locus-tag	class	description
Thebr_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thebr_0002	COG0592	DNA-directed DNA polymerase activity
Thebr_0003	COG2501	S4 domain
Thebr_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Thebr_0007	COG3442	glutamine amidotransferase
Thebr_0010	COG0187	DNA topoisomerase II activity
Thebr_0011	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Thebr_0012	COG1902	pentaerythritol trinitrate reductase activity
Thebr_0013	COG0440	acetolactate synthase activity
Thebr_0014	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Thebr_0015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thebr_0016	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thebr_0017	COG0066	3-isopropylmalate dehydratase activity
Thebr_0018	COG0473	3-isopropylmalate dehydrogenase activity
Thebr_0019	COG0129	dihydroxy-acid dehydratase activity
Thebr_0020	COG0028	Belongs to the TPP enzyme family
Thebr_0023	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Thebr_0023	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Thebr_0024	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Thebr_0025	COG0628	permease
Thebr_0029	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thebr_0030	COG0582	viral genome integration into host DNA
Thebr_0033	COG1396	sequence-specific DNA binding
Thebr_0043	COG2199	diguanylate cyclase activity
Thebr_0043	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thebr_0052	COG3344	reverse transcriptase
Thebr_0064	COG0739	heme binding
Thebr_0068	COG4962	Type ii secretion system protein e
Thebr_0079	COG3409	Peptidoglycan-binding domain 1 protein
Thebr_0079	COG3773	Cell wall hydrolase
Thebr_0094	COG0358	DNA primase activity
Thebr_0100	COG0582	viral genome integration into host DNA
Thebr_0102	COG0658	competence protein
Thebr_0102	COG2333	competence protein COMEC
Thebr_0104	COG3344	reverse transcriptase
Thebr_0105	COG0308	aminopeptidase N
Thebr_0106	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thebr_0108	COG0739	heme binding
Thebr_0110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thebr_0111	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thebr_0113	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Thebr_0115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thebr_0117	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Thebr_0121	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thebr_0122	COG0396	ATPase activity
Thebr_0123	COG0719	Fe-S assembly protein
Thebr_0125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thebr_0126	COG0822	iron-sulfur transferase activity
Thebr_0138	COG3340	Belongs to the peptidase S51 family
Thebr_0140	COG1518	maintenance of DNA repeat elements
Thebr_0141	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thebr_0143	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Thebr_0144	COG3344	reverse transcriptase
Thebr_0145	COG4492	Belongs to the UPF0735 family
Thebr_0146	COG0460	homoserine dehydrogenase
Thebr_0147	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Thebr_0148	COG0083	homoserine kinase activity
Thebr_0150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Thebr_0151	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thebr_0153	COG0504	CTP synthase activity
Thebr_0156	COG1349	DNA-binding transcription factor activity
Thebr_0158	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thebr_0158	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thebr_0158	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thebr_0161	COG0071	Belongs to the small heat shock protein (HSP20) family
Thebr_0164	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thebr_0165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thebr_0166	COG2088	sporulation resulting in formation of a cellular spore
Thebr_0167	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thebr_0168	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Thebr_0169	COG3344	reverse transcriptase
Thebr_0170	COG0745	RESPONSE REGULATOR receiver
Thebr_0171	COG5002	protein histidine kinase activity
Thebr_0172	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thebr_0173	COG0193	aminoacyl-tRNA hydrolase activity
Thebr_0175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Thebr_0176	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thebr_0177	COG2002	toxin-antitoxin pair type II binding
Thebr_0180	COG4466	Protein conserved in bacteria
Thebr_0181	COG1388	LysM domain
Thebr_0182	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Thebr_0183	COG1802	Transcriptional regulator
Thebr_0186	COG0697	spore germination
Thebr_0187	COG0531	amino acid
Thebr_0190	COG3409	Peptidoglycan-binding domain 1 protein
Thebr_0190	COG3773	Cell wall hydrolase
Thebr_0191	COG2959	enzyme of heme biosynthesis
Thebr_0193	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thebr_0195	COG0018	arginyl-trna synthetase
Thebr_0196	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thebr_0197	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Thebr_0199	COG1131	(ABC) transporter
Thebr_0204	COG4608	Belongs to the ABC transporter superfamily
Thebr_0205	COG0444	Belongs to the ABC transporter superfamily
Thebr_0207	COG0601	transmembrane transport
Thebr_0208	COG0747	negative chemotaxis
Thebr_0210	COG0667	Aldo Keto reductase
Thebr_0212	COG1012	belongs to the aldehyde dehydrogenase family
Thebr_0212	COG1454	alcohol dehydrogenase
Thebr_0215	COG1846	Transcriptional regulator
Thebr_0217	COG1132	(ABC) transporter
Thebr_0218	COG3859	Proton-coupled thiamine transporter YuaJ
Thebr_0219	COG0671	phosphoesterase, PA-phosphatase related
Thebr_0221	COG1796	DNA polymerase
Thebr_0221	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thebr_0222	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thebr_0222	COG0493	'glutamate synthase
Thebr_0229	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Thebr_0230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thebr_0231	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Thebr_0232	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thebr_0233	COG0505	Belongs to the CarA family
Thebr_0234	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Thebr_0235	COG0137	argininosuccinate synthase activity
Thebr_0236	COG0165	Argininosuccinate lyase
Thebr_0237	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thebr_0239	COG0588	phosphoglycerate mutase activity
Thebr_0240	COG1528	Iron-storage protein
Thebr_0249	COG2033	superoxide reductase activity
Thebr_0251	COG1027	Aspartate ammonia-lyase
Thebr_0252	COG1160	GTP binding
Thebr_0253	COG2814	Major facilitator Superfamily
Thebr_0255	COG3956	TIGRFAM MazG family protein
Thebr_0256	COG0776	regulation of translation
Thebr_0257	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Thebr_0258	COG2385	sporulation resulting in formation of a cellular spore
Thebr_0265	COG1098	S1 RNA binding domain
Thebr_0266	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thebr_0266	COG0248	Ppx GppA phosphatase
Thebr_0267	COG1940	carbohydrate kinase activity
Thebr_0268	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thebr_0269	COG1175	transmembrane transport
Thebr_0270	COG0395	ABC-type sugar transport system, permease component
Thebr_0272	COG3387	PFAM Glycoside hydrolase 15-related
Thebr_0276	COG3328	transposase activity
Thebr_0280	COG0745	RESPONSE REGULATOR receiver
Thebr_0281	COG2205	protein histidine kinase activity
Thebr_0286	COG2217	Heavy metal translocating P-type atpase
Thebr_0287	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thebr_0289	COG0482	sulfurtransferase activity
Thebr_0290	COG2217	Heavy metal translocating P-type atpase
Thebr_0292	COG3300	MHYT domain
Thebr_0292	COG5001	Diguanylate cyclase
Thebr_0296	COG0156	8-amino-7-oxononanoate synthase activity
Thebr_0297	COG1063	alcohol dehydrogenase
Thebr_0302	COG1131	(ABC) transporter
Thebr_0305	COG0697	spore germination
Thebr_0307	COG2208	phosphoserine phosphatase activity
Thebr_0308	COG0037	tRNA processing
Thebr_0311	COG3852	Histidine kinase
Thebr_0312	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Thebr_0315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Thebr_0317	COG0511	ligase activity, forming carbon-carbon bonds
Thebr_0317	COG5016	pyruvate
Thebr_0318	COG4684	Psort location CytoplasmicMembrane, score
Thebr_0319	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Thebr_0320	COG0531	amino acid
Thebr_0321	COG0697	spore germination
Thebr_0326	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thebr_0326	COG5322	oxidoreductase activity
Thebr_0327	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thebr_0328	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Thebr_0329	COG0302	gtp cyclohydrolase
Thebr_0330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thebr_0331	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thebr_0332	COG0720	synthase
Thebr_0333	COG1489	DNA binding
Thebr_0334	COG0823	Involved in the tonB-independent uptake of proteins
Thebr_0334	COG1506	peptidase
Thebr_0334	COG4946	Tricorn protease homolog
Thebr_0336	COG4224	UPF0291 protein
Thebr_0340	COG0745	RESPONSE REGULATOR receiver
Thebr_0340	COG3706	GGDEF domain
Thebr_0341	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thebr_0341	COG3711	transcriptional antiterminator
Thebr_0342	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thebr_0342	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thebr_0342	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thebr_0344	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thebr_0345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thebr_0346	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thebr_0347	COG0281	malic enzyme
Thebr_0350	COG3880	PFAM UvrB UvrC protein
Thebr_0351	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Thebr_0352	COG0542	response to heat
Thebr_0353	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Thebr_0355	COG4956	integral membrane protein (PIN domain superfamily)
Thebr_0356	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Thebr_0358	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Thebr_0359	COG0442	prolyl-tRNA aminoacylation
Thebr_0361	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thebr_0362	COG1045	serine acetyltransferase
Thebr_0363	COG0215	cysteine-tRNA ligase activity
Thebr_0365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thebr_0366	COG3688	RNA-binding protein containing a PIN domain
Thebr_0367	COG1595	DNA-templated transcription, initiation
Thebr_0368	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thebr_0369	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Thebr_0370	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thebr_0371	COG0250	Participates in transcription elongation, termination and antitermination
Thebr_0372	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thebr_0373	COG0081	regulation of translation
Thebr_0374	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Thebr_0375	COG0222	ribosome binding
Thebr_0376	COG0085	RNA polymerase activity
Thebr_0377	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thebr_0378	COG1358	cellular component organization or biogenesis
Thebr_0379	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Thebr_0380	COG0049	tRNA binding
Thebr_0381	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thebr_0382	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thebr_0383	COG0051	transcription antitermination factor activity, RNA binding
Thebr_0384	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thebr_0385	COG0088	Forms part of the polypeptide exit tunnel
Thebr_0386	COG0089	rRNA binding
Thebr_0387	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thebr_0388	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thebr_0389	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thebr_0390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thebr_0391	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Thebr_0392	COG0255	Belongs to the universal ribosomal protein uL29 family
Thebr_0393	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thebr_0394	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thebr_0395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thebr_0396	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thebr_0397	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Thebr_0398	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thebr_0399	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Thebr_0400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thebr_0401	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thebr_0402	COG0200	Binds to the 23S rRNA
Thebr_0403	COG0201	protein transport
Thebr_0404	COG0563	adenylate kinase activity
Thebr_0407	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thebr_0409	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thebr_0410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thebr_0411	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thebr_0412	COG0202	RNA polymerase activity
Thebr_0413	COG0203	ribosomal protein L17
Thebr_0414	COG1122	ATPase activity
Thebr_0415	COG1122	ATPase activity
Thebr_0416	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thebr_0417	COG0101	tRNA pseudouridine synthase activity
Thebr_0418	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thebr_0419	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thebr_0422	COG4555	ABC transporter
Thebr_0436	COG2801	Transposase and inactivated derivatives
Thebr_0441	COG2033	superoxide reductase activity
Thebr_0443	COG1966	Carbon starvation protein
Thebr_0444	COG1115	amino acid carrier protein
Thebr_0447	COG1320	monovalent cation:proton antiporter activity
Thebr_0451	COG0651	ATP synthesis coupled electron transport
Thebr_0452	COG0651	ATP synthesis coupled electron transport
Thebr_0454	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Thebr_0459	COG1388	LysM domain
Thebr_0459	COG1705	Flagellar rod assembly protein muramidase FlgJ
Thebr_0461	COG0546	phosphoglycolate phosphatase activity
Thebr_0464	COG0714	Associated with various cellular activities
Thebr_0469	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Thebr_0471	COG3426	butyrate kinase activity
Thebr_0472	COG0280	phosphate acetyltransferase
Thebr_0473	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Thebr_0474	COG3426	butyrate kinase activity
Thebr_0480	COG0280	phosphate acetyltransferase
Thebr_0482	COG0204	Acyl-transferase
Thebr_0482	COG0318	PFAM AMP-dependent synthetase and ligase
Thebr_0483	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thebr_0484	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thebr_0486	COG0432	Pfam Uncharacterised protein family UPF0047
Thebr_0487	COG1793	dna ligase
Thebr_0488	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Thebr_0492	COG1151	hydroxylamine reductase activity
Thebr_0496	COG0736	holo-[acyl-carrier-protein] synthase activity
Thebr_0497	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thebr_0497	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thebr_0499	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thebr_0501	COG2337	Toxic component of a toxin-antitoxin (TA) module
Thebr_0503	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thebr_0504	COG3959	Transketolase, thiamine diphosphate binding domain
Thebr_0505	COG3958	Transketolase
Thebr_0507	COG0205	6-phosphofructokinase activity
Thebr_0508	COG1757	Na H antiporter
Thebr_0509	COG2205	protein histidine kinase activity
Thebr_0510	COG1773	rubredoxin
Thebr_0511	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Thebr_0513	COG0460	homoserine dehydrogenase
Thebr_0515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Thebr_0516	COG0673	inositol 2-dehydrogenase activity
Thebr_0517	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thebr_0517	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Thebr_0518	COG3459	Glycosyltransferase 36 associated
Thebr_0520	COG1131	(ABC) transporter
Thebr_0529	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Thebr_0530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Thebr_0531	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thebr_0532	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thebr_0533	COG0131	Imidazoleglycerol-phosphate dehydratase
Thebr_0534	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thebr_0537	COG0140	phosphoribosyl-ATP diphosphatase activity
Thebr_0537	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Thebr_0538	COG3344	reverse transcriptase
Thebr_0539	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thebr_0541	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thebr_0542	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Thebr_0544	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thebr_0549	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Thebr_0550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thebr_0551	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Thebr_0553	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thebr_0555	COG3290	protein histidine kinase activity
Thebr_0555	COG3829	transcription factor binding
Thebr_0556	COG2376	Dihydroxyacetone kinase
Thebr_0558	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thebr_0558	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Thebr_0558	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thebr_0559	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thebr_0568	COG0849	cell division
Thebr_0572	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thebr_0573	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Thebr_0574	COG0019	diaminopimelate decarboxylase activity
Thebr_0576	COG3842	ATPase activity
Thebr_0577	COG3835	regulator
Thebr_0578	COG2884	Cell division ATP-binding protein ftsE
Thebr_0579	COG2177	Part of the ABC transporter FtsEX involved in
Thebr_0580	COG0739	heme binding
Thebr_0581	COG0793	Belongs to the peptidase S41A family
Thebr_0581	COG3409	Peptidoglycan-binding domain 1 protein
Thebr_0582	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thebr_0583	COG2045	Belongs to the ComB family
Thebr_0584	COG0556	nucleotide-excision repair
Thebr_0586	COG1716	ATPase activity
Thebr_0588	COG0768	penicillin binding
Thebr_0589	COG0322	excinuclease ABC activity
Thebr_0591	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Thebr_0593	COG1940	carbohydrate kinase activity
Thebr_0594	COG0318	PFAM AMP-dependent synthetase and ligase
Thebr_0596	COG2078	PFAM AMMECR1 domain protein
Thebr_0596	COG3885	ferrous iron binding
Thebr_0606	COG0673	inositol 2-dehydrogenase activity
Thebr_0607	COG0673	inositol 2-dehydrogenase activity
Thebr_0612	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thebr_0613	COG1349	DNA-binding transcription factor activity
Thebr_0614	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thebr_0615	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thebr_0620	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Thebr_0621	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Thebr_0622	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thebr_0623	COG1940	carbohydrate kinase activity
Thebr_0629	COG3250	beta-galactosidase activity
Thebr_0630	COG0383	alpha-mannosidase activity
Thebr_0631	COG1653	transport
Thebr_0632	COG1175	transmembrane transport
Thebr_0633	COG0395	ABC-type sugar transport system, permease component
Thebr_0635	COG4977	sequence-specific DNA binding
Thebr_0635	COG1917	Cupin 2, conserved barrel domain protein
Thebr_0637	COG0733	neurotransmitter:sodium symporter activity
Thebr_0641	COG0768	penicillin binding
Thebr_0643	COG2182	Extracellular solute-binding protein
Thebr_0646	COG1621	beta-fructofuranosidase activity
Thebr_0647	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thebr_0648	COG1609	Transcriptional regulator
Thebr_0652	COG2226	methyltransferase
Thebr_0655	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thebr_0656	COG0489	protein tyrosine kinase activity
Thebr_0659	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thebr_0661	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thebr_0662	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thebr_0664	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thebr_0665	COG1120	ATPase activity
Thebr_0672	COG1342	Belongs to the UPF0251 family
Thebr_0677	COG3464	Transposase
Thebr_0680	COG1752	Esterase of the alpha-beta hydrolase superfamily
Thebr_0682	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Thebr_0687	COG2182	Extracellular solute-binding protein
Thebr_0688	COG1175	transmembrane transport
Thebr_0689	COG3833	ABC-type maltose transport systems, permease component
Thebr_0693	COG1426	Protein conserved in bacteria
Thebr_0694	COG0366	Alpha amylase catalytic
Thebr_0696	COG1481	regulation of sporulation
Thebr_0697	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thebr_0698	COG4109	DRTGG domain
Thebr_0701	COG0205	6-phosphofructokinase activity
Thebr_0704	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thebr_0707	COG0534	Mate efflux family protein
Thebr_0708	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thebr_0711	COG2195	Cleaves the N-terminal amino acid of tripeptides
Thebr_0712	COG0778	Nitroreductase
Thebr_0713	COG0166	Belongs to the GPI family
Thebr_0714	COG0058	SHG alpha-glucan phosphorylase activity
Thebr_0716	COG0646	methionine synthase
Thebr_0716	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Thebr_0717	COG1410	methionine synthase
Thebr_0717	COG0646	methionine synthase
Thebr_0718	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Thebr_0719	COG3546	catalase activity
Thebr_0722	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thebr_0728	COG0463	Glycosyl transferase, family 2
Thebr_0729	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thebr_0731	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Thebr_0735	COG0564	pseudouridine synthase activity
Thebr_0737	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thebr_0744	COG1067	ATP-dependent peptidase activity
Thebr_0745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thebr_0746	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thebr_0747	COG2720	vancomycin resistance protein
Thebr_0749	COG0561	phosphatase activity
Thebr_0750	COG1254	Belongs to the acylphosphatase family
Thebr_0751	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Thebr_0752	COG2390	Transcriptional regulator
Thebr_0754	COG0126	phosphoglycerate kinase activity
Thebr_0755	COG0149	triose-phosphate isomerase activity
Thebr_0757	COG0148	phosphopyruvate hydratase activity
Thebr_0758	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thebr_0759	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Thebr_0760	COG0358	DNA primase activity
Thebr_0761	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thebr_0762	COG2384	SAM-dependent methyltransferase
Thebr_0763	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Thebr_0764	COG0813	purine-nucleoside phosphorylase activity
Thebr_0765	COG1482	cell wall glycoprotein biosynthetic process
Thebr_0767	COG0475	glutathione-regulated potassium exporter activity
Thebr_0770	COG0701	Predicted permease
Thebr_0772	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thebr_0773	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thebr_0774	COG1956	GAF domain-containing protein
Thebr_0775	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Thebr_0779	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Thebr_0780	COG1278	Cold shock
Thebr_0781	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Thebr_0782	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thebr_0783	COG0745	RESPONSE REGULATOR receiver
Thebr_0786	COG4399	Belongs to the UPF0754 family
Thebr_0787	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thebr_0789	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Thebr_0790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Thebr_0791	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Thebr_0792	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Thebr_0793	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thebr_0794	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Thebr_0795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thebr_0795	COG0072	phenylalanine-tRNA ligase activity
Thebr_0797	COG0826	peptidase U32
Thebr_0798	COG1193	negative regulation of DNA recombination
Thebr_0799	COG1683	Conserved Protein
Thebr_0802	COG2197	response regulator
Thebr_0803	COG1362	aminopeptidase activity
Thebr_0804	COG2340	Cysteine-rich secretory protein family
Thebr_0807	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thebr_0808	COG0321	lipoyl(octanoyl) transferase activity
Thebr_0809	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Thebr_0811	COG0459	protein refolding
Thebr_0812	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Thebr_0813	COG0022	dehydrogenase e1 component
Thebr_0814	COG3199	ATP-NAD kinase
Thebr_0815	COG0508	dehydrogenase complex catalyzes the overall conversion of
Thebr_0820	COG0301	tRNA thio-modification
Thebr_0822	COG0012	GTP binding
Thebr_0824	COG0612	Peptidase, M16
Thebr_0825	COG0612	Peptidase, M16
Thebr_0826	COG2001	Belongs to the MraZ family
Thebr_0827	COG0275	rRNA processing
Thebr_0828	COG3116	cell division
Thebr_0829	COG0768	penicillin binding
Thebr_0830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thebr_0831	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thebr_0832	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thebr_0833	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Thebr_0834	COG0772	Belongs to the SEDS family
Thebr_0835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thebr_0836	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thebr_0839	COG3856	small basic protein
Thebr_0840	COG0849	cell division
Thebr_0841	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thebr_0843	COG1191	sigma factor activity
Thebr_0844	COG1191	sigma factor activity
Thebr_0845	COG1873	PFAM PRC-barrel domain
Thebr_0846	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Thebr_0847	COG0745	RESPONSE REGULATOR receiver
Thebr_0848	COG5002	protein histidine kinase activity
Thebr_0849	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thebr_0850	COG0573	inorganic phosphate transmembrane transporter activity
Thebr_0851	COG0581	inorganic phosphate transmembrane transporter activity
Thebr_0852	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thebr_0853	COG0704	Plays a role in the regulation of phosphate uptake
Thebr_0861	COG1160	GTP binding
Thebr_0862	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thebr_0863	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Thebr_0867	COG3835	regulator
Thebr_0872	COG2414	aldehyde ferredoxin oxidoreductase
Thebr_0875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Thebr_0881	COG0521	Mo-molybdopterin cofactor biosynthetic process
Thebr_0882	COG0303	'Molybdopterin
Thebr_0883	COG1910	domain protein
Thebr_0885	COG0315	cyclic pyranopterin monophosphate synthase activity
Thebr_0893	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Thebr_0894	COG1799	cell septum assembly
Thebr_0896	COG2302	S4 RNA-binding domain
Thebr_0897	COG3599	regulation of cell shape
Thebr_0899	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thebr_0900	COG0402	S-adenosylhomocysteine deaminase activity
Thebr_0901	COG0235	Class ii aldolase
Thebr_0902	COG2188	Transcriptional regulator
Thebr_0904	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Thebr_0905	COG1122	ATPase activity
Thebr_0907	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Thebr_0912	COG3344	reverse transcriptase
Thebr_0914	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thebr_0914	COG0512	Glutamine amidotransferase of anthranilate synthase
Thebr_0915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thebr_0916	COG0134	indole-3-glycerol-phosphate synthase activity
Thebr_0917	COG0135	phosphoribosylanthranilate isomerase activity
Thebr_0918	COG0133	tryptophan synthase activity
Thebr_0919	COG0159	tryptophan synthase activity
Thebr_0920	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thebr_0921	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thebr_0922	COG0626	cystathionine gamma-synthase activity
Thebr_0929	COG1703	isobutyryl-CoA mutase activity
Thebr_0930	COG0346	lactoylglutathione lyase activity
Thebr_0932	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Thebr_0935	COG1595	DNA-templated transcription, initiation
Thebr_0936	COG0778	Nitroreductase
Thebr_0938	COG1970	mechanosensitive ion channel activity
Thebr_0953	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thebr_0961	COG1132	(ABC) transporter
Thebr_0972	COG1132	(ABC) transporter
Thebr_0978	COG1132	(ABC) transporter
Thebr_0982	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Thebr_0984	COG0693	protein deglycase activity
Thebr_0986	COG2267	carboxylic ester hydrolase activity
Thebr_0987	COG3344	reverse transcriptase
Thebr_0990	COG0584	glycerophosphoryl diester phosphodiesterase
Thebr_0992	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Thebr_0993	COG1968	undecaprenyl-diphosphatase activity
Thebr_0996	COG3069	C4-dicarboxylate transmembrane transporter activity
Thebr_0998	COG0426	domain, Protein
Thebr_0999	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thebr_1001	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Thebr_1002	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Thebr_1003	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Thebr_1006	COG1760	l-serine dehydratase
Thebr_1007	COG1164	Oligoendopeptidase f
Thebr_1008	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thebr_1009	COG0077	Prephenate dehydratase
Thebr_1009	COG1605	Chorismate mutase
Thebr_1010	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thebr_1011	COG0287	Prephenate dehydrogenase
Thebr_1012	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thebr_1014	COG3773	Cell wall hydrolase
Thebr_1014	COG3409	Peptidoglycan-binding domain 1 protein
Thebr_1015	COG2119	membrane
Thebr_1018	COG0363	glucosamine-6-phosphate deaminase activity
Thebr_1019	COG0785	Cytochrome C biogenesis protein
Thebr_1020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thebr_1021	COG3118	belongs to the thioredoxin family
Thebr_1022	COG1982	Orn Lys Arg decarboxylase major
Thebr_1026	COG2385	sporulation resulting in formation of a cellular spore
Thebr_1027	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thebr_1030	COG1739	Uncharacterized protein family UPF0029
Thebr_1034	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thebr_1035	COG0217	transcriptional regulatory protein
Thebr_1036	COG0835	chemotaxis
Thebr_1038	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thebr_1039	COG0632	four-way junction helicase activity
Thebr_1040	COG2255	four-way junction helicase activity
Thebr_1042	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Thebr_1043	COG0343	queuine tRNA-ribosyltransferase activity
Thebr_1047	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thebr_1048	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Thebr_1049	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thebr_1050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thebr_1050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thebr_1052	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Thebr_1052	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Thebr_1053	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thebr_1054	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thebr_1055	COG1490	D-aminoacyl-tRNA deacylase activity
Thebr_1056	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thebr_1057	COG0577	efflux transmembrane transporter activity
Thebr_1058	COG1136	(ABC) transporter
Thebr_1062	COG0124	histidyl-tRNA synthetase
Thebr_1063	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Thebr_1064	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thebr_1065	COG1937	Protein conserved in bacteria
Thebr_1066	COG3118	belongs to the thioredoxin family
Thebr_1067	COG3804	dihydrodipicolinate reductase
Thebr_1069	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thebr_1071	COG5012	cobalamin binding
Thebr_1073	COG3457	Alanine racemase
Thebr_1074	COG0346	lactoylglutathione lyase activity
Thebr_1075	COG1959	2 iron, 2 sulfur cluster binding
Thebr_1076	COG0482	sulfurtransferase activity
Thebr_1078	COG0628	permease
Thebr_1079	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thebr_1080	COG4472	Bacterial protein of unknown function (DUF965)
Thebr_1081	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Thebr_1082	COG3906	Belongs to the UPF0473 family
Thebr_1083	COG0735	belongs to the Fur family
Thebr_1084	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Thebr_1085	COG3679	Belongs to the UPF0342 family
Thebr_1086	COG4708	membrane
Thebr_1087	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thebr_1090	COG0768	penicillin binding
Thebr_1091	COG1191	sigma factor activity
Thebr_1093	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thebr_1098	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Thebr_1107	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Thebr_1109	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thebr_1110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Thebr_1111	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Thebr_1112	COG0006	proline dipeptidase activity
Thebr_1113	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Thebr_1115	COG3854	ATPases associated with a variety of cellular activities
Thebr_1123	COG1302	Protein conserved in bacteria
Thebr_1124	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thebr_1125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thebr_1126	COG1570	exodeoxyribonuclease VII activity
Thebr_1127	COG1722	exodeoxyribonuclease VII activity
Thebr_1130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Thebr_1131	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Thebr_1132	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thebr_1133	COG1438	arginine binding
Thebr_1134	COG0497	DNA recombination
Thebr_1135	COG0750	zinc metalloprotease
Thebr_1144	COG1379	DNA repair
Thebr_1145	COG1300	Membrane
Thebr_1146	COG4974	Belongs to the 'phage' integrase family
Thebr_1147	COG1686	Belongs to the peptidase S11 family
Thebr_1148	COG1366	Belongs to the anti-sigma-factor antagonist family
Thebr_1149	COG2172	sigma factor antagonist activity
Thebr_1151	COG3360	Dodecin
Thebr_1155	COG0617	tRNA 3'-terminal CCA addition
Thebr_1156	COG1994	Peptidase M50
Thebr_1157	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Thebr_1158	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thebr_1159	COG4086	secreted protein
Thebr_1161	COG3874	Sporulation protein YtfJ
Thebr_1162	COG1301	dicarboxylic acid transport
Thebr_1163	COG1030	water channel activity
Thebr_1164	COG4864	UPF0365 protein
Thebr_1166	COG1686	Belongs to the peptidase S11 family
Thebr_1168	COG0445	tRNA wobble uridine modification
Thebr_1169	COG1187	pseudouridine synthase activity
Thebr_1171	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thebr_1172	COG0010	Belongs to the arginase family
Thebr_1174	COG1705	Flagellar rod assembly protein muramidase FlgJ
Thebr_1174	COG1388	LysM domain
Thebr_1176	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Thebr_1178	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thebr_1178	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thebr_1179	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thebr_1184	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Thebr_1185	COG1914	H( )-stimulated, divalent metal cation uptake system
Thebr_1186	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Thebr_1187	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Thebr_1188	COG1984	allophanate hydrolase subunit 2
Thebr_1189	COG4336	lyase activity
Thebr_1192	COG0406	alpha-ribazole phosphatase activity
Thebr_1193	COG2081	HI0933 family
Thebr_1196	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Thebr_1198	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thebr_1199	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thebr_1199	COG0539	negative regulation of cytoplasmic translation
Thebr_1200	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thebr_1201	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thebr_1202	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thebr_1203	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thebr_1204	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Thebr_1205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Thebr_1206	COG1923	regulation of RNA biosynthetic process
Thebr_1207	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Thebr_1208	COG0328	RNA-DNA hybrid ribonuclease activity
Thebr_1209	COG4974	Belongs to the 'phage' integrase family
Thebr_1210	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Thebr_1211	COG0464	growth
Thebr_1212	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Thebr_1214	COG0613	PHP domain protein
Thebr_1215	COG2359	stage V sporulation protein S
Thebr_1216	COG1692	metallophosphoesterase
Thebr_1217	COG1418	mRNA catabolic process
Thebr_1219	COG2137	regulation of response to DNA damage stimulus
Thebr_1220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Thebr_1221	COG1058	Belongs to the CinA family
Thebr_1221	COG1546	Belongs to the CinA family
Thebr_1222	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thebr_1223	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thebr_1224	COG1674	ftsk spoiiie
Thebr_1226	COG0740	serine-type endopeptidase activity
Thebr_1227	COG0527	aspartate kinase activity
Thebr_1229	COG0756	dUTP diphosphatase activity
Thebr_1230	COG0612	Peptidase, M16
Thebr_1231	COG0726	polysaccharide deacetylase
Thebr_1232	COG1185	polyribonucleotide nucleotidyltransferase activity
Thebr_1233	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Thebr_1234	COG0196	riboflavin kinase activity
Thebr_1235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thebr_1236	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Thebr_1237	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thebr_1238	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Thebr_1240	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Thebr_1241	COG0195	Participates in both transcription termination and antitermination
Thebr_1242	COG0779	Required for maturation of 30S ribosomal subunits
Thebr_1243	COG2176	DNA-directed DNA polymerase activity
Thebr_1245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Thebr_1246	COG0750	zinc metalloprotease
Thebr_1247	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Thebr_1248	COG4589	Belongs to the CDS family
Thebr_1249	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Thebr_1251	COG0233	cytoplasmic translational termination
Thebr_1252	COG0528	UMP kinase activity
Thebr_1253	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thebr_1254	COG0052	Belongs to the universal ribosomal protein uS2 family
Thebr_1257	COG1191	sigma factor activity
Thebr_1258	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thebr_1259	COG1776	CheC inhibitor of MCP methylation
Thebr_1260	COG0835	chemotaxis
Thebr_1261	COG2198	Histidine kinase
Thebr_1261	COG0643	Histidine kinase
Thebr_1262	COG2201	protein-glutamate methylesterase activity
Thebr_1264	COG0455	bacterial-type flagellum organization
Thebr_1265	COG1419	protein localization to endoplasmic reticulum
Thebr_1266	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thebr_1267	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thebr_1268	COG1684	flagellar biosynthetic protein fliR
Thebr_1269	COG1987	bacterial-type flagellum assembly
Thebr_1270	COG1338	Plays a role in the flagellum-specific transport system
Thebr_1272	COG2201	protein-glutamate methylesterase activity
Thebr_1273	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thebr_1273	COG1776	CheC inhibitor of MCP methylation
Thebr_1274	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thebr_1276	COG1582	Flagellar protein (FlbD)
Thebr_1279	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Thebr_1283	COG1157	protein secretion by the type III secretion system
Thebr_1285	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thebr_1286	COG1766	The M ring may be actively involved in energy transduction
Thebr_1287	COG1677	Flagellar hook-basal body complex protein FliE
Thebr_1289	COG1815	bacterial-type flagellum-dependent cell motility
Thebr_1290	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Thebr_1291	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Thebr_1292	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Thebr_1293	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thebr_1294	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thebr_1294	COG0758	DNA mediated transformation
Thebr_1295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thebr_1296	COG0792	nuclease activity
Thebr_1297	COG0180	Tryptophanyl-tRNA synthetase
Thebr_1298	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thebr_1299	COG0606	chelatase, subunit chli
Thebr_1301	COG0335	large ribosomal subunit rRNA binding
Thebr_1302	COG0336	Belongs to the RNA methyltransferase TrmD family
Thebr_1303	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Thebr_1304	COG1837	Belongs to the UPF0109 family
Thebr_1305	COG0228	four-way junction DNA binding
Thebr_1306	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thebr_1307	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Thebr_1308	COG0552	protein localization to endoplasmic reticulum
Thebr_1311	COG2359	stage V sporulation protein S
Thebr_1313	COG0571	ribonuclease III activity
Thebr_1314	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thebr_1315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thebr_1316	COG1028	Short-chain dehydrogenase reductase Sdr
Thebr_1317	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Thebr_1318	COG2070	2-Nitropropane dioxygenase
Thebr_1319	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thebr_1320	COG0416	fatty acid biosynthetic process
Thebr_1321	COG2030	dehydratase
Thebr_1322	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thebr_1323	COG1399	metal-binding, possibly nucleic acid-binding protein
Thebr_1324	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Thebr_1325	COG0280	phosphate acetyltransferase
Thebr_1326	COG1323	Belongs to the UPF0348 family
Thebr_1327	COG3314	Sporulation integral membrane protein YlbJ
Thebr_1329	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thebr_1330	COG0742	ribosomal rna small subunit methyltransferase
Thebr_1333	COG1307	EDD domain protein, DegV family
Thebr_1334	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thebr_1335	COG1461	Dihydroxyacetone kinase
Thebr_1336	COG1302	Protein conserved in bacteria
Thebr_1337	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Thebr_1340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thebr_1341	COG1162	GTPase activity
Thebr_1342	COG0515	serine threonine protein kinase
Thebr_1342	COG2815	serine threonine protein kinase
Thebr_1343	COG0631	protein serine/threonine phosphatase activity
Thebr_1344	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thebr_1345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thebr_1345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thebr_1346	COG2738	Putative neutral zinc metallopeptidase
Thebr_1348	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thebr_1349	COG0242	peptide deformylase activity
Thebr_1350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thebr_1351	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thebr_1352	COG1758	RNA polymerase activity
Thebr_1353	COG0194	GDP metabolic process
Thebr_1354	COG2052	Domain of unknown function (DUF370)
Thebr_1355	COG1561	YicC-like family, N-terminal region
Thebr_1356	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thebr_1357	COG2814	Major facilitator Superfamily
Thebr_1361	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thebr_1362	COG2011	ABC-type metal ion transport system permease component
Thebr_1365	COG0037	tRNA processing
Thebr_1368	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thebr_1369	COG0167	dihydroorotate dehydrogenase activity
Thebr_1370	COG0543	2 iron, 2 sulfur cluster binding
Thebr_1371	COG0284	orotidine-5'-phosphate decarboxylase activity
Thebr_1372	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thebr_1373	COG0540	Belongs to the ATCase OTCase family
Thebr_1374	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Thebr_1376	COG0564	pseudouridine synthase activity
Thebr_1377	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Thebr_1379	COG3063	Type IV pilus biogenesis stability protein PilW
Thebr_1383	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Thebr_1384	COG0557	exoribonuclease II activity
Thebr_1386	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thebr_1386	COG0574	Belongs to the PEP-utilizing enzyme family
Thebr_1387	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Thebr_1388	COG0517	IMP dehydrogenase activity
Thebr_1389	COG0423	glycine-tRNA ligase activity
Thebr_1391	COG1381	Involved in DNA repair and RecF pathway recombination
Thebr_1392	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Thebr_1393	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Thebr_1394	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Thebr_1395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Thebr_1396	COG1480	7TM receptor with intracellular HD hydrolase
Thebr_1397	COG1702	phosphate starvation-inducible protein PhoH
Thebr_1402	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thebr_1403	COG0537	adenosine 5'-monophosphoramidase activity
Thebr_1404	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thebr_1406	COG5002	protein histidine kinase activity
Thebr_1406	COG5001	Diguanylate cyclase
Thebr_1406	COG3447	MASE1 domain protein
Thebr_1407	COG0840	transmembrane signaling receptor activity
Thebr_1417	COG2274	protein secretion by the type I secretion system
Thebr_1418	COG0488	(ABC) transporter
Thebr_1425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Thebr_1426	COG2264	protein methyltransferase activity
Thebr_1427	COG0484	heat shock protein binding
Thebr_1428	COG0443	Heat shock 70 kDa protein
Thebr_1429	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thebr_1430	COG1420	regulation of RNA biosynthetic process
Thebr_1431	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thebr_1432	COG0481	GTPase activity
Thebr_1437	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Thebr_1439	COG0268	Binds directly to 16S ribosomal RNA
Thebr_1442	COG1234	tRNA 3'-trailer cleavage
Thebr_1444	COG4720	Psort location CytoplasmicMembrane, score
Thebr_1448	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Thebr_1454	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thebr_1455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Thebr_1456	COG1596	polysaccharide export
Thebr_1456	COG1555	photosystem II stabilization
Thebr_1457	COG1686	Belongs to the peptidase S11 family
Thebr_1458	COG0367	asparagine synthase
Thebr_1462	COG0799	negative regulation of ribosome biogenesis
Thebr_1463	COG1713	HD superfamily hydrolase involved in NAD metabolism
Thebr_1464	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Thebr_1465	COG3344	reverse transcriptase
Thebr_1466	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thebr_1468	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Thebr_1470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thebr_1472	COG4708	membrane
Thebr_1473	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thebr_1474	COG1530	ribonuclease E activity
Thebr_1477	COG0517	IMP dehydrogenase activity
Thebr_1477	COG1994	Peptidase M50
Thebr_1478	COG0739	heme binding
Thebr_1479	COG1803	Methylglyoxal synthase
Thebr_1480	COG0772	Belongs to the SEDS family
Thebr_1481	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Thebr_1482	COG2894	cell division
Thebr_1483	COG0850	regulation of cytokinetic process
Thebr_1484	COG0768	penicillin binding
Thebr_1487	COG1077	Cell shape determining protein MreB Mrl
Thebr_1488	COG2003	Belongs to the UPF0758 family
Thebr_1489	COG0424	maF-like protein
Thebr_1494	COG4191	Histidine kinase
Thebr_1494	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thebr_1498	COG2878	Part of a membrane complex involved in electron transport
Thebr_1502	COG0741	lytic transglycosylase activity
Thebr_1504	COG1388	LysM domain
Thebr_1504	COG0791	NLP P60 protein
Thebr_1507	COG0741	lytic transglycosylase activity
Thebr_1508	COG0237	dephospho-CoA kinase activity
Thebr_1509	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thebr_1509	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thebr_1514	COG4475	Protein of unknown function (DUF436)
Thebr_1523	COG2986	histidine ammonia-lyase
Thebr_1526	COG0739	heme binding
Thebr_1529	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Thebr_1530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thebr_1534	COG1132	(ABC) transporter
Thebr_1535	COG1132	(ABC) transporter
Thebr_1537	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Thebr_1538	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thebr_1539	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Thebr_1540	COG2171	N-acyltransferase activity
Thebr_1541	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Thebr_1544	COG3409	Peptidoglycan-binding domain 1 protein
Thebr_1544	COG3773	Cell wall hydrolase
Thebr_1550	COG0395	ABC-type sugar transport system, permease component
Thebr_1553	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thebr_1554	COG0395	ABC-type sugar transport system, permease component
Thebr_1555	COG1175	transmembrane transport
Thebr_1558	COG1609	Transcriptional regulator
Thebr_1559	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thebr_1564	COG0285	dihydrofolate synthase activity
Thebr_1566	COG0525	valine-tRNA ligase activity
Thebr_1571	COG0745	RESPONSE REGULATOR receiver
Thebr_1572	COG5002	protein histidine kinase activity
Thebr_1573	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Thebr_1574	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Thebr_1575	COG1691	(AIR) carboxylase
Thebr_1576	COG1606	tRNA processing
Thebr_1577	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thebr_1579	COG0671	phosphoesterase, PA-phosphatase related
Thebr_1582	COG2814	Major facilitator Superfamily
Thebr_1583	COG0105	UTP biosynthetic process
Thebr_1585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thebr_1587	COG3949	Membrane
Thebr_1588	COG1316	TRANSCRIPTIONal
Thebr_1590	COG0489	protein tyrosine kinase activity
Thebr_1591	COG3944	biosynthesis protein
Thebr_1592	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thebr_1594	COG0250	Participates in transcription elongation, termination and antitermination
Thebr_1595	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Thebr_1596	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Thebr_1606	COG1914	H( )-stimulated, divalent metal cation uptake system
Thebr_1608	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thebr_1612	COG4989	oxidoreductase activity
Thebr_1613	COG0622	Phosphoesterase
Thebr_1614	COG1704	LemA family
Thebr_1615	COG0501	Belongs to the peptidase M48B family
Thebr_1619	COG2161	toxin-antitoxin pair type II binding
Thebr_1623	COG1401	restriction endodeoxyribonuclease activity
Thebr_1629	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thebr_1631	COG0789	Transcriptional regulator
Thebr_1637	COG1979	alcohol dehydrogenase
Thebr_1638	COG0667	Aldo Keto reductase
Thebr_1656	COG0622	Phosphoesterase
Thebr_1657	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Thebr_1668	COG1091	dTDP-4-dehydrorhamnose reductase activity
Thebr_1672	COG0463	Glycosyl transferase, family 2
Thebr_1672	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Thebr_1681	COG2239	Acts as a magnesium transporter
Thebr_1683	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Thebr_1684	COG1116	anion transmembrane transporter activity
Thebr_1685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thebr_1686	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thebr_1686	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thebr_1688	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Thebr_1689	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thebr_1690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thebr_1691	COG0740	serine-type endopeptidase activity
Thebr_1692	COG0544	peptidyl-prolyl cis-trans isomerase activity
Thebr_1694	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Thebr_1695	COG0352	thiamine-phosphate diphosphorylase activity
Thebr_1696	COG0351	phosphomethylpyrimidine kinase
Thebr_1699	COG0437	4 iron, 4 sulfur cluster binding
Thebr_1700	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Thebr_1700	COG0069	glutamate synthase activity
Thebr_1701	COG0067	glutamate synthase
Thebr_1702	COG0505	Belongs to the CarA family
Thebr_1704	COG0347	Belongs to the P(II) protein family
Thebr_1705	COG0004	ammonium transporteR
Thebr_1708	COG3464	Transposase
Thebr_1715	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Thebr_1718	COG2721	sulfolactate sulfo-lyase activity
Thebr_1723	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Thebr_1724	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thebr_1726	COG4608	Belongs to the ABC transporter superfamily
Thebr_1727	COG0444	Belongs to the ABC transporter superfamily
Thebr_1728	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thebr_1729	COG0601	transmembrane transport
Thebr_1730	COG4166	transmembrane transport
Thebr_1732	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thebr_1733	COG0154	amidase activity
Thebr_1734	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thebr_1735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Thebr_1736	COG0210	DNA helicase
Thebr_1737	COG4496	protein, YerC YecD
Thebr_1738	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thebr_1739	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thebr_1740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thebr_1742	COG3711	transcriptional antiterminator
Thebr_1744	COG2244	polysaccharide biosynthetic process
Thebr_1745	COG1473	amidohydrolase
Thebr_1746	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Thebr_1748	COG0151	Belongs to the GarS family
Thebr_1749	COG0138	bifunctional purine biosynthesis protein purh
Thebr_1750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thebr_1751	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Thebr_1752	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Thebr_1753	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thebr_1754	COG0047	phosphoribosylformylglycinamidine synthase activity
Thebr_1755	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thebr_1756	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thebr_1757	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thebr_1758	COG2252	PERMEase
Thebr_1759	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thebr_1759	COG0519	Catalyzes the synthesis of GMP from XMP
Thebr_1760	COG0517	IMP dehydrogenase activity
Thebr_1760	COG0516	GMP reductase activity
Thebr_1761	COG0459	protein refolding
Thebr_1762	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thebr_1768	COG1404	Belongs to the peptidase S8 family
Thebr_1770	COG1811	Na channel or pump
Thebr_1773	COG0493	'glutamate synthase
Thebr_1778	COG3290	protein histidine kinase activity
Thebr_1779	COG3279	Response regulator of the LytR AlgR family
Thebr_1781	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Thebr_1787	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thebr_1789	COG1214	PFAM Peptidase M22, glycoprotease
Thebr_1790	COG0802	atpase or kinase
Thebr_1792	COG0549	Belongs to the carbamate kinase family
Thebr_1793	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thebr_1794	COG2235	arginine
Thebr_1796	COG0398	Pfam SNARE associated Golgi protein
Thebr_1798	COG2183	response to ionizing radiation
Thebr_1800	COG0653	protein targeting
Thebr_1803	COG1827	regulation of RNA biosynthetic process
Thebr_1809	COG0765	amino acid transport
Thebr_1810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thebr_1811	COG3344	reverse transcriptase
Thebr_1813	COG0840	transmembrane signaling receptor activity
Thebr_1815	COG1516	flagellar protein fliS
Thebr_1816	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Thebr_1819	COG0367	asparagine synthase
Thebr_1825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Thebr_1826	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Thebr_1828	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thebr_1829	COG1256	bacterial-type flagellum assembly
Thebr_1829	COG4786	Flagellar basal body rod
Thebr_1833	COG1040	competence protein
Thebr_1834	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Thebr_1835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thebr_1836	COG1592	Rubrerythrin
Thebr_1840	COG5002	protein histidine kinase activity
Thebr_1841	COG0745	RESPONSE REGULATOR receiver
Thebr_1842	COG1609	Transcriptional regulator
Thebr_1844	COG0561	phosphatase activity
Thebr_1845	COG2323	membrane
Thebr_1848	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thebr_1849	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Thebr_1853	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Thebr_1855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thebr_1856	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Thebr_1857	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thebr_1858	COG2081	HI0933 family
Thebr_1867	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thebr_1868	COG3711	transcriptional antiterminator
Thebr_1869	COG2190	(PTS) system
Thebr_1870	COG1263	PTS System
Thebr_1870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thebr_1870	COG2190	(PTS) system
Thebr_1872	COG0840	transmembrane signaling receptor activity
Thebr_1874	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Thebr_1876	COG2188	Transcriptional regulator
Thebr_1880	COG1744	ABC transporter substrate-binding protein PnrA-like
Thebr_1881	COG3404	Formiminotransferase-cyclodeaminase
Thebr_1883	COG1228	amidohydrolase
Thebr_1885	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Thebr_1886	COG0840	transmembrane signaling receptor activity
Thebr_1888	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thebr_1888	COG2199	diguanylate cyclase activity
Thebr_1889	COG0531	amino acid
Thebr_1917	COG3344	reverse transcriptase
Thebr_1923	COG1363	Peptidase, m42
Thebr_1932	COG1122	ATPase activity
Thebr_1935	COG0310	cobalt ion transport
Thebr_1936	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thebr_1937	COG0113	porphobilinogen synthase activity
Thebr_1942	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Thebr_1944	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thebr_1948	COG1492	cobalamin metabolic process
Thebr_1949	COG1797	cobyrinic acid a,c-diamide synthase activity
Thebr_1950	COG1120	ATPase activity
Thebr_1951	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thebr_1952	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Thebr_1955	COG0116	Belongs to the methyltransferase superfamily
Thebr_1958	COG0822	iron-sulfur transferase activity
Thebr_1959	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thebr_1962	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thebr_1966	COG1704	LemA family
Thebr_1969	COG0714	Associated with various cellular activities
Thebr_1970	COG0735	belongs to the Fur family
Thebr_1971	COG0803	Belongs to the bacterial solute-binding protein 9 family
Thebr_1972	COG1121	(ABC) transporter
Thebr_1973	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thebr_1975	COG3250	beta-galactosidase activity
Thebr_1977	COG0444	Belongs to the ABC transporter superfamily
Thebr_1978	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thebr_1979	COG0601	transmembrane transport
Thebr_1980	COG4166	transmembrane transport
Thebr_1983	COG0730	response to heat
Thebr_1984	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thebr_1985	COG0737	Belongs to the 5'-nucleotidase family
Thebr_1986	COG0246	Mannitol dehydrogenase
Thebr_1988	COG3711	transcriptional antiterminator
Thebr_1988	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thebr_1989	COG2213	PTS system mannitol-specific
Thebr_1990	COG2723	6-phospho-beta-galactosidase activity
Thebr_1991	COG1486	melibiose metabolic process
Thebr_1992	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thebr_1994	COG3394	polysaccharide catabolic process
Thebr_1996	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thebr_1996	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thebr_1999	COG2313	pseudouridylate synthase activity
Thebr_2000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thebr_2000	COG1522	sequence-specific DNA binding
Thebr_2002	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Thebr_2003	COG0495	leucyl-tRNA aminoacylation
Thebr_2005	COG0390	transport system, permease component
Thebr_2006	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thebr_2008	COG1924	4 iron, 4 sulfur cluster binding
Thebr_2011	COG1309	transcriptional regulator
Thebr_2015	COG0640	Transcriptional regulator
Thebr_2017	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thebr_2018	COG0800	Aldolase
Thebr_2019	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thebr_2021	COG0800	Aldolase
Thebr_2022	COG1414	Transcriptional regulator
Thebr_2027	COG1979	alcohol dehydrogenase
Thebr_2028	COG4821	SIS domain
Thebr_2030	COG3037	sugar-specific permease SgaT UlaA
Thebr_2031	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thebr_2032	COG0436	Aminotransferase
Thebr_2034	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thebr_2035	COG0095	Lipoate-protein ligase
Thebr_2036	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Thebr_2037	COG0509	glycine decarboxylation via glycine cleavage system
Thebr_2038	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thebr_2039	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thebr_2040	COG1980	fructose-bisphosphate aldolase activity
Thebr_2046	COG0039	L-malate dehydrogenase activity
Thebr_2050	COG0297	glycogen (starch) synthase activity
Thebr_2055	COG0450	alkyl hydroperoxide reductase
Thebr_2057	COG0419	ATPase involved in DNA repair
Thebr_2058	COG0420	3'-5' exonuclease activity
Thebr_2059	COG1074	ATP-dependent DNA helicase activity
Thebr_2060	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Thebr_2061	COG0179	Fumarylacetoacetate (FAA) hydrolase
Thebr_2062	COG0577	efflux transmembrane transporter activity
Thebr_2062	COG1136	(ABC) transporter
Thebr_2063	COG1136	(ABC) transporter
Thebr_2064	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thebr_2065	COG0534	Mate efflux family protein
Thebr_2066	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Thebr_2068	COG0864	Transcriptional regulator
Thebr_2069	COG0310	cobalt ion transport
Thebr_2070	COG0310	cobalt ion transport
Thebr_2071	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thebr_2072	COG1122	ATPase activity
Thebr_2073	COG1918	ferrous iron import across plasma membrane
Thebr_2073	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thebr_2075	COG1522	sequence-specific DNA binding
Thebr_2076	COG0436	Aminotransferase
Thebr_2081	COG3328	transposase activity
Thebr_2083	COG1879	ABC-type sugar transport system periplasmic component
Thebr_2084	COG1172	Belongs to the binding-protein-dependent transport system permease family
Thebr_2085	COG1129	ABC transporter
Thebr_2086	COG1869	D-ribose catabolic process
Thebr_2087	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thebr_2088	COG1609	Transcriptional regulator
Thebr_2100	COG0395	ABC-type sugar transport system, permease component
Thebr_2102	COG1653	transport
Thebr_2103	COG1070	Carbohydrate kinase
Thebr_2104	COG2115	Belongs to the xylose isomerase family
Thebr_2106	COG0569	domain protein
Thebr_2107	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Thebr_2108	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thebr_2109	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thebr_2110	COG0800	Aldolase
Thebr_2111	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thebr_2112	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thebr_2113	COG3716	PTS system mannose fructose sorbose family IID component
Thebr_2115	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thebr_2116	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thebr_2116	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thebr_2117	COG2814	Major facilitator Superfamily
Thebr_2118	COG0800	Aldolase
Thebr_2119	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thebr_2120	COG4948	Mandelate Racemase Muconate Lactonizing
Thebr_2127	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thebr_2127	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thebr_2134	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thebr_2139	COG4786	Flagellar basal body rod
Thebr_2141	COG1609	Transcriptional regulator
Thebr_2143	COG2385	sporulation resulting in formation of a cellular spore
Thebr_2145	COG0686	Belongs to the AlaDH PNT family
Thebr_2146	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thebr_2150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Thebr_2151	COG0698	ribose 5-phosphate isomerase
Thebr_2152	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thebr_2153	COG0009	L-threonylcarbamoyladenylate synthase
Thebr_2156	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Thebr_2158	COG3872	metal-dependent enzyme
Thebr_2159	COG1435	thymidine kinase activity
Thebr_2160	COG0254	rRNA binding
Thebr_2161	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Thebr_2163	COG0745	RESPONSE REGULATOR receiver
Thebr_2165	COG2878	Part of a membrane complex involved in electron transport
Thebr_2165	COG1245	4Fe-4S binding domain
Thebr_2166	COG4657	Part of a membrane complex involved in electron transport
Thebr_2167	COG4660	Part of a membrane complex involved in electron transport
Thebr_2168	COG4659	FMN binding
Thebr_2169	COG4658	electron transport chain
Thebr_2170	COG4656	Part of a membrane complex involved in electron transport
Thebr_2172	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thebr_2175	COG2151	metal-sulfur cluster biosynthetic enzyme
Thebr_2175	COG0489	protein tyrosine kinase activity
Thebr_2176	COG1191	sigma factor activity
Thebr_2181	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thebr_2182	COG3583	domain protein
Thebr_2182	COG3584	3D domain protein
Thebr_2183	COG0084	hydrolase, TatD family'
Thebr_2184	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thebr_2184	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thebr_2185	COG0617	tRNA 3'-terminal CCA addition
Thebr_2186	COG0700	Nucleoside recognition
Thebr_2187	COG2715	membrane protein required for spore maturation
Thebr_2188	COG2002	toxin-antitoxin pair type II binding
Thebr_2189	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Thebr_2190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Thebr_2191	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Thebr_2192	COG2235	arginine
Thebr_2193	COG1774	PSP1 C-terminal conserved region
Thebr_2194	COG0470	DNA polymerase III
Thebr_2196	COG3870	Protein conserved in bacteria
Thebr_2197	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thebr_2198	COG1982	Orn Lys Arg decarboxylase major
Thebr_2200	COG0519	Catalyzes the synthesis of GMP from XMP
Thebr_2201	COG1940	carbohydrate kinase activity
Thebr_2203	COG2391	methyltransferase activity
Thebr_2205	COG2391	methyltransferase activity
Thebr_2206	COG0583	DNA-binding transcription factor activity
Thebr_2215	COG1573	uracil-dna glycosylase
Thebr_2217	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Thebr_2218	COG0037	tRNA processing
Thebr_2219	COG3103	Sh3 type 3 domain protein
Thebr_2219	COG0366	Alpha amylase catalytic
Thebr_2221	COG1028	Short-chain dehydrogenase reductase Sdr
Thebr_2222	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thebr_2225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thebr_2226	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thebr_2227	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thebr_2230	COG4608	Belongs to the ABC transporter superfamily
Thebr_2231	COG0444	Belongs to the ABC transporter superfamily
Thebr_2233	COG0601	transmembrane transport
Thebr_2234	COG4166	transmembrane transport
Thebr_2235	COG1609	Transcriptional regulator
Thebr_2236	COG1187	pseudouridine synthase activity
Thebr_2237	COG1028	Short-chain dehydrogenase reductase Sdr
Thebr_2241	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thebr_2242	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thebr_2243	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thebr_2244	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Thebr_2245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Thebr_2246	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thebr_2247	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thebr_2247	COG2199	diguanylate cyclase activity
Thebr_2254	COG3409	Peptidoglycan-binding domain 1 protein
Thebr_2254	COG3773	Cell wall hydrolase
Thebr_2265	COG4962	Type ii secretion system protein e
Thebr_2270	COG0739	heme binding
Thebr_2287	COG1396	sequence-specific DNA binding
Thebr_2290	COG0582	viral genome integration into host DNA
Thebr_2292	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thebr_2293	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Thebr_2294	COG0840	transmembrane signaling receptor activity
Thebr_2296	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thebr_2301	COG1394	ATPase activity, coupled to movement of substances
Thebr_2302	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Thebr_2303	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Thebr_2304	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Thebr_2305	COG1527	subunit (C
Thebr_2306	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Thebr_2307	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thebr_2308	COG1269	ATP hydrolysis coupled proton transport
Thebr_2313	COG0305	Participates in initiation and elongation during chromosome replication
Thebr_2314	COG0359	binds to the 23S rRNA
Thebr_2315	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Thebr_2318	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Thebr_2319	COG0629	single-stranded DNA binding
Thebr_2320	COG0360	Binds together with S18 to 16S ribosomal RNA
Thebr_2321	COG4481	Protein conserved in bacteria
Thebr_2322	COG0668	transmembrane transport
Thebr_2325	COG4242	Belongs to the peptidase S51 family
Thebr_2326	COG1597	lipid kinase activity
Thebr_2328	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thebr_2329	COG1475	DNA binding
Thebr_2330	COG1192	Involved in chromosome partitioning
Thebr_2333	COG0357	Ribosomal RNA small subunit methyltransferase G
Thebr_2334	COG0445	tRNA wobble uridine modification
Thebr_2335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thebr_2336	COG1847	R3H domain protein
Thebr_2337	COG0706	membrane insertase activity
Thebr_2338	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thebr_2339	COG0594	ribonuclease P activity
Thebr_2340	COG0230	Belongs to the bacterial ribosomal protein bL34 family