locus-tag	class	description
Thit_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thit_0002	COG0592	DNA-directed DNA polymerase activity
Thit_0003	COG2501	S4 domain
Thit_0007	COG3442	glutamine amidotransferase
Thit_0010	COG0187	DNA topoisomerase II activity
Thit_0011	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Thit_0012	COG1902	pentaerythritol trinitrate reductase activity
Thit_0013	COG0440	acetolactate synthase activity
Thit_0015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thit_0017	COG0066	3-isopropylmalate dehydratase activity
Thit_0018	COG0473	3-isopropylmalate dehydrogenase activity
Thit_0019	COG0129	dihydroxy-acid dehydratase activity
Thit_0020	COG0028	Belongs to the TPP enzyme family
Thit_0025	COG0628	permease
Thit_0028	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thit_0029	COG1316	TRANSCRIPTIONal
Thit_0030	COG1615	UPF0182 protein
Thit_0033	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thit_0033	COG2199	diguanylate cyclase activity
Thit_0034	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thit_0035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Thit_0036	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Thit_0037	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thit_0038	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Thit_0039	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thit_0043	COG1028	Short-chain dehydrogenase reductase Sdr
Thit_0044	COG1187	pseudouridine synthase activity
Thit_0045	COG1609	Transcriptional regulator
Thit_0046	COG4166	transmembrane transport
Thit_0047	COG0601	transmembrane transport
Thit_0049	COG0444	Belongs to the ABC transporter superfamily
Thit_0050	COG4608	Belongs to the ABC transporter superfamily
Thit_0053	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thit_0054	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Thit_0055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thit_0058	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thit_0059	COG1028	Short-chain dehydrogenase reductase Sdr
Thit_0061	COG1511	domain protein
Thit_0064	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Thit_0066	COG1573	uracil-dna glycosylase
Thit_0076	COG2391	methyltransferase activity
Thit_0078	COG2391	methyltransferase activity
Thit_0080	COG3344	reverse transcriptase
Thit_0081	COG1940	carbohydrate kinase activity
Thit_0082	COG0519	Catalyzes the synthesis of GMP from XMP
Thit_0084	COG1982	Orn Lys Arg decarboxylase major
Thit_0085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thit_0086	COG3870	Protein conserved in bacteria
Thit_0088	COG0470	DNA polymerase III
Thit_0089	COG1774	PSP1 C-terminal conserved region
Thit_0090	COG2235	arginine
Thit_0091	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Thit_0092	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Thit_0094	COG2002	toxin-antitoxin pair type II binding
Thit_0095	COG2715	membrane protein required for spore maturation
Thit_0096	COG0700	Nucleoside recognition
Thit_0097	COG0617	tRNA 3'-terminal CCA addition
Thit_0098	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thit_0098	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thit_0099	COG0084	hydrolase, TatD family'
Thit_0100	COG3584	3D domain protein
Thit_0100	COG3583	domain protein
Thit_0101	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thit_0103	COG3344	reverse transcriptase
Thit_0108	COG2151	metal-sulfur cluster biosynthetic enzyme
Thit_0108	COG0489	protein tyrosine kinase activity
Thit_0111	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thit_0112	COG4656	Part of a membrane complex involved in electron transport
Thit_0113	COG4658	electron transport chain
Thit_0114	COG4659	FMN binding
Thit_0115	COG4660	Part of a membrane complex involved in electron transport
Thit_0116	COG4657	Part of a membrane complex involved in electron transport
Thit_0117	COG1245	4Fe-4S binding domain
Thit_0117	COG2878	Part of a membrane complex involved in electron transport
Thit_0121	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Thit_0122	COG0254	rRNA binding
Thit_0123	COG1435	thymidine kinase activity
Thit_0124	COG3872	metal-dependent enzyme
Thit_0126	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Thit_0127	COG0428	transporter
Thit_0128	COG0009	L-threonylcarbamoyladenylate synthase
Thit_0129	COG0698	ribose 5-phosphate isomerase
Thit_0130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Thit_0132	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thit_0133	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Thit_0136	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thit_0137	COG0686	Belongs to the AlaDH PNT family
Thit_0139	COG2385	sporulation resulting in formation of a cellular spore
Thit_0141	COG1609	Transcriptional regulator
Thit_0142	COG1077	Cell shape determining protein MreB Mrl
Thit_0143	COG4786	Flagellar basal body rod
Thit_0146	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Thit_0153	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thit_0153	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thit_0154	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_0154	COG2213	PTS system mannitol-specific
Thit_0155	COG3414	Phosphotransferase system galactitol-specific IIB component
Thit_0156	COG3775	system Galactitol-specific IIC component
Thit_0160	COG4948	Mandelate Racemase Muconate Lactonizing
Thit_0161	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thit_0162	COG0800	Aldolase
Thit_0164	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thit_0164	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thit_0165	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_0167	COG3716	PTS system mannose fructose sorbose family IID component
Thit_0168	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thit_0169	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thit_0170	COG0800	Aldolase
Thit_0171	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thit_0172	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thit_0173	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Thit_0174	COG0569	domain protein
Thit_0176	COG2115	Belongs to the xylose isomerase family
Thit_0177	COG1070	Carbohydrate kinase
Thit_0178	COG0673	inositol 2-dehydrogenase activity
Thit_0180	COG1904	glucuronate isomerase
Thit_0181	COG0800	Aldolase
Thit_0182	COG0246	Mannitol dehydrogenase
Thit_0183	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thit_0185	COG4209	transmembrane transport
Thit_0186	COG0395	ABC-type sugar transport system, permease component
Thit_0191	COG3458	cephalosporin-C deacetylase activity
Thit_0197	COG0395	ABC-type sugar transport system, permease component
Thit_0201	COG1472	Belongs to the glycosyl hydrolase 3 family
Thit_0204	COG0436	Aminotransferase
Thit_0205	COG1522	sequence-specific DNA binding
Thit_0207	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thit_0207	COG1918	ferrous iron import across plasma membrane
Thit_0209	COG1122	ATPase activity
Thit_0210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thit_0211	COG0310	cobalt ion transport
Thit_0212	COG0310	cobalt ion transport
Thit_0213	COG0864	Transcriptional regulator
Thit_0215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Thit_0216	COG0534	Mate efflux family protein
Thit_0217	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thit_0218	COG1136	(ABC) transporter
Thit_0219	COG1136	(ABC) transporter
Thit_0219	COG0577	efflux transmembrane transporter activity
Thit_0221	COG2703	oxygen carrier activity
Thit_0222	COG0179	Fumarylacetoacetate (FAA) hydrolase
Thit_0223	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Thit_0224	COG1074	ATP-dependent DNA helicase activity
Thit_0225	COG0420	3'-5' exonuclease activity
Thit_0226	COG0419	ATPase involved in DNA repair
Thit_0227	COG0450	alkyl hydroperoxide reductase
Thit_0233	COG0297	glycogen (starch) synthase activity
Thit_0234	COG3464	Transposase
Thit_0235	COG0586	Pfam SNARE associated Golgi protein
Thit_0237	COG0039	L-malate dehydrogenase activity
Thit_0240	COG0493	'glutamate synthase
Thit_0240	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thit_0243	COG3275	phosphorelay sensor kinase activity
Thit_0244	COG2197	response regulator
Thit_0245	COG4213	ABC transporter substrate-binding protein
Thit_0246	COG4213	ABC transporter substrate-binding protein
Thit_0248	COG4214	carbohydrate transport
Thit_0249	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thit_0250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thit_0253	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Thit_0254	COG0095	Lipoate-protein ligase
Thit_0255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thit_0258	COG0436	Aminotransferase
Thit_0259	COG3711	transcriptional antiterminator
Thit_0259	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_0261	COG0205	6-phosphofructokinase activity
Thit_0266	COG0191	fructose-bisphosphate aldolase activity
Thit_0272	COG1979	alcohol dehydrogenase
Thit_0275	COG1309	transcriptional regulator
Thit_0278	COG1924	4 iron, 4 sulfur cluster binding
Thit_0280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thit_0281	COG0390	transport system, permease component
Thit_0282	COG0823	Involved in the tonB-independent uptake of proteins
Thit_0284	COG0495	leucyl-tRNA aminoacylation
Thit_0285	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Thit_0289	COG1522	sequence-specific DNA binding
Thit_0289	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thit_0290	COG2313	pseudouridylate synthase activity
Thit_0293	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thit_0293	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thit_0295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thit_0296	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thit_0297	COG1486	melibiose metabolic process
Thit_0298	COG0561	phosphatase activity
Thit_0299	COG2723	6-phospho-beta-galactosidase activity
Thit_0302	COG2213	PTS system mannitol-specific
Thit_0303	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_0303	COG3711	transcriptional antiterminator
Thit_0306	COG0737	Belongs to the 5'-nucleotidase family
Thit_0307	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Thit_0308	COG0730	response to heat
Thit_0313	COG4166	transmembrane transport
Thit_0314	COG0601	transmembrane transport
Thit_0315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thit_0316	COG0444	Belongs to the ABC transporter superfamily
Thit_0318	COG3250	beta-galactosidase activity
Thit_0320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Thit_0321	COG1121	(ABC) transporter
Thit_0322	COG0803	Belongs to the bacterial solute-binding protein 9 family
Thit_0323	COG0735	belongs to the Fur family
Thit_0324	COG0714	Associated with various cellular activities
Thit_0327	COG1704	LemA family
Thit_0328	COG0583	DNA-binding transcription factor activity
Thit_0331	COG2221	Nitrite and sulphite reductase 4Fe-4S
Thit_0332	COG0084	hydrolase, TatD family'
Thit_0335	COG0822	iron-sulfur transferase activity
Thit_0338	COG0116	Belongs to the methyltransferase superfamily
Thit_0339	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Thit_0340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thit_0341	COG1120	ATPase activity
Thit_0342	COG1797	cobyrinic acid a,c-diamide synthase activity
Thit_0347	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thit_0349	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Thit_0356	COG2875	Belongs to the precorrin methyltransferase family
Thit_0360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Thit_0361	COG0181	hydroxymethylbilane synthase activity
Thit_0363	COG0113	porphobilinogen synthase activity
Thit_0364	COG1648	precorrin-2 dehydrogenase activity
Thit_0364	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Thit_0367	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thit_0368	COG0310	cobalt ion transport
Thit_0371	COG1122	ATPase activity
Thit_0384	COG4555	ABC transporter
Thit_0390	COG2814	Major facilitator Superfamily
Thit_0397	COG1131	(ABC) transporter
Thit_0399	COG4566	intracellular signal transduction
Thit_0407	COG1132	(ABC) transporter
Thit_0409	COG1136	(ABC) transporter
Thit_0412	COG1363	Peptidase, m42
Thit_0417	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thit_0417	COG2199	diguanylate cyclase activity
Thit_0419	COG0840	transmembrane signaling receptor activity
Thit_0421	COG1228	amidohydrolase
Thit_0426	COG1653	transport
Thit_0427	COG2972	Histidine kinase
Thit_0428	COG4753	response regulator
Thit_0428	COG2207	Transcriptional regulator
Thit_0429	COG3404	Formiminotransferase-cyclodeaminase
Thit_0430	COG1744	ABC transporter substrate-binding protein PnrA-like
Thit_0434	COG2188	Transcriptional regulator
Thit_0436	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Thit_0438	COG0840	transmembrane signaling receptor activity
Thit_0440	COG1263	PTS System
Thit_0440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Thit_0440	COG2190	(PTS) system
Thit_0441	COG2190	(PTS) system
Thit_0442	COG3711	transcriptional antiterminator
Thit_0443	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thit_0445	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Thit_0447	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Thit_0449	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Thit_0451	COG2323	membrane
Thit_0452	COG0561	phosphatase activity
Thit_0453	COG1609	Transcriptional regulator
Thit_0454	COG0745	RESPONSE REGULATOR receiver
Thit_0455	COG5002	protein histidine kinase activity
Thit_0460	COG1592	Rubrerythrin
Thit_0461	COG2104	thiamine diphosphate biosynthetic process
Thit_0462	COG0037	tRNA processing
Thit_0463	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Thit_0464	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Thit_0465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Thit_0466	COG1040	competence protein
Thit_0470	COG4786	Flagellar basal body rod
Thit_0470	COG1256	bacterial-type flagellum assembly
Thit_0471	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thit_0473	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Thit_0474	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Thit_0475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Thit_0477	COG2604	Protein of unknown function DUF115
Thit_0478	COG1086	Polysaccharide biosynthesis protein
Thit_0479	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Thit_0480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Thit_0481	COG2089	acid synthase
Thit_0483	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Thit_0483	COG0517	IMP dehydrogenase activity
Thit_0488	COG0367	asparagine synthase
Thit_0491	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Thit_0492	COG1516	flagellar protein fliS
Thit_0497	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thit_0497	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thit_0498	COG2213	PTS system mannitol-specific
Thit_0498	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_0499	COG3414	Phosphotransferase system galactitol-specific IIB component
Thit_0500	COG3775	system Galactitol-specific IIC component
Thit_0501	COG1105	Belongs to the carbohydrate kinase PfkB family
Thit_0502	COG0235	Class ii aldolase
Thit_0507	COG0840	transmembrane signaling receptor activity
Thit_0509	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thit_0510	COG0765	amino acid transport
Thit_0516	COG1827	regulation of RNA biosynthetic process
Thit_0518	COG0653	protein targeting
Thit_0520	COG2183	response to ionizing radiation
Thit_0523	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_0523	COG3711	transcriptional antiterminator
Thit_0524	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_0524	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_0524	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_0525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_0525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_0525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_0526	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_0527	COG0383	alpha-mannosidase activity
Thit_0528	COG0398	Pfam SNARE associated Golgi protein
Thit_0531	COG2814	Major facilitator Superfamily
Thit_0533	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thit_0537	COG0802	atpase or kinase
Thit_0538	COG1214	PFAM Peptidase M22, glycoprotease
Thit_0540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thit_0542	COG0488	(ABC) transporter
Thit_0543	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Thit_0547	COG3279	Response regulator of the LytR AlgR family
Thit_0548	COG3290	protein histidine kinase activity
Thit_0552	COG0493	'glutamate synthase
Thit_0555	COG1811	Na channel or pump
Thit_0557	COG1404	Belongs to the peptidase S8 family
Thit_0560	COG3344	reverse transcriptase
Thit_0563	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thit_0564	COG0459	protein refolding
Thit_0565	COG0516	GMP reductase activity
Thit_0565	COG0517	IMP dehydrogenase activity
Thit_0566	COG0519	Catalyzes the synthesis of GMP from XMP
Thit_0566	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thit_0567	COG2252	PERMEase
Thit_0568	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thit_0569	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thit_0570	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thit_0571	COG0047	phosphoribosylformylglycinamidine synthase activity
Thit_0572	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thit_0573	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Thit_0574	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Thit_0575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thit_0576	COG0138	bifunctional purine biosynthesis protein purh
Thit_0577	COG0151	Belongs to the GarS family
Thit_0579	COG1473	amidohydrolase
Thit_0581	COG2244	polysaccharide biosynthetic process
Thit_0583	COG3711	transcriptional antiterminator
Thit_0585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thit_0586	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Thit_0587	COG1447	Phosphotransferase system cellobiose-specific component IIA
Thit_0588	COG4496	protein, YerC YecD
Thit_0589	COG0210	DNA helicase
Thit_0591	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thit_0593	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Thit_0595	COG2247	cell wall binding repeat
Thit_0595	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thit_0596	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thit_0600	COG0351	phosphomethylpyrimidine kinase
Thit_0601	COG0352	thiamine-phosphate diphosphorylase activity
Thit_0604	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Thit_0607	COG0704	Plays a role in the regulation of phosphate uptake
Thit_0608	COG0410	ABC transporter
Thit_0611	COG0559	Belongs to the binding-protein-dependent transport system permease family
Thit_0615	COG3706	GGDEF domain
Thit_0617	COG0544	peptidyl-prolyl cis-trans isomerase activity
Thit_0618	COG0740	serine-type endopeptidase activity
Thit_0619	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Thit_0620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Thit_0621	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Thit_0622	COG0356	it plays a direct role in the translocation of protons across the membrane
Thit_0623	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thit_0624	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Thit_0625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thit_0626	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Thit_0627	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Thit_0628	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Thit_0629	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Thit_0631	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Thit_0631	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thit_0632	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Thit_0633	COG1116	anion transmembrane transporter activity
Thit_0637	COG2239	Acts as a magnesium transporter
Thit_0641	COG3290	protein histidine kinase activity
Thit_0641	COG0840	transmembrane signaling receptor activity
Thit_0645	COG0438	transferase activity, transferring glycosyl groups
Thit_0646	COG1215	transferase activity, transferring glycosyl groups
Thit_0649	COG0562	UDP-galactopyranose mutase
Thit_0651	COG0297	glycogen (starch) synthase activity
Thit_0654	COG1091	dTDP-4-dehydrorhamnose reductase activity
Thit_0656	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Thit_0661	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thit_0665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thit_0678	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Thit_0680	COG0622	Phosphoesterase
Thit_0682	COG1914	H( )-stimulated, divalent metal cation uptake system
Thit_0684	COG1598	PFAM Uncharacterised protein family UPF0150
Thit_0701	COG0667	Aldo Keto reductase
Thit_0702	COG1979	alcohol dehydrogenase
Thit_0703	COG0656	L-ascorbic acid biosynthetic process
Thit_0708	COG0789	Transcriptional regulator
Thit_0710	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Thit_0713	COG0250	Participates in transcription elongation, termination and antitermination
Thit_0715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thit_0716	COG3944	biosynthesis protein
Thit_0717	COG3949	Membrane
Thit_0719	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thit_0720	COG0105	UTP biosynthetic process
Thit_0721	COG2814	Major facilitator Superfamily
Thit_0726	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thit_0727	COG1606	tRNA processing
Thit_0728	COG1691	(AIR) carboxylase
Thit_0730	COG5002	protein histidine kinase activity
Thit_0731	COG0745	RESPONSE REGULATOR receiver
Thit_0735	COG0525	valine-tRNA ligase activity
Thit_0737	COG0285	dihydrofolate synthase activity
Thit_0750	COG3344	reverse transcriptase
Thit_0752	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thit_0753	COG1609	Transcriptional regulator
Thit_0756	COG1175	transmembrane transport
Thit_0757	COG0395	ABC-type sugar transport system, permease component
Thit_0758	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thit_0762	COG0395	ABC-type sugar transport system, permease component
Thit_0765	COG1404	Belongs to the peptidase S8 family
Thit_0770	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Thit_0770	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Thit_0771	COG3773	Cell wall hydrolase
Thit_0771	COG3409	Peptidoglycan-binding domain 1 protein
Thit_0776	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Thit_0777	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thit_0778	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Thit_0780	COG1132	(ABC) transporter
Thit_0781	COG1132	(ABC) transporter
Thit_0785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Thit_0786	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Thit_0788	COG0739	heme binding
Thit_0795	COG0616	signal peptide processing
Thit_0798	COG4475	Protein of unknown function (DUF436)
Thit_0802	COG1131	(ABC) transporter
Thit_0808	COG1113	amino acid transport
Thit_0809	COG1595	DNA-templated transcription, initiation
Thit_0811	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thit_0811	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Thit_0812	COG0237	dephospho-CoA kinase activity
Thit_0813	COG0741	lytic transglycosylase activity
Thit_0817	COG0791	NLP P60 protein
Thit_0819	COG0741	lytic transglycosylase activity
Thit_0823	COG2878	Part of a membrane complex involved in electron transport
Thit_0827	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Thit_0827	COG4191	Histidine kinase
Thit_0832	COG0424	maF-like protein
Thit_0833	COG2003	Belongs to the UPF0758 family
Thit_0834	COG1077	Cell shape determining protein MreB Mrl
Thit_0837	COG0768	penicillin binding
Thit_0838	COG0850	regulation of cytokinetic process
Thit_0839	COG2894	cell division
Thit_0840	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Thit_0841	COG0772	Belongs to the SEDS family
Thit_0842	COG1803	Methylglyoxal synthase
Thit_0843	COG0739	heme binding
Thit_0844	COG1994	Peptidase M50
Thit_0844	COG0517	IMP dehydrogenase activity
Thit_0847	COG1530	ribonuclease E activity
Thit_0848	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Thit_0850	COG5416	Lipopolysaccharide assembly protein A domain
Thit_0851	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Thit_0853	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Thit_0855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thit_0856	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Thit_0857	COG1713	HD superfamily hydrolase involved in NAD metabolism
Thit_0858	COG1316	TRANSCRIPTIONal
Thit_0859	COG0799	negative regulation of ribosome biogenesis
Thit_0863	COG0367	asparagine synthase
Thit_0864	COG1686	Belongs to the peptidase S11 family
Thit_0865	COG1596	polysaccharide export
Thit_0865	COG1555	photosystem II stabilization
Thit_0867	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Thit_0872	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Thit_0875	COG4720	Psort location CytoplasmicMembrane, score
Thit_0877	COG1234	tRNA 3'-trailer cleavage
Thit_0878	COG2333	competence protein COMEC
Thit_0878	COG0658	competence protein
Thit_0880	COG0268	Binds directly to 16S ribosomal RNA
Thit_0881	COG1297	OPT oligopeptide transporter protein
Thit_0885	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Thit_0890	COG0481	GTPase activity
Thit_0891	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Thit_0893	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thit_0895	COG0484	heat shock protein binding
Thit_0897	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Thit_0898	COG3830	Belongs to the UPF0237 family
Thit_0901	COG0701	Predicted permease
Thit_0904	COG0745	RESPONSE REGULATOR receiver
Thit_0905	COG2770	Histidine kinase
Thit_0905	COG2205	protein histidine kinase activity
Thit_0906	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Thit_0910	COG2246	polysaccharide biosynthetic process
Thit_0912	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thit_0913	COG0537	adenosine 5'-monophosphoramidase activity
Thit_0914	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Thit_0918	COG1702	phosphate starvation-inducible protein PhoH
Thit_0919	COG1480	7TM receptor with intracellular HD hydrolase
Thit_0920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Thit_0921	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Thit_0922	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Thit_0923	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Thit_0926	COG0423	glycine-tRNA ligase activity
Thit_0928	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Thit_0929	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thit_0929	COG0574	Belongs to the PEP-utilizing enzyme family
Thit_0931	COG0557	exoribonuclease II activity
Thit_0939	COG0602	queuosine metabolic process
Thit_0940	COG4555	ABC transporter
Thit_0947	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Thit_0949	COG0693	protein deglycase activity
Thit_0955	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Thit_0956	COG1968	undecaprenyl-diphosphatase activity
Thit_0959	COG3069	C4-dicarboxylate transmembrane transporter activity
Thit_0961	COG0426	domain, Protein
Thit_0962	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Thit_0964	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Thit_0965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Thit_0966	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Thit_0969	COG1760	l-serine dehydratase
Thit_0970	COG1164	Oligoendopeptidase f
Thit_0972	COG0077	Prephenate dehydratase
Thit_0972	COG1605	Chorismate mutase
Thit_0973	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thit_0974	COG0287	Prephenate dehydrogenase
Thit_0975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thit_0977	COG3773	Cell wall hydrolase
Thit_0977	COG3409	Peptidoglycan-binding domain 1 protein
Thit_0978	COG2119	membrane
Thit_0981	COG0745	RESPONSE REGULATOR receiver
Thit_0982	COG2205	protein histidine kinase activity
Thit_0984	COG1940	carbohydrate kinase activity
Thit_0985	COG0363	glucosamine-6-phosphate deaminase activity
Thit_0987	COG0785	Cytochrome C biogenesis protein
Thit_0988	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thit_0989	COG1982	Orn Lys Arg decarboxylase major
Thit_0993	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Thit_0996	COG1739	Uncharacterized protein family UPF0029
Thit_1000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thit_1001	COG0217	transcriptional regulatory protein
Thit_1002	COG0835	chemotaxis
Thit_1004	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Thit_1005	COG0632	four-way junction helicase activity
Thit_1006	COG2255	four-way junction helicase activity
Thit_1008	COG2385	sporulation resulting in formation of a cellular spore
Thit_1008	COG2247	cell wall binding repeat
Thit_1010	COG0343	queuine tRNA-ribosyltransferase activity
Thit_1015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Thit_1016	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thit_1017	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Thit_1019	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Thit_1019	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Thit_1021	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Thit_1022	COG1490	D-aminoacyl-tRNA deacylase activity
Thit_1023	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thit_1024	COG0577	efflux transmembrane transporter activity
Thit_1025	COG1136	(ABC) transporter
Thit_1026	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Thit_1029	COG3328	transposase activity
Thit_1032	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Thit_1033	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Thit_1034	COG1937	Protein conserved in bacteria
Thit_1035	COG3118	belongs to the thioredoxin family
Thit_1037	COG3457	Alanine racemase
Thit_1038	COG1959	2 iron, 2 sulfur cluster binding
Thit_1040	COG0628	permease
Thit_1041	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thit_1042	COG4472	Bacterial protein of unknown function (DUF965)
Thit_1043	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Thit_1044	COG3906	Belongs to the UPF0473 family
Thit_1045	COG0735	belongs to the Fur family
Thit_1046	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Thit_1047	COG3679	Belongs to the UPF0342 family
Thit_1049	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Thit_1052	COG0768	penicillin binding
Thit_1053	COG1191	sigma factor activity
Thit_1055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Thit_1060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Thit_1071	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thit_1072	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Thit_1073	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Thit_1074	COG0006	proline dipeptidase activity
Thit_1075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Thit_1077	COG3854	ATPases associated with a variety of cellular activities
Thit_1085	COG1302	Protein conserved in bacteria
Thit_1086	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thit_1087	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thit_1088	COG1570	exodeoxyribonuclease VII activity
Thit_1089	COG1722	exodeoxyribonuclease VII activity
Thit_1092	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Thit_1093	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Thit_1094	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thit_1095	COG1438	arginine binding
Thit_1096	COG0497	DNA recombination
Thit_1097	COG0750	zinc metalloprotease
Thit_1106	COG1379	DNA repair
Thit_1107	COG1300	Membrane
Thit_1108	COG4974	Belongs to the 'phage' integrase family
Thit_1109	COG1686	Belongs to the peptidase S11 family
Thit_1110	COG1366	Belongs to the anti-sigma-factor antagonist family
Thit_1111	COG2172	sigma factor antagonist activity
Thit_1113	COG3360	Dodecin
Thit_1118	COG1994	Peptidase M50
Thit_1119	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Thit_1120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Thit_1121	COG4086	secreted protein
Thit_1123	COG3874	Sporulation protein YtfJ
Thit_1124	COG1686	Belongs to the peptidase S11 family
Thit_1126	COG0445	tRNA wobble uridine modification
Thit_1127	COG1187	pseudouridine synthase activity
Thit_1129	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thit_1130	COG0010	Belongs to the arginase family
Thit_1132	COG1388	LysM domain
Thit_1132	COG1705	Flagellar rod assembly protein muramidase FlgJ
Thit_1136	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Thit_1141	COG0406	alpha-ribazole phosphatase activity
Thit_1145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Thit_1147	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Thit_1149	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thit_1150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Thit_1152	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Thit_1154	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Thit_1155	COG1923	regulation of RNA biosynthetic process
Thit_1156	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Thit_1157	COG0328	RNA-DNA hybrid ribonuclease activity
Thit_1158	COG4974	Belongs to the 'phage' integrase family
Thit_1159	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Thit_1160	COG0464	growth
Thit_1161	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Thit_1163	COG0613	PHP domain protein
Thit_1164	COG2359	stage V sporulation protein S
Thit_1165	COG1692	metallophosphoesterase
Thit_1166	COG1418	mRNA catabolic process
Thit_1167	COG2137	regulation of response to DNA damage stimulus
Thit_1168	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Thit_1169	COG1546	Belongs to the CinA family
Thit_1169	COG1058	Belongs to the CinA family
Thit_1170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Thit_1171	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thit_1172	COG1674	ftsk spoiiie
Thit_1174	COG0740	serine-type endopeptidase activity
Thit_1175	COG0527	aspartate kinase activity
Thit_1177	COG0756	dUTP diphosphatase activity
Thit_1178	COG0612	Peptidase, M16
Thit_1180	COG0726	polysaccharide deacetylase
Thit_1181	COG1185	polyribonucleotide nucleotidyltransferase activity
Thit_1182	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Thit_1183	COG0196	riboflavin kinase activity
Thit_1184	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Thit_1185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Thit_1186	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Thit_1187	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Thit_1189	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Thit_1190	COG0195	Participates in both transcription termination and antitermination
Thit_1192	COG2176	DNA-directed DNA polymerase activity
Thit_1194	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Thit_1195	COG0750	zinc metalloprotease
Thit_1196	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Thit_1197	COG4589	Belongs to the CDS family
Thit_1198	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Thit_1200	COG0233	cytoplasmic translational termination
Thit_1201	COG0528	UMP kinase activity
Thit_1202	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Thit_1206	COG1191	sigma factor activity
Thit_1207	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Thit_1208	COG1776	CheC inhibitor of MCP methylation
Thit_1209	COG0835	chemotaxis
Thit_1210	COG0643	Histidine kinase
Thit_1210	COG2198	Histidine kinase
Thit_1211	COG2201	protein-glutamate methylesterase activity
Thit_1213	COG0455	bacterial-type flagellum organization
Thit_1214	COG1419	protein localization to endoplasmic reticulum
Thit_1215	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thit_1216	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Thit_1217	COG1684	flagellar biosynthetic protein fliR
Thit_1218	COG1987	bacterial-type flagellum assembly
Thit_1219	COG1338	Plays a role in the flagellum-specific transport system
Thit_1221	COG2201	protein-glutamate methylesterase activity
Thit_1222	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thit_1222	COG1776	CheC inhibitor of MCP methylation
Thit_1223	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Thit_1224	COG1580	Controls the rotational direction of flagella during chemotaxis
Thit_1225	COG1582	Flagellar protein (FlbD)
Thit_1228	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Thit_1232	COG1157	protein secretion by the type III secretion system
Thit_1236	COG1766	The M ring may be actively involved in energy transduction
Thit_1237	COG1677	Flagellar hook-basal body complex protein FliE
Thit_1239	COG1815	bacterial-type flagellum-dependent cell motility
Thit_1242	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Thit_1243	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thit_1244	COG0758	DNA mediated transformation
Thit_1245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thit_1246	COG0792	nuclease activity
Thit_1247	COG0180	Tryptophanyl-tRNA synthetase
Thit_1248	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thit_1249	COG0606	chelatase, subunit chli
Thit_1251	COG0335	large ribosomal subunit rRNA binding
Thit_1252	COG0336	Belongs to the RNA methyltransferase TrmD family
Thit_1253	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Thit_1254	COG1837	Belongs to the UPF0109 family
Thit_1255	COG0228	four-way junction DNA binding
Thit_1256	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thit_1257	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Thit_1258	COG0552	protein localization to endoplasmic reticulum
Thit_1261	COG2359	stage V sporulation protein S
Thit_1263	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Thit_1264	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Thit_1265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thit_1268	COG0437	4 iron, 4 sulfur cluster binding
Thit_1269	COG0069	glutamate synthase activity
Thit_1269	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Thit_1270	COG0067	glutamate synthase
Thit_1271	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thit_1273	COG0347	Belongs to the P(II) protein family
Thit_1274	COG0004	ammonium transporteR
Thit_1277	COG0571	ribonuclease III activity
Thit_1278	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Thit_1279	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Thit_1280	COG1028	Short-chain dehydrogenase reductase Sdr
Thit_1281	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Thit_1282	COG2070	2-Nitropropane dioxygenase
Thit_1283	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thit_1284	COG0416	fatty acid biosynthetic process
Thit_1285	COG2030	dehydratase
Thit_1286	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Thit_1287	COG1399	metal-binding, possibly nucleic acid-binding protein
Thit_1288	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Thit_1289	COG0280	phosphate acetyltransferase
Thit_1291	COG3314	Sporulation integral membrane protein YlbJ
Thit_1293	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Thit_1294	COG0742	ribosomal rna small subunit methyltransferase
Thit_1297	COG1307	EDD domain protein, DegV family
Thit_1298	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thit_1299	COG1461	Dihydroxyacetone kinase
Thit_1300	COG1302	Protein conserved in bacteria
Thit_1304	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thit_1305	COG1162	GTPase activity
Thit_1306	COG2815	serine threonine protein kinase
Thit_1306	COG0515	serine threonine protein kinase
Thit_1307	COG0631	protein serine/threonine phosphatase activity
Thit_1308	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Thit_1309	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Thit_1309	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thit_1310	COG2738	Putative neutral zinc metallopeptidase
Thit_1312	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Thit_1313	COG0242	peptide deformylase activity
Thit_1315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Thit_1316	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Thit_1318	COG0194	GDP metabolic process
Thit_1320	COG1561	YicC-like family, N-terminal region
Thit_1321	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Thit_1322	COG2814	Major facilitator Superfamily
Thit_1327	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Thit_1328	COG2011	ABC-type metal ion transport system permease component
Thit_1329	COG1464	Belongs to the NlpA lipoprotein family
Thit_1331	COG0037	tRNA processing
Thit_1334	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thit_1336	COG0543	2 iron, 2 sulfur cluster binding
Thit_1337	COG0284	orotidine-5'-phosphate decarboxylase activity
Thit_1338	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thit_1339	COG0540	Belongs to the ATCase OTCase family
Thit_1340	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Thit_1341	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Thit_1342	COG0564	pseudouridine synthase activity
Thit_1343	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Thit_1354	COG1337	RAMP superfamily
Thit_1359	COG1970	mechanosensitive ion channel activity
Thit_1361	COG1595	DNA-templated transcription, initiation
Thit_1364	COG3344	reverse transcriptase
Thit_1367	COG3344	reverse transcriptase
Thit_1369	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thit_1395	COG1783	phage Terminase large subunit
Thit_1402	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thit_1404	COG1484	DNA-dependent DNA replication
Thit_1406	COG3723	Recombinational DNA repair protein, rece pathway
Thit_1407	COG5377	YqaJ viral recombinase family
Thit_1413	COG1396	sequence-specific DNA binding
Thit_1417	COG1983	PspC domain protein
Thit_1421	COG0626	cystathionine gamma-synthase activity
Thit_1427	COG0134	indole-3-glycerol-phosphate synthase activity
Thit_1428	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thit_1429	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thit_1429	COG0512	Glutamine amidotransferase of anthranilate synthase
Thit_1433	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Thit_1434	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Thit_1435	COG0235	Class ii aldolase
Thit_1438	COG0402	S-adenosylhomocysteine deaminase activity
Thit_1439	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thit_1441	COG3599	regulation of cell shape
Thit_1442	COG2302	S4 RNA-binding domain
Thit_1444	COG1799	cell septum assembly
Thit_1445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Thit_1448	COG2610	gluconate transmembrane transporter activity
Thit_1449	COG1929	Belongs to the glycerate kinase type-1 family
Thit_1450	COG3835	regulator
Thit_1453	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Thit_1455	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thit_1456	COG1160	GTP binding
Thit_1464	COG0704	Plays a role in the regulation of phosphate uptake
Thit_1465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Thit_1466	COG0581	inorganic phosphate transmembrane transporter activity
Thit_1467	COG0573	inorganic phosphate transmembrane transporter activity
Thit_1468	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Thit_1469	COG5002	protein histidine kinase activity
Thit_1470	COG0745	RESPONSE REGULATOR receiver
Thit_1472	COG1873	PFAM PRC-barrel domain
Thit_1473	COG1191	sigma factor activity
Thit_1474	COG1191	sigma factor activity
Thit_1476	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thit_1477	COG0849	cell division
Thit_1478	COG3856	small basic protein
Thit_1481	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thit_1482	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Thit_1483	COG0772	Belongs to the SEDS family
Thit_1485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Thit_1486	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Thit_1487	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Thit_1488	COG0768	penicillin binding
Thit_1492	COG0612	Peptidase, M16
Thit_1493	COG0612	Peptidase, M16
Thit_1495	COG0012	GTP binding
Thit_1502	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Thit_1503	COG0321	lipoyl(octanoyl) transferase activity
Thit_1504	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thit_1507	COG2340	Cysteine-rich secretory protein family
Thit_1508	COG1362	aminopeptidase activity
Thit_1509	COG2197	response regulator
Thit_1512	COG1683	Conserved Protein
Thit_1513	COG1193	negative regulation of DNA recombination
Thit_1514	COG0826	peptidase U32
Thit_1516	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thit_1516	COG0072	phenylalanine-tRNA ligase activity
Thit_1517	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Thit_1518	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thit_1521	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Thit_1524	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thit_1525	COG4399	Belongs to the UPF0754 family
Thit_1528	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Thit_1529	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Thit_1530	COG1278	Cold shock
Thit_1531	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Thit_1534	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Thit_1535	COG1956	GAF domain-containing protein
Thit_1537	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Thit_1540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Thit_1541	COG1482	cell wall glycoprotein biosynthetic process
Thit_1542	COG0813	purine-nucleoside phosphorylase activity
Thit_1543	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Thit_1546	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Thit_1547	COG0358	DNA primase activity
Thit_1548	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Thit_1549	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thit_1550	COG3344	reverse transcriptase
Thit_1551	COG0148	phosphopyruvate hydratase activity
Thit_1553	COG0149	triose-phosphate isomerase activity
Thit_1554	COG0126	phosphoglycerate kinase activity
Thit_1556	COG2390	Transcriptional regulator
Thit_1557	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Thit_1558	COG1254	Belongs to the acylphosphatase family
Thit_1559	COG0561	phosphatase activity
Thit_1561	COG2720	vancomycin resistance protein
Thit_1562	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thit_1563	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Thit_1568	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thit_1569	COG1070	Carbohydrate kinase
Thit_1572	COG1012	belongs to the aldehyde dehydrogenase family
Thit_1575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thit_1577	COG0613	PHP domain protein
Thit_1578	COG0546	phosphoglycolate phosphatase activity
Thit_1579	COG0698	ribose 5-phosphate isomerase
Thit_1580	COG3958	Transketolase
Thit_1581	COG3959	Transketolase, thiamine diphosphate binding domain
Thit_1582	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Thit_1585	COG0564	pseudouridine synthase activity
Thit_1589	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Thit_1590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Thit_1595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thit_1598	COG3546	catalase activity
Thit_1599	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Thit_1600	COG1410	methionine synthase
Thit_1600	COG0646	methionine synthase
Thit_1601	COG0646	methionine synthase
Thit_1601	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Thit_1602	COG0058	SHG alpha-glucan phosphorylase activity
Thit_1603	COG0166	Belongs to the GPI family
Thit_1604	COG0778	Nitroreductase
Thit_1607	COG0409	Hydrogenase expression formation protein
Thit_1608	COG0298	carbon dioxide binding
Thit_1609	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Thit_1611	COG0375	protein maturation
Thit_1615	COG3260	NADH ubiquinone oxidoreductase 20
Thit_1616	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Thit_1617	COG2111	Na H antiporter
Thit_1617	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thit_1620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thit_1622	COG1174	glycine betaine transport
Thit_1623	COG1125	glycine betaine transport
Thit_1623	COG0517	IMP dehydrogenase activity
Thit_1624	COG3273	potassium ion transport
Thit_1624	COG0471	metal ion transport
Thit_1625	COG0534	Mate efflux family protein
Thit_1627	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thit_1630	COG0205	6-phosphofructokinase activity
Thit_1633	COG4109	DRTGG domain
Thit_1634	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_1635	COG1481	regulation of sporulation
Thit_1637	COG0366	Alpha amylase catalytic
Thit_1638	COG1426	Protein conserved in bacteria
Thit_1641	COG3833	ABC-type maltose transport systems, permease component
Thit_1642	COG1175	transmembrane transport
Thit_1643	COG2182	Extracellular solute-binding protein
Thit_1648	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Thit_1653	COG2217	Heavy metal translocating P-type atpase
Thit_1654	COG0482	sulfurtransferase activity
Thit_1657	COG2608	mercury ion transmembrane transporter activity
Thit_1658	COG0586	Pfam SNARE associated Golgi protein
Thit_1659	COG1342	Belongs to the UPF0251 family
Thit_1663	COG2199	diguanylate cyclase activity
Thit_1663	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Thit_1665	COG1918	ferrous iron import across plasma membrane
Thit_1665	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thit_1667	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Thit_1667	COG1918	ferrous iron import across plasma membrane
Thit_1671	COG1120	ATPase activity
Thit_1672	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thit_1673	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Thit_1674	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thit_1675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Thit_1679	COG0489	protein tyrosine kinase activity
Thit_1680	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Thit_1687	COG1609	Transcriptional regulator
Thit_1688	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thit_1689	COG1621	beta-fructofuranosidase activity
Thit_1692	COG2182	Extracellular solute-binding protein
Thit_1697	COG0768	penicillin binding
Thit_1700	COG0371	Dehydrogenase
Thit_1701	COG1609	Transcriptional regulator
Thit_1702	COG0235	Class ii aldolase
Thit_1703	COG1069	ribulokinase activity
Thit_1704	COG2160	L-arabinose isomerase activity
Thit_1706	COG1172	Belongs to the binding-protein-dependent transport system permease family
Thit_1707	COG1129	ABC transporter
Thit_1710	COG0395	ABC-type sugar transport system, permease component
Thit_1711	COG1175	transmembrane transport
Thit_1712	COG1653	transport
Thit_1713	COG0383	alpha-mannosidase activity
Thit_1714	COG4977	sequence-specific DNA binding
Thit_1714	COG1917	Cupin 2, conserved barrel domain protein
Thit_1715	COG3250	beta-galactosidase activity
Thit_1721	COG1940	carbohydrate kinase activity
Thit_1722	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thit_1723	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Thit_1724	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Thit_1730	COG0800	Aldolase
Thit_1731	COG0534	Mate efflux family protein
Thit_1732	COG1028	Short-chain dehydrogenase reductase Sdr
Thit_1733	COG1486	melibiose metabolic process
Thit_1734	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Thit_1736	COG0395	ABC-type sugar transport system, permease component
Thit_1737	COG1175	transmembrane transport
Thit_1739	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Thit_1740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thit_1741	COG1904	glucuronate isomerase
Thit_1742	COG0246	Mannitol dehydrogenase
Thit_1743	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Thit_1744	COG1070	Carbohydrate kinase
Thit_1745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thit_1747	COG1349	DNA-binding transcription factor activity
Thit_1748	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thit_1751	COG0673	inositol 2-dehydrogenase activity
Thit_1759	COG3885	ferrous iron binding
Thit_1759	COG2078	PFAM AMMECR1 domain protein
Thit_1761	COG0318	PFAM AMP-dependent synthetase and ligase
Thit_1762	COG1940	carbohydrate kinase activity
Thit_1764	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Thit_1767	COG0768	penicillin binding
Thit_1771	COG0556	nucleotide-excision repair
Thit_1772	COG2045	Belongs to the ComB family
Thit_1774	COG0793	Belongs to the peptidase S41A family
Thit_1774	COG3409	Peptidoglycan-binding domain 1 protein
Thit_1775	COG0739	heme binding
Thit_1776	COG2177	Part of the ABC transporter FtsEX involved in
Thit_1777	COG2884	Cell division ATP-binding protein ftsE
Thit_1778	COG3835	regulator
Thit_1779	COG3842	ATPase activity
Thit_1784	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Thit_1785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Thit_1789	COG0849	cell division
Thit_1794	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_1794	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thit_1794	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Thit_1796	COG2376	Dihydroxyacetone kinase
Thit_1799	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thit_1802	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thit_1803	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Thit_1807	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thit_1809	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Thit_1810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Thit_1812	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thit_1813	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Thit_1813	COG0140	phosphoribosyl-ATP diphosphatase activity
Thit_1816	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Thit_1817	COG0131	Imidazoleglycerol-phosphate dehydratase
Thit_1818	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Thit_1819	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Thit_1820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Thit_1821	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Thit_1830	COG1131	(ABC) transporter
Thit_1831	COG3459	Glycosyltransferase 36 associated
Thit_1832	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Thit_1832	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Thit_1833	COG0673	inositol 2-dehydrogenase activity
Thit_1834	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Thit_1836	COG0460	homoserine dehydrogenase
Thit_1840	COG2197	response regulator
Thit_1844	COG0745	RESPONSE REGULATOR receiver
Thit_1844	COG2205	protein histidine kinase activity
Thit_1844	COG4191	Histidine kinase
Thit_1847	COG3958	Transketolase
Thit_1848	COG3959	Transketolase, thiamine diphosphate binding domain
Thit_1849	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Thit_1854	COG2337	Toxic component of a toxin-antitoxin (TA) module
Thit_1856	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Thit_1858	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thit_1858	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thit_1859	COG0736	holo-[acyl-carrier-protein] synthase activity
Thit_1867	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Thit_1868	COG1793	dna ligase
Thit_1869	COG0432	Pfam Uncharacterised protein family UPF0047
Thit_1872	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Thit_1880	COG1396	sequence-specific DNA binding
Thit_1881	COG4974	Belongs to the 'phage' integrase family
Thit_1882	COG3547	Transposase (IS116 IS110 IS902 family)
Thit_1888	COG3344	reverse transcriptase
Thit_1906	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Thit_1910	COG0280	phosphate acetyltransferase
Thit_1916	COG3426	butyrate kinase activity
Thit_1917	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Thit_1918	COG0280	phosphate acetyltransferase
Thit_1919	COG3426	butyrate kinase activity
Thit_1921	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Thit_1927	COG1705	Flagellar rod assembly protein muramidase FlgJ
Thit_1927	COG1388	LysM domain
Thit_1928	COG3344	reverse transcriptase
Thit_1933	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Thit_1935	COG1966	Carbon starvation protein
Thit_1937	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thit_1938	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thit_1939	COG0101	tRNA pseudouridine synthase activity
Thit_1940	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Thit_1941	COG1122	ATPase activity
Thit_1942	COG1122	ATPase activity
Thit_1943	COG0203	ribosomal protein L17
Thit_1944	COG0202	RNA polymerase activity
Thit_1945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thit_1946	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thit_1947	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thit_1948	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Thit_1949	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Thit_1952	COG0563	adenylate kinase activity
Thit_1953	COG0201	protein transport
Thit_1954	COG0200	Binds to the 23S rRNA
Thit_1955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thit_1956	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Thit_1958	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thit_1959	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Thit_1960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thit_1961	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Thit_1962	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thit_1963	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Thit_1964	COG0255	Belongs to the universal ribosomal protein uL29 family
Thit_1965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Thit_1966	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thit_1967	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thit_1969	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thit_1970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thit_1973	COG0089	rRNA binding
Thit_1974	COG0088	Forms part of the polypeptide exit tunnel
Thit_1975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thit_1976	COG0051	transcription antitermination factor activity, RNA binding
Thit_1977	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thit_1978	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thit_1979	COG0049	tRNA binding
Thit_1980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Thit_1981	COG1358	cellular component organization or biogenesis
Thit_1982	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thit_1983	COG0085	RNA polymerase activity
Thit_1987	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thit_1988	COG0250	Participates in transcription elongation, termination and antitermination
Thit_1989	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Thit_1990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Thit_1991	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thit_1993	COG3688	RNA-binding protein containing a PIN domain
Thit_1994	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Thit_1996	COG0215	cysteine-tRNA ligase activity
Thit_1997	COG1045	serine acetyltransferase
Thit_2001	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Thit_2003	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Thit_2004	COG4956	integral membrane protein (PIN domain superfamily)
Thit_2006	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Thit_2007	COG1914	H( )-stimulated, divalent metal cation uptake system
Thit_2009	COG3833	ABC-type maltose transport systems, permease component
Thit_2010	COG1175	transmembrane transport
Thit_2011	COG2182	Extracellular solute-binding protein
Thit_2014	COG0542	response to heat
Thit_2015	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Thit_2016	COG3880	PFAM UvrB UvrC protein
Thit_2019	COG0281	malic enzyme
Thit_2021	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thit_2022	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thit_2024	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_2025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_2025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_2025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_2026	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_2026	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_2026	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_2027	COG3711	transcriptional antiterminator
Thit_2027	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_2028	COG3706	GGDEF domain
Thit_2028	COG0745	RESPONSE REGULATOR receiver
Thit_2032	COG4224	UPF0291 protein
Thit_2034	COG0823	Involved in the tonB-independent uptake of proteins
Thit_2034	COG4946	Tricorn protease homolog
Thit_2034	COG1506	peptidase
Thit_2035	COG1489	DNA binding
Thit_2036	COG0720	synthase
Thit_2037	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Thit_2038	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thit_2039	COG0302	gtp cyclohydrolase
Thit_2040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Thit_2041	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Thit_2042	COG5322	oxidoreductase activity
Thit_2042	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thit_2047	COG0697	spore germination
Thit_2048	COG0531	amino acid
Thit_2049	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Thit_2050	COG4684	Psort location CytoplasmicMembrane, score
Thit_2051	COG4770	biotin carboxylase activity
Thit_2053	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Thit_2055	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Thit_2056	COG3852	Histidine kinase
Thit_2059	COG0037	tRNA processing
Thit_2060	COG2208	phosphoserine phosphatase activity
Thit_2061	COG2226	methyltransferase
Thit_2062	COG0697	spore germination
Thit_2065	COG1131	(ABC) transporter
Thit_2072	COG0860	N-Acetylmuramoyl-L-alanine amidase
Thit_2077	COG2608	mercury ion transmembrane transporter activity
Thit_2078	COG2217	Heavy metal translocating P-type atpase
Thit_2082	COG0745	RESPONSE REGULATOR receiver
Thit_2089	COG1598	PFAM Uncharacterised protein family UPF0150
Thit_2096	COG1396	sequence-specific DNA binding
Thit_2103	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thit_2104	COG1621	beta-fructofuranosidase activity
Thit_2107	COG1621	beta-fructofuranosidase activity
Thit_2109	COG0395	ABC-type sugar transport system, permease component
Thit_2110	COG1175	transmembrane transport
Thit_2113	COG1609	Transcriptional regulator
Thit_2128	COG0248	Ppx GppA phosphatase
Thit_2128	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Thit_2129	COG1098	S1 RNA binding domain
Thit_2136	COG2385	sporulation resulting in formation of a cellular spore
Thit_2137	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Thit_2138	COG0776	regulation of translation
Thit_2139	COG3956	TIGRFAM MazG family protein
Thit_2141	COG2814	Major facilitator Superfamily
Thit_2142	COG1160	GTP binding
Thit_2143	COG1027	Aspartate ammonia-lyase
Thit_2144	COG5002	protein histidine kinase activity
Thit_2145	COG2033	superoxide reductase activity
Thit_2149	COG0142	geranyltranstransferase activity
Thit_2152	COG1252	NADH dehydrogenase
Thit_2160	COG1725	Transcriptional regulator
Thit_2165	COG0165	Argininosuccinate lyase
Thit_2166	COG0137	argininosuccinate synthase activity
Thit_2168	COG0505	Belongs to the CarA family
Thit_2169	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Thit_2170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Thit_2171	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Thit_2179	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Thit_2179	COG0493	'glutamate synthase
Thit_2180	COG1796	DNA polymerase
Thit_2180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thit_2198	COG0671	phosphoesterase, PA-phosphatase related
Thit_2199	COG3859	Proton-coupled thiamine transporter YuaJ
Thit_2200	COG1132	(ABC) transporter
Thit_2202	COG1846	Transcriptional regulator
Thit_2203	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Thit_2204	COG1012	belongs to the aldehyde dehydrogenase family
Thit_2204	COG1454	alcohol dehydrogenase
Thit_2206	COG0667	Aldo Keto reductase
Thit_2207	COG0167	dihydroorotate dehydrogenase activity
Thit_2208	COG0747	negative chemotaxis
Thit_2209	COG0601	transmembrane transport
Thit_2211	COG0444	Belongs to the ABC transporter superfamily
Thit_2212	COG4608	Belongs to the ABC transporter superfamily
Thit_2213	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Thit_2214	COG0018	arginyl-trna synthetase
Thit_2216	COG1181	Belongs to the D-alanine--D-alanine ligase family
Thit_2218	COG2959	enzyme of heme biosynthesis
Thit_2219	COG3409	Peptidoglycan-binding domain 1 protein
Thit_2219	COG3773	Cell wall hydrolase
Thit_2222	COG0531	amino acid
Thit_2223	COG0697	spore germination
Thit_2226	COG1802	Transcriptional regulator
Thit_2228	COG1388	LysM domain
Thit_2229	COG4466	Protein conserved in bacteria
Thit_2231	COG2002	toxin-antitoxin pair type II binding
Thit_2232	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thit_2233	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Thit_2236	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thit_2237	COG5002	protein histidine kinase activity
Thit_2238	COG0745	RESPONSE REGULATOR receiver
Thit_2239	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Thit_2240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Thit_2242	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Thit_2243	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Thit_2248	COG0071	Belongs to the small heat shock protein (HSP20) family
Thit_2251	COG3344	reverse transcriptase
Thit_2253	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Thit_2253	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_2253	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Thit_2255	COG1349	DNA-binding transcription factor activity
Thit_2256	COG2373	Large extracellular alpha-helical protein
Thit_2262	COG0504	CTP synthase activity
Thit_2264	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thit_2266	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thit_2267	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Thit_2269	COG0793	Belongs to the peptidase S41A family
Thit_2269	COG3409	Peptidoglycan-binding domain 1 protein
Thit_2270	COG0083	homoserine kinase activity
Thit_2271	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Thit_2272	COG0460	homoserine dehydrogenase
Thit_2273	COG4492	Belongs to the UPF0735 family
Thit_2275	COG0531	amino acid
Thit_2276	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Thit_2277	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thit_2278	COG1518	maintenance of DNA repeat elements
Thit_2292	COG0822	iron-sulfur transferase activity
Thit_2293	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thit_2295	COG0719	Fe-S assembly protein
Thit_2296	COG0396	ATPase activity
Thit_2297	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Thit_2302	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Thit_2304	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Thit_2306	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Thit_2307	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Thit_2314	COG0739	heme binding
Thit_2316	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Thit_2317	COG0308	aminopeptidase N
Thit_2319	COG2333	competence protein COMEC
Thit_2319	COG0658	competence protein
Thit_2321	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thit_2322	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Thit_2323	COG0840	transmembrane signaling receptor activity
Thit_2325	COG1164	Oligoendopeptidase f
Thit_2327	COG0733	neurotransmitter:sodium symporter activity
Thit_2331	COG1394	ATPase activity, coupled to movement of substances
Thit_2333	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Thit_2334	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Thit_2335	COG1527	subunit (C
Thit_2336	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Thit_2337	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Thit_2338	COG1269	ATP hydrolysis coupled proton transport
Thit_2342	COG3328	transposase activity
Thit_2345	COG0640	Transcriptional regulator
Thit_2346	COG1131	(ABC) transporter
Thit_2379	COG0305	Participates in initiation and elongation during chromosome replication
Thit_2380	COG0359	binds to the 23S rRNA
Thit_2381	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Thit_2384	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Thit_2385	COG0629	single-stranded DNA binding
Thit_2386	COG0360	Binds together with S18 to 16S ribosomal RNA
Thit_2387	COG4481	Protein conserved in bacteria
Thit_2388	COG0668	transmembrane transport
Thit_2394	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thit_2395	COG1475	DNA binding
Thit_2396	COG1192	Involved in chromosome partitioning
Thit_2399	COG3344	reverse transcriptase
Thit_2401	COG0445	tRNA wobble uridine modification
Thit_2402	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Thit_2403	COG1847	R3H domain protein
Thit_2404	COG0706	membrane insertase activity
Thit_2405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Thit_2406	COG0594	ribonuclease P activity
Thit_2407	COG0230	Belongs to the bacterial ribosomal protein bL34 family