJR_0965	COG1971	Probably functions as a manganese efflux pump
TherJR_0966	COG0237	dephospho-CoA kinase activity
TherJR_0967	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TherJR_0968	COG4166	transmembrane transport
TherJR_0969	COG0601	transmembrane transport
TherJR_0971	COG0444	Belongs to the ABC transporter superfamily
TherJR_0972	COG4608	Belongs to the ABC transporter superfamily
TherJR_0983	COG5012	cobalamin binding
TherJR_0984	COG5012	cobalamin binding
TherJR_0986	COG1410	methionine synthase
TherJR_0986	COG0646	methionine synthase
TherJR_0989	COG0523	cobalamin synthesis protein
TherJR_0991	COG0069	glutamate synthase activity
TherJR_0991	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TherJR_1002	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TherJR_1003	COG1116	anion transmembrane transporter activity
TherJR_1005	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
TherJR_1006	COG1074	ATP-dependent DNA helicase activity
TherJR_1014	COG2949	membrane
TherJR_1027	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TherJR_1036	COG0587	DNA-directed DNA polymerase activity
TherJR_1040	COG0574	Belongs to the PEP-utilizing enzyme family
TherJR_1040	COG3848	Pyruvate phosphate dikinase
TherJR_1043	COG3005	denitrification pathway
TherJR_1046	COG2199	diguanylate cyclase activity
TherJR_1046	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TherJR_1050	COG1376	ErfK ybiS ycfS ynhG family protein
TherJR_1057	COG0010	Belongs to the arginase family
TherJR_1059	COG1191	sigma factor activity
TherJR_1065	COG1205	dead DEAH box helicase
TherJR_1065	COG1111	helicase
TherJR_1066	COG1111	helicase
TherJR_1066	COG1205	dead DEAH box helicase
TherJR_1070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TherJR_1080	COG1196	nuclear chromosome segregation
TherJR_1084	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TherJR_1090	COG0778	Nitroreductase
TherJR_1091	COG2860	membrane
TherJR_1092	COG1191	sigma factor activity
TherJR_1093	COG0444	Belongs to the ABC transporter superfamily
TherJR_1094	COG4608	Belongs to the ABC transporter superfamily
TherJR_1095	COG0747	negative chemotaxis
TherJR_1097	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TherJR_1101	COG0189	ligase activity
TherJR_1102	COG0189	ligase activity
TherJR_1103	COG0189	ligase activity
TherJR_1104	COG0189	ligase activity
TherJR_1108	COG1129	ABC transporter
TherJR_1108	COG0842	Transport permease protein
TherJR_1111	COG1012	belongs to the aldehyde dehydrogenase family
TherJR_1111	COG1454	alcohol dehydrogenase
TherJR_1115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TherJR_1118	COG3005	denitrification pathway
TherJR_1126	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TherJR_1127	COG1032	radical SAM domain protein
TherJR_1131	COG1333	cytochrome c biogenesis protein
TherJR_1132	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TherJR_1133	COG1648	precorrin-2 dehydrogenase activity
TherJR_1133	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TherJR_1134	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TherJR_1135	COG0181	hydroxymethylbilane synthase activity
TherJR_1138	COG0113	porphobilinogen synthase activity
TherJR_1142	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TherJR_1144	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TherJR_1145	COG0849	cell division
TherJR_1153	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TherJR_1153	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TherJR_1171	COG0586	Pfam SNARE associated Golgi protein
TherJR_1176	COG1181	Belongs to the D-alanine--D-alanine ligase family
TherJR_1177	COG0217	transcriptional regulatory protein
TherJR_1180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TherJR_1183	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TherJR_1185	COG1191	sigma factor activity
TherJR_1187	COG2385	sporulation resulting in formation of a cellular spore
TherJR_1189	COG0697	spore germination
TherJR_1190	COG0697	spore germination
TherJR_1192	COG0765	amino acid transport
TherJR_1194	COG4869	propanediol catabolic process
TherJR_1196	COG0745	RESPONSE REGULATOR receiver
TherJR_1198	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
TherJR_1200	COG0343	queuine tRNA-ribosyltransferase activity
TherJR_1203	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TherJR_1204	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TherJR_1205	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TherJR_1205	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TherJR_1206	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TherJR_1207	COG1490	D-aminoacyl-tRNA deacylase activity
TherJR_1208	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TherJR_1211	COG0613	PHP domain protein
TherJR_1212	COG0569	domain protein
TherJR_1216	COG1388	LysM domain
TherJR_1220	COG0745	RESPONSE REGULATOR receiver
TherJR_1221	COG5002	protein histidine kinase activity
TherJR_1222	COG2181	nitrate reductase activity
TherJR_1222	COG0247	lactate metabolic process
TherJR_1232	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TherJR_1233	COG0444	Belongs to the ABC transporter superfamily
TherJR_1234	COG4608	Belongs to the ABC transporter superfamily
TherJR_1235	COG2226	methyltransferase
TherJR_1241	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TherJR_1242	COG4172	Belongs to the ABC transporter superfamily
TherJR_1243	COG0500	methyltransferase
TherJR_1246	COG0446	pyridine nucleotide-disulphide oxidoreductase
TherJR_1255	COG3693	PFAM glycoside hydrolase, family 10
TherJR_1262	COG0310	cobalt ion transport
TherJR_1264	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TherJR_1265	COG1122	ATPase activity
TherJR_1268	COG2249	NAD(P)H dehydrogenase (quinone) activity
TherJR_1270	COG0446	pyridine nucleotide-disulphide oxidoreductase
TherJR_1274	COG0598	Magnesium transport protein CorA
TherJR_1277	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TherJR_1278	COG2137	regulation of response to DNA damage stimulus
TherJR_1279	COG1418	mRNA catabolic process
TherJR_1281	COG1692	metallophosphoesterase
TherJR_1282	COG2359	stage V sporulation protein S
TherJR_1284	COG0436	Aminotransferase
TherJR_1286	COG3103	Sh3 type 3 domain protein
TherJR_1286	COG0791	NLP P60 protein
TherJR_1286	COG1388	LysM domain
TherJR_1287	COG1525	nuclease
TherJR_1288	COG1113	amino acid transport
TherJR_1291	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TherJR_1298	COG1136	(ABC) transporter
TherJR_1298	COG0577	efflux transmembrane transporter activity
TherJR_1299	COG1136	(ABC) transporter
TherJR_1300	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TherJR_1301	COG0298	carbon dioxide binding
TherJR_1302	COG0409	Hydrogenase expression formation protein
TherJR_1308	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TherJR_1312	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TherJR_1313	COG0406	alpha-ribazole phosphatase activity
TherJR_1315	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TherJR_1319	COG0516	GMP reductase activity
TherJR_1319	COG0517	IMP dehydrogenase activity
TherJR_1321	COG0542	response to heat
TherJR_1326	COG0735	belongs to the Fur family
TherJR_1329	COG0730	response to heat
TherJR_1330	COG0730	response to heat
TherJR_1334	COG0772	Belongs to the SEDS family
TherJR_1336	COG0494	nUDIX hydrolase
TherJR_1342	COG0850	regulation of cytokinetic process
TherJR_1343	COG2203	Gaf domain
TherJR_1343	COG2199	diguanylate cyclase activity
TherJR_1349	COG5002	protein histidine kinase activity
TherJR_1351	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TherJR_1353	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
TherJR_1355	COG2707	UPF0756 membrane protein
TherJR_1356	COG0052	Belongs to the universal ribosomal protein uS2 family
TherJR_1357	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TherJR_1358	COG0528	UMP kinase activity
TherJR_1359	COG0233	cytoplasmic translational termination
TherJR_1363	COG4589	Belongs to the CDS family
TherJR_1364	COG0628	permease
TherJR_1365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TherJR_1366	COG0750	zinc metalloprotease
TherJR_1367	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TherJR_1368	COG0442	prolyl-tRNA aminoacylation
TherJR_1370	COG1285	pathogenesis
TherJR_1373	COG0779	Required for maturation of 30S ribosomal subunits
TherJR_1374	COG0195	Participates in both transcription termination and antitermination
TherJR_1375	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TherJR_1377	COG3064	Membrane
TherJR_1377	COG3064	Membrane
TherJR_1377	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TherJR_1377	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TherJR_1378	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TherJR_1379	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TherJR_1380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TherJR_1381	COG0196	riboflavin kinase activity
TherJR_1384	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TherJR_1385	COG1185	polyribonucleotide nucleotidyltransferase activity
TherJR_1386	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TherJR_1387	COG3409	Peptidoglycan-binding domain 1 protein
TherJR_1387	COG3773	Cell wall hydrolase
TherJR_1388	COG1388	LysM domain
TherJR_1388	COG0791	NLP P60 protein
TherJR_1389	COG1388	LysM domain
TherJR_1389	COG3858	chitin binding
TherJR_1390	COG0726	polysaccharide deacetylase
TherJR_1391	COG1686	Belongs to the peptidase S11 family
TherJR_1392	COG0612	Peptidase, M16
TherJR_1393	COG0756	dUTP diphosphatase activity
TherJR_1396	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TherJR_1397	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TherJR_1398	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TherJR_1399	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TherJR_1400	COG0527	aspartate kinase activity
TherJR_1401	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TherJR_1402	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TherJR_1403	COG0740	serine-type endopeptidase activity
TherJR_1405	COG1968	undecaprenyl-diphosphatase activity
TherJR_1406	COG1674	ftsk spoiiie
TherJR_1407	COG1744	ABC transporter substrate-binding protein PnrA-like
TherJR_1411	COG0463	Glycosyl transferase, family 2
TherJR_1412	COG1368	sulfuric ester hydrolase activity
TherJR_1414	COG3949	Membrane
TherJR_1417	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TherJR_1418	COG1426	Protein conserved in bacteria
TherJR_1427	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TherJR_1429	COG1666	GTP binding
TherJR_1433	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TherJR_1434	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TherJR_1436	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TherJR_1437	COG1546	Belongs to the CinA family
TherJR_1437	COG1058	Belongs to the CinA family
TherJR_1439	COG0513	Belongs to the DEAD box helicase family
TherJR_1442	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TherJR_1443	COG0352	thiamine-phosphate diphosphorylase activity
TherJR_1446	COG1131	(ABC) transporter
TherJR_1448	COG1307	EDD domain protein, DegV family
TherJR_1449	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TherJR_1461	COG0517	IMP dehydrogenase activity
TherJR_1462	COG4974	Belongs to the 'phage' integrase family
TherJR_1467	COG3328	transposase activity
TherJR_1469	COG2045	Belongs to the ComB family
TherJR_1470	COG1809	phosphosulfolactate synthase activity
TherJR_1471	COG2046	Belongs to the sulfate adenylyltransferase family
TherJR_1472	COG1116	anion transmembrane transporter activity
TherJR_1474	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TherJR_1478	COG2814	Major facilitator Superfamily
TherJR_1485	COG2323	membrane
TherJR_1487	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TherJR_1488	COG3679	Belongs to the UPF0342 family
TherJR_1489	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TherJR_1492	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TherJR_1493	COG2136	Putative SAM-dependent methyltransferase
TherJR_1493	COG2521	methyltransferase
TherJR_1494	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TherJR_1495	COG1923	regulation of RNA biosynthetic process
TherJR_1497	COG0464	growth
TherJR_1498	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TherJR_1505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TherJR_1505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TherJR_1506	COG0281	malic enzyme
TherJR_1512	COG1191	sigma factor activity
TherJR_1514	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TherJR_1515	COG1776	CheC inhibitor of MCP methylation
TherJR_1517	COG2198	Histidine kinase
TherJR_1517	COG0643	Histidine kinase
TherJR_1518	COG2201	protein-glutamate methylesterase activity
TherJR_1520	COG0455	bacterial-type flagellum organization
TherJR_1521	COG1419	protein localization to endoplasmic reticulum
TherJR_1522	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TherJR_1523	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TherJR_1524	COG1684	flagellar biosynthetic protein fliR
TherJR_1525	COG1987	bacterial-type flagellum assembly
TherJR_1526	COG1338	Plays a role in the flagellum-specific transport system
TherJR_1528	COG2201	protein-glutamate methylesterase activity
TherJR_1529	COG1776	CheC inhibitor of MCP methylation
TherJR_1529	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TherJR_1530	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TherJR_1532	COG1582	Flagellar protein (FlbD)
TherJR_1535	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TherJR_1539	COG1157	protein secretion by the type III secretion system
TherJR_1541	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TherJR_1542	COG1766	The M ring may be actively involved in energy transduction
TherJR_1543	COG1677	Flagellar hook-basal body complex protein FliE
TherJR_1547	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TherJR_1548	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TherJR_1549	COG4974	Belongs to the 'phage' integrase family
TherJR_1550	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TherJR_1551	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TherJR_1552	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TherJR_1552	COG0758	DNA mediated transformation
TherJR_1553	COG3285	dna ligase
TherJR_1553	COG1793	dna ligase
TherJR_1554	COG1793	dna ligase
TherJR_1555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TherJR_1559	COG3773	Cell wall hydrolase
TherJR_1561	COG0561	phosphatase activity
TherJR_1567	COG2875	Belongs to the precorrin methyltransferase family
TherJR_1571	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TherJR_1576	COG0860	N-Acetylmuramoyl-L-alanine amidase
TherJR_1579	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TherJR_1580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TherJR_1581	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TherJR_1583	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TherJR_1590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TherJR_1590	COG0539	negative regulation of cytoplasmic translation
TherJR_1591	COG0204	Acyl-transferase
TherJR_1592	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TherJR_1595	COG0840	transmembrane signaling receptor activity
TherJR_1596	COG0835	chemotaxis
TherJR_1597	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TherJR_1598	COG0287	Prephenate dehydrogenase
TherJR_1599	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TherJR_1600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TherJR_1602	COG0133	tryptophan synthase activity
TherJR_1603	COG0135	phosphoribosylanthranilate isomerase activity
TherJR_1604	COG0134	indole-3-glycerol-phosphate synthase activity
TherJR_1605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TherJR_1606	COG0512	Glutamine amidotransferase of anthranilate synthase
TherJR_1611	COG2081	HI0933 family
TherJR_1612	COG1346	cytolysis
TherJR_1613	COG1380	Effector of murein hydrolase LrgA
TherJR_1615	COG1279	arginine transmembrane transporter activity
TherJR_1623	COG1418	mRNA catabolic process
TherJR_1627	COG1187	pseudouridine synthase activity
TherJR_1628	COG0700	Nucleoside recognition
TherJR_1629	COG2715	membrane protein required for spore maturation
TherJR_1630	COG0445	tRNA wobble uridine modification
TherJR_1631	COG3874	Sporulation protein YtfJ
TherJR_1634	COG0437	4 iron, 4 sulfur cluster binding
TherJR_1636	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TherJR_1638	COG0180	Tryptophanyl-tRNA synthetase
TherJR_1639	COG1994	Peptidase M50
TherJR_1640	COG0617	tRNA 3'-terminal CCA addition
TherJR_1641	COG0019	diaminopimelate decarboxylase activity
TherJR_1642	COG0393	Putative heavy-metal-binding
TherJR_1643	COG2340	Cysteine-rich secretory protein family
TherJR_1644	COG2076	Multidrug Resistance protein
TherJR_1645	COG0494	nUDIX hydrolase
TherJR_1647	COG1924	4 iron, 4 sulfur cluster binding
TherJR_1650	COG0697	spore germination
TherJR_1653	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TherJR_1656	COG1191	sigma factor activity
TherJR_1657	COG2172	sigma factor antagonist activity
TherJR_1659	COG1686	Belongs to the peptidase S11 family
TherJR_1660	COG0531	amino acid
TherJR_1664	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TherJR_1665	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TherJR_1666	COG4974	Belongs to the 'phage' integrase family
TherJR_1670	COG1379	DNA repair
TherJR_1673	COG2195	Cleaves the N-terminal amino acid of tripeptides
TherJR_1681	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TherJR_1683	COG0280	phosphate acetyltransferase
TherJR_1684	COG3290	protein histidine kinase activity
TherJR_1684	COG3829	transcription factor binding
TherJR_1689	COG0745	RESPONSE REGULATOR receiver
TherJR_1690	COG0750	zinc metalloprotease
TherJR_1691	COG0497	DNA recombination
TherJR_1693	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TherJR_1694	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TherJR_1698	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TherJR_1699	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TherJR_1701	COG0142	geranyltranstransferase activity
TherJR_1702	COG1722	exodeoxyribonuclease VII activity
TherJR_1706	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TherJR_1707	COG0493	'glutamate synthase
TherJR_1710	COG1388	LysM domain
TherJR_1712	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TherJR_1714	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TherJR_1715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TherJR_1718	COG1302	Protein conserved in bacteria
TherJR_1719	COG0439	Biotin carboxylase
TherJR_1728	COG3854	ATPases associated with a variety of cellular activities
TherJR_1731	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TherJR_1732	COG0006	proline dipeptidase activity
TherJR_1733	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TherJR_1734	COG0312	modulator of DNA gyrase
TherJR_1738	COG0328	RNA-DNA hybrid ribonuclease activity
TherJR_1739	COG0312	modulator of DNA gyrase
TherJR_1740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TherJR_1741	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TherJR_1742	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TherJR_1749	COG4970	Tfp pilus assembly protein FimT
TherJR_1750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TherJR_1751	COG2165	general secretion pathway protein
TherJR_1754	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TherJR_1756	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TherJR_1758	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TherJR_1759	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TherJR_1762	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TherJR_1765	COG3706	GGDEF domain
TherJR_1765	COG0745	RESPONSE REGULATOR receiver
TherJR_1766	COG0425	Belongs to the sulfur carrier protein TusA family
TherJR_1768	COG0805	protein transport
TherJR_1769	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TherJR_1770	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TherJR_1771	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TherJR_1772	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TherJR_1773	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TherJR_1774	COG2226	methyltransferase
TherJR_1778	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TherJR_1780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TherJR_1781	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TherJR_1781	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TherJR_1783	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TherJR_1783	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TherJR_1784	COG2155	Conserved Protein
TherJR_1785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TherJR_1786	COG1162	GTPase activity
TherJR_1787	COG0515	serine threonine protein kinase
TherJR_1787	COG2815	serine threonine protein kinase
TherJR_1788	COG0768	penicillin binding
TherJR_1790	COG0631	protein serine/threonine phosphatase activity
TherJR_1793	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TherJR_1794	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TherJR_1794	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TherJR_1795	COG2738	Putative neutral zinc metallopeptidase
TherJR_1796	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TherJR_1797	COG0242	peptide deformylase activity
TherJR_1798	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TherJR_1802	COG1309	transcriptional regulator
TherJR_1807	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TherJR_1809	COG0194	GDP metabolic process
TherJR_1810	COG2052	Domain of unknown function (DUF370)
TherJR_1811	COG1561	YicC-like family, N-terminal region
TherJR_1813	COG0436	Aminotransferase
TherJR_1814	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TherJR_1816	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TherJR_1819	COG0437	4 iron, 4 sulfur cluster binding
TherJR_1822	COG0840	transmembrane signaling receptor activity
TherJR_1822	COG3290	protein histidine kinase activity
TherJR_1824	COG1683	Conserved Protein
TherJR_1826	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TherJR_1827	COG0284	orotidine-5'-phosphate decarboxylase activity
TherJR_1828	COG0167	dihydroorotate dehydrogenase activity
TherJR_1829	COG0543	2 iron, 2 sulfur cluster binding
TherJR_1830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TherJR_1831	COG0505	Belongs to the CarA family
TherJR_1832	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TherJR_1833	COG0540	Belongs to the ATCase OTCase family
TherJR_1834	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TherJR_1837	COG0564	pseudouridine synthase activity
TherJR_1838	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TherJR_1839	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TherJR_1840	COG0778	Nitroreductase
TherJR_1847	COG3005	denitrification pathway
TherJR_1848	COG2197	response regulator
TherJR_1850	COG2848	UPF0210 protein
TherJR_1851	COG3830	Belongs to the UPF0237 family
TherJR_1853	COG0456	acetyltransferase
TherJR_1856	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TherJR_1858	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TherJR_1860	COG1872	DUF167
TherJR_1861	COG3599	regulation of cell shape
TherJR_1862	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TherJR_1863	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TherJR_1865	COG1193	negative regulation of DNA recombination
TherJR_1868	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TherJR_1868	COG1796	DNA polymerase
TherJR_1869	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TherJR_1870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TherJR_1870	COG0072	phenylalanine-tRNA ligase activity
TherJR_1871	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TherJR_1872	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TherJR_1873	COG0569	domain protein
TherJR_1874	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TherJR_1875	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TherJR_1876	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TherJR_1877	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TherJR_1878	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TherJR_1879	COG4399	Belongs to the UPF0754 family
TherJR_1885	COG1518	maintenance of DNA repeat elements
TherJR_1891	COG0768	penicillin binding
TherJR_1896	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TherJR_1898	COG2720	vancomycin resistance protein
TherJR_1899	COG3906	Belongs to the UPF0473 family
TherJR_1900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TherJR_1901	COG0667	Aldo Keto reductase
TherJR_1904	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TherJR_1906	COG0628	permease
TherJR_1912	COG0822	iron-sulfur transferase activity
TherJR_1914	COG1959	2 iron, 2 sulfur cluster binding
TherJR_1917	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TherJR_1919	COG0735	belongs to the Fur family
TherJR_1921	COG1937	Protein conserved in bacteria
TherJR_1922	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TherJR_1923	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TherJR_1924	COG0124	histidyl-tRNA synthetase
TherJR_1926	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TherJR_1927	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TherJR_1928	COG2244	polysaccharide biosynthetic process
TherJR_1929	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TherJR_1931	COG0302	gtp cyclohydrolase
TherJR_1934	COG3706	GGDEF domain
TherJR_1936	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TherJR_1937	COG1151	hydroxylamine reductase activity
TherJR_1941	COG0842	Transport permease protein
TherJR_1942	COG1131	(ABC) transporter
TherJR_1947	COG3852	Histidine kinase
TherJR_1957	COG1183	phosphatidylcholine synthase activity
TherJR_1958	COG0688	phosphatidylethanolamine metabolic process
TherJR_1959	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TherJR_1959	COG1199	ATP-dependent helicase activity
TherJR_1960	COG0432	Pfam Uncharacterised protein family UPF0047
TherJR_1962	COG0492	ferredoxin-NADP+ reductase activity
TherJR_1965	COG1694	Mazg nucleotide pyrophosphohydrolase
TherJR_1970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TherJR_1974	COG0582	viral genome integration into host DNA
TherJR_1976	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TherJR_1977	COG2815	serine threonine protein kinase
TherJR_1977	COG0515	serine threonine protein kinase
TherJR_1985	COG0563	adenylate kinase activity
TherJR_1986	COG1773	rubredoxin
TherJR_1986	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TherJR_1989	COG0420	3'-5' exonuclease activity
TherJR_1990	COG2719	SpoVR family
TherJR_1991	COG2718	Belongs to the UPF0229 family
TherJR_1992	COG2766	serine protein kinase
TherJR_1999	COG3328	transposase activity
TherJR_2010	COG3481	metal-dependent phosphohydrolase, HD sub domain
TherJR_2014	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TherJR_2019	COG1567	CRISPR-associated RAMP protein, Csm4 family
TherJR_2020	COG1337	RAMP superfamily
TherJR_2022	COG1353	crispr-associated protein
TherJR_2024	COG3829	transcription factor binding
TherJR_2024	COG3290	protein histidine kinase activity
TherJR_2026	COG0606	chelatase, subunit chli
TherJR_2027	COG0792	nuclease activity
TherJR_2028	COG1007	ATP synthesis coupled electron transport
TherJR_2029	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TherJR_2030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TherJR_2033	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TherJR_2034	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TherJR_2035	COG0649	NAD binding
TherJR_2036	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TherJR_2037	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TherJR_2038	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TherJR_2041	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TherJR_2042	COG0681	Belongs to the peptidase S26 family
TherJR_2043	COG0335	large ribosomal subunit rRNA binding
TherJR_2045	COG4752	Belongs to the RNA methyltransferase TrmD family
TherJR_2046	COG0336	Belongs to the RNA methyltransferase TrmD family
TherJR_2047	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TherJR_2049	COG1837	Belongs to the UPF0109 family
TherJR_2050	COG0228	four-way junction DNA binding
TherJR_2051	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TherJR_2054	COG0306	phosphate transporter
TherJR_2056	COG0402	S-adenosylhomocysteine deaminase activity
TherJR_2058	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TherJR_2059	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TherJR_2060	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TherJR_2061	COG0552	protein localization to endoplasmic reticulum
TherJR_2063	COG1196	nuclear chromosome segregation
TherJR_2064	COG3706	GGDEF domain
TherJR_2065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TherJR_2068	COG2226	methyltransferase
TherJR_2070	COG0571	ribonuclease III activity
TherJR_2071	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TherJR_2073	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TherJR_2074	COG1028	Short-chain dehydrogenase reductase Sdr
TherJR_2075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TherJR_2077	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TherJR_2078	COG0416	fatty acid biosynthetic process
TherJR_2079	COG2030	dehydratase
TherJR_2080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TherJR_2081	COG1399	metal-binding, possibly nucleic acid-binding protein
TherJR_2082	COG0280	phosphate acetyltransferase
TherJR_2084	COG3314	Sporulation integral membrane protein YlbJ
TherJR_2086	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TherJR_2087	COG0742	ribosomal rna small subunit methyltransferase
TherJR_2089	COG0438	transferase activity, transferring glycosyl groups
TherJR_2090	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TherJR_2092	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TherJR_2093	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TherJR_2099	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TherJR_2100	COG1307	EDD domain protein, DegV family
TherJR_2101	COG1461	Dihydroxyacetone kinase
TherJR_2102	COG1302	Protein conserved in bacteria
TherJR_2104	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TherJR_2105	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TherJR_2106	COG0622	Phosphoesterase
TherJR_2109	COG1376	ErfK ybiS ycfS ynhG family protein
TherJR_2111	COG1639	'signal transduction protein
TherJR_2112	COG3437	response regulator, receiver
TherJR_2112	COG0784	Response regulator, receiver
TherJR_2113	COG0083	homoserine kinase activity
TherJR_2114	COG0460	homoserine dehydrogenase
TherJR_2115	COG4492	Belongs to the UPF0735 family
TherJR_2120	COG2302	S4 RNA-binding domain
TherJR_2122	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TherJR_2123	COG1799	cell septum assembly
TherJR_2124	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TherJR_2126	COG0704	Plays a role in the regulation of phosphate uptake
TherJR_2127	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TherJR_2128	COG5002	protein histidine kinase activity
TherJR_2129	COG0745	RESPONSE REGULATOR receiver
TherJR_2131	COG3773	Cell wall hydrolase
TherJR_2131	COG3409	Peptidoglycan-binding domain 1 protein
TherJR_2137	COG3773	Cell wall hydrolase
TherJR_2137	COG3409	Peptidoglycan-binding domain 1 protein
TherJR_2139	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TherJR_2142	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TherJR_2145	COG1873	PFAM PRC-barrel domain
TherJR_2148	COG1191	sigma factor activity
TherJR_2149	COG1191	sigma factor activity
TherJR_2152	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TherJR_2154	COG3856	small basic protein
TherJR_2156	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TherJR_2157	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TherJR_2158	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TherJR_2159	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TherJR_2160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TherJR_2161	COG0772	Belongs to the SEDS family
TherJR_2162	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TherJR_2163	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TherJR_2164	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TherJR_2165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TherJR_2166	COG0768	penicillin binding
TherJR_2168	COG0275	rRNA processing
TherJR_2169	COG2001	Belongs to the MraZ family
TherJR_2172	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TherJR_2178	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TherJR_2179	COG1489	DNA binding
TherJR_2183	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TherJR_2188	COG0288	reversible hydration of carbon dioxide
TherJR_2189	COG1136	(ABC) transporter
TherJR_2189	COG0577	efflux transmembrane transporter activity
TherJR_2190	COG1136	(ABC) transporter
TherJR_2191	COG0577	efflux transmembrane transporter activity
TherJR_2191	COG1136	(ABC) transporter
TherJR_2194	COG0501	Belongs to the peptidase M48B family
TherJR_2196	COG1283	sodium-dependent phosphate transmembrane transporter activity
TherJR_2197	COG3290	protein histidine kinase activity
TherJR_2197	COG0840	transmembrane signaling receptor activity
TherJR_2200	COG1686	Belongs to the peptidase S11 family
TherJR_2202	COG1533	DNA photolyase activity
TherJR_2206	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TherJR_2209	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TherJR_2224	COG3949	Membrane
TherJR_2225	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TherJR_2229	COG0303	'Molybdopterin
TherJR_2230	COG1058	Belongs to the CinA family
TherJR_2230	COG1546	Belongs to the CinA family
TherJR_2231	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TherJR_2232	COG4149	molybdate abc transporter
TherJR_2233	COG0725	ABC transporter, periplasmic molybdate-binding protein
TherJR_2235	COG3383	formate dehydrogenase (NAD+) activity
TherJR_2241	COG2217	Heavy metal translocating P-type atpase
TherJR_2242	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TherJR_2243	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TherJR_2245	COG0425	Belongs to the sulfur carrier protein TusA family
TherJR_2246	COG2221	Nitrite and sulphite reductase 4Fe-4S
TherJR_2247	COG2046	Belongs to the sulfate adenylyltransferase family
TherJR_2249	COG1053	succinate dehydrogenase
TherJR_2250	COG0529	Catalyzes the synthesis of activated sulfate
TherJR_2251	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TherJR_2253	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TherJR_2254	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TherJR_2255	COG0800	Aldolase
TherJR_2257	COG3842	ATPase activity
TherJR_2258	COG4948	Mandelate Racemase Muconate Lactonizing
TherJR_2261	COG0395	ABC-type sugar transport system, permease component
TherJR_2263	COG1653	transport
TherJR_2264	COG2414	aldehyde ferredoxin oxidoreductase
TherJR_2265	COG1414	Transcriptional regulator
TherJR_2268	COG2011	ABC-type metal ion transport system permease component
TherJR_2269	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TherJR_2276	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TherJR_2278	COG4555	ABC transporter
TherJR_2282	COG1138	Cytochrome C-type biogenesis protein
TherJR_2288	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TherJR_2291	COG1937	Protein conserved in bacteria
TherJR_2297	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TherJR_2298	COG2384	SAM-dependent methyltransferase
TherJR_2302	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TherJR_2303	COG0358	DNA primase activity
TherJR_2304	COG1671	Belongs to the UPF0178 family
TherJR_2305	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TherJR_2307	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TherJR_2308	COG1122	ATPase activity
TherJR_2311	COG0581	inorganic phosphate transmembrane transporter activity
TherJR_2312	COG0573	inorganic phosphate transmembrane transporter activity
TherJR_2313	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TherJR_2315	COG0745	RESPONSE REGULATOR receiver
TherJR_2316	COG0517	IMP dehydrogenase activity
TherJR_2316	COG0516	GMP reductase activity
TherJR_2321	COG0546	phosphoglycolate phosphatase activity
TherJR_2323	COG5001	Diguanylate cyclase
TherJR_2323	COG3300	MHYT domain
TherJR_2326	COG0205	6-phosphofructokinase activity
TherJR_2327	COG0825	malonyl-CoA metabolic process
TherJR_2328	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TherJR_2333	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TherJR_2336	COG0011	TIGRFAM Protein of
TherJR_2337	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TherJR_2338	COG0735	belongs to the Fur family
TherJR_2339	COG0438	transferase activity, transferring glycosyl groups
TherJR_2340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TherJR_2342	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TherJR_2343	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TherJR_2344	COG1763	Mo-molybdopterin cofactor biosynthetic process
TherJR_2345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TherJR_2347	COG0726	polysaccharide deacetylase
TherJR_2348	COG2226	methyltransferase
TherJR_2350	COG0517	IMP dehydrogenase activity
TherJR_2355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TherJR_2357	COG2720	vancomycin resistance protein
TherJR_2362	COG0297	glycogen (starch) synthase activity
TherJR_2367	COG0297	glycogen (starch) synthase activity
TherJR_2368	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TherJR_2372	COG4224	UPF0291 protein
TherJR_2378	COG1752	Esterase of the alpha-beta hydrolase superfamily
TherJR_2383	COG0745	RESPONSE REGULATOR receiver
TherJR_2384	COG2205	protein histidine kinase activity
TherJR_2386	COG0432	Pfam Uncharacterised protein family UPF0047
TherJR_2387	COG0436	Aminotransferase
TherJR_2388	COG0037	tRNA processing
TherJR_2393	COG3546	catalase activity
TherJR_2400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TherJR_2400	COG0574	Belongs to the PEP-utilizing enzyme family
TherJR_2401	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TherJR_2402	COG0517	IMP dehydrogenase activity
TherJR_2403	COG0751	glycine-tRNA ligase activity
TherJR_2404	COG0752	glycyl-tRNA synthetase alpha subunit
TherJR_2406	COG1381	Involved in DNA repair and RecF pathway recombination
TherJR_2408	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TherJR_2411	COG1250	3-hydroxyacyl-CoA dehydrogenase
TherJR_2415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TherJR_2417	COG2239	Acts as a magnesium transporter
TherJR_2418	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TherJR_2419	COG0295	cytidine deaminase activity
TherJR_2420	COG1470	cell adhesion involved in biofilm formation
TherJR_2421	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TherJR_2422	COG1480	7TM receptor with intracellular HD hydrolase
TherJR_2423	COG1702	phosphate starvation-inducible protein PhoH
TherJR_2427	COG4864	UPF0365 protein
TherJR_2428	COG1030	water channel activity
TherJR_2430	COG1704	LemA family
TherJR_2431	COG0631	protein serine/threonine phosphatase activity
TherJR_2442	COG0745	RESPONSE REGULATOR receiver
TherJR_2445	COG0537	adenosine 5'-monophosphoramidase activity
TherJR_2446	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TherJR_2447	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TherJR_2448	COG2264	protein methyltransferase activity
TherJR_2450	COG0443	Heat shock 70 kDa protein
TherJR_2453	COG1420	regulation of RNA biosynthetic process
TherJR_2454	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TherJR_2455	COG0481	GTPase activity
TherJR_2457	COG0728	peptidoglycan biosynthetic process
TherJR_2461	COG0268	Binds directly to 16S ribosomal RNA
TherJR_2462	COG1466	dna polymerase III delta subunit
TherJR_2463	COG2333	competence protein COMEC
TherJR_2463	COG0658	competence protein
TherJR_2464	COG1555	photosystem II stabilization
TherJR_2464	COG1596	polysaccharide export
TherJR_2465	COG0531	amino acid
TherJR_2467	COG1376	ErfK ybiS ycfS ynhG family protein
TherJR_2469	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TherJR_2482	COG1598	PFAM Uncharacterised protein family UPF0150
TherJR_2488	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TherJR_2489	COG1518	maintenance of DNA repeat elements
TherJR_2498	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TherJR_2503	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TherJR_2505	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TherJR_2509	COG0495	leucyl-tRNA aminoacylation
TherJR_2510	COG0318	PFAM AMP-dependent synthetase and ligase
TherJR_2511	COG2199	diguanylate cyclase activity
TherJR_2511	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TherJR_2512	COG0799	negative regulation of ribosome biogenesis
TherJR_2513	COG1713	HD superfamily hydrolase involved in NAD metabolism
TherJR_2514	COG0724	RNA recognition motif
TherJR_2515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TherJR_2517	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TherJR_2518	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TherJR_2519	COG1534	Rna-binding protein
TherJR_2521	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TherJR_2525	COG0697	spore germination
TherJR_2526	COG0697	spore germination
TherJR_2527	COG0531	amino acid
TherJR_2529	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TherJR_2531	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TherJR_2534	COG1530	ribonuclease E activity
TherJR_2537	COG1994	Peptidase M50
TherJR_2539	COG0772	Belongs to the SEDS family
TherJR_2540	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TherJR_2541	COG2894	cell division
TherJR_2542	COG0850	regulation of cytokinetic process
TherJR_2543	COG0768	penicillin binding
TherJR_2546	COG1077	Cell shape determining protein MreB Mrl
TherJR_2547	COG2003	Belongs to the UPF0758 family
TherJR_2548	COG0424	maF-like protein
TherJR_2553	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TherJR_2555	COG0285	dihydrofolate synthase activity
TherJR_2557	COG0525	valine-tRNA ligase activity
TherJR_2559	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TherJR_2560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TherJR_2561	COG1067	ATP-dependent peptidase activity
TherJR_2561	COG0470	DNA polymerase III
TherJR_2562	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TherJR_2563	COG0740	serine-type endopeptidase activity
TherJR_2564	COG0544	peptidyl-prolyl cis-trans isomerase activity
TherJR_2566	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TherJR_2567	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TherJR_2568	COG1234	tRNA 3'-trailer cleavage
TherJR_2569	COG1924	4 iron, 4 sulfur cluster binding
TherJR_2571	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TherJR_2572	COG2247	cell wall binding repeat
TherJR_2572	COG0860	N-Acetylmuramoyl-L-alanine amidase
TherJR_2574	COG4232	protein-disulfide reductase activity
TherJR_2588	COG3344	reverse transcriptase
TherJR_2591	COG3679	Belongs to the UPF0342 family
TherJR_2593	COG0613	PHP domain protein
TherJR_2603	COG1242	4 iron, 4 sulfur cluster binding
TherJR_2604	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TherJR_2607	COG0390	transport system, permease component
TherJR_2608	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TherJR_2610	COG0372	Belongs to the citrate synthase family
TherJR_2611	COG2207	Transcriptional regulator
TherJR_2612	COG2814	Major facilitator Superfamily
TherJR_2614	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TherJR_2615	COG2211	Major facilitator Superfamily
TherJR_2616	COG2211	Major facilitator Superfamily
TherJR_2619	COG5012	cobalamin binding
TherJR_2622	COG2188	Transcriptional regulator
TherJR_2623	COG5012	cobalamin binding
TherJR_2625	COG2271	Major facilitator Superfamily
TherJR_2628	COG5012	cobalamin binding
TherJR_2630	COG0840	transmembrane signaling receptor activity
TherJR_2632	COG1136	(ABC) transporter
TherJR_2632	COG0577	efflux transmembrane transporter activity
TherJR_2633	COG4591	ABC-type transport system involved in lipoprotein release permease component
TherJR_2633	COG1136	(ABC) transporter
TherJR_2634	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TherJR_2636	COG1131	(ABC) transporter
TherJR_2638	COG0745	RESPONSE REGULATOR receiver
TherJR_2639	COG5002	protein histidine kinase activity
TherJR_2640	COG5002	protein histidine kinase activity
TherJR_2641	COG0745	RESPONSE REGULATOR receiver
TherJR_2646	COG1733	regulation of RNA biosynthetic process
TherJR_2648	COG0778	Nitroreductase
TherJR_2650	COG2391	methyltransferase activity
TherJR_2660	COG3300	MHYT domain
TherJR_2660	COG5001	Diguanylate cyclase
TherJR_2666	COG0411	ABC transporter
TherJR_2668	COG0559	Belongs to the binding-protein-dependent transport system permease family
TherJR_2670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TherJR_2671	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TherJR_2672	COG0438	transferase activity, transferring glycosyl groups
TherJR_2677	COG0789	Transcriptional regulator
TherJR_2681	COG0477	Major facilitator Superfamily
TherJR_2683	COG5002	protein histidine kinase activity
TherJR_2684	COG0745	RESPONSE REGULATOR receiver
TherJR_2686	COG3842	ATPase activity
TherJR_2687	COG4120	Belongs to the binding-protein-dependent transport system permease family
TherJR_2690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TherJR_2691	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TherJR_2693	COG0557	exoribonuclease II activity
TherJR_2695	COG0318	PFAM AMP-dependent synthetase and ligase
TherJR_2696	COG0318	PFAM AMP-dependent synthetase and ligase
TherJR_2697	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TherJR_2700	COG1131	(ABC) transporter
TherJR_2701	COG1725	Transcriptional regulator
TherJR_2703	COG1131	(ABC) transporter
TherJR_2704	COG1725	Transcriptional regulator
TherJR_2706	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TherJR_2707	COG0148	phosphopyruvate hydratase activity
TherJR_2708	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TherJR_2709	COG0149	triose-phosphate isomerase activity
TherJR_2710	COG0126	phosphoglycerate kinase activity
TherJR_2713	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TherJR_2715	COG1481	regulation of sporulation
TherJR_2718	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TherJR_2719	COG1660	Displays ATPase and GTPase activities
TherJR_2721	COG1940	carbohydrate kinase activity
TherJR_2722	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TherJR_2723	COG2222	sugar isomerase
TherJR_2727	COG0561	phosphatase activity
TherJR_2728	COG1950	PFAM Membrane protein of
TherJR_2729	COG2119	membrane
TherJR_2731	COG0322	excinuclease ABC activity
TherJR_2732	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TherJR_2733	COG0556	nucleotide-excision repair
TherJR_2735	COG1573	uracil-dna glycosylase
TherJR_2738	COG3409	Peptidoglycan-binding domain 1 protein
TherJR_2738	COG0793	Belongs to the peptidase S41A family
TherJR_2739	COG4942	peptidase
TherJR_2740	COG2177	Part of the ABC transporter FtsEX involved in
TherJR_2741	COG2884	Cell division ATP-binding protein ftsE
TherJR_2748	COG1404	Belongs to the peptidase S8 family
TherJR_2752	COG1404	Belongs to the peptidase S8 family
TherJR_2760	COG3279	Response regulator of the LytR AlgR family
TherJR_2762	COG3290	protein histidine kinase activity
TherJR_2764	COG3958	Transketolase
TherJR_2765	COG3959	Transketolase, thiamine diphosphate binding domain
TherJR_2766	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TherJR_2770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TherJR_2771	COG0653	protein targeting
TherJR_2773	COG2199	diguanylate cyclase activity
TherJR_2773	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TherJR_2774	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TherJR_2774	COG2199	diguanylate cyclase activity
TherJR_2776	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TherJR_2777	COG1278	Cold shock
TherJR_2779	COG1516	flagellar protein fliS
TherJR_2780	COG2089	acid synthase
TherJR_2782	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TherJR_2783	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TherJR_2784	COG1083	cytidylyl-transferase
TherJR_2785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TherJR_2786	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TherJR_2791	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TherJR_2792	COG1334	flagellar protein FlaG
TherJR_2793	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TherJR_2795	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TherJR_2797	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TherJR_2798	COG4786	Flagellar basal body rod
TherJR_2798	COG1256	bacterial-type flagellum assembly
TherJR_2803	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
TherJR_2804	COG5001	Diguanylate cyclase
TherJR_2805	COG3706	GGDEF domain
TherJR_2805	COG0745	RESPONSE REGULATOR receiver
TherJR_2810	COG2197	response regulator
TherJR_2819	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TherJR_2820	COG2323	membrane
TherJR_2821	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TherJR_2822	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TherJR_2823	COG0728	peptidoglycan biosynthetic process
TherJR_2828	COG1316	TRANSCRIPTIONal
TherJR_2833	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TherJR_2839	COG0546	phosphoglycolate phosphatase activity
TherJR_2839	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TherJR_2842	COG0438	transferase activity, transferring glycosyl groups
TherJR_2847	COG0438	transferase activity, transferring glycosyl groups
TherJR_2850	COG1368	sulfuric ester hydrolase activity
TherJR_2851	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TherJR_2854	COG1137	ATPase activity
TherJR_2855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TherJR_2861	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TherJR_2863	COG4733	cellulase activity
TherJR_2863	COG5297	Belongs to the glycosyl hydrolase family 6
TherJR_2869	COG1408	metallophosphoesterase
TherJR_2870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TherJR_2871	COG2373	Large extracellular alpha-helical protein
TherJR_2882	COG4786	Flagellar basal body rod
TherJR_2884	COG1609	Transcriptional regulator
TherJR_2885	COG2385	sporulation resulting in formation of a cellular spore
TherJR_2886	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TherJR_2887	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TherJR_2888	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TherJR_2889	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TherJR_2890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TherJR_2891	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TherJR_2892	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TherJR_2893	COG0356	it plays a direct role in the translocation of protons across the membrane
TherJR_2896	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TherJR_2897	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TherJR_2898	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TherJR_2899	COG0698	ribose 5-phosphate isomerase
TherJR_2901	COG1971	Probably functions as a manganese efflux pump
TherJR_2902	COG0009	L-threonylcarbamoyladenylate synthase
TherJR_2903	COG0475	glutathione-regulated potassium exporter activity
TherJR_2904	COG2890	protein-(glutamine-N5) methyltransferase activity
TherJR_2905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TherJR_2906	COG3872	metal-dependent enzyme
TherJR_2907	COG0254	rRNA binding
TherJR_2909	COG0739	heme binding
TherJR_2912	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TherJR_2914	COG1494	fructose-1,6-bisphosphatase
TherJR_2915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TherJR_2919	COG2204	response regulator
TherJR_2921	COG0616	signal peptide processing
TherJR_2922	COG0504	CTP synthase activity
TherJR_2923	COG3343	RNA polymerase activity
TherJR_2924	COG0018	arginyl-trna synthetase
TherJR_2930	COG0436	Aminotransferase
TherJR_2931	COG1522	sequence-specific DNA binding
TherJR_2933	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TherJR_2935	COG3852	Histidine kinase
TherJR_2936	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TherJR_2937	COG2959	enzyme of heme biosynthesis
TherJR_2938	COG3409	Peptidoglycan-binding domain 1 protein
TherJR_2938	COG3773	Cell wall hydrolase
TherJR_2939	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TherJR_2940	COG1151	hydroxylamine reductase activity
TherJR_2944	COG5012	cobalamin binding
TherJR_2945	COG5598	trimethylamine methyltransferase
TherJR_2946	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TherJR_2947	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
TherJR_2948	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TherJR_2950	COG5012	cobalamin binding
TherJR_2951	COG1917	Cupin 2, conserved barrel domain protein
TherJR_2951	COG2207	Transcriptional regulator
TherJR_2952	COG1028	Short-chain dehydrogenase reductase Sdr
TherJR_2957	COG0409	Hydrogenase expression formation protein
TherJR_2959	COG1151	hydroxylamine reductase activity
TherJR_2965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TherJR_2966	COG0650	Formate hydrogenlyase subunit 4
TherJR_2967	COG0651	ATP synthesis coupled electron transport
TherJR_2969	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TherJR_2970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TherJR_2971	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TherJR_2972	COG0305	Participates in initiation and elongation during chromosome replication
TherJR_2973	COG0470	DNA polymerase III
TherJR_2973	COG1067	ATP-dependent peptidase activity
TherJR_2974	COG0359	binds to the 23S rRNA
TherJR_2977	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TherJR_2979	COG0360	Binds together with S18 to 16S ribosomal RNA
TherJR_2980	COG0012	GTP binding
TherJR_2982	COG0668	transmembrane transport
TherJR_2984	COG1362	aminopeptidase activity
TherJR_2992	COG2204	response regulator
TherJR_2999	COG1606	tRNA processing
TherJR_3000	COG1691	(AIR) carboxylase
TherJR_3003	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TherJR_3004	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TherJR_3005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TherJR_3008	COG1475	DNA binding
TherJR_3009	COG1192	Involved in chromosome partitioning
TherJR_3010	COG0357	Ribosomal RNA small subunit methyltransferase G
TherJR_3011	COG0445	tRNA wobble uridine modification
TherJR_3012	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TherJR_3013	COG1847	R3H domain protein
TherJR_3014	COG0706	membrane insertase activity
TherJR_3015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TherJR_3016	COG0594	ribonuclease P activity
TherJR_3017	COG0230	Belongs to the bacterial ribosomal protein bL34 family