locus-tag	class	description
TKV_c00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TKV_c00020	COG0592	DNA-directed DNA polymerase activity
TKV_c00060	COG3442	glutamine amidotransferase
TKV_c00080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TKV_c00090	COG0187	DNA topoisomerase II activity
TKV_c00100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TKV_c00110	COG0511	ligase activity, forming carbon-carbon bonds
TKV_c00120	COG0439	Biotin carboxylase
TKV_c00130	COG0440	acetolactate synthase activity
TKV_c00150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TKV_c00170	COG0066	3-isopropylmalate dehydratase activity
TKV_c00180	COG0473	3-isopropylmalate dehydrogenase activity
TKV_c00190	COG0129	dihydroxy-acid dehydratase activity
TKV_c00200	COG0028	Belongs to the TPP enzyme family
TKV_c00240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TKV_c00250	COG0628	permease
TKV_c00270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TKV_c00300	COG1316	TRANSCRIPTIONal
TKV_c00310	COG1615	UPF0182 protein
TKV_c00370	COG1785	Belongs to the alkaline phosphatase family
TKV_c00460	COG3464	Transposase
TKV_c00470	COG2199	diguanylate cyclase activity
TKV_c00470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TKV_c00480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TKV_c00490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TKV_c00500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TKV_c00510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TKV_c00520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TKV_c00530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TKV_c00610	COG1028	Short-chain dehydrogenase reductase Sdr
TKV_c00620	COG1187	pseudouridine synthase activity
TKV_c00630	COG1609	Transcriptional regulator
TKV_c00640	COG1653	transport
TKV_c00650	COG1175	transmembrane transport
TKV_c00660	COG0395	ABC-type sugar transport system, permease component
TKV_c00680	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TKV_c00690	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TKV_c00700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TKV_c00750	COG1511	domain protein
TKV_c00760	COG0037	tRNA processing
TKV_c00770	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TKV_c00790	COG1573	uracil-dna glycosylase
TKV_c00850	COG0425	Belongs to the sulfur carrier protein TusA family
TKV_c00860	COG2391	methyltransferase activity
TKV_c00900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TKV_c00920	COG1940	carbohydrate kinase activity
TKV_c00930	COG0519	Catalyzes the synthesis of GMP from XMP
TKV_c00950	COG1982	Orn Lys Arg decarboxylase major
TKV_c00960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TKV_c00970	COG3870	Protein conserved in bacteria
TKV_c00990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TKV_c01000	COG1774	PSP1 C-terminal conserved region
TKV_c01020	COG0730	response to heat
TKV_c01040	COG2235	arginine
TKV_c01050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TKV_c01060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TKV_c01070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TKV_c01080	COG2002	toxin-antitoxin pair type II binding
TKV_c01090	COG2715	membrane protein required for spore maturation
TKV_c01100	COG0700	Nucleoside recognition
TKV_c01110	COG0617	tRNA 3'-terminal CCA addition
TKV_c01120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TKV_c01120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TKV_c01130	COG0084	hydrolase, TatD family'
TKV_c01140	COG3584	3D domain protein
TKV_c01140	COG3583	domain protein
TKV_c01150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TKV_c01190	COG1191	sigma factor activity
TKV_c01200	COG0489	protein tyrosine kinase activity
TKV_c01200	COG2151	metal-sulfur cluster biosynthetic enzyme
TKV_c01220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TKV_c01230	COG2111	Na H antiporter
TKV_c01230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TKV_c01240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TKV_c01250	COG3260	NADH ubiquinone oxidoreductase 20
TKV_c01260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TKV_c01270	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_c01330	COG0375	protein maturation
TKV_c01340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TKV_c01360	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TKV_c01370	COG0298	carbon dioxide binding
TKV_c01380	COG0409	Hydrogenase expression formation protein
TKV_c01420	COG0745	RESPONSE REGULATOR receiver
TKV_c01440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TKV_c01450	COG0254	rRNA binding
TKV_c01460	COG1435	thymidine kinase activity
TKV_c01470	COG3872	metal-dependent enzyme
TKV_c01480	COG2890	protein-(glutamine-N5) methyltransferase activity
TKV_c01510	COG0009	L-threonylcarbamoyladenylate synthase
TKV_c01520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TKV_c01530	COG0698	ribose 5-phosphate isomerase
TKV_c01540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TKV_c01560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TKV_c01570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TKV_c01600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TKV_c01680	COG2385	sporulation resulting in formation of a cellular spore
TKV_c01700	COG1609	Transcriptional regulator
TKV_c01720	COG4786	Flagellar basal body rod
TKV_c01750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TKV_c01840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TKV_c01850	COG0569	domain protein
TKV_c01880	COG1172	Belongs to the binding-protein-dependent transport system permease family
TKV_c01890	COG1879	ABC-type sugar transport system periplasmic component
TKV_c01910	COG0348	domain, Protein
TKV_c01930	COG0436	Aminotransferase
TKV_c01940	COG1522	sequence-specific DNA binding
TKV_c01960	COG1918	ferrous iron import across plasma membrane
TKV_c01960	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TKV_c01970	COG1122	ATPase activity
TKV_c01980	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TKV_c01990	COG0310	cobalt ion transport
TKV_c02000	COG0310	cobalt ion transport
TKV_c02010	COG0864	Transcriptional regulator
TKV_c02030	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TKV_c02060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TKV_c02080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TKV_c02090	COG1136	(ABC) transporter
TKV_c02100	COG1136	(ABC) transporter
TKV_c02100	COG0577	efflux transmembrane transporter activity
TKV_c02120	COG0179	Fumarylacetoacetate (FAA) hydrolase
TKV_c02150	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
TKV_c02160	COG1074	ATP-dependent DNA helicase activity
TKV_c02170	COG0420	3'-5' exonuclease activity
TKV_c02180	COG0419	ATPase involved in DNA repair
TKV_c02200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TKV_c02210	COG0450	alkyl hydroperoxide reductase
TKV_c02260	COG0297	glycogen (starch) synthase activity
TKV_c02270	COG0586	Pfam SNARE associated Golgi protein
TKV_c02310	COG0039	L-malate dehydrogenase activity
TKV_c02380	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TKV_c02390	COG1980	fructose-bisphosphate aldolase activity
TKV_c02400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TKV_c02410	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TKV_c02430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TKV_c02440	COG3464	Transposase
TKV_c02450	COG0095	Lipoate-protein ligase
TKV_c02470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TKV_c02490	COG0436	Aminotransferase
TKV_c02600	COG1979	alcohol dehydrogenase
TKV_c02640	COG1309	transcriptional regulator
TKV_c02670	COG1924	4 iron, 4 sulfur cluster binding
TKV_c02680	COG1230	cation diffusion facilitator family transporter
TKV_c02700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TKV_c02710	COG0390	transport system, permease component
TKV_c02720	COG0823	Involved in the tonB-independent uptake of proteins
TKV_c02740	COG0495	leucyl-tRNA aminoacylation
TKV_c02750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TKV_c02770	COG1522	sequence-specific DNA binding
TKV_c02770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TKV_c02780	COG2313	pseudouridylate synthase activity
TKV_c02800	COG0306	phosphate transporter
TKV_c02820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TKV_c02820	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TKV_c02830	COG2213	PTS system mannitol-specific
TKV_c02840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_c02840	COG3711	transcriptional antiterminator
TKV_c02870	COG0737	Belongs to the 5'-nucleotidase family
TKV_c02880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TKV_c02900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TKV_c02910	COG1121	(ABC) transporter
TKV_c02920	COG0803	Belongs to the bacterial solute-binding protein 9 family
TKV_c02930	COG0735	belongs to the Fur family
TKV_c02940	COG1704	LemA family
TKV_c02950	COG0583	DNA-binding transcription factor activity
TKV_c02980	COG2221	Nitrite and sulphite reductase 4Fe-4S
TKV_c03000	COG0351	phosphomethylpyrimidine kinase
TKV_c03010	COG0352	thiamine-phosphate diphosphorylase activity
TKV_c03090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TKV_c03100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TKV_c03110	COG1120	ATPase activity
TKV_c03120	COG1797	cobyrinic acid a,c-diamide synthase activity
TKV_c03130	COG1492	cobalamin metabolic process
TKV_c03170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TKV_c03180	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TKV_c03260	COG2875	Belongs to the precorrin methyltransferase family
TKV_c03300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TKV_c03330	COG0113	porphobilinogen synthase activity
TKV_c03340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TKV_c03340	COG1648	precorrin-2 dehydrogenase activity
TKV_c03370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TKV_c03380	COG0310	cobalt ion transport
TKV_c03410	COG1122	ATPase activity
TKV_c03470	COG4555	ABC transporter
TKV_c03540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TKV_c03560	COG1131	(ABC) transporter
TKV_c03720	COG1131	(ABC) transporter
TKV_c03740	COG2771	luxR family
TKV_c03850	COG1131	(ABC) transporter
TKV_c03860	COG3464	Transposase
TKV_c03900	COG0577	efflux transmembrane transporter activity
TKV_c03930	COG1132	(ABC) transporter
TKV_c03950	COG0602	queuosine metabolic process
TKV_c03990	COG4555	ABC transporter
TKV_c04000	COG1668	transmembrane transport
TKV_c04080	COG3588	fructose-bisphosphate aldolase
TKV_c04100	COG0577	efflux transmembrane transporter activity
TKV_c04100	COG1136	(ABC) transporter
TKV_c04290	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TKV_c04350	COG2199	diguanylate cyclase activity
TKV_c04350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TKV_c04380	COG0840	transmembrane signaling receptor activity
TKV_c04390	COG1228	amidohydrolase
TKV_c04400	COG1744	ABC transporter substrate-binding protein PnrA-like
TKV_c04440	COG2188	Transcriptional regulator
TKV_c04460	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TKV_c04500	COG1263	PTS System
TKV_c04500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TKV_c04510	COG2190	(PTS) system
TKV_c04520	COG3711	transcriptional antiterminator
TKV_c04530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TKV_c04550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TKV_c04570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TKV_c04590	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TKV_c04610	COG2323	membrane
TKV_c04620	COG0561	phosphatase activity
TKV_c04640	COG1609	Transcriptional regulator
TKV_c04650	COG0745	RESPONSE REGULATOR receiver
TKV_c04660	COG5002	protein histidine kinase activity
TKV_c04740	COG1592	Rubrerythrin
TKV_c04750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TKV_c04760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TKV_c04770	COG1040	competence protein
TKV_c04810	COG1256	bacterial-type flagellum assembly
TKV_c04810	COG4786	Flagellar basal body rod
TKV_c04820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TKV_c04840	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TKV_c04850	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TKV_c04900	COG0367	asparagine synthase
TKV_c04930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TKV_c04940	COG1516	flagellar protein fliS
TKV_c04960	COG0840	transmembrane signaling receptor activity
TKV_c04980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKV_c04990	COG0765	amino acid transport
TKV_c05050	COG1827	regulation of RNA biosynthetic process
TKV_c05070	COG0653	protein targeting
TKV_c05080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TKV_c05090	COG2183	response to ionizing radiation
TKV_c05160	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TKV_c05170	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TKV_c05170	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TKV_c05180	COG1131	(ABC) transporter
TKV_c05200	COG0842	Transport permease protein
TKV_c05230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TKV_c05240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TKV_c05260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TKV_c05270	COG1120	ATPase activity
TKV_c05280	COG0398	Pfam SNARE associated Golgi protein
TKV_c05310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TKV_c05320	COG0549	Belongs to the carbamate kinase family
TKV_c05330	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TKV_c05340	COG0802	atpase or kinase
TKV_c05350	COG1214	PFAM Peptidase M22, glycoprotease
TKV_c05370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TKV_c05390	COG0488	(ABC) transporter
TKV_c05400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TKV_c05440	COG3279	Response regulator of the LytR AlgR family
TKV_c05450	COG3290	protein histidine kinase activity
TKV_c05520	COG0424	maF-like protein
TKV_c05530	COG1811	Na channel or pump
TKV_c05550	COG1404	Belongs to the peptidase S8 family
TKV_c05610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TKV_c05640	COG0517	IMP dehydrogenase activity
TKV_c05640	COG0516	GMP reductase activity
TKV_c05650	COG0519	Catalyzes the synthesis of GMP from XMP
TKV_c05650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TKV_c05660	COG2252	PERMEase
TKV_c05670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TKV_c05680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TKV_c05690	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TKV_c05700	COG0047	phosphoribosylformylglycinamidine synthase activity
TKV_c05710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TKV_c05720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TKV_c05730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TKV_c05740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TKV_c05760	COG0151	Belongs to the GarS family
TKV_c05770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TKV_c05780	COG1473	amidohydrolase
TKV_c05800	COG2244	polysaccharide biosynthetic process
TKV_c05820	COG3711	transcriptional antiterminator
TKV_c05840	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TKV_c05850	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TKV_c05860	COG1447	Phosphotransferase system cellobiose-specific component IIA
TKV_c05870	COG4496	protein, YerC YecD
TKV_c05880	COG0210	DNA helicase
TKV_c05900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TKV_c05920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TKV_c05930	COG4166	transmembrane transport
TKV_c05940	COG4166	transmembrane transport
TKV_c05950	COG0601	transmembrane transport
TKV_c05960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKV_c05970	COG0444	Belongs to the ABC transporter superfamily
TKV_c05980	COG4608	Belongs to the ABC transporter superfamily
TKV_c06040	COG0860	N-Acetylmuramoyl-L-alanine amidase
TKV_c06040	COG2247	cell wall binding repeat
TKV_c06050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TKV_c06170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_c06170	COG3711	transcriptional antiterminator
TKV_c06180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_c06180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_c06180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_c06190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_c06190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_c06190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_c06190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_c06190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_c06190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_c06200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_c06210	COG0622	Phosphoesterase
TKV_c06220	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TKV_c06220	COG0778	Nitroreductase
TKV_c06260	COG0559	Belongs to the binding-protein-dependent transport system permease family
TKV_c06280	COG0411	ABC transporter
TKV_c06290	COG0410	ABC transporter
TKV_c06300	COG0704	Plays a role in the regulation of phosphate uptake
TKV_c06310	COG3464	Transposase
TKV_c06320	COG3464	Transposase
TKV_c06330	COG3464	Transposase
TKV_c06350	COG0544	peptidyl-prolyl cis-trans isomerase activity
TKV_c06360	COG0740	serine-type endopeptidase activity
TKV_c06370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TKV_c06380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TKV_c06390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TKV_c06410	COG0356	it plays a direct role in the translocation of protons across the membrane
TKV_c06420	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TKV_c06430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TKV_c06440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TKV_c06450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TKV_c06460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TKV_c06470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TKV_c06480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TKV_c06500	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TKV_c06500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TKV_c06510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TKV_c06520	COG1116	anion transmembrane transporter activity
TKV_c06640	COG0673	inositol 2-dehydrogenase activity
TKV_c06650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TKV_c06680	COG1215	transferase activity, transferring glycosyl groups
TKV_c06710	COG0438	transferase activity, transferring glycosyl groups
TKV_c06720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TKV_c06740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TKV_c06760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TKV_c06790	COG1201	RNA secondary structure unwinding
TKV_c06870	COG1401	restriction endodeoxyribonuclease activity
TKV_c06890	COG2314	TM2 domain
TKV_c06900	COG1714	RDD family
TKV_c06940	COG1704	LemA family
TKV_c06950	COG0622	Phosphoesterase
TKV_c07120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TKV_c07130	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TKV_c07140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TKV_c07150	COG0531	amino acid
TKV_c07160	COG0250	Participates in transcription elongation, termination and antitermination
TKV_c07180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TKV_c07210	COG0489	protein tyrosine kinase activity
TKV_c07230	COG1316	TRANSCRIPTIONal
TKV_c07240	COG3949	Membrane
TKV_c07260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TKV_c07280	COG0105	UTP biosynthetic process
TKV_c07290	COG0477	Major facilitator Superfamily
TKV_c07320	COG0671	phosphoesterase, PA-phosphatase related
TKV_c07340	COG0156	8-amino-7-oxononanoate synthase activity
TKV_c07350	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
TKV_c07360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TKV_c07370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TKV_c07380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TKV_c07400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TKV_c07440	COG1606	tRNA processing
TKV_c07450	COG1691	(AIR) carboxylase
TKV_c07460	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TKV_c07470	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TKV_c07480	COG5002	protein histidine kinase activity
TKV_c07490	COG0745	RESPONSE REGULATOR receiver
TKV_c07530	COG1268	BioY protein
TKV_c07660	COG0493	'glutamate synthase
TKV_c07720	COG0616	signal peptide processing
TKV_c07730	COG0616	signal peptide processing
TKV_c07770	COG4555	ABC transporter
TKV_c07820	COG2986	histidine ammonia-lyase
TKV_c07910	COG1266	CAAX protease self-immunity
TKV_c08040	COG0525	valine-tRNA ligase activity
TKV_c08060	COG0285	dihydrofolate synthase activity
TKV_c08080	COG1151	hydroxylamine reductase activity
TKV_c08090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_c08240	COG1137	ATPase activity
TKV_c08280	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TKV_c08290	COG1609	Transcriptional regulator
TKV_c08320	COG1175	transmembrane transport
TKV_c08330	COG0395	ABC-type sugar transport system, permease component
TKV_c08340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TKV_c08360	COG2022	thiamine diphosphate biosynthetic process
TKV_c08380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TKV_c08390	COG0352	thiamine-phosphate diphosphorylase activity
TKV_c08460	COG1404	Belongs to the peptidase S8 family
TKV_c08470	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TKV_c08470	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TKV_c08510	COG3409	Peptidoglycan-binding domain 1 protein
TKV_c08510	COG3773	Cell wall hydrolase
TKV_c08560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TKV_c08570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TKV_c08580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TKV_c08640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TKV_c08650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TKV_c08670	COG0739	heme binding
TKV_c08730	COG1131	(ABC) transporter
TKV_c08750	COG0616	signal peptide processing
TKV_c08800	COG4475	Protein of unknown function (DUF436)
TKV_c08840	COG1983	PspC domain protein
TKV_c08860	COG1113	amino acid transport
TKV_c08890	COG1966	Carbon starvation protein
TKV_c08900	COG3279	Response regulator of the LytR AlgR family
TKV_c08910	COG3275	phosphorelay sensor kinase activity
TKV_c08920	COG1595	DNA-templated transcription, initiation
TKV_c08940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TKV_c08940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TKV_c08950	COG0237	dephospho-CoA kinase activity
TKV_c08960	COG0741	lytic transglycosylase activity
TKV_c08990	COG0352	thiamine-phosphate diphosphorylase activity
TKV_c09020	COG0791	NLP P60 protein
TKV_c09040	COG0741	lytic transglycosylase activity
TKV_c09070	COG0424	maF-like protein
TKV_c09080	COG2003	Belongs to the UPF0758 family
TKV_c09090	COG1077	Cell shape determining protein MreB Mrl
TKV_c09130	COG0850	regulation of cytokinetic process
TKV_c09140	COG2894	cell division
TKV_c09150	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TKV_c09160	COG0772	Belongs to the SEDS family
TKV_c09170	COG1803	Methylglyoxal synthase
TKV_c09180	COG0739	heme binding
TKV_c09190	COG1994	Peptidase M50
TKV_c09190	COG0517	IMP dehydrogenase activity
TKV_c09220	COG1530	ribonuclease E activity
TKV_c09230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TKV_c09240	COG4708	membrane
TKV_c09250	COG5416	Lipopolysaccharide assembly protein A domain
TKV_c09260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TKV_c09280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TKV_c09300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TKV_c09310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TKV_c09320	COG1713	HD superfamily hydrolase involved in NAD metabolism
TKV_c09330	COG1316	TRANSCRIPTIONal
TKV_c09340	COG0799	negative regulation of ribosome biogenesis
TKV_c09380	COG0367	asparagine synthase
TKV_c09390	COG1686	Belongs to the peptidase S11 family
TKV_c09400	COG1596	polysaccharide export
TKV_c09400	COG1555	photosystem II stabilization
TKV_c09420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TKV_c09480	COG0318	PFAM AMP-dependent synthetase and ligase
TKV_c09560	COG0084	hydrolase, TatD family'
TKV_c09630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TKV_c09690	COG1429	ligase activity, forming nitrogen-metal bonds
TKV_c09700	COG0310	cobalt ion transport
TKV_c09720	COG3437	response regulator, receiver
TKV_c09720	COG2770	Histidine kinase
TKV_c09730	COG3706	GGDEF domain
TKV_c09750	COG4720	Psort location CytoplasmicMembrane, score
TKV_c09780	COG0658	competence protein
TKV_c09780	COG2333	competence protein COMEC
TKV_c09800	COG0268	Binds directly to 16S ribosomal RNA
TKV_c09820	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TKV_c09870	COG0481	GTPase activity
TKV_c09880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TKV_c09890	COG1420	regulation of RNA biosynthetic process
TKV_c09900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TKV_c09910	COG0443	Heat shock 70 kDa protein
TKV_c09920	COG0484	heat shock protein binding
TKV_c09930	COG2264	protein methyltransferase activity
TKV_c09940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TKV_c09950	COG3830	Belongs to the UPF0237 family
TKV_c09970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TKV_c09980	COG0537	adenosine 5'-monophosphoramidase activity
TKV_c09990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TKV_c10030	COG1702	phosphate starvation-inducible protein PhoH
TKV_c10040	COG1480	7TM receptor with intracellular HD hydrolase
TKV_c10050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TKV_c10060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TKV_c10070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TKV_c10100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TKV_c10130	COG0423	glycine-tRNA ligase activity
TKV_c10140	COG0517	IMP dehydrogenase activity
TKV_c10150	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TKV_c10160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TKV_c10160	COG0574	Belongs to the PEP-utilizing enzyme family
TKV_c10180	COG0557	exoribonuclease II activity
TKV_c10210	COG0601	transmembrane transport
TKV_c10230	COG0444	Belongs to the ABC transporter superfamily
TKV_c10240	COG4608	Belongs to the ABC transporter superfamily
TKV_c10260	COG2345	Transcriptional regulator
TKV_c10290	COG0747	negative chemotaxis
TKV_c10300	COG1429	ligase activity, forming nitrogen-metal bonds
TKV_c10380	COG0583	DNA-binding transcription factor activity
TKV_c10400	COG0446	pyridine nucleotide-disulphide oxidoreductase
TKV_c10400	COG1902	pentaerythritol trinitrate reductase activity
TKV_c10410	COG2267	carboxylic ester hydrolase activity
TKV_c10450	COG0584	glycerophosphoryl diester phosphodiesterase
TKV_c10480	COG1968	undecaprenyl-diphosphatase activity
TKV_c10510	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TKV_c10520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TKV_c10530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TKV_c10530	COG0574	Belongs to the PEP-utilizing enzyme family
TKV_c10550	COG1131	(ABC) transporter
TKV_c10640	COG1923	regulation of RNA biosynthetic process
TKV_c10690	COG1215	transferase activity, transferring glycosyl groups
TKV_c10710	COG3069	C4-dicarboxylate transmembrane transporter activity
TKV_c10740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TKV_c10760	COG4632	Exopolysaccharide biosynthesis protein
TKV_c10760	COG5434	Belongs to the glycosyl hydrolase 28 family
TKV_c10780	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TKV_c10790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TKV_c10820	COG1760	l-serine dehydratase
TKV_c10830	COG1164	Oligoendopeptidase f
TKV_c10840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TKV_c10850	COG0077	Prephenate dehydratase
TKV_c10850	COG1605	Chorismate mutase
TKV_c10860	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TKV_c10870	COG0287	Prephenate dehydrogenase
TKV_c10880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TKV_c10890	COG0745	RESPONSE REGULATOR receiver
TKV_c10900	COG5002	protein histidine kinase activity
TKV_c10910	COG3773	Cell wall hydrolase
TKV_c10910	COG3409	Peptidoglycan-binding domain 1 protein
TKV_c10920	COG2119	membrane
TKV_c10940	COG1940	carbohydrate kinase activity
TKV_c10960	COG3118	belongs to the thioredoxin family
TKV_c10970	COG1982	Orn Lys Arg decarboxylase major
TKV_c11020	COG1523	belongs to the glycosyl hydrolase 13 family
TKV_c11040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TKV_c11050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TKV_c11060	COG0297	glycogen (starch) synthase activity
TKV_c11160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TKV_c11190	COG1739	Uncharacterized protein family UPF0029
TKV_c11240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TKV_c11250	COG0217	transcriptional regulatory protein
TKV_c11260	COG0835	chemotaxis
TKV_c11280	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TKV_c11290	COG0632	four-way junction helicase activity
TKV_c11300	COG2255	four-way junction helicase activity
TKV_c11320	COG2385	sporulation resulting in formation of a cellular spore
TKV_c11320	COG2247	cell wall binding repeat
TKV_c11350	COG3706	GGDEF domain
TKV_c11400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TKV_c11410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TKV_c11420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TKV_c11440	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TKV_c11440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TKV_c11450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TKV_c11460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TKV_c11480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TKV_c11510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TKV_c11520	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TKV_c11530	COG1937	Protein conserved in bacteria
TKV_c11540	COG3118	belongs to the thioredoxin family
TKV_c11570	COG1959	2 iron, 2 sulfur cluster binding
TKV_c11580	COG0482	sulfurtransferase activity
TKV_c11600	COG0628	permease
TKV_c11610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TKV_c11620	COG4472	Bacterial protein of unknown function (DUF965)
TKV_c11630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TKV_c11650	COG0735	belongs to the Fur family
TKV_c11660	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TKV_c11670	COG3679	Belongs to the UPF0342 family
TKV_c11680	COG4708	membrane
TKV_c11690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TKV_c11720	COG0768	penicillin binding
TKV_c11730	COG1191	sigma factor activity
TKV_c11750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TKV_c11790	COG2165	general secretion pathway protein
TKV_c11800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TKV_c11910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TKV_c11920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TKV_c11930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TKV_c11940	COG0006	proline dipeptidase activity
TKV_c11950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TKV_c11970	COG3854	ATPases associated with a variety of cellular activities
TKV_c12050	COG1302	Protein conserved in bacteria
TKV_c12080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TKV_c12090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TKV_c12100	COG1570	exodeoxyribonuclease VII activity
TKV_c12140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TKV_c12150	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TKV_c12160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TKV_c12170	COG1438	arginine binding
TKV_c12180	COG0497	DNA recombination
TKV_c12190	COG0750	zinc metalloprotease
TKV_c12200	COG0745	RESPONSE REGULATOR receiver
TKV_c12210	COG3464	Transposase
TKV_c12320	COG1379	DNA repair
TKV_c12330	COG1300	Membrane
TKV_c12340	COG4974	Belongs to the 'phage' integrase family
TKV_c12350	COG1686	Belongs to the peptidase S11 family
TKV_c12360	COG1366	Belongs to the anti-sigma-factor antagonist family
TKV_c12370	COG2172	sigma factor antagonist activity
TKV_c12390	COG3360	Dodecin
TKV_c12440	COG1994	Peptidase M50
TKV_c12450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TKV_c12460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TKV_c12470	COG4086	secreted protein
TKV_c12490	COG3874	Sporulation protein YtfJ
TKV_c12510	COG1686	Belongs to the peptidase S11 family
TKV_c12530	COG0445	tRNA wobble uridine modification
TKV_c12540	COG1187	pseudouridine synthase activity
TKV_c12550	COG0456	acetyltransferase
TKV_c12560	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TKV_c12590	COG1388	LysM domain
TKV_c12590	COG1705	Flagellar rod assembly protein muramidase FlgJ
TKV_c12610	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TKV_c12650	COG2081	HI0933 family
TKV_c12670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TKV_c12690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TKV_c12700	COG0539	negative regulation of cytoplasmic translation
TKV_c12700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TKV_c12710	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TKV_c12720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TKV_c12740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TKV_c12750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TKV_c12760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TKV_c12770	COG1923	regulation of RNA biosynthetic process
TKV_c12780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TKV_c12790	COG0328	RNA-DNA hybrid ribonuclease activity
TKV_c12800	COG4974	Belongs to the 'phage' integrase family
TKV_c12810	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TKV_c12820	COG0464	growth
TKV_c12830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TKV_c12860	COG2359	stage V sporulation protein S
TKV_c12870	COG1692	metallophosphoesterase
TKV_c12900	COG1418	mRNA catabolic process
TKV_c12910	COG2137	regulation of response to DNA damage stimulus
TKV_c12920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TKV_c12930	COG1058	Belongs to the CinA family
TKV_c12930	COG1546	Belongs to the CinA family
TKV_c12950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TKV_c12960	COG1674	ftsk spoiiie
TKV_c12980	COG0740	serine-type endopeptidase activity
TKV_c12990	COG0527	aspartate kinase activity
TKV_c13010	COG0756	dUTP diphosphatase activity
TKV_c13020	COG0612	Peptidase, M16
TKV_c13030	COG0726	polysaccharide deacetylase
TKV_c13040	COG1185	polyribonucleotide nucleotidyltransferase activity
TKV_c13050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TKV_c13060	COG0196	riboflavin kinase activity
TKV_c13070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TKV_c13080	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TKV_c13090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TKV_c13120	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TKV_c13130	COG0195	Participates in both transcription termination and antitermination
TKV_c13140	COG0779	Required for maturation of 30S ribosomal subunits
TKV_c13150	COG2176	DNA-directed DNA polymerase activity
TKV_c13170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TKV_c13180	COG0750	zinc metalloprotease
TKV_c13210	COG0750	zinc metalloprotease
TKV_c13220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TKV_c13230	COG4589	Belongs to the CDS family
TKV_c13240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TKV_c13260	COG0233	cytoplasmic translational termination
TKV_c13270	COG0528	UMP kinase activity
TKV_c13280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TKV_c13290	COG0052	Belongs to the universal ribosomal protein uS2 family
TKV_c13320	COG1191	sigma factor activity
TKV_c13330	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TKV_c13340	COG1776	CheC inhibitor of MCP methylation
TKV_c13350	COG0835	chemotaxis
TKV_c13360	COG2198	Histidine kinase
TKV_c13360	COG0643	Histidine kinase
TKV_c13370	COG2201	protein-glutamate methylesterase activity
TKV_c13390	COG0455	bacterial-type flagellum organization
TKV_c13400	COG1419	protein localization to endoplasmic reticulum
TKV_c13410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TKV_c13420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TKV_c13430	COG1684	flagellar biosynthetic protein fliR
TKV_c13440	COG1987	bacterial-type flagellum assembly
TKV_c13450	COG1338	Plays a role in the flagellum-specific transport system
TKV_c13460	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TKV_c13480	COG1582	Flagellar protein (FlbD)
TKV_c13510	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TKV_c13550	COG1157	protein secretion by the type III secretion system
TKV_c13570	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TKV_c13580	COG1766	The M ring may be actively involved in energy transduction
TKV_c13590	COG1677	Flagellar hook-basal body complex protein FliE
TKV_c13610	COG1815	bacterial-type flagellum-dependent cell motility
TKV_c13620	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TKV_c13630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TKV_c13640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TKV_c13650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TKV_c13660	COG0758	DNA mediated transformation
TKV_c13670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TKV_c13680	COG0792	nuclease activity
TKV_c13690	COG0180	Tryptophanyl-tRNA synthetase
TKV_c13700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TKV_c13730	COG0335	large ribosomal subunit rRNA binding
TKV_c13740	COG0336	Belongs to the RNA methyltransferase TrmD family
TKV_c13750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TKV_c13760	COG1837	Belongs to the UPF0109 family
TKV_c13770	COG0228	four-way junction DNA binding
TKV_c13780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TKV_c13800	COG0552	protein localization to endoplasmic reticulum
TKV_c13810	COG1196	nuclear chromosome segregation
TKV_c13830	COG2359	stage V sporulation protein S
TKV_c13850	COG0571	ribonuclease III activity
TKV_c13860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TKV_c13870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TKV_c13880	COG1028	Short-chain dehydrogenase reductase Sdr
TKV_c13890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TKV_c13900	COG2070	2-Nitropropane dioxygenase
TKV_c13910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TKV_c13930	COG2030	dehydratase
TKV_c13940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TKV_c13960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TKV_c13970	COG0280	phosphate acetyltransferase
TKV_c13990	COG3314	Sporulation integral membrane protein YlbJ
TKV_c14010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TKV_c14020	COG0742	ribosomal rna small subunit methyltransferase
TKV_c14050	COG1307	EDD domain protein, DegV family
TKV_c14060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TKV_c14070	COG1461	Dihydroxyacetone kinase
TKV_c14080	COG1302	Protein conserved in bacteria
TKV_c14120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TKV_c14130	COG1162	GTPase activity
TKV_c14140	COG0515	serine threonine protein kinase
TKV_c14140	COG2815	serine threonine protein kinase
TKV_c14150	COG0631	protein serine/threonine phosphatase activity
TKV_c14160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TKV_c14170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TKV_c14170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TKV_c14180	COG2738	Putative neutral zinc metallopeptidase
TKV_c14200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TKV_c14210	COG0242	peptide deformylase activity
TKV_c14220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TKV_c14230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TKV_c14240	COG0194	GDP metabolic process
TKV_c14260	COG1561	YicC-like family, N-terminal region
TKV_c14270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TKV_c14280	COG2814	Major facilitator Superfamily
TKV_c14350	COG0037	tRNA processing
TKV_c14380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TKV_c14400	COG0543	2 iron, 2 sulfur cluster binding
TKV_c14420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TKV_c14430	COG0540	Belongs to the ATCase OTCase family
TKV_c14440	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TKV_c14450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TKV_c14460	COG0564	pseudouridine synthase activity
TKV_c14470	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TKV_c14550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TKV_c14620	COG1337	RAMP superfamily
TKV_c14720	COG1970	mechanosensitive ion channel activity
TKV_c14780	COG1983	PspC domain protein
TKV_c14820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TKV_c14830	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TKV_c14870	COG0134	indole-3-glycerol-phosphate synthase activity
TKV_c14880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TKV_c14890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TKV_c14890	COG0512	Glutamine amidotransferase of anthranilate synthase
TKV_c14920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TKV_c14930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TKV_c14950	COG3599	regulation of cell shape
TKV_c14960	COG2302	S4 RNA-binding domain
TKV_c14980	COG1799	cell septum assembly
TKV_c14990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TKV_c15010	COG3033	Beta-eliminating lyase
TKV_c15060	COG0157	Belongs to the NadC ModD family
TKV_c15070	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TKV_c15080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TKV_c15120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TKV_c15150	COG1160	GTP binding
TKV_c15230	COG0704	Plays a role in the regulation of phosphate uptake
TKV_c15240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TKV_c15250	COG0581	inorganic phosphate transmembrane transporter activity
TKV_c15260	COG0573	inorganic phosphate transmembrane transporter activity
TKV_c15280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TKV_c15290	COG5002	protein histidine kinase activity
TKV_c15300	COG0745	RESPONSE REGULATOR receiver
TKV_c15310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TKV_c15320	COG1873	PFAM PRC-barrel domain
TKV_c15330	COG1191	sigma factor activity
TKV_c15340	COG1191	sigma factor activity
TKV_c15360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TKV_c15370	COG0849	cell division
TKV_c15380	COG3856	small basic protein
TKV_c15400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TKV_c15410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TKV_c15420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TKV_c15430	COG0772	Belongs to the SEDS family
TKV_c15450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TKV_c15460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TKV_c15470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TKV_c15480	COG0768	penicillin binding
TKV_c15520	COG0612	Peptidase, M16
TKV_c15530	COG0612	Peptidase, M16
TKV_c15550	COG0012	GTP binding
TKV_c15620	COG2033	superoxide reductase activity
TKV_c15640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TKV_c15660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TKV_c15670	COG0321	lipoyl(octanoyl) transferase activity
TKV_c15680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TKV_c15710	COG2340	Cysteine-rich secretory protein family
TKV_c15720	COG1362	aminopeptidase activity
TKV_c15730	COG2197	response regulator
TKV_c15770	COG1683	Conserved Protein
TKV_c15780	COG1193	negative regulation of DNA recombination
TKV_c15790	COG0826	peptidase U32
TKV_c15840	COG0072	phenylalanine-tRNA ligase activity
TKV_c15840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TKV_c15850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TKV_c15860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TKV_c15870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TKV_c15880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TKV_c15890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TKV_c15900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TKV_c15920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TKV_c15930	COG4399	Belongs to the UPF0754 family
TKV_c15960	COG0745	RESPONSE REGULATOR receiver
TKV_c15970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TKV_c16050	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TKV_c16060	COG1278	Cold shock
TKV_c16070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TKV_c16100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TKV_c16120	COG1956	GAF domain-containing protein
TKV_c16140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TKV_c16160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TKV_c16180	COG1482	cell wall glycoprotein biosynthetic process
TKV_c16190	COG0813	purine-nucleoside phosphorylase activity
TKV_c16220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TKV_c16230	COG2384	SAM-dependent methyltransferase
TKV_c16260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TKV_c16270	COG0358	DNA primase activity
TKV_c16280	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TKV_c16290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TKV_c16330	COG0126	phosphoglycerate kinase activity
TKV_c16350	COG2390	Transcriptional regulator
TKV_c16360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TKV_c16370	COG1254	Belongs to the acylphosphatase family
TKV_c16380	COG0561	phosphatase activity
TKV_c16400	COG2720	vancomycin resistance protein
TKV_c16410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TKV_c16420	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TKV_c16430	COG1067	ATP-dependent peptidase activity
TKV_c16480	COG1120	ATPase activity
TKV_c16490	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TKV_c16530	COG4607	ABC-type enterochelin transport system periplasmic component
TKV_c16550	COG0842	Transport permease protein
TKV_c16560	COG1131	(ABC) transporter
TKV_c16580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TKV_c16590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TKV_c16610	COG0564	pseudouridine synthase activity
TKV_c16640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TKV_c16700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TKV_c16730	COG3546	catalase activity
TKV_c16740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TKV_c16750	COG0646	methionine synthase
TKV_c16750	COG1410	methionine synthase
TKV_c16770	COG0058	SHG alpha-glucan phosphorylase activity
TKV_c16780	COG0166	Belongs to the GPI family
TKV_c16790	COG0778	Nitroreductase
TKV_c16800	COG2195	Cleaves the N-terminal amino acid of tripeptides
TKV_c16820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TKV_c16830	COG0534	Mate efflux family protein
TKV_c16870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TKV_c16900	COG0205	6-phosphofructokinase activity
TKV_c16930	COG4109	DRTGG domain
TKV_c16940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_c16950	COG1481	regulation of sporulation
TKV_c16970	COG0366	Alpha amylase catalytic
TKV_c16980	COG1426	Protein conserved in bacteria
TKV_c17010	COG3833	ABC-type maltose transport systems, permease component
TKV_c17020	COG3464	Transposase
TKV_c17040	COG1175	transmembrane transport
TKV_c17050	COG2182	Extracellular solute-binding protein
TKV_c17100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TKV_c17130	COG1752	Esterase of the alpha-beta hydrolase superfamily
TKV_c17140	COG1309	transcriptional regulator
TKV_c17150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TKV_c17190	COG0671	phosphoesterase, PA-phosphatase related
TKV_c17200	COG0745	RESPONSE REGULATOR receiver
TKV_c17220	COG2217	Heavy metal translocating P-type atpase
TKV_c17240	COG2608	mercury ion transmembrane transporter activity
TKV_c17250	COG0586	Pfam SNARE associated Golgi protein
TKV_c17280	COG5002	protein histidine kinase activity
TKV_c17280	COG5001	Diguanylate cyclase
TKV_c17350	COG1337	RAMP superfamily
TKV_c17430	COG1120	ATPase activity
TKV_c17440	COG4139	cobalamin transport
TKV_c17490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TKV_c17570	COG0589	response to stress
TKV_c17710	COG0768	penicillin binding
TKV_c17770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TKV_c17780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TKV_c17820	COG0673	inositol 2-dehydrogenase activity
TKV_c17830	COG0673	inositol 2-dehydrogenase activity
TKV_c17880	COG3885	ferrous iron binding
TKV_c17880	COG2078	PFAM AMMECR1 domain protein
TKV_c17900	COG0318	PFAM AMP-dependent synthetase and ligase
TKV_c17910	COG1940	carbohydrate kinase activity
TKV_c17930	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TKV_c17960	COG0768	penicillin binding
TKV_c18000	COG0556	nucleotide-excision repair
TKV_c18010	COG2045	Belongs to the ComB family
TKV_c18020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TKV_c18030	COG3409	Peptidoglycan-binding domain 1 protein
TKV_c18030	COG0793	Belongs to the peptidase S41A family
TKV_c18040	COG0739	heme binding
TKV_c18050	COG2177	Part of the ABC transporter FtsEX involved in
TKV_c18060	COG2884	Cell division ATP-binding protein ftsE
TKV_c18070	COG3835	regulator
TKV_c18080	COG3842	ATPase activity
TKV_c18100	COG0019	diaminopimelate decarboxylase activity
TKV_c18110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TKV_c18130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TKV_c18150	COG4166	transmembrane transport
TKV_c18160	COG0849	cell division
TKV_c18240	COG0443	Heat shock 70 kDa protein
TKV_c18310	COG2205	protein histidine kinase activity
TKV_c18320	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TKV_c18330	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TKV_c18340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TKV_c18360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TKV_c18370	COG1283	sodium-dependent phosphate transmembrane transporter activity
TKV_c18380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TKV_c18400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TKV_c18410	COG0140	phosphoribosyl-ATP diphosphatase activity
TKV_c18410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TKV_c18440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TKV_c18450	COG0131	Imidazoleglycerol-phosphate dehydratase
TKV_c18470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TKV_c18480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TKV_c18570	COG1131	(ABC) transporter
TKV_c18580	COG3459	Glycosyltransferase 36 associated
TKV_c18590	COG0598	Magnesium transport protein CorA
TKV_c18600	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TKV_c18600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TKV_c18620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TKV_c18640	COG0460	homoserine dehydrogenase
TKV_c18670	COG0315	cyclic pyranopterin monophosphate synthase activity
TKV_c18690	COG1910	domain protein
TKV_c18700	COG0303	'Molybdopterin
TKV_c18710	COG0521	Mo-molybdopterin cofactor biosynthetic process
TKV_c18770	COG2226	methyltransferase
TKV_c18790	COG5001	Diguanylate cyclase
TKV_c18790	COG4251	negative regulation of phosphorylation
TKV_c18790	COG3706	GGDEF domain
TKV_c18790	COG2203	Gaf domain
TKV_c18810	COG0205	6-phosphofructokinase activity
TKV_c18830	COG3958	Transketolase
TKV_c18840	COG3959	Transketolase, thiamine diphosphate binding domain
TKV_c18850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TKV_c18900	COG2337	Toxic component of a toxin-antitoxin (TA) module
TKV_c18920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TKV_c18940	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TKV_c18940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TKV_c18950	COG0736	holo-[acyl-carrier-protein] synthase activity
TKV_c19010	COG1971	Probably functions as a manganese efflux pump
TKV_c19030	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TKV_c19040	COG1793	dna ligase
TKV_c19050	COG0432	Pfam Uncharacterised protein family UPF0047
TKV_c19100	COG0509	glycine decarboxylation via glycine cleavage system
TKV_c19200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TKV_c19220	COG0204	Acyl-transferase
TKV_c19220	COG0318	PFAM AMP-dependent synthetase and ligase
TKV_c19250	COG0280	phosphate acetyltransferase
TKV_c19310	COG3426	butyrate kinase activity
TKV_c19320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TKV_c19330	COG0280	phosphate acetyltransferase
TKV_c19340	COG3426	butyrate kinase activity
TKV_c19360	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TKV_c19430	COG1705	Flagellar rod assembly protein muramidase FlgJ
TKV_c19430	COG1388	LysM domain
TKV_c19480	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TKV_c19510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TKV_c19570	COG0583	DNA-binding transcription factor activity
TKV_c19610	COG0864	Transcriptional regulator
TKV_c19620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TKV_c19630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TKV_c19680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TKV_c19690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TKV_c19700	COG3260	NADH ubiquinone oxidoreductase 20
TKV_c19720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TKV_c19720	COG2111	Na H antiporter
TKV_c19750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TKV_c19810	COG0509	glycine decarboxylation via glycine cleavage system
TKV_c19870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TKV_c19880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TKV_c19900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TKV_c19910	COG3404	Formiminotransferase-cyclodeaminase
TKV_c19940	COG2116	formate transmembrane transporter activity
TKV_c19950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TKV_c19970	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_c19980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_c19990	COG3383	formate dehydrogenase (NAD+) activity
TKV_c20000	COG0746	molybdenum cofactor guanylyltransferase activity
TKV_c20020	COG3842	ATPase activity
TKV_c20060	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TKV_c20070	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TKV_c20080	COG0321	lipoyl(octanoyl) transferase activity
TKV_c20100	COG1151	hydroxylamine reductase activity
TKV_c20110	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_c20220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TKV_c20230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TKV_c20240	COG0101	tRNA pseudouridine synthase activity
TKV_c20250	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TKV_c20260	COG1122	ATPase activity
TKV_c20270	COG1122	ATPase activity
TKV_c20280	COG0203	ribosomal protein L17
TKV_c20290	COG0202	RNA polymerase activity
TKV_c20300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TKV_c20310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TKV_c20320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TKV_c20340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TKV_c20370	COG0563	adenylate kinase activity
TKV_c20380	COG0201	protein transport
TKV_c20390	COG0200	Binds to the 23S rRNA
TKV_c20400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TKV_c20410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TKV_c20430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TKV_c20440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TKV_c20450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TKV_c20460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TKV_c20470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TKV_c20480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TKV_c20490	COG0255	Belongs to the universal ribosomal protein uL29 family
TKV_c20510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TKV_c20520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TKV_c20530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TKV_c20540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TKV_c20550	COG0089	rRNA binding
TKV_c20560	COG0088	Forms part of the polypeptide exit tunnel
TKV_c20570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TKV_c20580	COG0051	transcription antitermination factor activity, RNA binding
TKV_c20590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TKV_c20600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TKV_c20610	COG0049	tRNA binding
TKV_c20620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TKV_c20630	COG1358	cellular component organization or biogenesis
TKV_c20640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TKV_c20650	COG0085	RNA polymerase activity
TKV_c20660	COG0222	ribosome binding
TKV_c20680	COG0081	regulation of translation
TKV_c20690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TKV_c20700	COG0250	Participates in transcription elongation, termination and antitermination
TKV_c20710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TKV_c20720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TKV_c20740	COG1595	DNA-templated transcription, initiation
TKV_c20750	COG3688	RNA-binding protein containing a PIN domain
TKV_c20760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TKV_c20780	COG0215	cysteine-tRNA ligase activity
TKV_c20790	COG1045	serine acetyltransferase
TKV_c20830	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TKV_c20850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TKV_c20860	COG4956	integral membrane protein (PIN domain superfamily)
TKV_c20880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TKV_c20890	COG1914	H( )-stimulated, divalent metal cation uptake system
TKV_c20910	COG0542	response to heat
TKV_c20920	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TKV_c20930	COG3880	PFAM UvrB UvrC protein
TKV_c20960	COG0281	malic enzyme
TKV_c20970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TKV_c20980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TKV_c20990	COG3706	GGDEF domain
TKV_c20990	COG0745	RESPONSE REGULATOR receiver
TKV_c21030	COG4224	UPF0291 protein
TKV_c21080	COG1489	DNA binding
TKV_c21090	COG0720	synthase
TKV_c21100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TKV_c21110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TKV_c21120	COG0302	gtp cyclohydrolase
TKV_c21130	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TKV_c21140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TKV_c21150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TKV_c21150	COG5322	oxidoreductase activity
TKV_c21210	COG0697	spore germination
TKV_c21220	COG0531	amino acid
TKV_c21230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TKV_c21240	COG4684	Psort location CytoplasmicMembrane, score
TKV_c21250	COG4770	biotin carboxylase activity
TKV_c21270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TKV_c21280	COG1703	isobutyryl-CoA mutase activity
TKV_c21280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TKV_c21280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TKV_c21300	COG3852	Histidine kinase
TKV_c21330	COG0037	tRNA processing
TKV_c21350	COG2208	phosphoserine phosphatase activity
TKV_c21370	COG2226	methyltransferase
TKV_c21380	COG0697	spore germination
TKV_c21390	COG1595	DNA-templated transcription, initiation
TKV_c21410	COG1131	(ABC) transporter
TKV_c21460	COG1063	alcohol dehydrogenase
TKV_c21500	COG2247	cell wall binding repeat
TKV_c21500	COG0860	N-Acetylmuramoyl-L-alanine amidase
TKV_c21510	COG3842	ATPase activity
TKV_c21600	COG1131	(ABC) transporter
TKV_c21610	COG0640	Transcriptional regulator
TKV_c21620	COG0556	nucleotide-excision repair
TKV_c21700	COG1337	RAMP superfamily
TKV_c21810	COG1396	sequence-specific DNA binding
TKV_c21850	COG0248	Ppx GppA phosphatase
TKV_c21850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TKV_c21860	COG1098	S1 RNA binding domain
TKV_c21920	COG2385	sporulation resulting in formation of a cellular spore
TKV_c21930	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TKV_c21940	COG0776	regulation of translation
TKV_c21950	COG3956	TIGRFAM MazG family protein
TKV_c21970	COG2814	Major facilitator Superfamily
TKV_c21980	COG1160	GTP binding
TKV_c21990	COG1027	Aspartate ammonia-lyase
TKV_c22000	COG3850	Histidine kinase
TKV_c22000	COG5002	protein histidine kinase activity
TKV_c22010	COG0745	RESPONSE REGULATOR receiver
TKV_c22020	COG2033	superoxide reductase activity
TKV_c22080	COG3464	Transposase
TKV_c22170	COG0165	Argininosuccinate lyase
TKV_c22200	COG0505	Belongs to the CarA family
TKV_c22210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TKV_c22220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TKV_c22230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TKV_c22240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TKV_c22280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_c22280	COG0493	'glutamate synthase
TKV_c22290	COG1796	DNA polymerase
TKV_c22290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TKV_c22310	COG1131	(ABC) transporter
TKV_c22350	COG1595	DNA-templated transcription, initiation
TKV_c22600	COG0671	phosphoesterase, PA-phosphatase related
TKV_c22610	COG3859	Proton-coupled thiamine transporter YuaJ
TKV_c22620	COG1132	(ABC) transporter
TKV_c22640	COG1846	Transcriptional regulator
TKV_c22690	COG0667	Aldo Keto reductase
TKV_c22750	COG1131	(ABC) transporter
TKV_c22770	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TKV_c22780	COG0018	arginyl-trna synthetase
TKV_c22800	COG1181	Belongs to the D-alanine--D-alanine ligase family
TKV_c22820	COG2959	enzyme of heme biosynthesis
TKV_c22830	COG3773	Cell wall hydrolase
TKV_c22830	COG3409	Peptidoglycan-binding domain 1 protein
TKV_c22860	COG0531	amino acid
TKV_c22870	COG0697	spore germination
TKV_c22910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TKV_c22930	COG4466	Protein conserved in bacteria
TKV_c22940	COG3464	Transposase
TKV_c22960	COG2002	toxin-antitoxin pair type II binding
TKV_c22970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TKV_c22980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TKV_c23010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TKV_c23020	COG5002	protein histidine kinase activity
TKV_c23020	COG3850	Histidine kinase
TKV_c23030	COG0745	RESPONSE REGULATOR receiver
TKV_c23040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TKV_c23050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TKV_c23070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TKV_c23080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TKV_c23110	COG0071	Belongs to the small heat shock protein (HSP20) family
TKV_c23140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_c23140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_c23140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_c23160	COG1349	DNA-binding transcription factor activity
TKV_c23170	COG2373	Large extracellular alpha-helical protein
TKV_c23210	COG0515	serine threonine protein kinase
TKV_c23210	COG4991	sh3 domain protein
TKV_c23210	COG3064	Membrane
TKV_c23240	COG0504	CTP synthase activity
TKV_c23310	COG0561	phosphatase activity
TKV_c23340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKV_c23350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TKV_c23390	COG0083	homoserine kinase activity
TKV_c23400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TKV_c23410	COG0460	homoserine dehydrogenase
TKV_c23420	COG4492	Belongs to the UPF0735 family
TKV_c23430	COG0531	amino acid
TKV_c23440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TKV_c23460	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TKV_c23490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TKV_c23590	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TKV_c23600	COG1518	maintenance of DNA repeat elements
TKV_c23780	COG0822	iron-sulfur transferase activity
TKV_c23790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TKV_c23810	COG0719	Fe-S assembly protein
TKV_c23820	COG0396	ATPase activity
TKV_c23830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TKV_c23870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TKV_c23910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TKV_c23920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TKV_c23960	COG5002	protein histidine kinase activity
TKV_c23990	COG0739	heme binding
TKV_c24050	COG0658	competence protein
TKV_c24050	COG2333	competence protein COMEC
TKV_c24090	COG0482	sulfurtransferase activity
TKV_c24110	COG0069	glutamate synthase activity
TKV_c24110	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TKV_c24120	COG0067	glutamate synthase
TKV_c24130	COG0505	Belongs to the CarA family
TKV_c24140	COG0347	Belongs to the P(II) protein family
TKV_c24150	COG0004	ammonium transporteR
TKV_c24210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TKV_c24220	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TKV_c24230	COG0840	transmembrane signaling receptor activity
TKV_c24250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TKV_c24280	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TKV_c24290	COG1518	maintenance of DNA repeat elements
TKV_c24450	COG0284	orotidine-5'-phosphate decarboxylase activity
TKV_c24520	COG1151	hydroxylamine reductase activity
TKV_c24530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TKV_c24540	COG0305	Participates in initiation and elongation during chromosome replication
TKV_c24550	COG0359	binds to the 23S rRNA
TKV_c24560	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TKV_c24590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TKV_c24600	COG0629	single-stranded DNA binding
TKV_c24610	COG0360	Binds together with S18 to 16S ribosomal RNA
TKV_c24620	COG4481	Protein conserved in bacteria
TKV_c24630	COG0668	transmembrane transport
TKV_c24660	COG4242	Belongs to the peptidase S51 family
TKV_c24690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TKV_c24700	COG1475	DNA binding
TKV_c24710	COG1192	Involved in chromosome partitioning
TKV_c24760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TKV_c24770	COG1847	R3H domain protein
TKV_c24780	COG0706	membrane insertase activity
TKV_c24790	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TKV_c24800	COG0594	ribonuclease P activity
TKV_c24810	COG0230	Belongs to the bacterial ribosomal protein bL34 family