locus-tag class description Tmath_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Tmath_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Tmath_0003 ENOG410848D S4 domain protein YaaA Tmath_0007 ENOG4105F1K Glutamine amidotransferase Tmath_0009 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tmath_0010 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tmath_0014 ENOG4108K9K Uncharacterised protein family (UPF0236) Tmath_0021 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) Tmath_0022 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Tmath_0024 ENOG4105DTT CRISPR-associated helicase, cas3 Tmath_0027 ENOG4108QCZ crispr-associated cxxc_cxxc protein cst1 Tmath_0029 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Tmath_0030 ENOG4108ZP8 Acetolactate synthase small subunit Tmath_0032 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Tmath_0034 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tmath_0035 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Tmath_0036 ENOG4105C01 Dihydroxy-acid dehydratase Tmath_0037 ENOG4105C7K acetolactate synthase Tmath_0038 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Tmath_0039 ENOG4108R6K riboflavin synthase, subunit alpha Tmath_0042 ENOG4108REF Sporulation integral membrane protein ytvi Tmath_0045 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Tmath_0046 ENOG4108KGH TRANSCRIPTIONal Tmath_0047 ENOG4105DJZ UPF0182 protein Tmath_0048 ENOG4105VTR Integrase Tmath_0052 ENOG41067QW Transcriptional regulator Tmath_0061 ENOG4107QMS site-determining protein Tmath_0062 ENOG4108EHY type IV secretion system Tmath_0070 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tmath_0084 ENOG4105DR5 peptidase Tmath_0096 ENOG41071TK Uncharacterised protein family (UPF0150) Tmath_0098 ENOG4108Z6B deaminase Tmath_0099 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tmath_0100 ENOG4105C6E dna polymerase iii Tmath_0101 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Tmath_0102 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Tmath_0103 ENOG4105WMR Protein CrcB homolog Tmath_0104 ENOG4105WMR Protein CrcB homolog Tmath_0105 ENOG4105DHT Metal Dependent Phosphohydrolase Tmath_0109 ENOG4105CHR reductase Tmath_0112 ENOG4105CKB glycosidase Tmath_0113 ENOG4105CKB glycosidase Tmath_0117 ENOG4105CPF Cell wall formation (By similarity) Tmath_0118 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Tmath_0119 ENOG4108IG5 Transcriptional regulator Tmath_0120 ENOG4105ECB domain protein Tmath_0123 ENOG4106DSS Tartrate dehydratase subunit alpha Tmath_0125 ENOG4108UN4 phage SPO1 DNA polymerase-related protein Tmath_0128 ENOG4108JUB Transcriptional regulator Tmath_0134 ENOG4105DUM transcriptional regulator, lysR family Tmath_0135 ENOG4105CUC YeeE YedE family protein Tmath_0137 ENOG41066VF YeeE YedE family protein Tmath_0139 ENOG4105DKQ ROK family Tmath_0140 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Tmath_0142 ENOG4105CXN decarboxylase Tmath_0143 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Tmath_0144 ENOG4105X0R protein from nitrogen regulatory protein P-II Tmath_0146 ENOG4105FA2 dna polymerase iii Tmath_0147 ENOG4105MA4 psp1 domain protein Tmath_0148 ENOG4105CEU Arginine dihydrolase Tmath_0149 ENOG41060K3 Methyltransferase Tmath_0150 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Tmath_0151 ENOG41076HS cation diffusion facilitator family transporter Tmath_0152 ENOG4105KRN Transcriptional regulator, abrb family Tmath_0153 ENOG4108JIC nucleoside recognition domain protein Tmath_0155 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Tmath_0156 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Tmath_0157 ENOG4105F8V Hydrolase, tatD family Tmath_0158 ENOG41069ER domain protein Tmath_0159 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Tmath_0163 ENOG4105WJF Tmath_0164 ENOG4108WZW RNA polymerase sigma Tmath_0165 ENOG4105D1F ATP-binding protein Tmath_0168 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Tmath_0169 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Tmath_0170 ENOG4105D6A Electron transport complex Tmath_0171 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit Tmath_0172 ENOG4105DZB Electron transport complex Tmath_0173 ENOG4105DGN Electron transport complex Tmath_0174 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit Tmath_0178 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Tmath_0179 ENOG41082DI 50s ribosomal protein l31 Tmath_0180 ENOG4107104 thymidine kinase Tmath_0181 ENOG4105CBJ Metal-dependent enzyme Tmath_0182 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Tmath_0183 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Tmath_0184 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) Tmath_0185 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Tmath_0186 ENOG4108YZG isomerase Tmath_0187 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Tmath_0189 ENOG4105ESV Glycosyl transferase, family 4 Tmath_0190 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Tmath_0193 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Tmath_0194 ENOG4105DCF alanine dehydrogenase Tmath_0198 ENOG4105MT0 Sporulation transcriptional regulator spoiiid Tmath_0199 ENOG4105DFF Rod shape-determining protein mreb Tmath_0200 ENOG4108JQA flagellar Tmath_0201 ENOG4105CGA flagellar basal-body rod protein FlgG Tmath_0203 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Tmath_0207 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Tmath_0210 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Tmath_0212 ENOG41090UW PTS System Tmath_0213 ENOG4105DT3 PTS system, galactitol-specific IIc component Tmath_0214 ENOG4105C5I Dehydrogenase Tmath_0217 ENOG4105CXK mandelate racemase muconate lactonizing Tmath_0219 ENOG4108UHU Aldolase Tmath_0221 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Tmath_0222 ENOG4105YHU PTS system Tmath_0224 ENOG4105F3R pts system mannose fructose sorbose family iid Tmath_0225 ENOG4108IQ3 PTS system Tmath_0227 ENOG4108UHU Aldolase Tmath_0228 ENOG4105C5I Dehydrogenase Tmath_0229 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Tmath_0230 ENOG4105CZN Potassium uptake protein Tmath_0231 ENOG4107ZYR domain protein Tmath_0234 ENOG4105CMG Carbohydrate kinase Tmath_0237 ENOG4105D2H Uronic isomerase Tmath_0238 ENOG4108UHU Aldolase Tmath_0239 ENOG4105DEI Mannitol dehydrogenase Tmath_0240 ENOG4105D7K pfkb domain protein Tmath_0241 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) Tmath_0243 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Tmath_0246 ENOG4105CNT hydrolase family 2 Tmath_0247 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) Tmath_0250 ENOG4105I82 acetyl xylan esterase Tmath_0256 ENOG4105DRS transport system, permease Tmath_0257 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Tmath_0260 ENOG4105ETE Transcriptional regulator (LacI family Tmath_0261 ENOG4108RVA ribokinase Tmath_0262 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) Tmath_0263 ENOG4105C2J ABC transporter Tmath_0264 ENOG4105CNN ABC, transporter Tmath_0265 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Tmath_0266 ENOG4106KNT transcriptional regulator Tmath_0267 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Tmath_0269 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component Tmath_0270 ENOG4105DRS transport system, permease Tmath_0274 ENOG4105EHZ conserved protein UCP016719 Tmath_0275 ENOG4105D17 glycoside hydrolase, family 3 domain protein Tmath_0276 ENOG4105RD7 BadF BadG BcrA BcrD Tmath_0277 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Tmath_0278 ENOG4108YM7 Gcn5-related n-acetyltransferase Tmath_0279 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) Tmath_0281 ENOG4105F32 YngK protein Tmath_0285 ENOG4108K9K Uncharacterised protein family (UPF0236) Tmath_0287 ENOG4105CE4 GlcNAc 6-P deacetylase Tmath_0288 ENOG4105CHM Aminotransferase Tmath_0289 ENOG4108ZB6 transcriptional regulator AsnC family Tmath_0291 ENOG4105CE1 Ferrous iron transport protein b Tmath_0292 ENOG4108K9K Uncharacterised protein family (UPF0236) Tmath_0294 ENOG4108JJB ABC transporter Tmath_0295 ENOG4108YZP cobalt ABC transporter, inner membrane subunit CbiQ Tmath_0296 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein Tmath_0297 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Tmath_0298 ENOG4105MRR Transcriptional regulator (By similarity) Tmath_0300 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Tmath_0301 ENOG4105UQX Mate efflux family protein Tmath_0302 ENOG410624X efflux transporter, rnd family, mfp subunit Tmath_0303 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tmath_0304 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tmath_0307 ENOG4105ERH Fumarylacetoacetate hydrolase Tmath_0308 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination Tmath_0309 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Tmath_0311 ENOG4105EYH Exonuclease Tmath_0312 ENOG4105D3R alkyl hydroperoxide reductase Tmath_0316 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) Tmath_0317 ENOG4107QPH glycogen) synthase Tmath_0318 ENOG4107ZTW SNARE associated Golgi Tmath_0320 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Tmath_0323 ENOG4105BZ8 glutamate synthase Tmath_0326 ENOG4108HRK Histidine kinase Tmath_0327 ENOG4108VB1 regulatoR Tmath_0328 ENOG4105DFW ABC transporter Tmath_0329 ENOG4105DFW ABC transporter Tmath_0331 ENOG4108HWW ABC transporter Tmath_0332 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Tmath_0333 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Tmath_0335 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Tmath_0336 ENOG4105DF9 Lipoate-protein, ligase Tmath_0337 ENOG4107QN2 dihydrolipoyl dehydrogenase Tmath_0340 ENOG4105CHM Aminotransferase Tmath_0342 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC Tmath_0345 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase Tmath_0350 ENOG4107QW4 alcohol dehydrogenase Tmath_0353 ENOG4105MKU Transcriptional regulator Tmath_0356 ENOG4105CIZ coA-substrate-specific enzyme activase Tmath_0358 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Tmath_0359 ENOG4105C4B ABC transporter, permease Tmath_0360 ENOG4105C8T Leucyl-tRNA synthetase Tmath_0361 ENOG4108UMN azlc family Tmath_0363 ENOG4105DD7 kinase (PfkB family Tmath_0364 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) Tmath_0365 ENOG41089WN small, acid-soluble spore protein tlp Tmath_0366 ENOG4105CJ3 phosphate transporter Tmath_0368 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Tmath_0370 ENOG410901P UPF0249 protein Tmath_0372 ENOG4105VCP PTS System Tmath_0373 ENOG4105F8D glycoside hydrolase family 4 Tmath_0374 ENOG4105CS2 ec 3.2.1.21 Tmath_0375 ENOG4105CTS PTS system mannitol-specific Tmath_0376 ENOG4105EMD TRANSCRIPTIONal Tmath_0379 ENOG4105CGH 5'-nucleotidase Tmath_0380 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Tmath_0381 ENOG4105EJ9 Membrane Tmath_0383 ENOG4105ETE Transcriptional regulator (LacI family Tmath_0385 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Tmath_0386 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tmath_0389 ENOG4105CNT hydrolase family 2 Tmath_0390 ENOG4105CS2 ec 3.2.1.21 Tmath_0392 ENOG4105FDK ABC transporter Tmath_0393 ENOG4105DSE periplasmic solute binding protein Tmath_0394 ENOG4105N80 Ferric uptake regulator, Fur family Tmath_0395 ENOG4108V0P LemA family Tmath_0396 ENOG4105DUM transcriptional regulator, lysR family Tmath_0397 ENOG4105D5B Sulfite reductase, subunit A Tmath_0398 ENOG4107SHJ sulfite reductase subunit b Tmath_0399 ENOG410810Y Sulfite reductase Tmath_0400 ENOG4105EYA deoxyribonuclease Tmath_0403 ENOG4107YH3 SUF system FeS assembly protein, NifU family Tmath_0409 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Tmath_0410 ENOG4105EHG Permease protein Tmath_0411 ENOG4105E0A ABC, transporter Tmath_0412 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Tmath_0417 ENOG4105CIH Imidazole acetol-phosphate transaminase Tmath_0418 ENOG4108YZT Adenosylcobinamide kinase Tmath_0421 ENOG41081F0 Precorrin-8x methylmutase Tmath_0423 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase Tmath_0424 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase Tmath_0425 ENOG4105DVK Precorrin-2 c20-methyltransferase Tmath_0426 ENOG4105CIA precorrin-4 C(11)-methyltransferase Tmath_0427 ENOG4108P62 biosynthesis protein (CbiG) Tmath_0428 ENOG4105E4R Precorrin-3B C17-methyltransferase Tmath_0429 ENOG4108JTQ reductase Tmath_0430 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Tmath_0433 ENOG4105D52 delta-aminolevulinic acid dehydratase Tmath_0434 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Tmath_0437 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Tmath_0438 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Tmath_0441 ENOG4108JJB ABC transporter Tmath_0454 ENOG4108IUW ABC transporter Tmath_0460 ENOG4105F22 Major Facilitator Superfamily Tmath_0470 ENOG4108ZXC Two component transcriptional regulator, luxr family Tmath_0477 ENOG4105CJ1 ABC, transporter Tmath_0484 ENOG4105CJ1 ABC, transporter Tmath_0487 ENOG4108DBC nitroreductase Tmath_0489 ENOG4108ZXC Two component transcriptional regulator, luxr family Tmath_0492 ENOG4105C19 ABC transporter Tmath_0495 ENOG4105CN9 Peptidase m42 family protein Tmath_0496 ENOG4105CN9 Peptidase m42 family protein Tmath_0497 ENOG4105CN9 Peptidase m42 family protein Tmath_0500 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tmath_0501 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Tmath_0502 ENOG4105CCS Glutamate formiminotransferase Tmath_0505 ENOG4105CG3 alpha amylase, catalytic region Tmath_0508 ENOG4107T3P ABC, transporter Tmath_0509 ENOG4105C2F Histidine kinase Tmath_0510 ENOG4105EQD regulatoR Tmath_0511 ENOG410908R Methenyltetrahydrofolate cyclohydrolase Tmath_0512 ENOG4107TFB basic membrane Tmath_0515 ENOG4108JQ9 ABC transporter Tmath_0516 ENOG4105UIB (ABC) transporter Tmath_0518 ENOG4105FDP GntR family transcriptional regulator Tmath_0520 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Tmath_0522 ENOG4105C8Q Methyl-accepting chemotaxis Tmath_0524 ENOG4105CI1 PTS System Tmath_0525 ENOG4105C5Y PTS System Tmath_0527 ENOG4107SDT Homocitrate synthase Tmath_0535 ENOG4105CBX hi0933 family Tmath_0536 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Tmath_0538 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Tmath_0540 ENOG41066UU tRNA (Adenine-N1-)-methyltransferase Tmath_0542 ENOG4105H67 Protein of unknown function (DUF421) Tmath_0543 ENOG410667J hydrolase Tmath_0544 ENOG4105ETE Transcriptional regulator (LacI family Tmath_0545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tmath_0546 ENOG4105BZU Histidine kinase Tmath_0551 ENOG4108RAC Rubrerythrin Tmath_0552 ENOG4106C07 ThiamineS Protein Tmath_0553 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Tmath_0555 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Tmath_0556 ENOG4105C7H Helicase, RecD TraA family Tmath_0557 ENOG4105MJ2 Competence protein Tmath_0561 ENOG4105E1Q flagellar hook-associated protein Tmath_0562 ENOG4105DTJ flagellar hook-associated protein Tmath_0564 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) Tmath_0569 ENOG4105CAQ asparagine synthetase Tmath_0572 ENOG4107RT6 flagellar hook-associated Tmath_0573 ENOG4105MQ3 flagellar protein FliS Tmath_0575 ENOG4105C8Q Methyl-accepting chemotaxis Tmath_0577 ENOG4108HW3 (ABC) transporter Tmath_0578 ENOG4105E5Q amino acid AbC transporter Tmath_0582 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tmath_0584 ENOG4108Z3G 3H domain protein Tmath_0586 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Tmath_0591 ENOG4108RSN SNARE associated Golgi Tmath_0592 ENOG4105CD3 dihydroorotase Tmath_0595 ENOG4105DBV ornithine carbamoyltransferase Tmath_0598 ENOG4105K8N protein family UPF0079, ATPase Tmath_0599 ENOG41072GX Peptidase M22 Glycoprotease Tmath_0601 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Tmath_0603 ENOG4105C5H ABC transporter Tmath_0604 ENOG4107R0U MotA TolQ exbB proton channel Tmath_0605 ENOG4106VK6 Flagellar motor protein Tmath_0608 ENOG4105DY9 regulatoR Tmath_0609 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Tmath_0613 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein Tmath_0614 ENOG4105BZ8 glutamate synthase Tmath_0617 ENOG4108UQV Membrane Tmath_0619 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Tmath_0624 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Tmath_0625 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Tmath_0626 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Tmath_0627 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Tmath_0628 ENOG4105C7N Xanthine uracil vitamin C permease Tmath_0629 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Tmath_0630 ENOG4105C8V SAICAR synthetase Tmath_0631 ENOG4105VR9 phosphoribosylformylglycinamidine synthase Tmath_0632 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Tmath_0633 ENOG4107QIK phosphoribosylformylglycinamidine synthase Tmath_0635 ENOG4105CXB phosphoribosylaminoimidazole synthetase Tmath_0636 ENOG4108V3E phosphoribosylglycinamide formyltransferase Tmath_0637 ENOG4105DC1 bifunctional purine biosynthesis protein purh Tmath_0638 ENOG4107QNG Phosphoribosylglycinamide synthetase Tmath_0640 ENOG4105CH2 amidohydrolase Tmath_0641 ENOG4105CKP Polysaccharide Biosynthesis Protein Tmath_0643 ENOG4105ETD TRANSCRIPTIONal Tmath_0645 ENOG4105VZJ PTS System Tmath_0646 ENOG4105CK1 PTS System Tmath_0647 ENOG4105VCP PTS System Tmath_0649 ENOG4105C4R Atp-dependent dna helicase Tmath_0650 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Tmath_0651 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Tmath_0653 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Tmath_0655 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Tmath_0656 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Tmath_0661 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Tmath_0662 ENOG4105VCP PTS System Tmath_0664 ENOG4105CK1 PTS System Tmath_0666 ENOG4105DJV ribulose-phosphate 3-epimerase Tmath_0667 ENOG4108YZG isomerase Tmath_0668 ENOG4105CS2 ec 3.2.1.21 Tmath_0671 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Tmath_0672 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase Tmath_0675 ENOG4108UTW Plays a role in the regulation of phosphate uptake Tmath_0676 ENOG4108IV0 ABC, transporter Tmath_0677 ENOG4105C0Z ABC transporter Tmath_0678 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Tmath_0679 ENOG4105C32 Amino acid ABC transporter (Permease) Tmath_0680 ENOG4105CP9 extracellular ligand-binding receptor Tmath_0685 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Tmath_0686 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tmath_0687 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Tmath_0688 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Tmath_0689 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Tmath_0691 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) Tmath_0692 ENOG41082I9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Tmath_0693 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Tmath_0694 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Tmath_0695 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Tmath_0696 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Tmath_0697 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Tmath_0698 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Tmath_0701 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component Tmath_0706 ENOG4105CJW magnesium transporter Tmath_0711 ENOG4105C8Q Methyl-accepting chemotaxis Tmath_0713 ENOG4105C5E polysaccharide biosynthesis protein Tmath_0714 ENOG4105C1B dTDP-glucose 4-6-dehydratase Tmath_0715 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Tmath_0716 ENOG4107TY6 Acylneuraminate cytidylyltransferase Tmath_0718 ENOG4105D2T synthase Tmath_0719 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG Tmath_0722 ENOG4107STW synthase Tmath_0723 ENOG4105D3Q Sugar transferase Tmath_0725 ENOG4105HTX biosynthesis protein Tmath_0731 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Tmath_0733 ENOG4108RE9 Phosphodiesterase Tmath_0735 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Tmath_0737 ENOG41071TK Uncharacterised protein family (UPF0150) Tmath_0754 ENOG4107SET aldo keto reductase Tmath_0759 ENOG4105VUF Transcriptional regulator Tmath_0761 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Tmath_0766 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Tmath_0767 ENOG4105HTX biosynthesis protein Tmath_0768 ENOG4108K88 Membrane Tmath_0771 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Tmath_0772 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tmath_0777 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Tmath_0779 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase Tmath_0780 ENOG4105C8M UPF0272 protein Tmath_0781 ENOG4105C8M UPF0272 protein Tmath_0782 ENOG4105BZU Histidine kinase Tmath_0783 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tmath_0787 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Tmath_0789 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Tmath_0794 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Tmath_0795 ENOG4107KJX Transcriptional regulator Tmath_0798 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Tmath_0799 ENOG4105DRS transport system, permease Tmath_0800 ENOG4107URF beta-phospho-glucomutase Tmath_0801 ENOG4105ETE Transcriptional regulator (LacI family Tmath_0803 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Tmath_0806 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Tmath_0808 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Tmath_0809 ENOG4105F0V Cell wall hydrolase Tmath_0814 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Tmath_0815 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Tmath_0816 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Tmath_0818 ENOG4105BZ1 (ABC) transporter Tmath_0819 ENOG4105BZ1 (ABC) transporter Tmath_0822 ENOG4105M3Z response regulator Tmath_0823 ENOG4105DYB Isoaspartyl dipeptidase Tmath_0824 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Tmath_0826 ENOG4105DR5 peptidase Tmath_0833 ENOG4105D07 Signal peptide peptidase, SppA Tmath_0837 ENOG4108UIC UPF0340 protein Tmath_0841 ENOG4108RDQ ABC transporter Tmath_0847 ENOG4105C85 amino acid Tmath_0848 ENOG4105EMN RNA polymerase sigma factor Tmath_0850 ENOG4105C2M dna polymerase I Tmath_0851 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Tmath_0854 ENOG4105E43 Extracellular solute-binding protein, family 5 Tmath_0856 ENOG4107SN7 NLP P60 protein Tmath_0857 ENOG4105CI3 gtp-binding protein typa Tmath_0858 ENOG4105E4C Lytic transglycosylase catalytic Tmath_0862 ENOG4108R3D Electron transport complex Tmath_0865 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit Tmath_0866 ENOG4105BZU Histidine kinase Tmath_0868 ENOG4107QIZ NADH dehydrogenase Tmath_0869 ENOG4107QHI -hydrogenase Tmath_0871 ENOG4108Z03 MAF-like protein Tmath_0872 ENOG4105W5Q DNA repair protein (RadC Tmath_0873 ENOG4105DFF Rod shape-determining protein mreb Tmath_0876 ENOG4105CJN penicillin-binding protein Tmath_0877 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Tmath_0878 ENOG4107QMS site-determining protein Tmath_0879 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) Tmath_0880 ENOG4105CNI cell division protein FtsW Tmath_0881 ENOG4108Z5K methylglyoxal synthase Tmath_0882 ENOG4105DR5 peptidase Tmath_0886 ENOG4105C03 ribonuclease Tmath_0887 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Tmath_0889 ENOG4108K9K Uncharacterised protein family (UPF0236) Tmath_0890 ENOG4108K9K Uncharacterised protein family (UPF0236) Tmath_0891 ENOG41067VP Protein of unknown function (DUF1049) Tmath_0892 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Tmath_0894 ENOG4105K46 50S ribosomal protein l27 Tmath_0896 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Tmath_0898 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Tmath_0899 ENOG4108WF2 Metal Dependent Phosphohydrolase Tmath_0901 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Tmath_0905 ENOG4105CAQ asparagine synthetase Tmath_0906 ENOG4105DZ1 carboxypeptidase Tmath_0907 ENOG4105KQC Competence protein Tmath_0909 ENOG4108W5N phosphatidylglycerophosphatase a Tmath_0913 ENOG41084EF Ferredoxin Tmath_0914 ENOG4105CM2 brancheD-chain amino acid aminotransferase Tmath_0917 ENOG4105PUK Membrane Tmath_0918 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Tmath_0919 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Tmath_0920 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 Tmath_0922 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Tmath_0923 ENOG4105EPD Oligopeptide transporter, Opt family Tmath_0927 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) Tmath_0932 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Tmath_0933 ENOG4105CSA Coproporphyrinogen iii oxidase Tmath_0935 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Tmath_0937 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Tmath_0939 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Tmath_0940 ENOG4105VUC UPF0237 protein Tmath_0943 ENOG4107S21 permease Tmath_0948 ENOG4105F3H Histidine kinase Tmath_0949 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Tmath_0952 ENOG4105CKK Glycosyl transferase, family 2 Tmath_0954 ENOG4105EDW glycosyl transferase, family 39 Tmath_0955 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Tmath_0956 ENOG4107YU2 histidine triad (hIT) protein Tmath_0957 ENOG4105VCC 30S ribosomal protein S21 Tmath_0959 ENOG41068P3 sporulation protein YqfC Tmath_0961 ENOG4105C9A Phoh family Tmath_0962 ENOG4105CTJ Metal Dependent Phosphohydrolase Tmath_0963 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Tmath_0965 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Tmath_0966 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Tmath_0969 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Tmath_0971 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Tmath_0972 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Tmath_0974 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Tmath_0990 ENOG4105BZ1 (ABC) transporter Tmath_0993 ENOG4108IUW ABC transporter Tmath_1002 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) Tmath_1004 ENOG4108Z0Z intracellular protease Pfpi family Tmath_1006 ENOG4107S9D Alpha beta hydrolase Tmath_1010 ENOG4108UVJ appr-1-p processing domain protein Tmath_1011 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Tmath_1013 ENOG41066FP Small acid-soluble spore protein I Tmath_1016 ENOG4105CNW domain protein Tmath_1017 ENOG4108UXE Protein tyrosine phosphatase Tmath_1020 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Tmath_1021 ENOG4107XCH Cyclase family Tmath_1024 ENOG4105EJQ L-serine dehydratase Tmath_1025 ENOG4105DPN Oligoendopeptidase f Tmath_1027 ENOG4105CQC Prephenate dehydratase Tmath_1028 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Tmath_1029 ENOG4105EVN Prephenate dehydrogenase Tmath_1030 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Tmath_1036 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Tmath_1037 ENOG4105EB3 Histidine kinase Tmath_1040 ENOG41066F8 ROK family Tmath_1041 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Tmath_1043 ENOG4107QIV Cytochrome c biogenesis protein Tmath_1044 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Tmath_1045 ENOG4105CXN decarboxylase Tmath_1050 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Tmath_1053 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Tmath_1057 ENOG4105C6T cysteine synthase Tmath_1058 ENOG4105CDY transcriptional regulatory protein Tmath_1059 ENOG4108V3W Chemotaxis protein, CheW Tmath_1061 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Tmath_1062 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Tmath_1063 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Tmath_1065 ENOG4105JFG SpoIID LytB domain protein Tmath_1067 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Tmath_1071 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Tmath_1072 ENOG4108Z0R Transferase Tmath_1073 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Tmath_1074 ENOG4108JIS Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Tmath_1076 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Tmath_1078 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Tmath_1079 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) Tmath_1080 ENOG4105C5X domain protein Tmath_1081 ENOG4107RBB ABC transporter, permease Tmath_1082 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tmath_1083 ENOG4105DJY efflux transporter, rnd family, mfp subunit Tmath_1086 ENOG4105CUT histidyl-tRNA synthetase Tmath_1087 ENOG4105C9M aspartyl-trna synthetase Tmath_1088 ENOG4105CUZ uba thif-type nad fad binding protein Tmath_1089 ENOG4105VPX protein, conserved in bacteria Tmath_1090 ENOG4105K63 Thioredoxin Tmath_1092 ENOG4106M28 alanine racemase domain protein Tmath_1095 ENOG4105C02 permease Tmath_1096 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Tmath_1097 ENOG4105VBH UPF0297 protein Tmath_1098 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Tmath_1099 ENOG41085AS UPF0473 protein Tmath_1100 ENOG4105I3K Ferric uptake regulator, Fur family Tmath_1101 ENOG4105CN5 Metallo-Beta-Lactamase Tmath_1102 ENOG41084CE UPF0342 protein Tmath_1104 ENOG4105HHA aminodeoxychorismate lyase Tmath_1105 ENOG4108VQJ O-methyltransferase Tmath_1106 ENOG4105CFP Peptidase U32 Tmath_1107 ENOG4107XRG penicillin-binding protein Tmath_1108 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tmath_1109 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Tmath_1110 ENOG4105E2X shikimate dehydrogenase Tmath_1111 ENOG4107QHF type ii secretion system protein e Tmath_1112 ENOG4105CZX twitching motility protein Tmath_1126 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Tmath_1127 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Tmath_1128 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Tmath_1129 ENOG4105DC7 peptidase M24 Tmath_1130 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Tmath_1132 ENOG4105CD2 stage iii sporulation protein aa Tmath_1134 ENOG4108CQH stage III sporulation protein AC Tmath_1135 ENOG4105KQ4 Stage iii sporulation protein ad Tmath_1137 ENOG410644B Stage III sporulation protein af Tmath_1140 ENOG4108ZSR alkaline shock protein Tmath_1141 ENOG4105M7K Involved in the transcription termination process (By similarity) Tmath_1142 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Tmath_1143 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Tmath_1144 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Tmath_1147 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Tmath_1148 ENOG4105DX0 Hemolysin A Tmath_1149 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Tmath_1150 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Tmath_1151 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Tmath_1152 ENOG4105S1Z Stage IV sporulation protein B Tmath_1153 ENOG4107QQR Sporulation Tmath_1162 ENOG4105MZ9 stage II sporulation protein m Tmath_1163 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tmath_1164 ENOG4105DZ1 carboxypeptidase Tmath_1166 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Tmath_1167 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tmath_1168 ENOG41084UG Pfam:DUF1458 Tmath_1169 ENOG41090VF Stage v sporulation protein ac Tmath_1173 ENOG4108Z4T Peptidase M50 Tmath_1174 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Tmath_1175 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Tmath_1176 ENOG4105PTM secreted protein Tmath_1178 ENOG4105KBJ sporulation protein ytfj Tmath_1179 ENOG4105DZ1 carboxypeptidase Tmath_1181 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Tmath_1182 ENOG4105FE9 pseudouridine synthase Tmath_1184 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Tmath_1185 ENOG4105CYW agmatinase Tmath_1186 ENOG4107QSA Oxaloacetate decarboxylase Tmath_1189 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Tmath_1191 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) Tmath_1192 ENOG4105D82 Glutamate dehydrogenase Tmath_1194 ENOG4105CVJ phosphoglycerate mutase Tmath_1195 ENOG4105CBX hi0933 family Tmath_1197 ENOG4105KHN chorismate mutase Tmath_1198 ENOG4105CAT Cytidine monophosphate kinase Tmath_1200 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Tmath_1201 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Tmath_1202 ENOG4105BZU Histidine kinase Tmath_1204 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Tmath_1206 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Tmath_1207 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Tmath_1208 ENOG4105II7 pyrroline-5-carboxylate reductase Tmath_1209 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Tmath_1210 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tmath_1211 ENOG4105CXI aluminum resistance protein Tmath_1212 ENOG4106F1P AAA ATPase, central domain protein Tmath_1213 ENOG4105C83 adenylosuccinate lyase Tmath_1215 ENOG4105DB7 PHP domain protein Tmath_1216 ENOG4105MCT stage V sporulation protein S Tmath_1217 ENOG4105D48 metallophosphoesterase Tmath_1218 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Tmath_1219 ENOG410902V Modulates RecA activity (By similarity) Tmath_1220 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Tmath_1221 ENOG4105CEV competence damage-inducible protein Tmath_1222 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Tmath_1223 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Tmath_1224 ENOG4105CNU cell division protein FtsK Tmath_1226 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit Tmath_1229 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Tmath_1230 ENOG4105C1V Peptidase, M16 Tmath_1232 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Tmath_1233 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Tmath_1234 ENOG4105DTN riboflavin biosynthesis protein ribF Tmath_1235 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Tmath_1236 ENOG4105SFS phosphoesterase RecJ domain protein Tmath_1237 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Tmath_1238 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Tmath_1240 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination Tmath_1241 ENOG4105CHV Transcription elongation factor NusA Tmath_1243 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Tmath_1245 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Tmath_1246 ENOG4105DZP Membrane-associated zinc metalloprotease Tmath_1247 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Tmath_1248 ENOG4105KNE Phosphatidate cytidylyltransferase Tmath_1249 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Tmath_1251 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Tmath_1252 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Tmath_1253 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Tmath_1257 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tmath_1258 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Tmath_1260 ENOG4108V3W Chemotaxis protein, CheW Tmath_1261 ENOG4105CBS Chea signal transduction histidine kinase Tmath_1262 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Tmath_1265 ENOG4105FZW flagellar biosynthesis regulator FlhF Tmath_1266 ENOG4105D7B Flagellar biosynthesis protein flha Tmath_1267 ENOG4105D00 flagellar biosynthetic protein flhB Tmath_1268 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Tmath_1269 ENOG4105VS8 Flagellar biosynthetic protein fliq Tmath_1270 ENOG4105CN7 Flagellar biosynthetic protein FliP Tmath_1272 ENOG4107YTP response regulator receiver protein Tmath_1273 ENOG4105DD5 Flagellar motor switch protein Tmath_1274 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Tmath_1275 ENOG4105X6C Flagellar basal body-associated protein FliL Tmath_1276 ENOG41068WV flagellar FlbD family protein Tmath_1277 ENOG4105BZE flagellar hook protein, FlgE Tmath_1279 ENOG410822I Flagellar hook capping protein Tmath_1285 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Tmath_1286 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Tmath_1287 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Tmath_1288 ENOG4108ZC9 flagellar basal-body rod protein flgc Tmath_1289 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Tmath_1292 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Tmath_1293 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Tmath_1294 ENOG4105C79 DNA protecting protein DprA Tmath_1295 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Tmath_1296 ENOG4105VFF UPF0102 protein Tmath_1297 ENOG4105C31 Tryptophanyl-tRNA synthetase Tmath_1298 ENOG4108JYZ YitT family Tmath_1299 ENOG4105C0P Mg chelatase subunit ChlI Tmath_1300 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) Tmath_1301 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Tmath_1302 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Tmath_1303 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Tmath_1304 ENOG4105VB6 UPF0109 protein Tmath_1305 ENOG4105K5M 30s ribosomal protein S16 Tmath_1307 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) Tmath_1308 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Tmath_1311 ENOG4105MCT stage V sporulation protein S Tmath_1313 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Tmath_1314 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) Tmath_1315 ENOG4107QW8 radical SAM domain protein Tmath_1318 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Tmath_1319 ENOG4105CBC glutamate synthase Tmath_1320 ENOG4105EYU Glutamine amido-transferase Tmath_1321 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Tmath_1323 ENOG4108YZA Nitrogen regulatory protein pii Tmath_1327 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Tmath_1328 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Tmath_1329 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Tmath_1330 ENOG4105CHR reductase Tmath_1331 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Tmath_1332 ENOG4105EA8 2-Nitropropane dioxygenase Tmath_1333 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Tmath_1334 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Tmath_1335 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) Tmath_1336 ENOG41067VY 50S ribosomal protein L32 Tmath_1337 ENOG4105KNH Nucleic acid-binding protein Tmath_1338 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Tmath_1339 ENOG4108IJ2 phosphate acetyltransferase Tmath_1341 ENOG4105H20 Sporulation integral membrane protein YlbJ Tmath_1343 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Tmath_1344 ENOG4106H78 methyltransferase Tmath_1347 ENOG4105EPR degv family Tmath_1349 ENOG4105DP4 dak2 domain fusion protein ylov Tmath_1350 ENOG4108ZSR alkaline shock protein Tmath_1354 ENOG4105DJV ribulose-phosphate 3-epimerase Tmath_1355 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Tmath_1356 ENOG4105D9P serine threonine protein kinase Tmath_1357 ENOG4108ZF3 Phosphatase Tmath_1358 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Tmath_1359 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Tmath_1362 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Tmath_1363 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Tmath_1364 ENOG4105C25 Primosomal protein n' Tmath_1365 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Tmath_1367 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Tmath_1369 ENOG4105DSJ YicC domain protein Tmath_1370 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Tmath_1371 ENOG4105C6X Major Facilitator Tmath_1373 ENOG4105F23 Fibronectin-binding protein Tmath_1375 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Tmath_1376 ENOG4108UMI ABC transporter, permease Tmath_1377 ENOG4105D01 (LipO)protein Tmath_1379 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Tmath_1382 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Tmath_1384 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) Tmath_1385 ENOG4105SKN orotidine 5''-phosphate decarboxylase Tmath_1386 ENOG4105CD3 dihydroorotase Tmath_1387 ENOG4105CXT aspartate transcarbamylase Tmath_1388 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Tmath_1390 ENOG4105C34 Pseudouridine synthase Tmath_1391 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Tmath_1392 ENOG4105KNA -acetyltransferase Tmath_1399 ENOG410813F Putative esterase Tmath_1402 ENOG4107QW4 alcohol dehydrogenase Tmath_1403 ENOG4107SET aldo keto reductase Tmath_1405 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Tmath_1407 ENOG4105EMN RNA polymerase sigma factor Tmath_1410 ENOG41067S9 phage shock protein C, PspC Tmath_1414 ENOG4105C28 cystathionine Tmath_1416 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Tmath_1420 ENOG4105DK0 Indole-3-glycerol phosphate synthase Tmath_1421 ENOG4108I0Q anthranilate phosphoribosyltransferase Tmath_1422 ENOG4105DDQ anthranilate synthase Tmath_1423 ENOG4105CRQ synthase (Component I) Tmath_1425 ENOG4105C28 cystathionine Tmath_1426 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) Tmath_1427 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Tmath_1428 ENOG4105CR5 Class II aldolase adducin family protein Tmath_1431 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Tmath_1432 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Tmath_1435 ENOG4105DBK s4 domain protein Tmath_1437 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Tmath_1438 ENOG4105DFA alanine racemase domain protein Tmath_1440 ENOG4105KME endoribonuclease L-psp Tmath_1441 ENOG4105BZW Glycerate kinase Tmath_1444 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) Tmath_1446 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Tmath_1447 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Tmath_1452 ENOG4105S2F Tmath_1455 ENOG4108UTW Plays a role in the regulation of phosphate uptake Tmath_1456 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Tmath_1458 ENOG4105C8U phosphate abc transporter Tmath_1459 ENOG4105CVA phosphate Tmath_1460 ENOG4105BZU Histidine kinase Tmath_1461 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Tmath_1463 ENOG4108BIK prc-barrel domain-containing protein Tmath_1464 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tmath_1465 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tmath_1466 ENOG4108AWX Sporulation factor SpoIIGA Tmath_1467 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Tmath_1468 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Tmath_1469 ENOG4105K67 small basic protein Tmath_1472 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Tmath_1473 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Tmath_1474 ENOG4105CNI cell division protein FtsW Tmath_1476 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Tmath_1477 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Tmath_1478 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Tmath_1479 ENOG4105CJN penicillin-binding protein Tmath_1486 ENOG4105C3G gtp-binding protein Tmath_1493 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Tmath_1494 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Tmath_1511 ENOG4107Y5K Resolvase Tmath_1514 ENOG4105DFM M18 family aminopeptidase Tmath_1515 ENOG4105WH1 Two component transcriptional regulator luxr family Tmath_1518 ENOG4105EWC Purine nucleoside phosphorylase Tmath_1519 ENOG4105C98 muts2 protein Tmath_1520 ENOG4105CFP Peptidase U32 Tmath_1522 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Tmath_1523 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Tmath_1524 ENOG4108RWN rrna methyltransferase Tmath_1527 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Tmath_1530 ENOG4105C22 threonyL-tRNA synthetase Tmath_1531 ENOG4108UH6 UPF0754 membrane protein Tmath_1534 ENOG4105XXY Thioredoxin Tmath_1535 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Tmath_1536 ENOG4105VEQ Cold shock protein Tmath_1537 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Tmath_1540 ENOG41083MR nifu domain-containing protein Tmath_1541 ENOG4108ZGC gaf domain protein Tmath_1543 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Tmath_1549 ENOG4107QSE Dipeptidase Tmath_1550 ENOG4105DG6 mannose-6-phosphate isomerase Tmath_1551 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Tmath_1552 ENOG4105EGD dinuclear metal center protein, YbgI family Tmath_1554 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tmath_1555 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Tmath_1556 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Tmath_1557 ENOG4105XZU Preprotein translocase, subunit SecG Tmath_1558 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Tmath_1559 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Tmath_1560 ENOG4105CP7 Triose-phosphate isomerase Tmath_1561 ENOG4105BZA Phosphoglycerate kinase Tmath_1564 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tmath_1565 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Tmath_1566 ENOG410667J hydrolase Tmath_1567 ENOG4105G5W regulator Fur family Tmath_1568 ENOG41073R8 VanW family Tmath_1569 ENOG4105CSM endonuclease III Tmath_1570 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Tmath_1572 ENOG410688J Ferredoxin Tmath_1575 ENOG4105C22 threonyL-tRNA synthetase Tmath_1577 ENOG4105EMS pseudouridine synthase Tmath_1581 ENOG4105D1H recombination factor protein RarA Tmath_1582 ENOG4108X8W Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Tmath_1586 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Tmath_1589 ENOG4105WEF catalase Tmath_1590 ENOG4108UIN ybak prolyl-trna synthetase associated region Tmath_1591 ENOG4105C3R Methionine synthase Tmath_1593 ENOG4107R76 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Tmath_1594 ENOG4107QYV phosphohexose isomerase Tmath_1595 ENOG4108RCM Nitroreductase Tmath_1598 ENOG4105CQS hydrogenase expression formation protein HypD Tmath_1602 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) Tmath_1604 ENOG4108HM5 NADH-ubiquinone oxidoreductase chain 49kDa Tmath_1606 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Tmath_1607 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Tmath_1608 ENOG4105D65 subunit l Tmath_1610 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Tmath_1612 ENOG4105E90 ABC transporter Tmath_1613 ENOG4108IJ8 ABC transporter Tmath_1615 ENOG4105UQX Mate efflux family protein Tmath_1617 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Tmath_1619 ENOG4105CA9 Pyruvate kinase Tmath_1620 ENOG4105CTQ phosphohexokinase Tmath_1622 ENOG4105C0B DNA polymerase III (alpha subunit) Tmath_1624 ENOG4105KRI phosphocarrier protein (HPr Tmath_1625 ENOG4105CIE May be required for sporulation (By similarity) Tmath_1627 ENOG4108IUK alpha amylase, catalytic Tmath_1631 ENOG4105EG2 ABC transporter, permease Tmath_1632 ENOG4105D56 permease protein Tmath_1633 ENOG4107FKK extracellular solute-binding protein family 1 Tmath_1638 ENOG4105D4A Cell wall formation (By similarity) Tmath_1643 ENOG4105C59 p-type ATPase Tmath_1644 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Tmath_1647 ENOG410681U heavy metal transport detoxification protein Tmath_1648 ENOG4105DQR SNARE associated Golgi Tmath_1649 ENOG4105VYW UPF0251 protein Tmath_1652 ENOG4108T0W nitrous oxide maturation protein NosY Tmath_1656 ENOG4108HWH (ABC) transporter Tmath_1657 ENOG4108U1V ABC transporter, permease Tmath_1658 ENOG4108HUF Transporter Tmath_1659 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase Tmath_1660 ENOG4107QW8 radical SAM domain protein Tmath_1661 ENOG4107YM4 Beta-lactamase domain-containing protein Tmath_1663 ENOG4105D1F ATP-binding protein Tmath_1664 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Tmath_1670 ENOG4108JVH Protein of unknown function DUF43 Tmath_1671 ENOG4105ETE Transcriptional regulator (LacI family Tmath_1672 ENOG4105D7K pfkb domain protein Tmath_1673 ENOG4107R3K hydrolase Tmath_1676 ENOG4107FKK extracellular solute-binding protein family 1 Tmath_1680 ENOG4105CJN penicillin-binding protein Tmath_1683 ENOG4108MDK Dehydrogenase Tmath_1684 ENOG4105CMD Transcriptional regulator, GntR family Tmath_1685 ENOG4105CR5 Class II aldolase adducin family protein Tmath_1686 ENOG4105EF1 ribulokinase Tmath_1687 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) Tmath_1691 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) Tmath_1692 ENOG4105DRS transport system, permease Tmath_1694 ENOG4108JE9 extracellular solute-binding protein family 1 Tmath_1695 ENOG4106Z5D Glycoside Hydrolase Family 43 Tmath_1696 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Tmath_1699 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Tmath_1700 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Tmath_1701 ENOG4107T3P ABC, transporter Tmath_1702 ENOG4105C8I hydrolase, family 38 Tmath_1703 ENOG4105ID8 Transcriptional regulator, ARAC family Tmath_1704 ENOG4105CNT hydrolase family 2 Tmath_1710 ENOG4105E2R ROK family Tmath_1711 ENOG4105CMR udp-glucose 4-epimerase Tmath_1712 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Tmath_1713 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase Tmath_1716 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Tmath_1717 ENOG41069H7 transport system small permease component Tmath_1718 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Tmath_1721 ENOG4105D2H Uronic isomerase Tmath_1722 ENOG4105DEI Mannitol dehydrogenase Tmath_1723 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Tmath_1725 ENOG4105C5I Dehydrogenase Tmath_1728 ENOG4105C5I Dehydrogenase Tmath_1731 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Tmath_1739 ENOG4105NBF ammecr1 domain protein Tmath_1741 ENOG4105CEY Amp-dependent synthetase and ligase Tmath_1744 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Tmath_1748 ENOG4105CJN penicillin-binding protein Tmath_1751 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Tmath_1752 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Tmath_1753 ENOG4108N5B 2-phosphosulfolactate phosphatase Tmath_1754 ENOG4105C0H protease Tmath_1756 ENOG4105DR5 peptidase Tmath_1757 ENOG4105CRP Part of the ABC transporter FtsEX involved in Tmath_1758 ENOG4105CAK Cell division ATP-binding protein ftsE Tmath_1759 ENOG4107VHA regulatoR Tmath_1764 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Tmath_1765 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Tmath_1769 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Tmath_1774 ENOG4105VDH Dihydroxyacetone kinase Tmath_1776 ENOG4105CMT Dihydroxyacetone kinase Tmath_1777 ENOG4108JUB Transcriptional regulator Tmath_1782 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Tmath_1783 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator Tmath_1789 ENOG4108IGT Dipeptidase Tmath_1791 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Tmath_1792 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Tmath_1795 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Tmath_1796 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Tmath_1797 ENOG4105CIH Imidazole acetol-phosphate transaminase Tmath_1798 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Tmath_1799 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Tmath_1800 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) Tmath_1806 ENOG4105CJ1 ABC, transporter Tmath_1807 ENOG4105E2V Glycosyltransferase 36 Tmath_1808 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Tmath_1809 ENOG4105CK5 oxidoreductase Tmath_1810 ENOG4105DWV Homoserine O-trans-acetylase Tmath_1812 ENOG4105D6E homoserine dehydrogenase Tmath_1814 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Tmath_1815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Tmath_1816 ENOG4105F8J Adenylate Guanylate cyclase Tmath_1822 ENOG4108IUS Transketolase Tmath_1823 ENOG4108HHA Transketolase Tmath_1824 ENOG4108JYZ YitT family Tmath_1829 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) Tmath_1831 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Tmath_1833 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Tmath_1834 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Tmath_1842 ENOG4105FDF Could be involved in DNA repair (By similarity) Tmath_1843 ENOG4108J9Q DNA ligase Tmath_1844 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme Tmath_1861 ENOG4105DZR Type I site-specific deoxyribonuclease Tmath_1863 ENOG4105EKX Restriction modification system DNA (Specificity Tmath_1864 ENOG4105CVR type I restriction-modification system Tmath_1867 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Tmath_1869 ENOG4105E9Q Acyl-transferase Tmath_1871 ENOG4107RE7 phosphate butyryltransferase Tmath_1878 ENOG4105CKM Branched-chain carboxylic acid kinase Tmath_1879 ENOG4107RDP Dehydrogenase Tmath_1880 ENOG4107RE7 phosphate butyryltransferase Tmath_1881 ENOG4105CKM Branched-chain carboxylic acid kinase Tmath_1883 ENOG4105C8B TIGR00159 family Tmath_1887 ENOG4107XGZ Hydrolase Tmath_1894 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) Tmath_1896 ENOG4105D22 carbon starvation protein Tmath_1898 ENOG4108UJD 30S ribosomal protein S9 Tmath_1899 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Tmath_1900 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Tmath_1901 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Tmath_1902 ENOG4108JJB ABC transporter Tmath_1903 ENOG4108JJB ABC transporter Tmath_1904 ENOG4108ZT0 50S ribosomal protein l17 Tmath_1905 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tmath_1906 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Tmath_1907 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Tmath_1908 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Tmath_1909 ENOG41067V7 50S ribosomal protein L36 Tmath_1910 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Tmath_1913 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Tmath_1914 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Tmath_1915 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Tmath_1916 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Tmath_1917 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Tmath_1919 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Tmath_1920 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Tmath_1921 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Tmath_1922 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Tmath_1923 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Tmath_1924 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Tmath_1925 ENOG41082SA 50s ribosomal protein l29 Tmath_1926 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Tmath_1927 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Tmath_1928 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Tmath_1929 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Tmath_1930 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Tmath_1931 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Tmath_1932 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Tmath_1933 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Tmath_1934 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Tmath_1935 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Tmath_1936 ENOG4105QIV RNA polymerase Tmath_1937 ENOG4105M0M Tetracycline resistance protein Tmath_1938 ENOG4105C2N RNA methyltransferase TrmH family group 3 Tmath_1940 ENOG4105C8N cysteinyl-tRNA synthetase Tmath_1941 ENOG4105D7W serine acetyltransferase Tmath_1945 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Tmath_1947 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Tmath_1948 ENOG4105CTP PilT protein domain protein Tmath_1950 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Tmath_1951 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Tmath_1953 ENOG4105EG2 ABC transporter, permease Tmath_1955 ENOG4107FKK extracellular solute-binding protein family 1 Tmath_1958 ENOG41066A3 ATP guanido phosphotransferase Tmath_1959 ENOG4108Z0C Uvrb UvrC protein Tmath_1962 ENOG4105C6K Malic enzyme Tmath_1963 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Tmath_1964 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Tmath_1965 ENOG4105BZU Histidine kinase Tmath_1969 ENOG410867B UPF0291 protein Tmath_1971 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein Tmath_1975 ENOG4105CJ1 ABC, transporter Tmath_1992 ENOG4105PW4 Sugar fermentation stimulation protein homolog Tmath_1993 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase Tmath_1994 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Tmath_1995 ENOG4105EEI dihydropteroate synthase Tmath_1996 ENOG4105EUJ GTP cyclohydrolase i Tmath_1997 ENOG4105CRK lysyL-tRNA synthetase Tmath_1998 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Tmath_2004 ENOG4105E1K spore germination protein Tmath_2005 ENOG4105GEU Spore germination protein Tmath_2006 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Tmath_2007 ENOG4105FH5 Membrane Tmath_2008 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein Tmath_2010 ENOG4107QX3 carboxylase Tmath_2012 ENOG4105CKU formyltetrahydrofolate synthetase Tmath_2013 ENOG4105BZU Histidine kinase Tmath_2015 ENOG4108UGV hypoxanthine phosphoribosyltransferase Tmath_2016 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Tmath_2018 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tmath_2019 ENOG4105SX7 Transporter Tmath_2026 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase Tmath_2027 ENOG4105BZU Histidine kinase Tmath_2031 ENOG41082MP copper ion binding protein Tmath_2032 ENOG4105C59 p-type ATPase Tmath_2036 ENOG4105C6T cysteine synthase Tmath_2049 ENOG4105D49 3-dehydroquinate synthase Tmath_2050 ENOG41060GV RNA binding s1 domain protein Tmath_2056 ENOG4105VYY sporulation protein yabp Tmath_2057 ENOG4105JFG SpoIID LytB domain protein Tmath_2058 ENOG41082I2 s4 domain protein Tmath_2059 ENOG4105K70 DNA-binding protein Tmath_2060 ENOG4108IY2 MazG family Tmath_2062 ENOG4107SFI Major Facilitator superfamily Tmath_2063 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Tmath_2064 ENOG4108IJ0 Aspartate ammonia-lyase Tmath_2065 ENOG4105MAX Superoxide reductase Tmath_2069 ENOG4105EAH synthase Tmath_2072 ENOG4105CEP NADH dehydrogenase Tmath_2076 ENOG4108K4H Tmath_2079 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Tmath_2083 ENOG4105CH7 arginosuccinase Tmath_2084 ENOG4105CDH Citrulline--aspartate ligase Tmath_2086 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Tmath_2087 ENOG4105C8Y Acetylornithine aminotransferase Tmath_2089 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Tmath_2095 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein Tmath_2096 ENOG4105BZ8 glutamate synthase Tmath_2097 ENOG4105DCG PHP domain protein Tmath_2103 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Tmath_2104 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Tmath_2105 ENOG4105N67 Proton-coupled thiamine transporter YuaJ Tmath_2106 ENOG4105BZ1 (ABC) transporter Tmath_2108 ENOG41067TZ transcriptional regulator, MarR family Tmath_2109 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Tmath_2110 ENOG4108EKI Dehydrogenase Tmath_2112 ENOG4105CPC Aldo Keto reductase Tmath_2113 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) Tmath_2114 ENOG4105DEF Extracellular solute-binding protein, family 5 Tmath_2117 ENOG4105C3U ABC transporter Tmath_2118 ENOG4108JQ7 (ABC) transporter Tmath_2119 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein Tmath_2120 ENOG4105C75 arginyL-tRNA synthetase Tmath_2122 ENOG4105CPF Cell wall formation (By similarity) Tmath_2123 ENOG4105XEW small acid-soluble spore protein Tmath_2124 ENOG4105MSI germination protein ypeb Tmath_2126 ENOG4108ZXQ stage ii sporulation protein r Tmath_2128 ENOG4108Q8B Spore germination protein Tmath_2132 ENOG4105DRR Transcriptional regulator, GntR family Tmath_2135 ENOG4105W42 Veg protein Tmath_2136 ENOG4105XFA sporulation peptidase YabG Tmath_2137 ENOG4108M14 stage v sporulation protein t Tmath_2138 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Tmath_2139 ENOG4108JA2 transcriptioN-repair coupling factor Tmath_2142 ENOG4105C0H protease Tmath_2143 ENOG4105BZU Histidine kinase Tmath_2144 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tmath_2145 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Tmath_2146 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Tmath_2148 ENOG4105DFT pur operon repressor Tmath_2149 ENOG4105DFU Cell wall formation (By similarity) Tmath_2153 ENOG4105ETE Transcriptional regulator (LacI family Tmath_2155 ENOG4105VN1 Heat shock protein Tmath_2158 ENOG4105DM4 PTS System Tmath_2159 ENOG4105DM4 PTS System Tmath_2160 ENOG4105DE4 1-phosphofructokinase Tmath_2161 ENOG4105E98 transcriptional regulator DeoR family Tmath_2164 ENOG4107GBW cellulosome anchoring protein cohesin Tmath_2168 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Tmath_2170 ENOG4105CY0 Metallo-Beta-Lactamase Tmath_2174 ENOG4105C5R Aminotransferase Tmath_2177 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Tmath_2178 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Tmath_2180 ENOG41090I5 UPF0735 ACT domain-containing protein Tmath_2181 ENOG4105CUB amino acid Tmath_2182 ENOG4105Q2H domain protein Tmath_2183 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) Tmath_2184 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Tmath_2203 ENOG4107YH3 SUF system FeS assembly protein, NifU family Tmath_2206 ENOG4105DIW FeS assembly protein SUFB Tmath_2207 ENOG4105C3K feS assembly ATPase SufC Tmath_2208 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Tmath_2212 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Tmath_2214 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Tmath_2217 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Tmath_2221 ENOG4105BZU Histidine kinase Tmath_2224 ENOG4105DR5 peptidase Tmath_2226 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Tmath_2227 ENOG4105CD8 aminopeptidase N Tmath_2229 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 Tmath_2231 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Tmath_2232 ENOG4105DZ0 fad dependent oxidoreductase Tmath_2233 ENOG4105C8Q Methyl-accepting chemotaxis Tmath_2235 ENOG4105DPN Oligoendopeptidase f Tmath_2237 ENOG4105C8J )-transporter Tmath_2241 ENOG4105M56 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Tmath_2243 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) Tmath_2244 ENOG4105KXQ Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Tmath_2246 ENOG4105QD4 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Tmath_2250 ENOG4105C2W permease Tmath_2258 ENOG4105IJJ transcriptional regulator, crp fnr family Tmath_2259 ENOG4105CDU Replicative dna helicase Tmath_2260 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Tmath_2261 ENOG4105BZR domain protein Tmath_2264 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Tmath_2265 ENOG4108UUM single-stranded DNA-binding protein Tmath_2266 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Tmath_2267 ENOG4105VDK protein, conserved in bacteria Tmath_2268 ENOG4105D8X mechanosensitive ion channel Tmath_2269 ENOG4108ZDA Sporulation protein YyaC Tmath_2271 ENOG4105DDG Cyanophycinase Tmath_2274 ENOG4105C9B Cysteine desulfurase Tmath_2275 ENOG4105FA0 parb-like partition protein Tmath_2276 ENOG4107QJE Chromosome Partitioning Protein Tmath_2277 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) Tmath_2281 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Tmath_2282 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Tmath_2283 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein Tmath_2284 ENOG4107R4E Membrane Tmath_2285 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Tmath_2286 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Tmath_2287 ENOG4105VG0 50S ribosomal protein l34