locus-tag	class	description
Thit_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Thit_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Thit_0003	ENOG410848D	S4 domain protein YaaA
Thit_0007	ENOG4105F1K	Glutamine amidotransferase
Thit_0010	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Thit_0011	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Thit_0012	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Thit_0013	ENOG4108ZP8	Acetolactate synthase small subunit
Thit_0015	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Thit_0017	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Thit_0018	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Thit_0019	ENOG4105C01	Dihydroxy-acid dehydratase
Thit_0020	ENOG4105C7K	acetolactate synthase
Thit_0021	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Thit_0022	ENOG4108R6K	riboflavin synthase, subunit alpha
Thit_0025	ENOG4108REF	Sporulation integral membrane protein ytvi
Thit_0028	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Thit_0029	ENOG4108KGH	TRANSCRIPTIONal
Thit_0030	ENOG4105DJZ	UPF0182 protein
Thit_0032	ENOG4108Z6B	deaminase
Thit_0033	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Thit_0034	ENOG4105C6E	dna polymerase iii
Thit_0035	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Thit_0036	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Thit_0037	ENOG4105WMR	Protein CrcB homolog
Thit_0038	ENOG4105WMR	Protein CrcB homolog
Thit_0039	ENOG4105DHT	Metal Dependent Phosphohydrolase
Thit_0043	ENOG4105CHR	reductase
Thit_0045	ENOG4105ETE	Transcriptional regulator (LacI family
Thit_0046	ENOG4108J59	Extracellular solute-binding protein, family 5
Thit_0049	ENOG4105C3U	ABC transporter
Thit_0050	ENOG4108JQ7	(ABC) transporter
Thit_0053	ENOG4105CKB	glycosidase
Thit_0054	ENOG4105CKB	glycosidase
Thit_0058	ENOG4105CPF	Cell wall formation (By similarity)
Thit_0059	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
Thit_0060	ENOG4108IG5	Transcriptional regulator
Thit_0061	ENOG4105ECB	domain protein
Thit_0064	ENOG4106DSS	Tartrate dehydratase subunit alpha
Thit_0066	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Thit_0069	ENOG4108JUB	Transcriptional regulator
Thit_0075	ENOG4105DUM	transcriptional regulator, lysR family
Thit_0076	ENOG4105CUC	YeeE YedE family protein
Thit_0078	ENOG41066VF	YeeE YedE family protein
Thit_0080	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_0081	ENOG4105DKQ	ROK family
Thit_0082	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Thit_0084	ENOG4105CXN	decarboxylase
Thit_0085	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Thit_0086	ENOG4105X0R	protein from nitrogen regulatory protein P-II
Thit_0088	ENOG4105FA2	dna polymerase iii
Thit_0089	ENOG4105MA4	psp1 domain protein
Thit_0090	ENOG4105CEU	Arginine dihydrolase
Thit_0091	ENOG41060K3	Methyltransferase
Thit_0092	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Thit_0093	ENOG41076HS	cation diffusion facilitator family transporter
Thit_0094	ENOG4105KRN	Transcriptional regulator, abrb family
Thit_0095	ENOG4108JIC	nucleoside recognition domain protein
Thit_0097	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Thit_0098	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Thit_0099	ENOG4105F8V	Hydrolase, tatD family
Thit_0100	ENOG41069ER	domain protein
Thit_0101	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Thit_0103	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_0106	ENOG4105WJF	
Thit_0107	ENOG4108WZW	RNA polymerase sigma
Thit_0108	ENOG4105D1F	ATP-binding protein
Thit_0111	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Thit_0112	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Thit_0113	ENOG4105D6A	Electron transport complex
Thit_0114	ENOG41080WF	Electron transport complex, RnfABCDGE type, G subunit
Thit_0115	ENOG4105DZB	Electron transport complex
Thit_0116	ENOG4105DGN	Electron transport complex
Thit_0117	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
Thit_0121	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Thit_0122	ENOG41082DI	50s ribosomal protein l31
Thit_0123	ENOG4107104	thymidine kinase
Thit_0124	ENOG4105CBJ	Metal-dependent enzyme
Thit_0125	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Thit_0126	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Thit_0127	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
Thit_0128	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Thit_0129	ENOG4108YZG	isomerase
Thit_0130	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Thit_0132	ENOG4105ESV	Glycosyl transferase, family 4
Thit_0133	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Thit_0136	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Thit_0137	ENOG4105DCF	alanine dehydrogenase
Thit_0141	ENOG4105MT0	Sporulation transcriptional regulator spoiiid
Thit_0142	ENOG4105DFF	Rod shape-determining protein mreb
Thit_0143	ENOG4108JQA	flagellar
Thit_0144	ENOG4105CGA	flagellar basal-body rod protein FlgG
Thit_0146	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Thit_0150	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
Thit_0153	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thit_0154	ENOG4105CTS	PTS system mannitol-specific
Thit_0155	ENOG41090UW	PTS System
Thit_0156	ENOG4105DT3	PTS system, galactitol-specific IIc component
Thit_0160	ENOG4105CXK	mandelate racemase muconate lactonizing
Thit_0161	ENOG4105C5I	Dehydrogenase
Thit_0162	ENOG4108UHU	Aldolase
Thit_0164	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thit_0165	ENOG4105YHU	PTS system
Thit_0167	ENOG4105F3R	pts system mannose fructose sorbose family iid
Thit_0168	ENOG4108IQ3	PTS system
Thit_0169	ENOG4108JQ1	Dehydrogenase
Thit_0170	ENOG4108UHU	Aldolase
Thit_0171	ENOG4105C5I	Dehydrogenase
Thit_0172	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
Thit_0173	ENOG4105CZN	Potassium uptake protein
Thit_0174	ENOG4107ZYR	domain protein
Thit_0176	ENOG4105C93	Xylose Isomerase
Thit_0177	ENOG4105CMG	Carbohydrate kinase
Thit_0180	ENOG4105D2H	Uronic isomerase
Thit_0181	ENOG4108UHU	Aldolase
Thit_0182	ENOG4105DEI	Mannitol dehydrogenase
Thit_0183	ENOG4105D7K	pfkb domain protein
Thit_0184	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
Thit_0186	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
Thit_0188	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
Thit_0191	ENOG4105I82	acetyl xylan esterase
Thit_0197	ENOG4105DRS	transport system, permease
Thit_0198	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
Thit_0201	ENOG4105D17	glycoside hydrolase, family 3 domain protein
Thit_0203	ENOG4105CE4	GlcNAc 6-P deacetylase
Thit_0204	ENOG4105CHM	Aminotransferase
Thit_0205	ENOG4108ZB6	transcriptional regulator AsnC family
Thit_0207	ENOG4105CE1	Ferrous iron transport protein b
Thit_0209	ENOG4108JJB	ABC transporter
Thit_0210	ENOG4108YZP	cobalt ABC transporter, inner membrane subunit CbiQ
Thit_0211	ENOG4105G01	cobalamin (vitamin B12) biosynthesis CbiM protein
Thit_0212	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
Thit_0213	ENOG4105MRR	Transcriptional regulator (By similarity)
Thit_0215	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Thit_0216	ENOG4105UQX	Mate efflux family protein
Thit_0217	ENOG410624X	efflux transporter, rnd family, mfp subunit
Thit_0218	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Thit_0219	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Thit_0221	ENOG4105W3S	hemerythrin-like, metal-binding protein
Thit_0222	ENOG4105ERH	Fumarylacetoacetate hydrolase
Thit_0223	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Thit_0224	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
Thit_0226	ENOG4105EYH	Exonuclease
Thit_0227	ENOG4105D3R	alkyl hydroperoxide reductase
Thit_0232	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
Thit_0233	ENOG4107QPH	glycogen) synthase
Thit_0234	ENOG4108K9K	Uncharacterised protein family (UPF0236)
Thit_0235	ENOG4107ZTW	SNARE associated Golgi
Thit_0237	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Thit_0240	ENOG4105BZ8	glutamate synthase
Thit_0243	ENOG4108HRK	Histidine kinase
Thit_0244	ENOG4108VB1	regulatoR
Thit_0245	ENOG4105DFW	ABC transporter
Thit_0246	ENOG4105DFW	ABC transporter
Thit_0248	ENOG4108HWW	ABC transporter
Thit_0249	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thit_0250	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thit_0253	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
Thit_0254	ENOG4105DF9	Lipoate-protein, ligase
Thit_0255	ENOG4107QN2	dihydrolipoyl dehydrogenase
Thit_0258	ENOG4105CHM	Aminotransferase
Thit_0261	ENOG4105CTQ	phosphohexokinase
Thit_0266	ENOG4105D2N	Aldolase
Thit_0272	ENOG4107QW4	alcohol dehydrogenase
Thit_0275	ENOG4105MKU	Transcriptional regulator
Thit_0278	ENOG4105CIZ	coA-substrate-specific enzyme activase
Thit_0280	ENOG4108T5I	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Thit_0281	ENOG4105C4B	ABC transporter, permease
Thit_0282	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
Thit_0284	ENOG4105C8T	Leucyl-tRNA synthetase
Thit_0285	ENOG4108UMN	azlc family
Thit_0289	ENOG4105DD7	kinase (PfkB family
Thit_0290	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
Thit_0291	ENOG41089WN	small, acid-soluble spore protein tlp
Thit_0293	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thit_0295	ENOG4105CK1	PTS System
Thit_0296	ENOG4105VCP	PTS System
Thit_0297	ENOG4105F8D	glycoside hydrolase family 4
Thit_0298	ENOG410667J	hydrolase
Thit_0299	ENOG4105CS2	ec 3.2.1.21
Thit_0302	ENOG4105CTS	PTS system mannitol-specific
Thit_0303	ENOG4105EMD	TRANSCRIPTIONal
Thit_0306	ENOG4105CGH	5'-nucleotidase
Thit_0307	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Thit_0308	ENOG4105EJ9	Membrane
Thit_0310	ENOG4105ETE	Transcriptional regulator (LacI family
Thit_0314	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Thit_0315	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Thit_0318	ENOG4105CNT	hydrolase family 2
Thit_0319	ENOG4105CS2	ec 3.2.1.21
Thit_0321	ENOG4105FDK	ABC transporter
Thit_0322	ENOG4105DSE	periplasmic solute binding protein
Thit_0323	ENOG4105N80	Ferric uptake regulator, Fur family
Thit_0324	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Thit_0327	ENOG4108V0P	LemA family
Thit_0328	ENOG4105DUM	transcriptional regulator, lysR family
Thit_0329	ENOG4105D5B	Sulfite reductase, subunit A
Thit_0330	ENOG4107SHJ	sulfite reductase subunit b
Thit_0331	ENOG410810Y	Sulfite reductase
Thit_0332	ENOG4105EYA	deoxyribonuclease
Thit_0335	ENOG4107YH3	SUF system FeS assembly protein, NifU family
Thit_0338	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Thit_0339	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
Thit_0340	ENOG4105EHG	Permease protein
Thit_0341	ENOG4105E0A	ABC, transporter
Thit_0342	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Thit_0347	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Thit_0348	ENOG4108YZT	Adenosylcobinamide kinase
Thit_0349	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
Thit_0351	ENOG41081F0	Precorrin-8x methylmutase
Thit_0353	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
Thit_0354	ENOG4107XSI	cobalt-precorrin-6y C15-methyltransferase
Thit_0355	ENOG4105DVK	Precorrin-2 c20-methyltransferase
Thit_0356	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
Thit_0357	ENOG4108P62	biosynthesis protein (CbiG)
Thit_0358	ENOG4105E4R	Precorrin-3B C17-methyltransferase
Thit_0359	ENOG4108JTQ	reductase
Thit_0360	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Thit_0361	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Thit_0363	ENOG4105D52	delta-aminolevulinic acid dehydratase
Thit_0364	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Thit_0367	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Thit_0368	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
Thit_0371	ENOG4108JJB	ABC transporter
Thit_0384	ENOG4108IUW	ABC transporter
Thit_0390	ENOG4105F22	Major Facilitator Superfamily
Thit_0399	ENOG4108ZXC	Two component transcriptional regulator, luxr family
Thit_0407	ENOG4105BZ1	(ABC) transporter
Thit_0409	ENOG4105C19	ABC transporter
Thit_0412	ENOG4105CN9	Peptidase m42 family protein
Thit_0413	ENOG4105CN9	Peptidase m42 family protein
Thit_0414	ENOG4105CN9	Peptidase m42 family protein
Thit_0417	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Thit_0419	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
Thit_0420	ENOG4105CCS	Glutamate formiminotransferase
Thit_0421	ENOG4105CI2	imidazolone-5-propionate hydrolase
Thit_0423	ENOG4105CG3	alpha amylase, catalytic region
Thit_0426	ENOG4107T3P	ABC, transporter
Thit_0427	ENOG4105C2F	Histidine kinase
Thit_0428	ENOG4105EQD	regulatoR
Thit_0429	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
Thit_0430	ENOG4107TFB	basic membrane
Thit_0431	ENOG4108JQ9	ABC transporter
Thit_0432	ENOG4105UIB	(ABC) transporter
Thit_0434	ENOG4105FDP	GntR family transcriptional regulator
Thit_0436	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
Thit_0438	ENOG4105C8Q	Methyl-accepting chemotaxis
Thit_0440	ENOG4105CI1	PTS System
Thit_0441	ENOG4105C5Y	PTS System
Thit_0443	ENOG4107SDT	Homocitrate synthase
Thit_0445	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Thit_0447	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Thit_0449	ENOG41066UU	tRNA (Adenine-N1-)-methyltransferase
Thit_0451	ENOG4105H67	Protein of unknown function (DUF421)
Thit_0452	ENOG410667J	hydrolase
Thit_0453	ENOG4105ETE	Transcriptional regulator (LacI family
Thit_0454	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Thit_0455	ENOG4105BZU	Histidine kinase
Thit_0460	ENOG4108RAC	Rubrerythrin
Thit_0461	ENOG4106C07	ThiamineS Protein
Thit_0462	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Thit_0464	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Thit_0465	ENOG4105C7H	Helicase, RecD TraA family
Thit_0466	ENOG4105MJ2	Competence protein
Thit_0470	ENOG4105E1Q	flagellar hook-associated protein
Thit_0471	ENOG4105DTJ	flagellar hook-associated protein
Thit_0473	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
Thit_0474	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
Thit_0475	ENOG4105I03	Flagellin
Thit_0477	ENOG41090QV	Protein of unknown function DUF115
Thit_0479	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Thit_0480	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
Thit_0481	ENOG4105D2T	synthase
Thit_0483	ENOG4105C2X	Arabinose 5-phosphate isomerase
Thit_0488	ENOG4105CAQ	asparagine synthetase
Thit_0491	ENOG4107RT6	flagellar hook-associated
Thit_0492	ENOG4105MQ3	flagellar protein FliS
Thit_0497	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thit_0498	ENOG4105CTS	PTS system mannitol-specific
Thit_0499	ENOG41090UW	PTS System
Thit_0500	ENOG4105DT3	PTS system, galactitol-specific IIc component
Thit_0501	ENOG4105DE4	1-phosphofructokinase
Thit_0502	ENOG4105FB2	class II Aldolase
Thit_0507	ENOG4105C8Q	Methyl-accepting chemotaxis
Thit_0509	ENOG4108HW3	(ABC) transporter
Thit_0510	ENOG4105E5Q	amino acid AbC transporter
Thit_0514	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Thit_0516	ENOG4108Z3G	3H domain protein
Thit_0518	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Thit_0523	ENOG4105EMD	TRANSCRIPTIONal
Thit_0524	ENOG4105DM4	PTS System
Thit_0525	ENOG4105DM4	PTS System
Thit_0526	ENOG4105DM4	PTS System
Thit_0527	ENOG4105C8I	hydrolase, family 38
Thit_0528	ENOG4108RSN	SNARE associated Golgi
Thit_0529	ENOG4105CD3	dihydroorotase
Thit_0531	ENOG4105CZQ	inner membrane transport protein YdhC
Thit_0533	ENOG4105DBV	ornithine carbamoyltransferase
Thit_0537	ENOG4105K8N	protein family UPF0079, ATPase
Thit_0538	ENOG41072GX	Peptidase M22 Glycoprotease
Thit_0540	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Thit_0542	ENOG4105C5H	ABC transporter
Thit_0543	ENOG4107R0U	MotA TolQ exbB proton channel
Thit_0544	ENOG4106VK6	Flagellar motor protein
Thit_0547	ENOG4105DY9	regulatoR
Thit_0548	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
Thit_0551	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
Thit_0552	ENOG4105BZ8	glutamate synthase
Thit_0555	ENOG4108UQV	Membrane
Thit_0557	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
Thit_0560	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_0563	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Thit_0564	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Thit_0565	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Thit_0566	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Thit_0567	ENOG4105C7N	Xanthine uracil vitamin C permease
Thit_0568	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Thit_0569	ENOG4105C8V	SAICAR synthetase
Thit_0570	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
Thit_0571	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
Thit_0572	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Thit_0574	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Thit_0575	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Thit_0576	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Thit_0577	ENOG4107QNG	Phosphoribosylglycinamide synthetase
Thit_0579	ENOG4105CH2	amidohydrolase
Thit_0581	ENOG4105CKP	Polysaccharide Biosynthesis Protein
Thit_0583	ENOG4105ETD	TRANSCRIPTIONal
Thit_0585	ENOG4105VZJ	PTS System
Thit_0586	ENOG4105CK1	PTS System
Thit_0587	ENOG4105VCP	PTS System
Thit_0588	ENOG4105KGF	protein, YerC YecD
Thit_0589	ENOG4105C4R	Atp-dependent dna helicase
Thit_0591	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Thit_0593	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Thit_0595	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Thit_0596	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Thit_0601	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Thit_0604	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
Thit_0607	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Thit_0608	ENOG4108IV0	ABC, transporter
Thit_0609	ENOG4105C0Z	ABC transporter
Thit_0610	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Thit_0611	ENOG4105C32	Amino acid ABC transporter (Permease)
Thit_0612	ENOG4105CP9	extracellular ligand-binding receptor
Thit_0615	ENOG4105BZU	Histidine kinase
Thit_0616	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Thit_0617	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Thit_0618	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Thit_0619	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Thit_0620	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Thit_0621	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Thit_0622	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
Thit_0623	ENOG41082I9	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Thit_0624	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
Thit_0625	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Thit_0626	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Thit_0627	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
Thit_0628	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Thit_0629	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Thit_0632	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
Thit_0637	ENOG4105CJW	magnesium transporter
Thit_0641	ENOG4105C8Q	Methyl-accepting chemotaxis
Thit_0644	ENOG4108TJN	glycosyl transferase group 1
Thit_0645	ENOG4107STW	synthase
Thit_0646	ENOG4105K64	Glycosyl transferase, family 2
Thit_0649	ENOG4105D5D	udp-galactopyranose mutase
Thit_0651	ENOG4107QPH	glycogen) synthase
Thit_0653	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
Thit_0654	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
Thit_0655	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
Thit_0656	ENOG4105D3Q	Sugar transferase
Thit_0661	ENOG4105C0D	helicase
Thit_0665	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
Thit_0678	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Thit_0680	ENOG4108RE9	Phosphodiesterase
Thit_0682	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
Thit_0684	ENOG41071TK	Uncharacterised protein family (UPF0150)
Thit_0701	ENOG4107SET	aldo keto reductase
Thit_0702	ENOG4107QW4	alcohol dehydrogenase
Thit_0708	ENOG4105VUF	Transcriptional regulator
Thit_0710	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thit_0715	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Thit_0716	ENOG4105HTX	biosynthesis protein
Thit_0717	ENOG4108K88	Membrane
Thit_0720	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Thit_0721	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Thit_0726	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Thit_0728	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
Thit_0730	ENOG4105BZU	Histidine kinase
Thit_0731	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Thit_0735	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Thit_0737	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Thit_0750	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_0752	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
Thit_0753	ENOG4107KJX	Transcriptional regulator
Thit_0756	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
Thit_0757	ENOG4105DRS	transport system, permease
Thit_0758	ENOG4107URF	beta-phospho-glucomutase
Thit_0760	ENOG4105ETE	Transcriptional regulator (LacI family
Thit_0762	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
Thit_0765	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
Thit_0770	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thit_0771	ENOG4105F0V	Cell wall hydrolase
Thit_0776	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Thit_0777	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Thit_0778	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Thit_0780	ENOG4105BZ1	(ABC) transporter
Thit_0781	ENOG4105BZ1	(ABC) transporter
Thit_0784	ENOG4105M3Z	response regulator
Thit_0785	ENOG4105DYB	Isoaspartyl dipeptidase
Thit_0786	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Thit_0788	ENOG4105DR5	peptidase
Thit_0795	ENOG4105D07	Signal peptide peptidase, SppA
Thit_0798	ENOG4108UIC	UPF0340 protein
Thit_0802	ENOG4108RDQ	ABC transporter
Thit_0808	ENOG4105C85	amino acid
Thit_0809	ENOG4105EMN	RNA polymerase sigma factor
Thit_0811	ENOG4105C2M	dna polymerase I
Thit_0812	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Thit_0813	ENOG4105E4C	Lytic transglycosylase catalytic
Thit_0817	ENOG4107SN7	NLP P60 protein
Thit_0818	ENOG4105CI3	gtp-binding protein typa
Thit_0819	ENOG4105E4C	Lytic transglycosylase catalytic
Thit_0823	ENOG4108R3D	Electron transport complex
Thit_0826	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
Thit_0827	ENOG4105BZU	Histidine kinase
Thit_0829	ENOG4107QIZ	NADH dehydrogenase
Thit_0830	ENOG4107QHI	-hydrogenase
Thit_0832	ENOG4108Z03	MAF-like protein
Thit_0833	ENOG4105W5Q	DNA repair protein (RadC
Thit_0834	ENOG4105DFF	Rod shape-determining protein mreb
Thit_0837	ENOG4105CJN	penicillin-binding protein
Thit_0838	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Thit_0839	ENOG4107QMS	site-determining protein
Thit_0840	ENOG41083CN	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
Thit_0841	ENOG4105CNI	cell division protein FtsW
Thit_0842	ENOG4108Z5K	methylglyoxal synthase
Thit_0843	ENOG4105DR5	peptidase
Thit_0847	ENOG4105C03	ribonuclease
Thit_0848	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
Thit_0850	ENOG41067VP	Protein of unknown function (DUF1049)
Thit_0851	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Thit_0853	ENOG4105K46	50S ribosomal protein l27
Thit_0855	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thit_0856	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Thit_0857	ENOG4108WF2	Metal Dependent Phosphohydrolase
Thit_0859	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
Thit_0863	ENOG4105CAQ	asparagine synthetase
Thit_0864	ENOG4105DZ1	carboxypeptidase
Thit_0865	ENOG4105KQC	Competence protein
Thit_0867	ENOG4108W5N	phosphatidylglycerophosphatase a
Thit_0871	ENOG41084EF	Ferredoxin
Thit_0872	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Thit_0875	ENOG4105PUK	Membrane
Thit_0876	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Thit_0877	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
Thit_0878	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
Thit_0880	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
Thit_0881	ENOG4105EPD	Oligopeptide transporter, Opt family
Thit_0885	ENOG4105CEF	Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity)
Thit_0890	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Thit_0891	ENOG4105CSA	Coproporphyrinogen iii oxidase
Thit_0893	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thit_0895	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Thit_0897	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
Thit_0898	ENOG4105VUC	UPF0237 protein
Thit_0901	ENOG4107S21	permease
Thit_0905	ENOG4105F3H	Histidine kinase
Thit_0906	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Thit_0912	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Thit_0913	ENOG4107YU2	histidine triad (hIT) protein
Thit_0914	ENOG4105VCC	30S ribosomal protein S21
Thit_0916	ENOG41068P3	sporulation protein YqfC
Thit_0918	ENOG4105C9A	Phoh family
Thit_0919	ENOG4105CTJ	Metal Dependent Phosphohydrolase
Thit_0920	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Thit_0922	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Thit_0923	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Thit_0926	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
Thit_0928	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
Thit_0929	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Thit_0931	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Thit_0939	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
Thit_0940	ENOG4108IUW	ABC transporter
Thit_0947	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
Thit_0949	ENOG4108Z0Z	intracellular protease Pfpi family
Thit_0955	ENOG4108UVJ	appr-1-p processing domain protein
Thit_0956	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Thit_0958	ENOG41066FP	Small acid-soluble spore protein I
Thit_0961	ENOG4105CNW	domain protein
Thit_0962	ENOG4108UXE	Protein tyrosine phosphatase
Thit_0965	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
Thit_0966	ENOG4107XCH	Cyclase family
Thit_0969	ENOG4105EJQ	L-serine dehydratase
Thit_0970	ENOG4105DPN	Oligoendopeptidase f
Thit_0972	ENOG4105CQC	Prephenate dehydratase
Thit_0973	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
Thit_0974	ENOG4105EVN	Prephenate dehydrogenase
Thit_0975	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Thit_0981	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Thit_0982	ENOG4105EB3	Histidine kinase
Thit_0984	ENOG41066F8	ROK family
Thit_0985	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
Thit_0987	ENOG4107QIV	Cytochrome c biogenesis protein
Thit_0988	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thit_0989	ENOG4105CXN	decarboxylase
Thit_0993	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Thit_0996	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
Thit_1000	ENOG4105C6T	cysteine synthase
Thit_1001	ENOG4105CDY	transcriptional regulatory protein
Thit_1002	ENOG4108V3W	Chemotaxis protein, CheW
Thit_1004	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Thit_1005	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Thit_1006	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Thit_1008	ENOG4105JFG	SpoIID LytB domain protein
Thit_1010	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Thit_1015	ENOG4108Z0R	Transferase
Thit_1016	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Thit_1017	ENOG4108JIS	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Thit_1019	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Thit_1021	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Thit_1022	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
Thit_1023	ENOG4105C5X	domain protein
Thit_1024	ENOG4107RBB	ABC transporter, permease
Thit_1025	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Thit_1026	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
Thit_1029	ENOG4105D5G	Transposase
Thit_1032	ENOG4105C9M	aspartyl-trna synthetase
Thit_1033	ENOG4105CUZ	uba thif-type nad fad binding protein
Thit_1034	ENOG4105VPX	protein, conserved in bacteria
Thit_1035	ENOG4105K63	Thioredoxin
Thit_1037	ENOG4106M28	alanine racemase domain protein
Thit_1040	ENOG4105C02	permease
Thit_1041	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Thit_1042	ENOG4105VBH	UPF0297 protein
Thit_1043	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Thit_1044	ENOG41085AS	UPF0473 protein
Thit_1045	ENOG4105I3K	Ferric uptake regulator, Fur family
Thit_1046	ENOG4105CN5	Metallo-Beta-Lactamase
Thit_1047	ENOG41084CE	UPF0342 protein
Thit_1049	ENOG4105HHA	aminodeoxychorismate lyase
Thit_1050	ENOG4108VQJ	O-methyltransferase
Thit_1051	ENOG4105CFP	Peptidase U32
Thit_1052	ENOG4107XRG	penicillin-binding protein
Thit_1053	ENOG4105DMD	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thit_1054	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Thit_1055	ENOG4105E2X	shikimate dehydrogenase
Thit_1056	ENOG4107QHF	type ii secretion system protein e
Thit_1057	ENOG4105CZX	twitching motility protein
Thit_1059	ENOG4108VAU	general secretion pathway protein G
Thit_1060	ENOG4106A3R	peptidase
Thit_1071	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Thit_1072	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Thit_1073	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
Thit_1074	ENOG4105DC7	peptidase M24
Thit_1075	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Thit_1077	ENOG4105CD2	stage iii sporulation protein aa
Thit_1079	ENOG4108CQH	stage III sporulation protein AC
Thit_1080	ENOG4105KQ4	Stage iii sporulation protein ad
Thit_1082	ENOG410644B	Stage III sporulation protein af
Thit_1085	ENOG4108ZSR	alkaline shock protein
Thit_1086	ENOG4105M7K	Involved in the transcription termination process (By similarity)
Thit_1087	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Thit_1088	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Thit_1089	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Thit_1092	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Thit_1093	ENOG4105DX0	Hemolysin A
Thit_1094	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Thit_1095	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
Thit_1096	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Thit_1097	ENOG4105S1Z	Stage IV sporulation protein B
Thit_1098	ENOG4107QQR	Sporulation
Thit_1107	ENOG4105MZ9	stage II sporulation protein m
Thit_1108	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Thit_1109	ENOG4105DZ1	carboxypeptidase
Thit_1111	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
Thit_1112	ENOG4105CT2	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thit_1113	ENOG41084UG	Pfam:DUF1458
Thit_1114	ENOG41090VF	Stage v sporulation protein ac
Thit_1118	ENOG4108Z4T	Peptidase M50
Thit_1119	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
Thit_1120	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Thit_1121	ENOG4105PTM	secreted protein
Thit_1123	ENOG4105KBJ	sporulation protein ytfj
Thit_1124	ENOG4105DZ1	carboxypeptidase
Thit_1126	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Thit_1127	ENOG4105FE9	pseudouridine synthase
Thit_1129	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Thit_1130	ENOG4105CYW	agmatinase
Thit_1131	ENOG4107QSA	Oxaloacetate decarboxylase
Thit_1136	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Thit_1138	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
Thit_1139	ENOG4105D82	Glutamate dehydrogenase
Thit_1141	ENOG4105CVJ	phosphoglycerate mutase
Thit_1144	ENOG4105KHN	chorismate mutase
Thit_1145	ENOG4105CAT	Cytidine monophosphate kinase
Thit_1147	ENOG4108IUH	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Thit_1149	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Thit_1150	ENOG4105BZU	Histidine kinase
Thit_1152	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Thit_1154	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Thit_1155	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
Thit_1156	ENOG4105II7	pyrroline-5-carboxylate reductase
Thit_1157	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Thit_1158	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Thit_1159	ENOG4105CXI	aluminum resistance protein
Thit_1160	ENOG4106F1P	AAA ATPase, central domain protein
Thit_1161	ENOG4105C83	adenylosuccinate lyase
Thit_1163	ENOG4105DB7	PHP domain protein
Thit_1164	ENOG4105MCT	stage V sporulation protein S
Thit_1165	ENOG4105D48	metallophosphoesterase
Thit_1166	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
Thit_1167	ENOG410902V	Modulates RecA activity (By similarity)
Thit_1168	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Thit_1169	ENOG4105CEV	competence damage-inducible protein
Thit_1170	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Thit_1171	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Thit_1172	ENOG4105CNU	cell division protein FtsK
Thit_1174	ENOG4105CVQ	ATP-dependent Clp protease, proteolytic subunit
Thit_1177	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Thit_1178	ENOG4105C1V	Peptidase, M16
Thit_1181	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Thit_1182	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Thit_1183	ENOG4105DTN	riboflavin biosynthesis protein ribF
Thit_1184	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Thit_1185	ENOG4105SFS	phosphoesterase RecJ domain protein
Thit_1186	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Thit_1187	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Thit_1189	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
Thit_1190	ENOG4105CHV	Transcription elongation factor NusA
Thit_1192	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
Thit_1194	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Thit_1195	ENOG4105DZP	Membrane-associated zinc metalloprotease
Thit_1196	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Thit_1197	ENOG4105KNE	Phosphatidate cytidylyltransferase
Thit_1198	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Thit_1200	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Thit_1201	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Thit_1202	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Thit_1206	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thit_1207	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
Thit_1209	ENOG4108V3W	Chemotaxis protein, CheW
Thit_1210	ENOG4105CBS	Chea signal transduction histidine kinase
Thit_1211	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Thit_1214	ENOG4105FZW	flagellar biosynthesis regulator FlhF
Thit_1215	ENOG4105D7B	Flagellar biosynthesis protein flha
Thit_1216	ENOG4105D00	flagellar biosynthetic protein flhB
Thit_1217	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
Thit_1218	ENOG4105VS8	Flagellar biosynthetic protein fliq
Thit_1219	ENOG4105CN7	Flagellar biosynthetic protein FliP
Thit_1221	ENOG4107YTP	response regulator receiver protein
Thit_1222	ENOG4105DD5	Flagellar motor switch protein
Thit_1223	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Thit_1224	ENOG4105X6C	Flagellar basal body-associated protein FliL
Thit_1225	ENOG41068WV	flagellar FlbD family protein
Thit_1226	ENOG4105BZE	flagellar hook protein, FlgE
Thit_1228	ENOG410822I	Flagellar hook capping protein
Thit_1236	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
Thit_1237	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
Thit_1238	ENOG4108ZC9	flagellar basal-body rod protein flgc
Thit_1239	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
Thit_1242	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
Thit_1243	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Thit_1244	ENOG4105C79	DNA protecting protein DprA
Thit_1245	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Thit_1246	ENOG4105VFF	UPF0102 protein
Thit_1247	ENOG4105C31	Tryptophanyl-tRNA synthetase
Thit_1248	ENOG4108JYZ	YitT family
Thit_1249	ENOG4105C0P	Mg chelatase subunit ChlI
Thit_1250	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
Thit_1251	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Thit_1252	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Thit_1253	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Thit_1254	ENOG4105VB6	UPF0109 protein
Thit_1255	ENOG4105K5M	30s ribosomal protein S16
Thit_1257	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
Thit_1258	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Thit_1261	ENOG4105MCT	stage V sporulation protein S
Thit_1263	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
Thit_1264	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
Thit_1265	ENOG4107QW8	radical SAM domain protein
Thit_1268	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Thit_1269	ENOG4105CBC	glutamate synthase
Thit_1270	ENOG4105EYU	Glutamine amido-transferase
Thit_1271	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Thit_1273	ENOG4108YZA	Nitrogen regulatory protein pii
Thit_1277	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Thit_1278	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Thit_1279	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Thit_1280	ENOG4105CHR	reductase
Thit_1281	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Thit_1282	ENOG4105EA8	2-Nitropropane dioxygenase
Thit_1283	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Thit_1284	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Thit_1285	ENOG4108VVV	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity)
Thit_1286	ENOG41067VY	50S ribosomal protein L32
Thit_1287	ENOG4105KNH	Nucleic acid-binding protein
Thit_1288	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Thit_1289	ENOG4108IJ2	phosphate acetyltransferase
Thit_1291	ENOG4105H20	Sporulation integral membrane protein YlbJ
Thit_1293	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Thit_1294	ENOG4106H78	methyltransferase
Thit_1297	ENOG4105EPR	degv family
Thit_1299	ENOG4105DP4	dak2 domain fusion protein ylov
Thit_1300	ENOG4108ZSR	alkaline shock protein
Thit_1304	ENOG4105DJV	ribulose-phosphate 3-epimerase
Thit_1305	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
Thit_1306	ENOG4105D9P	serine threonine protein kinase
Thit_1307	ENOG4108ZF3	Phosphatase
Thit_1308	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Thit_1309	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Thit_1312	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Thit_1313	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Thit_1315	ENOG4105C25	Primosomal protein n'
Thit_1316	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Thit_1318	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Thit_1320	ENOG4105DSJ	YicC domain protein
Thit_1321	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Thit_1322	ENOG4105C6X	Major Facilitator
Thit_1324	ENOG4105F23	Fibronectin-binding protein
Thit_1327	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
Thit_1328	ENOG4108UMI	ABC transporter, permease
Thit_1329	ENOG4105D01	(LipO)protein
Thit_1331	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Thit_1334	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Thit_1336	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
Thit_1337	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
Thit_1338	ENOG4105CD3	dihydroorotase
Thit_1339	ENOG4105CXT	aspartate transcarbamylase
Thit_1340	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Thit_1341	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
Thit_1342	ENOG4105C34	Pseudouridine synthase
Thit_1343	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Thit_1354	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
Thit_1359	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
Thit_1361	ENOG4108AEY	RNA polymerase sigma factor
Thit_1364	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_1367	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_1369	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Thit_1395	ENOG4108N0N	Phage Terminase Large Subunit
Thit_1402	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thit_1406	ENOG4108PNI	recT protein
Thit_1407	ENOG4108NF7	phage-type endonuclease
Thit_1413	ENOG4108IMY	Transcriptional regulator
Thit_1417	ENOG41067S9	phage shock protein C, PspC
Thit_1421	ENOG4105C28	cystathionine
Thit_1427	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Thit_1428	ENOG4108I0Q	anthranilate phosphoribosyltransferase
Thit_1429	ENOG4105DDQ	anthranilate synthase
Thit_1430	ENOG4105CRQ	synthase (Component I)
Thit_1432	ENOG4105C28	cystathionine
Thit_1433	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
Thit_1434	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Thit_1435	ENOG4107W7X	Aldolase
Thit_1438	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Thit_1439	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Thit_1442	ENOG4105DBK	s4 domain protein
Thit_1444	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
Thit_1445	ENOG4105DFA	alanine racemase domain protein
Thit_1447	ENOG4105KME	endoribonuclease L-psp
Thit_1448	ENOG4105C6Z	Gluconate
Thit_1449	ENOG4105BZW	Glycerate kinase
Thit_1450	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
Thit_1453	ENOG4105DXU	ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity)
Thit_1455	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Thit_1456	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Thit_1461	ENOG4105S2F	
Thit_1464	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Thit_1465	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Thit_1466	ENOG4105E2Z	phosphate ABC transporter (Permease
Thit_1467	ENOG4105C8U	phosphate abc transporter
Thit_1468	ENOG4105CVA	phosphate
Thit_1469	ENOG4105BZU	Histidine kinase
Thit_1470	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Thit_1472	ENOG4108BIK	prc-barrel domain-containing protein
Thit_1473	ENOG4105E65	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thit_1474	ENOG4105DAV	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thit_1475	ENOG4108AWX	Sporulation factor SpoIIGA 
Thit_1476	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Thit_1477	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Thit_1478	ENOG4105K67	small basic protein
Thit_1481	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Thit_1482	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Thit_1483	ENOG4105CNI	cell division protein FtsW
Thit_1485	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Thit_1486	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
Thit_1487	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Thit_1488	ENOG4105CJN	penicillin-binding protein
Thit_1495	ENOG4105C3G	gtp-binding protein
Thit_1502	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
Thit_1503	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Thit_1507	ENOG4105K4I	Scp-like extracellular
Thit_1508	ENOG4105DFM	M18 family aminopeptidase
Thit_1509	ENOG4105WH1	Two component transcriptional regulator luxr family
Thit_1512	ENOG4105EWC	Purine nucleoside phosphorylase
Thit_1513	ENOG4105C98	muts2 protein
Thit_1514	ENOG4105CFP	Peptidase U32
Thit_1516	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Thit_1517	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Thit_1518	ENOG4108RWN	rrna methyltransferase
Thit_1521	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Thit_1524	ENOG4105C22	threonyL-tRNA synthetase
Thit_1525	ENOG4108UH6	UPF0754 membrane protein
Thit_1528	ENOG4105XXY	Thioredoxin
Thit_1529	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
Thit_1530	ENOG4105VEQ	Cold shock protein
Thit_1531	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Thit_1534	ENOG41083MR	nifu domain-containing protein
Thit_1535	ENOG4108ZGC	gaf domain protein
Thit_1537	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Thit_1540	ENOG4107QSE	Dipeptidase
Thit_1541	ENOG4105DG6	mannose-6-phosphate isomerase
Thit_1542	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
Thit_1543	ENOG4105EGD	dinuclear metal center protein, YbgI family
Thit_1546	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thit_1547	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Thit_1548	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Thit_1549	ENOG4105XZU	Preprotein translocase, subunit SecG
Thit_1550	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_1551	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Thit_1552	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Thit_1553	ENOG4105CP7	Triose-phosphate isomerase
Thit_1554	ENOG4105BZA	Phosphoglycerate kinase
Thit_1557	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Thit_1558	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Thit_1559	ENOG410667J	hydrolase
Thit_1560	ENOG4105G5W	regulator Fur family
Thit_1561	ENOG41073R8	VanW family
Thit_1562	ENOG4105CSM	endonuclease III
Thit_1563	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
Thit_1565	ENOG410688J	Ferredoxin
Thit_1568	ENOG4105C22	threonyL-tRNA synthetase
Thit_1569	ENOG4105CMG	Carbohydrate kinase
Thit_1572	ENOG4105C26	Dehydrogenase
Thit_1575	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Thit_1576	ENOG4105D2N	Aldolase
Thit_1577	ENOG4105DB7	PHP domain protein
Thit_1578	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Thit_1579	ENOG4108YZG	isomerase
Thit_1580	ENOG4108IUS	Transketolase
Thit_1581	ENOG4108HHA	Transketolase
Thit_1582	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Thit_1585	ENOG4105EMS	pseudouridine synthase
Thit_1589	ENOG4105D1H	recombination factor protein RarA
Thit_1590	ENOG4108X8W	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Thit_1595	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Thit_1598	ENOG4105WEF	catalase
Thit_1599	ENOG4108UIN	ybak prolyl-trna synthetase associated region
Thit_1600	ENOG4105C3R	Methionine synthase
Thit_1602	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
Thit_1603	ENOG4107QYV	phosphohexose isomerase
Thit_1604	ENOG4108RCM	Nitroreductase
Thit_1607	ENOG4105CQS	hydrogenase expression formation protein HypD
Thit_1611	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
Thit_1613	ENOG4108HM5	NADH-ubiquinone oxidoreductase chain 49kDa
Thit_1615	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
Thit_1616	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Thit_1617	ENOG4105D65	subunit l
Thit_1620	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Thit_1622	ENOG4105E90	ABC transporter
Thit_1623	ENOG4108IJ8	ABC transporter
Thit_1625	ENOG4105UQX	Mate efflux family protein
Thit_1627	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Thit_1630	ENOG4105CTQ	phosphohexokinase
Thit_1632	ENOG4105C0B	DNA polymerase III (alpha subunit)
Thit_1634	ENOG4105KRI	phosphocarrier protein (HPr
Thit_1635	ENOG4105CIE	May be required for sporulation (By similarity)
Thit_1637	ENOG4108IUK	alpha amylase, catalytic
Thit_1641	ENOG4105EG2	ABC transporter, permease
Thit_1642	ENOG4105D56	permease protein
Thit_1643	ENOG4107FKK	extracellular solute-binding protein family 1
Thit_1648	ENOG4105D4A	Cell wall formation (By similarity)
Thit_1653	ENOG4105C59	p-type ATPase
Thit_1654	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Thit_1657	ENOG410681U	heavy metal transport detoxification protein
Thit_1658	ENOG4105DQR	SNARE associated Golgi
Thit_1659	ENOG4105VYW	UPF0251 protein
Thit_1662	ENOG4105G5W	regulator Fur family
Thit_1663	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Thit_1665	ENOG4105CE1	Ferrous iron transport protein b
Thit_1667	ENOG4105CE1	Ferrous iron transport protein b
Thit_1671	ENOG4108HWH	(ABC) transporter
Thit_1672	ENOG4105EHG	Permease protein
Thit_1673	ENOG4108HUF	Transporter
Thit_1674	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Thit_1675	ENOG4107QW8	radical SAM domain protein
Thit_1679	ENOG4105D1F	ATP-binding protein
Thit_1680	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
Thit_1686	ENOG4108JVH	Protein of unknown function DUF43
Thit_1687	ENOG4105ETE	Transcriptional regulator (LacI family
Thit_1688	ENOG4105D7K	pfkb domain protein
Thit_1689	ENOG4107R3K	hydrolase
Thit_1692	ENOG4107FKK	extracellular solute-binding protein family 1
Thit_1697	ENOG4105CJN	penicillin-binding protein
Thit_1700	ENOG4108MDK	Dehydrogenase
Thit_1701	ENOG4105CMD	Transcriptional regulator, GntR family
Thit_1702	ENOG4105CR5	Class II aldolase adducin family protein
Thit_1703	ENOG4105EF1	ribulokinase
Thit_1704	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
Thit_1706	ENOG4105CNN	ABC, transporter
Thit_1707	ENOG4105C2J	ABC transporter
Thit_1710	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
Thit_1711	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
Thit_1712	ENOG4107T3P	ABC, transporter
Thit_1713	ENOG4105C8I	hydrolase, family 38
Thit_1714	ENOG4105ID8	Transcriptional regulator, ARAC family
Thit_1715	ENOG4105CNT	hydrolase family 2
Thit_1721	ENOG4105E2R	ROK family
Thit_1722	ENOG4105CMR	udp-glucose 4-epimerase
Thit_1723	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
Thit_1724	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
Thit_1730	ENOG4108UHU	Aldolase
Thit_1731	ENOG4105UQX	Mate efflux family protein
Thit_1732	ENOG4105CHR	reductase
Thit_1733	ENOG4105F8D	glycoside hydrolase family 4
Thit_1734	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
Thit_1736	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
Thit_1737	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
Thit_1739	ENOG4105F5H	Glycosyl Hydrolase Family 88
Thit_1740	ENOG4105D7K	pfkb domain protein
Thit_1741	ENOG4105D2H	Uronic isomerase
Thit_1742	ENOG4105DEI	Mannitol dehydrogenase
Thit_1743	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
Thit_1745	ENOG4105C5I	Dehydrogenase
Thit_1748	ENOG4105C5I	Dehydrogenase
Thit_1751	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
Thit_1759	ENOG4105NBF	ammecr1 domain protein
Thit_1761	ENOG4105CEY	Amp-dependent synthetase and ligase
Thit_1764	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
Thit_1767	ENOG4105CJN	penicillin-binding protein
Thit_1770	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Thit_1771	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Thit_1772	ENOG4108N5B	2-phosphosulfolactate phosphatase
Thit_1773	ENOG4105C0H	protease
Thit_1775	ENOG4105DR5	peptidase
Thit_1776	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
Thit_1777	ENOG4105CAK	Cell division ATP-binding protein ftsE
Thit_1778	ENOG4107VHA	regulatoR
Thit_1784	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Thit_1785	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
Thit_1789	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Thit_1794	ENOG4105VDH	Dihydroxyacetone kinase
Thit_1796	ENOG4105CMT	Dihydroxyacetone kinase
Thit_1802	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
Thit_1803	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
Thit_1811	ENOG4108IGT	Dipeptidase
Thit_1812	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Thit_1813	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Thit_1816	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Thit_1817	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Thit_1818	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Thit_1819	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Thit_1820	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Thit_1821	ENOG4108IQ6	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
Thit_1830	ENOG4105CJ1	ABC, transporter
Thit_1831	ENOG4105E2V	Glycosyltransferase 36
Thit_1832	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Thit_1833	ENOG4105CK5	oxidoreductase
Thit_1834	ENOG4105DWV	Homoserine O-trans-acetylase
Thit_1836	ENOG4105D6E	homoserine dehydrogenase
Thit_1839	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Thit_1840	ENOG4105WH1	Two component transcriptional regulator luxr family
Thit_1841	ENOG4105F8J	Adenylate Guanylate cyclase
Thit_1844	ENOG4105BZU	Histidine kinase
Thit_1847	ENOG4108IUS	Transketolase
Thit_1848	ENOG4108HHA	Transketolase
Thit_1849	ENOG4108JYZ	YitT family
Thit_1854	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
Thit_1856	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Thit_1858	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Thit_1859	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Thit_1867	ENOG4105FDF	Could be involved in DNA repair (By similarity)
Thit_1868	ENOG4108J9Q	DNA ligase
Thit_1869	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
Thit_1881	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Thit_1882	ENOG41085W3	Transposase
Thit_1888	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_1906	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Thit_1908	ENOG4105E9Q	Acyl-transferase
Thit_1910	ENOG4107RE7	phosphate butyryltransferase
Thit_1916	ENOG4105CKM	Branched-chain carboxylic acid kinase
Thit_1917	ENOG4107RDP	Dehydrogenase
Thit_1918	ENOG4107RE7	phosphate butyryltransferase
Thit_1919	ENOG4105CKM	Branched-chain carboxylic acid kinase
Thit_1921	ENOG4105C8B	TIGR00159 family
Thit_1928	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_1933	ENOG4107SMJ	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
Thit_1935	ENOG4105D22	carbon starvation protein
Thit_1937	ENOG4108UJD	30S ribosomal protein S9
Thit_1938	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Thit_1939	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Thit_1940	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
Thit_1941	ENOG4108JJB	ABC transporter
Thit_1942	ENOG4108JJB	ABC transporter
Thit_1943	ENOG4108ZT0	50S ribosomal protein l17
Thit_1944	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Thit_1945	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Thit_1946	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Thit_1947	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thit_1948	ENOG41067V7	50S ribosomal protein L36
Thit_1949	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Thit_1952	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Thit_1953	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Thit_1954	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Thit_1955	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Thit_1956	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Thit_1958	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Thit_1959	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Thit_1960	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thit_1961	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Thit_1962	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Thit_1963	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Thit_1964	ENOG41082SA	50s ribosomal protein l29
Thit_1965	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Thit_1966	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Thit_1967	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Thit_1969	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Thit_1970	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thit_1973	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Thit_1974	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Thit_1975	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Thit_1976	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Thit_1977	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Thit_1978	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Thit_1979	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Thit_1980	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Thit_1981	ENOG4105XPM	ribosomal protein
Thit_1982	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Thit_1983	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Thit_1987	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Thit_1988	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Thit_1989	ENOG410683Z	Preprotein translocase SecE subunit
Thit_1990	ENOG4105WDJ	50S ribosomal protein L33
Thit_1991	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Thit_1992	ENOG4105QIV	RNA polymerase
Thit_1993	ENOG4105M0M	Tetracycline resistance protein
Thit_1994	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Thit_1996	ENOG4105C8N	cysteinyl-tRNA synthetase
Thit_1997	ENOG4105D7W	serine acetyltransferase
Thit_2001	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Thit_2003	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Thit_2004	ENOG4105CTP	PilT protein domain protein
Thit_2006	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Thit_2007	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
Thit_2009	ENOG4105EG2	ABC transporter, permease
Thit_2011	ENOG4107FKK	extracellular solute-binding protein family 1
Thit_2015	ENOG41066A3	ATP guanido phosphotransferase
Thit_2016	ENOG4108Z0C	Uvrb UvrC protein
Thit_2019	ENOG4105C6K	Malic enzyme
Thit_2021	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Thit_2022	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Thit_2024	ENOG4108YRF	PTS System
Thit_2025	ENOG4105DM4	PTS System
Thit_2026	ENOG4105DM4	PTS System
Thit_2028	ENOG4105BZU	Histidine kinase
Thit_2034	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
Thit_2035	ENOG4105PW4	Sugar fermentation stimulation protein homolog
Thit_2036	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
Thit_2037	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thit_2038	ENOG4105EEI	dihydropteroate synthase
Thit_2039	ENOG4105EUJ	GTP cyclohydrolase i
Thit_2040	ENOG4105CRK	lysyL-tRNA synthetase
Thit_2041	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Thit_2047	ENOG4105E1K	spore germination protein
Thit_2048	ENOG4105GEU	Spore germination protein
Thit_2049	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Thit_2050	ENOG4105FH5	Membrane
Thit_2051	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
Thit_2053	ENOG4107QX3	carboxylase
Thit_2055	ENOG4105CKU	formyltetrahydrofolate synthetase
Thit_2056	ENOG4105BZU	Histidine kinase
Thit_2058	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Thit_2059	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Thit_2061	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Thit_2062	ENOG4105SX7	Transporter
Thit_2066	ENOG4108T0W	nitrous oxide maturation protein NosY
Thit_2072	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
Thit_2074	ENOG4105BZU	Histidine kinase
Thit_2077	ENOG41082MP	copper ion binding protein
Thit_2078	ENOG4105C59	p-type ATPase
Thit_2082	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Thit_2087	ENOG4105C6T	cysteine synthase
Thit_2089	ENOG4105PF0	Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin
Thit_2096	ENOG4108IMY	Transcriptional regulator
Thit_2103	ENOG4105D7K	pfkb domain protein
Thit_2104	ENOG4107R3K	hydrolase
Thit_2107	ENOG4107R3K	hydrolase
Thit_2109	ENOG4105DRS	transport system, permease
Thit_2110	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
Thit_2113	ENOG4105ETE	Transcriptional regulator (LacI family
Thit_2128	ENOG4105D49	3-dehydroquinate synthase
Thit_2129	ENOG41060GV	RNA binding s1 domain protein
Thit_2135	ENOG4105VYY	sporulation protein yabp
Thit_2136	ENOG4105JFG	SpoIID LytB domain protein
Thit_2137	ENOG41082I2	s4 domain protein
Thit_2138	ENOG4105K70	DNA-binding protein
Thit_2139	ENOG4108IY2	MazG family
Thit_2141	ENOG4107SFI	Major Facilitator superfamily
Thit_2142	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Thit_2143	ENOG4108IJ0	Aspartate ammonia-lyase
Thit_2144	ENOG4105BZU	Histidine kinase
Thit_2145	ENOG4105MAX	Superoxide reductase
Thit_2149	ENOG4105EAH	synthase
Thit_2152	ENOG4105CEP	NADH dehydrogenase
Thit_2157	ENOG4108K4H	
Thit_2160	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
Thit_2165	ENOG4105CH7	arginosuccinase
Thit_2166	ENOG4105CDH	Citrulline--aspartate ligase
Thit_2168	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Thit_2169	ENOG4105C8Y	Acetylornithine aminotransferase
Thit_2170	ENOG4105CAS	nag kinase
Thit_2171	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
Thit_2178	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
Thit_2179	ENOG4105BZ8	glutamate synthase
Thit_2180	ENOG4105DCG	PHP domain protein
Thit_2181	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
Thit_2198	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
Thit_2199	ENOG4105N67	Proton-coupled thiamine transporter YuaJ
Thit_2200	ENOG4105BZ1	(ABC) transporter
Thit_2202	ENOG41067TZ	transcriptional regulator, MarR family
Thit_2203	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Thit_2204	ENOG4108EKI	Dehydrogenase
Thit_2206	ENOG4105CPC	Aldo Keto reductase
Thit_2207	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Thit_2208	ENOG4105DEF	Extracellular solute-binding protein, family 5
Thit_2211	ENOG4105C3U	ABC transporter
Thit_2212	ENOG4108JQ7	(ABC) transporter
Thit_2213	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
Thit_2214	ENOG4105C75	arginyL-tRNA synthetase
Thit_2216	ENOG4105CPF	Cell wall formation (By similarity)
Thit_2217	ENOG4105XEW	small acid-soluble spore protein
Thit_2218	ENOG4105MSI	germination protein ypeb
Thit_2220	ENOG4108ZXQ	stage ii sporulation protein r
Thit_2222	ENOG4108Q8B	Spore germination protein
Thit_2226	ENOG4105DRR	Transcriptional regulator, GntR family
Thit_2229	ENOG4105W42	Veg protein
Thit_2230	ENOG4105XFA	sporulation peptidase YabG
Thit_2231	ENOG4108M14	stage v sporulation protein t
Thit_2232	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
Thit_2233	ENOG4108JA2	transcriptioN-repair coupling factor
Thit_2236	ENOG4105C0H	protease
Thit_2237	ENOG4105BZU	Histidine kinase
Thit_2238	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Thit_2239	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Thit_2240	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Thit_2242	ENOG4105DFT	pur operon repressor
Thit_2243	ENOG4105DFU	Cell wall formation (By similarity)
Thit_2246	ENOG4105ETE	Transcriptional regulator (LacI family
Thit_2248	ENOG4105VN1	Heat shock protein
Thit_2251	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_2252	ENOG4105DM4	PTS System
Thit_2253	ENOG4105DM4	PTS System
Thit_2254	ENOG4105DE4	1-phosphofructokinase
Thit_2255	ENOG4105E98	transcriptional regulator DeoR family
Thit_2262	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Thit_2264	ENOG4105CY0	Metallo-Beta-Lactamase
Thit_2267	ENOG4105C5R	Aminotransferase
Thit_2270	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Thit_2271	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Thit_2273	ENOG41090I5	UPF0735 ACT domain-containing protein
Thit_2275	ENOG4105CUB	amino acid
Thit_2276	ENOG4105Q2H	domain protein
Thit_2277	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
Thit_2278	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
Thit_2292	ENOG4107YH3	SUF system FeS assembly protein, NifU family
Thit_2295	ENOG4105DIW	FeS assembly protein SUFB
Thit_2296	ENOG4105C3K	feS assembly ATPase SufC
Thit_2297	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Thit_2302	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Thit_2304	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
Thit_2307	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Thit_2314	ENOG4105DR5	peptidase
Thit_2316	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Thit_2317	ENOG4105CD8	aminopeptidase N
Thit_2319	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
Thit_2321	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Thit_2322	ENOG4105DZ0	fad dependent oxidoreductase
Thit_2323	ENOG4105C8Q	Methyl-accepting chemotaxis
Thit_2325	ENOG4105DPN	Oligoendopeptidase f
Thit_2327	ENOG4105C8J	)-transporter
Thit_2331	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Thit_2333	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Thit_2334	ENOG4105KXQ	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Thit_2336	ENOG4105QD4	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Thit_2340	ENOG4105C2W	permease
Thit_2342	ENOG4105D5G	Transposase
Thit_2345	ENOG41082YX	Transcriptional regulator, arsr family
Thit_2346	ENOG4105CJ1	ABC, transporter
Thit_2379	ENOG4105CDU	Replicative dna helicase
Thit_2380	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Thit_2381	ENOG4105BZR	domain protein
Thit_2384	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Thit_2385	ENOG4108UUM	single-stranded DNA-binding protein
Thit_2386	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
Thit_2387	ENOG4105VDK	protein, conserved in bacteria
Thit_2388	ENOG4105D8X	mechanosensitive ion channel
Thit_2389	ENOG4108ZDA	Sporulation protein YyaC
Thit_2391	ENOG4105DDG	Cyanophycinase
Thit_2394	ENOG4105C9B	Cysteine desulfurase
Thit_2395	ENOG4105FA0	parb-like partition protein
Thit_2396	ENOG4107QJE	Chromosome Partitioning Protein
Thit_2397	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
Thit_2399	ENOG4105EKQ	RNA-directed DNA polymerase
Thit_2401	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Thit_2402	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Thit_2403	ENOG4108Z7S	Single-stranded nucleic acid binding R3H domain-containing protein
Thit_2404	ENOG4107R4E	Membrane
Thit_2405	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Thit_2406	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Thit_2407	ENOG4105VG0	50S ribosomal protein l34